KR102308165B1 - Shampoo composition for preventing hair loss - Google Patents

Abstract

The present invention relates to a shampoo composition for preventing hair loss and, more specifically, to a shampoo composition comprising extracts of Cercidiphyllum japonicum bark and Sonchus brachyotus DC. as active ingredients. The shampoo composition according to the present invention has an advantage in that the shampoo composition is highly effective in preventing hair loss and promoting hair growth, as well as alleviating itching and dandruff, and improving the condition of the scalp and hair.

Description

Shampoo composition for preventing hair loss

The present invention relates to a shampoo composition for preventing hair loss, and more particularly, to a shampoo composition for preventing hair loss that prevents hair loss and promotes hair by including extracts of cassia bark and sardine grass.

On average, the number of human hair is about 100,000 to 120,000. Hair has a life cycle of development, growth, degeneration, and telogen, and it is normal for about 50 to 100 hairs to fall out per day that enter the telogen phase. Hair falls out after a certain period of time and new hair grows. Unlike fingernails and toenails, it has a 'grow-rest-fall' cycle. In the case of animals that molt, since the hair cycle of the entire hair is the same, the hair falls out at the same time and new growth occurs, so-called molting. However, since each human hair has its own hair cycle, it always maintains a constant number of hairs without molting.

In the case of human hair, it falls out after 3 years of growth, and new hair grows back in the same place 3 months later. There are about 80,000 hairs, and 70 of them fall out a day, and about 70 hairs that fell out 3 months ago are newly grown, so 80,000 hairs are always maintained.

However, modern people living in a busy life like today are prone to various kinds of stress. These stresses and the effects of aging work most closely on hair loss. In the past, it was recognized that hair loss was caused by heredity, but recently, hair loss is a phenomenon of aging, and the fact that the period is advanced according to changes in the living environment is a big problem.

It is known that alopecia is basically caused by the lack of energy in the hair roots because the function of making energy, that is, the hair energy cycle, does not work normally.

Testosterone, a type of male hormone (androgen) known to interfere with the generation of energy necessary for hair growth and development, is DHT (Dihydrotestosterone) whose activity is increased by the action of 5 alpha-reductase distributed around the hair follicle. ) is changed to Activated DHT binds to androgen receptors, thereby shortening the hair growth phase.

By shrinking the size of the hair follicles, it gradually thins the hair and eventually causes hair loss.

As hair loss progresses, the nipples present at the root of the hair become smaller, the thickness of the hair becomes thinner, and the hair cycle becomes shorter at the same time. In other words, if the hairs that should fall out after 3 years of growth fall out after 1 year of growth, about 210 hairs are lost per day. If hair loss continues, the hair changes to downy hair, and the hair cycle becomes shorter and falls out after a little growth, so the hair becomes thin and not long.

Therefore, under the assumption that if a factor that can control male hormones is applied, hair loss will be prevented. Propecia, a male hormone inhibitor recognized as a hair loss treatment by the FDA in 1997, Doota, an enlarged prostate and effective for preventing hair loss, and Minoxidil, an external application and antihypertensive agent (British Journal of Dermatology. 2004: 150: 186~194) are the most representative Hair loss prevention and hair growth agents.

However, when such a hair loss prevention agent or hair growth agent is applied, various side effects are often observed due to imbalance in body homeostasis.

In addition, since hair loss occurs due to a complex system, there is a problem that narrow treatment such as hormone suppression is only a short-sighted prescription.

Accordingly, compositions for preventing hair loss and hair growth using various natural substances have been proposed. As an example, Korean Patent Publication No. 10-0839704 discloses a composition for preventing hair loss and promoting hair growth containing Gujeolcho, a kind of wild chrysanthemum. In addition, Korean Patent Publication No. 10-0581316 discloses a composition for preventing hair loss and promoting hair growth containing a mixed extract of various herbal medicines of Chungeulja, Gamsonghyang, Gamguk, Doin, Cornflower, Tosaja, Omija, Baekchul, pine needles and Angelica. In Korean Patent Publication No. 10-0609210, the inhibitory effect of 5-α reductase on the β-sitosterol component of Angelica root and blood flow by the inulin component of Angelica root by containing an ethanol extract of Angelica root and burdock root. A method for producing an anti-hair loss shampoo having an anti-hair loss effect as an improvement effect is disclosed, and Republic of Korea Patent Publication No. 10-0579710 contains Ginkgo Ride A, Ginkgo Ride B, and Virobalide extracted from ginkgo leaves to provide anti-dandruff and anti-dandruff effects. A shampoo composition having both a hair loss prevention effect is disclosed, and in Korean Patent Publication No. 10-0806125, various natural oriental medicinal materials are put in gold and silver water in which gold and silver are dissolved, and an extract extracted by boiling is mixed with the shampoo composition to prevent hair loss. And a method for producing a shampoo having a wool effect is disclosed. In addition, Korean Patent Registration No. 10-1888957 discloses a shampoo composition comprising a white dandelion extract.

However, there was no case in the prior literature where extracts of cassia bark and sardinia were used to prevent hair loss and maximize the wool effect of the hair.

KR 10-0839704 B1 KR 10-0581316 B1 KR 10-0609210 B1 KR 10-0806125 B1 KR 10-1888957 B1

An object of the present invention is to provide a shampoo composition for preventing hair loss and promoting hair loss by providing a shampoo composition comprising an extract of cassia bark and sardine grass.

Another object of the present invention is to provide a shampoo composition for preventing hair loss which has excellent effects of improving dandruff, itchiness, and improving hair condition by further comprising a paracres extract.

The shampoo composition for preventing hair loss of the present invention for achieving the above object is characterized in that it comprises a cassia bark extract and a sardepool extract as active ingredients.

The cassia bark extract and sardinia extract are characterized in that it has a hair papilla cell growth promoting activity.

It is characterized in that it further comprises an extract of Paracres as an active ingredient.

The cassia bark extract, the extract of sardinia, and the paracreas extract are, with respect to 100% by weight of the shampoo composition, 0.1 to 5% by weight of the cassia bark extract, 0.1 to 5% by weight of the sardine extract, and 0.1 to 5% by weight of the paracreas extract %, and the cassia bark extract, the extract of sadepus and the Paracres extract are extracted using water, alcohol or an aqueous alcohol solution, and the alcohol is one of methanol, ethanol, propanol, isopropanol or butanol. characterized by that.

According to the shampoo composition for preventing hair loss of the present invention, there is an advantage in that it has an excellent effect of preventing hair loss and promoting hair, as well as improving dandruff, itching, and improving the condition of the scalp and hair.

1 is a graph showing the results of Test Example 1 according to the present invention.

Hereinafter, the present invention will be described in detail.

The present invention is characterized in that it contains a cassia bark extract and a sardine extract as active ingredients, wherein the cassia bark extract and sardine extract restore hair damaged by other causes such as stress, and inhibit hair loss and has the effect of promoting hair growth.

The cassia tree is a deciduous broad-leaved arboreous tree of the dicotyledonous plant Buttercylaceae, the scientific name of which is Cercidiphyllum Japonicum S et Z.

The cassia bark extract has the advantage of preventing hair loss through interaction with the sardine extract, promoting hair growth, and improving the condition of the hair.

The sardine grass is a perennial herb belonging to the genus Compositae and Sonchus distributed mainly in wet areas and brackish areas of reclaimed land, such as Korea, Japan, China, and Russia.

Sanga sade grass extract prevents hair loss and promotes hair growth through interaction with cassia bark extract. In the present invention, the sardine grass, as well as outpost, flowers, stems, leaves, and one or more of the roots may be used.

The extract according to the present invention may be obtained by extraction and separation from nature using extraction and separation methods known in the art, and 'extract' as defined in the present invention is cassia bark or It is extracted from sardinia, and includes, for example, all of the cassia bark or crude extract of sardinia, polar solvent-soluble extract, or non-polar solvent-soluble extract.

As a suitable solvent for extracting the extract from the cassia bark or sade grass, any pharmaceutically acceptable organic solvent may be used, and water or an organic solvent may be used, but is not limited thereto, for example, , water, alcohol, or an aqueous alcohol solution, and the alcohol is preferably one of methanol, ethanol, propanol, isopropanol and butanol.

And as the extraction method, any one of methods such as hot water extraction, cold extraction, reflux cooling extraction, solvent extraction, steam distillation, ultrasonic extraction, elution, and compression can be selected and used. In addition, the desired extract may be further subjected to a conventional fractionation process, and may be purified using a conventional purification method. There is no limitation on the method for preparing the cassia bark extract or the sardae grass extract of the present invention, and any known method may be used.

For example, the cassia bark or sade grass contained in the composition of the present invention is a powdered state by an additional process such as distillation under reduced pressure and freeze-drying or spray-drying the primary extract extracted by the hot water extraction or solvent extraction method described above. can be manufactured. In addition, fractions further purified by using various chromatography methods such as silica gel column chromatography, thin layer chromatography, and high performance liquid chromatography for the primary extract can also get

Therefore, in the present invention, the extract of Cassia bark or Sardinia is a concept including all extracts, fractions and purified products obtained in each step of extraction, fractionation or purification, and dilutions, concentrates or dried products thereof.

In addition, in the present invention, cassia bark or sardine grass may be extracted by putting all at once or may be used by mixing after each extraction, but in order to suppress the extraction of subcomponents as much as possible during efficient extraction of active ingredients and mixed extraction of each material. It is preferable to use a mixture after individual extraction.

In addition, in the present invention, the cassia bark extract and sardine extract extract, based on 100% by weight of the shampoo composition, may be included in the range of 0.1 to 5% by weight, respectively, and when the content is too small, hair loss prevention and hair growth promotion This is because the effect is insignificant, and even if it is in excess, it cannot have an enhanced effect any more.

As described above, the shampoo composition of the present invention comprising the cassia bark extract and the sardine extract extract has the advantage of having an excellent effect of preventing hair loss and promoting hair growth by having a hair papilla cell growth promoting activity while improving the condition of the hair. .

On the other hand, it is preferable that the shampoo composition of the present invention further comprises Paracres extract as an active ingredient in order to improve dandruff and itchiness. That is, the cassia bark extract and sardinia extract are excellent in preventing hair loss and promoting hair growth, but the effect of improving dandruff and itchiness is insignificant, and this is to be improved through the Paracres extract. In addition, the Paracres extract further enhances the effect of preventing hair loss and promoting hair growth.

The Paracress (Paracress, Acmella oleracea) is an annual plant or perennial plant of the Asteraceae family, and is native to tropical Brazil in East India and South America. The corolla and leaves are used mainly as spices because they give off a unique flavor. In the present invention, Paracress may use one or more of corollas, leaves, stems and roots, as well as outposts.

In the present invention, the method for preparing the extract of Paracres is the same as the above-described cassia bark extract and sardine extract, and detailed description thereof will be omitted. That is, the Paracres extract also uses various known methods in the field to which this technology belongs, and water, alcohol or an aqueous alcohol solution is used as an extraction solvent, but the alcohol is one of methanol, ethanol, propanol, isopropanol or butanol. It is best to use that.

In addition, the Paracres extract is preferably contained in an amount of 0.1 to 5% by weight based on 100% by weight of the shampoo composition, and when the content is less than 0.1% by weight, the effect of improving dandruff and itchiness, preventing hair loss and promoting hair growth is insignificant, This is because even if it exceeds 5% by weight, it does not have any further enhanced action effect.

On the other hand, it is natural that the shampoo composition of the present invention may further include a commonly used natural surfactant and functional additives as active ingredients.

Here, the natural surfactant may be one or more of cocamide diethanol amine, disodium laureth sulfosuccinate, cocobetaine, and olive surfactant, and the functional additive is polyquater, a thickener, and olive liquid, a solubilizer. , silk amino acids and peptides as nutrients, glycerin and betaine as moisturizing agents, as well as panthenol and provitamin E.

In addition, various additives in addition to the above-described components may be further included, and the implementation is not limited.

Hereinafter, the shampoo composition of the present invention will be described in more detail through specific examples.

(Example 1): Preparation of cassia bark extract and sardinia extract

After grinding the cassia bark, 2 kg of this powder was put in 4 L of 70% ethanol aqueous solution, and after repeated reflux cooling extraction at 70 ° C. for 3 hours 3 times, foreign substances were removed with an ultrafilter. Then, it was concentrated under reduced pressure as much as possible at 38°C using a rotary evaporator, and then dried again using a freeze dryer.

In addition, after drying and grinding the sardine grass, 2 kg of this powder was put in 4 L of a 70% aqueous ethanol solution, and after repeated reflux cooling extraction at 70 ° C. for 3 hours 3 times, foreign substances were removed with an ultrafilter. Then, it was concentrated under reduced pressure as much as possible at 38°C using a rotary evaporator, and then dried again using a freeze dryer.

And the extracted cassia bark extract and sardine grass extract were mixed in a 1:1 weight ratio.

(Example 2): Preparation of cassia bark extract, sardinia extract and paracreth extract

After drying and grinding the leaves of Paracress, 2 kg of this powder was put in 4 L of 70% ethanol aqueous solution, and extracted by reflux cooling at 70° C. for 3 hours 3 times, and then foreign substances were removed with an ultrafilter. Then, it was concentrated under reduced pressure as much as possible at 38°C using a rotary evaporator, and then dried again using a freeze dryer.

And the Paracres extract was mixed with the cassia bark extract and the sardipul extract prepared as in Example 1 in a weight ratio of 1:1:1.

(Comparative Example 1)

In the same manner as in Example 1, a cassia bark extract was prepared.

(Comparative Example 2)

In the same manner as in Example 1, a sadeful extract was prepared.

(Test Example 1): Evaluation of the effect on growth of human hair dermal papilla cells

The effect of the sample on the cell growth effect of human hair papilla cells was evaluated using human hair dermal papilla cells (HHDPC).

HHDPC was inoculated into a 96-well plate at ^{0.25 × 10 4} cells/ml in MSC (Mesenchymal Stem Cell) medium containing 10% FBS (fetal bovine serum, Cambrex). For 24 hours, 37°C, 5 % CO ₂ Incubated under humid conditions.

The samples of Examples 1 and 2 and Comparative Examples 1 and 2 were treated in the culture medium at a concentration of 1 ug/ml, respectively, and cultured for 24, 48, 72 hours, and then 5 mg/ml of MTT (3-(4,5- Dimethylthiazol-2-yl)-2,5-diphenyltetrazolinium bromide) reagent 20 μl was added to the culture solution, and cultured at 37° C., 5% CO ₂ under humid conditions for 4 hours.

A culture medium treated with a cell medium in a volume of 200 μl was used as a negative control, and a culture medium treated with 10 μM minoxidil was used as a positive control, instead of the same conditions or samples as above. In culture, purple crystals are formed in living cells. After culturing for 4 hours, the medium was removed, and 100 μl of DMSO was added to melt the crystal in a shaking incubator for 10 minutes, and then the absorbance was measured at 540 nm to measure the degree of cell growth. The results are shown in FIG. 1 .

As shown in the attached FIG. 1, the samples of Examples 1 and 2 improved the growth of hair papilla cells by about 25.3 and 29.8%, and it was confirmed that they exhibited superior hair papilla cell growth promoting activity than the minoxidil-treated group, which is a positive control. In addition, it was confirmed that Example 2 exhibited superior hair papilla cell growth promoting activity compared to Example 1.

On the other hand, it was confirmed that Comparative Examples 1 and 2 using the cassia bark extract and the sadeful extract respectively exhibited a lower hair papilla cell growth promoting activity than the minoxidil treatment group.

(Production Example 1)

With the composition shown in Table 1 below, a shampoo composition was prepared.

At this time, the preparation method is to add polyquater powder and water to the cassia bark extract and sardepool extract, which are the raw materials of group 1, and gradually heat it to about 60~70℃ with a stirrer until the polyquater powder is completely dissolved and becomes transparent. Dissolved and mixed uniformly. Then, the raw material of Group 2 was put into the mixture of Group 1, and then uniformly solubilized and mixed while maintaining 55 to 65° C. using a spechula. Next, after putting the raw materials of Group 3 into the mixture of Group 1 and Group 2, they were uniformly mixed with a hand blender.

In this case, the sample prepared in Example 1 was used for the cassia bark extract and sardine grass extract.

(Production Example 2)

It was carried out in the same manner as in Preparation Example 1, but after mixing the cassia bark extract and the sardine grass extract with the Paracres extract, it was used. At this time, the composition was shown in Table 1 below.

At this time, the Paracres extract was used as the sample prepared in Example 2.

Composition of Preparation Examples 1 and 2 (wt%) division Ingredient name Preparation Example 1 Preparation 2 Group 1 Purified water to 100 to 100 Cassia Bark Extract 3 3 Sardine extract 3 3 Paracres extract - 3 poly quarter 0.5 0.5 Group 2
LES Poly Quarter 25.0 25.0 CDA 5.0 5.0 cocobetain 5.0 5.0 olive surfactant 5.0 5.0 Group 3 olive liquid 0.5 0.5 silk amino acid 5.0 5.0 peptide hs 2.5 2.5 glycerin 2.0 2.0 Betaine 1.0 1.0 panthenol 0.5 0.5 provitamin E 0.5 0.5

(Comparative Preparation Example 1)

It was carried out in the same manner as in Preparation Example 1, except that the cassia bark extract and sardipul extract were not used.

(Test Example 2)

For Preparation Examples 1 and 2 and Comparative Preparation Example 1, the effects on hair loss prevention and hair growth were tested.

The test method was conducted by selecting subjects with alopecia. The subjects were a total of 40 adult men and women with alopecia from 35 to 50 years of age, and after dividing the test subjects into four groups, the first group washed their hair using the shampoo composition of Preparation Example 1 once a day for 3 months. The second group uses the shampoo composition of Preparation Example 2 in the same way, the third group uses the shampoo composition of Comparative Preparation Example 1 in the same way, and the remaining group uses minoxidil as a control according to the prescribed usage and content. After 3 months of use, the results were observed. (One group consisted of 5 males and 5 females.)

To determine the effect, the daily average amount of hair loss, visual judgment, and the degree of improvement in subjective symptoms were evaluated in 5 steps as an evaluation scale, and the overall improvement was taken as the average of the evaluation scales. It was given in units of 1 point.

Test results of Test Example 2. division Preparation Example 1 Preparation 2 Comparative Preparation Example 1 control Visually 3.5 3.7 2.1 2.6 subjective symptoms 3.7 3.9 2.1 2.5 Hair loss when washing hair 3.8 3.9 2.0 2.6 Comprehensive improvement 3.7 3.8 2.1 2.6 1: Worst, 2: Invariant, 3: Slightly improved, 4: Moderately improved, 5: Much improved

As can be seen in Table 2 above, the group using Preparation Examples 1 and 2 of the present invention received significantly better scores than the group using Comparative Preparation Example 1 and the control group in visual, subjective symptoms, number of hair loss, and overall improvement. It was confirmed that the hair loss improvement effect was shown.

(Test Example 3)

For Preparation Examples 1 and 2 and Comparative Preparation Example 1, the effect on scalp itchiness and dandruff relief was tested.

The test method was conducted by selecting subjects with scalp itching and dandruff. The subjects were a total of 30 adult males and females with scalp itching and dandruff up to the age of 35-50 years, and after dividing the subjects into three groups, the first group used the shampoo composition of Preparation Example 1 once a day for 3 months. After washing their hair, the second group used the shampoo composition of Preparation Example 2 in the same way, and the other group used the shampoo composition of Comparative Preparation Example 1 in the same way, and then the results were observed. The group consisted of 5 males and 5 females.)

To determine the effect, the degree of itch relief, the degree of relief from dandruff, and the feeling of stimulation were evaluated in 5 steps as evaluation scales, and the average of the evaluation scales was used, and the score was given in units of 1 point according to the step out of 5 points. .

Test result of Test Example 3. division Preparation Example 1 Preparation 2 Comparative Preparation Example 1 itching relief effect 3.3 4.3 1.8 Dandruff relief effect 3.5 4.1 1.7 stimulus evaluation 1.0 1.0 1.0 1: No effect or irritation at all. 2: There is no effect or stimulation. 3: The effect or irritation is moderate. 4: There is an effect or irritation. 5: There are many effects or stimulation.

As can be seen in Table 3, the group using Preparation Examples 1 and 2 of the present invention had superior itch relief and dandruff alleviation effects compared to Comparative Preparation Example 1, and there was no degree of irritation.

(Test Example 4)

The feeling of use for Preparation Examples 1 and 2 and Comparative Preparation Example 1 was tested.

The subjects were a total of 30 adult females with long straight hair up to 25-35 years of age, and after dividing the subjects into three groups, the first group used the shampoo composition of Preparation Example 1 once a day for a week. to wash their hair, the second group used the shampoo composition of Preparation Example 2 in the same manner, and the remaining groups used the shampoo composition of Comparative Preparation Example 1 in the same manner, and then the results were observed.

For the evaluation of the effect, satisfaction with foamability, gloss, smoothness, feel when used, touch after use, touch after drying, and texture after drying were evaluated. As an evaluation scale, it was evaluated in 5 stages, and the results were expressed as the average, and the score was given in units of 1 point according to the stage on a scale of 5 out of 5.

Test result of Test Example 4. division Preparation Example 1 Preparation 2 Comparative Preparation Example 1 foamy 3.8 3.8 3.8 shine 4.0 4.5 2.9 lubricity 4.1 4.5 3.1 feel when in use 4.0 4.1 3.4 feel after drying 4.1 4.5 3.2 1: Not very good, 2: Somewhat bad, 3: Average, 4: Somewhat good, 5: Very good

As can be seen in Table 4, it was confirmed that when Preparation Examples 1 and 2 of the present invention were used in terms of gloss, smoothness, and tactile feel, a significantly higher score was obtained than when Comparative Example 1 was used.

As described above, although the present invention has been described with reference to limited embodiments and drawings, the present invention is not limited thereto, and the technical spirit of the present invention and the following by those of ordinary skill in the art to which the present invention pertains. Of course, various modifications and variations are possible within the equivalent scope of the claims to be described.

Claims (4)

With respect to 100% by weight of the shampoo composition,
Contains 0.1 to 5% by weight of cassia bark extract, 0.1 to 5% by weight of sardinia extract, and 0.1 to 5% by weight of paracreth extract as active ingredients,
The cassia bark extract and sardipul extract have a hair papilla cell growth promoting activity,
The cassia bark extract, the extract of sardinia, and the paracreth extract are those extracted using water, alcohol or an aqueous alcohol solution,
The alcohol is a shampoo composition for preventing hair loss, characterized in that it is one of methanol, ethanol, propanol, isopropanol and butanol. delete delete delete

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