KR100609210B1 - Shampoo composition for preventing hair loss - Google Patents

Abstract

The present invention relates to a shampoo composition having a hair loss preventing function, which is 0.1 to 10% by weight of the extract extracted by ethanol from Angelica Root, and 0.1 to 5% by weight of the extract extracted by ethanol from Burdock Root usually Beta-cytosterol component contained in Angelica extracts inhibits 5α-reductase in the scalp when combined with the shampoo composition of Provides a "shampoo composition with hair loss prevention function" that can inhibit hair loss by improving the blood flow by the components of inulin contained in burdock root extract and helping cells grow and grow hair by other active ingredients. do.

Angelica Root Extract, Burdock Root Extract, Composition, Shampoo, Hair Loss Prevention

Description

Shampoo composition for preventing hair loss

The present invention relates to a shampoo composition having a hair loss preventing function.

Generally, the number of hair follicles is determined when a person is born, so new hair cannot grow beyond the number of hair follicles. Thus, hair loss is the same as hair consumption.

The most common type of alopecia is male pattern baldness, also known scientifically as androgenetic alopecia. Androgenetic alopecia is shortened by the thinning of healthy hair, and the hair is weak and easily miniaturized, leading to invisible fluffy hair.

Although hair loss is caused by the hair loss gene, androgenic, testosterone, a major male hormone, and its metabolite, DHT, are thought to have a physiological effect of hair loss, which shrinks some hair follicles and stops their activity.

Dihydrotestosterone DHT, known to cause direct hair loss, is a metabolite produced by the action of 5-alpha reductase, an enzyme on testosterone. Is a substance that causes a change. In addition, DHT shortens the growth period and lengthens the rest period of the hair growth cycle, and eventually the hair size becomes smaller as the growth cycle is repeated.

Testosterone affects hair growth, while DHT does not affect hair growth, but only affects beard and hair loss.

In areas where hair loss occurs, the activity of 5-alpha reductase is high. Nowadays, propecia, which is used as a treatment for alopecia, functions to inhibit the enzyme. Women have about half the amount of 5-alpha reductase enzymes compared to men, while they contain a lot of enzymes called aromatase, which are especially found near the hairline of the bangs. Aromatase inhibits the production of DHT, so the type of hair loss in women is different from that in men. Hair loss is also caused by hair follicle shrinkage caused by physical aging.

Minoxidil, a product approved by the US FDA, is a potent vasodilator developed for oral hypertension, and the blood flow of the hair follicle increases due to vasodilation. I noticed that hair growth was accelerated, so it was used to treat alopecia.

Another drug approved by the FDA to treat alopecia is propecia (chemical name: finasteride), which is effective in inhibiting hair loss by inhibiting 5-alpha reductase, which converts testosterone to DHT, the cause of masculine alopecia.

Minoxidil, a hair regrowth agent, is not effective, and propecia has a disadvantage in that side effects such as hair loss proceed again when the dose is stopped.

Known prior art of therapeutic agents for alopecia include compositions containing ginkgo extract and red ginseng extract (Patent No. 2000-38214), compositions containing extracts of orchid fruit plants (patent no. 157663), mung bean flour and soybeans. Compositions containing a flour such as flour and mussel powder (Patent No. 260673), and compositions containing juices such as baekbaekpi, baekbaek leaf and ginger used in herbal medicine (patent 201589) and the like are known. However, until now, the development of a product that prevents hair loss and hair growth has not been actively performed.

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An object of the present invention is to mix hair 0.1% to 10% by weight of the extract extracted by ethanol from Angelica Root and 0.1% to 5% by weight of the extract extracted by ethanol from Burdock Root in a conventional shampoo composition made of a surfactant material When washing, the active ingredient of Angelica Root Extract and Burdock Root Extract inhibits 5α-reductase in the scalp, inhibits the production of DHT related to hair loss, improves blood flow, It is to provide a "shampoo composition having a hair loss preventing function" that can help hair growth by preventing hair loss.
In order to achieve the above object, the present invention is characterized by containing the Angelica Root Extract and Burdock Root extract in the shampoo composition.
Angelica Root Extract and Burdock Root Extract are extracts prepared by extracting 100% by weight of Angelica Root and Burdock Root with 500 to 1000% by weight of an ethanol aqueous solution at a concentration of 30 to 100%. When the hair extract is extracted from Angelica Root and Burdock Root, it is blended with a normal shampoo brother made of a surfactant material. Inhibits the production of dihydrotestosterone (DHT), which is associated with hair loss by inhibiting 5α-reductase, and improves blood flow by the components of inulin in the active ingredient contained in the burdock root extract. It is a shampoo composition having a hair loss preventing function that promotes cell growth and hair growth by ingredients, thereby preventing hair loss.
Angelicae Gigantis Radix adopted in the present invention is a perennial herb belonging to the Apiaceae, about 80-90 cm high, the leaves are lanceolate, and have sharp teeth on the edges. White flowers bloom in August-September. Fruits are oval, with wings at the edges, and breed as seeds. In oriental medicine, the root of Seunggeumcho has been used as a valuable medicine since ancient times. The essential components of Angelica are essential oils, tacusin, sedating beta cytosterol, and other sucrose, nicotinic acid, folic acid, vitamin E, vitamin A, vitamin B12, and coumarin derivatives.
Vitamin B2, which is abundant in the genus, is also called Riboflavin, which plays a very important role in the metabolism of the soft tissues of the human body. In part of the tissue to replace the oxygen in other neighborhoods, and also to help the assimilation and metabolism of starch and sugar. Several scientific studies have shown that vitamin B2 does not give luster and smooth hair injuries change the cycle of hair growth and start hair loss.
In addition, beta-cytosterol component has an important function of inhibiting 5-alpha reductase in the body to prevent DHT from forming during the metabolism of male hormones.
Burdock (Arcium lappa L.) is a relatively high-temperature crop, with a growth temperature of 20-25 ° C. The upper part dies at 3 ° C, but sprouts again in spring. Burdock is extremely resistant to cold, so it is possible to cultivate spring and fall sowing. Burdock's hypertrophy area is main root and large neck with radish and turnip.
Roots are deep and straight, 40-150 cm long, depending on the variety. The surface of the leaf is green, but there is a white down on the back, which makes it look white. Burdock is high in sugar and most of it is inulin. There is also a lot of fiber and calcium and phosphorus. It has been widely used as a folk medicine since ancient times, and it is known to be effective for the treatment of skin diseases and boils.
Recently, lignin contained in burdock root has been found to inhibit the development of cancer cells by antibacterial action. In addition, because it plays an important role in the excretion of harmful substances such as carcinogens, it is known to be effective for the prevention of colon and rectal cancer. Inulin has been shown to increase the function of the kidneys, have a diuretic effect, have a continuous hypoglycemic effect, and have low toxicity to the critical amount of carbohydrates. Tannins contained in burdock roots are applied to the affected areas by anti-inflammatory, hemostatic, and antibacterial action, and when bathed in water, they are stung by bees, sweat bands, contact dermatitis, and eczema. In particular, fiber, such as cellulose and lignin, which are found in burdock, has the property of promoting the synthesis of vitamins simultaneously, which promotes bowel movements and helps the development of intestinal bacteria. Eating burdock cleanses blood and softens skin. It has been noted that it is effective in gangjeong and tonic, and helps secrete sex hormones.
Burdock also promotes metabolism, helps blood circulation, and acts to get old blood out. Unlike other ingredients, burdock's main component, starch, is low in starch and is composed of a component called inulin, which helps the kidneys to smoothly excrete waste products. It also contains a lot of vegetable fiber to eliminate constipation and prevent blood pressure from rising. The metabolism of the body is made by the action of these ingredients and the blood circulation is improved, so it is effective in stroke. Burdock contains vitamins B1, B2, and niacin, which help cells grow, replace oxygen in other parts of the tissue, and help metabolism by improving blood flow.
In the present invention, by using together the Angelica Root Extract and Burdock Root Extract when used alone to increase the hair loss prevention effect. The content of Angelica Root Extract and Burdock Root Extract in the shampoo composition is preferably 0.1 to 10% by weight, and the content of 0.1% by weight or less is less effective in preventing hair loss, and more preferably 0.1 to 5% by weight.
In the present invention, the hair loss prevention shampoo composition containing the Angelica Root Extract and Burdock Root Extract comprises a surfactant selected from anionic surfactants, nonionic surfactants, amphoteric surfactants, or mixtures thereof. Suitable anionic surfactants include alkyl sulfates, alkyl ether sulfates, alkarylsulfonates, alkyl succinates, alkyl sulfosuccinates, N-alcohol sarcosinates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, and Alpha-olefinsulfonates, especially their sodium, magnesium, ammonium and mono-di, and triethanolamine salts. Generally, alkyl groups are 8 to 18 carbon atoms and may be unsaturated. It may comprise 1 to 10 ethylene oxide or propylene oxide units per molecule of alkylethersulfate, alkyletherphosphate and alkylethercarboxylate, preferably including 2 or 3 ethyleneoxide units per molecule.
Examples of suitable anionic surfactants are sodium oleum succinate, ammonium laurylsulfosuccinate, ammonium lauryl sulfate, sodium dodecylsulfonate, triethanolamine dodecylbenzenesulfonate and sodium N-lauryl sarcosinate. Most preferred anionic surfactants are sodium lauryl sulfate, triethanolamine aruryl sulfate, triethanolamine monolauryl phosphate, sodium lauryl ether sulfate (EO addition mole number = 1-3), ammonium lauryl sulfate, and ammonium lauryl ether sulfate ( EO addition mole number = 1-3).
The anionic surfactant is preferably present in the composition of the present invention in an amount of 20 to 50% by weight, most preferably 30 to 40% by weight.
Suitable nonionic surfactants for use in the present invention are mono- or di-alkylalkanolamides. Examples are cocomono- or di-ethanolamide and coco mono-isopropanolamide.
Amphoteric surfactants suitable for use in the present invention include alkylamine oxides, alkylbetaines, alkylamidepropylbetaines, alkylsulfobetaines, alkylglycinates, alkylcarboxyglycinates, alkylamphopropionates, alkyls Amidepropylhydroxysulfyne, acyltaurate, and acyl glutamate. Here, the alkyl and acyl group has 8 to 18 carbon atoms. Examples include lauryl amine oxide, cocodimethylsulfopropylbetaine, with laurylbetaine, cocoamidopropylbetaine, and sodium cocoampopropionate being preferred.
The amphoteric surfactant is preferably present in the shampoo composition of the present invention in an amount of 2 to 40% by weight, most preferably 5 to 30% by weight.
Shampoo compositions according to the invention contain an aqueous emulsion of a high viscosity silicone solution in a volatile solvent. The emulsion is formed by first dissolving high viscosity silicone in a volatile solvent and then adding and mixing an emulsifier and water. The high viscosity silicone is preferably selected from silicone resins or siloxane gums or mixtures thereof. Suitable resins form a film when the volatile silicone solvent is removed by evaporation. These membranes are hard and brittle at room temperature but soften when heated. Resin is suitable for the temperature at which softening starts at 30 degreeC or more. The silicone resin preferably has an average molecular weight of 500 to 10,000.
Examples of silicone resins useful in the composition of the present invention are Shintsu Silicone MK (Wacker) and MQ resins (General Electric). Shin-Etsu Silicone MK is a silsesquioxane resin. Resin MQ is obtained by reacting trimethylchlorosilane or nuxamethyldisilane with silicic acid or polysilicic acid in the presence of a weak acid in a solvent.
Suitable siloxane gums for use in the shampoo compositions of the present invention include high molecular weight alkylpolysiloxanes, arylpolysiloxanes and alkylpolysiloxanes having a viscosity of at least 100,000 centistokes (cSt), preferably at least 500,000. Examples of suitable siloxane gums are SE30 and SE76 produced by General Electric. These gums are polydimethylsiloxane gums with a large viscosity of at least 1 million centistokes.
The emulsion contains particles of a high viscosity silicone solution having an average particle size of less than 2 μm, preferably 0.01 to 1 μm. Average particle size can be measured by laser light scattering technique using a 2600D Particle Sizer supplied from Malvern Instruments. Generally, high viscosity silicone is 0.1 to 5% by weight, preferably 0.3 to 1, based on the total amount of the shampoo composition. Present in weight percent. High viscosity silicone is dissolved in volatile solvents. As used herein, the term volatility means having a measurable vapor pressure. Those having a boiling point of 99 to 260 ° C and a solubility in water of less than about 0.1% are preferred solvents. These solvents are preferably selected from volatile silicones or volatile hydrocarbons. The most preferred solvent is silicone, which may be a cyclic or linear polydimethylsiloxane. The number of silicon atoms in the cyclic silicon is 3 to 7, more preferably 4 or 5, and the viscosity is less than 10 centipoise (cp) at 25 ° C.
In general, linear poly dimethylsiloxanes useful in the present invention have a viscosity at 25 ° C. of less than about 5 cps. Linear volatile silicones contain from about 3 to 9 silicon atoms and from 244, 245, 344, 345, and 200 fluids (cyclopolymethylsiloxane mixture 0, 200/5 floyd (very short linear poly) from Dow Corning Dimethylsiloxane) and 1401 floid (a mixture of gums of polydimethylsiloxane and cyclopolydimethylsiloxane); TP503 floid (emulsion of polydimethylsiloxane gum in cyclopolymethylsiloxane) and starwoo chemical from Union Carbide Chemical) is widely available as SWS-03314.
Surfactant materials can be used alone or in mixtures as emulsifiers in the preparation of silicone resin emulsions. Preferred emulsifiers are alkylarylsulfonates, for example sodium dodecylbenzenesulfonate, alkylsulfate, sodium lauryl sulfate, alkyl ethers, sodium lauryl ether sulfate nEO, where n is 1-20, alkylphenolethersulfate, octylphenol Ether sulfate nEO, where n is 1-20, and anionic emulsifiers such as sulfosuccinate, sodium dioctyl sulfosuccinate. In addition, alkyl phenol ethoxylate, nonylphenol ethoxylate nEO (where n is from 1 to 50), alcohol ethoxylate, lauryl alcohol nEO (where n is from 1 to 50), ester ethoxylate, polyoxy Suitable are nonionic emulsifiers, such as ethylene monostearate, wherein the number of oxyethylene units is 1-30. The emulsion is preferably contained in the sampu composition in an amount of 0.5 to 50% by weight, more preferably 1 to 20% by weight. The content of the emulsion is effective to provide the desired amount of silicone in the final composition.
The shampoo composition of the present invention also contains a cationic conditioning polymer which is a cationic guar gum derivative. Suitable cationic guar gum derivatives are those given as CTFA-designated guarhydroxypropyltriammonium chlorides, which are commercially available as zaguar, for example JAGUAR C13S, whose cationic group has a low degree of substitution and viscosity. Is high. Other suitable materials include hydroxypropylated cationic guar containing low levels of substituents as well as low levels of substituents, as well as Zaguar C15, Zaguar C17 (high substitution high viscosity) and cationic quaternary ammonium groups with moderate degree of substitution and low viscosity. There is a derivative, zaguar C16. Suitable materials include zaguar 162, a highly transparent medium viscosity guar with low degree of substitution.
In the present invention the composition may contain from about 0.01 to 1% by weight, preferably from about 0,04 to 05% by weight of the cationic conditioning polymer.
In addition, the compositions of the present invention may optionally further contain a suspending agent that can act to suspend the particulate matter in the shampoo composition. Suitable suspending agents can be obtained from Xanthan gum, guar gum, and optionally from crosslinked acrylic acid polymers (e.g., Carbople 940 or 1342 from Goodrich). Or gums such as esters of polyethylene glycol.
In addition, the shampoo composition of the present invention may additionally contain trace amounts of other components found in conventional shampoo compositions, such as antibacterial agents, anti-dandruff agents such as zinc pyridion or octopirox, foam accelerators, fungal gloss agents, perfumes, Dyes, colorants, preservatives, viscosity modifiers (for example thickening agents such as sodium chloride or ammonium chloride), moisturizing agents such as proteins, polymers, buffers, polyols.

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Hereinafter, the present invention will be described in detail with reference to Examples.

Example 1 (Preparation of Angelica Root Extract)

1 g of ethanol with a concentration of 70% was added to 200 g of dried Angelica Root Extract powder and stirred well. Then, the mixture was refluxed for 3 hours at an extraction temperature maintained at 70 to 90 ° C., and the filtrate was separated. The extract was concentrated under reduced pressure, and then lyophilized to obtain 20 g of the herbal composition powder extract.

Example 2 (Preparation of Burdock Root Extract)

As in Example 1, 1 g of ethanol having a concentration of 705 was added to 200 g of dried burdock root extract powder, stirred well, and heated to reflux for 3 hours at an extraction temperature of 70 to 90 ° C., and the filtrate was separated. The herbal extracts were concentrated under reduced pressure at ˜65 ° C., and then lyophilized to obtain 17 g of the herbal composition powder.

Comparative Example 3 and Example 4

Based on the conventional shampoo formulation, Comparative Example 3 of the shampoo containing the Angelica Root Extract and Burdock Root Extract prepared in Examples 1 and 2 and Example 4 of the shampoo containing the extract of the present invention are shown in Table 1. As indicated.

Table 1

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The shampoo composition of the invention is applied to wet hair in an amount of 3 to 5 ml. Rub wet hair and foam. The foam is left to rest for a short time, for example 1 to 4 minutes, before rinsing and then rinsed. Repeat your hair as needed.

Example 5 (Clinical Experiment)

The following clinical trials were conducted in 64 men over 25 years of age who had never been treated before. It was to be used more than four times a week, and the control group was to use the shampoo composition of Comparative Example 3 of Table 1 that does not contain the Angelica Root Extract and Burdock Extract of the present invention for 3 weeks, and another group of the Angelica Root Extract of the present invention The shampoo composition of Example 4 containing the burdock root extract was used.

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상기 표에서 비교예의 샴푸 조성물을 사용한 대조군에서는 48명이 탈모현상이 나타나고 11명이 탈모현상 중지가 나타난 반면, 실시예 4의 본 발명의 샴푸 조성물을 사용한 치료군에서는 37명이 양모형상이 나타나고 21명이 머리카락이 굵어졌으며 4명이 탈모중지 현상이 나타났다.
상기 표 2에서 보는 바와 같이 본 발명의 당귀뿌리 추출물과 우엉뿌리 추출물이 함유된 샴푸 조성물은 탈모를 방지하고 양모와, 머리카락이 굵어지는 확실한 효과가 있음을 임상실험에 의해 확인되었다.The clinical trial results are shown in Table 2.
Table 2

In the control group using the shampoo composition of the comparative example in the table, 48 hair loss phenomenon and 11 hair loss phenomenon appeared, while in the treatment group using the shampoo composition of the present invention of Example 4 37 wool appearance and 21 hair thickening 4 patients had hair loss.
As shown in Table 2, the shampoo composition containing the Angelica Root Extract and Burdock Root Extract of the present invention was confirmed by clinical experiments to have a definite effect of preventing hair loss and thickening of wool and hair.

The present invention washes the hair by combining 0.1 to 10% by weight of the extract extracted with methanol from Angelica Root and 0.1 to 5% by weight of the extract extracted with Ethanol from Burdock Root in a conventional shampoo composition made of a surfactant material (洗淨) Beta-cytosterol component in Angelica extract inhibits 5α-reductase in the scalp, inhibits the production of dihydrotestosterone (DHT) related to hair loss, and the component of inulin in burdock root extract By improving the blood flow by and help the growth and growth of hair by the other active ingredients, hair loss and the thickening of wool and hair has the effect.

Claims (6)

Hair loss prevention shampoo composition comprising the extract of Angelica Root and Burdock Root as an active ingredient in a conventional shampoo composition The anti-hair loss shampoo composition according to claim 1, wherein the extract of Angelica Root is contained in an amount of 0.1 to 10% by weight. Hair loss prevention shampoo composition according to claim 1, wherein the burdock root extract is contained in an amount of 0.1 to 10% by weight. The anti-hair loss shampoo composition according to claim 1 or 2, wherein the Angelica extract is prepared by extracting with ethanol having a concentration of 70%. The anti-hair loss shampoo composition according to claim 1 or 3, wherein the burdock root extract is prepared by extracting with ethanol having a concentration of 70%. The composition of claim 1, wherein the formulation of the composition is a shampoo, rinse, lotion, cream, soap, emulsion, esensor, spray type hair loss prevention shampoo composition.