KR20040031407A - Sampoo composition for preventing hairloss - Google Patents

Abstract

PURPOSE: Provided is a shampoo composition for the prevention of depilation, which contains, as an active ingredient, the root extract of Angelica gigas Nakai or Arctium lappa L. Therefore, the composition helps the metabolism of hair to prevent depilation. CONSTITUTION: A shampoo composition for the prevention of depilation contains, as an active ingredient, 0.1-10 wt.% of the root extract of Angelica gigas Nakai or Arctium lappa L. The extract is obtained by extracting 100 parts by weight of the root of Angelica gigas Nakai or Arctium lappa L. with 500-1000 parts by weight of an ethanol solution containing 30-100 wt.% of methanol.

Description

Shampoo composition for preventing hair loss {Sampoo composition for preventing hairloss}

The present invention relates to a hair loss prevention shampoo composition comprising a plant extract as an active ingredient.

Numerous studies have been conducted to determine the cause of hair loss, but only recently, as the structure of genes and sex hormones became known, the cause of hair loss was identified. One thing is clear: no matter what you eat, what your lifestyle is, what medicines or vitamins you take, no new hair can grow beyond the number of hair follicles you have had since birth.

The most common type of hair loss is male pattern baldness, which is called androgen alopecia and is a more accurate and scientific name. In the case of androgenetic alopecia, healthy hair becomes thinner, shorter, and weaker, causing hair to break easily. This phenomenon is called miniaturization. Hair follicles, which shrink, eventually become thin, invisible, turn into short hairs, and hair loss progresses.

Androgenetic alopecia, or so-called baldness, only occurs if you have the alopecia gene. The hair loss gene can be multiplied in either parent. A gene is a single chemical structure located on one part of a chromosome and consists of small pieces of DNA. Chromosomes always exist in pairs, and in humans there are 23 pairs of chromosomes, one inherited from the parent. The genetic form of androgenetic alopecia is not simple, and at least one gene is known to be involved in the expression of alopecia. When multiple genes are involved, this is called multifactorial inheritance.

Human chromosomes are composed of a pair of sex chromosomes (XX, or XY) and 22 pairs of autosomal chromosomes. The genes that cause hair loss are known to have autosomal inheritance. Thus, the gene for hair loss can be inherited from either the mother or the father. In other words, the genetic factor of hair loss can be inherited by either the parent or the other, but the mother's gene has a more important meaning. The gene that causes hair loss is dominant, so it can be expressed by having only one of a pair of genes.

Not everyone with baldness genes is bald. What actually happens when you have a gene is called expresivity, and the expression of hair loss actually correlates with factors such as hormones, age, and stress. Many fathers and uncles are not necessarily deprived of their hair loss because they do not inherit the genes, or because they do not have enough expression. To date, it is difficult to identify the gene causing hair loss.

Testosterone, a major male hormone, and many other related male hormones are primarily produced in the testicles, which are produced in earnest when puberty develops, resulting in thick voices, beards, muscle development, and masculinity. Will change to body shape. These hormones, which are also the cause of acne, are the hormones that cause hair loss.

Androngen, or testosterone and its metabolite, DHT, contracts some hair follicles and stops their activity. These hormones can also cause hair loss in women. Androgenic hormones are also secreted by the adrenal glands located next to the kidneys. In women, the ovaries also secrete hormones that affect hair.

The hormone that directly causes hair loss is known as dihydrotestosterone (DHT). DHT is a metabolite produced by the action of 5-alpha reductase, an enzyme called testosterone, which binds to specific parts of hair follicle cells and causes a series of changes associated with hair loss. In addition, DHT shortens the growth period and lengthens the rest period of the hair growth cycle, and eventually the hair size becomes smaller as the growth cycle is repeated.

Testosterone affects the growth of armpit hair and pubic hair, while DHT affects beards and baldness. However, it does not affect hair growth, but only hair loss.

In the area where hair loss occurs, the activity of 5-alpha reductase enzyme is high. Nowadays, propecia, which is used as a treatment for alopecia, acts to inhibit this enzyme. Women have only half of the five-alpha reductase enzymes compared to men, while they contain a lot of enzymes called aromatase, which are especially found near the hairline of the bangs. Aromatase inhibits the production of DHT, so the type of hair loss in women is different from that in men.

Having both genes and hormones does not necessarily mean hair loss. To become alopecia, hair follicles with genetic predisposition must be exposed to hormones for a certain period of time. The duration of exposure varies from person to person and depends on the expression and blood levels of the individual genes.

Hair loss does not fall out all at once, and also does not continue at a constant rate, but the rate of hair loss goes through the early, late, and stabilizing periods. But as you get older, the total number of hairs must decrease.

Even people without hair loss genes will shrink in some follicles as they get older. The result is a mixture of coarse and thin hairs, and the overall appearance is thin. Eventually, the reduced hair follicles cease to function, causing the hair to disappear and reducing the number of hair follicles. Hair loss due to aging occurs throughout the scalp, and the back hair used as a donor for hair transplantation is not an exception and becomes thinner as aging progresses.

Among the external preparations used to treat androgenetic alopecia to date, there is an external preparation, minoxidil, which is currently applied by a US FDA-approved product.

Minoxidil is a potent vasodilator that was originally developed as an oral antihypertensive drug. By the way, the body of high blood pressure patients who took this medicine for a long time found abnormal hair growth, and made it into powder and experimented with it externally to confirm that hair growth was promoted and developed as alopecia treatment. . Minoxidil, a vasodilator, is known to treat hair loss through mechanisms such as promoting hair growth, increasing hair volume, extending hair growth stages, and increasing blood flow to hair follicles in areas where hair loss occurs.

As another treatment for alopecia, finasteride is currently the only FDA-approved drug to treat hair loss. Since the 1950s, studies on androgen (androgens), known to be involved in androgenetic alopecia, have led to the development of a new drug that works against androgenetic alopecia called finasteride.

Propesia (finasteride) has an effect on hair loss by inhibiting the 5-α reductase that converts testosterone to DHT, the cause of male hair loss. Due to the action of these drugs, propecia (finasteride) is forbidden to be administered to children or women.

As such, Minoxidil, a hair loss preventer that is even recognized by the US FDA, does not have a clear effect, and propecia (finasteride) stops taking the drug and causes hair loss again. .

In addition to minoxidil and propecia, a composition containing ginkgo extract and red ginseng extract as a hair regrowth agent (Korean Patent Publication No. 2000-38214), a composition containing an extract of orchid family (Korean Patent No. 157667), green flour powder and soybean flour, etc. Compositions containing mussel powder and the like (Korean Patent No. 260673) and compositions containing juices such as baekbaekpi and baekhyeop and ginger used in herbal medicine (Korean Patent No. 201589) are known, but there are still certain prevention of hair loss and hair growth. The development of the product is not made actively.

The present invention in consideration of the problems of the prior art by inhibiting the 5-α reducing enzyme in the body to prevent DHT formation in the metabolic process of male hormones, and to improve the blood flow of the scalp to help the hair metabolism action It is an object to provide a shampoo composition that can be used to prevent hair loss.

The present invention provides a hair loss prevention shampoo composition comprising the Angelica Root Extract and Burdock Root Extract to achieve the above object. Preferably, the extract of Angelica Root Extract and Burdock Root Extract are prepared by extracting 100 parts by weight with 500 to 1000 parts by weight of a solvent of an ethanol solution of 30 to 100% by weight of ethanol.

Hereinafter, the present invention will be described in detail.

Angelicae Gigantis Radix is a perennial herb belonging to the Buttercup family, originally native to deep mountains, but cultivated today. Its height is about 80 ~ 90cm, leaves are lanceolate, and have sharp teeth on the edge. White flowers bloom in August-September. Fruits are elliptical with wings at the edges. Breeding is done with seeds. In oriental medicine, the root of Seunggeumcho has been used as a valuable medicine since ancient times. The main components of Angelica are essential oils such as essential oils, tekushin, and sedating beta sitosterol, and other components such as sucrose, nicotinic acid, folic acid, vitamin E, vitamin A, vitamin B12, and coumarin derivatives.

Vitamin B2, which is abundant in Angelica, is also called Riboflavin, which plays an important role in the metabolism of the soft tissues of the human body. In addition to the role of replacing the oxygen in other parts of the tissue also helps the assimilation and metabolism of starch and sugar. Various scientific studies have reported that vitamin B2 is not given the luster and smooth hair injuries change the cycle of new hair growth and hair loss begins.

Angelica in oriental medicine is an important drug for the treatment of anemia, and has an effect of improving the state of red blood cells and has good effects on patients with anemia due to iron deficiency, reduction of hemoglobin, deficiency of red blood cells, hypoglycemia and the like. Angelica also has a good effect on menstrual adjustment. The symptoms of dysmenorrhea, defecation, excessive menstruation, dysmenorrhea, lethargy, etc. can be treated mainly by donkeys, and have the effect of removing blood blood as well as the action of blood. By using donkeys for abdominal pain and bloating caused by fish blood, bloating, angina, etc., the coronary artery can be enlarged and the resistance of blood vessels can be reduced to accelerate the speed of blood flow.

In addition, the beta-cytosterol component has an important function of inhibiting the 5-a reductase in the body to prevent the formation of DHT during the metabolism of male hormones.

Burdock (Arcium lappa L.) is a relatively high-temperature crop, with a growth temperature of 20-25 ° C. The upper part dies at about 3 ° C, but sprouts again in spring. Burdock is extremely resistant to cold, so it is possible to cultivate spring and fall sowing. Burdock's hypertrophy area is freckles, and the neck is large with radish and turnip. Roots are deep and straight, with a shape and length depending on the variety, but 40-150 cm long depending on the variety. The surface of the leaf is green, but there is a downy feather on the back, which makes it look white.

Burdock is mainly used in Korea and Japan, and is not grown in Europe or China, but uses some wild ones. Burdock can also be boiled or dried. Burdock has a lot of sugar and most of it exists as Inulin. There is also a lot of fiber and calcium and phosphorus. It has been widely used as a folk medicine since ancient times, and it is effective for the treatment of skin diseases and boils.

Recently, it has been found that lignin contained in the root of burdock inhibits the development of cancer cells by antibacterial activity. In addition, because it plays an important role in the excretion of harmful substances such as carcinogens, it is known as an effective plant for the prevention of colon and rectal cancer.Inulin has a diuretic effect, a continuous hypoglycemic effect, and an increase in carbohydrate allowance. It is known to have low toxicity. Burdock root contains tannins, which are anti-inflammatory. Hemostatic, bactericidal effect applied to the affected area or bathed in water is effective for sweating, contact dermatitis, eczema, etc. In particular, cellulose, such as cellulose and lignin, which are found in burdock, have the property of absorbing moisture to promote bowel movements, aiding in the formation of aerobic bacteria in the intestine, and at the same time, promoting the synthesis of vitamins. Eating burdock cleanses blood and softens rough skin. It is attracting attention because it is effective in gangjeong and tonic, and helps in secreting sex hormones.

Burdock also promotes metabolism and helps blood circulation, which helps to get old blood out. Unlike other sugars, burdock's main component is low starch and most of it consists of inulin, which helps the kidneys to smoothly excrete waste products. It also contains a lot of vegetable fiber to eliminate constipation and prevent blood pressure from rising. The metabolism of the body is made by the action of these ingredients and the blood circulation is also improved, which is effective for stroke. Burdock contains vitamins B1, B2 and niacin, which help cells grow, replace oxygen in other parts of the tissue, and help metabolism by improving blood flow.

The present invention is the use of the Angelica Root Extract and Burdock Root Extract is due to the increase in hair loss preventing effect by using together when used alone. The content of each extract is preferably 0.1 to 10% by weight, the content of 0.1% by weight or less has a low hair loss prevention effect. The content of Angelica Root Extract and Burdock Root Extract is preferably 0.1 to 5% by weight, respectively.

The shampoo composition using the above anti-hair loss component contains a surfactant selected from anionic surfactants, nonionic surfactants or amphoteric surfactants or mixtures thereof. Suitable anionic surfactants include alkyl sulfates, alkyl ether sulfates, alkaryl sulfonates, alkyl succinates, alkyl sulfosuccinates, N-alcoyl sarcosinates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates and Alpha-olefin sulfonates, especially their sodium, magnesium, ammonium and mono-, di- and triethanolamine salts. Generally, alkyl groups have 8 to 18 carbon atoms and may be unsaturated. Alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates may comprise from 1 to 10 ethylene oxide or propylene oxide units per molecule, preferably including 2 or 3 ethylene oxide units per molecule.

Examples of suitable anionic surfactants are sodium oleyl succinate, lauryl sulfosuccinate, ammonium lauryl sulfate, sodium dodecyl benzene sulfonate, triethanolamine dodecyl benzene sulfonate and sodium N-lauryl sarcosinate. Most preferred anionic surfactants are lauryl sulfate, triethanolamine lauryl sulfate, triethanolamine mono lauryl phosphate, lauryl ether sodium sulfate 1EO, 2EO and 3EO, lauryl ammonium sulfate and lauryl ether ammonium sulfate 1EO, 2EO And 3EO. In the shampoo composition of the present invention, the anionic surfactant is preferably present in an amount of 20 to 50% by weight, most preferably 30 to 40% by weight.

Suitable nonionic surfactants for use in the compositions of the present invention include aliphatic (C8-C18) primary or secondary linear or branched chain alcohols or condensation products of phenols with alkylene oxides, usually ethylene oxide, And generally 6 to 30 ethylene oxide groups.

Other suitable nonionic surfactants are mono- or di-alkyl alkanol amides. Examples are coco mono- or di-ethanol amides and coco mono-isopropanol amides. Amphoteric surfactants suitable for use in the compositions of the present invention include alkyl amine oxides, alkyl betaines, alkyl amido propyl betaines, alkyl sulfo betaines, alkyl glycinates, alkyl carboxy glycinates, alkyl amphopros Cypionate, alkylamido propyl hydroxysultine, acyltaurate and acyl glutamate, wherein the alkyl and acyl groups have from 8 to 18 carbon atoms. Examples are lauryl amine oxide, cocodimethyl sulfopropyl betaine, with lauryl betaine, coamidopropyl betaine and coco ampopropionate preferred. In the shampoo composition of the present invention, the surfactant is preferably present in an amount of 2 to 40% by weight, most preferably 5 to 30% by weight.

Shampoo compositions according to the invention contain an aqueous emulsion of a high viscosity silicone solution in a volatile solvent. The emulsion is formed by first dissolving high viscosity silicone in a volatile solvent and then adding and mixing an emulsifier and water. The high viscosity silicone is preferably selected from silicone resins or siloxane gums or mixtures thereof. Suitable resins form a film when the volatile silicone solvent is removed by evaporation. These membranes are hard and brittle at room temperature but soften when heated. Resin whose temperature at which softening starts is 30 degreeC or more is suitable. The silicone resin preferably has an average molecular weight of 500 to 10,000. Examples of silicone resins useful in the compositions of the present invention are silicone Harz MK (Wacker) and MQ resins (General Electric). Silicone Harz MK is a silsesquioxane resin. Resin MQ is obtained by reacting trimethyl chlorosilane or hexamethyl disilane with silicic acid or polysilicic acid in the presence of a weak acid in a solvent.

Suitable siloxane gums for use in the shampoo compositions of the present invention are high molecular weight alkyl polysiloxanes, aryl polysiloxanes and alkyl aryl polysiloxanes having a viscosity of at least 100,000 centistokes (cSt), preferably at least 500,000. Examples of suitable siloxane gums are SE30 and SE76, available from General Electric. These gums are poly dimethylsiloxane gums with a large viscosity of at least 1 million centistokes.

The emulsion contains particles of a high viscosity silicone solution having an average particle diameter of less than 2 μm, preferably 0.01 to 1 μm. Average particle size may be measured by laser light scattering technique using a 2600D Particle Sizer supplied from Malvern Instrument. Generally, the high viscosity silicone is present in an amount of 0.1 to 5% by weight, preferably 0.3 to 1.5% by weight, based on the total amount of the shampoo composition. High viscosity silicone is dissolved in volatile solvents. As used herein, the term volatility means that the material has a measurable vapor pressure. Preferred solvents are those having a boiling point of 99 to about 260 ° C. and a solubility in water of less than about 0.1%. These solvents are preferably selected from volatile silicones or volatile hydrocarbons. Most preferred solvent is volatile silicone, which may be cyclic or linear poly dimethylsiloxane. The number of silicon atoms in the cyclic silicon is 3 to 7, more preferably 4 or 5, and the viscosity is less than 10 centipoise (cp) at 25 ° C. Generally linear poly dimethylsiloxanes useful in the present invention have a viscosity at 25 ° C. of less than about 5 cps. Linear volatile silicones contain from about 3 to about 9 silicon atoms and from 244, 245, 344, 345 and 200 fluids (cyclopolymethylsiloxane mixture), 200/5 fluids (very short linear polydimethyls) from Dow Corning Siloxane) and 1401 fluid (a mixture of poly dimethylsiloxane with gum and cyclo poly methylsiloxane); TP503 fluid (emulsion of poly dimethylsiloxane gum in cyclo polymethylsiloxane) from Union Carbide and SWS-03314 from Stauper Chemical are widely available.

Surfactant materials can be used alone or in mixtures as emulsifiers in the preparation of silicone resin emulsions. Preferred emulsifiers are alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate, alkyl sulfates such as sodium lauryl sulfate, alkyl ether sulfates such as lauryl ether sodium sulfate nEO where n is from 1 to 20 ), Alkyl phenol ether sulfates such as octyl phenol ether sulfate nEO, where n is 1-20, and sulfosuccinates, for example anionic emulsifiers such as sodium dioctyl sulfosuccinate. . In addition, alkyl phenol ethoxylates such as nonyl phenol ethoxylate nEO where n is 1 to 50, alcohol ethoxylates such as lauryl alcohol nEO where n is 1 to 50 Nonionic emulsifiers are suitable, for example, ester ethoxylates such as polyoxy ethylene mono stearate, wherein the number of oxy ethylene units is 1-30. The emulsion is preferably contained in the shampoo composition in an amount of 0.5 to 50% by weight, more preferably 1 to 20% by weight. The amount present in the emulsion is an amount effective to provide the desired amount of silicone in the final composition.

In addition, the shampoo composition of the present invention contains a cationic conditioning polymer which is a cationic guar gum derivative. Suitable cationic guar gum derivatives are those given as CTFA-designated guar hydroxy propyl trimonium chlorides, which are commercially available as zaguar, for example JAGUAR C13S, with a low degree of substitution of the cationic group. , The viscosity is high. Other suitable materials include hydroxypropylated cationic containing Zaguar C15, Zaguar C17 (high substitution, high viscosity) and cationic quaternary ammonium groups, which have moderate degrees of substitution and low viscosity, as well as low levels of substituents. Zaguar C16, a guar derivative. Suitable materials also include zaguar 162, which is a high transparency medium viscosity guar with low degree of substitution. The compositions of the present invention may contain from about 0.01% to about 1%, preferably from about 0.04% to about 0.5% by weight of cationic conditioning polymer.

In addition, the compositions of the present invention may optionally further contain a suspending agent that can act to suspend the particulate matter in the shampoo composition. Suitable suspending agents include xanthan gum, guar gum, optionally cross-linked polymers of acrylic acid (available from Goodrich, for example, Carboful 940 or 1342), esters of ethylene glycol or polyethylene glycol And gums such as esters.

In addition, the shampoo composition of the present invention may further contain trace amounts of other ingredients found in conventional shampoo compositions, such as antibacterial agents, dandruff inhibitors such as zinc pyridinethione or octopirox, foam promoters, pearlescent agents Fragrances, dyes, colorants, preservatives, viscosity modifiers (eg thickeners such as sodium chloride or ammonium chloride), proteins, polymers, buffers, polyols and other moisturizers.

The present invention will be described in more detail with reference to the following examples.

Among the raw materials used in the following Examples, the Angelica Root Extract and the Burdock Root Extract used varieties grown in pure Korea.

Example 1 (Preparation of Angelica Root Extract)

200 g of dried Angelica Root Extract powder is soaked in 1.5 L ethanol for 2 weeks. The mixture was refluxed for 3 hours and then cooled to filter the solution, and the remainder was reextracted twice with 1 liter of ethanol in the same manner. Each filtrate was mixed and concentrated in a 500 ml rotary evaporator. The concentrated solution was added to 2.5 liters of distilled acetone, and the precipitate formed was separated and purified from acetone. The precipitate was evaporated under reduced pressure for 3 hours and then stored in a drier. Yield was 20 g.

Example 2 (burdock root extract preparation)

200 g of dried burdock root extract powder is soaked in 1.5 L ethanol for 2 weeks. The mixture was refluxed for 3 hours and then cooled to filter the solution, and the remainder was reextracted twice with 1 liter of ethanol in the same manner. Each filtrate was mixed and concentrated in a 500 ml rotary evaporator. The concentrated solution was added to 2.5 liters of distilled acetone, and the precipitate formed was separated and purified from acetone. The precipitate was evaporated under reduced pressure for 3 hours and then stored in a drier. Yield was 17 g.

Comparative Example 3 and Example 4 (anti-hair loss shampoo composition)

Based on the conventional shampoo formulation, the hair loss preventing composition of the shampoo formulation of Table 1 including the extract prepared in Examples 1 and 2 was prepared by mixing in a conventional shampoo preparation method.

TABLE 1

The shampoo composition of the present invention is applied to wet hair in an amount of 3 to 5 ml. Rub wet hair and foam. The foam remained in the head for a short time, for example 1-4 minutes, before rinsing and then rinsing off. If necessary, repeat your hair.

Example 5 (Clinical Experiment)

The following clinical trials were conducted in 64 male 25 years old or older who had never been treated before. Four or more times a week were used, and the same person was subjected to two clinical trials using Comparative Example 3 and Example 4 prepared as the present invention as a control for three weeks.

TABLE 2

Hair loss prevention effect in the treatment and control groups (64 patients)

As shown in the results shown in Table 2, the clinical trials for 64 people with hair loss were found that the hair loss prevention shampoo composition of the present invention has the effect of preventing hair growth or hair loss.

The present invention can be used to prevent hair loss by inhibiting 5-reducing enzymes in the body to prevent DHT from forming during testosterone metabolism, and to improve the blood flow of the scalp to help the metabolism of hair.

Claims (6)

Hair loss prevention shampoo composition comprising the Angelica Root Extract and Burdock Root Extract. The anti-hair loss shampoo composition according to claim 1, wherein the content of the Angelica Root Extract is 0.1 to 10% by weight. The anti-hair loss shampoo composition according to claim 1, wherein the content of said burdock root extract is 0.1 to 10% by weight. The anti-hair loss shampoo composition according to claim 1 or 2, wherein the Angelica Root Extract is prepared by extracting 100 parts by weight of Angelica Root from 500 to 1000 parts by weight of an ethanol aqueous solution having a methanol concentration of 30 to 100% by weight. The anti-hair loss shampoo composition according to claim 1 or 3, wherein the burdock root extract is prepared by extracting 100 parts by weight of burdock root with 500 to 1000 parts by weight of an aqueous ethanol solution having a methanol concentration of 30 to 100% by weight. The anti-hair loss composition according to any one of claims 1 to 3, wherein the formulation of the composition is a shampoo, rinse, lotion, cream, soap, emulsion, essence, or spray.