JP5719519B2 - Hair or scalp cosmetic composition - Google Patents
Hair or scalp cosmetic composition Download PDFInfo
- Publication number
- JP5719519B2 JP5719519B2 JP2010046157A JP2010046157A JP5719519B2 JP 5719519 B2 JP5719519 B2 JP 5719519B2 JP 2010046157 A JP2010046157 A JP 2010046157A JP 2010046157 A JP2010046157 A JP 2010046157A JP 5719519 B2 JP5719519 B2 JP 5719519B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- weight
- present
- effect
- scalp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Cosmetics (AREA)
Description
本発明は、脱毛防止及び毛髪成長促進効果のための毛髪又は頭皮状態改善用の組成物に関し、より詳細には、i)亜鉛ピリチオンと、ii)パンテノールと、iii)サリチル酸、ニコチンアマイド、及び柏子仁抽出物からなる群から選ばれた1種以上とを有効性分として含有し、脱毛防止及び毛髪成長促進効果を有する毛髪又は頭皮化粧料組成物に関する。 The present invention relates to a composition for improving hair or scalp conditions for preventing hair loss and promoting hair growth, and more particularly, i) zinc pyrithione, ii) panthenol, iii) salicylic acid, nicotine amide, and The present invention relates to a hair or scalp cosmetic composition containing one or more selected from the group consisting of coconut extract as an effective component and having hair loss prevention and hair growth promoting effects.
美を重視する現代社会において、脱毛現象は美容の側面で大きな問題になっている。脱毛を誘発する要因は、遺伝、男性ホルモン、老化、ストレス、栄養不足、及びその他の病理的要因等様々である。そのうち、男性ホルモンによる脱毛現象や遺伝的要因による脱毛現象は医学的に多くの研究が進められており、その治療法においても、男性ホルモンであるジハイドロテストステロンの形成に関与する5-α還元酵素を抑制する薬物が開発されているが、その代表的なものとして米国のFDAが承認したフィナステライド(Finasteride,Prppecia;MSD)が知られている。 In modern society, where beauty is important, hair loss is a major problem in terms of beauty. Factors that induce hair loss are various such as heredity, male hormones, aging, stress, nutritional deficiencies, and other pathological factors. Among them, hair loss phenomenon caused by androgen and genetic factors has been extensively studied, and 5-α reductase is involved in the formation of the male hormone dihydrotestosterone. A typical example of such drugs is finasteride (Prppecia; MSD) approved by the US FDA.
一方、ストレスや栄養不足等は、末梢血流障害を起こし、毛髪を合成する毛嚢の機能低下を招くため、脱毛を進行させることが知られている。その解決策として、末梢血液循環を促進し、毛嚢の機能を強化するための脱毛防止薬品が開発されているが、米国のFDAで承認した外用ミノキシジルは、カリウム通路の開放による血管拡張効果によって脱毛防止効果を有すると分析されている。ミノキシジルは、休止期の毛嚢を成長期へ誘導して成長期を維持させる活性が報告されている(非特許文献1)。ミノキシジルのように、多くの脱毛防止薬物の場合、臨床的には明らかな効果をみせるが、そのメカニズムが明確に特定できない場合が多い。特許文献1には、シャクヤク(peony root)、柏子仁、ツルドクダミ(Polygonum multiflorum)及び緑茶等の植物抽出物を含有する脱毛防止及び毛髪成長促進用の組成物が開示されており、特許文献2には、水溶性ビタミンB群及びピリミジンオキサイドを含有し、毛嚢血流拡大による毛髪成長促進用の組成物が開示されている。 On the other hand, stress and nutritional deficiencies cause peripheral blood flow disturbance and cause a decrease in the function of the hair follicle that synthesizes hair. As a solution, anti-hair loss medicines have been developed to promote peripheral blood circulation and enhance the function of hair follicles. It has been analyzed to have a hair loss prevention effect. Minoxidil has been reported to have an activity that induces the resting hair follicle to the growth phase to maintain the growth phase (Non-patent Document 1). Many anti-hair loss drugs, such as minoxidil, have a clinically clear effect, but the mechanism is often unclear. Patent Document 1 discloses a composition for preventing hair loss and promoting hair growth, which contains plant extracts such as peony root, coconut, polygonum multiflorum, and green tea. Discloses a composition for promoting hair growth by expanding hair follicle blood flow, which contains a water-soluble vitamin B group and pyrimidine oxide.
一方、最近では、発毛促進の次元より日常的な管理次元で脱毛防止を要望する女性や若い層の需要が急増しており、このような流れに合わせて、毎日使う洗浄目的のシャンプー組成物に脱毛防止有効性分を含有させて脱毛防止の効果を与えるという傾向が現れている。特許文献3には、益母草(Leonurus sibiricus)の種子、甘松香、ハマカンギク(Chrysanthemum indicum)、桃仁(persicae semen)、山茱萸、兎糸子(lodder fruit)、五味子、オケラの根、松葉、及びトウキ等の数種の漢方材料の混合抽出液を含有する脱毛防止及び発毛促進組成物が開示されており、特許文献4には、トウキの根とゴボウの根のエタノール抽出物を含有することによって、トウキの根のβ-シトステロール成分による5-α還元酵素の抑制効果と、ゴボウの根のイヌリン成分による血流改善効果と、で脱毛防止効果を有する脱毛防止シャンプー組成物が開示されており、特許文献5には、イチョウの葉から抽出したギンコライドA(ginkgolide A)、ギンコライドB、及びビロバライド(bilobalide)を含有し、ふけ防止効果とともに脱毛防止効果を有するシャンプー組成物が開示されており、特許文献6には、紅参の粗サポニン、甘草、ビオチン、コッパーペプチド(Copper Peptide)、及びサイトカイン(cytokine)を含むナノリポソーム粒子を含有する脱毛防止及び発毛促進効果の頭皮化粧料組成物が開示されており、特許文献7には、金と銀を溶かした金銀物に各種の天然漢方素材を入れて沸かして抽出した抽出液をシャンプー組成物に混合した、脱毛防止及び養毛効果を有するシャンプーの製造方法が開示されている。 On the other hand, recently, there has been a rapid increase in demand for women and young people who want to prevent hair loss in the daily management dimension rather than the dimension of promoting hair growth. There is a tendency for hair loss prevention effectiveness to be incorporated into the hair removal prevention effect. Patent Document 3 includes the seeds of beneficial mother grass (Leonurus sibiricus), sweet pine aroma, Chrysanthemum indicum, persicae semen, yam, lodder fruit, gomiko, okera root, pine needles, and toki. A hair loss prevention and hair growth promoting composition containing a mixed extract of several kinds of Chinese medicine materials is disclosed, and Patent Document 4 discloses that an ethanol extract of touki root and burdock root contains An anti-hair loss shampoo composition having an anti-hair loss effect is disclosed in terms of the inhibitory effect of 5-α reductase by the β-sitosterol component of roots and the blood flow improvement effect by the inulin component of burdock roots, and patent literature 5. Shampoo composition containing ginkgolide A (ginkgolide A), ginkgolide B and bilobalide extracted from ginkgo leaves and having anti-dandruff and anti-hair loss effects Patent Document 6 discloses the effect of preventing hair loss and promoting hair growth containing nanoliposome particles containing crude red ginseng crude saponin, licorice, biotin, copper peptide (Copper Peptide), and cytokine (cytokine). A scalp cosmetic composition is disclosed, and Patent Document 7 describes a method for preventing hair loss, in which various extracts of natural Chinese medicines are boiled into gold and silver products in which gold and silver are dissolved and extracted by mixing with the shampoo composition. And the manufacturing method of the shampoo which has a hair nourishing effect is disclosed.
本発明者は、シャンプー使用のように日常的な管理次元で、便利に脱毛防止及び毛髪成長促進効果を提供する組成物を開発しようと工夫した結果、i)亜鉛ピリチオンと、ii)パンテノールと、iii)サリチル酸、ニコチンアマイド、及び柏子仁抽出物からなる群から選ばれた1種以上とを有効性分として含有することによって、成長期の毛髪周期を長く維持させ、脱毛防止や毛髪成長促進効果を与えられることを発見し、本発明を完成した。 The present inventor has devised to develop a composition that provides an effect of preventing hair loss and promoting hair growth on a daily management dimension such as shampoo use. As a result, i) zinc pyrithione, ii) panthenol and Iii) By containing at least one selected from the group consisting of salicylic acid, nicotine amide, and coconut extract as an active ingredient, the hair cycle in the growing period can be maintained for a long period of time to prevent hair loss and promote hair growth The present invention was completed by discovering that an effect can be given.
従って、本発明の目的は、休止期から成長期の毛髪周期への誘導を促進し、成長期の毛髪周期を長く維持させることによって、脱毛防止及び毛髪成長促進効果を有する毛髪又は頭皮化粧料組成物を提供することにある。 Accordingly, an object of the present invention is to provide a hair or scalp cosmetic composition having an effect of preventing hair loss and promoting hair growth by promoting induction from the rest period to the hair cycle in the growth period and maintaining the hair cycle in the growth period for a long time. To provide things.
上記目的を達成するために、本発明では、亜鉛ピリチオン0.01〜2.0重量%と、パンテノール0.01〜2.0重量%と、サリチル酸0.01〜2.0重量%とを有効性分として含有する脱毛防止及び毛髪成長促進効果を有する毛髪又は頭皮化粧料組成物を提供する。 In order to achieve the above object, in the present invention, 0.01 to 2.0% by weight of zinc pyrithione, 0.01 to 2.0% by weight of panthenol, and 0.01 to 2.0% by weight of salicylic acid are included. Provided is a hair or scalp cosmetic composition having an effect of preventing hair loss and promoting hair growth.
本発明による毛髪又は頭皮化粧料組成物は、i)亜鉛ピリチオンと、ii)パンテノールと、iii)サリチル酸、ニコチンアマイド、及び柏子仁抽出物からなる群から選ばれた1種以上とを有効性分として含有することによって、休止期から成長期の毛髪周期への誘導を促進し、成長期の毛髪周期を長く維持させることで、頭皮の脱毛現象を減少させ、毛髪成長を促進する。 The hair or scalp cosmetic composition according to the present invention is effective for i) zinc pyrithione, ii) panthenol, and iii) one or more selected from the group consisting of salicylic acid, nicotine amide, and coconut extract. By containing as a fraction, the induction from the rest period to the hair cycle of the growth phase is promoted, and the hair cycle of the growth phase is maintained for a long time, thereby reducing the hair loss phenomenon of the scalp and promoting hair growth.
以下、本発明をより詳細に説明する。
本発明は、i)亜鉛ピリチオンと、ii)パンテノールと、iii)サリチル酸、ニコチンアマイド、及び柏子仁抽出物からなる群から選ばれた1種以上と、を有効性分として含有する脱毛防止及び毛髪成長促進効果を有する毛髪又は頭皮化粧料組成物に関する。
The present invention will be described in detail below.
The present invention relates to hair loss prevention comprising, as an active ingredient, i) zinc pyrithione, ii) panthenol, and iii) one or more selected from the group consisting of salicylic acid, nicotine amide, and coconut extract. The present invention relates to a hair or scalp cosmetic composition having an effect of promoting hair growth.
本発明で使用する亜鉛ピリチオン(Zinc pyrithione)は、抗菌剤の一種であって、ふけ菌の生長を抑制する抗真菌効果を有する成分であり、下記化学式1で表される。 Zinc pyrithione used in the present invention is a kind of antibacterial agent and is an ingredient having an antifungal effect that suppresses the growth of dandruff, and is represented by the following chemical formula 1.
本発明では、脱毛防止及び毛髪成長促進効果を目的に、亜鉛ピリチオンを組成物の総重量に対して0.01〜2.0重量%含有することが好ましく、亜鉛ピリチオンの含量が0.01重量%未満の場合には効能・効果が微弱であり、2.0重量%を超過する場合には剤形安定化に問題が生じる。 In the present invention, for the purpose of preventing hair loss and promoting hair growth, it is preferable to contain 0.01 to 2.0% by weight of zinc pyrithione with respect to the total weight of the composition, and the content of zinc pyrithione is 0.01% by weight. If it is less than%, the efficacy / effect is weak, and if it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.
本発明で用いるパンテノールは、d-パンテノールと、dl-パンテノール両方とも使用可能であり、下記化学式2で表される。
As panthenol used in the present invention, both d-pantenol and dl-pantenol can be used, and are represented by the following
パンテノールは、パントテン酸(pantothenic acid)の別称であって、体内に吸収された後ビタミンに転換されるプロビタミンB5を指す。化粧品では、主に湿潤剤、軟化剤、及び保湿剤の用途で使用され、炎症及びかゆみを防止し、毛髪をやわらかくし、毛髪の強度を増進させるために使用する。 Panthenol is another name for pantothenic acid and refers to provitamin B5 that is absorbed into the body and then converted to vitamins. In cosmetics, it is mainly used for wetting, softening and moisturizing applications to prevent inflammation and itching, soften hair and enhance hair strength.
本発明では、脱毛防止及び毛髪成長促進効果を目的に、パンテノールを組成物の総重量に対して0.01〜2.0重量%含有することが好ましい。パンテノールの含量が0.01重量%未満の場合には効能・効果が微弱であり、2.0重量%を超過する場合には剤形安定化に問題が生じる。 In the present invention, for the purpose of preventing hair loss and promoting hair growth, pantenol is preferably contained in an amount of 0.01 to 2.0% by weight based on the total weight of the composition. When the panthenol content is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.
本発明で用いるサリチル酸は下記化学式3で表される。 Salicylic acid used in the present invention is represented by the following chemical formula 3.
サリチル酸は、以前から皮膚に関わる様々な疾患に、広範囲に用いられている薬品であって、にきび、ふけ、白斑症、角質、いぼ、及び魚の目等の治療に用いられる。また、サリチル酸は、抗炎作用を有しており、解熱・鎮痛剤であるアスピリン(アセチルサリチル酸)の原料としても用いられている。 Salicylic acid is a drug that has been used extensively for various diseases related to the skin, and is used for the treatment of acne, dandruff, vitiligo, keratin, warts, fish eyes, and the like. Salicylic acid has anti-inflammatory activity and is also used as a raw material for aspirin (acetylsalicylic acid) which is an antipyretic / analgesic agent.
本発明では、脱毛防止及び毛髪成長促進効果を目的に、サリチル酸を組成物の総重量に対して0.01〜2.0重量%含有することが好ましい。サリチル酸の含量が0.01重量%未満の場合には効能・効果が微弱であり、2.0重量%を超過する場合には剤形安定化に問題が生じる。 In the present invention, for the purpose of preventing hair loss and promoting hair growth, it is preferable to contain 0.01 to 2.0% by weight of salicylic acid with respect to the total weight of the composition. When the salicylic acid content is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.
本発明で使用するニコチンアマイドは下記化学式4で表される。 Nicotine amide used in the present invention is represented by the following chemical formula 4.
ニコチンアマイドは、ナイアシンアマイドとも呼ばれ、ビタミンB3をいう。ニコチンアマイドは、水溶性ビタミンであって、生体内で蛋白質代謝に関わる酵素反応の補助酵素として作用する。また、血管を拡張させる能力があり、末梢血流の拡大を目的に使用されることもある。 Nicotine amide is also called niacin amide and refers to vitamin B3. Nicotine amide is a water-soluble vitamin that acts as a coenzyme for enzyme reactions involved in protein metabolism in vivo. It also has the ability to dilate blood vessels and may be used for the purpose of expanding peripheral blood flow.
本発明では、脱毛防止及び毛髪成長促進効果を目的に、ニコチンアマイドを組成物の総重量に対して0.01〜2.0重量%含有することが好ましい。ニコチンアマイドの含量が0.01重量%未満の場合には効能・効果が微弱であり、2.0重量%を超過する場合には剤形安定化に問題が生じる。 In the present invention, it is preferable to contain 0.01 to 2.0% by weight of nicotine amide with respect to the total weight of the composition for the purpose of preventing hair loss and promoting hair growth. When the content of nicotine amide is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.
柏子仁は、コノテカシワ〔Thuja orientalis (occidentalis)(ヒノキ科) Curpressaceae〕の種子であって、卵円形、長い楕円形、又は長い円柱型であり、長さ3〜5mm、直径2〜3mmである。柏子仁は、養心安神、潤腸通便の効能がある(『東洋学概論』)。多量の油脂(fatty oil)が含まれていると知られている。『東医宝鑑』の毛髪編の三聖膏処方には、附子(aconite tuber)、蔓荊子、及び柏子仁から構成され、その効能は、抜けた口ひげや髪の毛等が再び生えてくるようにすると知られているが、その処方は、附子、蔓荊子、及び柏子仁を各20gずつ粉にして、骨の黒い鶏の油(鶏脂)に入れて、よく混ぜて乾燥させた後、器に入れて蓋を閉め、百日間放置した後、髪の毛の抜けた部分に3〜5日間ぬると新しい髪の毛が生えてくる(『東医宝鑑』-毛髪編、「三聖膏」(南山堂))。また、柏子仁は、5α-還元酵素(5α-reductase)阻害活性も表し、2種類の動物モデルでその育毛活性が高く現れたため、アンドロジェン変換を調節して脱毛に有用な物質として使用することができる〔Journal of Dermatological Science(2003)31, 91-98〕。 Zushijin is a seed of Thuja orientalis (occidentalis) (Curchinaceae) Curpressaceae, which is oval, long oval, or long cylindrical, 3-5 mm in length, and 2-3 mm in diameter. Yasuko Jin has the effect of Yasshin Anjin and Jun-in Expressway ("Introduction to Oriental Studies"). It is known to contain a large amount of fatty oil. The three plasters of the hair knitting of “Eastern Medical Treasure Book” are composed of aconite tuber, vine, and lion bean, and its effect is to regain the lost mustache and hair etc. However, it is known that the prescription is made by adding 20 g each of the eggplant, vine, and eggplant, putting them in black bone chicken oil (chicken fat), mixing well and drying, Put it in a container, close the lid, leave it for 100 days, and then apply it to the part where the hair has been removed for 3 to 5 days, and new hair will grow ("Eastern Medical Treasure Book"-Hair Edition, "San Seigo" (Nanzan-do) )). In addition, Zushijin also exhibits 5α-reductase inhibitory activity, and its hair growth activity was high in two animal models. Therefore, it should be used as a substance useful for hair removal by regulating androgen conversion. [Journal of Dermatological Science (2003) 31, 91-98].
本発明で使用する柏子仁抽出物は、コノテカシワの種子から、当業界でよく知られている通常の方法で抽出したものであって、後述の方法で抽出することができるが、これに限定されない。柏子仁を2倍容量の95%エタノールで抽出し、ろ過、濃縮した後、5倍容量の水と5倍容量のエチルアセテートを入れて振とうし、層を分離する。エチルアセテート層の水分を硫酸マグネシウムを用いて除去し、ろ過、濃縮することによって柏子仁抽出物を得る。 The coconut extract used in the present invention is extracted from Konotekashi seeds by an ordinary method well known in the art, and can be extracted by the method described below, but is not limited thereto. . Isogojin is extracted with 2 volumes of 95% ethanol, filtered and concentrated, and then shaken with 5 volumes of water and 5 volumes of ethyl acetate, and the layers are separated. The water of the ethyl acetate layer is removed using magnesium sulfate, filtered and concentrated to obtain a coconut extract.
本発明では、脱毛防止及び毛髪成長促進効果を目的に、柏子仁抽出物を組成物の総重量に対して0.01〜2.0重量%含有することが好ましい。柏子仁抽出物の含量が、0.01重量%未満の場合には効能・効果が微弱であり、2.0重量%を超過する場合には剤形安定化に問題が生じる。 In the present invention, for the purpose of preventing hair loss and promoting hair growth, the coconut extract is preferably contained in an amount of 0.01 to 2.0% by weight based on the total weight of the composition. When the coconut extract content is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.
本発明による毛髪又は頭皮化粧料組成物は、前記有効性分を単独又は2種以上混合して使用することができ、特に、有効性分を3種以上混合して使用する場合、脱毛防止及び毛髪成長促進効果がより向上した。 The hair or scalp cosmetic composition according to the present invention can be used alone or in combination of two or more of the above-mentioned active ingredients. The effect of promoting hair growth was further improved.
本発明の一実施例によると、本発明による毛髪又は頭皮化粧料組成物は、有効性分として亜鉛ピリチオン液、パンテノール、及びサリチル酸を含有するか、又は亜鉛ピリチオン液、パンテノール、ニコチンアマイド、及び柏子仁抽出物を含有することができる。 According to one embodiment of the present invention, the hair or scalp cosmetic composition according to the present invention contains zinc pyrithione liquid, panthenol and salicylic acid as an active ingredient, or zinc pyrithione liquid, panthenol, nicotine amide, And coconut extract.
本発明の一実施例によると、本発明による毛髪又は頭皮化粧料組成物は、当業界で通常使用するアニオン界面活性剤、カチオンポリマー、及びコンディショナー成分をさらに含むことができる。 According to one embodiment of the present invention, the hair or scalp cosmetic composition according to the present invention may further comprise an anionic surfactant, a cationic polymer, and a conditioner component that are commonly used in the art.
本発明で使用するアニオン界面活性剤には、アルキルサルフェート、エトキシル化アルキルサルフェート、アルキルエトキシカルボキシレート、アルキルグリセリルエーテルスルホネート、エトキシエーテルスルホネート、メチルアシルタウレート、アルキルスルホサクシネート、アルキルエトキシスルホサクシネート、アルファ-スルホネート化脂肪酸、これらの塩及び/又はこれらのエステル、アルキルホスフェートエステル、エトキシル化アルキルホスフェートエステル、直鎖アルキルベンゼンスルホネート、パラフィンスルホネート、アルファオレフィンスルホネート、アルキルアルコキシサルフェート、及びこれらの混合物を挙げられるが、これに限定されない。前記界面活性剤のアルキル及び/又はアシル鎖の長さはC12-18、好ましくはC12-14である。C12未満であれば界面活性力が落ちて使用できなくなり、C18超過であれば起泡力が低くなり使用しにくいためである。前記アニオン界面活性剤の含量は、組成物の総重量に対して1〜50重量%、好ましくは5〜20重量%である。アニオン界面活性剤の含量が、1重量%未満の場合には、期待される洗浄力を発揮することができず、50重量%を超過する場合には、過度な洗浄力とともに人体に刺激を与えるため好ましくない。 Anionic surfactants used in the present invention include alkyl sulfates, ethoxylated alkyl sulfates, alkyl ethoxy carboxylates, alkyl glyceryl ether sulfonates, ethoxy ether sulfonates, methyl acyl taurates, alkyl sulfosuccinates, alkyl ethoxy sulfosuccinates, Alpha-sulfonated fatty acids, their salts and / or their esters, alkyl phosphate esters, ethoxylated alkyl phosphate esters, linear alkyl benzene sulfonates, paraffin sulfonates, alpha olefin sulfonates, alkyl alkoxy sulfates, and mixtures thereof. However, the present invention is not limited to this. The alkyl and / or acyl chain length of the surfactant is C 12-18 , preferably C 12-14 . Surfactants force fell unusable if it is less than C 12, foaming power if C 18 excess is because it is difficult to use low. The content of the anionic surfactant is 1 to 50% by weight, preferably 5 to 20% by weight, based on the total weight of the composition. When the content of the anionic surfactant is less than 1% by weight, the expected detergency cannot be exhibited, and when it exceeds 50% by weight, the human body is stimulated with excessive detergency. Therefore, it is not preferable.
本発明で使用するカチオンポリマーには、ヒドロキシエチルセルロースのポリマリッククォータナリーアンモニウム塩類、及びグアーヒドロキシプロピルトリアンモニウムクロライド類等を挙げられるが、これに限定されない。カチオンポリマーは、ヘアーコンディショナーの効果、髪の毛の表面をやわらかくする効果、起泡力を高めて泡に弾力を与える効果を有する。前記アニオンポリマーの含量は、組成物の総重量に対して0.1〜1.0重量%、好ましくは0.1〜0.5重量%である。カチオンポリマーの含量が、0.1重量%未満の場合には前記効果が期待できず、1.0重量%を超過する場合には粘度をコントロールしにくくなり、毛髪に過度に付着するため、使用感が顕著に減少する。 Examples of the cationic polymer used in the present invention include, but are not limited to, polymeric quaternary ammonium salts of hydroxyethyl cellulose and guar hydroxypropyltriammonium chlorides. The cationic polymer has the effect of a hair conditioner, the effect of softening the surface of the hair, and the effect of increasing the foaming power and giving the foam elasticity. The content of the anionic polymer is 0.1 to 1.0% by weight, preferably 0.1 to 0.5% by weight, based on the total weight of the composition. When the content of the cationic polymer is less than 0.1% by weight, the above effect cannot be expected, and when it exceeds 1.0% by weight, it becomes difficult to control the viscosity, and it adheres excessively to the hair. The feeling is significantly reduced.
本発明で使用するコンディショナー成分としては、シクロメチコン、ジメチコン(ジメチルポリシロキサン)、ジメチコンコポリオール、アルキルジメチコンコポリオール、シリコーンエステル、フルオロジメチコン、アルキルジメチコン、ジメチコンコポリオールアミン、カルボキシシリコーン、シリコーンホスフェートエステル、シリコーンレジン、シリコーンホスホリピッド、アモジメチコン、アミノプロピルジメチコン、及びシリコーンクァッツ(silicone quats)を含むシリコーンを挙げられるが、これに限定されない。前記コンディショナー成分の含量は、組成物の総重量に対して0.01〜5.0重量%、好ましくは1.3〜3.0重量%である。前記コンディショナー成分の含量が、0.01重量%未満の場合にはコンディショナーの効果が期待できず、5.0重量%を超過する場合には剤形の不安定化による品質低下のおそれがあるためである。 Conditioner components used in the present invention include cyclomethicone, dimethicone (dimethylpolysiloxane), dimethicone copolyol, alkyl dimethicone copolyol, silicone ester, fluorodimethicone, alkyl dimethicone, dimethicone copolyolamine, carboxysilicone, silicone phosphate ester, Examples include, but are not limited to, silicone resins, silicone phospholipids, amodimethicone, aminopropyl dimethicone, and silicone quats. The content of the conditioner component is 0.01 to 5.0% by weight, preferably 1.3 to 3.0% by weight, based on the total weight of the composition. If the content of the conditioner component is less than 0.01% by weight, the effect of the conditioner cannot be expected, and if it exceeds 5.0% by weight, the dosage form may become unstable due to destabilization. It is.
また、本発明の一実施例によると、本発明による毛髪又は頭皮化粧料組成物は、安定度を維持する範囲内で、当業界で通常使用する色素、防腐剤、金属イオン封鎖剤、及び香料等をさらに含むことができる。 In addition, according to one embodiment of the present invention, the hair or scalp cosmetic composition according to the present invention contains pigments, preservatives, sequestering agents, and fragrances that are commonly used in the industry within a range that maintains stability. Etc. can be further included.
本発明の一実施例による毛髪又は頭皮化粧料組成物は、毛髪洗浄剤組成物であり、ヘアーシャンプー、ヘアーリンス、ヘアーコンディショナー、ヘアートリートメント、ヘアトニック、スカルプトリートメント、ヘアーローション、ヘアークリーム、毛髪栄養化粧水、又は一般軟膏剤等に剤形化することができる。
以下、毛髪又は頭皮化粧料組成物に関する本発明の好ましい実施例及び比較例に関し、より具体的に説明する。後述する実施例は、本発明の好ましい一実施例であり、本発明を限定するものではない。
The hair or scalp cosmetic composition according to one embodiment of the present invention is a hair cleansing composition, and is a hair shampoo, hair rinse, hair conditioner, hair treatment, hair tonic, scalp treatment, hair lotion, hair cream, hair nutrition. It can be formulated into a lotion or general ointment.
Hereinafter, it demonstrates more concretely about the preferable Example and comparative example of this invention regarding hair or scalp cosmetics composition. The embodiment described below is a preferred embodiment of the present invention and does not limit the present invention.
[参考例1] 柏子仁抽出物の製造
乾燥させたコノテカシワの種子1kgに95%エタノール水溶液2リットルを入れ、3回還流抽出してろ過、濃縮した後、水とエチルアセテートを各々5リットルずつ入れ、振とうして層を分離した後、エチルアセテート層の水分を硫酸マグネシウムを用いて除去し、ろ過、濃縮して柏子仁抽出物を得た。
[Reference Example 1] Manufacture of coconut extract Extract 1 kg of dried Konotekashi seeds was charged with 2 liters of 95% ethanol aqueous solution, extracted by refluxing three times, filtered and concentrated, and then 5 liters each of water and ethyl acetate were added. After separating the layers by shaking, the water in the ethyl acetate layer was removed using magnesium sulfate, filtered and concentrated to obtain a coconut extract.
[実施例1、比較例1及び参照例1]
下記の表1に記載の組成により各成分を混合し、実施例1、比較例1及び参照例1の組成物を製造した(単位:重量%)。亜鉛ピリチオン液は、韓国食品医薬品安定庁の告示規格の48%亜鉛ピリチオン分散液〔API CORPORATION (2-3-4, NIHONBASHI, CHUO-KU, TOKYO, 103-0027, JAPAN)〕を実施例1、比較例1及び参照例1の剤形に直接分散して使用し、パンテノールは、米国薬典規格〔DSM Nutritional Products LTD. (Darly Ayrshire Scotland UK KA25JJ)〕を常温で水と界面活性剤の混合液に可溶化して使用した。一方、サリチル酸は、大韓薬典規格〔Rhodia Organique (Rue Gaston Monmousseau 38556 Roussillon, France)〕野原料を65℃の加温工程で水と界面活性剤の混合液に可溶化して使用した。ニコチンアマイドは、英国薬典規格〔Amsal Chem. Pvt. Ltd. (A-1/401/402/403, G.I.D.C., Ankleshwar, Gujarat State, India.)〕のものを常温で水と界面活性剤の混合液に可溶化して使用し、参考例1で製造した柏子仁抽出物は公定書以外の別途規格〔株式会社韓仏化農(京畿道 龍仁市 駒城邑上下里505-1)〕のものを剤形に直接添加する方式を使用した。
[ Example 1, Comparative Example 1 and Reference Example 1 ]
Each component was mixed according to the composition described in Table 1 below to produce the compositions of Example 1, Comparative Example 1 and Reference Example 1 (unit: wt%). The zinc pyrithione solution is 48% zinc pyrithione dispersion (API CORPORATION (2-3-4, NIHONBASHI, CHUO-KU, TOKYO, 103-0027, JAPAN)) of the notification standard of the Korean Food and Drug Stabilization Agency, Example 1. Directly dispersed in the dosage forms of Comparative Example 1 and Reference Example 1 , Pantenol is a mixture of water and a surfactant at room temperature according to the US Pharmaceutical Standard (DSM Nutritional Products LTD. (Darly Ayrshire Scotland UK KA25JJ)). It was used after being solubilized in the liquid. On the other hand, salicylic acid was used by solubilizing a Korean medicine standard [Rhodia Organique (Rue Gaston Monmousseau 38556 Roussillon, France)] in a mixture of water and a surfactant in a heating process at 65 ° C. Nicotine amide is a mixture of water and a surfactant at room temperature in accordance with British pharmaceutical standards (Amsal Chem. Pvt. Ltd. (A-1 / 401/402/403, GIDC, Ankleshwar, Gujarat State, India.)). The coconut extract extracted in Example 1 was solubilized in the liquid and manufactured according to a separate standard other than the official document [Korean-French Agriculture Co., Ltd. Was used directly in the dosage form.
[試験例1] 脱毛防止効果試験
初期脱毛現象のある被検者30名を対象に、脱毛防止効果に関する実験を16週間行った。前記実施例1、比較例1及び参照例1の組成物を1日1回ずつ16週間使用した後、髪を洗った後、脱落毛を収集して個数を数え、その結果を下記の表2及び図1に表した。
[Test Example 1] Hair loss prevention effect test An experiment on hair loss prevention effect was conducted for 30 subjects with initial hair loss phenomenon for 16 weeks. After the compositions of Example 1, Comparative Example 1 and Reference Example 1 were used once a day for 16 weeks, the hair was washed, the shed hairs were collected and counted, and the results are shown in Table 2 below. And shown in FIG.
前記表2と図1から分かるように、本発明による実施例1及び参照例1の組成物で処理する場合、比較例1に比べて脱落毛の個数が顕著に減少した。 As can be seen from Table 2 and FIG. 1, when treated with the compositions of Example 1 and Reference Example 1 according to the present invention, the number of shed hairs was significantly reduced as compared with Comparative Example 1.
[試験例2] 毛髪成長効果試験
毛髪成長効果をテストするために、生後7週のマウス(C57BL/6)の背中部位の毛を除去し、背中部位の皮膚が清潔なマウスを選択して、物質群ごとに10匹ずつを選定し、毎日前記実施例1、比較例1及び参照例1の組成物をそれぞれのマウスグループ個体に150μlずつ21日間塗布した後、洗浄した。23日後に、新しく生えてきた毛の重量を測って比較し、その結果を下記の表3及び図2に表した。
[Test Example 2] Hair growth effect test In order to test the hair growth effect, hair on the back part of a 7 week old mouse (C57BL / 6) was removed, and a mouse with clean skin on the back part was selected. Ten mice were selected for each substance group, and 150 μl of the composition of Example 1, Comparative Example 1 and Reference Example 1 were applied to each individual mouse group for 21 days, and then washed. After 23 days, the newly grown hairs were weighed and compared, and the results are shown in Table 3 and FIG.
前記表3及び図2から分かるように、本発明による実施例1及び参照例1の組成物が休止期の毛髪周期のマウスに作用し、成長期の毛髪周期への履行を促進させることによって、比較例1の組成物より優れた毛髪成長促進効果を有することが確認された。
As can be seen from Table 3 and FIG. 2 above, the composition of Example 1 and Reference Example 1 according to the present invention acts on mice in the resting hair cycle, and promotes fulfillment to the growing hair cycle, It was confirmed that the hair growth promoting effect was superior to the composition of Comparative Example 1.
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