JP5719519B2 - Hair or scalp cosmetic composition - Google Patents

Description

  The present invention relates to a composition for improving hair or scalp conditions for preventing hair loss and promoting hair growth, and more particularly, i) zinc pyrithione, ii) panthenol, iii) salicylic acid, nicotine amide, and The present invention relates to a hair or scalp cosmetic composition containing one or more selected from the group consisting of coconut extract as an effective component and having hair loss prevention and hair growth promoting effects.

  In modern society, where beauty is important, hair loss is a major problem in terms of beauty. Factors that induce hair loss are various such as heredity, male hormones, aging, stress, nutritional deficiencies, and other pathological factors. Among them, hair loss phenomenon caused by androgen and genetic factors has been extensively studied, and 5-α reductase is involved in the formation of the male hormone dihydrotestosterone. A typical example of such drugs is finasteride (Prppecia; MSD) approved by the US FDA.

  On the other hand, stress and nutritional deficiencies cause peripheral blood flow disturbance and cause a decrease in the function of the hair follicle that synthesizes hair. As a solution, anti-hair loss medicines have been developed to promote peripheral blood circulation and enhance the function of hair follicles. It has been analyzed to have a hair loss prevention effect. Minoxidil has been reported to have an activity that induces the resting hair follicle to the growth phase to maintain the growth phase (Non-patent Document 1). Many anti-hair loss drugs, such as minoxidil, have a clinically clear effect, but the mechanism is often unclear. Patent Document 1 discloses a composition for preventing hair loss and promoting hair growth, which contains plant extracts such as peony root, coconut, polygonum multiflorum, and green tea. Discloses a composition for promoting hair growth by expanding hair follicle blood flow, which contains a water-soluble vitamin B group and pyrimidine oxide.

  On the other hand, recently, there has been a rapid increase in demand for women and young people who want to prevent hair loss in the daily management dimension rather than the dimension of promoting hair growth. There is a tendency for hair loss prevention effectiveness to be incorporated into the hair removal prevention effect. Patent Document 3 includes the seeds of beneficial mother grass (Leonurus sibiricus), sweet pine aroma, Chrysanthemum indicum, persicae semen, yam, lodder fruit, gomiko, okera root, pine needles, and toki. A hair loss prevention and hair growth promoting composition containing a mixed extract of several kinds of Chinese medicine materials is disclosed, and Patent Document 4 discloses that an ethanol extract of touki root and burdock root contains An anti-hair loss shampoo composition having an anti-hair loss effect is disclosed in terms of the inhibitory effect of 5-α reductase by the β-sitosterol component of roots and the blood flow improvement effect by the inulin component of burdock roots, and patent literature 5. Shampoo composition containing ginkgolide A (ginkgolide A), ginkgolide B and bilobalide extracted from ginkgo leaves and having anti-dandruff and anti-hair loss effects Patent Document 6 discloses the effect of preventing hair loss and promoting hair growth containing nanoliposome particles containing crude red ginseng crude saponin, licorice, biotin, copper peptide (Copper Peptide), and cytokine (cytokine). A scalp cosmetic composition is disclosed, and Patent Document 7 describes a method for preventing hair loss, in which various extracts of natural Chinese medicines are boiled into gold and silver products in which gold and silver are dissolved and extracted by mixing with the shampoo composition. And the manufacturing method of the shampoo which has a hair nourishing effect is disclosed.

Korean Patent No. 10-0,839,588 Korean Patent Publication No. 2007-0,065,950 Korean Patent No. 10-0,581,316 Korean Patent No. 10-0,609,210 Korean Patent No. 10-0,579,710 Korean Patent No. 10-0,763,437 Korean Patent No. 10-0,806,125

British Journal of Dermatology. 2004; 150: 186-194

  The present inventor has devised to develop a composition that provides an effect of preventing hair loss and promoting hair growth on a daily management dimension such as shampoo use. As a result, i) zinc pyrithione, ii) panthenol and Iii) By containing at least one selected from the group consisting of salicylic acid, nicotine amide, and coconut extract as an active ingredient, the hair cycle in the growing period can be maintained for a long period of time to prevent hair loss and promote hair growth The present invention was completed by discovering that an effect can be given.

  Accordingly, an object of the present invention is to provide a hair or scalp cosmetic composition having an effect of preventing hair loss and promoting hair growth by promoting induction from the rest period to the hair cycle in the growth period and maintaining the hair cycle in the growth period for a long time. To provide things.

In order to achieve the above object, in the present invention, 0.01 to 2.0% by weight of zinc pyrithione, 0.01 to 2.0% by weight of panthenol, and 0.01 to 2.0% by weight of salicylic acid are included. Provided is a hair or scalp cosmetic composition having an effect of preventing hair loss and promoting hair growth.

  The hair or scalp cosmetic composition according to the present invention is effective for i) zinc pyrithione, ii) panthenol, and iii) one or more selected from the group consisting of salicylic acid, nicotine amide, and coconut extract. By containing as a fraction, the induction from the rest period to the hair cycle of the growth phase is promoted, and the hair cycle of the growth phase is maintained for a long time, thereby reducing the hair loss phenomenon of the scalp and promoting hair growth.

FIG. 1 is a graph showing the effect of preventing hair loss of the composition according to the present invention. FIG. 2 is a graph showing the effect of promoting hair growth in mice of the composition according to the present invention.

The present invention will be described in detail below.
The present invention relates to hair loss prevention comprising, as an active ingredient, i) zinc pyrithione, ii) panthenol, and iii) one or more selected from the group consisting of salicylic acid, nicotine amide, and coconut extract. The present invention relates to a hair or scalp cosmetic composition having an effect of promoting hair growth.

  Zinc pyrithione used in the present invention is a kind of antibacterial agent and is an ingredient having an antifungal effect that suppresses the growth of dandruff, and is represented by the following chemical formula 1.

現在市販されているふけと頭皮のかゆみを解消するシャンプー、リンス、コンディショナー、クリーム、及びゲル等のほとんどの製品にこの成分が添加されている。

This ingredient is added to most products on the market such as shampoos, rinses, conditioners, creams, and gels that eliminate dandruff and scalp itching.

  In the present invention, for the purpose of preventing hair loss and promoting hair growth, it is preferable to contain 0.01 to 2.0% by weight of zinc pyrithione with respect to the total weight of the composition, and the content of zinc pyrithione is 0.01% by weight. If it is less than%, the efficacy / effect is weak, and if it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.

  As panthenol used in the present invention, both d-pantenol and dl-pantenol can be used, and are represented by the following chemical formula 2.

  Panthenol is another name for pantothenic acid and refers to provitamin B5 that is absorbed into the body and then converted to vitamins. In cosmetics, it is mainly used for wetting, softening and moisturizing applications to prevent inflammation and itching, soften hair and enhance hair strength.

  In the present invention, for the purpose of preventing hair loss and promoting hair growth, pantenol is preferably contained in an amount of 0.01 to 2.0% by weight based on the total weight of the composition. When the panthenol content is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.

  Salicylic acid used in the present invention is represented by the following chemical formula 3.

  Salicylic acid is a drug that has been used extensively for various diseases related to the skin, and is used for the treatment of acne, dandruff, vitiligo, keratin, warts, fish eyes, and the like. Salicylic acid has anti-inflammatory activity and is also used as a raw material for aspirin (acetylsalicylic acid) which is an antipyretic / analgesic agent.

  In the present invention, for the purpose of preventing hair loss and promoting hair growth, it is preferable to contain 0.01 to 2.0% by weight of salicylic acid with respect to the total weight of the composition. When the salicylic acid content is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.

  Nicotine amide used in the present invention is represented by the following chemical formula 4.

  Nicotine amide is also called niacin amide and refers to vitamin B3. Nicotine amide is a water-soluble vitamin that acts as a coenzyme for enzyme reactions involved in protein metabolism in vivo. It also has the ability to dilate blood vessels and may be used for the purpose of expanding peripheral blood flow.

  In the present invention, it is preferable to contain 0.01 to 2.0% by weight of nicotine amide with respect to the total weight of the composition for the purpose of preventing hair loss and promoting hair growth. When the content of nicotine amide is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.

  Zushijin is a seed of Thuja orientalis (occidentalis) (Curchinaceae) Curpressaceae, which is oval, long oval, or long cylindrical, 3-5 mm in length, and 2-3 mm in diameter. Yasuko Jin has the effect of Yasshin Anjin and Jun-in Expressway ("Introduction to Oriental Studies"). It is known to contain a large amount of fatty oil. The three plasters of the hair knitting of “Eastern Medical Treasure Book” are composed of aconite tuber, vine, and lion bean, and its effect is to regain the lost mustache and hair etc. However, it is known that the prescription is made by adding 20 g each of the eggplant, vine, and eggplant, putting them in black bone chicken oil (chicken fat), mixing well and drying, Put it in a container, close the lid, leave it for 100 days, and then apply it to the part where the hair has been removed for 3 to 5 days, and new hair will grow ("Eastern Medical Treasure Book"-Hair Edition, "San Seigo" (Nanzan-do) )). In addition, Zushijin also exhibits 5α-reductase inhibitory activity, and its hair growth activity was high in two animal models. Therefore, it should be used as a substance useful for hair removal by regulating androgen conversion. [Journal of Dermatological Science (2003) 31, 91-98].

  The coconut extract used in the present invention is extracted from Konotekashi seeds by an ordinary method well known in the art, and can be extracted by the method described below, but is not limited thereto. . Isogojin is extracted with 2 volumes of 95% ethanol, filtered and concentrated, and then shaken with 5 volumes of water and 5 volumes of ethyl acetate, and the layers are separated. The water of the ethyl acetate layer is removed using magnesium sulfate, filtered and concentrated to obtain a coconut extract.

  In the present invention, for the purpose of preventing hair loss and promoting hair growth, the coconut extract is preferably contained in an amount of 0.01 to 2.0% by weight based on the total weight of the composition. When the coconut extract content is less than 0.01% by weight, the efficacy / effect is weak, and when it exceeds 2.0% by weight, there is a problem in stabilizing the dosage form.

  The hair or scalp cosmetic composition according to the present invention can be used alone or in combination of two or more of the above-mentioned active ingredients. The effect of promoting hair growth was further improved.

  According to one embodiment of the present invention, the hair or scalp cosmetic composition according to the present invention contains zinc pyrithione liquid, panthenol and salicylic acid as an active ingredient, or zinc pyrithione liquid, panthenol, nicotine amide, And coconut extract.

  According to one embodiment of the present invention, the hair or scalp cosmetic composition according to the present invention may further comprise an anionic surfactant, a cationic polymer, and a conditioner component that are commonly used in the art.

Anionic surfactants used in the present invention include alkyl sulfates, ethoxylated alkyl sulfates, alkyl ethoxy carboxylates, alkyl glyceryl ether sulfonates, ethoxy ether sulfonates, methyl acyl taurates, alkyl sulfosuccinates, alkyl ethoxy sulfosuccinates, Alpha-sulfonated fatty acids, their salts and / or their esters, alkyl phosphate esters, ethoxylated alkyl phosphate esters, linear alkyl benzene sulfonates, paraffin sulfonates, alpha olefin sulfonates, alkyl alkoxy sulfates, and mixtures thereof. However, the present invention is not limited to this. The alkyl and / or acyl chain length of the surfactant is C _12-18 , preferably C _12-14 . Surfactants force fell unusable if it is less than C _12, foaming power if C ₁₈ excess is because it is difficult to use low. The content of the anionic surfactant is 1 to 50% by weight, preferably 5 to 20% by weight, based on the total weight of the composition. When the content of the anionic surfactant is less than 1% by weight, the expected detergency cannot be exhibited, and when it exceeds 50% by weight, the human body is stimulated with excessive detergency. Therefore, it is not preferable.

  Examples of the cationic polymer used in the present invention include, but are not limited to, polymeric quaternary ammonium salts of hydroxyethyl cellulose and guar hydroxypropyltriammonium chlorides. The cationic polymer has the effect of a hair conditioner, the effect of softening the surface of the hair, and the effect of increasing the foaming power and giving the foam elasticity. The content of the anionic polymer is 0.1 to 1.0% by weight, preferably 0.1 to 0.5% by weight, based on the total weight of the composition. When the content of the cationic polymer is less than 0.1% by weight, the above effect cannot be expected, and when it exceeds 1.0% by weight, it becomes difficult to control the viscosity, and it adheres excessively to the hair. The feeling is significantly reduced.

  Conditioner components used in the present invention include cyclomethicone, dimethicone (dimethylpolysiloxane), dimethicone copolyol, alkyl dimethicone copolyol, silicone ester, fluorodimethicone, alkyl dimethicone, dimethicone copolyolamine, carboxysilicone, silicone phosphate ester, Examples include, but are not limited to, silicone resins, silicone phospholipids, amodimethicone, aminopropyl dimethicone, and silicone quats. The content of the conditioner component is 0.01 to 5.0% by weight, preferably 1.3 to 3.0% by weight, based on the total weight of the composition. If the content of the conditioner component is less than 0.01% by weight, the effect of the conditioner cannot be expected, and if it exceeds 5.0% by weight, the dosage form may become unstable due to destabilization. It is.

  In addition, according to one embodiment of the present invention, the hair or scalp cosmetic composition according to the present invention contains pigments, preservatives, sequestering agents, and fragrances that are commonly used in the industry within a range that maintains stability. Etc. can be further included.

The hair or scalp cosmetic composition according to one embodiment of the present invention is a hair cleansing composition, and is a hair shampoo, hair rinse, hair conditioner, hair treatment, hair tonic, scalp treatment, hair lotion, hair cream, hair nutrition. It can be formulated into a lotion or general ointment.
Hereinafter, it demonstrates more concretely about the preferable Example and comparative example of this invention regarding hair or scalp cosmetics composition. The embodiment described below is a preferred embodiment of the present invention and does not limit the present invention.

[Reference Example 1] Manufacture of coconut extract Extract 1 kg of dried Konotekashi seeds was charged with 2 liters of 95% ethanol aqueous solution, extracted by refluxing three times, filtered and concentrated, and then 5 liters each of water and ethyl acetate were added. After separating the layers by shaking, the water in the ethyl acetate layer was removed using magnesium sulfate, filtered and concentrated to obtain a coconut extract.

[ Example 1, Comparative Example 1 and Reference Example 1 ]
Each component was mixed according to the composition described in Table 1 below to produce the compositions of Example 1, Comparative Example 1 and Reference Example 1 (unit: wt%). The zinc pyrithione solution is 48% zinc pyrithione dispersion (API CORPORATION (2-3-4, NIHONBASHI, CHUO-KU, TOKYO, 103-0027, JAPAN)) of the notification standard of the Korean Food and Drug Stabilization Agency, Example 1. Directly dispersed in the dosage forms of Comparative Example 1 and Reference Example 1 , Pantenol is a mixture of water and a surfactant at room temperature according to the US Pharmaceutical Standard (DSM Nutritional Products LTD. (Darly Ayrshire Scotland UK KA25JJ)). It was used after being solubilized in the liquid. On the other hand, salicylic acid was used by solubilizing a Korean medicine standard [Rhodia Organique (Rue Gaston Monmousseau 38556 Roussillon, France)] in a mixture of water and a surfactant in a heating process at 65 ° C. Nicotine amide is a mixture of water and a surfactant at room temperature in accordance with British pharmaceutical standards (Amsal Chem. Pvt. Ltd. (A-1 / 401/402/403, GIDC, Ankleshwar, Gujarat State, India.)). The coconut extract extracted in Example 1 was solubilized in the liquid and manufactured according to a separate standard other than the official document [Korean-French Agriculture Co., Ltd. Was used directly in the dosage form.

[Test Example 1] Hair loss prevention effect test An experiment on hair loss prevention effect was conducted for 30 subjects with initial hair loss phenomenon for 16 weeks. After the compositions of Example 1, Comparative Example 1 and Reference Example 1 were used once a day for 16 weeks, the hair was washed, the shed hairs were collected and counted, and the results are shown in Table 2 below. And shown in FIG.

As can be seen from Table 2 and FIG. 1, when treated with the compositions of Example 1 and Reference Example 1 according to the present invention, the number of shed hairs was significantly reduced as compared with Comparative Example 1.

[Test Example 2] Hair growth effect test In order to test the hair growth effect, hair on the back part of a 7 week old mouse (C57BL / 6) was removed, and a mouse with clean skin on the back part was selected. Ten mice were selected for each substance group, and 150 μl of the composition of Example 1, Comparative Example 1 and Reference Example 1 were applied to each individual mouse group for 21 days, and then washed. After 23 days, the newly grown hairs were weighed and compared, and the results are shown in Table 3 and FIG.

As can be seen from Table 3 and FIG. 2 above, the composition of Example 1 and Reference Example 1 according to the present invention acts on mice in the resting hair cycle, and promotes fulfillment to the growing hair cycle, It was confirmed that the hair growth promoting effect was superior to the composition of Comparative Example 1.

Claims (2)

A hair loss prevention and hair or scalp a cosmetic composition having a hair growth promoting effect, and zinc pyrithione 0.01-2.0 wt%, panthenol 0.01 to 2.0 wt%, salicylic acid 0.01 A hair or scalp cosmetic composition comprising -2.0% by weight as an active ingredient. The composition, hair shampoos, hair rinses, hair conditioners, hair treatments, hair tonic, scalp treatment, hair lotion, hair cream, hair nutrient lotion, or claims, characterized in formulated to be that agent generally ointment Item 2. The hair or scalp cosmetic composition according to Item 1 .

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