JP2007045712A - Scalp and hair cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a scalp and hair cosmetic that exhibits more excellent refreshing feeling by external application to scalp and hair, especially excellent durability of refreshing feeling, improved sense of use and high hair growth effect. <P>SOLUTION: The scalp and hair cosmetic comprises at least one or more kinds selected from (A) one or more kinds of cell activators selected from pantothenic acid and/or its derivative, placental extracts, etc., (B) one or more kinds of blood flow ameliorants selected from carpronium chloride, vitamin E derivative, essence of Swertia japonica, minoxidil, etc., (C) one or more kinds of antiinflammatory agents selected from glycyrrhetic acid and/or its derivative and glycyrrhizic acid and/or its derivative, (D) one or more kinds of germicides selected from isopropylmethylphenol, salicylic acid, hinokitiol, etc., and (E) one or more kinds of topical stimulants selected from benzyl nicotinate and nonylic acid vanillylamide, a polyhydric alcohol, an organic acid and menthol. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a scalp hair cosmetic, and more particularly, to a scalp hair cosmetic having a high level of refreshment and a high hair-growth effect by being externally applied to the scalp hair.

  In general, a refreshing feeling when used in scalp and hair cosmetics is important. For example, a tonic agent is expected to have an effect of making the scalp feel clean by giving a refreshing feeling. Moreover, in the hair restorer, the effect | action which produces the effect actual effect of the hair growth effect is anticipated.

In order to obtain such an action, refreshing ingredients such as menthol and its derivatives, camphor, and eucalyptus oil are used.
However, these conventionally used refreshing ingredients have a narrow threshold of refreshing feeling and irritation, and when such a cooling ingredient is used in a large amount, it leads to a feeling of irritation. It was not an ingredient.

On the other hand, for the purpose of providing an optimum refreshing feeling with little irritation, for example, a refreshing feel composition using monomenthyl glyceryl ether, camphor and menthol (for example, see Patent Document 1) is known. For the purpose of enhancement and improvement in sustainability, for example, a formulation using menthol and a dioxolane-2-acetic acid derivative (see, for example, Patent Document 2) is known.
However, both of the above-mentioned documents 1 and 2 have a problem in that the refreshing feeling is still insufficient and the sustainability of the refreshing feeling is insufficient.

Moreover, there is percutaneous absorption of an active ingredient as an index of the hair growth effect, and surfactants, ester oils, polyhydric alcohols and the like are generally known as percutaneous absorption enhancers. Furthermore, as an example using polyhydric alcohol, for the purpose of promoting percutaneous absorption of a whitening component, for example, an external preparation for skin containing polyethylene glycol (for example, see Patent Document 3), polyhydric alcohol and menthol were used. As an example, for the purpose of percutaneous absorption of caffeine, for example, a formulation containing polyethylene glycol and menthol (for example, see Patent Document 4) is known.
However, the documents 3 and 4 have a problem in that the transdermal absorbability is still insufficient.
JP-A-11-92327 (Claims, Examples, etc.) Kaihei 7-228887 (Claims, Examples, etc.) JP 2001-106621 (Claims, Examples, etc.) JP 10-53527 A (Claims, Examples, etc.)

  The present invention is to solve this problem in view of the above-mentioned problems of the prior art, and exhibits an excellent refreshing feeling when applied externally to the scalp hair. In particular, the refreshing feeling is excellent and the feeling of use is excellent. An object of the present invention is to provide a scalp hair cosmetic having a good and high hair growth effect.

  In order to solve the above-mentioned conventional problems, etc., the present inventor has found that the components of the polyhydric alcohol and the organic acid have the intended action as a result of intensive studies, and complete the present invention. It has come.

That is, the present invention resides in the following (1) to (4).
(1) A scalp hair cosmetic comprising at least one or more selected from the following (A) to (E), a polyhydric alcohol, an organic acid, and menthol.
(A) Pantothenic acid and / or derivative thereof, placenta extract, photosensitizer, biotin, adenine and / or derivative thereof, thymine and / or derivative thereof, guanine and / or derivative thereof, cytosine and / or derivative thereof, uracil and / or Alternatively, a cell activator containing one or more selected from the group consisting of derivatives thereof, astilbine and / or derivatives thereof, and mononitroguaiacol.
(B) A blood flow improving agent containing at least one selected from carpronium chloride, vitamin E derivatives, assembly extract, cephalanthin, nicotinamide, carrot extract, and minoxidil.
(C) The anti-inflammatory agent containing 1 or more types chosen from glycyrrhetic acid and / or its derivative (s), glycyrrhizic acid and / or its derivative (s).
(D) Disinfection containing at least one selected from isopropylmethylphenol, salicylic acid, hinokitiol, benzalkonium chloride, benzethonium chloride, trichlorocarbanilide, zinc pyrithione, 1-hydroxy-2-pyridone compounds or salts thereof, and propolis Agent.
(E) A local stimulant containing one or more selected from benzyl nicotinate and nonyl acid vanillylamide.
(2) The polyhydric alcohol described in (1) is at least one selected from the group consisting of polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene glycol, diethylene glycol, triethylene glycol, pentanediol, isoprene glycol, and hexanediol. Scalp hair cosmetics that are more than seeds.
(3) A scalp hair cosmetic, wherein the organic acid according to (1) is at least one selected from the group consisting of citric acid, succinic acid, malic acid, lactic acid, fumaric acid, tartaric acid, and phytic acid.
(4) A combustible gas selected from butane, propane, isobutane, liquefied petroleum gas, and dimethyl ether and / or a compressed gas selected from nitrogen gas, oxygen gas, carbon dioxide gas, and nitrous oxide gas was used as an aerosol agent. The scalp hair cosmetic according to any one of (1) to (3) above, wherein

  ADVANTAGE OF THE INVENTION According to this invention, the scalp hair cosmetics which show the refreshing feeling excellent by applying to scalp hair externally, are excellent in especially the sustainability of a refreshing feeling, have a favorable feeling of use, and have a high hair growth effect are provided.

Hereinafter, embodiments of the present invention will be described in detail.
The scalp hair cosmetic of the present invention is one or two selected from (A) a cell activator, (B) a blood flow improving agent, (C) an anti-inflammatory agent, (D) a bactericidal agent, and (E) a local stimulant. It contains at least a seed, a polyhydric alcohol, an organic acid, and menthol.

  As the cell activator of the component (A) used in the present invention, pantothenic acid and / or a derivative thereof, placenta extract, photosensitizer, biotin, adenine and / or a derivative thereof, thymine and / or a derivative thereof, guanine and / or a derivative thereof Derivatives, cytosine and / or derivatives thereof, uracil and / or derivatives thereof, derivatives thereof, astilbine and / or derivatives thereof, mononitroguaiacol, etc. are preferred, and among these, pantothenic acid and It is desirable to use / or a derivative thereof, adenine, a derivative of guanine, astilbine and / or a derivative thereof, and more preferably, use of pantothenyl alcohol, pantothenyl ethyl ether, and adenosine.

As the blood flow improving agent of component (B) used in the present invention, carpronium chloride, vitamin E derivative, assembly extract, cephalanthin, nicotinamide, carrot extract, minoxidil and the like are preferable, and among these, further blood flow From the viewpoint of the improvement effect, it is desirable to use carpronium chloride, tocopherol acetate, assembly extract, nicotinamide, and minoxidil.
Examples of the anti-inflammatory agent (C) used in the present invention include glycyrrhetinic acid and / or a derivative thereof, glycyrrhizic acid and / or a derivative thereof, and specifically include glycyrrhizic acid, ammonium glycyrrhizinate, and glycyrrhizic acid. Trisodium, dipotassium glycyrrhizinate, methyl glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate and the like are preferable. Among these, from the viewpoint of further anti-inflammatory effect and anti-androgenic action, β-glycyrrhetinic acid, The use of dipotassium glycyrrhizinate is desirable.

The component (D) fungicides used in the present invention are isopropylmethylphenol, salicylic acid, hinokitiol, benzalkonium chloride, benzethonium chloride, trichlorocarbanilide, zinc pyrithione, 1-hydroxy-2-pyridone compounds or salts thereof, propolis Of these, isopropylmethylphenol, salicylic acid, zinc pyrithione, 1-hydroxy-2-pyridone compounds or salts thereof are desirable from the viewpoint of further bactericidal effect and safety.
Further, the local stimulant of the component (E) used in the present invention is preferably benzyl nicotinate, vanillyl nonyl acid, etc. Among them, benzyl nicotinate is preferred from the viewpoint of further local stimulating effect and safety. Is desirable.

In the present invention, the cell activator of the component (A), the blood flow improving agent of the component (B), the anti-inflammatory agent of the component (C), the fungicide of the component (D) and the local stimulant of the component (E) In addition, each of the components (A) to (E) contains one type (each individual) or two or more types (up to 5 types), and the components (A) to (E) contain these components. Each content is as follows.
The content of the cell activator serving as the component (A) that can be used is usually 0.001 to 5.0% by mass (hereinafter simply referred to as “%”) with respect to the total amount of the scalp hair cosmetic. 0.01 to 2.0% is preferable, and 0.05 to 1.0% is particularly preferable.
When the content of the component (A) is less than 0.001%, a sufficient cell activation effect may not be obtained. On the other hand, when the content exceeds 5.0%, it is uneconomical.

The content of the blood flow improving agent that can be used as the component (B) is usually 0.001 to 5.0% with respect to the total amount of the scalp hair cosmetic, but is 0.01 to 2.0%. In particular, 0.05 to 1.0% is more preferable.
If the content of component (B) is less than 0.001, sufficient blood flow improvement effect may not be obtained. On the other hand, if it exceeds 5.0%, skin irritation may occur. Increases and does not meet the objectives of the present invention.
The content of the anti-inflammatory agent that can be used as the component (C) is usually 0.001 to 2.0% with respect to the total amount of the scalp hair cosmetic, but 0.01 to 1.0%. In particular, 0.05 to 0.5% is more preferable.
When the content of the component (C) is less than 0.001%, a sufficient anti-inflammatory effect may not be obtained. On the other hand, when the content exceeds 2.0%, it is uneconomical.

The content of the disinfectant that can be used as component (D) is usually 0.001 to 2.0%, preferably 0.005 to 1.0%, based on the total amount of scalp and hair cosmetics. In particular, 0.01 to 0.5% is more preferable.
If the content of the component (D) is less than 0.001%, a sufficient bactericidal effect may not be obtained. On the other hand, if it exceeds 2.0%, skin irritation may occur. Is not suitable for the purpose of the present invention.
The content of the local stimulant that can be used as the component (E) is usually 0.00001 to 2%, preferably 0.00005 to 0.5%, based on the total amount of the scalp hair cosmetic. In particular, 0.0001 to 0.1% is more preferable.
If the content of the component (E) is less than 0.00001%, a sufficient local irritation effect may not be obtained. On the other hand, if it exceeds 2%, the possibility of causing skin irritation increases. This is not suitable for the purpose of the present invention.

The polyhydric alcohol used in the present invention is included in scalp hair cosmetics from the viewpoint of imparting a further refreshing sensation and moisturizing effect. For example, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene Glycol, diethylene glycol, triethylene glycol, pentanediol, isopreneglycol, hexanediol, etc. are preferred, and among these, polyethylene glycol, propylene glycol, glycerin, pentanediol, isoprene glycol are used from the viewpoint of the refreshing feeling. More preferably, the use of polyethylene glycol, propylene glycol, glycerin or pentanediol is desirable.
The polyethylene glycol that can be used is not particularly limited with respect to the average molecular weight defined by the degree of polymerization, but from the viewpoint of skin irritation and production, preferably, the average molecular weight (average of polyethylene glycol 200 listed in cosmetic raw material standards) is preferred. The molecular weight test method is applied mutatis mutandis) to 200-2000, more preferably 200-600.
The polyethylene glycol that can be specifically used is at least one of polyethylene glycol 200, 300, 400, 600, 1000, 1500 (and above, based on cosmetic raw material standards), 1540, 2000 (and above, based on the compositional component standards for cosmetic varieties). Seeds are desirable, and polyethylene glycols 200, 300, 400, and 600 are preferred.

The content of these polyhydric alcohols is usually 0.01 to 10% with respect to the total amount of the scalp hair cosmetic, but is preferably 0.05 to 5%, and more preferably 0.1 to 3%. preferable.
If the content of this polyhydric alcohol is less than 0.01%, a sufficient effect of the polyhydric alcohol content may not be obtained. On the other hand, if it exceeds 10%, it will be uneconomical. Problems such as stickiness will occur.

The organic acid used in the present invention is included in scalp hair cosmetics from the viewpoint of further imparting a refreshing sensation and adjusting the pH in the scalp. Citric acid, succinic acid, malic acid, lactic acid, fumaric acid , Tartaric acid, phytic acid, and the like are preferable. Among these, citric acid, succinic acid, and malic acid are preferably used from the viewpoint of sustaining a refreshing feeling.
The content of these organic acids is 0.01 to 10%, preferably 0.05 to 5%, more preferably 0.1 to 3%, based on the total amount of the scalp hair cosmetic.
If the content of the organic acid is less than 0.01%, a sufficient effect of containing the organic acid may not be obtained. On the other hand, if the content exceeds 10%, the pH becomes too low and skin irritation occurs. It is likely that it will occur and will not meet the purpose of the present invention.

The (l-) menthol used in the present invention is contained in scalp hair cosmetics from the viewpoint of imparting a good refreshing feeling and effect, and may be natural or synthetically obtained.
The content of these menthols is usually 0.001 to 10% with respect to the total amount of the scalp hair cosmetic, but is preferably 0.01 to 5%, and more preferably 0.05 to 3%.
If the menthol content is less than 0.001%, a refreshing sensation may not be obtained. On the other hand, if it exceeds 10%, the possibility of causing skin irritation increases, which is an object of the present invention. It will not conform.

The scalp hair cosmetic of the present invention contains at least one or more selected from the above (A) to (E), a polyhydric alcohol, an organic acid, and menthol, with the remainder being ethanol, water. (Purified water, distilled water, ion-exchanged water, pure water, ultrapure water, etc.), but from the viewpoints of usability, refreshing enhancement, and refreshing sustain, butane and propane More preferably containing a combustible gas selected from isobutane, liquefied petroleum gas (LPG) and dimethyl ether (DME) and / or a compressed gas selected from nitrogen gas, oxygen gas, carbon dioxide gas and nitrous oxide gas. By adopting the form, it is preferable because the refreshing feeling is more persistent.
As the combustible gas, for example, liquefied petroleum gas and dimethyl ether are preferable. Moreover, as compressed gas, nitrogen gas and a carbon dioxide gas are especially preferable, for example, and it is more preferable to use the said combustible gas and compressed gas together from a viewpoint of the long-term stability and usability | use_condition of an aerosol agent.
The blending ratio (mass ratio) of liquefied petroleum gas or dimethyl ether, nitrogen gas and carbon dioxide is liquefied petroleum gas or dimethyl ether / carbon dioxide or nitrogen gas = 95/5 to 99/1, more preferably 96/4 to 98. / 2.
The blending amount of the gas as these propellants is 5 to 50%, more preferably 10 to 45%, and a good refreshing feeling can be obtained within this range.

  When the scalp hair cosmetic composition of the present invention contains a fragrance, the fragrance used is, for example, the fragrance composition described in Japanese Patent Application Laid-Open No. 2003-113019. It is preferable to contain the fragrance composition in an amount of 0.00001 to 50% with respect to the total amount of the hair cosmetic, and more preferably 0.0001 to 30%.

  The scalp hair cosmetic of the present invention can further contain an optional component depending on the purpose of use. Examples of such components include anti-androgen agents, moisturizers, vitamins, amino acids, purified water, ethanol, celluloses, surfactants, fats and oils, ester oils, polymer resins, coloring materials, fragrances, An ultraviolet absorber or the like can be contained.

  The scalp hair cosmetic composition of the present invention can be used in the form (form) of uniform solution, lotion, gel, cream, aerosol and the like according to a conventional method.

  In the scalp hair cosmetic composition of the present invention thus configured, when containing at least one or more selected from the above (A) to (E), a polyhydric alcohol, an organic acid, and menthol, The action of polyhydric alcohol and organic acid works synergistically with the refreshing strength and long-lasting effect of menthol. When this scalp hair cosmetic is applied externally to scalp hair, it shows an excellent refreshing feeling, especially refreshing feeling. Scalp hair cosmetics that are excellent in sustainability, have a good feeling of use, and have a high hair-growth effect.

  EXAMPLES Next, although an Example and a comparative example demonstrate this invention further in detail, this invention is not limited to the following Example etc.

[Examples 1-14 and Comparative Examples 1-5]
The hair growth tonic agents (total amount: 100% by mass) of Examples 1 to 14 and Comparative Examples 1 to 5 having the compositions shown in Tables 1 and 2 below were prepared by a conventional method.
About each obtained hair-growth tonic agent, the following evaluation method evaluated the strength and durability of refreshing feeling, evaluation of a feeling of use (non-stickiness), and the hair-growth effect.
These results are shown in Tables 1 and 2 below.

(Evaluation method for coolness and non-stickiness)
Using the hair-growth tonic agent having each composition shown in Tables 1 and 2 below, the strength and durability of the refreshing feeling and the feeling of use (no stickiness) were evaluated. For 10 men who had many hair loss at the time of shampooing and were aware that their hair had become thin, apply 2mL once to the entire scalp after shampooing and towel drying, and sensory evaluation was performed according to the following criteria .
Evaluation criteria: Ratio of panelists judged to be good ◎: Very good 80% or more ○: Good 60% or more and less than 80% △: Slightly bad 40% or more and less than 60% ×: Poor 40% or less

(Evaluation method for hair growth effect)
The backs of 49-day-old C3H / Heslc mice in the resting period of the hair cycle were depilated using an electric clipper and an electric shaver and subjected to experiments as 10 mice per group. From the next day, 0.1 mL of each test sample was applied once a day to the back from which hair was removed. The hair growth effect of each test sample was measured by measuring the hair growth area of the mouse hair removal back and comparing the hair growth area to the hair removal area. The number of days required for 50% hair growth rate for each test sample was examined, and the number of days that reached 50% hair growth rate was shortened as compared with the case where ethanol alone was applied as “acceleration days” in the table. The hair growth effect was evaluated according to the following evaluation criteria.
Evaluation criteria:
Remarkable: Promotion days 7 days or more Effective: Promotion days 3 days or more and less than 7 days Invalid: Promotion days 0 days or more and less than 3 days

As is clear from the results of Tables 1 and 2, Examples 1 to 14 that are within the scope of the present invention are more refreshing and durable than Comparative Examples 1 to 5 that are outside the scope of the present invention. It has been found that it has excellent properties and a feeling of use (no stickiness) and is excellent in hair-growth effect.
On the other hand, when a comparative example is seen, the comparison which a polyhydric alcohol and an organic acid are not used together in the composition containing 1 type, or 2 or more types chosen from said (A)-(E), and 1-menthol. In the hair-growth tonic agents of Examples 1 to 5, it was found that the refreshing feeling was inferior and the hair-growth effect was inferior.

[Examples 15 to 30]
According to each composition shown in the following Tables 3 to 18 (each dosage form, 100% by mass in total), the essence for scalp (Example 15), hair growth tonic (Examples 16 and 24), hair nourishing agent (Examples 17 to 21), Hair growth sprays (Examples 22 and 28), hair nourishing hair creams (Example 23) and hair growth tonic sprays (Examples 25 to 27, 29 and 30) were prepared by conventional methods.
About the scalp essence of each obtained Example, the hair-growth tonic agent, etc., the said evaluation method evaluated the intensity | strength and durability of refreshing feeling, evaluation of a feeling of use (non-stickiness), and the hair-growth effect. About these evaluation results, it shows to each Table 3-17.

[Example 15, essence for scalp]

[Example 16, hair growth tonic]

[Example 17, hair nourishing agent]

[Example 18, hair nourishing agent]

[Example 19, hair nourishing agent]

[Example 20, hair nourishing agent]

[Example 21, hair nourishing agent]

[Example 22, hair growth spray]

[Example 23, hair nourishing hair cream]
The following formulations A and B were respectively dissolved at 70 ° C., and A was added to B and uniformly emulsified. Furthermore, C was added while cooling to prepare a hair nourishing hair cream.

[Example 24, hair growth tonic]

[Example 25, hair-growth tonic spray]

[Example 26, hair-growth tonic spray]

[Example 27, hair-growth tonic spray]

[Example 28, hair growth spray]

[Example 29, hair-growth tonic spray]

[Example 30, hair growth tonic spray]

  As apparent from the results in Tables 3 to 18, the essence for scalp of Example 15, the hair growth tonic of Examples 16 and 24, the hair nourishing agent of Examples 17 to 21, the hair growth spray of Example 22, and the nourishment of Example 23 Also in hair cosmetics for scalp of hair hair creams, hair growth tonic sprays of Examples 25 to 27 and 29 to 30 and hair growth sprays of Example 28, the strength and durability of refreshing feeling and feeling of use (stickiness) It was found that the hair growth effect was excellent.

The hair cosmetic composition for scalp of the present invention is useful for hair-growth tonic, scalp essence, hair-growth agent, hair-growth spray, hair-growth hair cream, hair-growth tonic spray, etc. It is.

Claims (4)

A scalp hair cosmetic comprising at least one or more selected from the following (A) to (E), a polyhydric alcohol, an organic acid, and menthol.
(A) Pantothenic acid and / or derivative thereof, placenta extract, photosensitizer, biotin, adenine and / or derivative thereof, thymine and / or derivative thereof, guanine and / or derivative thereof, cytosine and / or derivative thereof, uracil and / or Alternatively, a cell activator containing one or more selected from the group consisting of derivatives thereof, astilbine and / or derivatives thereof, and mononitroguaiacol.
(B) A blood flow improving agent containing at least one selected from carpronium chloride, vitamin E derivatives, assembly extract, cephalanthin, nicotinamide, carrot extract, and minoxidil.
(C) The anti-inflammatory agent containing 1 or more types chosen from glycyrrhetic acid and / or its derivative (s), glycyrrhizic acid and / or its derivative (s).
(D) Disinfection containing at least one selected from isopropylmethylphenol, salicylic acid, hinokitiol, benzalkonium chloride, benzethonium chloride, trichlorocarbanilide, zinc pyrithione, 1-hydroxy-2-pyridone compounds or salts thereof, and propolis Agent.
(E) A local stimulant containing one or more selected from benzyl nicotinate and nonyl acid vanillylamide.   The polyhydric alcohol according to claim 1 is at least one selected from the group consisting of polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene glycol, diethylene glycol, triethylene glycol, pentanediol, isoprene glycol, and hexanediol. Scalp hair cosmetics.   A scalp hair cosmetic, wherein the organic acid according to claim 1 is at least one selected from the group consisting of citric acid, succinic acid, malic acid, lactic acid, fumaric acid, tartaric acid, and phytic acid. It contains a combustible gas selected from butane, propane, isobutane, liquefied petroleum gas, and dimethyl ether and / or a compressed gas selected from nitrogen gas, oxygen gas, carbon dioxide gas, and nitrous oxide gas. The scalp hair cosmetic according to any one of claims 1 to 3.