WO2001076540A1 - Hair growth stimulant compositions - Google Patents
Hair growth stimulant compositions Download PDFInfo
- Publication number
- WO2001076540A1 WO2001076540A1 PCT/JP2001/002940 JP0102940W WO0176540A1 WO 2001076540 A1 WO2001076540 A1 WO 2001076540A1 JP 0102940 W JP0102940 W JP 0102940W WO 0176540 A1 WO0176540 A1 WO 0176540A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- hair
- polyhydric alcohol
- hair growth
- acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 229940124563 hair growth stimulant Drugs 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 47
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229960003632 minoxidil Drugs 0.000 claims abstract description 33
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims abstract description 32
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 20
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 19
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 19
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 claims abstract description 16
- 229960003720 enoxolone Drugs 0.000 claims abstract description 16
- MRAMPOPITCOOIN-VIFPVBQESA-N (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide Chemical compound CCOCCCNC(=O)[C@H](O)C(C)(C)CO MRAMPOPITCOOIN-VIFPVBQESA-N 0.000 claims abstract description 15
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229930007845 β-thujaplicin Natural products 0.000 claims abstract description 13
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940041616 menthol Drugs 0.000 claims abstract description 12
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 5
- 230000003779 hair growth Effects 0.000 claims description 30
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 24
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 16
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 13
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 12
- 239000006210 lotion Substances 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 8
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 239000004310 lactic acid Substances 0.000 claims description 7
- 229960003511 macrogol Drugs 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 239000000443 aerosol Substances 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- -1 hinokiti Chemical compound 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 229940023735 panthenyl ethyl ether Drugs 0.000 claims description 2
- 229940113120 dipropylene glycol Drugs 0.000 claims 2
- 229960005150 glycerol Drugs 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 235000011167 hydrochloric acid Nutrition 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 10
- 239000008213 purified water Substances 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- MPDGHEJMBKOTSU-WFJWTYAKSA-N (2s,4as,6as,6br,10s,12as)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid Chemical compound C12C(=O)C=C3C4C[C@@](C)(C(O)=O)CC[C@]4(C)CC[C@@]3(C)[C@]1(C)CCC1[C@]2(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-WFJWTYAKSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 241001529742 Rosmarinus Species 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
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- 230000001070 adhesive effect Effects 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
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- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
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- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
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- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229960002350 guaiazulen Drugs 0.000 description 1
- 230000003700 hair damage Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
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- 239000002932 luster Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
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- 238000010979 pH adjustment Methods 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
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- 125000001232 pantothenyl group Chemical group C(CCNC([C@H](O)C(C)(C)CO)=O)(=O)* 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- TXGSOSAONMOPDL-UHFFFAOYSA-N propan-2-yl 3,4,5-trihydroxybenzoate Chemical compound CC(C)OC(=O)C1=CC(O)=C(O)C(O)=C1 TXGSOSAONMOPDL-UHFFFAOYSA-N 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Definitions
- the present invention relates to a hair restoration composition containing minoxidil as an active ingredient, and more particularly, to a hair restoration composition having an improved feeling in use.
- Minoxidil has the chemical name 6- (1-piperidinyl) -1,2,4-pyrimidinediamine-13-oxide, and its application as a hair restorer is described in U.S. Patent No. 4,139,619. I have. Minoxidil has excellent hair-growth and hair-growth effects when applied externally, so hair growth agents containing minoxidil (hereinafter referred to as “minoxidil preparations”) have been widely accepted and their sales have been record-setting.
- minoxidil preparations are used daily for a long period of time on the head, preparations with excellent feeling in use are required.
- the feeling of use is important for a hair restorer with an increased concentration of minoxydil.
- an object of the present invention is to provide a minoxidil-containing hair growth composition having a higher feeling of use than the currently provided minoxidil preparations. Disclosure of the invention
- the present inventors have conducted intensive studies on the solvent composition and additive compounds of the minoxidil formulation in order to solve the above problems, and as a result, selected a polyvalent alcohol / ethanol / water ternary system as the solvent. By selecting and adding a specific compound to this, when minoxidil is blended at a high concentration, Nevertheless, they have found that a stable and excellent feeling in use can be obtained, and the present invention has been completed.
- the present invention relates to a group comprising 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol and water, and further comprising menthol, vitamin E acetate, pantothenyl ethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride.
- An object of the present invention is to provide a hair growth composition comprising one or more selected components.
- the present invention comprises 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, menthol and water, and further comprises a group consisting of vitamin E acetate, pantothenylethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride.
- An object of the present invention is to provide a hair growth composition comprising one or more selected components.
- the present invention provides a group comprising 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, vitamin E acetate and water, and further comprising menthol, panthenylethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride.
- An object of the present invention is to provide a hair growth composition comprising one or more components selected from the group consisting of:
- the present invention comprises 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, pantothenyl ethyl ether and water, and further contains menthol, vitamin E acetate, hinokitiol, glycyrrhetinic acid and diphenhydric hydrochloride.
- Another object of the present invention is to provide a hair growth composition comprising one or more components selected from the group consisting of dramin.
- the content of minoxidil as an active ingredient is in the range of 1 to 6% by mass (hereinafter, simply indicated by “%”).
- the effect of the present invention is remarkable in a hair growth composition containing 2% or more.
- the solvent system for dissolving this minoxidil is a ternary system composed of polyhydric alcohol, ethanol and water.
- the amount of each component of the solvent system is not particularly limited, but the amount of ethanol is about 25 to 75% and the amount of water is about 5 to 30% in the final composition. Is preferred.
- the polyhydric alcohol is preferably used as a solubilizer in an amount of 5 to 30%, and more preferably 8 to 20% in terms of usability.
- polyhydric alcohol 1,3-butylendalcol, glycerin, dipropylene glycol, macrogol 300, macrogol 400, macrogol 600, etc.
- glycerin 1,3-butylendalcol, glycerin, dipropylene glycol, macrogol 300, macrogol 400, macrogol 600, etc.
- the components to be added to and mixed with the hair growth composition of the present invention were selected from the group consisting of menthol, vitamin E acetate, pantothenylethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride.
- Ingredients hereinafter, referred to as “selected ingredients”.
- selected ingredients those having particularly high effectiveness include menthol, vitamin E acetate and pantothenyl ethyl ether, and it is more preferable to add these as essential components.
- the amount of the selective active ingredient to be added is not particularly limited, and can be determined experimentally in consideration of the stability of minoxidil used or the composition of the solvent system.
- menthol which is a particularly preferred selection component, is preferably blended in an amount of about 0.2 to 0.4% in the final composition.
- vitamin E acetate is 0.016 to 0.15%
- pantothenyl ethyl ether is 0.5 to 1.5%
- hinokitiol is 0.02 to 0.08%
- glycyrrhetinic acid is 0.08%.
- various components used in general external preparations for example, excipients, vasodilators (capium chloride, dimethyl nicotinate, benzyl nicotinate, Extracts, Panax ginseng extract, Toragarachi tincture, etc., antihistamines (isotipendyl hydrochloride, etc.), anti-inflammatory agents (guaiazulene, etc.), keratolytics (urea, salicylic acid, etc.), fungicides (chlorhexidine dalconate, isopropylmethylphenol) , Quaternary ammonium salt, pyroctone laminate, etc.), humectant (sodium hyaluronate, chondroitin sulfate, etc.), various animals and plants (yew, buttonamp, kanzo, guinea pig, batsushi, beet, power Wara
- the hair growth composition of the present invention be substantially free of a surfactant.
- the hair growth composition of the present invention is prepared by blending the above components according to a conventional method.
- the pH of the hair growth composition is about 5.5 to 9.5. It is more preferable to set the temperature in the range of about 5.5 to 6.5, which is particularly weakly acidic.
- an appropriate acid and / or base can be used as a pH adjuster.
- a pH adjuster examples include citric acid, hydrochloric acid, lactic acid, and phosphoric acid. be able to.
- the hair growth composition of the present invention thus obtained can be used as a suitable external preparation such as a lotion, an aerosol, a tonic, a cream, an ointment, a gel and the like.
- Example 1 Example 1
- the present invention 2 The present invention 3
- the present invention 4 The present invention 5
- the present invention 6 The present invention 7
- the present invention 8 The present invention 9
- Invention product 23 Invention product 24 Invention product 25 Invention product 26 Invention product 27 Invention product 28
- 1,3-butylene glycol 5.0 g 1 0.0 g chryselino 1 5.0 g 5.0 g 3.0 g
- the feeling of use of the hair growth lotion shown in Table 9 and Table 10 was evaluated by a sensory test by four expert panelists in their 20s to 40s.
- the evaluation was performed by a left-right paired comparison using a half head.
- the right side of the head is the non-administration site, and the left side is the lotion application site, applying 1 mL twice a day for 3 weeks, and evaluating the hair condition every week according to the evaluation criteria in Table 11 did.
- Table 12 shows the average scores of the four panelists.
- Table 9 Inventive product 47 Inventive product 48 Inventive product 49 Minoxidil 1.0 g 1.0 g 1.0 g
- Vitamin E acetate 0.08 g
- Important elements of beautiful and healthy hair include firmness, shine, and moistness.
- the effect of the hair growth lotion of the present invention on these factors was determined by a 3-week usability test.
- the hair growth lotion of the example showed a higher effect from an earlier stage than the hair growth lotion of the comparative example. Furthermore, it has been found that an unprecedented feeling of use is obtained by combining a plurality of selected components. In addition, the effect of improving the usability was obtained in a well-balanced manner for all three factors, and it was found that the composition had an overall effect of improving the usability as a hair preparation. that's all
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Abstract
Hair growth stimulant compositions imparting an improved feel in using which contain 1 to 6% by mass of minoxidil, a polyhydric alcohol, ethanol and water together with at least one component selected from the group consisting of menthol, vitamin E acetate, pantothenyl ethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride.
Description
明 細 害 育毛組成物 Hair damage composition
技 術 分 野 Technical field
本発明は、 ミノキシジルを有効成分とする育毛組成物に関し、 更に詳 細には、 使用感を高めた育毛組成物に関する。 背 景 技 術 The present invention relates to a hair restoration composition containing minoxidil as an active ingredient, and more particularly, to a hair restoration composition having an improved feeling in use. Background technology
ミノキシジルは化学名を 6 — （ 1 —ピペリジニル） 一 2， 4 —ピリミ ジンジァミン一 3—オキサイ ドと称し、 米国特許第 4， 1 3 9 , 6 1 9号 に育毛剤としての適応が記載されている。 そして、 ミノキシジルは、 外 用により優れた育毛、 養毛作用があるため、 ミノキシジルを配合した育 毛剤 （以下、 「ミノキシジル製剤」 という） は広く受け入れられ、 その 販売高も記録的である。 Minoxidil has the chemical name 6- (1-piperidinyl) -1,2,4-pyrimidinediamine-13-oxide, and its application as a hair restorer is described in U.S. Patent No. 4,139,619. I have. Minoxidil has excellent hair-growth and hair-growth effects when applied externally, so hair growth agents containing minoxidil (hereinafter referred to as “minoxidil preparations”) have been widely accepted and their sales have been record-setting.
ミノキシジル製剤は、 頭部に長期間にわたって毎日使用するものであ るから、 使用感においても優れた製剤が求められている。 特に、 ミノキ シジルの濃度を高めた育毛剤にあってはその使用感は重要となる。 Since minoxidil preparations are used daily for a long period of time on the head, preparations with excellent feeling in use are required. In particular, the feeling of use is important for a hair restorer with an increased concentration of minoxydil.
従って本発明の目的は、現在提供されているミノキシジル製剤よりも、 その使用感を高めたミノキシジル含有の育毛組成物を提供することにあ る。 発 明 の 開 示 Accordingly, an object of the present invention is to provide a minoxidil-containing hair growth composition having a higher feeling of use than the currently provided minoxidil preparations. Disclosure of the invention
本発明者らは、 上記課題を解決すべく、 ミノキシジル製剤の溶剤組成 や添加配合物について、 鋭意研究を行った結果、 溶剤として、 多価アル コール エ夕ノール/水の三成分系を選択し、 これに特定の化合物を選 択、 添加することにより、 高い濃度でミノキシジルを配合した場合にお
いても、 安定で、 しかも優れた使用感が得られることを見出し、 本発明 を完成した。 The present inventors have conducted intensive studies on the solvent composition and additive compounds of the minoxidil formulation in order to solve the above problems, and as a result, selected a polyvalent alcohol / ethanol / water ternary system as the solvent. By selecting and adding a specific compound to this, when minoxidil is blended at a high concentration, Nevertheless, they have found that a stable and excellent feeling in use can be obtained, and the present invention has been completed.
すなわち本発明は、 1 〜 6質量％のミノキシジル、 多価アルコール、 エタノール及び水を含み、 さらにメントール、 ビタミン Eアセテート、 パン卜テニルェチルエーテル、 ヒノキチオール、 グリチルレチン酸およ び塩酸ジフェンヒ ドラミンから成る群より選ばれる成分の 1種又は 2種 以上を含有してなる育毛組成物を提供するものである。 That is, the present invention relates to a group comprising 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol and water, and further comprising menthol, vitamin E acetate, pantothenyl ethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride. An object of the present invention is to provide a hair growth composition comprising one or more selected components.
また本発明は、 1 ~ 6質量％のミノキシジル、 多価アルコール、 エタ ノール、 メントール及び水を含み、 さらにビタミン Eアセテート、 パン 卜テニルェチルエーテル、 ヒノキチオール、 グリチルレチン酸および塩 酸ジフェンヒドラミンから成る群より選ばれる成分の 1 種又は 2種以上 を含有してなる育毛組成物を提供するものである。 Further, the present invention comprises 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, menthol and water, and further comprises a group consisting of vitamin E acetate, pantothenylethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride. An object of the present invention is to provide a hair growth composition comprising one or more selected components.
さらに本発明は、 1 〜 6質量％のミノキシジル、 多価アルコール、 ェ 夕ノール、 ビタミン Eアセテート及び水を含み、 さらにメントール、 パ ン卜テニルェチルエーテル、 ヒノキチオール、 グリチルレチン酸および 塩酸ジフェンヒドラミンから成る群より選ばれる成分の 1 種又は 2種以 上を含有してなる育毛組成物を提供するものである。 Further, the present invention provides a group comprising 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, vitamin E acetate and water, and further comprising menthol, panthenylethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride. An object of the present invention is to provide a hair growth composition comprising one or more components selected from the group consisting of:
さらにまた本発明は、 1 〜 6質量％のミノキシジル、 多価アルコール、 エタノール、 パン卜テニルェチルエーテル及び水を含み、 さらにメン卜 ール、 ビタミン Eアセテート、 ヒノキチオール、 グリチルレチン酸およ び塩酸ジフェンヒ ドラミンから成る群より選ばれる成分の 1 種又は 2種 以上を含有してなる育毛組成物を提供するもである。 発明を実施するための最良の形態 Further, the present invention comprises 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, pantothenyl ethyl ether and water, and further contains menthol, vitamin E acetate, hinokitiol, glycyrrhetinic acid and diphenhydric hydrochloride. Another object of the present invention is to provide a hair growth composition comprising one or more components selected from the group consisting of dramin. BEST MODE FOR CARRYING OUT THE INVENTION
本発明の育毛組成物において、 有効成分であるミノキシジルは、 1 〜 6質量％ (以下、 単に 「％」 で示す） の範囲であるが、 ミノキシジルを
2 %以上配合した育毛組成物において本発明の効果が著しいものとな る。 In the hair growth composition of the present invention, the content of minoxidil as an active ingredient is in the range of 1 to 6% by mass (hereinafter, simply indicated by “%”). The effect of the present invention is remarkable in a hair growth composition containing 2% or more.
このミノキシジルを溶解するための溶剤系は、 多価アルコール、 エタ ノ一ルおよび水で構成される三成分系である。 この溶剤系の各成分の配 合量には、 特に制約はないが、 最終組成物中で、 エタノールの配合量が 2 5〜 7 5 %程度、水の配合量が 5〜 3 0 %程度とすることが好ましい。 多価アルコールは溶解補助剤としては 5〜 3 0 %が好ましく、 使用感 の点からは 8〜 2 0 %が好ましい。 The solvent system for dissolving this minoxidil is a ternary system composed of polyhydric alcohol, ethanol and water. The amount of each component of the solvent system is not particularly limited, but the amount of ethanol is about 25 to 75% and the amount of water is about 5 to 30% in the final composition. Is preferred. The polyhydric alcohol is preferably used as a solubilizer in an amount of 5 to 30%, and more preferably 8 to 20% in terms of usability.
また、 上記の多価アルコールとしては、 1 ， 3—プチレンダリコール、 グリセリン、 ジプロピレングリコール、 マクロゴール 3 0 0、 マクロゴ ール 4 0 0、 マクロゴール 6 0 0等を使用することができるが、 特にこ れらを 2種以上組み合わせて用いることが好ましい。 Also, as the above polyhydric alcohol, 1,3-butylendalcol, glycerin, dipropylene glycol, macrogol 300, macrogol 400, macrogol 600, etc. can be used. It is particularly preferable to use a combination of two or more of these.
一方、 本発明の育毛組成物に添加、 配合される成分としては、 メン卜 ール、 ビタミン Eアセテート、 パン卜テニルェチルエーテル、 ヒノキチ オール、 グリチルレチン酸および塩酸ジフェンヒドラミンから成る群よ リ選ばれた成分 （以下、 「選択成分」 という） が挙げられる。 この選択 成分のうち、 特に有効性が高いものとしては、 メントール、 ビタミン E アセテート及びパン卜テニルェチルエーテルが挙げられ、 これらを必須 成分として加えておくことがより好ましい。 On the other hand, the components to be added to and mixed with the hair growth composition of the present invention were selected from the group consisting of menthol, vitamin E acetate, pantothenylethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride. Ingredients (hereinafter, referred to as “selected ingredients”). Among these optional components, those having particularly high effectiveness include menthol, vitamin E acetate and pantothenyl ethyl ether, and it is more preferable to add these as essential components.
これら選択活性成分の添加量は、 特に制約はなく、 使用感ゃミノキシ ジルの安定性あるいは溶剤系組成等を考慮しながら実験的に定めること ができる。 例えば、 特に好ましい選択成分であるメントールは、 最終組 成物中で 0 . 2〜 0 . 4 %程度となるよう配合することが好ましい。 The amount of the selective active ingredient to be added is not particularly limited, and can be determined experimentally in consideration of the stability of minoxidil used or the composition of the solvent system. For example, menthol, which is a particularly preferred selection component, is preferably blended in an amount of about 0.2 to 0.4% in the final composition.
また、 ビタミン Eアセテートは 0 . 0 1 6 ~ 0 . 1 5 %、 パン卜テニル ェチルエーテルは 0 . 5〜 1 . 5 %、 ヒノキチオールは 0 . 0 2 ~ 0 . 0 8 %、 グリチルレチン酸は 0 . 0 2〜 0 . 1 5 %、 塩酸ジフエンヒドラミン
は 0 . 0 2〜 0 . Ί 5 %程度となるよう配合することが好ましい。 In addition, vitamin E acetate is 0.016 to 0.15%, pantothenyl ethyl ether is 0.5 to 1.5%, hinokitiol is 0.02 to 0.08%, and glycyrrhetinic acid is 0.08%. 0 2 to 0.15%, diphenhydramine hydrochloride Is preferably blended so as to be about 0.02 to about 0.005%.
本発明の育毛剤組成物においては、 上記した成分の他、 一般の外用剤 に使用される種々の成分、 例えば、 賦形剤、 血管拡張剤 （塩化カルプ口 二ゥ厶、 ニコチン酸ベンジル、 センプリ抽出液、 才タネニンジンエキス、 卜ゥガラシチンキなど）、 抗ヒスタミン剤 （塩酸イソチペンジルなど）、 抗炎症剤 （グアイァズレンなど）、 角質溶解剤 （尿素、 サリチル酸など）、 殺菌剤（ダルコン酸クロルへキシジン、イソプロピルメチルフエノール、 第 4級アンモニゥ厶塩、 ピロク 卜ン才ラミンなど）、 保湿剤 （ヒアル口 ン酸ナトリウム、 コンドロイチン硫酸など）、 各種動植物 （ィチイ、 ボ タンピ、 カンゾゥ、 才卜ギリソゥ、 附子、 ビヮ、 力ワラョモギ、 コンフ リー、 ァシタバ、 サフラン、 サンシシ、 ローズマリー、 セージ、 モッコ ゥ、 セィモッコゥ、 ホップ、 ブラセンタなど） の抽出物、 ビタミン類 （酢 酸レチノール、 塩酸ピリ ドキシン、 ァスコルビン酸、 硝酸チアミン、 シ ァノコバラミン、 ビ才チンなど）、 抗酸化剤 （ジブチルヒ ドロキシトル ェン、 ピロ亜硫酸ナトリウム、 トコフエロール、 ェデ卜酸ナトリウム、 ァスコルビン酸、 イソプロピルガレ一卜など）、 溶解補助剤 （アジピン 酸ジイソプロピル、 ミリスチン酸イソプロピル、 各種植物油、 各種動物 油、 炭化水素類など）、 代謝賦活剤 （パンテノールなど）、 ゲル化剤 （水 溶性高分子など）、 粘着剤、 香料、 清涼化剤 （ハツ力油、 カンフルなど）、 染料などの通常使用される成分を本発明の効果を損なわない範囲で配合 することができる。 In the hair restorer composition of the present invention, in addition to the above-mentioned components, various components used in general external preparations, for example, excipients, vasodilators (capium chloride, dimethyl nicotinate, benzyl nicotinate, Extracts, Panax ginseng extract, Toragarachi tincture, etc., antihistamines (isotipendyl hydrochloride, etc.), anti-inflammatory agents (guaiazulene, etc.), keratolytics (urea, salicylic acid, etc.), fungicides (chlorhexidine dalconate, isopropylmethylphenol) , Quaternary ammonium salt, pyroctone laminate, etc.), humectant (sodium hyaluronate, chondroitin sulfate, etc.), various animals and plants (yew, buttonamp, kanzo, guinea pig, batsushi, beet, power Waratomogi, confectionery, ashitaba, saffron, sanshishi, rosemary, sey , Mocco, simokko, hops, bracenta, etc.), vitamins (retinol acetate, pyridoxine hydrochloride, ascorbic acid, thiamine nitrate, cyanocobalamin, biscuitin, etc.), antioxidants (dibutylhydroxytoluene, Sodium pyrosulfite, tocopherol, sodium edetate, ascorbic acid, isopropyl gallate, etc., solubilizers (diisopropyl adipate, isopropyl myristate, various vegetable oils, various animal oils, hydrocarbons, etc.), metabolic activators Normally used components such as (eg, panthenol), gelling agents (eg, water-soluble polymers), adhesives, fragrances, refreshing agents (eg, heart oil, camphor), and dyes do not impair the effects of the present invention. It can be blended in the range.
しかしながら、 界面活性剤の添加は、 ミノキシジルの皮膚吸収に影響 を与え、 また使用感を低下させるため、 本発明の育毛組成物は実質的に 界面活性剤を含まないものとすることが好ましい。 However, since the addition of a surfactant affects the skin absorption of minoxidil and reduces the feeling of use, it is preferable that the hair growth composition of the present invention be substantially free of a surfactant.
本発明の育毛組成物の調製は、 常法に従い、 上記各成分を配合するこ とにより調製される。 この場合、 育毛組成物の p Hは、 5 . 5〜 9 . 5程
度の範囲とすることが望ましく、 特に、 弱酸性である 5. 5〜 6. 5程度 の範囲とすることがよリ望ましい。 The hair growth composition of the present invention is prepared by blending the above components according to a conventional method. In this case, the pH of the hair growth composition is about 5.5 to 9.5. It is more preferable to set the temperature in the range of about 5.5 to 6.5, which is particularly weakly acidic.
上記の P H調整に当たっては、 適当な酸および/または塩基を p H調 整剤として使用することができ、 そのような P H調整剤の例としては、 クェン酸、 塩酸、 乳酸、 リン酸等を挙げることができる。 In the above pH adjustment, an appropriate acid and / or base can be used as a pH adjuster. Examples of such a pH adjuster include citric acid, hydrochloric acid, lactic acid, and phosphoric acid. be able to.
かく して得られる本発明の育毛組成物は、 ローション剤、 エアゾール 剤、 卜ニック剤、 クリーム剤、 軟膏剤、 ゲル剤などの適当な外用製剤と し、 使用することができる。 The hair growth composition of the present invention thus obtained can be used as a suitable external preparation such as a lotion, an aerosol, a tonic, a cream, an ointment, a gel and the like.
実 施 例 Example
以下に実施例を挙げ、 本発明をさらに具体的に説明するが、 本発明は これら実施例等により何ら制約されるものではない。 実 施 例 1 Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited by these Examples and the like. Example 1
ミノキシジル 1 .0 g、 L—メントール 0. 3 g、 パン卜テニルェチル エーテル 0. 0 8 g、 1 , 3 -プチレングリコール 1 0. 0 gおよびエタ ノール 6 0. 0 gを混合、 攪拌して溶解し、 さらに精製水を加えて 1 0 O m Lとし、 ローション剤 （本発明品 1 ) を得た。 このローション剤の p Hは、 8. 5であった。 実 施 例 2 Mix and stir 1.0 g of minoxidil, 0.3 g of L-menthol, 0.08 g of pantothenylethyl ether, 10.0 g of 1,3-butylene glycol and 60.0 g of ethanol. After dissolving, purified water was added to make 10 OmL, and a lotion agent (Product 1 of the present invention) was obtained. The pH of this lotion was 8.5. Example 2
実施例 1 と同様にして、 表 1 に示す本発明品 2 ~ 9および表 2に示す 比較品 1 〜 3のローション剤を調製した。 本発明品と比較品について髪 の手触りの良さについて検討したところ、 本発明品の方が優れていた。 ( 組 成 ）
In the same manner as in Example 1, lotions of present invention products 2 to 9 shown in Table 1 and comparative products 1 to 3 shown in Table 2 were prepared. When the good touch of hair was examined for the product of the present invention and the comparative product, the product of the present invention was superior. (Composition)
本発明品 2 本発明品 3 本発明品 4 本発明品 5 本発明品 6 本発明品 7 本発明品 8 本発明品 9 ミノキシジル 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 3.0 ε 5.0 gThe present invention 2 The present invention 3 The present invention 4 The present invention 5 The present invention 6 The present invention 7 The present invention 8 The present invention 9 Minoxidil 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 3.0 ε 5.0 g
L一メン! ^一ル 0.3 g 0.3 g 0.3 g ビタミン Eアセテート 0.08 g L one men! ^ One 0.3 g 0.3 g 0.3 g vitamin E acetate 0.08 g
バン卜テニルェチルエーテル 1.0 g Banthenyl ether 1.0 g
ヒノキチ才一ル 0.05 g Hinokichi Saiichiru 0.05 g
グリチルレチン酸 0.1 g Glycyrrhetinic acid 0.1 g
塩酸ジフェンヒドラミン 0.1 Diphenhydramine hydrochloride 0.1
1 , 3—プチレングリコール 1 0.0 g 10.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g エタノール 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 70.0 g 60.0 g 60.0 g クェン酸 適 量 精製水 （全量） 10 OmL 10 OmL 1 0 OmL 10 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 Om L 1,3-butylene glycol 1 0.0 g 10.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g Ethanol 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 70.0 g 60.0 g 60.0 g Amount Purified water (total) 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL
PH 8.5 8.5 8.5 7.7 7.2 7.2 8.8 6.0
PH 8.5 8.5 8.5 7.7 7.2 7.2 8.8 6.0
表 2 比較品 1 比較例 2 比較例 3 ミノキシジル 1.0 g 3.0 g Table 2 Comparative product 1 Comparative example 2 Comparative example 3 Minoxidil 1.0 g 3.0 g
1， 3—ブチレングリコー Jレ 1 0.0 g 1 0.0 g 1,3-butylene glycol J 10.0 g 1 0.0 g
エタノール 60.0 g 60.0 g Ethanol 60.0 g 60.0 g
クェン酸 Cuenoic acid
精製 水 （全量） 1 0 OmL 1 0 OmL Purified water (total) 10 OmL 10 OmL
PH 8.4 8.8 6.0 PH 8.4 8.8 6.0
実 施 例 3 Example 3
実施例 1 と同様にして、 表 3 表 8に示す本発明品 1 0〜 4 6のロー ション剤を調製した。 In the same manner as in Example 1, lotions of present invention products 10 to 46 shown in Table 3 and Table 8 were prepared.
( 組 成 ） o o o赒
(Composition) ooo 赒
O O
本発明品 16 本発明品 17 本発明品 18 本発明品 19 本発明品 20 本発明品 21 本発明品 22 ミノキシジル 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 gInventive product 16 Inventive product 17 Inventive product 18 Inventive product 19 Inventive product 20 Inventive product 21 Inventive product 22 Minoxidil 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g
L一メントール 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g ビタミン Eアセテート 0.08 g 0.08 g 0.08 g 0.08 g ― ― 0.08 g パン卜テニルェチルエーテル ― ― 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 十ナ才—— レ L-menthol 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g Vitamin E acetate 0.08 g 0.08 g 0.08 g 0.08 g--0.08 g Pantothenyl ethyl ether--1.0 g 1.0 g 1.0 g 1.0 g 1.0 g Ten years old
グリチルレチン酸 ― - ― ― ― ― 0.1 g zn ^z. n i gGlycyrrhetinic acid------0.1 g zn ^ z.n i g
1 , 3一プチレンダリコール 5.0 g 8.0 g 20.0 g グリセリン 5.0 g 2.0 g 3.0 g 1,3 Petit Lendallicol 5.0 g 8.0 g 20.0 g Glycerin 5.0 g 2.0 g 3.0 g
ジプロピレングリコ一ル 20.0 g 20.0 g 7.0 g Dipropylene glycol 20.0 g 20.0 g 7.0 g
マクロゴール 400 1 0.0 g Macrogol 400 1 0.0 g
エタノール 60.0 g 60.0 g 60.0 g 50.0 g 60.0 g 60.0 g 40.0 g 乳 酸 0.5 g Ethanol 60.0 g 60.0 g 60.0 g 50.0 g 60.0 g 60.0 g 40.0 g Lactic acid 0.5 g
リ ン 酸 適 量 Phosphoric acid
塩 酸 適 量 Hydrochloric acid qs
水酸ィヒナ卜リウ厶 適 量 適 量 精製水 （全量） 1 0 OmL 1 0 OmL 1 0 Om L 1 0 OmL 1 0 OmL 1 0 OmL 1 00 m LHydroxyl triadium qs qq.purified water (total) 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 100 mL
ΡΗ 8.5 6.0 9.0 5.8 9.0 5.5 9.0
ΡΗ 8.5 6.0 9.0 5.8 9.0 5.5 9.0
本発明品 23 本発明品 24 本発明品 25 本発明品 26 本 明品 27 本発明品 28 Invention product 23 Invention product 24 Invention product 25 Invention product 26 Invention product 27 Invention product 28
¾ノキンンリレ 3.0 g 3.0 g 3.0 g 3.0 g 3.0 g .0 g 3.0 g¾ 3.0 g 3.0 g 3.0 g 3.0 g 3.0 g .0 g 3.0 g
L一メン! ^一 Jレ 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g ビタミン Eァセテ一卜 0.08 g 0.08 g 0.08 g 0.08 g 0.08 g パン卜テニル工チルエーテル 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g ヒノキチオール 0.05 g グリチルレチン酸 0. 1 g 塩酸ジフェンヒドラミン 0. 1 g0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g Vitamin E acetate 0.08 g 0.08 g 0.08 g 0.08 g 0.08 g Pantothenyl tyl ether 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g Hinokitiol 0.05 g Glycyrrhetinic acid 0.1 g Diphenhydramine hydrochloride 0.1 g
1 , 3—ブチレングリコール 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g エタノール 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 70.0 g 60.0 g 乳 酸 適 量 1, 3-butylene glycol 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g 1 0.0 g Ethanol 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 70.0 g 60.0 g Lactic acid
リ ン酸 0.5 g Phosphoric acid 0.5 g
塩 酸 適 量 Hydrochloric acid qs
水酸化ナ卜リウム M 量 適 量 精製水 （全量） 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmLSodium hydroxide M amount Appropriate amount Purified water (total amount) 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL
P H 8.5 6.0 8.9 5.9 8.4 5.5 8.0
PH 8.5 6.0 8.9 5.9 8.4 5.5 8.0
表 6 本発明品 30 本発明品 31 本発明品 32 本発明品 33 本発明品 34 ミノキシジル 3.0 g 3.0 g 3.0 g 3.0 g 3.0 gTable 6 Inventive product 30 Inventive product 31 Inventive product 32 Inventive product 33 Inventive product 34 Minoxidil 3.0 g 3.0 g 3.0 g 3.0 g 3.0 g
L一メン! ^一ル 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g ビタミン Eァセテ一ト 0.08 g 0.08 g 0.08 g ― ― パン卜テニルェチルエーテル 一 1.0 g 1.0 g 1.0 g 1.0 g ヒノキチオール 一 ― ― ― ― グリ千 jレレ千1 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g Vitamin E acetate 0.08 g 0.08 g 0.08 g ― ― Pantothenyl ethyl ether 1.0 g 1.0 g 1.0 g 1.0 g Hinokitiol 1 ― ― ― - Gris thousand j Lele thousand 1
塩酸ジフェンヒドラミン 一 ― ― ―Diphenhydramine hydrochloride ― ― ―
1 , 3—ブチレングリコ一ノレ 8.0 g 1,3-Butylene glycol 8.0 g
グリセリン 2.0 g 3.0 g ジプロピレングリコール 20.0 g 20.0 g 7.0 g マクロゴール 400 1 0.0 g Glycerin 2.0 g 3.0 g Dipropylene glycol 20.0 g 20.0 g 7.0 g Macrogol 400 1 0.0 g
エタノール 60.0 g 60.0B 50.0 g 60.0 g 60.0 g 乳 酸 Ethanol 60.0 g 60.0B 50.0 g 60.0 g 60.0 g Lactic acid
リ ン 酸 適 量 Phosphoric acid
塩 酸 適 量 水酸化ナ卜リウム Hydrochloric acid appropriate amount
精製水 （全量） 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmLPurified water (total) 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL
PH 8.5 9.0 5.7 8.9 5.5
PH 8.5 9.0 5.7 8.9 5.5
本発明品 35 本発明品 36 本発明品 37 本発明品 38 本発明品 39 本発明品 40 ミノキシジル 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g Inventive product 35 Inventive product 36 Inventive product 37 Inventive product 38 Inventive product 39 Inventive product 40 Minoxidil 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g
L一メン! ^一ル 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g ビタミン Eァセテ一卜 0.08 g 0.08 g 0.08 g 0.08 g パン卜テニルェチルエーテル 1， 0 g 1.0 g 1.0 g 1.0 g ヒノキチオール ― ― 0.05 g グリチルレチン酸 0.1 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g Vitamin E acetate 0.08 g 0.08 g 0.08 g 0.08 g Pantothenyleethyl ether 1, 0 g 1.0 g 1.0 g 1.0 g Hinokitiol- ― 0.05 g glycyrrhetinic acid 0.1
塩酸ジフェンヒドラミン 0.1 g Diphenhydramine hydrochloride 0.1 g
1， 3—プチレングリコール 1 0.0 g 20.0 g 1 0.0 g 1 0.0 g 1 0. Og 1 0.0 g エタノール 60.0 g 50.0 g 60.0 g 60.0 g 40.0 g 60.0 g クェン酸 適 量 1.0 g 適 量 -4 乳 酸 適 量 1,3-butylene glycol 1 0.0 g 20.0 g 1 0.0 g 1 0.0 g 1 0. Og 1 0.0 g Ethanol 60.0 g 50.0 g 60.0 g 60.0 g 40.0 g 60.0 g Cunic acid qs 1.0 g qs -4 Lactic acid Appropriate amount
リ ン 酸 適 量 Phosphoric acid
塩 酸 適 量 Hydrochloric acid qs
水酸化ナ卜リウ厶 適 量 NaOH hydroxide
精製水 （全量） 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL Purified water (total) 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL
PH 6.0 6.0 6.5 6.0 5.5 6.0
PH 6.0 6.0 6.5 6.0 5.5 6.0
本発明品 41 本発明品 42 本発明品 43 本発明品 44 本発明品 45 本発明品 46 ミノキシジル 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g し一メントール 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g ビタミン Εアセテート 0.08 g 0.08 g 0.08 g ― 0.08 g パントァ一ルエナルエーアル 1.0 g 1.0 g 1.0 g 1.0 g Inventive product 41 Inventive product 42 Inventive product 43 Inventive product 44 Inventive product 45 Inventive product 46 Minoxidil 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g 5.0 g Shimomenthol 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g 0.3 g Vitamin Εacetate 0.08 g 0.08 g 0.08 g ― 0.08 g Pantoal enaleal 1.0 g 1.0 g 1.0 g 1.0 g
1 , 3—ブチレングリコール 5.0 g 1 0.0 g クリセリノ 1 5.0 g 5.0 g 3.0 g 1,3-butylene glycol 5.0 g 1 0.0 g chryselino 1 5.0 g 5.0 g 3.0 g
ジプロピレングリコール 1 5.0 g 20.0 g 7.0 g Dipropylene glycol 1 5.0 g 20.0 g 7.0 g
マクロゴール 400 1 0.0 g Macrogol 400 1 0.0 g
エタノール 40.0 g 60.0 g 50.0 g 60.0 g 60.0 g 60.0 g Ethanol 40.0 g 60.0 g 50.0 g 60.0 g 60.0 g 60.0 g
00 クェン酸 1.0 g 適 重 乳 酸 1 .5 g 00 1.0 g of citric acid 1.5 g of suitable heavy lactic acid
リ ン 酸 適 量 Phosphoric acid
塩 酸 適 量 Hydrochloric acid qs
水酸化ナ卜リウ厶 適 量 適 量 Sodium hydroxide appropriate amount appropriate amount
精製水 （全量） 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL 1 0 OmL Purified water (total) 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL 10 OmL
PH 9.5 6.0 5.6 5.8 5.5 6.5
PH 9.5 6.0 5.6 5.8 5.5 6.5
実施例 1 で調製したローション剤 3 0 m Lをエアゾール缶に充填し、 さらにジメチルエーテル 7 0 m Lを加えてエアゾール剤とした。 試 験 例 30 ml of the lotion prepared in Example 1 was filled into an aerosol can, and 70 ml of dimethyl ether was further added to obtain an aerosol. Test example
2 0〜 4 0代の専門パネラー 4名により、 表 9及び表 1 0に示した育 毛ローションの使用感を官能試験により評価した。 The feeling of use of the hair growth lotion shown in Table 9 and Table 10 was evaluated by a sensory test by four expert panelists in their 20s to 40s.
評価方法としては、ハーフへッドによる左右一対比較により実施した。 すなわち、 頭部の右側は非投与部位とし、 左側をローション投与部位と して、 1 日 2回 1 mLの塗布を 3週間行い、 1週間毎に頭髪の状態を表 1 1 の評価基準に従い評価した。 パネラー 4名の平均点を表 1 2に示す。 表 9 本発明品 47 本発明品 48 本発明品 49 ミノキシジル 1.0 g 1.0 g 1.0 g The evaluation was performed by a left-right paired comparison using a half head. In other words, the right side of the head is the non-administration site, and the left side is the lotion application site, applying 1 mL twice a day for 3 weeks, and evaluating the hair condition every week according to the evaluation criteria in Table 11 did. Table 12 shows the average scores of the four panelists. Table 9 Inventive product 47 Inventive product 48 Inventive product 49 Minoxidil 1.0 g 1.0 g 1.0 g
L一メントール 0.3 g 0.3 g ビタミン Eァセテ一卜 0.08 g 0.08 g 0.08 g パン卜テニルェチルエーテル 1.0 g 1.0 g 1.0 g ヒノキチオール 0.05 g グリチルレチン酸 0.1 g 塩酸ジフェンヒドラミン 0.1 0.1 g 0.1 L-menthol 0.3 g 0.3 g Vitamin E acetate 0.08 g 0.08 g 0.08 g Pantothenylethyl ether 1.0 g 1.0 g 1.0 g Hinokitiol 0.05 g Glycyrrhetinic acid 0.1 g Diphenhydramine hydrochloride 0.1 0.1 g 0.1
1 , 3—プチレングリコール 10.0 g 10.0 g 1 0.0 g エタノール 60.0 g 60.0 g 6 o. o g リン酸 適 量 1,3-butylene glycol 10.0 g 10.0 g 1 0.0 g ethanol 60.0 g 60.0 g 6 o.og Phosphoric acid
水酸化ナ卜リウム 適 量 Sodium hydroxide
精製水 （全量） 10 OmL 10 OmL 1 0 OmL Purified water (total) 10 OmL 10 OmL 10 OmL
PH 7.0 9.1 6.5
PH 7.0 9.1 6.5
比较品 4 本発明品 50 本発明品 51 本発明品 52 本発明品 53 本発明品 54 本発明品 55 ミノキシジル 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 gComparative product 4 invention product 50 invention product 51 invention product 52 invention product 53 invention product 54 invention product 55 minoxidil 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g 1.0 g
L—メン! ^一レ 0.3 g L-men!
ビタミン Eァセテ一卜 0.08 g Vitamin E acetate 0.08 g
パン卜テニルェチルエーテル 1.0 g Pantothenyl ethyl ether 1.0 g
ヒノキチオール 0.05 g Hinokitiol 0.05 g
グリチルレチン酸 0.1 Glycyrrhetinic acid 0.1
塩酸ジフェンヒドラミン 0.1 oDiphenhydramine hydrochloride 0.1 o
1 , 3—ブチレングリコー Jレ 1 0.0 g ι ο. θε 1 0.0 g 1 0.0 g 1 0. Og 1 0.0 g 1 0.0 g エタノール 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g1, 3-butyleneglycol 10.0 g ιο.θε 1 0.0 g 1 0.0 g 1 0.Og 1 0.0 g 10.0 g ethanol 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g 60.0 g
\)ン酸 適 量 適 量 適 量 適 量 適 量 適 量 適 量 精製水 （全量） 1 0 OmL 1 0 OmL 1 0 OmL 1 0 Om L 1 0 OmL 1 0 OmL 1 0 Om L \) Acid acid qs qq qq qq qq qq.purified water (total) 10 OmL 1 0 OmL 1 0 OmL 1 0 Om L 1 0 OmL 1 0 OmL 10 OmL
PH 7.0 7.0 7.0 7.0 7.0 7.0 7.0
PH 7.0 7.0 7.0 7.0 7.0 7.0 7.0
評 価 項 目 Evaluation item
スコア ハリ ·コシ ツヤ しっとリ感 Score firmness, shine, moist feeling
1 八リ ■コシが悪い ツヤがあまり感じられない しっとり感があまり感じられない 1 Eighty ■ The stiffness is poor. The gloss is not felt much. The moist feeling is not felt much.
2 ノヽリ ·コシカ ίやや悪い ツヤがわずかに感じられる しっとリ感がわずかに感じられる2 Nori Koshika 悪 い Slightly shiny Slightly crisp
3 八リ■コシが普通 ツヤが感じられる しっとリ感が感じられる 3 Normally, you can feel a gloss.
4 ハリ ·コシがやや良い ツヤが良く感じられる しっとり感が良く感じられる 4 Slightly firm and firm Smooth feeling Good moist feeling
5 ハリ ·コシが良い ツヤが非常に良く感じられる しっとり感が非常に良く感じられる
5 Good firmness and luster Very glossy feeling Very moist feeling
1 週 間 後 3 週 間 後 八リ •コシ ツヤ しっとり感 ハリ ■コシ ツヤ しっと y感 本発明品 47 2 25 1. 75 2. 75 3 4 4 本発明品 48 2 5 2. 75 3 3 75 4 4 本発明品 49 3 2. 5 3. 75 3 5 4 4 本発明品 50 2. 25 25 2 1. 75 After 1 week After 3 weeks 8 リ • Koshi shiny Moist firmness ■ Koshi shiny Moist y sense Inventive product 47 2 25 1.75 2.75 3 4 4 Inventive product 48 2 5 2.75 3 3 75 4 4 Present product 49 3 2.5 3.75 3 5 4 4 Present product 50 2.25 25 2 1.75
11
本発明品 51 1. 75 75 2 1. 5 本発明品 52 1. 25 2. 75 25 2 1. 5 本発明品 53 1. 25 25 2 1. 75 本発明品 54 1 . 5 2 1. 5 本発明品 55 1. 25 . 25 2 1. 75 比铰品 4 2 . 25 1. 75 1. 25
Inventive product 51 1.75 75 21.5 Inventive product 52 1.25 2.75 25 21.5 Inventive product 53 1.25 25 2 1.75 Inventive product 54 1.5 .2 1.5 Present product 55 1.25.25 2 1.75 Comparative product 4 2.25 1.75 1.25
美しく健康な頭髪の重要な要素としてハリ · コシ、 ツヤ及びしっとり 感が挙げられる。 本発明の育毛ローションがこれらの要素に及ぼす影響 について、 3週間の使用感試験により判定した。 Important elements of beautiful and healthy hair include firmness, shine, and moistness. The effect of the hair growth lotion of the present invention on these factors was determined by a 3-week usability test.
その結果、 実施例の育毛ローションは、 比較例の育毛ローションに 比較し、 早い時期から高い効果が認められた。 さらに、 選択成分を複数 組合わせることによりこれまでにない使用感を得ることが見出された。 また、 使用感向上の効果は三つの要素の全てについてバランス良く得ら れており、 頭髪用剤として総合的に使用感を向上させる効果を有するこ とが判明した。 以 上
As a result, the hair growth lotion of the example showed a higher effect from an earlier stage than the hair growth lotion of the comparative example. Furthermore, it has been found that an unprecedented feeling of use is obtained by combining a plurality of selected components. In addition, the effect of improving the usability was obtained in a well-balanced manner for all three factors, and it was found that the composition had an overall effect of improving the usability as a hair preparation. that's all
Claims
1 . 1 〜 6質量％のミノキシジル、 多価アルコール、 エタノール及 び水を含み、 さらにメントール、 ビタミン Eアセテート、 パン卜テニル ェチルエーテル、 ヒノキチオール、 グリチルレチン酸および塩酸ジフエ ンヒ ドラミンから成る群より選ばれる成分の 1 種又は 2種以上を含有し てなる育毛組成物。 1.1. A component containing from 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol and water, and further selected from the group consisting of menthol, vitamin E acetate, pantothenyl ethyl ether, hinokitiol, glycyrrhetinic acid and diphenhydramine hydrochloride. A hair-growing composition comprising one or more kinds.
2 . 1 〜 6質量％のミノキシジル、 多価アルコール、 エタノール、 メントール及び水を含み、 さらにビタミン Eアセテート、 パン卜テニル ェチルエーテル、 ヒノキチオール、 グリチルレチン酸および塩酸ジフエ ンヒドラミンから成る群より選ばれる成分の 1 種又は 2種以上を含有し てなる育毛組成物。 2.1 One component selected from the group consisting of 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, menthol, and water, and further selected from the group consisting of vitamin E acetate, pantothenyl ethyl ether, hinokitiol, glycyrrhetinic acid, and diphenhydramine hydrochloride. Or, a hair-growing composition comprising two or more.
3 . 1 〜 6質量％のミノキシジル、 多価アルコール、 エタノール、 ビタミン Eアセテート及び水を含み、 さらにメントール、 パン卜テニル ェチルエーテル、 ヒノキチ才一ル、 グリチルレチン酸および塩酸ジフエ ンヒドラミンから成る群より選ばれる成分の 1 種又は 2種以上を含有し てなる育毛組成物。 3.1 An ingredient containing 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, vitamin E acetate and water, and further selected from the group consisting of menthol, pantothenyl ethyl ether, hinokiti, glycyrrhetinic acid and diphenhydramine hydrochloride. A hair restoration composition comprising one or more of the following.
4 . 1 〜 6質量％のミノキシジル、 多価アルコール、 エタノール、 パ ン卜テニルェチルエーテル及び水を含み、 さらにメントール、 ビタミン Eアセテート、 ヒノキチ才一ル、 グリチルレチン酸および塩酸ジフェン ヒドラミンから成る群より選ばれる成分の 1 種又は 2種以上を含有して なる育毛組成物。
4.1 1 to 6% by mass of minoxidil, polyhydric alcohol, ethanol, panthenyl ethyl ether and water, and from the group consisting of menthol, vitamin E acetate, hinokiti, glycyrrhetinic acid and diphen hydramine hydrochloride A hair growth composition comprising one or more selected components.
5 . 多価アルコールの配合量が 5 ~ 3 0質量％である請求項 1 〜 4 の何れかの項記載の育毛組成物。 5. The hair restoration composition according to any one of claims 1 to 4, wherein the blending amount of the polyhydric alcohol is 5 to 30% by mass.
6 . 水の配合量が 5〜 3 0質量％である請求項 1 〜 5の何れかの項 記載の育毛組成物。 6. The hair restoration composition according to any one of claims 1 to 5, wherein the amount of water is 5 to 30% by mass.
7 . ェタノールの配合量が 2 5 ~ 7 5質量％である請求項 1 〜 6の 何れかの項記載の育毛組成物。 7. The hair growth composition according to any one of claims 1 to 6, wherein the amount of the ethanol is 25 to 75% by mass.
8 . ミノキシジルの配合量が 2〜 6質量％である請求項 1 〜 7の何 れかの項記載の育毛組成物。 8. The hair restoration composition according to any one of claims 1 to 7, wherein the amount of minoxidil is 2 to 6% by mass.
9 . 組成物の p Hが 5 . 5〜 9 . 5である請求項 1 〜 8の何れかの項 記載の育毛組成物。 9. The hair restoration composition according to any one of claims 1 to 8, wherein the pH of the composition is 5.5 to 9.5.
1 0 . 実質的に界面活性剤を含有しない請求項 1 〜 9の何れかの項記 載の育毛組成物。 10. The hair growth composition according to any one of claims 1 to 9, wherein the hair growth composition is substantially free of a surfactant.
1 1 . 多価アルコールが 1 ， 3 —プチレングリコール、 グリセリン、 ジプロピレングリコール、 マクロゴール 3 0 0、 マクロゴール 4 0 0、 マクロゴール 6 0 0からなる群から選ばれたものである請求項 1 〜 1 0 の何れかの項記載の育毛組成物。 11. The polyhydric alcohol is selected from the group consisting of 1,3-butylene glycol, glycerin, dipropylene glycol, macrogol 300, macrogol 400, and macrogol 600. Item 10. The hair growth composition according to any one of Items 1 to 10.
1 2 . 多価アルコールが 1 ， 3—プチレングリコールである請求項 1 〜 1 0の何れかの項記載の育毛組成物。
12. The hair growth composition according to any one of claims 1 to 10, wherein the polyhydric alcohol is 1,3-butylene glycol.
1 3. 多価アルコールがグリセリンである請求項〗 〜 1 0の何れかの 項記載の育毛組成物。 1 3. The hair restoration composition according to any one of claims 1 to 10, wherein the polyhydric alcohol is glycerin.
1 4. 多価アルコールがジプロピレングリコールである請求項 1 〜 1 0の何れかの項記載の育毛組成物。 14. The hair restoration composition according to any one of claims 1 to 10, wherein the polyhydric alcohol is dipropylene glycol.
Ί 5. 多価アルコールがマク口ゴール 4 0 0である請求項 1 〜 1 0の 何れかの項記載の育毛組成物。 1 6. 多価アルコールがマクロゴール 6 0 0である請求項 1 〜 1 0の 何れかの項記載の育毛組成物。 Ί 5. The hair-growing composition according to any one of claims 1 to 10, wherein the polyhydric alcohol is McGoal 400. 16. The hair restoration composition according to any one of claims 1 to 10, wherein the polyhydric alcohol is macrogol 600.
1 7. 多価アルコールが 1 ， 3 —ブチレングリコール、 グリセリン、 ジプロピレングリコール、 マクロゴール 3 0 0、 マクロゴール 4 0 0、 マクロゴール 6 0 0からなる群から選ばれたものの 2種以上である請求 項 1 ~ 1 0の何れかの項記載の育毛組成物。 1 7. The polyhydric alcohol is one or more selected from the group consisting of 1,3-butylene glycol, glycerin, dipropylene glycol, macrogol 300, macrogol 400, macrogol 600 The hair growth composition according to any one of claims 1 to 10.
1 8. 更に p H調整剤として酸および/または塩基を配合した請求項 1 〜 1 7の何れかの項記載の育毛組成物。 18. The hair growth composition according to any one of claims 1 to 17, further comprising an acid and / or a base as a pH adjuster.
1 9. p H調整剤が、 クェン酸、 塩酸、 乳酸、 リン酸、 酒石酸または ダルコン酸である請求項 1 8項記載の育毛組成物。 19. The hair-growing composition according to claim 18, wherein the pH adjusting agent is cunic acid, hydrochloric acid, lactic acid, phosphoric acid, tartaric acid or dalconic acid.
2 0. 外用ローション剤である請求項 1 〜 1 9の何れかの項記載の育 毛組成物。
20. The hair growth composition according to any one of claims 1 to 19, which is an external lotion.
2 1 . 外用エアゾール剤である請求項 〜 1 9の何れかの項記載の育 毛組成物。 21. The hair growth composition according to any one of claims 19 to 19, which is an external aerosol.
2 2. ゲル剤である請求項 1 〜 1 9の何れかの項記載の育毛組成物。
2 2. The hair growth composition according to any one of claims 1 to 19, which is a gel.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001244729A AU2001244729A1 (en) | 2000-04-07 | 2001-04-05 | Hair growth stimulant compositions |
| JP2001574059A JPWO2001076540A1 (en) | 2000-04-07 | 2001-04-05 | Hair restoration composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000-106497 | 2000-04-07 | ||
| JP2000106497 | 2000-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001076540A1 true WO2001076540A1 (en) | 2001-10-18 |
Family
ID=18619655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2001/002940 WO2001076540A1 (en) | 2000-04-07 | 2001-04-05 | Hair growth stimulant compositions |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPWO2001076540A1 (en) |
| AU (1) | AU2001244729A1 (en) |
| WO (1) | WO2001076540A1 (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006342090A (en) * | 2005-06-08 | 2006-12-21 | Taisho Pharmaceut Co Ltd | Aerosol |
| ES2315115A1 (en) * | 2006-07-31 | 2009-03-16 | Jose Ignacio Navarro Sanchez | New capillary concentrate solution based on minoxidil. (Machine-translation by Google Translate, not legally binding) |
| JP2013056882A (en) * | 2012-09-28 | 2013-03-28 | Taisho Pharmaceutical Co Ltd | Aerosol agent |
| JP2016138094A (en) * | 2015-01-23 | 2016-08-04 | 大正製薬株式会社 | External composition |
| JP2016145179A (en) * | 2015-02-06 | 2016-08-12 | ダイヤ製薬株式会社 | Minoxidil-containing liquid medicine for external use, and manufacturing method of liquid medicine for external use |
| JP2020023467A (en) * | 2018-01-19 | 2020-02-13 | ロート製薬株式会社 | External preparation, method for improving liquid breaking properties, and agent for improving liquid breaking properties |
| JP2020105217A (en) * | 2015-03-27 | 2020-07-09 | 大正製薬株式会社 | Lotion |
| JP2021014416A (en) * | 2019-07-10 | 2021-02-12 | ロート製薬株式会社 | External preparation |
| JP2021165305A (en) * | 2016-09-15 | 2021-10-14 | 大正製薬株式会社 | Composition for external use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH054908A (en) * | 1990-09-28 | 1993-01-14 | Taisho Pharmaceut Co Ltd | Minoxidil-containing hair growth agent |
| JPH06211681A (en) * | 1993-01-12 | 1994-08-02 | Taisho Pharmaceut Co Ltd | Testosterone-5alpha-reductase inhibitor |
| JPH08277209A (en) * | 1995-04-07 | 1996-10-22 | Taisho Pharmaceut Co Ltd | Revitalizing hair tonic |
| JPH09188620A (en) * | 1996-01-05 | 1997-07-22 | Taisho Pharmaceut Co Ltd | Hinokitiol-containing composition |
| EP0970683A1 (en) * | 1997-01-23 | 2000-01-12 | Taisho Pharmaceutical Co. Ltd | Persistent hair tonic |
| JP2000198719A (en) * | 1998-10-29 | 2000-07-18 | Taisho Pharmaceut Co Ltd | Hair growing agent |
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2001
- 2001-04-05 AU AU2001244729A patent/AU2001244729A1/en not_active Abandoned
- 2001-04-05 WO PCT/JP2001/002940 patent/WO2001076540A1/en active Application Filing
- 2001-04-05 JP JP2001574059A patent/JPWO2001076540A1/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH054908A (en) * | 1990-09-28 | 1993-01-14 | Taisho Pharmaceut Co Ltd | Minoxidil-containing hair growth agent |
| JPH06211681A (en) * | 1993-01-12 | 1994-08-02 | Taisho Pharmaceut Co Ltd | Testosterone-5alpha-reductase inhibitor |
| JPH08277209A (en) * | 1995-04-07 | 1996-10-22 | Taisho Pharmaceut Co Ltd | Revitalizing hair tonic |
| JPH09188620A (en) * | 1996-01-05 | 1997-07-22 | Taisho Pharmaceut Co Ltd | Hinokitiol-containing composition |
| EP0970683A1 (en) * | 1997-01-23 | 2000-01-12 | Taisho Pharmaceutical Co. Ltd | Persistent hair tonic |
| JP2000198719A (en) * | 1998-10-29 | 2000-07-18 | Taisho Pharmaceut Co Ltd | Hair growing agent |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006342090A (en) * | 2005-06-08 | 2006-12-21 | Taisho Pharmaceut Co Ltd | Aerosol |
| ES2315115A1 (en) * | 2006-07-31 | 2009-03-16 | Jose Ignacio Navarro Sanchez | New capillary concentrate solution based on minoxidil. (Machine-translation by Google Translate, not legally binding) |
| JP2013056882A (en) * | 2012-09-28 | 2013-03-28 | Taisho Pharmaceutical Co Ltd | Aerosol agent |
| JP2016138094A (en) * | 2015-01-23 | 2016-08-04 | 大正製薬株式会社 | External composition |
| JP2016145179A (en) * | 2015-02-06 | 2016-08-12 | ダイヤ製薬株式会社 | Minoxidil-containing liquid medicine for external use, and manufacturing method of liquid medicine for external use |
| JP2020105217A (en) * | 2015-03-27 | 2020-07-09 | 大正製薬株式会社 | Lotion |
| JP7067581B2 (en) | 2015-03-27 | 2022-05-16 | 大正製薬株式会社 | Lotion |
| JP2021165305A (en) * | 2016-09-15 | 2021-10-14 | 大正製薬株式会社 | Composition for external use |
| JP7569019B2 (en) | 2016-09-15 | 2024-10-17 | 大正製薬株式会社 | External Composition |
| JP2020023467A (en) * | 2018-01-19 | 2020-02-13 | ロート製薬株式会社 | External preparation, method for improving liquid breaking properties, and agent for improving liquid breaking properties |
| JP2021014416A (en) * | 2019-07-10 | 2021-02-12 | ロート製薬株式会社 | External preparation |
| JP7488634B2 (en) | 2019-07-10 | 2024-05-22 | ロート製薬株式会社 | Topical preparations |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001244729A1 (en) | 2001-10-23 |
| JPWO2001076540A1 (en) | 2004-01-08 |
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