JP3205601B2 - Hair restorer - Google Patents
Hair restorerInfo
- Publication number
- JP3205601B2 JP3205601B2 JP20608992A JP20608992A JP3205601B2 JP 3205601 B2 JP3205601 B2 JP 3205601B2 JP 20608992 A JP20608992 A JP 20608992A JP 20608992 A JP20608992 A JP 20608992A JP 3205601 B2 JP3205601 B2 JP 3205601B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- present
- hair restorer
- theophylline
- restorer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【０００１】[0001]
【産業上の利用分野】本発明はテオフィリンを有効成分
として含有する育毛剤に関する。本発明における育毛剤
とは脱毛を防止し、発毛、育毛を促進し得る目的で利用
される。The present invention relates to a hair restorer containing theophylline as an active ingredient. The hair restorer in the present invention is used for the purpose of preventing hair loss and promoting hair growth and hair growth.
【０００２】[0002]
【従来の技術】従来、男性型脱毛症および円形脱毛症な
どの治療・改善を目的として、血行促進剤、細胞賦活
剤、ビタミン剤、抗男性ホルモン剤を有効成分とする育
毛剤が知られている。しかしながら、脱毛および発毛の
メカニズムについては未だ不明な点が多く、十分な治療
・改善効果は得られていない。2. Description of the Related Art Hitherto, for the purpose of treating and improving male pattern baldness and alopecia areata, a hair restorer containing a blood circulation promoter, a cell activator, a vitamin, and an antiandrogen has been known as an active ingredient. I have. However, there are still many unclear points about the mechanisms of hair loss and hair growth, and a sufficient therapeutic / improving effect has not been obtained.
【０００３】[0003]
【発明が解決しようとする課題】したがって、脱毛を防
止し、発毛、育毛を促進する有効成分の開発と、その育
毛剤への応用が望まれている。Therefore, there is a demand for the development of an active ingredient that prevents hair loss and promotes hair growth and hair growth, and its application to a hair growth agent.
【０００４】[0004]
【課題を解決するための手段】斯かる実情に鑑み、本発
明者は多くの天然物および化合物について育毛効果を検
討した結果、下記一般式（１）で表されるテオフィリン
に強い育毛効果を有することを見いだし、本発明を完成
するに至った。In view of such circumstances, the present inventors have studied the hair growth effect of many natural products and compounds and found that the theophylline represented by the following general formula (1) has a strong hair growth effect. This led to the completion of the present invention.
【化１】なお、本発明で用いられるテオフィリンは1、3-
ジメチルキサンチンであり、天然または合成されたもの
の何れでもよく、市販品を利用することができる。The theophylline used in the present invention is 1,3-
Dimethylxanthine, which may be natural or synthetic, may be a commercially available product.
【０００５】本発明に用いられるテオフィリンの全組成
中の配合量は、十分に効果の得られる範囲の検討から、
２〜１０重量％（以下単に％で示す）である。１０％を
越えると、その増加分に見合った効果の向上は望めな
い。また、本発明の育毛剤はテオフィリンの他に必要に
応じて、添加剤および育毛剤として慣用されている他の
薬剤を本発明の効果を損なわない範囲で適宜配合するこ
とができる。添加剤としては、例えば、ヒノキチオー
ル、塩化ベンザルコニウム、ヘキサクロロフェン、ウン
デシレン酸などの抗菌剤、メントールなどの清涼剤、高
級脂肪酸、高級アルコール類、界面活性剤、香料、酸化
防止剤、エタノール、精製水、保湿剤などが挙げられ
る。また、育毛剤として慣用されている他の薬剤として
は、例えば、センブリエキス、アセチルコリン誘導体な
どの血管拡張剤、スウェルチノーゲン、ビタミンＥニコ
チン酸エステル、トウガラシチンキ、朝鮮ニンジンを挙
げることができ、これらを１種または２種以上混合して
使用することができる。[0005] Total composition of theophylline used in the present invention
From the examination of the range in which the effect can be obtained sufficiently,
2 to 10% by weight (hereinafter simply indicated as%). 10%
Beyond that, the effect cannot be expected to increase in proportion to the increase
No. In addition, the hair restorer of the present invention may optionally contain, in addition to theophylline, additives and other agents commonly used as a hair restorer as long as the effects of the present invention are not impaired. Examples of additives include antibacterial agents such as hinokitiol, benzalkonium chloride, hexachlorophen, and undecylenic acid, cooling agents such as menthol, higher fatty acids, higher alcohols, surfactants, fragrances, antioxidants, ethanol, and purification. Water, humectants and the like can be mentioned. Other drugs commonly used as a hair restorer include, for example, assembly extract, vasodilators such as acetylcholine derivatives, swelltinogen, vitamin E nicotinic acid ester, pepper tincture, and Korean ginseng. May be used alone or in combination of two or more.
【０００６】本発明の育毛剤は、外用剤として用いられ
るものであればその剤型については制限されるものでは
なく、例えば、ヘアトニック、ヘアローション、ヘアク
リーム、エアゾール、シャンプー、リンスなどが挙げら
れる。[0006] The form of the hair restorer of the present invention is not limited as long as it is used as an external preparation, and examples thereof include hair tonic, hair lotion, hair cream, aerosol, shampoo, and rinse. Can be
【０００７】[0007]
【実施例】つぎに、代表的な実施例によって本発明にお
ける育毛剤の製剤化方法を具体的に挙げるが、本発明は
これに限定されるものではない。EXAMPLES Next, the method of formulating a hair restorer according to the present invention will be specifically described with reference to typical examples, but the present invention is not limited thereto.
【０００８】実施例−１ ヘアトニック １．９５％エタノール ６０．０部 ２．テオフィリン ２．０ ３．グリセリン ２．０ ４．精製水 ３６．０ ［製法］テオフィリンをエタノールに懸濁し、グリセリ
ン、精製水を加え、十分撹拌混合し、ヘアトニックとす
る。[0008] Example - 1 Hair tonic 1.95% ethanol 60.0 parts of 2. Theophylline 2.0 3. Glycerin 2.0 4. Purified water 36.0 [Production method] Theophylline is suspended in ethanol, glycerin and purified water are added, and the mixture is sufficiently stirred and mixed to obtain a hair tonic.
【０００９】[0009]
【００１０】[0010]
【００１１】[0011]
【発明の効果】本発明の育毛剤は、優れた育毛効果を有
し、男性型脱毛症および老人性脱毛症を含む多くの脱毛
症に有効なものである。The hair restorer of the present invention has an excellent hair restorer effect and is effective for many alopecias including androgenetic alopecia and senile alopecia.
【００１２】[0012]
【実験例】つぎに、本発明の効果を詳細に説明するた
め、実験例を挙げる。 実験例−１ マウスに対する育毛効果 3週齢ICR系雄性マウスの背部毛を皮膚に損傷を与えない
ように注意深く毛刈および剃毛し、これらのマウスを12
匹ずつ2群に分け、1群にテオフィリンを2%含有する80%
エタノール溶液を、またもう1群には対照としての80%エ
タノール溶液を1日2回、1回につき約0.5mlそれぞれ塗布
した。判定は剃毛部における再生毛の認められた面積を
測定することにより行い、下記の式に従って再生率を算
出した。 EXPERIMENTAL EXAMPLES Next, experimental examples will be described in order to explain the effects of the present invention in detail. Experimental Example 1 Hair-growth effect on mice The back hairs of 3-week-old ICR male mice were carefully shaved and shaved so as not to damage the skin.
80% containing 2% theophylline in one group
The ethanol solution was applied to the other group, and an 80% ethanol solution as a control was applied to the other group twice a day, about 0.5 ml each time. The judgment was made by measuring the area of the shaved part where the regenerated hair was recognized, and the renewal rate was calculated according to the following equation.
【００１３】[0013]
【表１】 試料塗布開始後、23日目、26日目、29日目、32日目およ
び35日目の各群における再生率を求めた結果を表１に示
したが、テオフィリンは対照と比較した場合、毛の再生
を明らかに速め、顕著な発毛促進効果が認められた。[Table 1] After the start of the sample application, the results of determining the regeneration rate in each group on day 23, day 26, day 29, day 32 and day 35 are shown in Table 1, where theophylline was compared with the control. Hair regeneration was clearly accelerated, and a remarkable hair growth promoting effect was observed.
【００１４】実験例−２ ヒトに対する育毛効果 脱毛に悩む男性１５人に対し、実施例−１のヘアトニッ
クを３ヶ月間毎日１回塗布の使用テストを実施したとこ
ろ、７人に有効、６人にやや有効の結果が得られ、かつ
皮膚に異常は見られなかった。本発明の育毛剤には人に
対しても有効であり、かつ皮膚刺激のないことを確認し
た。[0014] On the other 15 men suffering from hair-growth effect of hair removal for Experimental Example -2 person, Example - was carried out using test of one of the hair tonic for three months applied once a day, effective in 7 people, 6 people Slightly effective results were obtained, and no abnormality was found on the skin. It was confirmed that the hair restorer of the present invention is effective for humans and has no skin irritation.
フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/06 - 7/155 Continuation of the front page (58) Field surveyed (Int.Cl. 7 , DB name) A61K 7 /06-7/155
Claims (1)
とを特徴とする育毛剤。(1) Theophylline is contained in an amount of 2 to 10% by weight.
And a hair restorer characterized by the following .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20608992A JP3205601B2 (en) | 1992-07-09 | 1992-07-09 | Hair restorer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20608992A JP3205601B2 (en) | 1992-07-09 | 1992-07-09 | Hair restorer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0624943A JPH0624943A (en) | 1994-02-01 |
| JP3205601B2 true JP3205601B2 (en) | 2001-09-04 |
Family
ID=16517635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20608992A Expired - Lifetime JP3205601B2 (en) | 1992-07-09 | 1992-07-09 | Hair restorer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3205601B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2898048B1 (en) * | 2006-03-01 | 2008-05-30 | Oreal | COSMETIC USE OF THEOPHYLLINE N-OXIDE DERIVATIVE |
| US20080059313A1 (en) * | 2006-08-30 | 2008-03-06 | Oblong John E | Hair care compositions, methods, and articles of commerce that can increase the appearance of thicker and fuller hair |
| DE102006042231A1 (en) * | 2006-09-06 | 2008-03-27 | Henkel Kgaa | Agent containing biochinones and purine or purine derivatives |
| DE102007013143A1 (en) * | 2007-03-15 | 2008-10-02 | Henkel Ag & Co. Kgaa | Use of purine and purine derivatives for hair treatment |
-
1992
- 1992-07-09 JP JP20608992A patent/JP3205601B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0624943A (en) | 1994-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |