JPH1025226A - Hair growing and restoring agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair growing and restoring agent having excellent hair restoring activity against various alopecias irrespective of symptoms or an individual difference by using specific polyprenyl alcohols. SOLUTION: This hair growing and restoring agent contains one or more than two kinds of polyprenyl alcohols expressed by the formula (n) is an integer of 1-4}. Geranylgeraniol having (n) of 2 in the polyprenyl alcohols of the formula is especially preferable. Preferably, a mixing amount of the polyprenyl alcohol of the formula is 0.01-10wt.%, especially 0.1-5wt.% based on the whole agent. Although the hair growing and restoring agent is useful when singly used, other component such as a promotor of circulation of the blood, an antibacterial agent, a keratolysis agent, an antiseborrheic agent, a local stimulating agent, an antiinflammatory agent, an antiandrogen agent or a hair follicle activating agent may further be combinedly used for the purpose of increasing the hair restoring effect.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restoration / hair restoration material, and more particularly to a hair restoration / hair restoration material having excellent hair restoration activity against many alopecia irrespective of symptoms and individual differences.

[0002]

2. Description of the Related Art Alopecia such as male pattern baldness, alopecia areata, etc., the mechanism and details of its onset are still unknown. Conventionally,
Empirically, natural extracts, blood circulation enhancers,
Immunosuppressants, metabolic accelerators, vitamins, antiandrogens, and the like have been used. However, these drugs are not only ineffective in many cases depending on symptoms or individuals, but their effects are not satisfactory.

[0003]

Therefore, there has been a demand for the development of a hair restoration / hair restoration material having excellent hair restoration activity against many alopecia irrespective of symptoms and individual differences.

[0004]

Means for Solving the Problems The present inventors have made intensive studies in view of the above circumstances, and as a result, have found that specific polyprenyl alcohols can be effectively prevented against many alopecia irrespective of symptoms and individual differences. They have found that they have a therapeutic effect, and have completed the present invention.

That is, the present invention provides a compound represented by the general formula (1):

[0006]

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[0007] It is an object of the present invention to provide a hair restorer or hair restorer comprising one or more polyprenyl alcohols represented by the formula: wherein n is an integer of 1 to 4.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The polyprenyl alcohol represented by the general formula (1) used in the present invention is a known one. Among them, geraniol represented by the general formula (1) and n = 1 is used as a fragrance. And
Geranylgeraniol represented by n = 2 in the general formula (1) is known to have apoptosis-inducing ability on leukemia anemia cells HL-60 [J. Biochem.
171, 11-13 (1995)], and its hair-growth and hair-growth activities are not known.

In the general formula (1), n represents an integer of 1 to 4, preferably 1 or 2, and particularly preferably 2.

Specific examples of the polyprenyl alcohol represented by the general formula (1) include geraniol, geranylgeraniol, and farnesyl farnesol.
Geranylgeraniol is particularly preferred.

Such polyprenyl alcohols can be used singly or in combination of two or more. The amount of the polyprenyl alcohol is not particularly limited, but from the viewpoint of the efficacy and the feeling of use, the hair growth and hair growth of the present invention can be used. 0.01 to 1 in the charge
It is preferably 0% by weight, particularly preferably 0.1 to 5% by weight.

In the present invention, the polyprenyl alcohol (1) may be of natural origin or of synthetic origin.

The above-mentioned polyprenyl alcohol (1) may be used alone without using other components. However, in order to further enhance the hair growth effect, a blood circulation promoter, an antibacterial agent, a keratolytic agent, an anti-keratolytic agent, and the like. Seborrheic, local irritant, anti-inflammatory, humectant,
It may be used in combination with other components such as an antiandrogen and a hair follicle activator.

Among these components, the blood circulation promoting agents include acetylcholine, assembly extract, carrot extract, ginkgo extract, carpronium chloride, diphenhydramine hydrochloride, γ-oryzanol, circretin, cromakalim, cepharanthin, nicorandil, vitamin E, vitamin E nicotinate And the like, pinacidyl, minoxidil, phthalides, kina extract, shobu root extract, spruce extract, this drug extract, yuzu extract and the like. Among them, acetylcholine, assembly extract, carrot extract, ginkgo extract, vitamin E and its derivatives, cepharanthin, minoxidil, carpronium chloride, diphenhydramine hydrochloride, γ-oryzanol, circretin, cromakalim, cepharanthin, nicorandil, pinacidil, minoxidil, phthalides, kina extract , Shobu root extract, spruce extract,
This drug extract and yuzu extract are preferable, and particularly, assembly extract, carrot extract, ginkgo extract, vitamin E and its derivatives, cepharanthin, minoxidil, carpronium chloride, and phthalides are preferable.

Examples of the antibacterial agent include isopropylmethylphenol, benzalkonium chloride, octopirox, photosensitive dye 101, photosensitive dye 201, chlorhexidine, salicylic acid, zinc pyrithione, potassium sorbate, biosol, hinokitiol, and phenol. Examples of the topical stimulant include camphor, l-menthol, nonylate vanillylamide, tincture tincture,
Examples include Dutch mustard extract, cantaris tincture, salamander extract, peppermint oil, wasabi radish extract and the like.
Of these, octopirox, benzalkonium chloride,
Zinc pyrithione, salicylic acid and isopropylmethylphenol are preferred.

Examples of the keratolytic agent include aspirin and the like. Antiseborrheic agents include sulfur, thioxolone, banside, polysorbates, lecithin, cashew extract and the like.

Examples of the anti-inflammatory agent include azulene, guaiazulene, antihistamines (such as diphenhydramine), hydrocortisone acetate, prednisolone, ougon extract, chamomile extract, sagebrush extract, fennel extract, kyounin extract, gardenia extract, kumazasa extract, gentian extract, konjiana extract Free extract, hawthorn extract, birch extract, Yarrow extract,
Gentle oil extract, Tonin extract, peach leaf extract, loquat leaf extract and the like.

Examples of humectants include Hypericum, soluble collagen, glycerin, chondroitin sulfate, tuberose polysaccharide, cordyceps, trisaccharide, urea, biohyaluronic acid, hyaluronic acid, calcium vitamin C vitamin phosphate, sodium pyrrolidone carboxylate, propylene Glycol, prolonged life extract,
Barley extract, orange extract, seaweed extract, cucumber extract, burdock extract, shiitake extract, syrup extract, duke extract, loquat extract, grape leaf extract, prune extract, loofah extract, Maikai extract,
Mini Sasanishiki, lily extract, apple extract and the like can be mentioned.

Examples of the antiandrogen include ethinyl estradiol, chlormadinone acetate and the like.

As the hair follicle activator, N-acetyl-L-
Methionine, disodium adenosine triphosphate, potassium aspartate, photosensitive dye 301, pentadecanoic acid glyceride, netacanal, ethyl pantothenate, panthenol, biotin, mononitroguaiacol sodium, yeast extract, pearl protein extract, daisy extract, chik Ginseng, garlic components, placenta extract, royal jelly extract and the like.

The above-mentioned other components are preferably used alone or as a mixture of two or more, and are preferably used after being dissolved in water or a solvent such as water-lower alcohol.

From the viewpoint of synergistic effect with polyprenyl alcohol and irritation to the scalp, the above other components are contained in the hair growth and restoration product of the present invention in an amount of 0.001 to 10% by weight, especially 0.1 to 10% by weight.
It is preferred that the content be from 01 to 5 wt%.

The hair-growing / hair-growing agent of the present invention is used as an external preparation, and its dosage form is mainly liquid and lotion is typical, but it can be cream or gel. It is particularly preferable that the liquid preparation further contain carbon dioxide gas.

Carbon dioxide gas is the pH of the solution in which it is dissolved.
It is known that when is acidic, it exists as a CO ₂ molecule and exhibits a vasodilator effect. Therefore, the liquidity of the hair growth and fostering composition of the present invention containing carbon dioxide is pH 7 or less, especially pH
It is preferable to adjust to 4.5 to 6.5. In addition, hair growth
The pH of the hair restorer is such that carbon dioxide gas is injected into the hair restorer and the acidity further increases when the carbon dioxide gas dissolves into the hair restorer / hair restorer. The pH may be adjusted so that the final pH falls within the above range. As the pH adjuster, for example, organic acids such as citric acid, tartaric acid, and lactic acid or salts thereof, or phosphoric acid or salts thereof are suitably used.

In order to incorporate carbon dioxide into the hair growth and hair growth material of the present invention, other components except carbon dioxide are put into a pressure-resistant container, and high-pressure carbon dioxide is sealed therein. A method of adding a component that generates carbon dioxide gas containing carbonate and adding a pH adjusting agent to the mixture to generate carbon dioxide gas and sealing immediately, or a method of sealing by placing dry ice pellets in a container, etc. Although it is adopted, a method of sealing high-pressure carbon dioxide gas is particularly preferable.

In this case, a part of the carbon dioxide gas is dissolved and blended in the hair growth and fostering material of the present invention, and a part thereof is present as a gas in the container. In the present invention, it is important that the carbon dioxide gas is dissolved and compounded in the hair growth and hair growth material, and the compounding amount is preferably a carbon dioxide gas concentration of 60 ppm or more. Cannot be obtained. The amount of carbon dioxide gas can be adjusted by adjusting the amount of carbon dioxide gas injected (press-fitted). In general, the pressure in the vessel is 35 ° C. and 1.2 to 8 kg / cm ^2.
(Gauge pressure).

In addition to the above-mentioned components, the hair-growing / hair-growing agent of the present invention may contain, if necessary, an oily base, a gelling agent, and various kinds of oils used in ordinary cosmetics as long as the effects of the present invention are not impaired. Emulsifiers, fragrances, antioxidants such as parahydroxybenzoic acid esters, and coloring agents such as dyes can be added and blended. Specifically, distilled water, lower alcohols such as ethanol, higher alcohols such as cetanol, and propylene Examples include polyhydric alcohols such as glycol, vaseline, silicone, and surfactant.

The hair-growing / hair-growing agent of the present invention can be produced by subjecting the above essential components and optional components to operations such as mixing according to a conventional method.

[0029]

EFFECTS OF THE INVENTION The hair-growing / hair-growing agent of the present invention has excellent hair-growth activity against many alopecia irrespective of symptoms and individual differences.

[0030]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

Example 1 Hair Restoration Test 1 Dorsal hairs of 7-week-old C3H male mice in resting period were shaved over 2 × 4 cm ² using an electric clipper and then an electric razor so as not to damage the skin. Each group consisted of 20 mice. Geranylgeraniol and farnesol were each dissolved in a 70% aqueous ethanol solution (concentration: 100 mg / ml).
Once a day, 20 μl was applied to the shaved site. In order to observe the state of hair regeneration, a photograph of the shaved area was taken at a fixed magnification, and the area of the regenerated hair area (regenerated hair area /
Shaving area) was calculated, and the hair growth activity was determined. The case where only the solvent was applied was set as a control group. Table 1 shows the daily hair growth activity (%) after the start of sample application.

[0032]

[Table 1]

As is clear from Table 1, the hair growth activity of geranylgeraniol was extremely high. Further, farnesol showed only the same regenerated hair area ratio as the control group.

Example 2 Hair restoration test 2 In the same manner as in Example 1, geraniol and farnesol were each dissolved in a 70% aqueous ethanol solution (concentration: 1).
(00 mg / ml). Geraniol showed significant hair growth activity as compared to farnesol and the control group.

Example 3 Hair Growth Test 3 Geranylgeraniol was dissolved in a 70% ethanol aqueous solution in the same manner as in Example 1 (concentration: 100 mg / ml).
And the hair growth activity of minoxidil dissolved in a 70% ethanol solution (concentration: 300 mg / ml). Table 2 shows the results.

[0036]

[Table 2]

As is evident from Table 2, geranylgeraniol exhibited higher hair growth activity at a lower concentration than minoxidil, which has been conventionally used as a hair restorer and hair restorer.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Kimihiko Hori 2606 Akabane, Kaigamachi, Haga-gun, Tochigi Pref.

Claims (3)

[Claims] 1. General formula (1): A hair-growing / hair-growing agent comprising one or more polyprenyl alcohols represented by the formula: wherein n represents an integer of 1 to 4. 2. The hair restorer / hair restorer according to claim 1, wherein n is 2 in the general formula (1). 3. The hair restorer / hair restorer according to claim 1, which comprises 0.01 to 10% by weight of the polyprenyl alcohol represented by the general formula (1).