ES2315115A1

ES2315115A1 - New capillary concentrate solution based on minoxidil. (Machine-translation by Google Translate, not legally binding)

Info

Publication number: ES2315115A1
Application number: ES200602140A
Authority: ES
Inventors: Ignacio Navarro Sanchez
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-07-31
Filing date: 2006-07-31
Publication date: 2009-03-16
Anticipated expiration: 2026-07-31
Also published as: ES2315115B1

Abstract

Concentrated solution of 20% minoxidil. It consists of a solution in which minoxidil is in a concentration of 20% by weight, glycerin, sulfur-containing amino acid ethanol and a sufficient amount of lactic acid to obtain the recommended ph, are the rest of its components. It is used for the instantaneous preparation of any dilution (2, 5, and 10%) etc. By means of a hydroalcoholic solution (glycerol, ethanol and water) obtaining directly the appropriate capillary lotion in each case extemporaneously and instantaneously. (Machine-translation by Google Translate, not legally binding)

Description

Nueva solución capilar concentrada a base de minoxidil.New concentrated hair solution based on minoxidil

La presente invención se refiere a una solución concentrada de minoxidil, se encuadra en el sector técnico de cosmética, para la preparación extemporánea e instantánea de lociones, para tratamientos de la alopecia masculina frontoparietal y parietooccipital y alopecia femenina difusa, a la concentración requerida (2, 5 10% etc.). cuyas mejoras afectan al tiempo de espera por parte del paciente para obtener la loción necesitada.The present invention relates to a solution concentrated minoxidil, falls within the technical sector of cosmetic, for the extemporaneous and instantaneous preparation of lotions, for treatments of male frontoparietal alopecia and diffuse parietooccipital and female alopecia, at the concentration required (2, 5 10% etc.). whose improvements affect the time of wait for the patient to get the lotion needed

Background of the invention

Son numerosas las lociones capilares donde el principio activo o uno de ellos es el monoxidil encontrándose en concentraciones bajas (no superior al 10%) así como procesos para estimular el crecimiento del cabello.There are numerous hair lotions where the active substance or one of them is monoxidil found in low concentrations (not exceeding 10%) as well as processes for Stimulate hair growth.

Uno de los aspectos mas estudiados sobre el minoxidil o (3-oxido de 6-piperidino-2,4-diaminopirimidin) es su baja solubilidad en agua y, por lo tanto, la dificultad de disolución del producto con el consiguiente aumento de tiempo y medios para ello además de su bajo poder de penetración cutáneo, En general para disolver el minoxidil se utiliza una mezcla que contiene alcohol y propilenglicol. En la invención se utiliza glicerina que es menos irritante que el propilenglicol. Pero para casos donde la concentración de minoxildil sea alta, es recomendable la adición de un ácido (fórmico, acético, undecilenico y láctico).One of the most studied aspects about minoxidil or (3-oxide of 6-piperidino-2,4-diaminopyrimidin) is its low water solubility and, therefore, the difficulty of dissolution of the product with the consequent increase in time and means for this in addition to its low skin penetration power, in In general, to dissolve minoxidil, a mixture is used that Contains alcohol and propylene glycol. In the invention it is used Glycerin that is less irritating than propylene glycol. But for cases where the concentration of minoxildil is high, is The addition of an acid (formic, acetic, undecylene) is recommended and lactic).

Al realizar al búsqueda para el minoxidil con ácido láctico en la oficina española de Patentes y Marcas no encontramos ninguna patente, solo en la Worldwide database encontramos dos patentes japonesas (JP10279437, JP9188620) pero en ningún caso utilizando una concentración tan alta de minoxidil y ninguna con la adición de un aminoácido azufrado como el caso de la cisteina.When performing the search for minoxidil with lactic acid in the Spanish Patent and Trademark Office not We found no patent, only in the Worldwide database we found two Japanese patents (JP10279437, JP9188620) but in no case using such a high concentration of minoxidil and none with the addition of a sulfur amino acid as the case of the cysteine

Description of the invention

La presente invención se refiere a una nueva solución concentrada a base de minoxidil para que el farmacéutico o personal técnico pueda dispensar in situ al usuario o paciente la loción capilar requerida.The present invention to a new concentrated minoxidil solution based relates to the pharmaceutical or technical personnel to be dispensed in situ user or patient the required hair lotion.

La solución concentrada consiste en los siguientes ingredientes:The concentrated solution consists of following ingredients:

\bullet?: 18-22% en peso de Minoxidil 18-22% by weight from Minoxidil

\bullet?: 1-2% de aminoácido Cisteina 1-2% of amino acid cysteine

\bullet?: 15.30% en peso de Glicerina 15.30% by weight of Glycerin

\bullet?: 8-10% en peso de ácido Láctico 8-10% by weight lactic acid

\bullet?: c.s.p. 100% de Etanol c.s.p. 100% Ethanol

Para obtener la loción capilar se diluye la invención con una solución hidroalcoholica (glicerol 20%, etanol 60% y agua desionizada csp 100 ml).To obtain the hair lotion, dilute the invention with a hydroalcoholic solution (20% glycerol, ethanol 60% and deionized water csp 100 ml).

Gracias al ácido láctico se impide que cristalice el minoxidil, no obstante se recomienda conservarlo en recipientes color topacio cerrados herméticamente y a 15-30º temperatura ambiental. Muestra su mayor estabilidad a pH 5.0. Esta comprobado que al utilización de ácido láctico incrementa su poder de penetración cutáneo. Al utilizar glicerina en vez de propilenglicol se consigue un aspecto del cabello menos graso y de aspecto más estético.Thanks to lactic acid, it prevents crystallize minoxidil, however it is recommended to keep it in hermetically sealed topaz containers 15-30º ambient temperature. Show your biggest pH 5.0 stability. It is proven that the use of acid Lactic increases its skin penetration power. When using glycerin instead of propylene glycol you get an aspect of less oily hair and more aesthetic appearance.

La Cisteina aporta un nutriente necesario para el cabello, ya que a partir de esta el organismo puede sintetizar taurina, aminoácido no esencial que se acumula en el cabello donde juega un papel protector.Cysteine provides a necessary nutrient for the hair, since from this the organism can synthesize taurine, non-essential amino acid that accumulates in the hair where It plays a protective role.

Preparation Mode

Calentar a 55ºC la glicerina (20 g), una vez alcanzada dicha temperatura se añade el aminoácido azufrado (1 g) y el minoxidil (20 g). Se mezcla y agita bien hasta obtener una mezcla homogénea. Posteriormente, adicionamos el etanol 96º cosmético (49,7 g) y mantenemos la temperatura a 40ºC, inicialmente la mezcla es una solución blanca opaca, la cual se convierte en totalmente transparente una vez que ajustemos el pH a 5,3-5,5 con ácido láctico (9,3 g). La solución final tiene un suave color ámbar.Heat the glycerin (20 g) at 55 ° C once reached said temperature the sulfur amino acid (1 g) is added and the minoxidil (20 g). Mix and stir well until you get a homogeneous mixture. Subsequently, we add 96º ethanol cosmetic (49.7 g) and keep the temperature at 40 ° C, initially the mixture is an opaque white solution, which becomes fully transparent once we adjust the pH to 5.3-5.5 with lactic acid (9.3 g). The solution Finish has a soft amber color.

Claims

1. Concentrated preparation based on minoxidil without propylene glycol and with glycerin, without waiting times, for an extemporaneous and instantaneous preparation of hair lotions with an adequate concentration of minoxidil in each case (2%, 5%, 10% etc.) solution concentrated characterized by:

\bullet?: 18-22% en peso de Minoxidil 18-22% by weight from Minoxidil

\bullet?: 1-2% de aminoácido Cisteína 1-2% of amino acid cysteine

\bullet?: 15.30% en peso de Glicerina 15.30% by weight of Glycerin

\bullet?: 8-10% en peso de ácido Láctico 8-10% by weight lactic acid

\bullet?: c.s.p. 100% de Etanol c.s.p. 100% Ethanol

2. Preparations according to claim 1, characterized in that they are diluted with 20% glycerol, 60% ethanol and 100 ml deionized water hydrochloric solution to obtain diluted preparations of minoxidil in different proportions, 2, 5, 7 and 10% by varying the additives for pH control. The dilution is done extemporaneously and instantly.