ES2315115A1 - New capillary concentrate solution based on minoxidil. (Machine-translation by Google Translate, not legally binding) - Google Patents
New capillary concentrate solution based on minoxidil. (Machine-translation by Google Translate, not legally binding) Download PDFInfo
- Publication number
- ES2315115A1 ES2315115A1 ES200602140A ES200602140A ES2315115A1 ES 2315115 A1 ES2315115 A1 ES 2315115A1 ES 200602140 A ES200602140 A ES 200602140A ES 200602140 A ES200602140 A ES 200602140A ES 2315115 A1 ES2315115 A1 ES 2315115A1
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- ES
- Spain
- Prior art keywords
- minoxidil
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- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 229960003632 minoxidil Drugs 0.000 title claims abstract description 17
- 239000012141 concentrate Substances 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- 239000006210 lotion Substances 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 6
- 239000004310 lactic acid Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 150000001413 amino acids Chemical class 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims abstract 5
- 239000012895 dilution Substances 0.000 claims abstract 2
- 238000010790 dilution Methods 0.000 claims abstract 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 235000001014 amino acid Nutrition 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 abstract description 3
- 239000011593 sulfur Substances 0.000 abstract description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 3
- -1 undecylene Chemical group 0.000 description 3
- 201000004384 Alopecia Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 description 1
- IPFIEHIRBSTAKA-UHFFFAOYSA-N 6-piperidin-1-ylpyrimidine-2,4-diamine Chemical compound NC1=NC(N)=CC(N2CCCCC2)=N1 IPFIEHIRBSTAKA-UHFFFAOYSA-N 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000011031 topaz Substances 0.000 description 1
- 229910052853 topaz Inorganic materials 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Nueva solución capilar concentrada a base de minoxidil.New concentrated hair solution based on minoxidil
La presente invención se refiere a una solución concentrada de minoxidil, se encuadra en el sector técnico de cosmética, para la preparación extemporánea e instantánea de lociones, para tratamientos de la alopecia masculina frontoparietal y parietooccipital y alopecia femenina difusa, a la concentración requerida (2, 5 10% etc.). cuyas mejoras afectan al tiempo de espera por parte del paciente para obtener la loción necesitada.The present invention relates to a solution concentrated minoxidil, falls within the technical sector of cosmetic, for the extemporaneous and instantaneous preparation of lotions, for treatments of male frontoparietal alopecia and diffuse parietooccipital and female alopecia, at the concentration required (2, 5 10% etc.). whose improvements affect the time of wait for the patient to get the lotion needed
Son numerosas las lociones capilares donde el principio activo o uno de ellos es el monoxidil encontrándose en concentraciones bajas (no superior al 10%) así como procesos para estimular el crecimiento del cabello.There are numerous hair lotions where the active substance or one of them is monoxidil found in low concentrations (not exceeding 10%) as well as processes for Stimulate hair growth.
Uno de los aspectos mas estudiados sobre el minoxidil o (3-oxido de 6-piperidino-2,4-diaminopirimidin) es su baja solubilidad en agua y, por lo tanto, la dificultad de disolución del producto con el consiguiente aumento de tiempo y medios para ello además de su bajo poder de penetración cutáneo, En general para disolver el minoxidil se utiliza una mezcla que contiene alcohol y propilenglicol. En la invención se utiliza glicerina que es menos irritante que el propilenglicol. Pero para casos donde la concentración de minoxildil sea alta, es recomendable la adición de un ácido (fórmico, acético, undecilenico y láctico).One of the most studied aspects about minoxidil or (3-oxide of 6-piperidino-2,4-diaminopyrimidin) is its low water solubility and, therefore, the difficulty of dissolution of the product with the consequent increase in time and means for this in addition to its low skin penetration power, in In general, to dissolve minoxidil, a mixture is used that Contains alcohol and propylene glycol. In the invention it is used Glycerin that is less irritating than propylene glycol. But for cases where the concentration of minoxildil is high, is The addition of an acid (formic, acetic, undecylene) is recommended and lactic).
Al realizar al búsqueda para el minoxidil con ácido láctico en la oficina española de Patentes y Marcas no encontramos ninguna patente, solo en la Worldwide database encontramos dos patentes japonesas (JP10279437, JP9188620) pero en ningún caso utilizando una concentración tan alta de minoxidil y ninguna con la adición de un aminoácido azufrado como el caso de la cisteina.When performing the search for minoxidil with lactic acid in the Spanish Patent and Trademark Office not We found no patent, only in the Worldwide database we found two Japanese patents (JP10279437, JP9188620) but in no case using such a high concentration of minoxidil and none with the addition of a sulfur amino acid as the case of the cysteine
La presente invención se refiere a una nueva solución concentrada a base de minoxidil para que el farmacéutico o personal técnico pueda dispensar in situ al usuario o paciente la loción capilar requerida.The present invention to a new concentrated minoxidil solution based relates to the pharmaceutical or technical personnel to be dispensed in situ user or patient the required hair lotion.
La solución concentrada consiste en los siguientes ingredientes:The concentrated solution consists of following ingredients:
- \bullet?
- 18-22% en peso de Minoxidil 18-22% by weight from Minoxidil
- \bullet?
- 1-2% de aminoácido Cisteina 1-2% of amino acid cysteine
- \bullet?
- 15.30% en peso de Glicerina 15.30% by weight of Glycerin
- \bullet?
- 8-10% en peso de ácido Láctico 8-10% by weight lactic acid
- \bullet?
- c.s.p. 100% de Etanol c.s.p. 100% Ethanol
Para obtener la loción capilar se diluye la invención con una solución hidroalcoholica (glicerol 20%, etanol 60% y agua desionizada csp 100 ml).To obtain the hair lotion, dilute the invention with a hydroalcoholic solution (20% glycerol, ethanol 60% and deionized water csp 100 ml).
Gracias al ácido láctico se impide que cristalice el minoxidil, no obstante se recomienda conservarlo en recipientes color topacio cerrados herméticamente y a 15-30º temperatura ambiental. Muestra su mayor estabilidad a pH 5.0. Esta comprobado que al utilización de ácido láctico incrementa su poder de penetración cutáneo. Al utilizar glicerina en vez de propilenglicol se consigue un aspecto del cabello menos graso y de aspecto más estético.Thanks to lactic acid, it prevents crystallize minoxidil, however it is recommended to keep it in hermetically sealed topaz containers 15-30º ambient temperature. Show your biggest pH 5.0 stability. It is proven that the use of acid Lactic increases its skin penetration power. When using glycerin instead of propylene glycol you get an aspect of less oily hair and more aesthetic appearance.
La Cisteina aporta un nutriente necesario para el cabello, ya que a partir de esta el organismo puede sintetizar taurina, aminoácido no esencial que se acumula en el cabello donde juega un papel protector.Cysteine provides a necessary nutrient for the hair, since from this the organism can synthesize taurine, non-essential amino acid that accumulates in the hair where It plays a protective role.
Calentar a 55ºC la glicerina (20 g), una vez alcanzada dicha temperatura se añade el aminoácido azufrado (1 g) y el minoxidil (20 g). Se mezcla y agita bien hasta obtener una mezcla homogénea. Posteriormente, adicionamos el etanol 96º cosmético (49,7 g) y mantenemos la temperatura a 40ºC, inicialmente la mezcla es una solución blanca opaca, la cual se convierte en totalmente transparente una vez que ajustemos el pH a 5,3-5,5 con ácido láctico (9,3 g). La solución final tiene un suave color ámbar.Heat the glycerin (20 g) at 55 ° C once reached said temperature the sulfur amino acid (1 g) is added and the minoxidil (20 g). Mix and stir well until you get a homogeneous mixture. Subsequently, we add 96º ethanol cosmetic (49.7 g) and keep the temperature at 40 ° C, initially the mixture is an opaque white solution, which becomes fully transparent once we adjust the pH to 5.3-5.5 with lactic acid (9.3 g). The solution Finish has a soft amber color.
Claims (2)
- \bullet?
- 18-22% en peso de Minoxidil 18-22% by weight from Minoxidil
- \bullet?
- 1-2% de aminoácido Cisteína 1-2% of amino acid cysteine
- \bullet?
- 15.30% en peso de Glicerina 15.30% by weight of Glycerin
- \bullet?
- 8-10% en peso de ácido Láctico 8-10% by weight lactic acid
- \bullet?
- c.s.p. 100% de Etanol c.s.p. 100% Ethanol
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200602140A ES2315115B1 (en) | 2006-07-31 | 2006-07-31 | NEW CAPILLARY SOLUTION CONCENTRATED BASED ON MINOXIDIL. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200602140A ES2315115B1 (en) | 2006-07-31 | 2006-07-31 | NEW CAPILLARY SOLUTION CONCENTRATED BASED ON MINOXIDIL. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2315115A1 true ES2315115A1 (en) | 2009-03-16 |
| ES2315115B1 ES2315115B1 (en) | 2009-12-30 |
Family
ID=40410121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200602140A Expired - Fee Related ES2315115B1 (en) | 2006-07-31 | 2006-07-31 | NEW CAPILLARY SOLUTION CONCENTRATED BASED ON MINOXIDIL. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2315115B1 (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873324A (en) * | 1994-09-06 | 1996-03-19 | Kao Corp | Hair-tonic and hair-growing agent |
| US5801150A (en) * | 1993-06-23 | 1998-09-01 | Caillot; Jean-Luc | Aminopyri(mi)dine derivatives combined with amino acids, and pharmacological activities thereof |
| JPH10279437A (en) * | 1997-03-31 | 1998-10-20 | Shiseido Co Ltd | Hair cosmetic |
| WO2001076540A1 (en) * | 2000-04-07 | 2001-10-18 | Taisho Pharmaceutical Co. Ltd. | Hair growth stimulant compositions |
| EP1269973A1 (en) * | 2000-04-07 | 2003-01-02 | Taisho Pharmaceutical Co., Ltd | Hair growth stimulant compositions |
| US20040191202A1 (en) * | 2003-03-28 | 2004-09-30 | Howard Murad | Methods of promoting hair growth |
-
2006
- 2006-07-31 ES ES200602140A patent/ES2315115B1/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801150A (en) * | 1993-06-23 | 1998-09-01 | Caillot; Jean-Luc | Aminopyri(mi)dine derivatives combined with amino acids, and pharmacological activities thereof |
| JPH0873324A (en) * | 1994-09-06 | 1996-03-19 | Kao Corp | Hair-tonic and hair-growing agent |
| JPH10279437A (en) * | 1997-03-31 | 1998-10-20 | Shiseido Co Ltd | Hair cosmetic |
| WO2001076540A1 (en) * | 2000-04-07 | 2001-10-18 | Taisho Pharmaceutical Co. Ltd. | Hair growth stimulant compositions |
| EP1269973A1 (en) * | 2000-04-07 | 2003-01-02 | Taisho Pharmaceutical Co., Ltd | Hair growth stimulant compositions |
| US20040191202A1 (en) * | 2003-03-28 | 2004-09-30 | Howard Murad | Methods of promoting hair growth |
Non-Patent Citations (3)
| Title |
|---|
| [online] [recuperado el 16.02.2009] Recuperado de WPI Database; DW 200210; nº acceso 2002-075002 & WO 0176540 A1 (TAISHO PHARMA CO LTD) 18.10.2001 (resumen) * |
| [online] [recuperado el 16.02.2009]. Recuperado de: HCaplus en STN, Chemical Abstract Service (Columbus, Ohio, EEUU), nº de acceso 1996:304152 & JP 08073324 A KAO CORP) 19.03.1996 (resumen) * |
| [online][recuperado el 16.02.2009] Recuperado de EPOQUE EPODOC Database & JP 10279437 A (SHISEIDO CO LTD) 20.10.1998 (resumen) * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2315115B1 (en) | 2009-12-30 |
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