KR102006950B1 - Cosmetics compositions for hair growth promoter - Google Patents

Abstract

The present invention relates to a cosmetic composition for promoting wool and hair growth.
The cosmetic composition for promoting wool and hair growth according to the present invention contains a wool and hair growth promoting component having a specific functional group capable of covalently bonding with a protein residue on the skin or hair surface, thus forming a covalent bond without damaging the skin or hair. Provides the desired wool and hair growth promoting effect.

Description

Cosmetic compositions for promoting wool and hair growth {Cosmetics compositions for hair growth promoter}

The present invention relates to a reactive wool, hair growth promoting ingredient, and a cosmetic composition for promoting wool and hair growth, to which a functional group that binds a protein is bound.

Generally, wool and hair-grown products are products used on the scalp to prevent or prevent abnormal hair loss in the human body, or to regrow hair that is missing. It is intended to be applied to the body, spread, or otherwise used in a similar manner to change the appearance or to keep the hair healthy.

Related quasi-drugs are defined as having a milder action and are not used for the treatment or prevention of diseases, but do not have a purpose of use, such as affecting the structure and function of the body, compared to cosmetics.

Generally, hair grows longer and grows longer, but has a lifespan that naturally leaves the hair follicle after three to six years. When the hair goes through the hair cycle in the order of growing, degenerating, and resting phases, the hair stops growing and hair is liable to fall out. Normal people are known to lose 50 to 100 hairs a day. However, due to natural aging, genetic causes, excessive stress, and dietary changes, more hair loss occurs than normal people, and hair thinning hair thinning occurs. The number of men and women who suffer from these symptoms is increasing every year, and the expectation for wool is also increasing.

The causes of hair loss include a decrease in the function of follicles caused by male hormones, a decrease in the metabolic function of the follicles and the hair follicles, a decrease in the physiological function of the scalp, local blood flow disorder due to scalp tension, malnutrition, stress, nutrient side effects, and heredity. Enemy factors are found to be the cause.

Common methods for treating hair loss and hair loss include vasodilation and blood circulation, scalp local irritation, sebum secretion, cell regeneration, nutrition, follicle revival, anti-male hormone, anti-inflammatory (bored), keratin lysis, sterilization, anti-inflammatory, etc. The method of is used.

Generally, the composition for promoting hair and hair growth includes some products for washing, trimming, and protecting the scalp and hair, and for body, such as base, point, bath, restriction, deodorization, and hair removal. Hair-healing hair healing products for hair and scalp include hair products such as washing, treatment, hair, perm, hair dyeing and discoloration, and scalp products such as wool and hair treatment, which have aromatic function And the like.

Common raw materials used to formulate these wool and hair products are oily materials such as fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anionic, cationic, amphoteric and nonionic surfactants. It includes high molecular compounds used as moisturizers, thickeners and film-forming agents, ultraviolet absorbers and blockers, antioxidants, metal ion sequestrants, colorants including dyes and pigments, fragrances, and preservatives.

In addition, the drug extract, capronium chloride, separanthin, which is used for the vasodilation effect and peripheral blood flow promoting effect of peripheral blood vessels to facilitate the nutrient dissemination to the breast papilla and the follicle with the effect of vasodilation and blood flow promoting effect as wool and hair growth promoting ingredients. , 5α-reductase, which acts on the conversion of DHT to pepper tink, canthalistine, l-menthol, and testosterone (Testosterone), which are used to stimulate blood vessels and improve blood circulation by stimulating the scalp To inhibit the physiological activity of male hormones or ingredients that inhibit the activity of female hormones such as estradiol and ethinylestradiol, sebum excess secretion that causes the generation of peroxides and dandruff Pyridoxine hydrochloride, which is used to inhibit and keep clean around the scalp and follicles And blanket release to neglect the development of new and sorbic acid or Les dandruff is used to maintain a clean surrounding worsened and the accompanying inflammation and increased redness or itching, and finally can proceed with hair loss. Therefore, to prevent dandruff, fungicides such as benzalkonium chloride, benzetonium chloride, isopropylmethylphenol, pyroxtonolamine, and klimbazole, and rejuvenate hair cells with reduced function to promote hair growth and hair growth. Pantothenic acid and its derivatives, placenta extract, biotin, mononitroguayacol, photosensitizer 301 and the like are used. In addition, pentadecanoic acid glycerides are used for the purpose of energizing the resting papilla, and various vitamins and amino acids are used as nutrients to hair cells which have degraded due to circulatory disorders of the erased blood vessels. In addition, glycyrrhetinic acid, potassium salt of glycyrrhetinic acid, ammonium salt, allantoin, etc. are used to suppress the inflammation of the scalp caused by the occurrence of dandruff or stimulation of the external world and to maintain a healthy state. It may include vitamins, hormones, amino acids, natural products, and the like.

In addition, to prevent hair loss in the domestic quasi-drugs. Estradiol, ethynylestradiol, benzoate estradiol, estrone, hydrocortisone, prednisolone (acetic acid) diphenhydramine, dipotassium hydrosulfite, pyridoxin hydrochloride, dipyrilate pyridoxine, tricosaccharide, tocopherol / Tocopherol Acetate, Glucose Extract, Separantin, Hinokithiol, Dexpanthenol, Pantothenyl Ether, Sodium Pantothenate / Calcium, Photosensitive, Biotin, Resorcin, Salicylic Acid, Isopropylethylphenol, Mononitroguayacol, Glue Pharmaceutical agents such as chlorohexidine solution, ethyl nicotinate, nicotinic acid benzyl, nicotinic acid amide, capsicum tink, menthol, lacsogen, cholesterol, swolchol, soluble cystine, high ginseng tink, secintink and the like can also be used.

In addition, the hair growth agents include the leek extract, purple bitter extract, separanthin, vitamin E and derivatives of the functional group, gamma-orizarol and other ingredients that promote blood circulation, pepper tink, cantharis tink ( cantharis tinc), health tincture, vasodilators including topical irritants such as nicotinic acid benzyl ester. In addition, vitamins A, B1, B2, B6, E and derivatives in combination with functional groups, pantothenic acid and derivatives in combination with functional groups, vitamins such as biotin and cystine, cysteine, methionine, leucine, tryptophan, amino acid extracts Female hormones such as wool, estradiol, ethynyl estradiol, pantothenic acid, and functional groups to resolve hair cell nutritional disorders caused by capillary circulatory disorders around the nipple and hair cells using amino acids, etc. Derivatives, placenta extract, allantoin, hair root activator such as photosensitizer 301, moisturizing agents such as glycerin and pyrrolidone carboxylic acid, which are formulated to prevent drying of the scalp, dandruff itching agent, menthol, camphor, etc. Freshener ingredients.

However, when used for scalp and hair as such a hair and hair growth promoting ingredient, it provides only a temporary effect until the next cleaning after treatment, and there is always the hassle of reprocessing after cleaning.

Patent document 1 relates to a non-aqueous personal care product for skin or hair, wherein a functional group capable of covalently bonding to protein residues on the hair or skin surface in a non-aqueous part is carbonate, aldehyde, propionaldehyde, Butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide ), Hydroxysuccinimidyl ester, imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, Ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic ester, Group consisting of disulfide, ketone and functional group represented by RX (R is any one selected from the group consisting of alkyl, aryl, aralkyl, ring and unsaturated ring, X is I, Br or Cl) Although it comprises a conditioning component having any one or more selected from the non-aqueous part and the water-based part, and discloses a personal care product for hair or skin, characterized in that the mixture is used immediately before use, but the various functional groups In the case of the target, lysine, which is harmful to the human body or contains a small amount of amino acids in the protein constituting the hair or skin, such as hair (1.9-3.1%) and skin keratin (3.1-6.9%), or hair (16.6) ~ 18%) and the skin keratin (2.3 ~ 3.8%) of the target cysteine to react because the reaction efficiency is reduced and each material There is a problem that must be synthesized.

Korean Unexamined Patent No. 2008-0064467

It is an object of the present invention to provide a cosmetic composition for promoting wool and hair growth that can continuously give a semi-permanent wool, hair growth promoting effect without damaging the hair or skin.

As a means for solving the above problems, the present invention provides a cosmetic composition for promoting wool and hair growth comprising a carbodiimide compound and wool and hair growth promoting components.

As another means for solving the above problems, the present invention provides a carbodiimide, imido ester, aryl azide, diazirine, hydroxymethyl phosphine, pentafluorophenyl ester, pyridyl disulfide, Provides a reactive wool / hair growth promoting component having a functional group covalently bonded to one or more hairs or proteins on the skin surface selected from the group consisting of sulfo-hydroxysuccinimide esters, alkoxy amines, hydrazides, haloacetyls, and azides. .

As another means for solving the above problems, the present invention provides a cosmetic composition for promoting wool and hair growth comprising the reactive wool, hair growth promoting ingredients.

The cosmetic composition for promoting hair and hair growth according to the present invention contains a reactive wool / hair growth promoting component and / or a carbodiimide-based compound incorporating a specific functional group capable of covalently bonding with protein residues of the hair or skin, and thus to the hair or skin. It forms covalent bonds without damage and provides the effect of promoting wool and hair growth permanently.

The present invention relates to a cosmetic composition for promoting hair growth and hair growth comprising a carbodiimide compound and a sheep growth control component.

The cosmetic composition for promoting wool and hair growth according to the present invention may react with a carbodiimide-based compound to a known wool and hair growth promoting component, for example, to react hair or skin through a reactive wool and hair growth promoting component to which a carbodiimide group is bound. It is possible to maximize the effect of promoting wool and hair growth by forming covalent bonds with proteins.

The carbodiimide-based compound may be included in an amount of 0.001 to 10% by weight, 0.01 to 7% by weight, or 0.1 to 5% by weight based on 100% by weight of the total composition. If the content is less than 0.001% by weight, there is a problem that it is difficult to exhibit continuous wool and hair growth promoting effect. If the content exceeds 10% by weight, the carbodiimide-based compound that is excessively present beyond the reaction site present in the skin or hair may be skin or hair. There is a problem that can act as a component that does not help to improve the sustainability by reacting with the efficacious substances in the state that does not react with.

In the present invention, the term "hair and hair growth promoting effect" refers to a hair growth function for preventing abnormal hair loss or progression of hair, regrowing missing hair, or a hair growth function.

The wool / hair growth promoting component used in the present invention may be selected from the natural extracts such as copper, plants, minerals, amino acids, peptides, proteins, sugars, vitamins, and the like. It may include, but is not limited thereto. For example, medicinal extracts, capronium chloride, separanthin, benzyl nicotinate, l-menthol, estradiol, ethynylestradiol, pyridoxine hydrochloride, salicylic acid, resorcin, benzalkonium chloride, benzetonium chloride, iso Propylmethylphenol, pyrotonolamine, klimbazole, pantothenic acid, placenta extract, biotin, mononitroguayacol, photosensitizer, pentadecanoic acid glyceride, glycyrrhetinic acid, potassium or ammonium salt of glycyrrhetinic acid, allantoin, Minoxidil, steroid, estradiol, estrone, hydrocortisone, prednisolone (acetic acid) hydrocortisone, prednisolone, diphenhydramine, diglycisine dipotassium, dicaprylic acid pyridoxine, tricosaccharide, tocopherol / tocopherol, hinokthiol, dexantenyl, pantothenyl Ether, sodium pantothenate / calcium, isopropylethylphenol, mononitroguayacol, chlorohexyl gluconate solution, ethyl nicotinate, nico Acidamide, Capsicum Tin, Resogen, Cholesterol, Swimmers, Soluble Cystine, Red Ginseng Tin, Sessin Tin, Bupyeongcho Extract, Bitter Extract, Separantin, Gamma-Orizalol, Cantharis Tinc, Health Tin, nicotinic acid benzyl ester, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin E, cystine, cysteine, methionine, leucine, tryptophan, glycerin, pyrrolidone carboxylic acid, and camphor.

It is preferable to use 0.001-50 weight part, 0.001-30 weight part, 0.01-10 weight part, or 0.1-5 weight part with respect to 100 weight part of whole compositions for the said wool, hair growth promoting component. If the content thereof is less than 0.001 part by weight, there is a problem of effective performance limitation, and if it exceeds 50 parts by weight, there is a problem in formulation and formulation stabilization.

In particular, the wool / hair growth promoting component in the present invention can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.

In addition, in the present invention, the wool / hair growth promoting component may have a functional group capable of covalent bonding with protein residues on the hair or skin surface.

The functional group covalently bonded with the protein is carbodiimide, imido ester, aryl azide, diazirine, hydroxymethyl phosphine, pentafluorophenylester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy amine, Hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester , Imidazole, oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone This is not restrictive.

In addition, the protein may include a reactive moiety of thiol, hydroxyl, carboxyl or amine.

The carbodiimide-based compound is a generic term for a compound containing a structure represented by the following formula (1) in a molecule.

[Formula 1]

-N = C = N-

The carbodiimide-based compound preferably includes at least 1 to 1000 structures of Formula 1, more preferably 1 to 100 structures represented by Formula 1 in a molecule, It is more preferable to include 1 to 10 structures represented in the molecule.

In this case, when the number of carbodiimide groups represented by the formula (1) in one molecule exceeds 1000, the viscosity of the raw material is too large, the molecular weight is too large, and the reaction sites that can react too much are excessively large, and The molecule | numerator which has a bodyimide group becomes so large that the problem which efficiency falls by covering the part which shows the functional effect of the molecule which has a substantial function arises.

Specific examples of the carbodiimide-based compound in the present invention may be a compound represented by the following formula (2), n is 4 and m is 11 in the formula (2) is benzene, 1,3, -bis (1- Isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-meth-ether-block (Benzene, 1,3-bis (1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono- Me-ether-blocked) (hereinafter referred to as polymer type carbodiimide compound of Formula 2).

(2)

In Formula 2, n is 1 to 100, m is 1 to 100.

In another embodiment of the carbodiimide-based compound in the present invention, as a compound represented by the following formula (3), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimideHCl) can be used.

(3)

In a preferred embodiment of the cosmetic composition for promoting wool and hair growth according to the present invention, the carboxyl wool and hair growth promoting component is made into a reactive ester wool and hair growth promoting component having direct bioreactivity, or hair (17.5 to 21.9% Reactivity using carbodiimide-based compounds that can be targeted by wool and hair growth promoting components containing amine groups by reactive esterification of amino acids (ex, aspartic acid, glutamic acid) present in excess of keratin (15.5-23.5%) The effect can be remarkably increased by making an ester form (reactive wool, hair growth promoting component) having an increase in reaction efficiency. In addition, carbodiimides, imidoesters, arylazides, diazirines, hydroxymethyl phosphines, pentafluorophenylesters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy, which may target other amino acids The effect can be further enhanced by using a wool / hair growth promoting component containing a functional group such as amine, hydrazide, haloacetyl, and azide in the molecule.

In a more preferred embodiment, the polymer or carbodiimide compound of formula (2) or 1-ethyl-3- (3-dimethylaminopropyl) Carbodiimide-based compounds such as hydrochloric acid (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl) are first reacted to form reactive esters, and wool having amines in the molecule again with the reactive ester functional groups formed Excellent hair and hair growth promoting effect can be obtained by reacting a hair growth promoting component or by reacting with an amine on the surface of hair or skin. In the reaction, the reaction may be preferably performed at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at a pH of 4 to 5 in an acidic to weakly acidic aqueous solution. The most reaction efficiency can be increased. The reaction is completed within 1 to 30 minutes.

In Reaction Scheme 1, a carboxyl-containing wool / hair growth promoting component molecule was first reacted with a carbodiimide-based compound to form a reactive ester, followed by reaction with an amino acid of a living body having an amine residue to form a covalent bond. .

[Reaction Scheme 1]

In the following scheme 2, aspartic acid and glutamic acid, which are biological amino acids having a carboxyl group on the surface of the protein of the hair or skin, are first reacted with a carbodiimide compound to form a reactive ester, followed by reaction with a wool / hair growth promoting component having an amine residue. A schematic of the reaction for forming a bond is shown.

[Reaction Scheme 2]

Carbodiimide-based compounds increase the reaction efficiency of hair or skin proteins with wool and hair growth promoting components. Reactive wool and hair growth promoting components bound to hair or skin do not come off during normal cleaning due to shampoo or soap. It can remain attached to hair or skin almost permanently.

The present invention also provides carbodiimide groups, imido esters, aryl azides, diazirines, hydroxymethyl phosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters in wool and hair growth promoting components. , Alkoxy amine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxy Selected from the group consisting of succinimidyl ester, imidazole, oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone Reactive wool and hair growth promoting components with functional groups covalently bound to one or more proteins . ≪ / RTI >

For example, as shown in Scheme 1, the carbodiimide-based compound may include wool and hair growth promoting components to which the carbodiimide group formed by primary reaction. The present invention may also include a cosmetic composition for promoting hair growth and hair growth comprising the reactive wool and hair growth promoting component.

In the cosmetic composition for promoting wool and hair growth according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, long-chain alkyl quaternary ammonium salts such as straight and branched chains, etc. Formulation may be facilitated when used in combination with a cationic polymer such as cationic surfactant, cationic cellulose, cationic guar, and cationic polyvinylpyrrolidone, and silicone. In addition, to formulate into cosmetic formulations for the formulation of cosmetics such as solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusters, metal ion sequestrants, colorants, pearlescent agents, cosmetics, pigments, powder particles, etc. Components may be incidentally included. The component for the formulation may be used 40 to 99 parts by weight based on 100 parts by weight of the total composition.

The cosmetic composition for promoting wool and hair growth according to the present invention can be used for the formulation of a cosmetic composition for promoting hair and hair growth, including a component of wool and hair growth promoting function having a functional group. Hair application products may include all formulations such as shampoos, rinses, treatments, hair packs, hair essences, waxes, gels, sprays and the like.

More preferably, the cosmetic composition for promoting wool and hair growth according to the present invention includes a carbodiimide-based compound and a wool and hair growth promoting component having a reactive functional group, and when the above agent is deteriorated in water, It is easier to maintain its activity in non-aqueous formulations, and the reaction may occur by mixing with a buffer for pH control immediately prior to use, or by contacting with water during the cleaning process. Examples of non-aqueous formulations include liquid form, sheet form, powder powder form, tablet form, oil, wax, ampoule, gel and the like used as conventional non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the wool / hair growth promoting component can be formulated as a single agent in encapsulated form or as two agents in separate forms, respectively. In addition, a method of blocking a derivative of a form in which a reactive functional group and a component having a hair and hair growth promoting function are combined through encapsulation from water can also be used.

2-basic acid ester oils and polyols, such as dioctyl succinate, dioctyl adipate, diethyl sebacate, and the like, in order to enhance the wool and hair growth promoting effect having functional groups in the cosmetic composition for promoting wool and hair growth according to the present invention; Polyethylene glycol, propylene glycol, hexylene glycol, butanediol and their isomers, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The above-mentioned solvents increase the permeability of hair or skin and are used as solvents of poorly soluble substances. More preferably, solvents used to increase the activity retention effect of the wool / hair growth promoting component having a functional group include diethyl sebacate, ethoxyglycol, bis-ethoxyglycol cyclohexane 1,4-dicarboxylate, and the like. .

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example  1 to 6 and Comparative Example  1-3

The hair growth compositions of Examples 1 to 6 and Comparative Examples 1 to 3 were prepared using the compositions and contents shown in Table 1 below, and the prepared compositions were evaluated by 15 subjects who felt hair loss for each composition. Evenly, incubate at room temperature for 30 minutes, induce reaction and rinse with primary running water and shampoo once daily for 5 days, then after 10 days, 5 points scale (5 very good, 4 slightly Wool, hair growth effects were compared with the sensory performance of excellent, no 3 difference, no 2 effect, and 1 no effect.

division
(weight%) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Distilled water 49.0 49.0 49.0 48.0 48.0 48.0 48.0 48.0 48.0 Pantothenic acid 1.0 - - 1.0 - - 1.0 - - Nicotinic acid amide - 1.0 - - 1.0 - - 1.0 - Biotin - - 1.0 - - 1.0 - - 1.0 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide. Hydrochloric acid - - - 1.0 1.0 1.0 - - - Benzene, 1,3, -bis (1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-meth-ether-block - - - - - - 1.0 1.0 1.0 Buffer
(pH 4.5) 50.0 50.0 50.0 50.0 50.0 50.0 50.0 50.0 50.0 Sum 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0

As a result of the experiments of Examples 1 to 6 and Comparative Examples 1 to 3 (Table 2), carbodiimide was compared to Comparative Examples 1 to 3 in which the bioreactive group was not substituted with carbodiimide as a wool / hair growth promoting component. Examples 1 to 6, including the carbodiimide covalent bond formation effect, showed a better hair and hair growth improvement effect, especially Examples 4 to 6 using a polymer carbodiimide showed a better hair and hair growth improvement effect .

Sensory evaluation
(N = 5 each) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Improvement effect
(5-point scale) 1.7 2.0 1.8 3.2 3.3 3.4 3.8 3.7 3.7

Formulation example  One: Hair restorer  Produce

According to the conventional hair growth preparation method, the hair growth preparation was prepared using the ingredients and contents shown in Table 3 below.

Component (% by weight) Hair restorer Pantothenic acid 0.5 Nicotinic acid amide 0.5 Biotin 0.5 Niacinamide 1.0 Benzene, 1,3, -bis (1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-meth-ether-block 1.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Phage-12 nonylphenyl ether 0.3 Polysorbate 80 0.5 ethanol 10.0 Triethanolamine 0.1 antiseptic Suitable amount Spices Suitable amount Buffer (pH 4.5) Balance Sum 100.0

Claims (9)

A carbodiimide compound represented by the following formula (2); And a wool / hair growth promoting component having a functional group capable of covalently bonding with a protein residue on the hair or skin surface.
(2)

In the above formula (2), n is 1 to 100 and m is 1 to 100.
The method of claim 1,
The said wool and hair growth promoting component is a cosmetic composition for promoting hair and hair growth which contains a carboxyl group or an amine group in a molecule | numerator.
The method of claim 1,
The hair and hair growth promoting ingredients include medicinal extracts, capronium chloride, separanthin, benzyl nicotinate, l-menthol, estradiol, ethynylestradiol, pyridoxine, salicylic acid, resorcin, benzalkonium chloride, and benzetonitrile chloride. Potassium or ammonium salts of um, isopropylmethylphenol, pyroxtonolamine, klimbazole, pantothenic acid, placenta extract, biotin, mononitroguayacol, photosensitizer, pentadecanoic acid glyceride, glycyrrhetinic acid, glycyrrhetinic acid , Allantoin, minoxidil, steroid, benzoic acid estradiol, estrone, (acetic acid) hydrocortisone, prednisolone, diphenhydramine, glycyrizine dipotassium, dicaprylic acid pyridoxine, tricosaccharide, tocopherol / tocopherol, hinokthiol, dexpanthenol Pantothenylethyl ether, sodium pantothenate / calcium, isopropylethylphenol, mononitroguayacol, chlorohexyl gluconate solution, Ethyl cortinate, nicotinic acid amide, red pepper tin, lysogen, cholesterol, swollenol, soluble cystine, red ginseng tink, sessin tink, Bupyeongcho extract, bitter orange extract, separanthin, gamma-orizarol, cantharistine tinc), health tincture, nicotinic acid benzyl ester, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin E, cystine, cysteine, methionine, leucine, tryptophan, glycerin, pyrrolidone carboxylic acid and camphor Cosmetic composition for promoting wool and hair growth as described above.
delete The method of claim 1,
The functional group covalently bonded with the protein is imidoester, arylazide, diazirine, hydroxymethyl phosphine, pentafluorophenylester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy amine, hydrazide, Haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester, imidazole, Cosmetics for promoting wool and hair growth, which are at least one selected from the group consisting of oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone Composition.
The method of claim 1,
A cosmetic composition for promoting wool and hair growth, wherein the carbodiimide compound is contained in an amount of 0.001 to 10% by weight in 100% by weight of the total composition.
The method of claim 1,
The carbodiimide-based compound and the wool / hair growth promoting component are formulated in a single agent in encapsulated form; A cosmetic composition for promoting hair and hair growth, wherein the carbodiimide compound and the hair and hair growth promoting ingredient are each formulated in two separate forms.
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