KR20150066811A - Cosmetics compositions for hair growth promoter - Google Patents
Cosmetics compositions for hair growth promoter Download PDFInfo
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- KR20150066811A KR20150066811A KR1020130152321A KR20130152321A KR20150066811A KR 20150066811 A KR20150066811 A KR 20150066811A KR 1020130152321 A KR1020130152321 A KR 1020130152321A KR 20130152321 A KR20130152321 A KR 20130152321A KR 20150066811 A KR20150066811 A KR 20150066811A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
Description
The present invention relates to a reactive wool / hair growth promoting component to which a functional group binding to a protein is bonded, and a cosmetic composition for promoting hair and hair growth.
In general, wool and hair care products are products used in scalp to prevent or prevent the abnormal hair loss of human body, especially hair, or to restore hair that is missing, It is intended to change the appearance, or to apply it to the body in order to keep the hair healthy, to spread, to use in a similar way to these.
Related quasi-drugs are defined as not having the purpose of use such as affecting the structure and function of the body, rather than being used for the treatment or prevention of diseases, even though the action on the human body is smaller than that of the cosmetics.
In general, the hair grows to a longer length, but after a lifetime of 3 to 6 years it naturally falls off the hair follicle. When the hair passes through the hair cycle in the order of growing, regenerating, and resting, the hair stops growing and the hair becomes easy to fall off when it becomes a retrogressive or resting period. Normal people are known to have 50 to 100 hairs per day. However, due to natural aging, genetic causes, excessive stress, dietary changes, etc., hair loss and hair thinning tend to occur. The number of men and women who are troubled by these symptoms is increasing every year, so expectation for the hair dye is also increasing.
Such hair loss may be caused by a decrease in blanch function caused by male hormone, a decrease in the metabolism function of blanket and parental parts, a decrease in scalp physiological function, a local blood flow disorder caused by scalp tension, malnutrition, stress, The causes are identified as the cause.
Common methods for treating hair loss and thinning include vasodilatation and blood circulation promotion, scalp local stimulation, suppression of sebum secretion, cell renewal, nutritional supplementation, resurfacing of blanks, anti-male hormone, anti-inflammatory (boring), keratolysis, sterilization, Is used.
In general, the composition for promoting wool and hair growth includes parts for cleansing, tidying up, and protecting the scalp and hair, and body products such as base, point, bath, restriction, deodorant and hair removal. Hair wool healing products for hair and scalp include products for the hair such as cleaning, treatment, regular hair, fur, hair, decolorization and scalp products such as wool and hair tonic treatments, And the like.
Typical raw materials used to formulate these wool and hair products include oily materials such as oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anionic, cationic, amphoteric and nonionic surfactants , A polymer compound used as a moisturizing agent, a thickening agent and a film former, an ultraviolet absorbing and blocking agent, an antioxidant, a sequestering agent, a coloring material including a dye and a pigment, a fragrance, a preservative and the like.
In addition, as a component promoting wool and hair growth, it is possible to use an extract of Angelica gigas Nakai, which is used for vasodilating effect and blood flow promoting effect of peripheral blood vessels in order to smoothly supply nutrition to the papilla and blanket with vasodilation and blood flow promoting effect, , Benzyl nicotinate, 5α-reductase, which acts on cholinesterase, kantalystin, l-menthol, testosterone and DHT to convert blood vessels and blood circulation by stimulating scalp, For the purpose of alleviating the physiological action of a component or male hormone that inhibits the activity of estradiol or ethinylestradiol, an excessive secretion of sebum which causes the generation of female hormones, peroxidative substances or dandruff, such as estradiol, ethinylestradiol Which is used to keep the scalp and blanket clean around, And blanket release to neglect the development of new and sorbic acid or Les dandruff is used to maintain a clean surrounding worsened and the accompanying inflammation and increased redness or itching, and finally can proceed with hair loss. Therefore, for the purpose of promoting the growth of hair and hair by reviving bacteriocidal agents such as benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, pylontonolamine, climbazole and the like and dysfunctional hair cells to prevent dandruff Pantothenic acid and derivatives thereof, placenta extract, biotin, mononitroguyaqual, photosensitizer 301, and the like. In addition, pentadecanoic acid glyceride is used for the purpose of energizing the dermal papilla of the dormant period, and various vitamins and various amino acids are used as nutrients to the dermal cells whose functions are deteriorated by the circulatory disturbance of the erythrocyte. In addition, glycyrrhetinic acid, potassium salt or ammonium salt of glycyrrhetinic acid, allantoin and the like are used to suppress the inflammation of the scalp caused by the occurrence of dandruff and external stimuli and to maintain a healthy state, and other minoxidil, steroid , Vitamins, hormones, amino acids, and natural-derived medicines.
Also, to prevent hair loss in domestic quasi-drugs. It has been found that the use of hairdressing products such as estradiol, ethinyl estradiol, benzoic acid estradiol, estrone, hydrocortisone (acetic acid) hydrocortisone, prednisolone, diphenhydramine hydrochloride, dipotassium glycyrrhizinate, pyridoxine hydrochloride, pyridoxine dicaprylate, tricosaccharide, The present invention relates to the use of a compound of formula I in the preparation of a medicament for the treatment and / or prophylaxis of tocopherol, acaricidal xanthate, cephalanin, hinokitiol, dexpanthenol, pantothenic acid ethyl ether, sodium pantothenate / calcium, Medicines such as benzoyl nicotinate, benzoic nicotinate, nicotinamide, cholestin, menthol, razogen, cholesterol, sulchiol, soluble cystine, gossam tincture, and sezginin can also be used.
Examples of hair regrowth agents include blood purifying extracts such as bupyeongchu extract, frequently used puff extract, sepharanthin, vitamin E and its functional group-binding derivatives, gamma-oryzaeol, cantharis tinc, healthy tinctures, and nicotinic acid benzyl esters. In addition, it is also possible to use vitamin A, B1, B2, B6, E and derivatives thereof in which the functional groups are bonded, derivatives of pantothenic acid and its functional groups, vitamins such as biotin and cystine, cysteine, methionine, leucine, tryptophan, And the like, a hair follicle for solving a hairy cell nourishment disorder caused by a capillary circulation disorder around a papilla and a hairy cell, a female hormone agent such as estradiol and ethinyl estradiol, a pantothenic acid, Herbal remedies such as herbal remedies, derivatives, placenta extract, allantoin, and photoreactor 301, moisturizing agents such as glycerin and pyrrolidonecarboxylic acid to prevent drying of the scalp, and dandruff itching agents, ≪ / RTI >
However, when used for scalp and hair, these wool and hair promoting ingredients provide only a temporary effect until the next cleansing after the treatment, but there is always the hassle of reprocessing after cleansing.
Patent Document 1 discloses a non-aqueous personal care product for skin or hair, which comprises a non-water-based functional group capable of forming a covalent bond with a hair or a protein residue on the surface of a skin, such as carbonate, aldehyde, propionaldehyde, But are not limited to, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, A hydroxysuccinimidyl ester, an imidazole, an oxycarbonylamidazole, an imine, a thiol, a maleimide, a vinylsulfone, For example, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic ester, (Wherein R is any one selected from the group consisting of alkyl, aryl, aralkyl, cyclic and unsaturated rings, and X is I, Br or Cl) represented by the following formula And a water-based part containing a conditioning component having at least one selected from the group consisting of the above-mentioned various kinds of functional groups, (1.9 to 3.1%) and skin keratin (3.1 to 6.9%) in the amino acids of the proteins constituting the hair or the skin, ~ 18%) and skin keratin (2.3 ~ 3.8%) are targeted and reacted, so that the reaction efficiency is lowered. There is a problem in that it must be synthesized.
It is an object of the present invention to provide a cosmetic composition for promoting wool and hair growth which is capable of continuously imparting the effect of promoting a permanent wool and hair growth without damaging the hair or skin.
As a means for solving the above problems, the present invention provides a cosmetic composition for promoting wool and hair growth comprising a carbodiimide compound and a wool / hair growth promoting component.
As another means for solving the above-mentioned problems, the present invention provides a wool / hair growth promoting component which comprises at least one member selected from the group consisting of carbodiimide, imidoesters, aryl azides, diazirines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, A reactive wool and hair growth promoting component to which at least one hair selected from the group consisting of sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, and azide, or a functional group covalently bonding with a protein on the skin surface is bonded .
As another means for solving the above problems, the present invention provides a cosmetic composition for promoting wool and hair growth, comprising the reactive wool / hair growth promoting component.
The cosmetic composition for promoting hair and hair growth according to the present invention contains a reactive wool / hair growth promoting component and / or a carbodiimide-based compound into which specific functional groups capable of covalently bonding with hair or skin protein residues are introduced, It forms a covalent bond without damage and provides semi-permanent promoting effects of wool and hair growth.
The present invention relates to a cosmetic composition for promoting wool and hair growth comprising a carbodiimide compound and a positive /
The cosmetic composition for promoting wool and hair growth according to the present invention can be produced by, for example, reacting a known wool / hair growth promoting component with a carbodiimide compound to form a reactive wool / hair growth promoting component to which a carbodiimide group is bonded, By forming a covalent bond with the protein of the present invention, it is possible to maximize the effect of promoting wool and hair growth.
The carbodiimide compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the total composition. When the content of the carbodiimide compound is less than 0.001 part by weight, there is a problem that the effect of promoting continuous wool and hair growth is difficult to be exhibited. When the content exceeds 10 parts by weight, , There is a problem that it can act as a component to be lost, which does not help to improve persistence.
In the present invention, the term " wool and hair growth promoting effect " refers to a function of preventing abnormal hair loss or hair growth of hair, a hair growth function to restore missing hair, or a function of rapidly growing hair.
The wool and hair growth promoting component used in the present invention is a wool and hair growth promoting component that can fill skin or hair damaged areas such as extracts derived from natural materials such as copper, plants and minerals, amino acids, peptides, proteins, sugars and vitamins But are not limited thereto. For example, it is possible to use the extract of the present invention, the extract of Pseudomonas exotoxin, chlorpromium chloride, sepharanthin, benzyl nicotinate, l-menthol, estradiol, ethinyl estradiol, pyridoxine hydrochloride, salicylic acid, resorcinol, benzalkonium chloride, benzethonium chloride, Potassium salt or ammonium salt of glycyrrhetinic acid, ammonium salt of allantoin, glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhetinic acid, propylmethylphenol, pylontonolamine, climbazole, pantothenic acid, placenta extract, biotin, mononitroguacol, (Hydroxycarboxylic acid), tocopherol / tocopherol acetate, hinokitiol, dexpanthenol, pantothenylyl ethyl, dicyclohexylcarbodiimide, dicarboxylic acid dicarboxylic acid, Ether, sodium pantothenate / calcium, isopropyl ethyl phenol, mononitro guaiacol, chlorohexadecyl gluconate, ethyl nicotinate, Nico Cantharis tinc, cantharis tinc, cholesterol, cholesterol, sulchiol, licorice cystine, gossam tincture, sezin tincture, bupyeongchu extract, Tincture, benzyl ester of nicotinic acid, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin E, cystine, cysteine, methionine, leucine, tryptophan, glycerin, pyrrolidone carboxylic acid and camphor.
The wool / hair growth promoting component is preferably used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the total composition. If the content is less than 0.001 part by weight, there is a problem of effective performance limit. If the content is more than 50 parts by weight, there is a problem in formulation and formulation stabilization.
In particular, in the present invention, the wool / hair growth promoting component can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.
In the present invention, the wool / hair growth promoting component may be one having a functional group capable of covalently bonding to the hair or the protein residues on the skin surface.
The functional groups covalently bonded to the protein include carbodiimide, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy amines, The present invention also relates to a process for the preparation of a medicament for the treatment and / or prophylaxis of a disease or condition selected from the group consisting of hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenylcarbonate, aziridine, isocyanate, thiocyanate, epoxide, May be at least one selected from the group consisting of imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone , But is not limited thereto.
In addition, the protein may comprise reactive residues of thiol, hydroxyl, carboxyl or amine.
The carbodiimide compound is generally referred to as a compound containing a structure represented by the following formula (1) in the molecule.
[Chemical Formula 1]
-N = C = N-
The carbodiimide compound preferably has at least 1 to 1000 structures represented by the formula (1), more preferably 1 to 100 structures represented by the formula (1) It is more preferable that the structure includes 1 to 10 structures in the molecule.
In this case, if the number of the carbodiimide groups represented by the formula (1) exceeds 1,000 in one molecule, the viscosity of the starting material is too large, the molecular weight is excessively large, the reaction position where the reaction can be performed becomes excessively large, The molecule having the bodymide group becomes too large, and the efficiency is lowered by blocking the portion showing the functional effect of the molecule having the substantial function.
In the present invention, a specific example of the carbodiimide compound may be a compound represented by the following formula (2), wherein n is 4 and m is 11 in the following formula (2): benzene, 1,3, Isocyanato-1-methylethyl) -, homopolymer, polyethylene glycol mono-ether-block (benzene, 1-isocyanato- Me-ether-blocked (hereinafter referred to as polymeric carbodiimide compound of formula (2)).
(2)
In the above formula (2), n is 1 to 100 and m is 1 to 100.
Another example of the carbodiimide compound in the present invention is 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide, which is a compound represented by the following formula (3) carbodiimide or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl may be used.
(3)
In one preferred embodiment of the cosmetic composition for promoting wool and hair growth according to the present invention, a wool / hair growth promoting component having a carboxyl group is directly made into a reactive ester wool / hair growth promoting component having a bioreactivity, or hair (17.5 to 21.9% ) And an excess amount of amino acid (ex, aspartic acid, glutamic acid) present in the skin keratin (15.5 to 23.5%) is reactively esterified using a carbodiimide compound capable of targeting a wool / hair growth promoting component containing an amine group (Reactive wool / hair growth promoting component) to increase the reaction efficiency, the effect can be significantly increased. In addition, it is also possible to use carbodiimides, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy The effect can be further enhanced by using a wool / hair growth accelerating component containing a functional group such as amine, hydrazide, haloacetyl, or azide in the molecule.
In a more preferred embodiment, the polymeric carbodiimide compound of Formula 2 or 1-ethyl-3- (3-dimethylaminopropyl) carbamate is first added to the protein surface of the skin or hair of the wool / hair growth promoting component molecule having a carboxyl group, A carbodiimide compound such as 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl is firstly reacted to form a reactive ester, and the resulting reactive ester functional group is reacted with a wool ㆍ Excellent hair and hair growth promoting effect can be obtained by reacting hair growth promoting component or by reacting with hair or skin amine surface. The reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, most preferably at an acidic to slightly acidic pH of about 4 to 5 The reaction efficiency can be increased most. The reaction is completed within 1 minute to 30 minutes.
In the following Reaction Scheme 1, a wool / hair growth promoting component molecule having a carboxyl group reacts with a carbodiimide compound first to form a reactive ester, followed by reaction with an amino acid having an amine residue to form a covalent bond .
[Reaction Scheme 1]
In the following Reaction Scheme 2, asparaginic acid and glutamic acid, which are carboxylamino group-bearing biological amino acids of the surface of hair or skin proteins, first react with a carbodiimide compound to form a reactive ester and then react with a wool / hair growth promoting component having an amine residue to share Bond is formed.
[Reaction Scheme 2]
The carbodiimide compound increases the reaction efficiency of the hair or skin protein and the wool / hair growth promoting component, so that the reactive wool / hair growth promoting component bound to the hair or the skin comes off well during general cleaning due to shampoo or soap And can remain almost permanently attached to the hair or skin.
The present invention also provides a method for producing a wool / hair growth promoting composition comprising adding to a wool / hair growth promoting component a carbodiimide group, an imidoester, an aryl azide, a diazirine, a hydroxymethylphosphine, a pentafluorophenyl ester, a pyridyl disulfide, a sulfo-hydroxysuccinimide ester , Alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxy Selected from the group consisting of succinimidyl esters, imidazoles, oxycarbonylamidazoles, imines, thiols, maleimides, vinyl sulfones, ethyleneimines, thioethers, acrylonitriles, acrylic acid or methacrylic esters, disulfides and ketones A reactive wool / hair growth accelerating component having a functional group covalently bonded to at least one protein . ≪ / RTI >
For example, as shown in Reaction Scheme 1, the carbodiimide compound may be combined with a carbodiimide group to generate a wool / hair growth promoting component. In addition, the present invention may include a cosmetic composition for promoting wool and hair growth comprising the reactive wool / hair growth promoting component.
In order to increase the secondary effects of the cosmetic composition for promoting wool and hair growth according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, long chain alkyl quaternary ammonium salts of straight chain and branched chain, etc. The cationic surfactant, the cationic cellulose, the cationic guar, the cationic polymer such as cationized polyvinylpyrrolidone, silicone, etc., can be easily formulated. In order to formulate cosmetics such as solvents, surfactants, thickeners, stabilizers, preservatives, coloring agents, pH adjusters, metal ion sequestering agents, coloring agents, pearlizing agents, external appearance improvers, pigments and powder particles, Components may be incidentally included. The ingredients for the formulation may be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the total composition.
The cosmetic composition for promoting wool and hair growth according to the present invention can be used for the formulation of a cosmetic composition for promoting wool and hair growth, including components having a wool and hair growth promoting function having a functional group. Hair application products may include all formulations such as shampoo, rinse, trimming, hair pack, hair essence, wax, gel, spray and the like.
More preferably, the cosmetic composition for promoting wool and hair growth according to the present invention contains a carbodiimide compound and at the same time a wool / hair growth promoting component having a reactive functional group. When the activity of the above preparation is lowered in the aqueous system, It may be easier to maintain its activity in non-aqueous formulations and may be mixed with a buffer for pH control just prior to use, or may be brought into contact with water during the washing process. Examples of non-aqueous formulations include liquid, sheet, powder, tablet, oil, wax, ampoule, gel and the like which are used as ordinary non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the wool / hair growth promoting component can be formulated in a single form in an encapsulated form or in two separate forms. In addition, a method of blocking a derivative having a reactive functional group and a component having a wool / hair growth promoting function from binding through moisture through encapsulation can also be used.
In the cosmetic composition for promoting hair and hair growth according to the present invention, in order to enhance the effect of promoting wool and hair growth having functional groups, 2-basic acid esters such as dioctyl succinate, dioctyl adipate, diethyl sebacate, Polyethylene glycol, propylene glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof. The above-mentioned solvents increase the permeability of hair or skin and are used as a solvent of a poorly soluble substance. More preferably, the solvent used for enhancing the activity maintaining effect of the wool / hair growth promoting component having a functional group is diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate and the like .
Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.
Example 1 to 6 and Comparative Example 1-3
The compositions for wool hair growth of Examples 1 to 6 and Comparative Examples 1 to 3 were prepared by the compositions and contents shown in the following Table 1, and the resulting composition was applied to 15 persons, (5 excellent, 4 slightly) after 10 days after 5 days. After 5 days, the reaction was induced by standing for 30 minutes at room temperature and then washed with running water and shampoo. (No effect, no effect, no effect, no effect).
(weight%)
(pH 4.5)
The results of the experiments of Examples 1 to 6 and Comparative Examples 1 to 3 (Table 2) show that carbodiimide is superior to Comparative Examples 1 to 3 which do not contain carbodiimide as a wool / hair growth promoting component that is not substituted with a bioreactive group Examples 1 to 6, which contained carbodiimide, exhibited better wool / hair growth improving effects due to the covalent bond formation effect of carbodiimide, and Examples 4 to 6 using polymer carbodiimide showed better wool / hair growth improving effect .
(N = 5, respectively)
(5 points scale)
Formulation example One: Hair care Produce
Hair restorers were prepared by the ingredients and contents shown in the following Table 3 according to a conventional hair restorer manufacturing method.
Claims (9)
Wherein the wool / hair growth promoting component comprises a carboxyl group or an amine group in the molecule.
The wool and hair growth promoting component may be selected from the group consisting of common extracts, capronium chloride, cephalanthin, benzyl nicotinate, l-menthol, estradiol, ethinyl estradiol, pyridoxine hydrochloride, salicylic acid, resorcinol, benzalkonium chloride, A potassium salt or an ammonium salt of glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhetinic acid, glutamate, glycyrrhetinic acid, glycyrrhetinic acid, , Tocopherol / tocopherol acetate, hinokitiol, dexpanthenol, dicyclohexylcarbodiimide hydrochloride, diphenhydramine hydrochloride, dipotassium glycyrrhizinate, pyridoxine dicarboxylate, tricosaccharide, tocopherol / Pantothenyl ethyl ether, sodium pantothenate / calcium, isopropyl ethyl phenol, mononitroguacol, gluconate chlorohexidine solution, Isostearate, ginsenoside, succinic acid, succinic acid, succinic acid, succinic acid, succinic acid, succinic acid, one selected from the group consisting of vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin E, cystine, cysteine, methionine, leucine, tryptophan, glycerin, pyrrolidone carboxylic acid and camphor / RTI > composition for promoting hair and / or hair growth.
Wherein the wool / hair growth promoting component has a functional group capable of being covalently bonded to the hair or the protein residues on the surface of the skin.
The functional group covalently bonded to the protein is selected from imide ester, aryl azide, diazyline, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxy succinimide ester, alkoxyamine, hydrazide, The present invention relates to a process for the preparation of a compound of formula (I) as defined in claim 1, wherein the compound is selected from the group consisting of: haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenylcarbonate, aziridine, isocyanate, thiocyanate, epoxide, At least one member selected from the group consisting of oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone Composition.
Wherein the carbodiimide compound is 0.001 to 10 parts by weight based on 100 parts by weight of the total composition.
A carbodiimide compound and a wool / hair growth promoting component are formulated into a single preparation in an encapsulated form; A carbodiimide compound, and a wool / hair growth promoting component are separated from each other.
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020130152321A KR102006950B1 (en) | 2013-12-09 | 2013-12-09 | Cosmetics compositions for hair growth promoter |
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| KR1020130152321A KR102006950B1 (en) | 2013-12-09 | 2013-12-09 | Cosmetics compositions for hair growth promoter |
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| KR102006950B1 KR102006950B1 (en) | 2019-08-02 |
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| KR1020130152321A KR102006950B1 (en) | 2013-12-09 | 2013-12-09 | Cosmetics compositions for hair growth promoter |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102102578B1 (en) | 2019-06-26 | 2020-04-21 | 코스맥스 주식회사 | Cosmetic composition for strengthening hair bulb comprising mixture of 18β-Glycyrrhetic acid, D-panthenol and Menthol as effective component |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| WO2022015055A1 (en) * | 2020-07-14 | 2022-01-20 | 주식회사 엘지생활건강 | Composition for preventing hair loss and promoting hair growth |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
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| JPS58162511A (en) * | 1982-03-23 | 1983-09-27 | Sakahito Matsuno | Hair nourishing composition |
| JP2005179210A (en) * | 2003-12-17 | 2005-07-07 | Lion Corp | Hair setting agent composition, two-package hair setting agent composition, and composition for hair setting agent |
| KR20080064467A (en) | 2007-01-05 | 2008-07-09 | 주식회사 엘지생활건강 | Mixed-type personal care product for skin or hair |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58162511A (en) * | 1982-03-23 | 1983-09-27 | Sakahito Matsuno | Hair nourishing composition |
| JP2005179210A (en) * | 2003-12-17 | 2005-07-07 | Lion Corp | Hair setting agent composition, two-package hair setting agent composition, and composition for hair setting agent |
| KR20080064467A (en) | 2007-01-05 | 2008-07-09 | 주식회사 엘지생활건강 | Mixed-type personal care product for skin or hair |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| KR102102578B1 (en) | 2019-06-26 | 2020-04-21 | 코스맥스 주식회사 | Cosmetic composition for strengthening hair bulb comprising mixture of 18β-Glycyrrhetic acid, D-panthenol and Menthol as effective component |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11911498B2 (en) | 2020-06-01 | 2024-02-27 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| WO2022015055A1 (en) * | 2020-07-14 | 2022-01-20 | 주식회사 엘지생활건강 | Composition for preventing hair loss and promoting hair growth |
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| Publication number | Publication date |
|---|---|
| KR102006950B1 (en) | 2019-08-02 |
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