KR102006956B1 - Compositions for deodorant - Google Patents

Compositions for deodorant Download PDF

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KR102006956B1
KR102006956B1 KR1020130152361A KR20130152361A KR102006956B1 KR 102006956 B1 KR102006956 B1 KR 102006956B1 KR 1020130152361 A KR1020130152361 A KR 1020130152361A KR 20130152361 A KR20130152361 A KR 20130152361A KR 102006956 B1 KR102006956 B1 KR 102006956B1
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body odor
extract
inhibiting
composition
carbodiimide
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KR1020130152361A
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Korean (ko)
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KR20150010551A (en
Inventor
손성길
이창우
김지현
김태환
강택균
이상민
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주식회사 엘지생활건강
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00Anti-perspirants or body deodorants

Abstract

The present invention relates to a composition for body odor suppression.
The composition for inhibiting body odor according to the present invention contains a body odor inhibiting component having a specific functional group capable of covalently bonding with a protein residue on the skin or hair surface, thereby forming a covalent bond without damaging the skin or hair, thereby semipermanently desired. Provide.

Description

Composition for inhibiting body odor {Compositions for deodorant}

The present invention relates to a reactive body odor inhibiting component and a body odor inhibiting composition having a functional group binding to a protein.

In general, limiting deodorization is applied to the body to suppress the occurrence of human sweat and to suppress the discomfort of the body to cleanse the body, beautify, increase charm, change the appearance, or keep the skin or hair healthy It is intended to be used in a similar way to spraying, scattering, and others.

Related quasi-drugs are defined as having a milder action and are not used for the treatment or prevention of diseases, but do not have a purpose of use, such as affecting the structure and function of the body, compared to cosmetics.

In general, the limiting agent is a product that suppresses the occurrence of sweat, the deodorant may be said to be a product that suppresses the discomfort of the body. However, the unpleasant body odor is caused by the product of the secretion of sweat glands by the microorganisms odor, so the limiting function can also be said to have a odor suppression function by suppressing the sweat causing the unpleasant body odor. Deodorant products, which have been approved as quasi-drugs in Korea to date, are deodorant by name, but can also be called deodorant with restriction functions.

Sweating in the human body is very important in terms of physiological function, but often has a bad effect on the skin. The occurrence of sweat bands, odors, etc. are typical, and it is necessary to prevent the hygiene and cosmetic aspects of the skin.

As a general method of restriction and deodorization, the use of aluminum compounds such as chlorohydroxyaluminum, allantoinchlorohydroxyaluminum and allantoindihydroxyaluminum, zinc p-phenolsulfonic acid zinc, and the like to suppress the occurrence of sweat from eccrine and apocrine glands Inhibition of sweat generation due to astringent action, prevention of body odor by fungicides using benzalkonium chloride, triclosan, chiram and the like, a method of masking odor by use of perfume or odecoron, and the like.

Restrictive and deodorant compositions generally also include some products for cleansing, trimming, and protecting the skin and scalp, bases, points, baths, restraints, deodorization, hair loss, and hair removal. Restrictive and deodorant compositions for hair and scalp first include hair restriction and deodorant products such as cleansing, treatment, hairdressing, perm, hair dyeing, bleaching, and scalp restriction and deodorant products such as wool, hair growth, and treatment. And aromatic deodorant products having functions.

Common raw materials used to formulate such limiting and deodorant products include oily materials such as fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anionic, cationic, amphoteric and nonionic surfactants. It includes high molecular compounds used as moisturizers, thickeners and film-forming agents, ultraviolet absorbers and blockers, antioxidants, metal ion sequestrants, colorants including dyes and pigments, fragrances and preservatives.

Restrictive and deodorant main components may also include aluminum compounds such as chlorohydroxy aluminum, allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, zinc p-phenolsulfonic acid zinc, benzalkonium chloride, triclosan, chiram and flavoring components. Can be. Further active ingredients include zinc oxide, zinc lactate, allatoin hydroxyaluminum, magnesium chloride, aluminum sulfate, sulfo carbonate zinc, tannic acid, citric acid, lactic acid and other astringents, menthol, camphor, etc. Pharmaceutical components such as fresheners, and halo compounds that contain and deodorize odor molecules such as cyclodextrins and derivatives, cucurbityl and derivatives.

Examples of the odor preventing agent include pharmaceutical ingredients for preventing odor, such as restriction agents such as aluminum chloride, potassium aluminum sulfate, and zinc oxide, bactericides such as benzetonium chloride, halocarran and chlorhexidine hydrochloride and deodorants such as zinc oxide.

In addition, the oral medicine may include an oral pharmaceutical component including an anti-odor component such as copper chloropin sodium, a tobacco removal component such as polyethylene glycol, and the like.

However, when used in the skin and the like as the limiting and deodorant ingredients, only a temporary effect is provided until the next cleaning after the treatment, and there is always a hassle to be reprocessed after the cleaning.

Patent document 1 relates to a non-aqueous personal care product for skin or hair, wherein a functional group capable of covalently bonding to protein residues on the hair or skin surface in a non-aqueous part is carbonate, aldehyde, propionaldehyde, Butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide ), Hydroxysuccinimidyl ester, imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, Ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic ester, Group consisting of disulfide, ketone and functional group represented by RX (R is any one selected from the group consisting of alkyl, aryl, aralkyl, ring and unsaturated ring, X is I, Br or Cl) Although it comprises a conditioning component having any one or more selected from the non-aqueous part and the water-based part, and discloses a personal care product for hair or skin, characterized in that the mixture is used immediately before use, but the various functional groups In the case of the target, lysine, which is harmful to the human body or contains a small amount of amino acids in the protein constituting the hair or skin, such as hair (1.9-3.1%) and skin keratin (3.1-6.9%), or hair (16.6) ~ 18%) and the skin keratin (2.3 ~ 3.8%) of the target cysteine to react because the reaction efficiency is reduced and each material There is a problem that must be synthesized.

Korean Unexamined Patent No. 2008-0064467

It is an object of the present invention to provide a composition for inhibiting body odor that can continuously give a semi-permanent body odor inhibitory effect without damaging the skin or hair.

As a means for solving the said subject, this invention provides the composition for body odor suppression containing a carbodiimide type compound and a body odor suppression component.

As another means for solving the above problems, the present invention provides carbodiimide, imido ester, aryl azide, diazirine, hydroxymethyl phosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo- Provided is a reactive body odor inhibiting component having a functional group covalently bonded to a protein of at least one hair or skin surface selected from the group consisting of hydroxysuccinimide ester, alkoxy amine, hydrazide, haloacetyl and azide.

As another means for solving the above problems, the present invention provides a composition for inhibiting body odor comprising the reactive body odor inhibiting component.

The composition for inhibiting body odor according to the present invention contains a reactive body odor inhibiting component and / or a carbodiimide-based compound incorporating a specific functional group capable of covalently binding to protein residues of the skin or hair, thereby preventing covalent bonding without damaging the skin or hair. It forms semi-permanently and provides body odor suppression effect.

The present invention relates to a body odor inhibiting composition comprising a carbodiimide compound and a body odor inhibiting component.

The composition for inhibiting body odor according to the present invention, for example, by reacting a carbodiimide-based compound with a known body odor inhibitory component through a reactive body odor inhibitory component in which a carbodiimide group is bonded to form a covalent bond with the protein of skin or hair By maximizing the body odor suppression effect.

The carbodiimide-based compound may be included in an amount of 0.001 to 10% by weight, 0.01 to 7% by weight, or 0.1 to 5% by weight based on 100% by weight of the total composition. If the content is less than 0.001% by weight, there is a problem in that it is difficult to exhibit a continuous body odor suppression effect, and when it exceeds 10% by weight, the carbodiimide-based compound excessively present beyond the reaction site present in the hair or skin reacts with the hair or skin. There is a problem that can act as a component that does not help to improve the sustainability by reacting with the efficacious substances in the state that is not.

In the present invention, the "odor suppression effect" means a function of preventing the body odor, which is a malodor of a product decomposed by the microorganisms from the secretion of sweat glands, or suppressing the occurrence of sweat that is the cause of the body odor.

Examples of the body odor inhibiting component used in the present invention include chlorohydroxy aluminum, allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum compounds such as aluminum chloride, potassium aluminum sulfate, benzetonium chloride, halocaran, Chlorhexidine hydrochloride, zinc oxide, p-phenolsulfonic acid zinc, benzalkonium chloride, triclosan, chiram, bogolgol extract, brown root extract, gilding extract, kill extract, iris extract, ginkgo biloba extract, bark extract, licorice extract, sewage It may be one or more selected from the group consisting of extract, Echochocho extract, portulaca extract, wood vinegar, bamboo salt, grapefruit extract, green tea extract and peony extract.

Further active ingredients include zinc oxide, zinc lactate, allatoin hydroxyaluminum, magnesium chloride, aluminum sulfate, sulfo carbonate zinc, tannic acid, citric acid, lactic acid and other astringents, menthol, camphor, etc. Pharmaceutical components, such as a refreshing agent, and halo compounds which contain and deodorize odor molecules such as cyclodextrins and derivatives, cucurbityl and derivatives can be used.

In addition, the oral medicine may include an oral pharmaceutical component including an anti-odor component such as sodium chloropin, tobacco removal component such as polyethylene glycol, and the like.

The body odor inhibiting component is preferably used in 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight or 0.1 to 5 parts by weight based on 100 parts by weight of the total composition. The use of less than 0.001 parts by weight has a problem of limiting the performance of performance, and the excess of 50 parts by weight has problems with formulation and formulation stabilization.

In particular, the body odor inhibiting component in the present invention can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.

In addition, the body odor inhibiting component in the present invention may be one having a functional group capable of covalently bonded to protein residues on the skin or hair surface.

The functional group covalently bonded with the protein is carbodiimide, imido ester, aryl azide, diazirine, hydroxymethyl phosphine, pentafluorophenylester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy amine, Hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester , Imidazole, oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone This is not restrictive.

In addition, the protein may include a reactive moiety of thiol, hydroxyl, carboxyl or amine.

The carbodiimide-based compound is a generic term for a compound containing a structure represented by the following formula (1) in a molecule.

[Formula 1]

-N = C = N-

The carbodiimide-based compound preferably includes at least 1 to 1000 structures of Formula 1, more preferably 1 to 100 structures represented by Formula 1 in a molecule, It is more preferable to include 1 to 10 structures represented in the molecule.

In this case, when the number of carbodiimide groups represented by the formula (1) in one molecule exceeds 1000, the viscosity of the raw material is too large, the molecular weight is too large, and the reaction sites that can react too much are excessively large, and The molecule | numerator which has a bodyimide group becomes so large that the problem which efficiency falls by covering the part which shows the functional effect of the molecule which has a substantial function arises.

Specific examples of the carbodiimide-based compound in the present invention may be a compound represented by the following formula (2), n is 4 and m is 11 in the formula (2) is benzene, 1,3, -bis (1- Isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-meth-ether-block (Benzene, 1,3-bis (1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono- Me-ether-blocked) (hereinafter referred to as polymer type carbodiimide compound of Formula 2).

(2)

Figure 112019057797098-pat00005

In Formula 2, n is 1 to 100, m is 1 to 100.

In another embodiment of the carbodiimide-based compound in the present invention, as a compound represented by the following formula (3), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimideHCl) can be used.

(3)

Figure 112013112490353-pat00002

In one preferred embodiment of the composition for inhibiting body odor according to the present invention, the body odor inhibitor component having a carboxyl group is made into a reactive ester body odor inhibitor component having direct bioreactivity, or skin keratin (15.5 to 23.5%) or hair (17.5 to 17.5). 21.9%) ester form (reactive body odor inhibiting component) using a carbodiimide compound that can be targeted by a body odor inhibiting component containing an amine group by reactive esterification of an amino acid (ex, aspartic acid, glutamic acid) in excess By increasing the reaction efficiency can be increased significantly. In addition, carbodiimides, imidoesters, arylazides, diazirines, hydroxymethyl phosphines, pentafluorophenylesters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy, which may target other amino acids The effect can be further enhanced by using a body odor inhibiting component containing a functional group such as amine, hydrazide, haloacetyl, azide in the molecule.

In a more preferred embodiment, the polymer body carbodiimide-based compound of formula (2) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide is first used on the body odor inhibiting molecule molecule having a carboxyl group or on the surface of the protein of skin or hair. Carbodiimide-based compounds such as hydrochloric acid (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl) are first reacted to form a reactive ester, and the body odor inhibiting component having an amine in the molecule again with the formed reactive ester functional group. By reacting with or reacting with amines on the surface of the skin or hair, an excellent body odor inhibitory effect can be obtained. In the reaction, the reaction may be preferably performed at a pH of 2 to 10, more preferably at a pH of 3 to 9, and most preferably at a pH of 4 to 5 in an acidic to weakly acidic aqueous solution. The most reaction efficiency can be increased. The reaction is completed within 1 to 30 minutes.

In the following Scheme 1, the body odor inhibitor component molecule having a carboxyl group was first reacted with a carbodiimide-based compound to form a reactive ester, followed by reaction with an amino acid of a living body having an amine residue to form a covalent bond.

[Reaction Scheme 1]

Figure 112013112490353-pat00003

In the following scheme 2, aspartic acid and glutamic acid, which are biological amino acids having a carboxyl group on the surface of the protein of the skin or hair, are first reacted with a carbodiimide compound to form a reactive ester, followed by reaction with a body odor inhibiting component having an amine residue to form a covalent bond. The reaction schematic to form is shown.

[Reaction Scheme 2]

Figure 112013112490353-pat00004

The carbodiimide compound enhances the reaction efficiency of the skin or hair protein and the body odor inhibiting component, so that the reactive body odor inhibitory component bound to the skin or hair does not fall off well during general washing due to shampoo or soap, The skin or hair can be kept attached.

The present invention also provides carbodiimide groups, imidoesters, arylazides, diazirines, hydroxymethyl phosphines, pentafluorophenylesters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, and alkoxy to body odor inhibitory components. Amine, hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimide At least one selected from the group consisting of dill esters, imidazoles, oxycarbonyl amidazoles, imines, thiols, maleimides, vinylsulfones, ethyleneimines, thioethers, acrylonitrile, acrylic acid or methacrylic acid esters, disulfides and ketones It may include a reactive body odor inhibiting component combined with a functional group covalently bonded to the protein. have.

For example, as in Scheme 1, the carbodiimide group formed by the first reaction of the carbodiimide-based compound may include a body odor inhibiting component bound. In addition, the present invention may include a composition for inhibiting body odor containing the reactive body odor inhibiting component.

Cationization of fatty acids such as palmitic acid and stearic acid, fatty alcohols, long-chain alkyl quaternary ammonium salts such as linear and branched chains, etc. Formulation may be facilitated when used in combination with a cationic polymer such as surfactant, cationic cellulose, cationic guar, cationic polyvinylpyrrolidone, silicone, and the like. In addition, the formulation additionally includes components for the formulation of solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH adjusting agents, metal ion sequestrants, colorants, pearlescent agents, cosmetics, pigments, powder particles, etc. can do. The component for the formulation may be used 40 to 99 parts by weight based on 100 parts by weight of the total composition.

The composition for inhibiting body odor according to the present invention may be used in the formulation of a cosmetic composition for inhibiting body odor including a component of the body odor suppression function having a functional group. Examples of application of skin products generally include skin care, basic cosmetics (cosmetics, serums, essences, lotions, creams), color cosmetics (makeup base, foundation, powder, eye shadow, lip gloss, lipstick, lip balm, etc.) , Makeup for nails (nail polish, nutrients, reinforcing agents, top coats, etc.), cleaning cosmetics (foam cleansing, cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, soap, cleansing tissue, etc.), sun care It can include both cosmetics and body cosmetics (body lotions, shower gels, body creams, body oils, etc.), and even hair, such as shampoos, rinses, treatments, hair packs, hair essences, waxes, gels, sprays, etc. All formulations may be included.

More preferably, the composition for inhibiting body odor according to the present invention comprises a carbodiimide-based compound and at the same time comprises a body odor inhibiting component having a reactive functional group, and when the above agent is deteriorated in water, the non-aqueous formulation It is easier to maintain the activity in the reaction system, and the reaction may be caused by mixing with a buffer for pH control immediately before use or contacting with water during the cleaning process. Examples of non-aqueous formulations include liquid form, sheet form, powder powder form, tablet form, oil, wax, ampoule, gel and the like used as conventional non-aqueous cosmetic preparations. In addition, the carbodiimide-based compound and the body odor inhibiting component may be formulated as a single agent in encapsulated form or as two agents in separate forms, respectively. In addition, a method of blocking derivatives in a form in which a reactive functional group and a component having a body odor inhibiting function are combined with water through encapsulation may also be used.

In order to enhance the body odor inhibitory effect having a functional group in the composition for body odor suppression according to the present invention, 2-basic acid ester oil such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, polyol, polyethylene glycol, propylene glycol , Hexylene glycol, butanediol and their isomers, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The above-mentioned solvents increase the permeability of the skin or hair and are used as solvents of poorly soluble substances. More preferably, the solvent used to increase the activity retention effect of the body odor inhibiting component having a functional group includes diethyl sebacate, ethoxyglycol, bis-ethoxyglycol cyclohexane 1,4-dicarboxylate and the like.

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example  1 and 2 and Comparative Example  One

In the following compositions and contents shown in Table 1 was prepared in Example 1 to 2 and Comparative Example 1 body odor suppression composition, the prepared composition to be used for 10 days of heavy odor subjects twice a day in the armpit three days , The degree of improvement of the odor that was allowed to live as usual for one week was confirmed by sensory on a five-point scale (5 very good, 4 slightly good, 3 no difference, 2 no effect, 1 very no effect).

Category (% by weight) Comparative Example 1 Example 1 Example 2 Distilled water 46.0 43.0 43.0 Thiram 3.0 3.0 3.0 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide. Hydrochloric acid - 3.0 - Benzene, 1,3, -bis (1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-meth-ether-block - - 3.0 Glyceryl Stearate / PEG-100 Stearate 0.5 0.5 0.5 Polysorbate-20 0.5 0.5 0.5 Buffer (pH 4.5) 50.0 50.0 50.0 Sum 100.0 100.0 100.0

Experimental results of Tables 1 to 2 and Comparative Example 1 (Table 2), Examples 1 to 2 containing carbodiimide compared to Comparative Example 1 not containing carbodiimide as a covalent bond forming effect of the carbodiimide Excellent anti-odor effect.

Classification (5-point scale) Comparative Example 1 Example 1 Example 2 Body odor prevention effect 3.0 3.9 4.0

Formulation example : Deodorant  Produce

According to the conventional method for preparing deodorant, the deodorant was prepared using the ingredients and contents shown in Table 3 below.

Component (% by weight) Body odor prevention mist Cheram 1.5 Benzene, 1,3, -bis (1-isocyanato-1-methylethyl)-, homopolymer, polyethylene glycol mono-meth-ether-block 1.0 glycerin 3.0 Carboxyvinyl polymer 0.1 Phage-12 nonylphenyl ether 0.3 Polysorbate 80 0.5 ethanol 7.0 Triethanolamine 0.1 antiseptic Suitable amount Spices Suitable amount Buffer (pH 4.5) Balance Sum 100.0

Claims (9)

A carbodiimide compound represented by the following formula (2); And a body odor inhibitory component comprising a functional group capable of covalently binding to a protein residue on the surface of hair or skin:
(2)
Figure 112019057797098-pat00006

In the above formula (2), n is 1 to 100 and m is 1 to 100.
The method of claim 1,
The body odor inhibiting component is a composition for inhibiting body odor comprising a carboxyl group or an amine group in the molecule.
The method of claim 1,
The body odor inhibiting components include chlorohydroxy aluminum, allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum chloride, aluminum compounds such as potassium aluminum sulfate, benzetonium chloride, halocarrane, chlorhexidine hydrochloride, zinc oxide, p-phenol Zinc sulfonate, benzalkonium chloride, triclosan, chiram, bogolgol extract, brown root extract, gold coin extract, kill extract, iris extract, ginkgo biloba extract, bark extract, licorice extract, sewage extract, eochocho extract, machihyun extract, wood vinegar , Composition for inhibiting body odor which is at least one selected from the group consisting of bamboo salt, grapefruit extract, green tea extract and peony extract.
delete The method of claim 1,
The functional group covalently bonded with the protein is imidoester, arylazide, diazirine, hydroxymethyl phosphine, pentafluorophenylester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxy amine, hydrazide, Haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, hydroxysuccinimidyl ester, imidazole, Oxycarbonyl amidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone composition for inhibiting body odor.
The method of claim 1,
Composition for inhibiting body odor containing a carbodiimide-based compound in 0.001 to 10% by weight in 100% by weight of the total composition.
The method of claim 1,
A composition for inhibiting body odor, wherein the carbodiimide compound and the body odor inhibiting ingredient are formulated as a single agent in an encapsulated form, or the carbodiimide compound and the body odor inhibiting ingredient are formulated as a separate agent, respectively.
delete delete
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WO2002013773A2 (en) * 2000-08-16 2002-02-21 Unilever Plc Cosmetic composition
JP2008187928A (en) * 2007-02-02 2008-08-21 Yaizu Suisankagaku Industry Co Ltd Body odor suppressing composition, and food and drink, cosmetics and washing treating agent containing the same, and body odor suppressing method

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