KR101453217B1 - Cosmetics compositions for humectant - Google Patents

Abstract

The present invention relates to a cosmetic composition for moisturizing. The cosmetic composition for moisturizing according to the present invention provides a desired moisturizing effect semi-permanently because it includes a moisturizing component having a specific functional group which can covalently bond with protein residue on the surface of skin or hair and thereby forms a covalent bond without damage to skin or hair.

Description

[0001] Cosmetics compositions for humectant [

The present invention relates to a reactive moisturizing component and a cosmetic composition for moisturizing to which a functional group binding to a protein is bound.

Generally, moisturizing cosmetics refers to a function that prevents skin damage such as cracks and roughness by keeping normal moisture on human skin or hair, which looks soft and lively. Moisturizing cosmetics are applied to the body in a way similar to those used to moisturize the skin or hair, to increase the attractiveness, to change the appearance, or to keep the skin healthy by maintaining normal moisture on the skin or hair .

It is also defined that quasi-drugs do not have the purpose of use, such as affecting the structure and function of the body, rather than being used for the treatment or prevention of diseases, even though they have an effect on the human body.

Moisturizing cosmetics generally include some of the body moisturizing cosmetics such as foundation moisturizing cosmetics, base, points, nails, makeup moisturizing cosmetics, and cleansing, sun care, sun tanning, etc.

In general, skin, hair and fibers become dry, cracked and rough when the moisture content is low. In addition, the skin surface is scratched and often accompanied by itching. In addition, dry skin is susceptible to bacterial or fungal infections, and skin dryness is often referred to as dry skin. However, when moisturizing the skin, it prevents damage caused by dryness of the skin, and it is possible to protect the skin by preventing the direct exposure of the skin to external contaminants by the thin lipid membrane of the skin surface. In addition, when the skin becomes moist, it looks soft and vivid, and some fine wrinkles may be hidden and the pores may be seen to be small.

These moisturizers are components that maintain the moisture content of the stratum corneum through hydrogen bonding when applied to the skin while being mixed with water. These moisturizers function similar to sebum, moisturizers using natural moisturizing factors, general organic compound moisturizers, ceramides and structural And a moisturizing agent that maintains a layered lamellar form and provides a moisturizing effect.

If you divide the humectant according to function, first, the skin wetting agent having a function similar to the natural moisturizing factor is a substance having strong affinity with water and functions to attract moisture around itself and to retain moisture. The most typical skin moisturizer is glycerin, which penetrates into the stratum corneum and tightly binds to protein or lipid in the stratum corneum, thereby suppressing water loss in the epidermis. However, in a dry environment, wetting agents can absorb moisture from the skin and make the skin more dry, which is less effective than skin sealants. Such skin moisturizing agents include glycerin, propylene glycol, pyrrolidonecarboxylic acid, sodium lactate, urea, and the like.

A skin sealant having a function similar to that of sebum is an oily substance and forms a water-impermeable membrane that does not permeate the skin surface to the skin surface, so that it plays a role similar to that of the normal skin. If the skin is pre-moisturized using a cleanser or the like, the supplied moisture can be retained for a long time and be more effective. A variety of oil components such as mineral oil, vaseline, lanolin, jojoba oil, olive oil, and lipid mixture are used as the substances used as the skin millephea. Some skin sealants, however, are sticky and greasy, which may indicate discomfort when used or after use.

Recently, the importance of intercellular lipids in the stratum corneum has been emphasized, and researches and commercialization of moisturizing ingredients containing ceramides have been progressing. As a result, it has been confirmed that when mixed with ceramide, cholesterol, and fatty acid at a proper ratio and applied to the skin, the damaged skin is restored and has a moisturizing function.

In addition, studies on increasing the moisturizing effect through the structure such as emulsion or lamellar layer structure are progressing much. In fact, moisturizing agent of W / O type is more effective than O / W type moisturizing agent, O / W moisturizing products are sold many because of feeling.

Common raw materials used to formulate these moisturizing cosmetics include oily materials such as oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils and silicone oils, anions, cationic, amphoteric and nonionic surfactants, Antioxidants, metal ion sequestrants, coloring materials including dyes and pigments, fragrances, preservatives, and the like can be given as examples of the antioxidants.

However, when such a moisturizing ingredient is applied to the skin, it only provides a temporary effect until the next washing after the treatment, but there is always the hassle of reprocessing after cleaning.

Patent Document 1 discloses a non-aqueous personal care product for skin or hair, which comprises a non-water-based functional group capable of forming a covalent bond with a hair or a protein residue on the surface of a skin, such as carbonate, aldehyde, propionaldehyde, But are not limited to, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, A hydroxysuccinimidyl ester, an imidazole, an oxycarbonylamidazole, an imine, a thiol, a maleimide, a vinylsulfone, For example, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic ester, (Wherein R is any one selected from the group consisting of alkyl, aryl, aralkyl, cyclic and unsaturated rings, and X is I, Br or Cl) represented by the following formula And a water-based part containing a conditioning component having at least one selected from the group consisting of the above-mentioned various kinds of functional groups, (1.9 to 3.1%) and skin keratin (3.1 to 6.9%) in the amino acids of the proteins constituting the hair or the skin, ~ 18%) and skin keratin (2.3 ~ 3.8%) are targeted and reacted, so that the reaction efficiency is lowered. There is a problem in that it must be synthesized.

Korean Patent Publication No. 2008-0064467

An object of the present invention is to provide a cosmetic composition for moisturizing which is capable of continuously imparting a semi-permanent moisturizing effect without damaging the hair or skin.

As means for solving the above problems, the present invention provides a cosmetic composition for moisturizing comprising a carbodiimide compound and a moisturizing component.

As another means for solving the above-mentioned problems, the present invention provides a cosmetic composition containing as a moisturizing component at least one selected from the group consisting of carbodiimide, imidoester, aryl azide, diazyline, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, At least one hair selected from the group consisting of ricosuccinic imide ester, alkoxyamine, hydrazide, haloacetyl, and azide, or a functional group covalently bonded to a protein on the surface of the skin.

As another means for solving the above problems, the present invention provides a cosmetic composition for moisturizing comprising the above-mentioned reactive moisturizing component.

The moisturizing cosmetic composition according to the present invention contains a reactive moisturizing component and / or a carbodiimide compound into which a specific functional group capable of covalently bonding with a hair or skin protein residue is incorporated, thereby forming a covalent bond without damaging hair or skin To provide a semi-permanent moisturizing effect.

The present invention relates to a cosmetic composition for moisturizing comprising a carbodiimide compound and a moisturizing component.

The moisturizing cosmetic composition according to the present invention can be prepared by, for example, reacting a carbodiimide compound with a known moisturizing component to form a covalent bond with a hair or skin protein through a reactive moisturizing component to which a carbodiimide group is bonded, Can be maximized.

The carbodiimide compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the entire cosmetic composition. When the content of the carbodiimide compound is less than 0.001 part by weight, there is a problem that the continuous moisturizing effect is hardly exhibited. When the content exceeds 10 parts by weight, the carbodiimide compound, which exists excessively above the reaction site existing in the skin, And thus can not function to improve persistence and can act as a lost component.

In the present invention, the term 'moisturizing effect' refers to a function of preventing skin damage such as cracking and roughness by keeping normal moisture in human skin or hair and thus appearing to be soft and vivid.

The moisturizing component used in the present invention may include a moisturizing component that can fill skin or hair damaged areas such as extracts derived from natural products such as copper, plants and minerals, amino acids, peptides, proteins, saccharides, vitamins and the like. It is not limited. Examples of the solvent include glycerin, propylene glycol, butylene glycol, dipropylene glycol, caprylyl glycol, diglycerol, methylglucose, ethoxydiglycol, glycerol, propanediol, diethoxydigly But are not limited to, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, Chitosan, chitosan succinamide, vitamin E (tocopherol), urea, hydroxy, carboxymethyl chitin, ceramide, glucosyl ceramide, glycosaminoglycan, alpha-glucan, hyaluronic acid, hydrolized hyaluronic acid, Ethyl urea, glucosides, gamma PGA, xylityl glucoside, xylitol, pentaerythritol tetraisostearate, sodium chondroitin sulfate, Sodium polygamma-glutamate, polyglutamic acid, glyceryl polyacrylate, galactoarabanane, polyglycerin-3, polyglycerol-3, But are not limited to, crosspolymer, sodium hyaluronate, bis-phage-18 methyl ether dimethylsilane, bis-ethoxydiglycol stearate, lecithin, ascorbyl tetraisopalmitate, glycosyltrehalose, Citrate, glycogen, histidine HCI, alanine, threonine, glutamic acid, lysine HCI, phosphate buffered cellulain, creatine, cholecysteine, Stearyl isostearate, cholesteryl chloride, cholesteryl nanoate, VITECH, sodium diureamidoglutamide Shin, maltodextrin, polyquaternium -39, Collet knife when not fetch rolpi -12 ethers, saccharide iso Murray rate, sorbitol, and be at least one selected from the group consisting of their derivatives.

The moisturizing component is preferably used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight based on 100 parts by weight of the total cosmetic composition. If the content is less than 0.001 part by weight, there is a problem of effective performance limit. If the content is more than 50 parts by weight, there is a problem in formulation and formulation stabilization.

Particularly, in the present invention, the moisturizing component can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.

In addition, in the present invention, the moisturizing component may be one having a functional group capable of covalent bonding with the hair or the protein residues on the skin surface.

The functional groups covalently bonded to the protein include carbodiimide, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy amines, The present invention also relates to a process for the preparation of a medicament for the treatment and / or prophylaxis of a disease or condition selected from the group consisting of hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenylcarbonate, aziridine, isocyanate, thiocyanate, epoxide, May be at least one selected from the group consisting of imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone , But is not limited thereto.

In addition, the protein may comprise reactive residues of thiol, hydroxyl, carboxyl or amine.

The carbodiimide compound is generally referred to as a compound containing a structure represented by the following formula (1) in the molecule.

[Chemical Formula 1]

-N = C = N-

The carbodiimide compound preferably has at least 1 to 1000 structures represented by the formula (1), more preferably 1 to 100 structures represented by the formula (1) It is more preferable that the structure includes 1 to 10 structures in the molecule.

In this case, if the number of the carbodiimide groups represented by the formula (1) exceeds 1,000 in one molecule, the viscosity of the starting material is too large, the molecular weight is excessively large, the reaction position where the reaction can be performed becomes excessively large, The molecule having the bodymide group becomes too large, and the efficiency is lowered by blocking the portion showing the functional effect of the molecule having the substantial function.

In the present invention, a specific example of the carbodiimide compound may be a compound represented by the following formula (2), wherein n is 4 and m is 11 in the following formula (2): benzene, 1,3, Isocyanato-1-methylethyl) -, homopolymer, polyethylene glycol mono-ether-block (benzene, 1-isocyanato- Me-ether-blocked (hereinafter referred to as polymeric carbodiimide compound of formula (2)).

(2)

In the above formula (2), n is 1 to 100 and m is 1 to 100.

Another example of the carbodiimide compound in the present invention is 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide, which is a compound represented by the following formula (3) carbodiimide or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl may be used.

(3)

In one preferred embodiment of the moisturizing cosmetic composition according to the present invention, the moisturizing component having a carboxyl group is directly made into a reactive ester moisturizing component having a bioreactivity, or hair (17.5 to 21.9%) and skin keratin (15.5 to 23.5% (Ex., Aspartic acid, glutamic acid) are reactively esterified to produce a reactive ester form (reactive moisturizing component) by using a carbodiimide compound capable of targeting a moisturizing component including an amine group By increasing the efficiency, the effect can be significantly increased. In addition, it is also possible to use carbodiimides, imidoesters, aryl azides, diazylines, hydroxymethylphosphines, pentafluorophenyl esters, pyridyl disulfides, sulfo-hydroxysuccinimide esters, alkoxy The effect can be further enhanced by using a moisturizing component containing a functional group such as amine, hydrazide, haloacetyl, or azide in the molecule.

As a more preferable embodiment, a polymeric carbodiimide compound of formula (2) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide is firstly added to the surface of the skin or hair of a moisturizing molecule having a carboxyl group. A carbodiimide compound such as 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide.HCl is firstly reacted to form a reactive ester, and a moisturizing component having an amine in the molecule again to the reactive ester functional group formed is reacted Or by reacting with the amine on the surface of hair or skin, an excellent moisturizing effect can be obtained. The reaction is preferably carried out at a pH of 2 to 10, more preferably at a pH of 3 to 9, most preferably at an acidic to slightly acidic pH of about 4 to 5 The reaction efficiency can be increased most. The reaction is completed within 1 minute to 30 minutes.

In the following Reaction Scheme 1, a hydration component molecule having a carboxyl group is firstly reacted with a carbodiimide compound to form a reactive ester, and then a covalent bond is formed by reacting with an amino acid of a living body having an amine residue.

[Reaction Scheme 1]

In the following Reaction Scheme 2, asparaginic acid and glutamic acid, which are bioamino acids having a carboxyl group on the surface of a hair or skin protein, first react with a carbodiimide compound to form a reactive ester, and then react with a moisturizing component having an amine residue to form a covalent bond .

[Reaction Scheme 2]

The carbodiimide compound increases the reaction efficiency of the hair or the skin protein and the moisturizing component so that the reactive moisturizing component bound to the hair or the skin does not fall off well during the general washing due to the shampoo or soap, The skin can be kept attached to the skin.

The present invention also relates to a cosmetic composition comprising a moisturizing component and at least one member selected from the group consisting of a carbodiimide group, an imidoester, an aryl azide, a diazirine, a hydroxymethylphosphine, a pentafluorophenyl ester, a pyridyl disulfide, a sulfo-hydroxysuccinimide ester, , Hydrazide, haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tresylate, succinimide, At least one protein selected from the group consisting of ester, imidazole, oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone And a reactive moisturizing component having a functional group covalently bonded thereto.

For example, as shown in Scheme 1, a carbodiimide compound may be combined with a carbodiimide group to form a moisturizing component. In addition, the present invention may include a moisturizing cosmetic composition containing the above-mentioned reactive moisturizing component.

In order to increase the secondary effects of the cosmetic composition for moisturizing according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, and cationic quaternary alkyl quaternary ammonium salts such as linear and branched long chain alkyl quaternary ammonium salts When mixed with a cationic polymer such as a surfactant, cationized cellulose, cationic guar, cationized polyvinylpyrrolidone, silicone, etc., formulation can be facilitated. In order to formulate cosmetics such as solvents, surfactants, thickeners, stabilizers, preservatives, coloring agents, pH adjusters, metal ion sequestering agents, coloring agents, pearlizing agents, external appearance improvers, pigments and powder particles, Components may be incidentally included. The ingredients for the formulation may be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the total composition.

The cosmetic composition for moisturizing according to the present invention can be used for the formulation of a moisturizing cosmetic composition containing a component having a moisturizing function having a functional group. Examples of applications of skin products include cosmetics (such as lotion, serum, essence, lotion, cream), color cosmetics (makeup base, foundation, powder, eye shadow, lip gloss, lipstick, lip balm, etc.) (Cleansing lotion, cleansing cream, cleansing gel, pack, mask, soap, cleansing tissue, etc.), sun care Hair cosmetics, body cosmetics (body lotion, shower gel, body cream, body oil, etc.), and the hair can also contain shampoo, rinse, trimming, hair pack, hair essence, wax, All preparations may be included.

More preferably, the moisturizing cosmetic composition according to the present invention contains a carbodiimide compound and at the same time a moisturizing component having a reactive functional group. When the activity of the above preparation is lowered in a water-based form, It may be easier to maintain, and the pH may be adjusted immediately prior to use by mixing with a buffer, or by contacting the water with the water during the washing process. Examples of non-aqueous formulations include liquid, sheet, powder, tablet, oil, wax, ampoule, gel and the like which are used as ordinary non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the moisturizing component can be formulated into a single preparation in an encapsulated form or a two-component form, respectively. In addition, a method of blocking a derivative in which a functional group having a reactivity and a component having a moisturizing function are combined through encapsulation from moisture can also be used.

In order to enhance the moisturizing effect of the cosmetic composition for moisturizing according to the present invention, it is preferable to use a mixture of a 2-base acid ester oil such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, a polyol, a polyethylene glycol, Hexylene glycol, butanediol, and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof. The above-mentioned solvents increase the permeability of hair or skin and are used as a solvent of a poorly soluble substance. More preferably, the solvent used to increase the activity maintaining effect of the moisturizing component having a functional group is diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example  1 to 7 and Comparative Example  1-3

The moisturizing compositions of Examples 1 to 7 and Comparative Examples 1 to 3 were prepared by the compositions and contents shown in the following Table 1, and 10 g of each of the prepared compositions was applied to ten 5-g hair tresses for each example, The reaction was allowed to proceed, the reaction was firstly rinsed with flowing water, washed with a 15% aqueous solution of sodium laureth sulfate, dried and treated once. Then, 1 g of hair was taken and the amount of moisture was measured at 60 ° C by using a drying weight loss scale. The hair was washed with 15% aqueous solution of SLES and dried, and then the hair was washed 10 times. Moisture content was measured at 60 ℃ using a drying weight loss scale.

Category (% by weight) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Distilled water 49.0 49.0 49.0 49.0 48.0 48.0 48.0 48.0 48.0 48.0 Hyaluronic acid 1.0 - - - 1.0 - - 1.0 - - Chondroitin-4-sulfate - 1.0 - - - 1.0 - - 1.0 - Chitosan - - 1.0 - - - 1.0 - - 1.0 Hyaluronic acid-imido ester - - - 1.0 - - - - - - 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride - - - - 1.0 1.0 1.0 - - - Benzene, 1,3, -bis (1-isocyanato-1-methylethyl) -, homopolymers, polyethylene glycol mono-ether- - - - - - - - 1.0 1.0 1.0 The buffer (pH 8.5) - - - 50.0 - - - - - - The buffer (pH 4.5) 50.0 50.0 50.0 - 50.0 50.0 50.0 50.0 50.0 50.0 Sum 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0

Experimental results of the above Examples 1 to 7 and Comparative Examples 1 to 3 (Table 2) show that a derivative in which a bioreactive group-substituted moisturizing component is substituted for a bioactive reactive group as compared to Comparative Examples 1 to 3 which does not contain carbodiimide Examples 2 to 7 containing the carbodiimide without substituting the bioreactive group exhibited better moisturizing and durability due to the covalent bond formation effect of the carbodiimide And in particular, Examples 5 to 7 using the polymeric carbodiimide showed the most excellent moisturizing and moisturizing effect.

Moisture content
(%) Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Immediately after processing
(Once shampoo) 10.3 10.7 10.6 15.3 15.8 15.8 15.3 16.4 16.8 16.3 Processing 10 times after processing 10.5 10.6 10.8 15.0 15.2 15.3 15.2 15.9 16.0 16.2

Formulation example  1: moisturizing hair  Lotion manufacturing

According to the conventional cosmetic preparation method, a moisturizing cosmetic composition was prepared with the ingredients and contents shown in Table 3 below.

Component (% by weight) Hair lotion Hyaluronic acid 1.0 Chondroitin-4-sulfate 1.0 Benzene, 1,3, -bis (1-isocyanato-1-methylethyl) -, homopolymers, polyethylene glycol mono-ether- 2.0 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxyvinyl polymer 0.1 Polysorbate 60 1.5 Sorbitacecequioleate 1.5 Liquid paraffin 0.5 Caprylic / capric triglyceride 5.0 Triethanolamine 0.1 Cetearyl alcohol 5.0 antiseptic Suitable amount Spices Suitable amount The buffer (pH 4.5) Balance Sum 100

Claims (9)

A carbodiimide compound represented by the following formula (2); And a moisturizing component:
(2)

In the above formula (2), n is 1 to 100 and m is 1 to 100.
The method according to claim 1,
Wherein the moisturizing component comprises a carboxyl group or an amine group in the molecule.
The method according to claim 1,
The moisturizing component may be at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, capryllyl glycol, diglycerol, methylglucose, ethoxydiglycol, glycereth, propanediol, diethoxydigly But are not limited to, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, Chitosan, chitosan succinamide, vitamin E (tocopherol), urea, hydroxy, carboxymethyl chitin, ceramide, glucosyl ceramide, glycosaminoglycan, alpha-glucan, hyaluronic acid, hydrolized hyaluronic acid, Ethyl urea, glucosides, gamma PGA, xylityl glucoside, xylitol, pentaerythrityl tetraisostearate, sodium chondroitin sulfate, cone But are not limited to, lactose-4-sulfate, atelocollagen, beta glucan, PEG, pyridoxine tris-hexyldecanoate, potassium PCA, sodium polygamma- glutamate, polyglutamic acid, glyceryl polyacrylate, galactoarabenane, polyglycerin -3 crosspolymer, sodium hyaluronate, bis-phage-18 methyl ether dimethyl silane, bis-ethoxydiglycol stearate, lecithin, ascorbyl tetraisopalmitate, glycosyl trehalose, hydrogensilide star Threonine, glutamic acid, lysine HCI, phosphate buffered celluloses, phosphate buffered saline, glycerol, glycerol, glycerol, glycerol, Creatine, cholesteryl isosate, cholesteryl chloride, cholesteryl nanoate, Vie tea, sodium diureamidoglutarate Id lysine, maltodextrin, polyquaternium -39, Collet knife when not fetch rolpi -12 ethers, saccharide iso Murray rate, sorbitol and a selected one or more cosmetic composition for moisturizing from the group consisting of their derivatives.
The method according to claim 1,
Wherein the moisturizing component has a functional group capable of being covalently bonded to a hair or a protein residue on the skin surface.
5. The method of claim 4,
The functional group covalently bonded to the protein is selected from imide ester, aryl azide, diazyline, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxy succinimide ester, alkoxyamine, hydrazide, The present invention relates to a process for the preparation of a compound of formula (I) as defined in claim 1, wherein the compound is selected from the group consisting of: haloacetyl, azide, carbonate, aldehyde, propionaldehyde, butylaldehyde, nitrophenylcarbonate, aziridine, isocyanate, thiocyanate, epoxide, At least one selected from the group consisting of oxycarbonylamidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, acrylic acid or methacrylic acid ester, disulfide and ketone.
The method according to claim 1,
Wherein the carbodiimide compound is 0.001 to 10 parts by weight per 100 parts by weight of the total composition.
The method according to claim 1,
A carbodiimide compound and a moisturizing component in the form of an encapsulated single agent; Wherein the carbodiimide compound and the moisturizing component are separated from each other.
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