CN105813626B - Composition containing carbodiimide compound - Google Patents

Abstract

The present invention relates to a kind of coloring composition containing carbodiimide compound, moisture-keeping cosmetic composition, nurse apply some make up composition, ultraviolet blocking-up composition and raw body bonding composition.Composition according to the present invention contains effective component, the effective component has the particular functional group that covalent bond can be formed with the residue of protein of skin, hair or fiber surface, therefore, it can be provided in the case where not damaging skin, hair or fiber surface, covalent bond is formed, thus the semipermanent effect needed for providing.

Description

Composition containing carbodiimide compound

Technical field

The present invention relates to a kind of coloring composition containing carbodiimide compound, moisture-keeping cosmetic composition, Toiletry composition for hair care, ultraviolet blocking-up composition and raw body bonding composition.

Background technique

In general, hair-dyeing agent, that is, hair dye, can be by according to the durability of coloring color and the characteristic of composition It is divided into permanent hair-dyeing agent (oxidative hair dyes), semipermanent hair-dyeing agent (non-oxidative hair dye) and short time Toner.In the case where oxidative hair dyes, the oxidation dye or pigment of low molecular weight occur in hair aoxidize neutralization reaction and Pigment is formed, so as to obtain diversified color, due to excellent hair dyeing, being the hair dye being widely utilized One kind.This oxidative hair dyes composition is oxidized by oxidant, more than one for forming dyestuff or pigment are contained Dyestuff or pigment presoma and more than one couplants, still, this oxidising dyeing hair coloring preparation composition are being suitable for hair Before, it needs to be used in mixed way with oxidants such as dilution hydrogenperoxide steam generators.It is in this way using the purpose of hair dye, hair is use up It may dye completely, also, long lasting for hair dyeing effect.In addition, non-oxidative hair dye is as can will be close to the day of primary colors Right color is provided in the useful hair dye of hair, fewer to the damage of hair, and can carry out together with hair-waving, applies Degree is gradually expanded.But presently commercially available hair dye, it is light tone system, in dyeing, is easy because shampoo repeatedly rinses Fade equal metachromatisms, in particular, in the case where oxidative hair dyes, under the influence of the oxidants such as hydrogen peroxide, In the decolorization of hair, the cystine linkage (S-S) of hair is destroyed, and seriously damages hair, is had compared to healthy hair quality, dyeing The sense of touch of hair reduces, hair lacks moist disadvantage.

In general, moisturizing cosmetic refers to the normal moisture of the skin or hair etc. that maintain people, it is allowed to soft and aobvious Animando is obtained, has the function of preventing the cosmetics of bifurcated, coarse equivalent damage.This moisture-keeping cosmetic, by skin with And hair maintains normal moisture, beautifying skin or hair, increases glamour, changes appearance, alternatively, the skin in order to maintain health Skin to smear, dissipates deposited and other similar method use.In addition, medicine part outer article is defined as: even if having shadow to human body It rings, influences slightly, to be not used to the treatment or prevention of disease, and do not have the mesh of the construction and function that influence body 's.

Moisturizing cosmetic generally includes, and improves, protects basic moisturizing cosmetic, foundation cream, the part use of skin (POINT), manicure is used, color make-up moisturizing cosmetic and is cleaned, sun-proof isolation, the production of the bodies moisturizing cosmetic such as sunbath Product.

In general, the case where skin, hair and fiber, when its moisture content reduces, when for skin, dry, split, It is roughening.In addition, there is skin effect phenomenon in skin surface, while with itch.In addition, dry skin is easy to be by bacterium or true Bacterium infection is referred to as xerodermia having dry skin situation very serious.But when for skin moisture-keeping, skin is prevented Because damaging caused by drying, the thin lipid film of skin surface prevents skin to be directly exposed in external contamination substance, to protect Sheath skin.In addition, skin wet, then limber up, just looks at like vibrant, achieve the effect that hiding fine wrinkles, pore become smaller.

This moisturizer can be divided into following several: containing the ingredient for being easy to mix with water, lead to when being applied on skin Cross the moisture content that Hydrogenbond maintains cuticula, have with the moisturizer of sebum similar functions, utilize natural moisturizing factor function Can moisturizer, general organic compound moisturizer, ceramide and maintain structure on be layer structure platelet morphology, from And reach the moisturizer of moistening effect.

According to function distinguishing moisturizer, firstly, being and water with actie skin moisturizer that natural moisturizing factor has similar functions Divide the substance with strong compatibility, the moisture of own circumference can be adsorbed, to reach the function of maintaining moisture.Wherein, most To be glycerol with the actie skin moisturizer for representing meaning, glycerol penetrates into cuticula, with the protein or lipid shape in cuticula At firm combination, to inhibit the moisture lost from epidermis.But under dry environment, wetting agent absorbs water from skin Point, so that skin becomes more dry, compared to closed dose of skin, effect is worse.This actie skin moisturizer can be enumerated, Glycerol, propylene glycol, 2-pyrrolidone-5-carboxylic acid, sodium lactate, urea etc..

With being to form impermeability on a skin surface by lipid substance with closed dose of the skin of sebum similar functions Film plays the similar effect of the sebum film of normal skin.By wash one's face etc. supplied moisture to skin in advance in the state of make With can then maintain moisture, and then better effect for a long time.As closed dose of substance used of skin, can enumerate, paraffin A variety of oil components such as oil, vaseline, lanolin, Jojoba Oil, olive oil, lipid mixture.But closed dose of some skins In the case where, sticky, greasy, in use or sense of making troubles after.

In recent years, the lipid in cuticula between horn cell shows its importance, for the moisturizing containing ceramide at Divide and carries out numerous studies and commercialization.As a result, ceramide, cholesterol, the fatty acid of mixing proper proportion, are applied to skin When on skin, impaired skin can be restored, and confirmed there is moisturizing.

In addition to this, it is had conducted extensive research to by the increasing moistening effect such as lotion or lamellar structure, in fact, phase It is examined than in the moisturizer of O/W type, the effect of the moisturizer of w/o type is more excellent, but from the property and use feeling easy to manufacture of product Consider, the moisturizer sale of O/W dosage form is more.

Formulation for this moisturizing cosmetic, used conventional raw material can enumerate grease, wax, hydrocarbon, advanced rouge Oiliness raw material, anion, cation, amphoteric ion, nonionic surface active agent, the guarantors such as fat acid, higher alcohol, ester oil, silicone oil Humectant, tackifier and the high-molecular compound used as peel-forming agent, ultraviolet radiation absorption and blocking agent, antioxidant, Metal ion blocks agent, the toner containing dyestuff and pigment, fragrance, preservative etc..

However, these moisturizing ingredients provide of short duration moisturizing effect for being arrived in the case where skin after treatment during cleaning Fruit needs to handle again, cause comparatively laborious after cleaning.

In general, nursing applies some make up and assigns the excellent characteristic such as smooth, soft, elastic, calm to skin and hair, thus Beautifying skin or hair, change appearance at enhancing glamour, alternatively, hair and skin in order to maintain health, to smear, dissipate and smear And similar method is for for the purpose of body.In addition, medicine part outer article is defined as: even if having an impact to human body, shadow It rings slightly, is not used to the treatment or prevention of disease, the use purpose without the structure and function for influencing body.

Nursing, which applies some make up, to be generally included, basic nursing cosmetics, the foundation cream, part use for improving, protecting skin and hair (point), manicure use, color make-up with nursing cosmetics and clean, it is sun-proof isolation, daylight with etc. body cares cosmetics production Product.

Nursing refers to, when some product is related to the amendment of particular side relevant to improved surface damage or pre- When anti-, in particular, the surface quality for being applicable in Cucumber is considered as nursing the case where promotion.

Illustrate by taking hair as an example, the lasting management process of the nursing need of hair.It is well known that hair is by surviving in skin The cell die substantially that a few cell of skin surface depths derives from.Therefore, hair nursing ingredient is to the growth of cell without real Influence in matter or not the underlying repairing of cell.Therefore, the characteristic that damaged hair is improved in the short time, after being released from, Need to be applicable in the nursing of hair again.

Due to physical treatment or the damage of hair caused by being chemically treated, the physical structure for inducing hair change.Although shield Reason ingredient cannot cure the root cause problems of hair, can be with short time poppet before washing away elimination care agent using remover The makeup of hair is worth and function.

Most hair damage the reason is that, hair washing, drying for the purpose of beauty, comb hair, moulding, nursing, hair-waving etc. Caused by the environmental factors such as exposure, sunlight, atmosphere pollution, wind, seawater and the chlorination swimming place of hairdressing habit and chemical substance. Nursing is the original by reducing electrostatic, improving the variforms such as radiation, the increase gloss of hair intensity, protection from ultraviolet light Reason can promote the makeup value of the hair of swelling.

The nursing of hair is to reduce the fracture and porosity of hair, by increasing intensity and gloss, can alleviate hair Damage.Cationic high-molecular conditioner directly participates between high molecular polymer and hair surface between opposite charges because of it The compatibilities of electric interactions be therefore very effective nursing compositions.Conditioner usually stays in the surface of hair tresses, reduces Frictional force and electrostatic phenomenon caused by comb is sent out can be assigned and strengthen elasticity, maintain curling, hair in addition, in another system It is fluffy, the characteristics such as it is easy to arrange.

Nearest conditioner provides one or more of following functions: can be sent out with dewing and drying hair provides easy cardability, fills out The damaged part for filling hair is rearranged and provides soft, porosity and minimize, assign gloss to hair, to assign silk Sense of touch as matter, the defencive function to heat and mechanical damage is provided, assign moisturizing, elasticity and hair more than feeling, eliminate The functions such as electrostatic.

In general, the hair crust (cuticle) of people is made of the cell (dandruff) of average overlapping.Deckzelle is as roof Tile be equally attached to the root to end of hair fiber.Each exodermis is about 0.3~0.5 μ m-thick, wherein visible outer Skin portion is about 5-10 μm degree.The crust of the hair of people is usually 5~10 layers.Each deckzelle of hair is by upper table Skin, A- layers, a variety of sublayers (sublamella) and cell membrane complexes (the cell membrane such as exocuticle, endepidermis, internal layer Complex it) constitutes.Outermost upper epidermal layer is covered by the lipid (fatty acid) of covalent bond, and most in ingredient is 18- Methyl arachic acid (18-Methyl Eicosanoic Acid, 18-MEA).This layer constitutes the outer of deckzelle membrane complex Wide layer plays the role of lubrication, reduces friction, forms hydrophobic surface.

For hair, leak part outside scalp and be called hair shaft, the part according to the service life and length of hair and It changes.In addition, according to the case where having hair cut or having one's hair wash or using hair dryer, the situation of comb hair, hair-waving, hair dyeing etc., dry, Ultraviolet light, seawater, swimming place the environmental factors such as pulverized limestone and change.In particular, for the hair scale piece of dry periphery, even if not It is directly affected by external environment, can be also damaged in the case where multiple accumulation.Impaired hair is that the end of hair scale piece is emerged, Either a part is stripped and carries out one layer and fall off.Light scattering occurs for such hair, therefore lackluster, also not smooth. Impaired bigger when hair, hair scale lamella is fallen completely, internal fur rouge exposure, final hair bifurcated, or is easy disconnected hair.

As above, 18-MEA tries to carry out various processing to improve the surface of damaged hair, so sell in the market or Person improves hair nursing effect by beauty salon hair waxing or the hair essence etc. on probation for smearing hair surface using silicon Product, in also more recently commercialization about the product for assigning skin or hair nursing effect.

But in the case where using this nursing compositions on skin and hair, arrives during cleaning, provide after treatment Of short duration effect needs to handle again, cause comparatively laborious after cleaning.

Usual ultraviolet blocking-up refers to, the ultraviolet light of exposure from life, protect skin or hair of people etc. or Fiber etc., to prevent UV-induced evils and damage.

Ultraviolet light usually dissipates the electric wave of 100~400nm, the electric wave short from wavelength, be divided into vacuum ultraviolet (100~ 190nm), UVC (190~280nm), UVB (280~320nm), UVA (320~400nm).Wherein, the purple that sunlight is included In outside line, the ultraviolet light that can arrive at ground surface is the long wavelength part and UVA of UVB, the outermost skin of human body is constituted, because of purple Outside line and by various injuries.Shortwave UVB epidermis occur absorb and it is at random, to biology injury it is big, cause very in epidermis More acute injuries.Compared to this, long wave UVA is small to the injury of biology, is not concerned with the injury to skin up to now.But The influence for the UVA for including in sunlight can not ignore.In addition, subcutis is reached during UVA penetrates to the skin, because This, directly affecting for ultraviolet light about skin corium is considered as being referred to as the chronic uv damage of light aging.

Compare UVA and UVB, there is that high amount is up to standard in UVA, but uitraviolet intensity is weak, permeates epidermis and skin corium, thus Lead to skin melanism, destroying collagen, elastin laminin etc. influences the ingredient of skin elasticity, becomes the original of skin aging (wrinkle) Cause, although the earth's surface amount of reach of UVB is relatively shorter than UVA, uitraviolet intensity is big, most of that scatter reflections occurs on epidermis, But causes erythema and inflammation, the abnormal keratinization phenomenon of skin occurs.

In general, the barrier effect of ultraviolet light is indicated by SPF (Sun Protection Factor), SPF=uses ultraviolet light Block the MED/ of the skin of product that the MED that ultraviolet light blocks the skin of product is not used；

MED (Minimal Erythma Does- causes minimum amount of ultraviolet (time) needed for erythema).But exposure Cause the time of erythema difference due to weather, ethnic group and different people under ultraviolet light, but in the case where letter state, summer MED is about 10~30 minutes.SPF refers to the degree for preventing from causing because of ultraviolet light erythema to occur, and refers mainly to the effect for blocking UVB. This is to smear the product of SPF high, when exposing in the sun, then has the UVA influenced greatly relative to skin melanism and aging For, it may be possible to exposure in the case where no any defence.Therefore, it is necessary to prepare that both there is high SPF, also can effectively hinder The product of disconnected UVA is vital.The barrier effect of UVA indicated using PA+, PA++, PA+++, be by following formula into Row calculates.

PFA=blocks the MPPD of the skin of the unused ultraviolet light blocking product of MPPD/ of the skin of product using ultraviolet light, Herein, MPPD (Minimal Persistent Pigment Darkening Dose) is that minimum needed for causing melanism is held The timely melanism amount (time) of ideotype.This is different from SPF, it is difficult to and it is shown using specific value, therefore is divided into a certain range to indicate, That is, PFA2 less than 4 (PA+)-have UVA barrier effect, PFA4 less than 8 (PA++)-UVA barrier effects very well, PFA8 (PA+++)-UVA barrier effect is very good above.

By UV-induced skin damage can be divided into sunburn, erythema, melanism (timely type melanism, retarded type melanism), The chronic injuries such as the acute injuries such as immunosupress and light aging, cutaneum carcinoma.

Under normal conditions, UV blockers can be divided into: the ultraviolet radiation absorption of the compound with double bond in the molecule Agent, at random dose of ultraviolet light, resinae and macromolecule peel-forming agent.It is described in the molecule with double bond compound by When ultraviolet light, the energy level of intramolecular electronics rises, and becomes excited state, to absorb ultraviolet light, as this kind of ultraviolet radiation absorptions Agent is just like ultraviolet absorbing agents such as p-aminobenzoic acid, cinnamic acid derivative, salicyclic acid derivatives, methanone derivatives.It is described At random dose of ultraviolet light makes ultraviolet light that the at random of physics occur, so that ultraviolet light is not directly contacted with skin, if any titanium oxide, zinc oxide Equal at random dose of ultraviolet lights.The resinae and macromolecule peel-forming agent for the purpose of increasing water resistance, if any cellulose family, PVP/ alpha-olefines polymerize resinaes and the macromolecule epithelium shapes such as object, acrylate copolymer, silicone resin, fluorine richness silicone resin At agent.

In order to these ultraviolet lights block cosmetics it is formulation used in conventional raw material, can enumerate, grease, wax, hydrocarbon, The oiliness raw material such as higher fatty acids, higher alcohol, ester oil, silicone oil；Anion, cation, both sexes, nonionic surfactant, UV blockers, tackifier, the high-molecular compound used as peel-forming agent, ultraviolet radiation absorption and blocking agent, antioxygen Agent, metal ion block agent, the toner comprising dyestuff or pigment, fragrance, preservative etc..

In addition, the effective component as practical ultraviolet blocking-up further includes cinnamic acid, glycerol other than above-mentioned ingredient P aminobenzoates, drometrizole (Drometrizole), galloyl gallate trioleate, 3- (4- methyl benzyl Alkene)-camphor, Anthranilate, Benzophenone -3, Benzophenone -4, Benzophenone -8, Uvinul BMBM, methoxy Osmanthus ethyl ester, adenosine, octocrylene (Octocrylene), octyldimethyl p-aminobenzoic acid, methoxyl group Cinnamic acid monooctyl ester, octyl salicylate, octyl triazone, p-aminobenzoic acid, 2- benzimidazole -5- sulfonic acid, salicylic acid front three ring Own ester, zinc oxide, titanium dioxide, isopentyl-p- Methoxycinnamate, bis-ethylhexoxyphenol methoxyphenyl triazine (BisEthylhexyloxyphenol Methoxyphenyl Triazine), two benzimidazole sulphonic acid ester sodium salt of phenylene, (benzal malonic acid salt is poly- for amodi- Ethylhexysalicylate, Diethylhexyl Butamido Triazon, Dimethicodiethylbenzalmalonate Siloxanes) (Polysilicone-15 (Dimethicodiethylbenzal Malonate)), di-2-ethylhexylphosphine oxide benzotriazole four Methyl butyl phenol, Terephthalidene Dicamphor Sulfonic Acid and its esters etc..

But these ultraviolet lights are provided in only after processing to next time when blocking ingredient on skin, hair or fiber Short time effect before washing needs to handle again, cause comparatively laborious after cleaning.

Generally, wound is the state that due to applied force and the continuity of the normal configuration of bodily tissue is destroyed, according to not Same reason can be divided into, and what as external force, the capillary of subcutaneous tissue was injured wounds, abrades caused by sharp keen external force, quilt Skin lacerations caused by the stabbing of the pollutions such as ice quarrel, nail, branch, knife, cullet and cut wound, blunt heavy external force caused by performing the operation Contusion, skin be tightened up or stretch caused by lacerated wound etc..

In order to increase the therapeutic effect of wound, used method is initial stage dry treatment method, covers wound, remains dry It is dry, thus the method for curing wound, as eliminating known the shortcomings that being dried agent, the anchorage i.e. between wound face Method without making epithelium damage has non-woven fabrics gauze, unfixed property gauze, unfixed property absorption pad etc..It is treated as wetting Method, as medicine is created etc. the treatment of chronic refractories skin ulcer with significant efforts with the therapeutic agent for representing meaning, Film, filled-type pearl, hydrocolloid, alginate esters, foamed glue, hydrogel etc. can be enumerated.Recently, widely used drug delivery The method that system is difficult to the chronic trauma cured as effective treatment, growth factor adjust wound-healing process, can effectively into The treatment of row wound, wherein representative raw body engages ingredient, includes growth factor, physiological activator, necrotic tissue Remover, antibacterial liniment etc..

As described above, the purpose of the raw body bonding composition for treating the skin lesion sites such as wound is, faster more Effective treatment wound site, as far as possible preventing from scar beautify the skin at scar position such as original skin, to increase evil spirit Power.

In addition, raw body bonding composition can be used for engaging the purposes of the hair of bifurcated.

The raw body bonding composition that skin or hair can be engaged, generally comprises: for the washing one's face of nursing skin, whole Reason, the basis composition with the engagement function between skin or hair, alternatively, foundation cream, part (Point) have with product etc. There is the composition of the engagement function of skin or hair.The combination with the engagement function between skin or hair for scalp Object, including, it cleans, conserve first, net hair, hair care, educating the engagement having between skin or hair for scalp such as hair maintenance The composition of function.

It include: oil to constitute conventional raw material used in this composition with the engagement function between skin or hair The oiliness raw material such as rouge, wax, hydrocarbon, higher fatty acids, higher alcohol, ester oil, silicone oil, anion, cation, amphoteric ion, nonionic Type surfactant, moisturizer, tackifier and the high-molecular compound used as peel-forming agent, ultraviolet radiation absorption and resistance Disconnected agent, antioxidant, metal ion block agent, the toner containing dyestuff and pigment, fragrance, preservative etc..

However, only raw body bonding composition raw material pieceable between these skins or hair and medicine component are used It in the case where skin or hair, is arrived during cleaning after treatment, of short duration effect is provided, need to locate again after cleaning Reason, causes comparatively laborious, and duration effect is restricted.

Patent document 1 discloses a kind of skin or Hair grooming non-water system personal care product, has at non-water system end and is selected from The nursing compositions of one or more of following functional group, the functional group can be with the residue of protein shapes of hair or skin surface At covalent bond, the functional group is carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanates, sulphur cyanogen Acid esters goes back oxygen compound, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, sulphur Alcohol, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, disulphide, (R is selected from being made of alkyl, aryl, aralkyl, cyclic hydrocarbon radical and unsaturated ring alkyl for ketone and the functional group indicated by RX Group in any one, X I, Br or Cl), and be divided into non-water system end and water system end, make after being mixed shortly before the use With, using a variety of functional groups as proposed above, it is harmful to the human body, alternatively, constitute in the amino acid of the protein of hair or skin, Its content target is hair (1.9~3.1%), a small amount of lysine of cornu cutaneum matter (3.1~6.9%) left and right, alternatively, target For hair (16.6~18%), the cysteine of cornu cutaneum matter (2.3~3.8%) left and right, therefore there are reaction efficiency reduction, it needs The problem of each substance is synthesized respectively.

Background technology document

Patent document 1: Korean Patent Laid-Open the 2008-0064467th

Summary of the invention

The purpose of the present invention is to provide a kind of coloring compositions can without damage hair, skin, fiber or leather With lasting imparting semipermanent dyeing effect.

It is further an object that a kind of humidity-preserving type cosmetic composition is provided, it, can without damage hair or skin With lasting imparting semipermanent moistening effect.

It is further an object that a kind of nursing type cosmetic composition is provided, it, can without damage hair or skin With lasting imparting semipermanent nursing efficacy.

It is further an object that a kind of ultraviolet blocking-up composition is provided, without damage hair, skin or fibre Dimension can continue to assign semipermanent ultraviolet light barrier effect.

It is further an object that a kind of raw body engagement composition is provided, without damage hair or skin, Ke Yichi It is continuous to assign semipermanent raw body splicing results.

In order to solve the above problems, the present invention provides a kind of coloring composition, containing carbodiimide compound with And dyestuff.

In order to solve above-mentioned another project, the present invention provides a kind of moisture-keeping cosmetic composition, contains carbodiimide Class compound and moisturizing ingredient.

In order to solve above-mentioned another project, the present invention provides a kind of nursing cosmetic composition, contains carbodiimide class Compound and nursing compositions.

In order to solve above-mentioned another project, the present invention provides a kind of ultraviolet light blocking composition, contains carbodiimide Class compound and ultraviolet light block ingredient.

In order to solve above-mentioned another project, the present invention provides a kind of raw body bonding composition, contains carbodiimide class Compound and raw body engage ingredient.

Invention effect

Coloring composition according to the present invention, comprising that can be total to the residue of protein of hair, skin, fiber or leather The imported chemically-reactive dyes of the particular functional group of valence link and/or carbodiimide compound, in no damage hair, skin In the case where skin, fiber or leather, covalent bond is formed, to provide semipermanent required color.

Moisture-keeping cosmetic composition according to the present invention, comprising can be with the residue of protein covalent bond of hair or skin The imported reactive moisturizing ingredient of particular functional group and/or carbodiimide compound, do not damage hair or skin In the case where, covalent bond is formed, to provide semipermanent moistening effect.

Nursing according to the present invention applies some make up composition, comprising can be with the residue of protein covalent bond of hair or skin The imported reactive nursing compositions of particular functional group and/or carbodiimide compound, do not damage hair or skin In the case where, covalent bond is formed, to provide semipermanent nursing efficacy.

Ultraviolet light according to the present invention blocking applies some make up composition, comprising can be with the albumen of hair, skin or fiber The imported reactive ultraviolet light of the particular functional group of matter residue covalent key blocks ingredient and/or carbodiimide compound, In the case where not damaging hair, skin or fiber, covalent bond is formed, to provide semipermanent ultraviolet light barrier effect.

Raw body according to the present invention engages the composition that applies some make up, comprising that can be total to the residue of protein of hair or skin The imported reactive raw body engagement ingredient of the particular functional group of valence link and/or carbodiimide compound, do not damage head In the case where hair or skin, covalent bond is formed, to provide semipermanent raw body splicing results.

Detailed description of the invention

Fig. 1 shows the colored state of the consumption ox hair of the comparative example 1 after having one's hair wash 10 times and embodiment 1.

Fig. 2 shows the colored states of the wool fiber of the embodiment 4 and 5 after hair washing 1 time, hair washing 10 times.

Fig. 3 is to show the hair state handled before and after hair using the raw body bonding composition of the embodiment of the present invention 42 Photo.

Specific embodiment

The present invention relates to a kind of coloring compositions, contain carbodiimide compound and dyestuff.

Coloring composition according to the present invention passes through knot for example, reacting carbodiimide compound with known dye Closed the chemically-reactive dyes of carbodiimide, formed and hair, skin, fiber or leather protein between covalent bond, from And reach the maximization of dye activity.

The usage amount of above-mentioned carbodiimide compound is 0.001 to 10 relative to all compositions of 100 parts by weight Parts by weight, 0.01 to 7 parts by weight or 0.1 to 5 parts by weight.In the case that its content is less than 0.001 parts by weight, exists and be difficult to The problem of reaching lasting dyeing effect has been more than reflecting point present in skin in the case where more than 10 parts by weight, and mistake It spends existing carbodiimide compound to be reacted in the state of not with dermoreaction with active principle, to fail to help Duration is improved, there are problems that can only be as loss ingredient.

Dyestuff as used in the present invention can be containing selected from NO as chromophore₂, N=N, C=O, C=C, C One or more of the group of=N, C=S, N=O and N=NO composition atomic radical, but not limited to this.In addition, above-mentioned dyestuff In, it, can be containing selected from-OCH as toning group₃、-N(CH₃)₂、 -NH(CH₃)、-NO₂、-CF₃、-OH、-OCH₃,-CL, with And-NH₂One or more of group of composition atomic radical, but not limited to this.In addition, above-mentioned dyestuff can containing selected from- COONa、-COOK、 -COOH、-NH₂、-NHR、NR₂,-CL ,-Br ,-I and-F composition one or more of group reactive group Group, but not limited to this.In addition, above-mentioned dyestuff can be the natural dye used in hair, skin, fiber, leather etc. or conjunction At dyestuff, above-mentioned natural dye can be alizarinopurpurin (purpurin), purple alizarin pigment (Munjistin), melanin (Melanin) or the presoma of melanin, but it is not limited to this, above-mentioned synthetic dyestuffs, can be redness of the skin or complexion 3, redness of the skin or complexion 104, Redness of the skin or complexion 105, redness of the skin or complexion 201, redness of the skin or complexion 202, redness of the skin or complexion 220, redness of the skin or complexion 230, redness of the skin or complexion 231, redness of the skin or complexion 232, redness of the skin or complexion No. 401, it is redness of the skin or complexion 405, yellow 4, yellow 202, No. 207 orange, redness of the skin or complexion 106, redness of the skin or complexion 213, redness of the skin or complexion 214, red Color 215, yellow 404, yellow 405, cyan 403, disperse blue 1, disperse violet 1, disperse orange 3, dispersion be black 9, HC indigo plant 2, HC is red 3, HC Huang 5 or HC red 1, and but it is not limited to this.

The usage amount of above-mentioned dyestuff is 0.001 to 50 parts by weight, 0.001 relative to all compositions of 100 parts by weight To 30 parts by weight or 0.01 to 10 parts by weight or 0.1 to 5 parts by weight.In the case that its content is less than 0.001 parts by weight, There are problems that effectively playing its performance when content is more than 50 parts by weight, then there is formulation and dosage form stability and ask Topic.

In particular, dyestuff of the invention contains carboxyl or amido in the molecule, can be improved and carbodiimide compound Between reaction efficiency.

It can be with the residue of protein shape of hair, skin, fiber or leather surface in addition, containing in pigment of the invention At the functional group of covalent bond.

The functional group that covalent bond can be formed with above-mentioned protein is selected from, carbodiimide, imines ester, aromatic yl azide (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo- Hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), azide, carbonic acid Ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, rhodanate, epoxy compound Object, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl Ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, Ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies and ketone composition one of group with On, but not limited to this.

In addition, above-mentioned protein may include the reactive residue of mercapto, hydroxyl, carboxyl or amino.

Above-mentioned carbodiimide compound is the total of the compound of the structure indicated in the molecule containing following chemical formula 1 Claim.

Chemical formula 1

- N=C=N-

Above-mentioned carbodiimide compound preferably comprises the structure of 1 to 1000 or so chemical formula 1, more preferably in molecule The structure of the interior chemical formula 1 containing 1 to 100 or so, more preferably in the molecule containing the knot of 1 to 10 or so chemical formula 1 Structure.

In this case, when the structure of the carbodiimide indicated when intramolecular chemical formula 1 is more than 1000, raw material glues Degree is too big, and molecular weight is excessive, and the reflecting point that can be reacted is excessive, and the molecule containing carbodiimide is very big, and having blocked has The part of functional effect is presented in the molecule of actual functional capability, thus the problem of luminous efficiency reduces.

In the present invention, the concrete example of carbodiimide compound can be enumerated, by the change represented by following chemical formula 2 Object is closed, in following chemical formula 2, the compound that n 4, m are 11 is named as 1,3- bis- (1- isocyanate group -1- Methylethyls) Phenyl-homopolymer, the mono- Methylethyl copolymer of polyethylene glycol (Benzene, 1,3-bis (1-isocyanato-1- Methylethyl)-, homopolymer, polyethylene glycol mono-Me-ether-blocked) (hereinafter, changing The Form of Polymer carbodiimide compound of formula 2).

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

In the present invention, as other examples of carbodiimide compound, the change of the expression of following chemical formula 3 can be used Close object, 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide or 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide Hydrochloric acid.

Chemical formula 3

One preference of coloring composition according to the present invention, the dyestuff with carboxyl, which is prepared into, directly has raw body Active reactivity esters dyestuff form, either, by hair (17.5~21.9%), cornu cutaneum matter (15.5~23.5%) or Amino acid (such as aspartic acid, glutamic acid) the reactivity esterification being present in excess in fiber (19~23%), using containing ammonia The dyestuff of base is capable of the carbodiimide compound of target, thus be prepared into reactive ester form (chemically-reactive dyes), To intensified response efficiency, and then enhance its effect.In addition it is possible to use intramolecular has the carbon for capableing of target other amino acid Diimine, imines ester, virtueization base, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater, The dyestuff of the functional groups such as alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), azide, to increase its effect.

Concrete example more preferably, on the protein surface of dye molecule or skin or hair with carboxyl, Firstly, using the carbodiimide compound of the Form of Polymer such as chemical formula 2 or such as 1- ethyl -3- (3- dimethylamino third Base) carbodiimide compound as carbodiimide hydrochloride carries out primary first-order equation generation of reactive ester, in the reactivity of generation Have again with intramolecular on ester functional groups amino dyestuff or hair, skin, fiber or leather surface amino carry out it is anti- Answer, as a result, to human temperature and and it is affine under conditions of obtain outstanding dyeing effect.Above-mentioned reaction is preferably in pH2~10 Under the conditions of carry out, more preferably carried out under conditions of pH3~9, most preferably the acid condition or slightly acidic water solution in pH4~5 Middle reaction can increase reaction efficiency.The reaction is completed in 1 to 30 minute.

In following reaction equations 1, it is shown that the dye molecule with carboxyl carries out primary anti-with carbodiimide compound It answers, forms reactive ester, and then react with the amino acid of the raw body with amino residue, form the reaction pattern figure of covalent bond.

Reaction equation 1

In following reaction equations 2, the asparagus fern ammonia of the raw body amino acid of the carboxyl as the protein surface with hair is shown Primary first-order equation occurs for acid and glutamic acid and carbodiimide compound, forms reactive ester, so with amino residue Dyestuff reaction, forms the reaction pattern figure of covalent bond.

Reaction equation 2

By carbodiimide compound, the protein of hair and the reaction efficiency of dyestuff are increased, is incorporated on hair Chemically-reactive dyes almost can will not for good and all remain attached because being washed off in the conventional wash of shampoo, detergent, soap etc. The state on hair.

Above-mentioned reaction equation is typical example relevant to hair, skin, fiber, the leather etc. being equally applicable to except hair On.

Dyestuff of the invention can also include to be combined with to form covalent bond with protein and be made of following functional group Group in the chemically-reactive dyes of more than one functional groups that selects, the functional group includes: that carbodiimide, imines ester, aryl are folded Nitride (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), Azide Object, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, rhodanate, ring Oxygen compound, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl Ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, Ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies and ketone.

For example, may include the combination for making carbodiimide compound carry out primary first-order equation generation such as above-mentioned reaction equation 1 There is the dyestuff (chemically-reactive dyes) of carbodiimide.

It is also possible to include the coloring composition with chemically-reactive dyes.

Coloring composition according to the present invention can be with the fatty acid, rouge such as palmitinic acid, stearic acid in order to increase effect Fat alcohol, the cationic surfactants such as long chain alkyl ammonium salt of linear chain or branched chain, cationized cellulose, cationization Guar Cation type polymers, the silicon such as glue, cationized polyvinyl yl pyridines alkanone are used in mixed way, to make formulation be easy.In addition, being Type processed, can add solvent, surfactant, tackifier, stabilizer, preservative, colorant, pH regulator, metal from The formulation ingredients such as son block agent, colorant, swelling agent, appearance investigation agent, pigment, seperated particle.For it is formulation at Point, relative to 100 parts by weight of all compositions, 40 to 99 parts by weight can be used.

Coloring composition according to the present invention, comprising the dye component with functional group, can be used for all hairs with And in the formula of skin coloring agents composition.As the example of coloring composition, (pre-shampoo) group before can be used for having one's hair wash Close object, shampoo, hair care maintenance element, pomade, spraying (spray), mousse (mousse), hair nursing water (hair Lotion), the hairs such as essence, hair cream, permanent hair dye, interim hair dye, agent for permanent hair waving, non-woven fabrics, sheet material or human body can All cosmetic formulations used also may include all formulations for skin.It, can be in the case where fibre The preparations such as including coloring agent.

It is further preferred that having anti-while coloring composition according to the present invention includes carbodiimide compound The dyestuff of answering property functional group, in the case that activity of the above-mentioned preparation in water system reduces, it is easier to be tieed up in non-water system dosage form Its activity is held, in order to adjust pH, is mixed with buffer, in washing process, the method contacted with water is brought it about using preceding Reaction.It can be liquid, piece type, powder powder as the preparation of conventional non-water system cosmetics as the example of non-water system dosage form Type, pastille type, oil, wax, injection (ampoule), gel etc..In addition, carbodiimide compound and dyestuff can be formed with preparation The single formulation of capsule form or two dosage forms separated respectively.Further, it is also possible to it is encapsulated using passing through, will have reactive The method that the derivative and moisture of the form of functional group and the ingredient combination with dyestuff function block.

It is pungent to can be used two in order to increase the dyestuff with functional group for coloring composition according to the present invention The 2- hydrochloric acid ester oils such as base succinate, d-octyl adipate, diethyl sebacate and polyol, polyethylene glycol, propylene glycol, oneself Glycol, butanediol and their metamer, glycerine, benzyl alcohol, ethoxydiglycol and derivative.It is above-mentioned to refer to Solvent can increase the impregnability of hair, skin, fiber or leather, and the solvent as slightly solubility substance uses.In order to increase tool There is the activity of the dyestuff of functional group to maintain effect, it is preferable to use diethyl sebacate, ethoxydiglycol, double-ethyoxyl Ethylene glycol hexamethylene, 1,4- dicarboxylic ester etc..

The present invention relates to a kind of moisture-keeping cosmetic compositions, contain carbodiimide compound and moisturizing ingredient.

Moisture-keeping cosmetic composition according to the present invention, for example, making carbodiimide compound and known moisturizing ingredient Reaction, by combining the moisturizing ingredient of carbodiimide, form it into and hair, skin protein between covalent bond, To reach the maximization of moistening effect.

The usage amount of above-mentioned carbodiimide compound is relative to whole cosmetic compositions of 100 parts by weight 0.001 to 10 parts by weight, 0.01 to 7 parts by weight or 0.1 to 5 parts by weight.In the case that its content is less than 0.001 parts by weight, It is difficult to reach lasting moistening effect, in the case where more than 10 parts by weight, more degree ground have been more than reflecting point present in skin And existing carbodiimide compound reacts in the state of not with dermoreaction with active principle, thus in the presence of failing to improve Duration can only be used as the problem of losing ingredient.

In the present invention, " moistening effect " refers to the normal moisture content of the skin or hair etc. that maintain people, is allowed to soft, has life Gas prevents the damage of bifurcated, coarse etc..

Moisturizing ingredient as used in the present invention may include the natural goods origin from animal, plant, mineral etc. The moisturizing that extract, amino acid, peptide, protein, carbohydrate, vitamin etc. can fill the damaged part of skin or hair is made With ingredient, but not limited to this.For example, it may be selected from one or more of the group that consists of the following compositions, it may be assumed that glycerol, the third two Alcohol, butanediol, dipropylene glycol, pungent ethylene glycol, diglycerol, methyl gluceth, ethoxy ethyl glycol, glyceryl alcohol, propylene glycol, Diethoxy diethylene glycol 2-pyrrolidone-5-carboxylic acid, sodium lactate, pyrrolidone sodium carboxylate (PCA-Na), mineral oil, vaseline, sheep Hair rouge, lotus fragrant plant oil, olive oil, glycosphingolipid, phosphatide, lipid mixture, isononyl isononanoate, glycine betaine, carboxymethyl chitosan, mind It is saturating through amide, glucose ceramide, glycosaminoglycans (Glycosaminoglycans), alpha-glucans, hyaluronic acid, hydrolysis Bright matter acid, glycine betaine, chitosan (chitosan), chitosan succinamide (Chitosan Succinamide), Vitamin E (Tocopherol), urea (Urea), hydroxy ethyl urea, glucose glycoside, γ-PGA, xylitol glucose Glycosides, xylitol, pentaerythritol tetraoctyl stearate, sodium chondroitin sulfate, chondroitin-4-suleate, lack atelocollagen, β-glucan, PEG, three-hexyldecanoic acid of pyridoxine ester, 2-pyrrolidone-5-carboxylic acid's potassium (PCA-K), Polyurethane-epoxy resin sodium, polyglutamic acid, polypropylene Acid glyceride, pine tree polysaccharide (glactoarabinan), -3 cross-linked copolymer of polyglycereol, Sodium Hyaluronate, double-PEG-18 methyl Ether dimethylsilane, double-ethoxydiglycol succinate, lecithin, Ascorbyl Tetraisopalmitate (Ascorbyl Tetraisopalmitate), glycosyl trehalose, hydrogenated starch hydrolysate (Hydrogenated Starch Hydrolysate), 1,2- hexylene glycol, mannitol, arginine, serine, sucrose, PCA, citrulling, glycogen, histidine hydrochloric acid Salt, alanine, threonine, glutamic acid, lysine hydrochloride, phosphate buffer normal saline, creatine, cholesterol isostearate, Cholesterine chloride, cholesteryl nonanoate, BHT, two (lauramide glutamine) Sodium lysinates, maltodextrin, polyquaternium- 39, Vitamin D3 PEG-12 ester, carbohydrate isomer, D-sorbite and their derivative.

The usage amount of above-mentioned moisturizing ingredient, relative to all compositions of 100 parts by weight, be 0.001 to 50 parts by weight, 0.001 to 30 parts by weight or 0.01 to 10 parts by weight or 0.1 to 5 parts by weight.When feelings of its content less than 0.001 parts by weight Under condition, its performance can not be effectively played, when content is more than 50 parts by weight, there are problems that type and dosage form stability processed.

In particular, moisturizing ingredient of the invention contains carboxyl or amino in the molecule, can be improved and carbodiimide class Close the reaction efficiency of object.

In addition, can contain in moisturizing ingredient of the invention can form with the residue of protein of hair or skin surface The functional group of covalent bond.

The functional group that covalent bond can be formed with above-mentioned protein is selected from, by carbodiimide, imines ester, aromatic yl azide (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo- Hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), azide, carbonic acid Ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, rhodanate, epoxy compound Object, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl Ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, One of group composed by ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies and ketone More than, but not limited to this.

In addition, above-mentioned protein may include the reactive residue of mercapto, hydroxyl, carboxyl or amino.

Above-mentioned carbodiimide compound is the total of the compound of the structure indicated in the molecule containing following chemical formula 1 Claim.

Chemical formula 1

- N=C=N-

Above-mentioned carbodiimide compound preferably comprises the structure of at least 1 to 1000 or so chemical formula 1, more preferably In the molecule containing the structure of 1 to 100 or so chemical formula 1, more preferably intramolecular contains 1 to 10 or so chemical formula 1 structure.

In this case, when the carbodiimide that intramolecular chemical formula 1 indicates is more than 1000, the viscosity of raw material is too Greatly, molecular weight is excessive, and the reflecting point that can be reacted is excessive, and the molecule containing carbodiimide is very big, and having blocked has reality The part of functional effect is presented in the molecule of function, thus the problem of luminous efficiency reduces.

In the present invention, it as the concrete example of carbodiimide compound, can enumerate, represented by following chemical formula 2 Compound, in following chemical formula 2, n 4, m be 11 compound be named as the bis- (1- isocyanate group -1- methyl of 1,3- Ethyl)-phenyl homopolymer, the mono- Methylethyl copolymer of polyethylene glycol is (hereinafter, the Form of Polymer carbodiimide class of chemical formula 2 Compound).

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

In the present invention, as other examples of carbodiimide compound, the change of the expression of following chemical formula 3 can be used Close object, 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide or 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide Hydrochloric acid (1-ethyl-3- (3-dimethylaminopropyl) carbodiimideHCl).

Chemical formula 3

Preference according to the present invention as moisture-keeping cosmetic composition, the moisturizing ingredient with carboxyl is prepared into Directly there is the reactive reactive esters moisturizing ingredient form of raw body, or by hair (17.5~21.9%), cornu cutaneum matter Amino acid (such as aspartic acid, glutamic acid) the reactivity esterification being present in excess in (15.5~23.5%), using containing amino Moisturizing ingredient is capable of the carbodiimide compound of target, be prepared into reactivity ester form (reactive moisturizing at Point), thus intensified response efficiency, and then enhance its effect.In addition it is possible to use intramolecular have as carbodiimide, imines ester, Aromatic yl azide (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimidyl acyl are sub- Amine ester (sulfo-hydroxy succinimide ester), hydrazides, halogenation acetyl (Haloacetyl), is folded alkoxyamine It can be with the moisturizing ingredient of the functional group of target amino acid, to increase its effect as nitride etc..

Concrete example more preferably, in the protein surface of moisturizing ingredient molecule, skin or hair with carboxyl On, first using the carbodiimide compound of the Form of Polymer such as chemical formula 2 or such as 1- ethyl -3- (3- dimethylamino third Base) carbodiimide compound as carbodiimide hydrochloride carries out primary first-order equation generation of reactive ester, in the reactivity of generation Make again on ester functional groups intramolecular have amino moisturizing ingredient react, or with the amino of hair or skin surface into Row reaction, to obtain outstanding moistening effect.Above-mentioned reaction preferably carries out under conditions of pH2~10, more preferably in pH3~9 Under conditions of carry out, most preferably reacted in the acid condition or slightly acidic water solution of pH4~5, reaction efficiency can be increased.It should Reaction is completed in 1 to 30 minute.

It is primary to show that moisturizing ingredient molecule and carbodiimide compound with carboxyl carry out in following reaction equations 3 Reaction forms reactive ester, and then is reacted with the amino acid of the raw body with amino residue, forms the reaction mould of covalent bond Formula figure.

Reaction equation 3

It is shown in following reaction equations 4, in the day of the raw body amino acid with carboxyl of the protein surface of hair or skin Primary first-order equation occurs for aspartic acid and glutamic acid and carbodiimide compound, forms reactive ester, so with it is residual with amino The moisturizing ingredient of base reacts, and forms the reaction pattern figure of covalent bond.

Reaction equation 4

By carbodiimide compound, the reaction efficiency of the protein and moisturizing ingredient of hair or skin increases, in conjunction with Reactive moisturizing ingredient on hair or skin will not be washed off because of the conventional wash of shampoo, soap etc., can almost be tieed up Hold the state for being permanently affixed to hair or skin.

Moisturizing ingredient of the invention can also include to be combined with that covalent bond can be formed with protein and by following functional group The reactive moisturizing ingredient of more than one functional groups selected in the group of composition, the functional group include: carbodiimide, imines Ester, aromatic yl azide (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimidyl acyl Imines ester (sulfo-hydroxy succinimide ester), hydrazides, halogenation acetyl (Haloacetyl), is folded alkoxyamine Nitride, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, thiocyanic acid Salt, epoxide, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, sulphur Alcohol, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies, And ketone.

For example, may include such as above-mentioned reaction equation 1, make the generation of carbodiimide compound primary first-order equation is combined with carbon The moisturizing ingredient of di-imidogen.It is also possible to include the moisture-keeping cosmetic with above-mentioned reactive moisturizing ingredient Composition.

Moisture-keeping cosmetic composition according to the present invention can be fatty with palmitinic acid, stearic acid etc. in order to increase effect Acid, fatty alcohol, linear chain or branched chain cationic surfactants, cationized cellulose, the cation such as long chain alkyl ammonium salt Change cation type polymers, the silicon such as guar gum, cationized polyvinyl yl pyridines alkanone to be used in mixed way, to make formulation be easy. In addition, solvent, surfactant, tackifier, stabilizer, preservative, coloring can be added for the type processed of cosmetic formulations Agent, pH regulator, metal ion block agent, colorant, swelling agent, appearance investigation agent, pigment, seperated particle etc. are used for cosmetics Formulation ingredient.40 to 99 weight can be used relative to 100 parts by weight of all compositions for formulation ingredient Part.

Moisture-keeping cosmetic composition according to the present invention includes the moisture-keeping functions ingredient with functional group, for Hydra The formula of cosmetic composition.As the Application Example of skin products, the basic cosmetics (makeup of protection skin is generally included Water, essence, essence, lotion, face cream etc.), makeup cosmetic (sun screen, foundation cream, powder, eye shadow, lip gloss, lipstick, lip gloss Deng), nail beautifier (have a manicure, nutritional agents, hardening agent, finishing coat etc.), cleaning applies some make up (facial cleanser, makeup remover, makeup removing Liquid, makeup removing frost, makeup removing gel, facial mask, mask, perfumed soap, towel of washing one's face etc.), sunscreen cosmetic, moisturizing cosmetics (skin lotion, shower Dew, skin cream, soothing oil etc.), for hair, may include shampoo, conditioning liquid, hair conditioner, hair film, daily hair treatment, wax, The all formulations such as gel, spraying.

It is further preferred that while moisture-keeping cosmetic composition according to the present invention includes carbodiimide compound, Comprising the moisturizing ingredient with reactive functional groups, in the case that activity of the above-mentioned preparation in water system reduces, it is easier to Maintain its activity in non-water system dosage form, in order to adjust pH, mixed with buffer using preceding, by washing process with water The method of contact brings it about reaction.As the example of non-water system dosage form, the preparation as conventional non-water system cosmetics can be, It can be liquid, piece type, powder powder type, pastille type, oil, wax, injection (ampoule), gel etc..In addition, carbodiimide class Compound and moisturizing ingredient, can be with preparation at the single formulation or two dosage forms that separate respectively of capsule shape state.Further, it is also possible to sharp With by forming capsule, the derivative and water of the form that the ingredient with reactive functional group and with moisture-keeping functions is combined Divide the method blocked.

Moisture-keeping cosmetic composition according to the present invention can make to increase the moisturizing with functional group With the 2- hydrochloric acid ester oils such as dioctyl succinate acid esters, d-octyl adipate, diethyl sebacate and polyol, polyethylene glycol, third Glycol, hexylene glycol, butanediol and their metamer, glycerine, benzyl alcohol, ethoxydiglycol and derivative.It is above-mentioned The solvent referred to can be used in the impregnability for increasing hair, skin, fiber or leather, the solvent as slightly solubility substance.For The activity for increasing the moisturizing ingredient with functional group maintains effect, it is preferable to use diethyl sebacate, ethyoxyl diethyl two Alcohol, double-ethoxy ethyl glycol hexamethylene, 1,4- dicarboxylic ester etc..

The present invention relates to a kind of nursing cosmetic compositions, contain carbodiimide compound and nursing compositions.

Nursing cosmetic composition according to the present invention, for example, keeping carbodiimide compound and known nursing compositions anti- It answers, by combining the reactive nursing compositions of carbodiimide, covalent bond is formed with the protein of hair or skin, to reach To the maximization of nursing efficacy.

The usage amount of above-mentioned carbodiimide compound is 0.001 to 10 relative to all compositions of 100 parts by weight Parts by weight, 0.01 to 7 parts by weight or 0.1 to 5 parts by weight.It is existing to be difficult in the case that its content is less than 0.001 parts by weight The problem of reaching lasting nursing efficacy has been more than reflecting point present in skin and mistake in the case where more than 10 parts by weight It spends existing carbodiimide compound to react in the state of not with dermoreaction with active principle, thus in the presence of failing to improve Duration, and the problem of losing ingredient can only be used as.

In the present invention, nursing is to show skin or hair assigns the excellent spies such as smooth, soft, soft, moist, swelling sense Property, thus beautifying skin or hair, enhancing glamour, change appearance, alternatively, hair and skin in order to maintain health, to apply It smears, dissipate and smear for the purpose of body and similar method use.Consider from nursing efficacy, can present assign gloss and It is moist, reduce electrostatic and other effects.

Nursing compositions as used in the present invention may include that the natural goods origin from animal, plant, mineral etc. mentions Take object, amino acid, carboxylic propylhomoserin, protein etc. that can fill the nursing role ingredient of damaged part of skin or hair, but unlimited In this.For example, can select free polymer class, silicon class, fatty alcohols, fatty acid, paraffin class, ester oil class and they spread out More than one in the group of biotic component.

Above-mentioned natural goods origin extract includes marine algae extract, sunflower oil extract, shrubby sophora extract, ginseng extraction Object, coptis extract, calendula extract, silver birch juice, silver birch extract, pepper extract, day sieve extract, fingered citron Mandarin orange extract, Japan cypress extract, Actions of Extracts of Rhodiola Sachalinensis, atractylodes chinensis, collapse jorum extract, red ginseng water, fritillaria are extracted Object, lily of the valley extract, honeycomb extract, currant extract, Punica granatum L. extract, lemon extract, extract from pine needles, green tea mention Take object, Caulis et Folium Brassicae capitatae, Mel extract, blueberry extract, fruit extracts, lavender extract, hyacinth bean extract (lentil bean), ginger water extract etc., as above-mentioned protein and peptide, may include giant silkworm silk, silk, Poly-D-lysine, seaweed, wool and hair, the protein obtained by wheat and peptide etc..

As above-mentioned amino acid include glycine, alanine, valine, leucine, isoleucine, threonine, serine, Cysteine, cystine, methionine, aspartic acid, asparagine, glutamic acid, diiodotyrosine, lysine, arginine, group ammonia Acid, phenylalanine, tyrosine, tryptophan, proline, hydroxy-proline etc..

In addition, above-mentioned polymerization species can be used molecular weight 1000 to 1,000,000 or so straight chain (linier) and branch, The polymer of the various replacements containing double bond or cyclic structure between carbon carbon also can be used as needed in network polymers, Wherein, it is preferable to use any end of molecular end includes at least more than one such as-COONa ,-COOK ,-COOH ,-NH₂、- NHR、-NR₂,-Cl ,-Br, for adhere to raw body reactive group there is reactive residue as-I or-F etc., to make The reaction of raw body reactive functional groups attachment is easy to carry out.More preferably using carbon atom number be 10000 or even 500,000 or so it is straight Chain (linier) and branched polymer, and in the molecule any end of end include at least more than one as-COONa ,- COOK、-COOH、-NH₂、-NHR、-NR₂,-Cl ,-Br, for adhere to raw body reactive group there is reactivity as-I or-F etc. Residue, so as to make raw body reactive functional groups adhere to reaction be easy carry out.For example, polyamines polymer, polycarboxylic acid polymer, Methacryloyl ethyl betaine/methacrylate copolymer (Methacryloylethyl Betaine/ Methacrylate Copolymer), octylacrylamide/acrylate/Butylaminoethyl methacrylate copolymers The both sexes such as object (Octylacrylamide/Acrylates/Butylaminoethyl Methacrylate Copolymer) are poly- Close object；Or polyvinylpyrrolidone, PVP/VA copolymer, PVP/ dimethyl amino ethyl methacrylate copolymer (PVP/ Dimethylaminoethylmethacrylate Copolymer) etc. non-ionic polyalcohols；Acrylate-methacrylic acid Ester copolymer (Acrylate Methacrylate Copolymer), VA/ crotonates/vinyl neodecanoic acid ester copolymer Anionic polymers such as (VA/Crotonates/Vinyl Neodecanoate Copolymer), but it is not limited to this.

Above-mentioned silicon class, can enumerate, dimethicone, trimethyl silicone oil, phenyl trimethicone silicone oil, amino dimethyl-silicon Oil, aminophenyl trimethyl silicone oil ,-five phenyl trimethyl silicane oil of amino, dimethyl polysiloxane (Dimethylpolysiloxane), methyl phenyl silicone, decamethylcyclopentasiloxane, methyl trimethoxy base silicone oil, phenyl Trimethyl silicone oil, methyl-silicone oil, cyclomethicone, alkyl methyl siloxane, dimethicone copolyol (Dimethicone Copolyol), trimethylsilyl ammonia-terminated polydimethylsiloxane (Trimethylsilylamodimethicone) form Compound, but not limited to this.

Above-mentioned aliphatic alcohols is the aliphatic of straight chain (linier) and branch that carbon atom number is 10 or even 50 or so Alcohol compound, for example, it is preferable to using laruyl alcohol, hexadecanol, octadecanol, isooctadecane alcohol, tadenan etc., but not It is limited to this.

Above-mentioned fatty acid is the aliphatic acid of straight chain (linier) and branch that carbon atom number is 10 or even 50 or so Class compound, for example, it is preferable to using 18- methyl eicosenoic acid, cetyl acid, Eighteen alkyl acid, isooctadecane base acid etc., But not limited to this.

Candelila wax (candelillia wax), Brazil wax, rice bran wax, honey can be used for example in above-mentioned wax class Wax, lanolin, ceresine, hard wax (Ceresine wax), paraffin (paraffin wax), microwax, polyethylene wax etc., but it is unlimited In this.

Above-mentioned ester oil, for example, can be to use the cool isopropyl propionate of Beans, the cool acid butyl ester of Beans, isopropyl palmitate, ethyloctadecanoic acid The cool sour cetyl ester of ester, linoleic acid isopropyl ester, Beans cool the acid last of the ten Heavenly stems Zhi, Beans, cetanol palmitate, the poly- isobutyl ester of hydrogenation (Hydrogenated polyisobutaine) etc., but it is not limited to this.

The usage amount of above-mentioned nursing compositions, relative to all compositions of 100 parts by weight, be 0.001 to 50 parts by weight, 0.001 to 30 parts by weight or 0.01 to 10 parts by weight or 0.1 to 5 parts by weight.When feelings of its content less than 0.001 parts by weight Under condition, the effect provided by effective component is limited, and when content is more than 50 parts by weight, the ageing stability of type and dosage form processed is deposited In problem, there are problems that the ingredient without reaction and as loss.

In particular, nursing compositions of the invention contain carboxyl or amino in the molecule, can be improved and carbodiimide class Close the reaction efficiency of object.

In addition, containing in nursing compositions can form covalently in the present invention with the residue of protein of hair or skin surface The functional group of key.

The functional group that covalent bond can be formed with above-mentioned protein can be in the group being made of following functional group More than one, that is, carbodiimide, imines ester, aromatic yl azide (arylazide), diazomethane, methylol phosphorus, phenyl-pentafluoride Ester, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), alkoxyamine, acyl Hydrazine, halogenation acetyl (Haloacetyl), azide, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, rhodanate, epoxide, toluene fulfonate (Tosylate), succinimide, hydroxyl Succinimide ester (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, Acrylic or methacrylic acid ester, two sulfonated bodies and ketone, but not limited to this.

In addition, above-mentioned protein may include the reactive residue of mercapto, hydroxyl, carboxyl or amino.

Above-mentioned carbodiimide compound is the total of the compound of the structure indicated in the molecule containing following chemical formula 1 Claim.

Chemical formula 1

- N=C=N-

Above-mentioned carbodiimide compound is, preferably the intramolecular structure that contains 1 to 1000 or so chemical formula 1, more Preferably the intramolecular structure that contains 1 to 100 or so chemical formula 1, more preferably intramolecular contain 1 to 10 or so change The structure of formula 1.

In this case, when the structure of intramolecular chemical formula 1 is more than 1000, the viscosity of raw material is too big, molecular weight mistake Greatly, the reflecting point that can be reacted is excessive, and the molecule containing carbodiimide is very big, has blocked in the molecule with actual functional capability The part of functional effect is presented, thus the problem of luminous efficiency reduces.

In the present invention, it as the concrete example of carbodiimide compound, can enumerate, represented by following chemical formula 2 Compound, in following chemical formula 2, n 4, m be 11 compound be named as the bis- (1- isocyanate group -1- methyl of 1,3- Ethyl)-phenyl homopolymer, the mono- Methylethyl copolymer of polyethylene glycol is (hereinafter, the Form of Polymer carbodiimide class of chemical formula 2 Compound).

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

In the present invention, as other examples of carbodiimide compound, the change of the expression of following chemical formula 3 can be used Close object, 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide or 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide Hydrochloric acid.

Chemical formula 3

Nursing compositions with carboxyl are prepared into direct tool by the preference of nursing cosmetic composition according to the present invention There is the reactive reactive esters nursing compositions form of raw body, either, by hair (17.5~21.9%), cornu cutaneum matter (15.5 ~23.5%) amino acid (such as aspartic acid, glutamic acid) the reactivity esterification being present in excess in, uses the nursing containing amino Ingredient is capable of the carbodiimide compound of target, is prepared into reactive ester form (reactive nursing compositions), thus Intensified response efficiency, and then enhance its effect.In addition it is possible to use intramolecular has such as carbodiimide, imines ester, aryl azide Compound (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), Azide It can be with other nursing compositions of the functional group of target amino acid, it is possible thereby to increase its effect as object etc..

Concrete example more preferably, in the protein surface of nursing compositions molecule, skin or hair with carboxyl On, firstly, using the carbodiimide compound of the Form of Polymer of chemical formula 2 or such as 1- ethyl -3- (3- dimethylamino third Base) carbodiimide compound as carbodiimide hydrochloride carries out primary first-order equation generation of reactive ester, in the reactivity of generation The nursing compositions for making intramolecular have amino on ester functional groups again are reacted, or are reacted with the amino of hair or skin surface, Obtain outstanding nursing efficacy.Above-mentioned reaction preferably carries out under conditions of pH2~10, more preferably under conditions of pH3~9 into Row, most preferably reacts in the acid condition or slightly acidic water solution of pH4~5, can increase reaction efficiency.The reaction 1 to It is completed in 30 minutes.

It is indicated in following reaction equations 5, nursing compositions molecule and carbodiimide compound with carboxyl carry out primary Reaction forms reactive ester, and then reacts with the amino acid of the raw body with amino residue, forms the reaction pattern of covalent bond Figure.

Reaction equation 5

It is shown in following reaction equations 6, the raw body amino acid with carboxyl as the protein surface of hair or skin Aspartic acid and glutamic acid and carbodiimide compound carry out primary first-order equation, form reactive ester, so with amino The nursing compositions of residue are reacted, and the reaction pattern figure of covalent bond is formed.

Reaction equation 6

By carbodiimide compound, the reaction efficiency of the protein and nursing compositions of hair or skin increases, in conjunction with Reactive nursing compositions on hair or skin will not be washed off in the conventional wash of shampoo, soap etc., almost can Maintain the state for being permanently attached to hair or skin.

Nursing compositions of the invention, can also comprising be combined with can be formed with protein covalent bond selected from by with I The reactive nursing compositions of the functional group of one or more of group of composition can be rolled into a ball, that is, carbodiimide, imines ester, aryl azide Compound (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), Azide Object, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, rhodanate, ring Oxygen compound, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl Ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, Ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies and ketone.

For example, may include such as above-mentioned reaction equation 1, make the generation of carbodiimide compound primary first-order equation is combined with carbon The nursing compositions of diimine.It is also possible to include the nursing cosmetic combinations with above-mentioned reactive nursing compositions Object.

Nursing cosmetic composition according to the present invention can be fatty with palmitinic acid, stearic acid etc. in order to increase effect Acid, fatty alcohol, linear chain or branched chain cationic surfactants, cationized cellulose, the cation such as long chain alkyl ammonium salt Change cation type polymers, the silicon such as guar gum, cationized polyvinyl yl pyridines alkanone to be used in mixed way, to make formulation be easy. In addition, may include solvent, surfactant, tackifier, stabilizer, preservative, coloring for the type processed of cosmetic formulations Agent, pH regulator, metal ion block agent, colorant, swelling agent, appearance investigation agent, pigment, seperated particle etc. are used for cosmetics Formulation ingredient.40 to 99 weights can be used relative to 100 parts by weight of all compositions for formulation mentioned component Measure part.

Nursing according to the present invention applies some make up composition comprising having the nursing function ingredient of functional group, uses for nursing The formula of cosmetic composition.As the Application Example of skin products, the basic cosmetics (makeup of protection skin is generally included Water, essence, essence, lotion, face cream etc.), makeup cosmetic (sun screen, foundation cream, powder, eye shadow, lip gloss, lipstick, lip gloss Deng), nail beautifier (have a manicure, nutritional agents, hardening agent, finishing coat etc.), cleaning applies some make up (facial cleanser, makeup remover, makeup removing Liquid, makeup removing frost, makeup removing gel, facial mask, mask, perfumed soap, towel of washing one's face etc.), sunscreen cosmetic, moisturizing cosmetics (skin lotion, shower Dew, skin cream, soothing oil etc.), for hair, may include shampoo, conditioning liquid, hair conditioner, hair film, daily hair treatment, wax, The all formulations such as gel, spraying.

It is further preferred that while nursing cosmetic composition according to the present invention includes carbodiimide compound, packet Containing the nursing compositions with reactive functional groups, in the case that activity of the above-mentioned preparation in water system reduces, it is easier to Its activity is maintained in non-water system dosage form, in order to adjust pH, is mixed with buffer, by connecing in washing process with water using preceding The method of touching brings it about reaction.As the example of non-water system dosage form, the preparation as conventional non-water system cosmetics can be, it can be with It is liquid, piece type, powder powder type, pastille type, oil, wax, injection (ampoule), gel etc..In addition, carbodiimide class chemical combination Object and nursing compositions, two dosage forms that can be separated by the single formulation in the form of preparation formation capsule or respectively.Further, it is also possible to utilize By forming capsule, the derivative and moisture of the form that the ingredient with reactive functional group and with nursing function is combined The method of blocking.

Nursing cosmetic composition according to the present invention can be used two to increase the nursing efficacy with functional group The 2- hydrochloric acid ester oils such as octenyl succinate, d-octyl adipate, diethyl sebacate and polyol, polyethylene glycol, propylene glycol, Hexylene glycol, butanediol and their metamer, glycerine, benzyl alcohol, ethoxydiglycol and derivative.It is above-mentioned to refer to Solvent, the impregnability of hair, skin can be increased, the solvent as slightly solubility substance uses.In order to increase with functional group Nursing compositions activity maintain effect, it is preferable to use diethyl sebacate, ethoxydiglycol, double-ethyoxyl second two Alcohol hexamethylene, 1,4- dicarboxylic ester etc..

The present invention relates to a kind of ultraviolet light blocking compositions, block containing carbodiimide compound and ultraviolet light Ingredient.

Ultraviolet light according to the present invention, which blocks, uses composition, for example, hindering carbodiimide compound and known ultraviolet light It is broken into and point is reacted, the ultraviolet light by combining carbodiimide blocks ingredient, forms it into the egg with hair or skin The covalent bond of white matter, to reach the maximization of ultraviolet light barrier effect.

The usage amount of above-mentioned carbodiimide compound is 0.001 to 10 relative to all compositions of 100 parts by weight Parts by weight, 0.01 to 7 parts by weight or 0.1 to 5 parts by weight.In the case that its content is less than 0.001 parts by weight, it is difficult to reach Lasting ultraviolet light barrier effect has been more than reflecting point present in skin and has excessively deposited in the case where more than 10 parts by weight Carbodiimide compound reacted in the state of not with skin or fiber-reactive with active principle, thus in the presence of failing to mention High duration, and the problem of losing ingredient can only be used as.

In the present invention, " ultraviolet light barrier effect " refers to, skin or hair under ultraviolet light are leaked in protection life, with Prevent the function because of UV-induced evils and damage.

It includes: p-aminobenzoic acid derivative (PABA), cinnamic acid that ultraviolet light as used in the present invention, which blocks ingredient, The ultraviolet absorbing agents such as derivative, salicyclic acid derivatives, methanone derivatives；At random dose of the ultraviolet lights such as titanium oxide, zinc oxide；It is fine Tie up resinaes and the macromolecules such as plain class, PVP/ alpha-olefines polymerization object, acrylate copolymer, silicone resin, fluorine richness silicone resin Peel-forming agent.In addition, the effective component as practical ultraviolet blocking-up, such as can be in group composed by following component and select That selects is above, i.e. cinnamic acid, glyceryl p-aminobenzoate, drometrizole (Drometrizole), Gallate Acyl gallate trioleate, 3- (4- methyl benzyl alkene)-camphor, Anthranilate, Benzophenone -3, Benzophenone -4, Benzophenone -8, Uvinul BMBM, cinoxate, adenosine, octocrylene (Octocrylene), octyl Dimethyl-p-aminobenzoate, octyl methoxycinnamate, octyl salicylate, octyl triazone, p-aminobenzoic acid, 2- benzo Imidazoles -5- sulfonic acid, heliophan, zinc oxide, titanium dioxide, isopentyl-p- Methoxycinnamate, double-ethyl Own oxy phenol anisyl triazine (BisEthylhexyloxyphenol Methoxyphenyl Triazine), phenylene two Benzimidazole sulfonic acid ester sodium salt, amodi- Ethylhexysalicylate, Diethylhexyl Butamido Triazon, polysiloxanes- 15 (benzal malonic acid salt polysiloxanes) (Polysilicone-15 (Dimethicodiethylbenzal Malonate)), Methylen Bis-Benzotriazolyl, Terephthalidene Dicamphor Sulfonic Acid and its esters.

Above-mentioned ultraviolet light blocks the usage amount of ingredient, is 0.001 to 50 weight relative to all compositions of 100 parts by weight Measure part, 0.001 to 30 parts by weight or 0.01 to 10 parts by weight or 0.1 to 5 parts by weight.When its content is less than 0.001 weight In the case where part, its performance can not be effectively played, when content is more than 50 parts by weight, type and dosage form stability processed, which exist, is asked Topic.

In particular, ultraviolet light of the invention blocks ingredient to contain carboxyl or amino in the molecule, can be improved sub- with carbon two The reaction efficiency of aminated compounds.

It can be with the egg of hair, skin or fiber surface in addition, can contain in the ingredient of ultraviolet light blocking in the present invention The functional group of white matter residue formation covalent bond.

The functional group that covalent bond can be formed with above-mentioned protein selects one in the group as composed by following functional group Kind or more, the functional group includes: carbodiimide, imines ester, aromatic yl azide (arylazide), diazomethane, hydroxyl first Base phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), Alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), azide, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate Ester, aziridine (aziridine), isocyanates, rhodanate, epoxide, toluene fulfonate (Tosylate), succinyl Imines, hydroxysuccinimide eater (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, Acrylic or methacrylic acid ester, two sulfonated bodies and ketone, but not limited to this.

In addition, above-mentioned protein may include the reactive residue of mercapto, hydroxyl, carboxyl or amino.

Above-mentioned carbodiimide compound is the total of the compound of the structure indicated in the molecule containing following chemical formula 1 Claim.

Chemical formula 1

- N=C=N-

Above-mentioned carbodiimide compound, preferably in the molecule containing the structure of 1 to 1000 or so chemical formula 1, more Preferably the intramolecular structure that contains 1 to 100 or so chemical formula 1, more preferably intramolecular contain 1 to 10 or so change The structure of formula 1.

In this case, when the structure of intramolecular chemical formula 1 is more than 1000, the viscosity of raw material is too big, molecular weight mistake Greatly, the reflecting point that can be reacted is excessive, and the molecule containing carbodiimide is very big, has blocked in the molecule with actual functional capability The part of functional effect is presented, thus the problem of luminous efficiency reduces.

In the present invention, it as the concrete example of carbodiimide compound, can enumerate, represented by following chemical formula 2 Compound, in following chemical formula 2, n 4, m be 11 compound be named as the bis- (1- isocyanate group -1- methyl of 1,3- Ethyl)-phenyl homopolymer, the mono- Methylethyl copolymer of polyethylene glycol is (hereinafter, the Form of Polymer carbodiimide class of chemical formula 2 Compound).

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

In the present invention, as other examples of carbodiimide compound, the change of the expression of following chemical formula 3 can be used Close object, 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide or 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide Hydrochloric acid.

Chemical formula 3

Ultraviolet light according to the present invention blocks the preference for using composition, and the ultraviolet light with carboxyl is blocked ingredient preparation At directly having the reactive reactive esters ultraviolet light of raw body to block into division aspect, either, by hair (17.5~ 21.9%), cornu cutaneum matter (15.5~23.5%), the amino acid (such as the aspartic acid, paddy ammonia that are present in excess in fiber (19~23%) Acid) reactivity esterification, the carbodiimide compound of target is capable of using the ultraviolet light blocking ingredient containing amino, preparation has Reactive ester form (reactive ultraviolet light blocking ingredient), thus intensified response efficiency, and then enhance its effect.In addition, also Intramolecular, which can be used, has such as carbodiimide, imines ester, aromatic yl azide (arylazide), diazomethane, methylol Phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), alkane As oxygroup amine, hydrazides, halogenation acetyl (Haloacetyl), azide etc. can with the functional group of target amino acid other Ultraviolet light blocks ingredient, can increase its effect.

Concrete example more preferably blocks the albumen of component molecules, skin or hair in the ultraviolet light with carboxyl On matter surface, firstly, using the carbodiimide compound of the Form of Polymer of chemical formula 2 or such as 1- ethyl -3- (3- diformazan Base aminopropyl) carbodiimide compound as carbodiimide hydrochloride carries out primary first-order equation generation of reactive ester, in generation Make again on reactive ester functional groups intramolecular have amino ultraviolet light block ingredient reaction, or with hair or skin surface Amino reaction, obtain outstanding ultraviolet light barrier effect.Above-mentioned reaction preferably carries out under conditions of pH2~10, more preferably It carries out under conditions of pH3~9, is most preferably reacted in the acid condition or slightly acidic water solution of pH4~5, can be increased anti- Answer efficiency.The reaction is completed in 1 to 30 minute.

Shown in following reaction equations 7, the ultraviolet light with carboxyl block component molecules and carbodiimide compound into Row primary first-order equation forms reactive ester, and then reacts with the amino acid of the raw body with amino residue, forms the reaction of covalent bond Ideograph.

Reaction equation 7

It is shown in following reaction equations 8, the raw body amino with carboxyl of the protein surface as hair, skin or fiber The aspartic acid and glutamic acid and carbodiimide compound primary first-order equation of acid, form reactive ester, so with amino The ultraviolet light of residue blocks ingredient reaction, forms the reaction pattern figure of covalent bond.

Reaction equation 8

By carbodiimide compound, what the protein of hair, skin or fiber and ultraviolet light blocked ingredient reacts effect Rate increases, and the reactive ultraviolet light being incorporated on hair, skin or fiber blocks ingredient will not be in shampoo, detergent, soap Deng conventional wash in be washed off, be almost able to maintain that the state for being permanently affixed to hair, skin or fiber.

Ultraviolet light of the invention blocks ingredient, can also comprising be combined with can be formed with protein covalent bond selected from by The ultraviolet light of the functional group of one or more of the group of following functional group's composition blocks ingredient, that is, carbodiimide, imines ester, virtue Base azide (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), Azide Object, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), isocyanates, rhodanate, ring Oxygen compound, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, sulphur Alcohol, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies, And ketone.

For example, may include such as above-mentioned reaction equation 1, make the generation of carbodiimide compound primary first-order equation is combined with carbon The ultraviolet blocking-up cosmetic composition of di-imidogen.It is also possible to comprising being hindered with above-mentioned reactive ultraviolet light The ultraviolet light blocking composition being broken into point.

Ultraviolet blocking-up cosmetic composition according to the present invention can be with palmitinic acid, stearic acid etc. in order to increase effect Fatty acid, fatty alcohol, linear chain or branched chain cationic surfactants, cationized cellulose, the sun such as long chain alkyl ammonium salt Cation type polymers, the silicon such as ionization guar gum, cationized polyvinyl yl pyridines alkanone are used in mixed way, to make formulation appearance Easily.In addition, for the dosage form of cosmetic formulations, can add solvent, surfactant, tackifier, stabilizer, preservative, Colorant, pH regulator, metal ion block agent, colorant, swelling agent, appearance investigation agent, pigment, seperated particle etc. are for changing The formulation ingredient of cosmetic.It can be used 40 to 99 relative to 100 parts by weight of all compositions for formulation ingredient Parts by weight.

Ultraviolet light blocking according to the present invention composition includes the ultraviolet light block function ingredient with functional group, can be with The formula for the composition that applies some make up is blocked for ultraviolet light.As the Application Example of skin products, protection skin is generally included Basic cosmetics (toner, essence, essence, lotion, face cream etc.), makeup cosmetic (sun screen, foundation cream, powder, eye shadow, lip Coloured silk, lipstick, lip gloss etc.), nail beautifier (have a manicure, nutritional agents, hardening agent, finishing coat etc.), cleaning, which applies some make up, (washes Face milk, makeup remover, make up remover, makeup removing frost, makeup removing gel, facial mask, mask, perfumed soap, towel of washing one's face etc.), sunscreen cosmetic, moisturizing Cosmetic (skin lotion, shower cream, skin cream, soothing oil etc.) may include shampoo, conditioning liquid, hair conditioner, hair for hair The all formulations such as film, daily hair treatment, wax, gel, spraying, in the case where fibre, fiber softener, liquid lotion, powder Last lotion, piece type lotion, fiber dyeing agent, fibre care agent, fiber purificant, bleaching agent, partial contamination inorganic agent, fiber are fixed The all formulations such as type agent, ironing aids, clothes safekeeping agent.

It is further preferred that while ultraviolet light blocking according to the present invention includes carbodiimide compound with composition, Ingredient is blocked comprising the ultraviolet light with reactive functional groups, in the case that activity of the above-mentioned preparation in water system reduces, Its activity is more easily maintained in non-water system dosage form, in order to adjust pH, is mixed with buffer, by washing process using preceding In the method that is contacted with water bring it about reaction.As the example of non-water system dosage form, can be as conventional non-water system cosmetics Preparation can be liquid, piece type, powder powder type, pastille type, oil, wax, injection (ampoule), gel etc..In addition, carbon two is sub- Aminated compounds and ultraviolet light block ingredient, two dosage forms that can be separated by the single formulation in the form of preparation formation capsule or respectively. Further, it is also possible to using by forming capsule, it will be with reactive functional group and with the ingredient knot of ultraviolet blocking-up function The method that the derivative and moisture of the form of conjunction block.

Ultraviolet light according to the present invention, which blocks, uses composition, has the effect of that the ultraviolet light of functional group blocks to increase, The 2- hydrochloric acid ester oils such as dioctyl succinate acid esters, d-octyl adipate, diethyl sebacate and polyol, poly- second two can be used Alcohol, propylene glycol, hexylene glycol, butanediol and their metamer, glycerine, benzyl alcohol, ethoxydiglycol and derivative Object.The above-mentioned solvent referred to, can increase the impregnability of hair, skin or fiber, and the solvent as slightly solubility substance uses. The activity of ingredient is blocked to maintain effect, it is preferable to use diethyl sebacate, ethoxy in order to increase the ultraviolet light with functional group Base diethylene glycol, double-ethoxy ethyl glycol hexamethylene, 1,4- dicarboxylic ester etc..

The present invention relates to a kind of raw body bonding compositions, are bonded into containing carbodiimide compound and raw body Point.

Raw body bonding composition according to the present invention, for example, being bonded into carbodiimide compound with known raw body Divide reaction, the raw body by combining carbodiimide engages ingredient, forms it between hair or the protein of skin Covalent bond, to reach the maximization of raw body splicing results.

The usage amount of above-mentioned carbodiimide compound is 0.001 to 10 relative to all compositions of 100 parts by weight Parts by weight, 0.01 to 7 parts by weight or 0.1 to 5 parts by weight.In the case that its content is less than 0.001 parts by weight, it is difficult to reach Lasting raw body splicing results have been more than reflecting point present in skin and have excessively existed in the case where more than 50 parts by weight Carbodiimide compound exist in the state of not with dermoreaction, to there are problems that can only being used as loss ingredient.

In the present invention, " raw body splicing results " refer to, there is the damaged part of the raw body tissue of skin or hair etc. more Effect quickly regenerates or is joined to original state, to prevent or improve skin damage or the function of hair bifurcated.

The raw body engagement ingredient being used in the present invention, may include: fibrin, albumin, Portugal (grape) osamine, N- acetyl glucosamine, alginate esters, hydrogel, growth factor, the physiological activity factor, necrotic tissue cleaning agent, fork hair cement, Antibacterial coating agent etc..As above-mentioned growth factor, for example, F GF (Fibroblast Growth Factor；At fibre Tie up Porcine HGF), KGF (Keratinocyte Gro wth Factor；Keratinocyte growth factor), VEGF (Vascular Endothelial Growth Fact or；Vascular endothelial growth factor), EGF (Epidermal Growth Factor；Epidermal growth factor), PD GF-AA (Platelet Derived Growth Factor AA；Platelet derived life The long factor), PDGF-A B (Platelet Derived Growth Factor AB；Platelet derived growth factor antibody), PDGF-B B(Platelet Derived Growth Factor BB；Platelet derived growth factor), TGF- (Transfor ming Growth Factor-；Transforming growth factor), TGF-, IGF (Insulin-like Growth Factor；Insulin Like growth factor), TNF (Tumor Necrosis Factor；Tumor necrosis factor), GM-CSF (G ranulocyte Macrophage Colony Stimulating Factor；Granulocyte macrophage colony stimulating factor), NGF (Nerve Growth Factor；Nerve growth factor) etc..As the above-mentioned physiological activity factor, interferon, red blood cell hematopoiesis can be enumerated The factor, 1L-1 (interleukin 1), 1L-2,1L-6,1L-8 etc..Cement is sent out as above-mentioned fork, N- (4- carboxylic can be enumerated Base -3- hydroxy phenyl) maleimide, transglutaminase etc..As above-mentioned antibacterial coating agent, can enumerate benzalkonium chloride, Benzethonium chloride (Benzetho nium Chloride), the chloro- 2- hydroxyl phenol of 2,4,4- tri-, triclosan (triclosan), triclocarban (triclocarban), isopropyl methyl phenol, pinon pine (pinyon), allantoin, epsilon-amino Caproic acid, Radix Glycyrrhizae acids etc..

The usage amount of above-mentioned raw body engagement ingredient is 0.001 to 50 weight relative to all compositions of 100 parts by weight Part, 0.001 to 30 parts by weight or 0.01 to 10 parts by weight or 0.1 to 5 parts by weight.When its content is less than 0.001 parts by weight In the case where, can not effectively play its performance, when content is more than 50 parts by weight, exist type and dosage form processed through Shi Wending Property and fail reaction as loss ingredient the problem of.

In particular, raw body engagement ingredient of the invention contains carboxyl or amino in the molecule, can be improved and carbodiimide The reaction efficiency of class compound.

In addition, containing and can be formed with the residue of protein of hair or skin surface in the ingredient of raw body engagement in the present invention The functional group of covalent bond.

The functional group that covalent bond can be formed with above-mentioned protein, which can be in the group as composed by following functional group, to be selected More than one, the functional group include: carbodiimide, imines ester, aromatic yl azide (arylazide), diazomethane, Methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater (sulfo-hydroxy succinimide Ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), azide, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrobenzene Base carbonic ester, aziridine (aziridine), isocyanates, rhodanate, epoxide, toluene fulfonate (Tosylate), Succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, mercaptan, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, Acrylic or methacrylic acid ester, two sulfonated bodies and ketone, but not limited to this.

In addition, above-mentioned protein may include the reactive residue of mercapto, hydroxyl, carboxyl or amino.

Above-mentioned carbodiimide compound is the total of the compound of the structure indicated in the molecule containing following chemical formula 1 Claim.

Chemical formula 1

- N=C=N-

Above-mentioned carbodiimide compound is, preferably the intramolecular structure that contains 1 to 1000 or so chemical formula 1, more Preferably the intramolecular structure that contains 1 to 100 or so chemical formula 1, more preferably intramolecular contain 1 to 10 or so change The structure of formula 1.

In this case, when the structure of intramolecular chemical formula 1 is more than 1000, the viscosity of raw material is too big, molecular weight mistake Greatly, the reflecting point that can be reacted is excessive, and the molecule containing carbodiimide is very big, has blocked in the molecule with actual functional capability The part of functional effect is presented, thus the problem of luminous efficiency reduces.

In the present invention, it as the concrete example of carbodiimide compound, can enumerate, represented by following chemical formula 2 Compound, in following chemical formula 2, n 4, m be 11 compound be named as the bis- (1- isocyanate group -1- methyl of 1,3- Ethyl)-phenyl homopolymer, the mono- Methylethyl copolymer of polyethylene glycol is (hereinafter, the Form of Polymer carbodiimide class of chemical formula 2 Compound).

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

In the present invention, as other examples of carbodiimide compound, the change of the expression of following chemical formula 3 can be used Close object, 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide or 1- ethyl -3- (3- dimethyl aminopropyl) carbodiimide Hydrochloric acid.

Chemical formula 3

Raw body engagement ingredient with carboxyl is prepared into directly by the preference of raw body bonding composition according to the present invention It connects and is bonded into division aspect with the reactive reactive esters raw body of raw body, either, by hair (17.5~21.9%), skin Amino acid (such as aspartic acid, glutamic acid) the reactivity esterification being present in excess in cutin (15.5~23.5%), using containing ammonia The raw body engagement ingredient of base is capable of the carbodiimide compound of target, is prepared into (the reactivity life of reactive ester form Body engages ingredient), thus intensified response efficiency, and then enhance its effect.Further, it is also possible to be had using intramolecular as carbon two is sub- Amine, imines ester, virtueization base, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxysuccinimide eater, alcoxyl The raw body for the functional group for capableing of target amino acid as base amine, hydrazides, halogenation acetyl (Haloacetyl), azide etc. connects Synthesis point, can increase its effect.

Concrete example more preferably engages the protein of component molecules, skin or hair in the raw body with carboxyl On surface, firstly, using the carbodiimide compound of the Form of Polymer of chemical formula 2 or such as 1- ethyl -3- (3- dimethyl Aminopropyl) carbodiimide compound as carbodiimide hydrochloride carries out primary first-order equation generation of reactive ester, in the anti-of generation Make intramolecular that there is the raw body engagement ingredient reaction of amino, or the ammonia with hair or skin surface on answering property ester functional groups again Base reaction, obtains outstanding raw body splicing results.Above-mentioned reaction preferably carries out under conditions of pH2~10, more preferably pH3~ It is carried out under conditions of 9, is most preferably reacted in the acid condition or slightly acidic water solution of pH4~5, reaction efficiency can be increased. The reaction is completed in 1 to 30 minute.

It is shown in following reaction equations 9, the aspartic acid and paddy ammonia of skin or hair proteins with carboxyl terminal Acid with carbodiimide compound carry out primary first-order equation, formed reactive ester, and then with skin or hair with amino residue The reaction of lysine present in protein, forms the reaction pattern figure of covalent bond.

Reaction equation 9

Following reaction equations 10 show, the protein of skin and hair comprising amino acid cysteine, an intramolecular are simultaneously Malaysia acyl with carboxylic acid residues and as raw body reactive group under conditions of pH7-8 in conjunction with the cysteine of raw body amino acid The raw body mating substance of imines and 1- ethyl -3- (3- dimethyl aminopropyl) carbon two as carbodiimide compound are sub- Amine carries out primary first-order equation generation of reactive ester, and passes through the scalp of reactive ester generated and the lysine of hair The raw body engaged mode figure of the amino reaction of (lysine amino acid).

Reaction equation 10

By carbodiimide compound, the reaction efficiency that the protein of hair or skin engages ingredient with raw body increases, The reactive raw body engagement ingredient being incorporated on hair or skin will not be washed off in the conventional wash of shampoo, soap etc., Almost it is able to maintain that the state for being permanently attached to hair or skin.

Raw body of the invention engages ingredient, can also comprising be combined with can be formed with protein covalent bond selected from following The reactive raw body of the above functional group of at least one of the group of functional group's composition engages ingredient, and the functional group includes: carbon two Imines, imines ester, aromatic yl azide (arylazide), diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, thio-hydroxyl Base succinimide ester (sulfo-hydroxy succinimide ester), alkoxyamine, hydrazides, halogenation acetyl (Haloacetyl), azide, carbonic ester, aldehyde, propionic aldehyde, butyraldehyde, nitrophenyl carbonate, aziridine (aziridine), different Cyanate, rhodanate, epoxide, toluene fulfonate (Tosylate), succinimide, hydroxysuccinimide eater (hydroxysuccinimidyl ester), imidazoles, Epoxide carbonyl imidazoles (Oxycarbonylimidazole), imines, sulphur Alcohol, maleimide, vinyl sulfone, ketene imine, thioether, acrylonitrile, acrylic or methacrylic acid ester, two sulfonated bodies, And ketone.

For example, may include such as above-mentioned reaction equation 1, make the generation of carbodiimide compound primary first-order equation is combined with carbon The raw body of di-imidogen engages ingredient.It is also possible to include the raw body with above-mentioned reactive raw body engagement ingredient Bonding composition.

Raw body bonding composition according to the present invention can be fatty with palmitinic acid, stearic acid etc. in order to increase effect Acid, fatty alcohol, linear chain or branched chain cationic surfactants, cationized cellulose, the cation such as long chain alkyl ammonium salt Change cation type polymers, the silicon such as guar gum, cationized polyvinyl yl pyridines alkanone to be used in mixed way, to make formulation be easy. In addition, for type processed, can add solvent, surfactant, tackifier, stabilizer, preservative, colorant, pH regulator, Metal ion blocks agent, colorant, swelling agent, appearance investigation agent, pigment, seperated particle etc. and is used for formulation ingredient.For 40 to 99 parts by weight can be used relative to 100 parts by weight of all compositions in formulation ingredient.

Raw body bonding composition according to the present invention includes the raw body engagement function ingredient with functional group, Ke Yiyong In the formula that raw body engagement applies some make up composition.As the example of hair product, before can be used for having one's hair wash (pre-shampoo) Composition, shampoo, hair care maintenance element, pomade, spraying (spray), mousse (mousse), hair nursing liquid, essence, hair Cream, permanent hair dye, interim hair dye, agent for permanent hair waving, non-woven fabrics, sheet material etc. generally include to protect for skin product The basic cosmetics (toner, essence, essence, lotion, face cream etc.) of skin, makeup cosmetic (sun screen, foundation cream, powder, Eye shadow, lip gloss, lipstick, lip gloss etc.), nail beautifier (have a manicure, nutritional agents, hardening agent, finishing coat etc.), cleaning makeup Product (facial cleanser, makeup remover, make up remover, makeup removing frost, makeup removing gel, facial mask, mask, perfumed soap, towel of washing one's face etc.), sunscreen cosmetic, Moisturizing cosmetics (skin lotion, shower cream, skin cream, soothing oil etc.).

It is further preferred that while raw body bonding composition according to the present invention includes carbodiimide compound, packet Ingredient is engaged containing the raw body with reactive functional groups, in the case that activity of the above-mentioned preparation in water system reduces, is more held Its activity is easily maintained in non-water system dosage form, in order to adjust pH, is mixed with buffer, or by washing process using preceding The method contacted with water brings it about reaction.As the example of non-water system dosage form, the system as conventional non-water system cosmetics can be Agent, can be liquid, piece type, powder powder type, pastille type, oil, wax, injection (ampoule), gel etc..In addition, carbon two is sub- Aminated compounds and raw body engage ingredient, two dosage forms that can be formed the single formulation of gel form with preparation or separate respectively.This Outside, the ingredient with reactive functional group and with raw body engagement function can also be combined using by forming gel The method that the derivative and moisture of form block.

Raw body bonding composition according to the present invention can be in order to increase the raw body engagement with functional group Using the 2- hydrochloric acid ester oils such as dioctyl succinate acid esters, d-octyl adipate, diethyl sebacate and polyol, polyethylene glycol, Propylene glycol, hexylene glycol, butanediol and their metamer, glycerine, benzyl alcohol, ethoxydiglycol and derivative.On The solvent referred to is stated, the impregnability of hair or skin can be increased, the solvent as slightly solubility substance uses.Have to increase Functional group raw body engagement ingredient activity maintain effect, it is preferable to use diethyl sebacate, ethoxydiglycol, it is double- Ethoxy ethyl glycol hexamethylene, 1,4- dicarboxylic ester etc..

Specific kenel for implementation

In the following, according to embodiment and experimental example, the present invention will be described in detail.But following embodiments and experimental example are only A kind of example of the invention, the present invention is not limited to the following examples and experimental example.

Examples 1 to 5 and comparative example 1~2: coloring composition

According to composition shown by following table 1 and content, the coloring agent of Examples 1 to 5 and comparative example 1~2 is prepared Composition impregnates in the composition 10g of preparation and forms very similar white consumption ox hair and wool fiber with protein (wool) (5cm*5cm) reacts after ten minutes at 25 DEG C, primary using water displacement wash, does after washed once using shampoo It is dry, compare a* value (red), b* value (blue) using colour difference meter measurement, compares the amount of dye of initial reaction, for same treatment Consumption ox hair and wool fiber handle the washing of 10 shampoos and cleaning step repeatedly, and after drying, colour difference meter is used to measure ratio Compared with a* value, b* value, the duration effect of reaction is thereby confirmed that.(experiment of comparative example 1 and embodiment 1 uses consumption ox hair, comparative example 2 and embodiment 3~5 experiment use wool fiber).

Table 1

The experimental result (table 2) of above-described embodiment 1~5 and comparative example 1~2, not used as raw body reactive group The Comparative Examples 1 and 2 that the dyestuff not comprising carbodiimide of substituted dyestuff implements dyeing is compared, and raw body reactivity base has been used The embodiment 1 of the substituted derivative of group, then be evaluated as dyeability and duration be excellent, carbodiimide compound and dyestuff Reaction, the embodiment 2~5 prepared by the chemically-reactive dyes of generation, due to forming the covalent bond of carbodiimide, to show More excellent dyeability and duration, in particular, embodiment 4 to 5, the carbon of the chemical formula 2 used as polymer morphology Diimine class compound shows most excellent dyeability and dyeing lasting effect.

Table 2

Fig. 1 shows and dyes under above-mentioned condition, the colored state of the consumption ox hair of comparative example 1 and embodiment 1 after hair washing ten times.

Fig. 2 shows being dyed under above-mentioned condition, the wool for primary embodiment 4 and embodiment 5 afterwards, after hair washing ten times of having one's hair wash The colored state of fiber.

Embodiment 6~12 and comparative example 3~5: Hydra composition

According to composition shown by following Table 3 and content, the moisturizing of embodiment 6~12 and comparative example 3~5 is prepared It is applied on 10 good hairs of 5g beam, is put at normal temperature respectively using the composition 10g prepared in each example with composition The reaction of induction in 30 minutes is set, it is primary using water displacement wash, reuse 15% laureth sodium sulfovinate aqueous solution (SLES) Dry after hair washing is primary, the process is repeatedly primary.Then, wherein 1g hair is taken, using dry weight reduction scale, at a temperature of 60 degree quantitative Amount of moisture as moisture-holding capacity, ten processes dry using SLES15% aqueous cleanings, take wherein 1g hair repeatedly, utilize Weight reduction scale is dried, the amount of moisture under 60 degree is quantified, confirms the duration of moistening effect.

Table 3

The experimental result (table 4) of above-described embodiment 6~12 and comparative example 3~5, is not taken as raw body reactive group The comparative example 3~5 that the moisturizing ingredient in generation does not include carbodiimide is compared, and the substituted derivative of raw body reactive group has been used Embodiment 6, then be evaluated as moisture retention and duration be excellent, raw body reactive group is unsubstituted and contains carbodiimide Embodiment 7 to 12, due to forming the covalent bond of carbodiimide, so that the more excellent moisture retention and duration of display, special It is not the embodiment 10~12 for having used carbodiimide quasi polymer, shows most excellent moisture retention and moisturizing lasting effect.

Table 4

Preparation example 1: the preparation of moisturizing hair nursing water

Using conventional cosmetic preparation method, moisturizing cosmetic is prepared by the ingredient and content of following table 5.

Table 5

Embodiment 13~19 and comparative example 6~8: composition is used in nursing

According to composition shown by following table 6 and content, the hair of embodiment 13~19 and comparative example 6~8 is prepared Nursing composition is applied on the wisp of hair of 4g respectively, is put at normal temperature using the composition 10g prepared in each example The reaction of induction in 30 minutes is set, washed once using flowing water and shampoo, compare the nursing efficacy at initial stage.Later, one is had one's hair wash daily Secondary, after being evaluated ten days according to 5 points of appraisement systems (5 points: very outstanding of nursing efficacy；4 points: more outstanding；3 points: not changing；2 Point: there is no effect；1 point: without a bit effect).

Table 6

The experimental result (table 7) of above-described embodiment 13~19 and comparative example 6~8, as raw body reactive group not by Substituted nursing compositions do not include the comparative example 6~8 that carbodiimide is nursed and compare, and raw body reactive group has been used to be taken The embodiment 13 of the derivative in generation, then be evaluated as nursing efficacy and duration is excellent, raw body reactive group it is unsubstituted and Embodiment 14 to 19 containing carbodiimide, due to forming the covalent bond of carbodiimide, thus the nursing effect that display is more excellent Fruit and duration show most excellent nursing efficacy in particular, having used the embodiment 17~19 of carbodiimide quasi polymer And nursing lasting effect.

Table 7

Embodiment 20~26 and comparative example 9~11: composition is used in nursing

According to composition shown by following table 8 and content, the head of embodiment 20~26 and comparative example 9~11 is prepared Hair nursing composition is applied on the wisp of hair of 4g or so, using the composition 10g prepared in each example normal respectively Temperature is lower to place the reaction of induction in 30 minutes, washed once using flowing water and shampoo, compares the nursing efficacy at initial stage.Later, daily Hair washing is primary, (5 points: very outstanding of nursing efficacy after evaluating ten days according to 5 points of appraisement systems；4 points: more outstanding；3 points: not having Variation；2 points: there is no effect；1 point: without a bit effect).

Table 8

The experimental result (table 9) of above-described embodiment 20~26 and comparative example 9~11, as raw body reactive group not by Substituted nursing compositions, the comparative example 9~11 not comprising carbodiimide are compared, and have used raw body reactive group is substituted to spread out The embodiment 20 of biology, then be evaluated as nursing efficacy and duration be excellent, raw body reactive group is unsubstituted and contains carbon The embodiment 21 to 26 of diimine, due to forming the covalent bond of carbodiimide, thus the more excellent nursing efficacy of display and Duration, in particular, showing most excellent nursing efficacy and nursing using the embodiment 24~26 of carbodiimide quasi polymer Lasting effect.

Table 9

Embodiment 27~30 and comparative example 12~13: composition is used in nursing

According to composition shown by following table 10 and content, embodiment 27~30 and comparative example 12~13 are prepared Hair nursing composition is applied on the wisp of hair of 4g or so respectively using the composition 10g prepared in each example, The reaction of induction in 30 minutes is placed under room temperature, the process washed for the first time using flowing water and shampoo, the Jing Liangtian time, with daily 2 It is secondary to wash repeatedly, the painting coating and swelling sense of hair after relatively dry processing.Later, hair washing is primary daily, evaluates according to 5 points The coating of hair after system appraisal 15 days and (5 points: very outstanding of swelling effect；4 points: more outstanding；3 points: not becoming Change；2 points: there is no effect；1 point: without a bit effect).

Table 10

Experimental example

The experimental result (table 11) of above-described embodiment 27~30 and comparative example 12,13, using do not include carbodiimide and Comparative example 12,13 comprising polymer is compared, the embodiment 27~30 containing carbodiimide, due to forming the covalent of carbodiimide Key, thus the hair swelling effect that display is more excellent, in particular, the embodiment 29,30 using carbodiimide quasi polymer is aobvious Show most excellent hair swelling effect.

Table 11

Preparation example 2: hair conditioner hair product manufacturing

Product is prepared according to the ingredient and content of following table 12 according to the preparation method of conventional hair product.

Table 12

Embodiment 31~38 and comparative example 14~17: composition is used in ultraviolet light blocking

According to composition shown by following table 13 and content, embodiment 31~38 and comparative example 14~17 are prepared Ultraviolet light is blocked is applied to the back of ten testers, normal using the composition 3g prepared in each example with composition respectively Temperature is lower to place the reaction of induction in 30 minutes, is washed off using flowing water, is washed off for the first time using perfumed soap, the process of drying process, a natural gift The morning and afternoon smear twice, and the process two days repeatedly, after having spent five days, continuous three days ultraviolet in the partial illumination of smearing daily Line 5 minutes, effect is prevented according to 5 points of appraisement system evaluation ultraviolet lights, to confirm that ultraviolet light prevents substance because raw body is reacted, is kept Prolonged ultraviolet light prevents (5 points: very outstanding of effect；4 points: more outstanding；3 points: not changing；2 points: there is no effect；1 point: There is no a bit effect).

Table 13

The experimental result (table 14) of above-described embodiment 31~38 and comparative example 14~17, the comparison not comprising carbodiimide Example 14~17 is compared, the embodiment 31~38 containing carbodiimide, due to forming the covalent bond of carbodiimide, so that display is more Excellent ultraviolet light blocking property and duration, in particular, display is most using the embodiment 35~38 of carbodiimide quasi polymer Excellent ultraviolet light blocking property and duration.

Table 14

Preparation example: ultraviolet light blocks the preparation to apply some make up

According to conventional cosmetics preparation method, ultraviolet light is prepared according to the ingredient and content of table 15 and is blocked with makeup Product.

Table 15

Embodiment 39~40 and comparative example 18: raw body bonding composition

According to composition shown by following table 16 and content, the hair for preparing embodiment 39,40 and comparative example 18 is connect Polymeric composition is applied to the bifurcation of 20 furcation area hairs, at normal temperature using the composition 3g prepared in each example respectively Place the reaction of induction in 30 minutes, washed off for the first time using flowing water and shampoo, continuous three days of the process daily repeatedly twice after, than Compared with the number of the hair of engagement.

Table 16

Embodiment 41~42 and comparative example 19: raw body bonding composition

According to composition shown by following table 17 and content, the hair for preparing embodiment 41,42 and comparative example 19 is connect Polymeric composition is uniformly applied to the bifurcation of 20 furcation area hairs respectively, is used flowing water using 1 dose of composition 3g of preparation After washing, using 2 doses of composition 3g of preparation, it is uniformly applied to the bifurcation of bifurcated hair respectively, places 30 at normal temperature Minute induce reaction, washed off for the first time using flowing water and shampoo, continuous three days of the process daily repeatedly twice after, compare engagement Hair number.

Table 17

The experimental result (table 18) of above-described embodiment 39~42 and comparative example 18,19, contains not comprising carbodiimide The comparative example 18 of ε-aminocaproic acid is compared, and the embodiment 39~40 comprising carbodiimide forms the covalent bond of carbodiimide, thus More excellent hair splicing results are shown, in particular, showing most excellent using the embodiment 40 of carbodiimide quasi polymer Hair splicing results.

In addition, having used N- (4- carboxyl -3- hydroxy-pheny) Malaysia of intramolecular with carboxyl and dimaleoyl imino In imido situation, the same excellent hair of the also available and embodiment 41,42 containing carbodiimide compound Splicing results.

Hair state before and after the processing for above-mentioned composition is shown in Fig. 3.

Table 18

Preparation example 4: raw body engages the preparation to apply some make up

It prepares raw body according to the ingredient and content of following table 19 according to conventional cosmetics preparation method and engages useization Cosmetic.

Table 19

Claims (37)

1. a kind of coloring composition, wherein including carbodiimide compound and dyestuff,

The carbodiimide compound is carbodiimide compound represented by following chemical formula 2,

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

2. coloring composition according to claim 1, wherein above-mentioned dyestuff contains carboxyl or amino in the molecule.

3. coloring composition according to claim 1, wherein above-mentioned dyestuff is natural dye or synthetic dyestuffs.

4. coloring composition according to claim 3, wherein above-mentioned natural dye is alizarinopurpurin, purple alizarin pigment, black The presoma of element or melanin.

5. coloring composition according to claim 3, wherein above-mentioned synthetic dyestuffs are redness of the skin or complexion 3, redness of the skin or complexion 104, red Color 105, redness of the skin or complexion 201, redness of the skin or complexion 202, redness of the skin or complexion 220, redness of the skin or complexion 230, redness of the skin or complexion 231, redness of the skin or complexion 232, redness of the skin or complexion 401 Number, redness of the skin or complexion 405, yellow 4, yellow 202, No. 207 orange, redness of the skin or complexion 106, redness of the skin or complexion 213, redness of the skin or complexion 214, redness of the skin or complexion No. 215, yellow 404, yellow 405, cyan 403, disperse blue 1, disperse orange 3, dispersion be black 9, HC indigo plant 2, HC are red 3, HC Huang 5 Or HC red 1.

6. coloring composition according to claim 1, wherein above-mentioned dyestuff have can with hair, skin, fiber or The residue of protein of leather surface forms the functional group of covalent bond.

7. coloring composition according to claim 6, wherein the functional group for forming covalent bond with above-mentioned protein is choosing From carbodiimide, imines ester, aromatic yl azide, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, alkoxyamine, acyl Hydrazine, halogenation acetyl, azide, carbonic ester, aldehyde, aziridine, isocyanates, rhodanate, epoxide, toluenesulfonic acid Salt, succinimide, imidazoles, imines, mercaptan, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic or methacrylic One or more of acid esters, two sulfonated bodies and group of ketone composition.

8. coloring composition according to claim 1, wherein relative to all compositions of 100 parts by weight, the carbon Diimine class compound is 0.001 to 10 parts by weight.

9. coloring composition according to claim 1, wherein the carbodiimide compound and dye formulations plastic The single formulation of scrotiform state, alternatively, preparation separates two dosage forms of kenel at carbodiimide compound and dyestuff respectively.

10. a kind of moisture-keeping cosmetic composition, wherein including carbodiimide compound and moisturizing ingredient,

The carbodiimide compound is carbodiimide compound represented by following chemical formula 2,

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

11. moisture-keeping cosmetic composition according to claim 10, wherein above-mentioned moisturizing ingredient contains carboxylic in the molecule Base or amino.

12. moisture-keeping cosmetic composition according to claim 10, wherein above-mentioned moisturizing ingredient be selected from by glycerol, Propylene glycol, butanediol, dipropylene glycol, pungent ethylene glycol, diglycerol, methyl gluceth, ethoxy ethyl glycol, glyceryl alcohol, two Ethoxydiglycol 2-pyrrolidone-5-carboxylic acid, sodium lactate, pyrrolidone sodium carboxylate, mineral oil, vaseline, lanolin, lotus fragrant plant oil, Olive oil, glycosphingolipid, phosphatide, lipid mixture, isononyl isononanoate, glycine betaine, carboxymethyl chitosan, ceramide, glucose Amine polysaccharide, alpha-glucans, hyaluronic acid, hydrolysis hyaluronic acid, chitosan, chitosan succinamide, vitamin E, Urea, hydroxy ethyl urea, glucose glycoside, γ-PGA, xylitol, pentaerythritol tetraoctyl stearate, chondroitin sulfate Sodium, chondroitin-4-suleate lack atelocollagen, beta glucan, PEG, three-hexyldecanoic acid of pyridoxine ester, 2-pyrrolidone-5-carboxylic acid's potassium, gather Gamma-glutamic acid sodium, polyacrylic acid glycerol ester, pine tree polysaccharide, -3 cross-linked copolymer of polyglycereol, Sodium Hyaluronate, double-PEG-18 first Base ether dimethylsilane, double-ethoxydiglycol succinate, Ascorbyl Tetraisopalmitate, glycosyl trehalose, hydrogenation Glucidtemns, 1,2- hexylene glycol, mannitol, arginine, serine, sucrose, PCA, citrulling, glycogen, histidine hydrochloride, Alanine, threonine, glutamic acid, lysine hydrochloride, phosphate buffer normal saline, creatine, cholesterol isostearate, cholesteric Alcohol chloride, cholesteryl nonanoate, BHT, two (lauramide glutamine) Sodium lysinates, maltodextrin, polyquaternium -39, Vitamin D3 PEG-12 ester, carbohydrate isomer, D-sorbite and they derivative composition group more than one.

13. moisture-keeping cosmetic composition according to claim 10, wherein above-mentioned moisturizing ingredient has can be with hair Or the residue of protein of skin surface forms the functional group of covalent bond.

14. moisture-keeping cosmetic composition according to claim 13, wherein form the official of covalent bond with above-mentioned protein It can roll into a ball as selected from by carbodiimide, imines ester, aromatic yl azide, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, alkane Oxygroup amine, hydrazides, halogenation acetyl, azide, carbonic ester, aldehyde, aziridine, isocyanates, rhodanate, epoxide, Toluene fulfonate, succinimide, imidazoles, imines, mercaptan, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or One or more of methacrylate, two sulfonated bodies and group of ketone composition.

15. moisture-keeping cosmetic composition according to claim 10, wherein the whole combination relative to 100 parts by weight Object, the carbodiimide compound are 0.001 to 10 parts by weight.

16. moisture-keeping cosmetic composition according to claim 10, wherein the carbodiimide compound and moisturizing Component preparation at capsule shape state single formulation, alternatively, preparation separates respectively at carbodiimide compound and moisturizing ingredient Two dosage forms of kenel.

17. a kind of nursing applies some make up composition, wherein including carbodiimide compound and nursing compositions,

The carbodiimide compound is carbodiimide compound represented by following chemical formula 2,

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

The composition 18. nursing according to claim 17 applies some make up, wherein above-mentioned nursing compositions contain carboxylic in the molecule Base or amino.

The composition 19. nursing according to claim 17 applies some make up, wherein above-mentioned nursing compositions are to select free polymer In the group that class, fatty amines, silicon class, fatty alcohols, fatty acid, paraffin class, ester oil class and their derivative form More than one.

The composition 20. nursing according to claim 17 applies some make up, wherein above-mentioned nursing compositions have can be with hair Or the residue of protein of skin surface forms the functional group of covalent bond.

The composition 21. nursing according to claim 20 applies some make up, wherein the official of covalent bond is formed with above-mentioned protein Can roll into a ball is selected from by carbodiimide, imines ester, aromatic yl azide, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, alkane Oxygroup amine, hydrazides, halogenation acetyl, azide, carbonic ester, aldehyde, aziridine, isocyanates, rhodanate, epoxide, Toluene fulfonate, succinimide, imidazoles, imines, mercaptan, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or One or more of methacrylate, two sulfonated bodies and group of ketone composition.

The composition 22. nursing according to claim 17 applies some make up, wherein the whole combination relative to 100 parts by weight Object, the carbodiimide compound are 0.001 to 10 parts by weight.

The composition 23. nursing according to claim 17 applies some make up, wherein the carbodiimide compound and nursing Component preparation at capsule shape state single formulation, alternatively, preparation separates respectively at carbodiimide compound and nursing compositions Two dosage forms of kenel.

24. a kind of ultraviolet light, which blocks, uses composition, wherein ingredient is blocked including carbodiimide compound and ultraviolet light,

The carbodiimide compound is carbodiimide compound represented by following chemical formula 2,

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

25. ultraviolet light according to claim 24, which blocks, uses composition, wherein above-mentioned ultraviolet light blocks ingredient in the molecule Contain carboxyl or amino.

26. ultraviolet light according to claim 24, which blocks, uses composition, wherein above-mentioned ultraviolet light block ingredient be selected from by Cinnamic acid, glyceryl p-aminobenzoate, drometrizole, galloyl gallate trioleate, 3- (4- methyl benzyl alkene)- Camphor, Anthranilate, Benzophenone -3, Benzophenone -4, Benzophenone -8, Uvinul BMBM, methoxy osmanthus second Ester, adenosine, octocrylene, octyldimethyl p-aminobenzoic acid, octyl methoxycinnamate, salicylic acid Monooctyl ester, octyl triazone, p-aminobenzoic acid, 2- benzimidazole -5- sulfonic acid, heliophan, zinc oxide, titanium dioxide Titanium, isopentyl-p- Methoxycinnamate, bis-ethylhexoxyphenol methoxyphenyl triazine, two benzimidazole sulphonic acid ester of phenylene Sodium salt, amodi- Ethylhexysalicylate, Diethylhexyl Butamido Triazon, Dimethicodiethylbenzalmalonate (benzal malonic acid Salt polysiloxanes), Methylen Bis-Benzotriazolyl, Terephthalidene Dicamphor Sulfonic Acid and its salt composition One or more of group.

27. ultraviolet light according to claim 24, which blocks, uses composition, wherein above-mentioned ultraviolet light blocks ingredient to have can The functional group of covalent bond is formed with the residue of protein of hair, skin or fiber surface.

28. ultraviolet light according to claim 27, which blocks, uses composition, wherein form the official of covalent bond with above-mentioned protein Can roll into a ball is selected from by carbodiimide, imines ester, aromatic yl azide, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, alkane Oxygroup amine, hydrazides, halogenation acetyl, azide, carbonic ester, aldehyde, aziridine, isocyanates, rhodanate, epoxide, Toluene fulfonate, succinimide, imidazoles, imines, mercaptan, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or One or more of methacrylate, two sulfonated bodies and group of ketone composition.

29. ultraviolet light according to claim 24, which blocks, uses composition, wherein the whole combination relative to 100 parts by weight Object, above-mentioned carbodiimide compound are 0.001 to 10 parts by weight.

30. ultraviolet light according to claim 24, which blocks, uses composition, wherein above-mentioned carbodiimide compound and ultraviolet Line blocks component preparation at the single formulation of capsule shape state, alternatively, preparation is blocked at carbodiimide compound and ultraviolet light Ingredient separates two dosage forms of kenel respectively.

31. a kind of raw body bonding composition, wherein ingredient is engaged including carbodiimide compound and raw body,

The carbodiimide compound is carbodiimide compound represented by following chemical formula 2,

Chemical formula 2

In above-mentioned chemical formula 2, n is that 1 to 100, m is 1 to 100.

32. raw body bonding composition according to claim 31, wherein above-mentioned raw body engagement ingredient contains in the molecule Carboxyl or amino.

33. raw body bonding composition according to claim 31, wherein above-mentioned raw body engagement ingredient is to select free-fiber It is albumen, albumin, Portugal (grape) osamine, n- acetyl glucosamine, alginate esters, hydrogel, growth factor, the physiological activity factor, bad One or more of dead tissue scavenger, fork hair cement and group of antibacterial coating agent composition.

34. raw body bonding composition according to claim 31, wherein above-mentioned raw body engagement ingredient has can be with head The residue of protein of hair or skin surface forms the functional group of covalent bond.

35. raw body bonding composition according to claim 34, wherein form the function of covalent bond with above-mentioned protein Group is selected from by carbodiimide, imines ester, aromatic yl azide, diazomethane, methylol phosphorus, pentafluorophenyl esters, pyridine sulphur, alcoxyl Base amine, hydrazides, halogenation acetyl, azide, carbonic ester, aldehyde, aziridine, isocyanates, rhodanate, epoxide, first Benzene sulfonate, succinimide, imidazoles, imines, mercaptan, maleimide, vinyl sulfone, thioether, acrylonitrile, acrylic acid or first One or more of base acrylate, two sulfonated bodies and group of ketone composition.

36. raw body bonding composition according to claim 31, wherein relative to all compositions of 100 parts by weight, Above-mentioned carbodiimide compound is 0.001 to 10 parts by weight.

37. raw body bonding composition according to claim 31, wherein carbodiimide compound and raw body are bonded into Divide preparation at the single formulation of gel form, alternatively, preparation divides respectively at carbodiimide compound and raw body engagement ingredient Two dosage forms of release state.