JP2018012732A - Composition containing carbodiimide-based compound - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide, among others, a dye composition capable of persistently imparting a semi-permanent dyeing effect without damaging the skin, hair, fiber or leather.SOLUTION: The present invention relates to a dye composition, a moisturizing cosmetic composition, a conditioning cosmetic composition, a UV ray blocking composition and a bioconjugate composition that contain a carbodiimide-based compound. The composition according to the present invention contains an active ingredient having a specific functional group capable of covalently bonding to protein residues on the surfaces of skin, hair, or fiber, thereby covalently bonding without damaging the skin, hair, or fiber so as to semi-permanently provide a desired effect.SELECTED DRAWING: Figure 2

Description

  The present invention relates to a staining composition containing a carbodiimide-based compound, a moisturizing cosmetic composition, a conditioning cosmetic composition, an ultraviolet blocking composition, and a biobonding composition.

  Generally, hair dyes, that is, hair dyes, are permanent hair dyes (oxidized hair dyes) and semi-permanent hair dyes (non-oxidative hair dyes) depending on the durability of the colored color and the characteristics of the composition. ) And temporary colorants. In the case of oxidation type hair dyes, low molecular weight oxidation dyes or pigments cause an oxidative polymerization reaction in the hair to form pigments, and various colors can be obtained. Is the most widely used type of hair dye. Such an oxidized hair dye composition contains one or more dyes or pigment precursors and one or more couplers that form a dye or pigment by being oxidized by an oxidizing agent, and such an oxidation hair dye composition. The hair dye composition for dyeing is used by being mixed with an oxidizing agent comprising a diluted hydrogen peroxide solution or the like immediately before being applied to the hair. The purpose of using such a hair dye is to dye the hair as completely as possible and to maintain the hair dyeing effect for a long time. In addition, the non-oxidative hair dye is a hair dye useful for providing hair with a natural color close to the primary color, and since hair damage is relatively small, it can be easily performed simultaneously with the permanent, Its utilization is gradually expanding. However, hair dyes currently on the market tend to discolor due to repetitive shampooing when dyeing with a bright hue, especially in the case of oxidized hair dyes, the action of oxidizing agents such as hydrogen peroxide. In the process of decolorizing hair, the disulphide bond (SS) in the hair is broken, causing severe damage to the hair, and the touch of the dyed hair becomes worse than that of healthy hair, and the dullness of the hair is reduced. have.

  In general, moisturizing cosmetics are cosmetics that have the function of preventing damage such as cracking and roughening by maintaining normal moisture in human skin and hair, etc. say. Such moisturizing cosmetics can be applied to the body, spread, etc. to beautify the skin and hair through normal moisture maintenance, increase appeal, change appearance or keep the skin healthy It is intended to be used in a manner similar to these. In addition, quasi-drugs, even if they act on the human body, have a minor effect and are not used for the treatment or prevention of disease, but also have a purpose of use that affects the structure and function of the body. It is defined as not.

  Moisturizing cosmetics generally include some basic moisturizing cosmetics for organizing and protecting the skin, including bases, points, limb nails, makeup moisturizing cosmetics and cleaning, sun care, tanning and other body moisturizing cosmetic products. .

  In general, when the moisture content of skin, hair and fibers is low, in the case of skin, the skin is dried, cracked and roughened. In addition, scales are generated on the surface of the skin, often accompanied by itching. Moreover, dry skin is easily infected with bacteria and fungi, and when the skin is extremely severely dried is called dry skin. However, when the skin is moisturized, it is possible to protect the skin by preventing damage caused by drying of the skin, preventing the thin lipid film on the skin surface from being directly exposed to external contaminants. Also, if the skin is moist, it may appear soft and lively, part of the fine lines appear to be hidden, and the effect of making pores appear small may be obtained.

  Such a moisturizing agent is a component that mixes well with water and maintains the moisture content of the stratum corneum through hydrogen bonding when applied to the skin, and functions as a moisturizing agent and a natural moisturizing factor similar to sebum. Can be broadly classified into moisturizers, general organic compound moisturizers, ceramides, and lamellas that are structurally lamellar and have a moisturizing effect.

  If moisturizers are classified according to their functions, skin moisturizers that have functions similar to natural moisturizing factors are substances that have a strong affinity for moisture, and draw moisture from their surroundings to maintain moisture. To function. The most typical skin wetting agent is glycerin, which functions to suppress water loss in the epidermis by penetrating into the stratum corneum and forming tight bonds with proteins and lipids in the stratum corneum. However, in a dry environment, the moistening agent absorbs moisture from the skin and can further dry the skin, which has a disadvantage that the effect is inferior to the skin sealant. Examples of such skin wetting agents include glycerin, propylene glycol, pyrrolidone carboxylic acid, sodium lactate, urea and the like.

  A skin sealant having a function similar to sebum is an oily substance, forms a water-impermeable film that does not allow water to permeate on the surface of the skin, and plays a role similar to a cortex film of normal skin. When used in a state where moisture has been supplied to the skin in advance through face washing or the like, the supplied moisture can be maintained for a long time, which can be more effective. Various substances such as mineral oil, petrolatum, lanolin, jojoba oil, olive oil, and lipid mixtures are used as substances used as such skin sealants. However, some skin sealants are sticky and greasy and may be inconvenient during and after use.

  Recently, the importance of stratum corneum lipids in the stratum corneum has been emphasized, and many studies and commercialization of moisturizing ingredients containing ceramide have been advanced. As a result, it was confirmed that when ceramide, cholesterol, and fatty acid were mixed at an appropriate ratio and applied to the skin, the damaged skin was recovered and had a moisturizing function.

  In addition, many studies have been conducted on increasing the moisturizing effect using structures such as emulsions and lamellar layered structures, and the W / O dosage form moisturizing agent is actually more effective than the O / W type moisturizing agent. However, many O / W dosage form moisturizing products are on the market from the standpoint of ease of manufacture and product usability.

  As general raw materials used for formulating such moisturizing cosmetics, oily raw materials such as fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anions, Polymers, UV absorbers and blocking agents, antioxidants, sequestering agents, dyes and pigments used in cationic, bilateral, nonionic surfactants, moisturizers, thickeners and film formers Examples thereof include coloring materials, fragrances, and preservatives.

  However, when such a moisturizing component is used on the skin, there is always the inconvenience of having to re-process after cleaning, only providing a temporary effect after the processing until the next cleaning.

  In general, conditioning cosmetics give skin and hair beneficial properties such as smoothness, softness, volume, calmness, beautify skin and hair, increase appeal, change appearance, or hair It is intended to be applied to the body, spread, or otherwise used in a similar manner to keep the skin healthy. In addition, quasi-drugs, even if they act on the human body, have a purpose of use that affects the structure and function of the body, and does not use it for the treatment or prevention of diseases. It is defined as not.

  Conditioning products typically include basic conditioning cosmetics for hair and skin conditioning, protection, base, points, nail makeup conditioning products and body conditioning products for cleaning, suncare, tanning, etc. It is out.

  A conditioner is used as a conditioner when it is associated with the correction or prevention of certain aspects associated with surface damage that a product is intended to improve, especially when the quality of the surface to which a substance is applied is improved. Considered.

  Taking hair as an example, hair conditioning requires a continuous management process. Hair is basically a dead cell derived from a small number of living cells that are deeply present on the surface of the skin. Thus, the hair conditioning component has no effect on substantial cell growth and cannot affect underlying cell repair. Therefore, hair conditioning must be further applied if it is removed after temporarily improving the properties of the damaged hair.

  Damage to hair by physical and chemical treatment induces changes in the physical structure of the hair. Conditioning ingredients cannot provide fundamental healing of the hair, but can temporarily enhance the cosmetic value and function of the hair prior to cleansing and removing the conditioner using a detergent.

  Most hair damages such as shampoos for cosmetic purposes, drying, brushing, styling, conditioning, permanent hair care habits and chemical exposure, sunlight, air pollution, wind, seawater and chlorinated pools Caused by various environmental factors. Conditioners can improve the cosmetic value of weathered hair through various forms of mechanisms, such as reducing static electricity, improving hair strength, protecting from ultraviolet radiation, and increasing gloss.

  Hair conditioning can alleviate hair damage by reducing hair breakage and porosity and increasing strength and gloss. Cationic polymer conditioners are very efficient conditioning components because they have an affinity that directly participates in electrical interactions between opposing charges between the polymer and the hair surface. Conditioners generally remain on the surface of the hair streaks to reduce the frictional force and skipping phenomenon against brushing, and in some other systems, volume enhancement, curl maintenance, hair richness, ease of care, etc. Is granted.

  Recent conditioners provide ease of brushing on wet and dry hair, complement and rearrange hair damaged areas to provide softness, minimize porosity, give head gloss and silky It has been devised to provide one or more of the following: providing a sensation of touch, providing protection against heat and mechanical damage, moisturizing, adding volume and thickness, and removing static electricity.

  In general, a human hair cuticle is composed of flatly superimposed cells (scales). The cuticle cells are attached like a roof tile from the root side to the end side of the hair fiber. Each cuticle layer has a thickness of about 0.3 to 0.5 μm, and the portion of the cuticle that can be seen is about 5 to 10 μm. The cuticle of human hair is generally stacked with 5 to 10 layers. Each cuticle cell of hair has various auxiliary lamella layers such as epicuticle, A-layer, exocuticle, endocuticle and inner layer. And a cell membrane complex. The outermost epicuticle layer is covered with a covalently bonded lipid (fatty acid), and the most abundant component is 18-methyleicosanoic acid (18-MEA). . This layer constitutes the outer layer of the cell membrane complex, which serves for lubrication, friction reduction, hydrophobic surface formation, and the like.

  The portion of the hair that protrudes outside the scalp is called the hair shaft, and this portion varies depending on the life and length of the hair. In addition, when hair is cut, shampoo, hair dryer, brushing, perm, hair color, etc. are used, it varies depending on environmental stress such as drying, ultraviolet rays, seawater, pool lime. In particular, the cuticle surrounding the outside of the hair shaft is damaged when it is accumulated in a complex manner, even if it is not directly affected by such stress. Injured hair has an extended end of the cuticle or is partly peeled off and further shed. Such hair loses its gloss and is not smooth due to the diffuse reflection of light. As hair damage progresses more, the layer of hair cuticles will fall off completely, exposing the fur inside, and eventually the hair will break or break easily.

  Thus, various treatments have been attempted to improve the surface of damaged hair with 18-MEA, and in particular, hair conditioning such as hair nail polish and hair essence using silicone to coat the hair surface. Products that provide skin care products are sold or are being treated through a beauty salon, and many products that give conditioning effects to the skin or hair have recently been commercialized.

  However, when such conditioning ingredients are used on the hair and skin, there is always the inconvenience of providing a temporary and short-term effect until the next wash after treatment and having to be reprocessed after washing. Existing.

  In general, UV blocking means protecting human skin, hair, fibers or the like from UV rays exposed in daily life, and preventing harmful effects and damages caused by UV rays.

  Ultraviolet rays usually radiate radio waves of 100 to 400 nm, and usually from the short wavelength side to vacuum ultraviolet rays (100 to 190 nm), UVC (190 to 280 nm), UVB (280 to 320 nm), UVA (320 to 400 nm) being classified. Among them, of the ultraviolet rays contained in sunlight, the ultraviolet rays that come into contact with the ground surface are the long wavelength portion of UVB and UVA, but the skin constituting the outermost layer of the human body can be damaged by ultraviolet rays. UVB, which is a short wavelength, is absorbed and scattered in the epidermis, but is highly damaging to living organisms, causing many acute injuries in the epidermis. Compared with this, UVA, which has a long wavelength, has low damage to living organisms, and thus, its involvement in skin injury has not been regarded as important. However, the influence of UVA contained in sunlight cannot be overlooked. Also, since UVA penetrates into the skin and reaches the lower layer of the dermis, it should be considered that the direct influence of ultraviolet rays on the dermis layer is related to chronic ultraviolet damage called photoaging. It is.

  If UVA and UVB are compared with each other, a large amount of UVA reaches the surface of the earth, but the intensity of ultraviolet rays is weak and penetrates into the epidermis and dermis layers. It is known to cause skin aging (wrinkles) by destroying skin elasticity components such as elastin. Although UVB has a relatively low surface reach compared to UVA, the intensity of ultraviolet rays is low. Strong, mostly scattered and reflected by the epidermis, but induces erythema and inflammation, causing abnormal keratinization of the skin.

  In general, the UV blocking effect is indicated by SPF (Sun Protection Factor), SPF = MED of skin coated with UV blocking agent / MDE of skin not coated with UV blocking agent; MDE (Minimal Erythma Does- It means the minimum amount of UV light (time) required to cause erythema. However, the time when erythema appears after exposure to ultraviolet rays varies depending on the weather, race, and people. In Korea, MED is known to be about 10 to 30 minutes in summer. SPF indicates a degree to prevent the occurrence of erythema due to ultraviolet rays, and mainly means a UVB blocking effect. This means that when a product with a high SPF is applied and exposed to sunlight, UVA, which has a relatively strong effect on skin blackening and aging, may be exposed unprotected. Therefore, it is important to make a product that can effectively block not only high SPF but also UVA. The blocking effect of UVA is expressed as PA +, PA ++, PA ++, which is calculated by the following formula.

  PFA = MPPD for skin with UV-blocker product / MPPD for skin without UV-blocker product, where MPPD (Minimum Persistent Pigment Darkening Does) is the minimum sustained type of immediate required to cause blackening The amount of blackening (time). This is different from SPF, and is difficult to indicate with specific numerical values. Therefore, “PFA 2 to less than 4 (PA +)-UVA blocking effect, PFA 4 to less than 8 (PA ++) — UVA blocking effect is very high, PFA8 “(PA ++++)-UVA blocking effect is very high”, it is defined that the display is divided into a certain range.

  Skin damage from UV rays is classified into acute injury such as sunburn cell, erythema, blackening (immediate blackening, delayed blackening), immunosuppression, and chronic injury such as photoaging and skin cancer. it can.

  In general, an ultraviolet blocking agent is a compound having a double bond in a molecule, and when it receives ultraviolet rays, the energy level of electrons in the molecule rises, becomes an excited state, and absorbs ultraviolet rays. -Oxidation, which is a material that prevents ultraviolet rays from coming into direct contact with the skin by physically scattering ultraviolet rays with ultraviolet absorbers such as aminobenzoic acid derivatives, cinnamic acid derivatives, salicylic acid derivatives, benzophenone derivatives, etc. UV scattering agents such as titanium and zinc oxide, cellulose-based, PVP / alpha-olefin-based polymers, acrylic acid polymers, silicone resins, fluorine-modified silicone resins, and other polymer coatings used for the purpose of increasing water resistance Can be divided into forming agents.

  Common raw materials used to formulate such UV-blocking cosmetics include oily materials such as oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, anions, etc. , Cationic, bilateral, nonionic surfactants, UV blockers, thickeners and polymeric compounds used as film formers, UV absorbers and blockers, antioxidants, sequestering agents, dyes and Color materials containing pigments, fragrances, preservatives and the like can be mentioned.

  In addition to the ingredients mentioned above, the active ingredients that actually act on the ultraviolet blocking function include cinnamic acid, glyceryl PABA, drometrizole, digalloyl trioleate, 3, (4-methylbenzylidene) camphor, menthylan. Tranilate, benzophenone-3, benzophenone-4, benzophenone-8, butylmethoxybenzoylmethane, synoxate, adenine riboside, octocrylene, octyldimethyl PABA, octylmethoxycinnamate, octylsalicylate, octyltriazone, paraaminobenzoic acid, 2- Benzimidazole-5-sulfonic acid, homosalate, zinc oxide, titanium dioxide, isoamyl-p-methoxycinnamate, bisethylhexyloxyphenol methoxyphenyl tria , Disodium phenyl dibenzimidazole tetrasulfonate, amodi-drometrizole trisiloxane, diethylhexylbutamide triazone, polysilicone-15 (dimethicodiethylbenzal malonate), methylenebis-benzotriazolyltetramethylbutylphenol , Terephthalidene dicamphor sulfonic acid and salts thereof, and the like.

  However, the use of such UV-blocking ingredients on skin, hair or fibers only provides a temporary effect after treatment until the next wash and must be reprocessed after washing or washing. Is always present.

  In general, a wound is a bruise in which the capillary of the subcutaneous tissue is damaged due to external force due to a state in which the continuity of the normal structure of the body tissue is destroyed by external force, an abrasion caused by a sharp external force, Stab wounds that are wounds contaminated with ice pieces, nails, tree branches, etc., swords, glass fragments and cuts that are wounds caused by surgery, wounds that are wounds that break the skin due to dull external force, or the skin is pulled, It can be classified as a wound that is a wound caused by dripping.

  The methods used to increase the healing effect of the wound include the method of healing the wound by covering the wound with an initial dry treatment method and maintaining it dry, and the disadvantages of existing dry therapeutic agents, the wound Non-adhesive gauze, non-adhesive gauze, non-adhesive absorbent pad, and the like, which are methods for eliminating surface and adhesiveness and not damaging epithelialization. Typical therapeutic agents useful for the treatment of chronic intractable skin ulcers such as bedsores as a wet treatment method include films, filled beads, hydrocolloids, alginate, polyurethane foam, hydrogel and the like. The drug delivery system that has been widely used recently is an effective method for the treatment of chronic wounds that are difficult to heal, and the growth factor regulates the wound healing process and enables effective wound treatment. Examples of typical bioconjugation components include growth factors, physiologically active substances, necrotic tissue removal agents, antibacterial coating agents, and the like.

  The purpose of the composition for bioconjugation for the treatment of a skin damage site such as a wound is to treat the wound site effectively and promptly while leaving the wound in an original state. It is used for the purpose of beautifying the skin and increasing its attractiveness.

Moreover, the composition for biological joining can be used also as a use for joining the crack of hair.
A composition for biobonding capable of bonding between skin and hair is generally a composition or base having a function capable of bonding between skin and hair for basic, cleansing, ordering, and basic for caring for the skin. It contains a functional composition capable of bonding between skin or hair such as products. The functional composition capable of bonding between skin or hair for the scalp is first capable of bonding between skin or hair for scalp, such as washing, treatment, hair styling, hair nourishing, hair growth treatment, etc. Functional compositions can also be included.

  Examples of general raw materials used to form such a functional composition capable of bonding between skin and hair include oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, ester oils, silicone oils, etc. Oily raw materials such as, anionic, cationic, bilateral, nonionic surfactants, moisturizers, polymer compounds used in thickeners and film forming agents, UV absorbers and blocking agents, antioxidants, It contains sequestering agents, coloring materials including dyes and pigments, fragrances, preservatives and the like.

  However, in the case of using only the composition material for bioconjugation capable of joining between the skin or hair and the drug component on the skin or hair, it only provides a temporary effect until the next washing after the treatment. However, there is always the inconvenience of having to reprocess after washing and the limit of sustained effect.

Patent Document 1 relates to a non-aqueous personal care product for skin or hair, which is a functional group capable of covalently bonding to a protein residue on the surface of hair or skin on a non-aqueous part, and includes carbonate, aldehyde (Aldehyde), propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, epoxide, epoxide, epoxide (Succinimid), hydroxysuccinimidyl ester (hydrox) succinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethylenethiomine, ethylenemine a functional group represented by acrylonitrile, acrylic acid or methacrylate ester, disulfide, ketone, and RX (R is alkyl, aryl, aralkyl, ring and unsaturated ring) Select from the group X is a conditioning component having any one or more selected from the group consisting of I, Br, or Cl, and is separated into a non-aqueous part and an aqueous part A hair or skin personal care product characterized by being mixed and used immediately before use, but the various functional groups presented above are harmful to the human body, or Whether the content of the amino acids of the protein constituting the hair or skin targets lysine containing a small amount of hair (1.9 to 3.1%) and skin keratin (3.1 to 6.9%) Since cysteine is targeted and reacted in the hair (16.6-18%) and skin keratin (2.3-3.8%), the reaction efficiency decreases, and each substance is synthesized individually. There is a problem you have to

Korean Patent Publication No. 2008-0064467

  An object of the present invention is to provide a dye composition capable of continuously imparting a semi-permanent dyeing effect to hair, skin, fibers or skin without damage.

  Another object of the present invention is to provide a moisturizing cosmetic composition that can continuously provide a semi-permanent moisturizing effect without damaging the hair or skin.

  Yet another object of the present invention is to provide a conditioning cosmetic composition that can continuously impart a semi-permanent conditioning effect to hair or skin without damage.

  Another object of the present invention is to provide an ultraviolet blocking composition capable of continuously imparting a semi-permanent ultraviolet blocking effect without damaging hair, skin or fibers.

  Still another object of the present invention is to provide a composition for bioconjugation that can continuously impart a semipermanent bioconjugation effect to hair or skin without damage.

  As means for solving the above problems, the present invention provides a staining composition comprising a carbodiimide compound and a dye.

  As another means for solving the above problems, the present invention provides a moisturizing cosmetic composition comprising a carbodiimide compound and a moisturizing component.

  As yet another means for solving the above-mentioned problems, the present invention provides a conditioning cosmetic composition comprising a carbodiimide compound and a conditioning component.

  As yet another means for solving the above-mentioned problems, the present invention provides an ultraviolet blocking composition comprising a carbodiimide compound and an ultraviolet blocking component.

  As yet another means for solving the above-mentioned problems, the present invention provides a bioconjugate composition comprising a carbodiimide compound and a bioconjugate component.

  The dye composition according to the present invention contains a reactive dye and / or a carbodiimide-based compound into which a specific functional group capable of covalent bonding with a protein residue of hair, skin, fiber or skin is contained, It forms a covalent bond without damage to the skin, fibers or skin and provides the desired hue semi-permanently.

  The cosmetic composition for moisturizing according to the present invention contains a reactive moisturizing component and / or a carbodiimide-based compound into which a specific functional group capable of covalent bonding with a protein residue of hair or skin is contained. It forms a covalent bond without damage and provides a semi-permanent moisturizing effect.

  The conditioning cosmetic composition according to the present invention contains a reactive conditioning component and / or a carbodiimide-based compound into which a specific functional group capable of covalent bonding with a protein residue of hair or skin is contained, and is applied to the hair or skin. Forms a covalent bond without damage and provides a conditioning effect semipermanently.

  The ultraviolet blocking composition according to the present invention contains a reactive ultraviolet blocking component and / or a carbodiimide-based compound into which a specific functional group capable of covalent bonding with a protein residue of hair, skin or fiber is contained. Forms covalent bonds without damaging the skin or fibers, providing a semi-permanent UV blocking effect.

  The composition for bioconjugation according to the present invention contains a reactive bioconjugate component and / or a carbodiimide-based compound into which a specific functional group capable of covalent bonding with a protein residue of hair or skin is contained. It forms a covalent bond without damage and provides a biomating effect semi-permanently.

It is a photograph which shows the dyeing | staining state of the yak hair with respect to the comparative example 1 and Example 1 after 10 times shampooing. It is a photograph which shows the dyeing | staining state of the wool cloth with respect to Example 4 and 5 after 1 time shampooing and 10 times after shampooing. It is a photograph which shows the hair state before and after processing the composition for biological joining by Example 42 of this invention to hair.

The present invention relates to a staining composition comprising a carbodiimide compound and a dye.
The dye composition according to the present invention is, for example, made by reacting a carbodiimide compound with an existing known dye and covalently binding to hair, skin, fiber, or skin protein via a reactive dye having a carbodiimide group bonded thereto. By forming the dye, the dye activity can be maximized.

  The carbodiimide compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire composition. If the content is less than 0.001 part by weight, there is a problem that a continuous dyeing effect is difficult to appear, and if it exceeds 10 parts by weight, a carbodiimide compound that is excessively present above the reaction position existing in the skin is By reacting with the active substance in a non-reactive state, there is a problem that it can act as a lost component without helping to improve sustainability.

The dyes used in the present invention were selected as the chromophore _{NO 2, N = N, C} = O, C = C, C = N, C = S, from the group consisting of N = O and N = NO 1 It can contain more than one group, but is not limited to this. Further, the dye, -OCH _{3, -N} as Choirodan _{(CH 3) 2, -NH (} CH 3), - NO 2, -CF 3, -OH, -OCH 3, -Cl and -NH ₂ One or more atomic groups selected from the group consisting of, but not limited to, can be included. The dye may be one or more reactive groups selected from the group consisting of —COONa, —COOK, —COOH, —NH ₂ , —NHR, —NR ₂ , —Cl, —Br, —I and —F. However, it is not limited to this. In addition, the dye may be a natural dye or a synthetic dye used for hair, skin, fiber, skin, etc., and the natural dye may be purpurin, mungistin, melanin or melanin precursor. The synthetic dye may be, but is not limited to, Red No. 3, Red No. 104, Red No. 105, Red No. 201, Red No. 202, Red No. 220, Red No. 230, Red No. 231. Red 232, Red 401, Red 405, Yellow 4, Yellow 202, Orange 207, Red 106, Red 213, Red 214, Red 215, Yellow 404, Yellow 405, Blue 403, Disperse Blue 1 (Disperse Blue 1), Disperse Violet 1 (Disperse Vio) et 1), Disperse Orange 3 (Disperse Orange 3), Disperse Black 9 (Disperse Black 9), HC Blue 2 (HC Blue 2), HC Red 3 (HC Red 3), HC Yellow 5 (HC) Yellow 5) or HCI Red 1 (HC Red 1), but is not limited thereto.

  The dye is preferably used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight or 0.1 to 5 parts by weight with respect to 100 parts by weight of the total composition. . If the content is less than 0.001 parts by weight, there is a problem of effective performance limit, and if it exceeds 50 parts by weight, there is a problem in dosage form and dosage form stabilization.

  In particular, the dye of the present invention can increase the reaction efficiency with a carbodiimide compound by including a carboxyl group or an amine group in the molecule.

  In the present invention, the dye may have a functional group covalently bonded to a protein residue on the surface of hair, skin, fiber, or skin.

  Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le, can be at least one selected from the group consisting of disulfide and ketone, but are not limited thereto.

  In addition, the protein may include reactive residues such as thiol, hydroxyl, carboxyl, or amine.

  The carbodiimide-based compound is a generic term for compounds having a structure represented by the following chemical formula 1 in the molecule.

[Chemical Formula 1]
-N = C = N-

  The carbodiimide-based compound preferably includes at least about 1 to 1000 structures of the chemical formula 1, more preferably 1 to 100 structures represented by the chemical formula 1 in the molecule. More preferably, 1 to 10 structures represented by the formula are included in the molecule.

  In this case, if the number of carbodiimide groups represented by Chemical Formula 1 exceeds 1000 in one molecule, the viscosity of the raw material is very large, the molecular weight is very large, and the reaction positions that can be reacted are extremely excessive. The molecule having a carbodiimide group becomes very large, and a problem that the efficiency is lowered occurs by blocking a portion showing a functional effect of a molecule having a substantial function.

  In the present invention, specific examples of the carbodiimide-based compound can be a compound represented by the following chemical formula 2, wherein n is 4 and m is 11, 3, -bis (1-isocyanate-1-methylethyl)-, homopolymer, polyethylene glycol mono-ether-blocked (Benzene, 1, 3-bis (1-isocyanato-1-methylethyl)-, homopolymer, Polyethylene glycol mono-Me-ether-blocked) (hereinafter referred to as a polymer form carbodiimide compound).

  In the chemical formula 2, n is 1 to 100 and m is 1 to 100.

  In the present invention, another example of the carbodiimide compound is a compound represented by the following chemical formula 3, which is 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) can be used.

  As a preferred embodiment of the dye composition according to the present invention, a dye having a carboxyl group is directly made into a reactive ester dye form having bioreactivity, or hair (17.5 to 21.9%), skin keratin (15.5 to 23.5%) or a carbodiimide system in which an amino acid (for example, aspartic acid or glutamic acid) present in an excessive amount in a fiber (19 to 23%) can be reactively esterified to target a dye containing an amine group By using the compound to make a reactive ester form (reactive dye) to increase the reaction efficiency, the effect can be reliably increased. Other functionalities such as carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide that can target other amino acids. The effect can be further increased by using dyes containing groups in the molecule.

  As a more preferred embodiment, a carbodiimide compound or a 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride in a polymer form of Formula 2 is first applied to the surface of a dye molecule having a carboxyl group or the protein of skin or hair. A carbodiimide-type compound such as (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) undergoes a primary reaction to form a reactive ester, and the reactive ester functional group thus formed further has an amine in the molecule. An excellent dyeing effect can be obtained under mild and mild conditions on the human body by reacting the dye or reacting with an amine on the surface of hair, skin, fibers or skin. At the time of the reaction, the reaction is preferably possible under the conditions of pH 2 to 10, more preferably, the reaction is preferably performed at pH 3 to 9, and most preferably the reaction is performed on an acidic or weakly acidic aqueous solution having a pH of about 4 to 5. Doing so can most increase the reaction efficiency. The reaction is completed within 1 to 30 minutes.

  In the following reaction formula 1, a dye molecule having a carboxyl group undergoes a primary reaction with a carbodiimide compound to form a reactive ester, and subsequently reacts with a biological amino acid having an amine residue to form a covalent bond. Indicates.

  In the following reaction formula 2, aspartic acid and glutamic acid, which are biological amino acids having a carboxyl group on the hair protein surface, undergo a primary reaction with a carbodiimide compound to form a reactive ester, and subsequently react with a dye having an amine residue. Shows a schematic diagram of a reaction for forming a covalent bond.

  Carbodiimide compounds increase the reaction efficiency of hair proteins and dyes, and reactive dyes bound to hair are less likely to be removed during general washing with shampoos, detergents, soaps, etc. The attached state can be maintained.

  The reaction formula is applicable to skin, fibers, skin, etc. in addition to hair as a typical example of hair.

  The present invention also includes a carbodiimide group, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde, Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile, Acrylic acid or methacrylic acid ester, disulfide It may include reactive dyes which functional groups are bonded to form covalent bonds with one or more proteins selected from the De and the group consisting of ketones.

  For example, as shown in Reaction Formula 1, a dye (reactive dye) to which a carbodiimide group generated by a primary reaction of a carbodiimide compound is bonded can be included.

Moreover, this invention can contain the dyeing | staining composition containing the said reactive dye.
In order to increase the effect incidentally in the staining composition according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear and branched long-chain alkyl quaternary ammonium salts, etc. Formulation can be facilitated when used in combination with other cationic surfactants, cationic cellulose, cationic guar, cationic polymers such as cationic polyvinyl pyrrolidone, silicone and the like. Also, for formulation, solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH regulators, sequestering agents, colorants, pearling agents, appearance improvers, pigments Ingredients for formulation such as powder particles can be incidentally included. The component for the formulation can be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the entire composition.

  The dye composition according to the present invention contains a dye component having a functional group, and can be used for formulating all hair and skin dye compositions. Examples of dye compositions include pre-shampoo compositions, shampoos, rinse treatments, waxes, sprays, hair mousses, hair lotions, essences, hair creams, permanent hair dyes, temporary hair dyes, permanent agents. It can contain all cosmetic preparations that can be used on the hair and human body, such as non-woven fabrics and sheets, and can also contain all preparations in the skin. In the case of textile products, preparations such as fiber dyes can be included.

  More preferably, the staining composition according to the present invention contains a carbodiimide-based compound and a dye having a reactive functional group at the same time, and when the preparation is reduced in activity in an aqueous system, the dye composition in a non-aqueous dosage form is used. It is easier to maintain the activity, and the reaction may be carried out by mixing with a buffer for pH adjustment just before use, or by contacting with water in the washing process. Examples of non-aqueous dosage forms include liquid types, sheet types, powder powder types, tablet types, oils, waxes, ampoules, gels and the like used as ordinary non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the dye can be formulated into a single agent in an encapsulated form or two agents in a separated form. In addition, a method in which a derivative in a form in which a functional group having reactivity and a component having a dye function are combined through encapsulation is shielded from moisture is also used.

  In order to increase the effect of dyes having functional groups in the dye composition according to the present invention, 2-basic acid ester oils such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, polyols, polyethylene glycol, propylene glycol Hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The above-mentioned solvents are used as solvents for hardly soluble substances by increasing the permeability of hair, skin, fibers or skin. More preferably, the solvent used to increase the active fat effect of the dye having a functional group includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

The present invention relates to a moisturizing cosmetic composition comprising a carbodiimide compound and a moisturizing component.
The moisturizing cosmetic composition according to the present invention is, for example, made by reacting a carbodiimide compound with a known moisturizing component and covalently binding to hair or skin protein through a reactive moisturizing component to which a carbodiimide group is bonded. By forming, the moisturizing effect can be maximized.

  The carbodiimide-based compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire cosmetic composition. If the content is less than 0.001 part by weight, there is a problem that a continuous moisturizing effect is difficult to appear, and if it exceeds 10 parts by weight, a carbodiimide compound that is excessively present above the reaction position present in the skin is There is a problem that by reacting with an effective substance in a non-reactive state, it can act as a lost component without helping to improve sustainability.

  In the present invention, “moisturizing effect” means a function of preventing damage such as cracking and roughening by maintaining normal moisture in human skin, hair, etc., and making it appear soft and vibrant. To do.

Moisturizing ingredients used in the present invention include moisturizing ingredients that can fill damaged sites of skin or hair such as extracts from natural products such as animals, plants, minerals, amino acids, peptides, proteins, sugars, vitamins, etc. You can, but you are not limited to this. For example, glycerin, propylene glycol, butylene glycol, dipropylene glycol, capryl glycol, diglycerin, methyl glutes, ethoxydiglycol, glyceres, propanediol, diethoxydiglycol pyrrolidone carboxylic acid, sodium lactate, sodium PCA, mineral oil, petroleum jelly Lanolin, jojoba oil, olive oil, glycosphingolipid, phospholipid, lipid mixture, isononyl isononanoate, betaine, carboxymethylchitin, ceramide, glucosylceramide, glucose aminoglucan, alpha-glucan, hyaluronic acid, hydrolyzed Hyaluronic acid, betaine, chitosan, chitosan succinamide, vitamin E (tocopherol), urea, hydroxyethyl Urea, glucosides, gamma PGA, xylityl glucoside, xylitol, pentaerythrityl tetraisostearate, sodium chondroitin sulfate, chondroitin-4-sulfate, atelocollagen, beta glucan, PEG, pyridoxine tris-hexyldecanoate, potassium PCA Sodium polygamma-glutamate, polyglutamic acid, glyceryl polyacrylate, galactoarabinan, polyglycerin-3 crosspolymer, sodium hyaluronate, bis-PEG-18 methyl ether dimethylsilane, bis-ethoxydiglycol succinate, Lecithin, ascovir tetraisopalmitate, glycosyl trehalos, hydrolyzed starch hydrol sate (Hydrogenated) touch Hydrolysate), 1,2-hexanediol, mannitol, arginine, serine, sucrose, PCA, citrulline, glycogen, histidine HCL, alanine, threonine, glutamic acid, lysine HCL, phosphate buffered saline, creatine , Cholesteryl isostearate, cholesteryl chloride, cholesteryl nonanoate, BHT, sodium dilauramide glutamic lysine, maltodextrin, polyquaternium-39, cholecalciferol PEG-12 ether, saccharide ismaleate, sorbitol and these It may be one or more selected from the group consisting of derivatives.

  The moisturizing component is used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire cosmetic composition. It is preferable. If the content is less than 0.001 parts by weight, there is a problem of effective performance limit, and if it exceeds 50 parts by weight, there is a problem in dosage form and dosage form stabilization.

  In particular, in the present invention, the moisturizing component can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.

  In the present invention, the moisturizing component may have a functional group that covalently binds to a protein residue on the surface of hair or skin.

  Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le, can be at least one selected from the group consisting of disulfide and ketone, but are not limited thereto.

  In addition, the protein may include reactive residues such as thiol, hydroxyl, carboxyl, or amine.

  The carbodiimide-based compound is a generic term for compounds having a structure represented by the following chemical formula 1 in the molecule.

[Chemical Formula 1]
-N = C = N-

  The carbodiimide-based compound preferably includes at least about 1 to 1000 structures of the chemical formula 1, more preferably 1 to 100 structures represented by the chemical formula 1 in the molecule. More preferably, 1 to 10 structures represented by the formula are included in the molecule.

  In this case, if the number of carbodiimide groups represented by Chemical Formula 1 exceeds 1000 in one molecule, the viscosity of the raw material is very large, the molecular weight is extremely large, and the reaction positions where reaction can be performed are extremely excessive. Thus, a molecule having a carbodiimide group becomes very large, and a portion that exhibits a functional effect of a molecule having a substantial function is shielded, thereby causing a problem that efficiency is lowered.

  In the present invention, specific examples of the carbodiimide-based compound can be a compound represented by the following chemical formula 2, wherein n is 4 and m is 11, 3, -bis (1-isocyanate-1-methylethyl)-, homopolymer, polyethylene glycol mono-ether-blocked (Benzene, 1, 3-bis (1-isocyanato-1-methylethyl)-, homopolymer, Polyethylene glycol mono-Me-ether-blocked) (hereinafter referred to as a polymer form carbodiimide compound).

  In the chemical formula 2, n is 1 to 100 and m is 1 to 100.

  As another example of the carbodiimide compound in the present invention, as a compound represented by the following chemical formula 3, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) Alternatively, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) can be used.

  As a preferred embodiment of the moisturizing cosmetic composition according to the present invention, a moisturizing component having a carboxyl group is directly made into a reactive ester moisturizing component form having bioreactivity or hair (17.5 to 21.9%). And carbodiimide compounds that can target the moisturizing components containing amine groups by reactive esterification of amino acids (eg, aspartic acid, glutamic acid) present in excess in skin keratin (15.5-23.5%) The effect can be reliably increased by making the reactive ester form (reactive moisturizing component) and increasing the reaction efficiency. Other functionalities such as carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide that can target other amino acids. A moisturizing component containing a group in the molecule can be used to further increase the effect.

  As a more preferable embodiment, a carbodiimide compound or a 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide in a polymer form of Formula 2 is first applied to the surface of a moisturizing component molecule having a carboxyl group or the protein of skin or hair. A carbodiimide-type compound such as hydrochloric acid (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) undergoes a primary reaction to form a reactive ester, and an amine is further added to the formed reactive ester functional group in the molecule. An excellent moisturizing effect can be obtained by reacting the moisturizing component or reacting with an amine on the surface of hair or skin. At the time of the reaction, the reaction is preferably possible under the conditions of pH 2 to 10, more preferably, the reaction is preferably performed at pH 3 to 9, and most preferably the reaction is performed on an acidic or weakly acidic aqueous solution having a pH of about 4 to 5. Doing so can increase the reaction efficiency most. The reaction is completed within 1 to 30 minutes.

  In the following reaction formula 3, a moisturizing component molecule having a carboxyl group undergoes a primary reaction with a carbodiimide compound to form a reactive ester, and subsequently reacts with a biological amino acid having an amine residue to form a covalent bond. The figure is shown.

  A moisturizing component having a reactive ester by first reacting aspartic acid and glutamic acid, which are biological amino acids having a carboxyl group on the protein surface of hair or skin, with a carbodiimide compound in the following reaction formula 4 to form a reactive ester The reaction schematic diagram which reacts with and forms a covalent bond is shown.

  Reactive moisturizing ingredients that bind to hair or skin by increasing the reaction efficiency of hair or skin proteins and moisturizing ingredients with carbodiimide compounds are less likely to be removed during general washing with shampoos and soaps, and are almost permanent. It can maintain the state of being attached to the hair or skin.

  The present invention also includes a carbodiimide group, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylic acid ester, dis It may include reactive moisturizing which functional groups are bonded to form covalent bonds with one or more proteins selected from Fido the group consisting of ketones.

  For example, a moisturizing component to which a carbodiimide group generated by a primary reaction of a carbodiimide compound as shown in the reaction formula 1 is bonded can be included. Moreover, this invention can contain the cosmetic composition for moisturizing containing the said reactive moisturizing component.

  In the cosmetic composition for moisturizing according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear and branched long-chain alkyl quaternary ammoniums are added to increase the effect incidentally. When mixed with a cationic surfactant such as a salt, a cationic polymer such as cationic cellulose, cationic guar or cationic polyvinyl pyrrolidone, silicone or the like, formulation can be facilitated. In addition, for formulation into cosmetic preparations, solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH regulators, sequestering agents, colorants, pearling agents, appearance Ingredients for formulating cosmetic preparations such as improvers, pigments and powder particles can be incidentally included. The component for the formulation can be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the entire composition.

  The moisturizing cosmetic composition according to the present invention contains a component having a moisturizing function having a functional group, and is used for the formulation of the moisturizing cosmetic composition. Examples of application of skin products are generally basic skin care (protection lotion, serum, essence, lotion, cream, etc.) and color cosmetics (makeup base, foundation, powder, eye shadow, lip glaze). , Lipstick, lip bum, etc.), nail makeup (manicure, nutrients, toughener, top coat, etc.), cosmetics for cleaning (foam cleansing, cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, Soap, cleansing tissue, etc.), suncare cosmetics, body cosmetics (body lotion, shower gel, body cream, body oil, etc.), and shampoo, rinse, treat Cement, it can include hair pack, hair essence, waxes, gels, all the formulations of the spray and the like.

  More preferably, the moisturizing cosmetic composition according to the present invention contains a carbodiimide-based compound and a moisturizing component having a reactive functional group at the same time. It is easier to maintain its activity, and it can be mixed with a buffer just before use to adjust the pH, or the reaction can be caused to come into contact with water during the washing process. Examples of non-aqueous dosage forms include liquid types, sheet types, powder powder types, tablet types, oils, waxes, ampoules, gels and the like used as ordinary non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the moisturizing component can be formulated into a single agent in an encapsulated form or two agents in a separated form. In addition, a method in which a derivative in a form in which a functional group having reactivity and a component having a moisturizing function are combined through encapsulation is shielded from moisture is also used.

  In order to increase the moisturizing effect having functional groups in the moisturizing cosmetic composition according to the present invention, 2-basic acid ester oils such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, polyols, polyethylene glycol, propylene Glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The mentioned solvents increase the permeability of the hair or skin and are used as solvents for poorly soluble substances. More preferably, the solvent used to increase the active fat and oil effect of the moisturizing component having a functional group includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

  The present invention relates to a conditioning cosmetic composition comprising a carbodiimide compound and a conditioning component.

  The conditioning cosmetic composition according to the present invention, for example, reacts a carbodiimide-based compound with a known conditioning component to form a covalent bond with a hair or skin protein via a reactive conditioning component to which a carbodiimide group is bonded. By forming it, the conditioning effect can be maximized.

  The carbodiimide-based compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire cosmetic composition. If the content is less than 0.001 part by weight, there is a problem that a continuous conditioning effect is difficult to appear. If the content exceeds 10 parts by weight, a carbodiimide compound that is excessively present above the reaction position present in the hair and skin reacts with the skin. There is a problem that it can act as a lost component without helping to improve the sustainability by reacting with the active substance in a state where it is not.

  In the present invention, “conditioning” means that the skin and hair are beautified, increased in attractiveness and appearance by imparting beneficial properties such as smoothness, softness, calmness, gloss, and volume to the skin and hair. It can be applied to the body, applied to the body, or the like in a similar manner to change hair or keep the hair and skin healthy. With the conditioning effect, for example, effects such as gloss and gloss, static electricity reduction, etc. can be shown.

  Conditioning ingredients used in the present invention may include conditioning active ingredients capable of filling damaged sites of skin or hair such as extracts from natural products such as animals, plants, minerals, amino acids, peptides, proteins, etc. Not limited to this. For example, it may be one or more selected from the group consisting of polymers, silicones, fatty alcohols, fatty acids, waxes, ester oils and derivatives thereof.

  Examples of the natural product-derived extract include seaweed extract, sunflower seed extract, bitter extract, ginseng extract, yellow ginseng extract, gold leaf flower extract, white flower sap, white flower extract, flower grass Extract, loofah extract, bergamot extract, flat extract, Takayama Benjing extract, camellia extract, camellia extract, red ginseng, shellfish extract, lily of the valley extract, honeycomb extract, cassis extract , Including sarcophagus extract, lemon extract, pine green extract, green tea extract, broccoli extract, honey extract, cranberry extract, berry extract, lavender extract, lentil extract, ginger water extract, etc. Examples of the protein and peptide may include protein and peptide obtained from tengu silk, silk, polylysine, seaweed, wool and hair, wheat, and the like.

  Examples of the amino acids include glycine, alanine, valine, leucine, isoleucine, threonine, serine, cysteine, cystine, methionine, aspartic acid, asparagine, glutamic acid, diiodotyrosine, lysine, arginine, histidine, phenylalanine, tyrosine, tryptophan, proline, Oxyproline and the like can be included.

In addition, the polymer may be a linear, branched chain, or network polymer compound having a molecular weight of about 1,000 to 1,000,000. It can also be used when various substituents of a bond or a ring structure are included, so that the reaction for attaching a bioreactive functional group to any one of the terminals in the molecule is facilitated. _{COONa, -COOK, -COOH, -NH 2} , -NHR, -NR 2, -Cl, -Br, -I , or to attach a biological reaction groups such as -F group, a residue having a reactive It is preferable that at least one or more be contained in the molecule. More preferably, it is a chain and branched chain polymer having about 10,000 to 500,000 carbon atoms, and the reaction for attaching a bioreactive functional group to any one of the terminals in the molecule is facilitated. _{-COONa, -COOK, -COOH, -NH 2} , -NHR, -NR 2, -Cl, -Br, -I , or to attach a biological reaction groups such as -F group, the remaining reactive with A compound containing at least one group in the molecule can be used. For example, polyamine polymer, polycarboxylic acid polymer, and methacryloylethyl betaine / methacrylate copolymer (octylacrylamide / acrylate / butylethylethyl methacrylate / octylacrylamide copolymer). Bilateral polymers such as polyvinylpyrrolidone, PVP / VA copolymer (PVP / VA copolymer), PVP / dimethylaminoethyl methacrylate copolymer (PVP / Dimethylamine) nonionic polymers such as hydrate methacrylate copolymers, and acrylate methacrylate copolymers (VA / Crotonates / Vinyl neodecanoate copolymers), such as VA / crotonates / vinyl neodecanoate anionic copolymers. It can be a polymer or the like, but is not limited thereto.

  Examples of the silicones include dimethicone, trimethicone, phenyltrimethicone, amodimethicone, amodiphenyltrimethicone, amodi-pentaphenyltrimethicone, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methyltrimethicone, The compound may be, but is not limited to, phenyltrimethicone, methicone, cyclomethicone, alkylmethylsiloxane, dimethicone copolyol, and trimethylsilylamodimethicone.

  The fatty alcohols are chain and branched fatty alcohol compounds having about 10 to 50 carbon atoms, such as lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, etc. Not.

  The fatty acids are preferably, for example, 18-methyleicosanoic acid, lauric acid, stearic acid, isostearic acid and the like as the chain and branched fatty acid compounds having about 10 to 50 carbon atoms, but are not limited thereto.

  Examples of the waxes include, but are not limited to, candelilla wax, carnauba wax, rice wax, bees wax, lanolin, ozokerite, ceresin wax, paraffin wax, microcrystalline wax, and polyethylene wax. .

  The ester oil is, for example, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate isopropyl linoleate, decyl myristate, cetyl myristate, cetyl palmitate, hydrogenated polyisobutene, etc. However, it is not limited to this.

  The conditioning component may be used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the total cosmetic composition. Is preferred. If the content is less than 0.001 part by weight, there is a limit to the provision of the effect by the active ingredient. There is a problem of acting as a lost component.

  In particular, the conditioning component of the present invention can increase the reaction efficiency with a carbodiimide compound by including a carboxyl group or an amine group in the molecule.

  In the present invention, the conditioning component may have a functional group that covalently binds to a protein residue on the surface of hair or skin.

  Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le, can be at least one selected from the group consisting of disulfide and ketone, but are not limited thereto.

  In addition, the protein may include reactive residues such as thiol, hydroxyl, carboxyl, or amine.

  The carbodiimide-based compound is a generic term for compounds having a structure represented by the following chemical formula 1 in the molecule.

[Chemical Formula 1]
-N = C = N-

  The carbodiimide-based compound preferably includes at least about 1 to 1000 structures of the chemical formula 1, more preferably 1 to 100 structures represented by the chemical formula 1 in the molecule. More preferably, 1 to 10 structures represented by the formula are included in the molecule.

  In this case, when the number of carbodiimide groups represented by Chemical Formula 1 exceeds 1000 in one molecule, the viscosity of the raw material is very large, the molecular weight is extremely large, and the reaction positions where the reaction can be performed are extremely excessive. As a result, a molecule having a carbodiimide group becomes very large, and a portion that exhibits a functional effect of a molecule having a substantial function is blocked.

  In the present invention, specific examples of the carbodiimide-based compound can be a compound represented by the following chemical formula 2, wherein n is 4 and m is 11, 3, -bis (1-isocyanate-1-methylethyl)-, homopolymer, polyethylene glycol mono-ether-blocked (Benzene, 1, 3-bis (1-isocyanato-1-methylethyl)-, homopolymer, Polyethylene glycol mono-Me-ether-blocked) (hereinafter referred to as a polymer form carbodiimide-based compound of Formula 2).

  In the chemical formula 2, n is 1 to 100 and m is 1 to 100.

  As another example of the carbodiimide compound in the present invention, as a compound represented by the following chemical formula 3, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) Alternatively, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) can be used.

  As a preferred embodiment of the conditioning cosmetic composition according to the present invention, a conditioning component having a carboxyl group is directly made into a reactive ester conditioning component form having bioreactivity, or hair (17.5 to 21.9%) and Reactive esterification of amino acids (eg, aspartic acid, glutamic acid) present in excess in skin keratin (15.5-23.5%), and using carbodiimide-based compounds that can be targeted by conditioning components containing amine groups By creating a reactive ester form (reactive conditioning component) to increase the reaction efficiency, the effect can be reliably increased. Other functionalities such as carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide that can target other amino acids. Conditioning components that contain groups in the molecule can be used to further increase the effect.

  As a more preferred embodiment, a carbodiimide compound or a 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide in a polymer form of Formula 2 is first applied to a conditioning component molecule having a carboxyl group or the surface of a protein of skin or hair. A carbodiimide-type compound such as hydrochloric acid (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) undergoes a primary reaction to form a reactive ester, and an amine is further added to the formed reactive ester functional group in the molecule. An excellent conditioning effect can be obtained by reacting the conditioning component it has or reacting with amines on the surface of the hair or skin. At the time of the reaction, the reaction is preferably possible under the conditions of pH 2 to 10, more preferably, the reaction is preferably performed at pH 3 to 9, and most preferably the reaction is performed on an acidic or weakly acidic aqueous solution having a pH of about 4 to 5. Doing so can increase the reaction efficiency most. The reaction is completed within 1 to 30 minutes.

  A reaction scheme in which a conditioning component molecule having a carboxyl group in the following reaction formula 5 undergoes a primary reaction with a carbodiimide compound to form a reactive ester, and subsequently reacts with a biological amino acid having an amine residue to form a covalent bond. The figure is shown.

  Conditioning component in which the aspartic acid and glutamic acid, which are biological amino acids having a carboxyl group on the protein surface of hair or skin, reacts first with a carbodiimide compound to form a reactive ester, and subsequently has an amine residue. The reaction schematic diagram which reacts with and forms a covalent bond is shown.

  Carbodiimide compounds increase the reaction efficiency of hair or skin proteins and conditioning ingredients, and reactive conditioning ingredients bound to hair or skin are less likely to be removed during general washing with shampoos and soaps, and are almost permanent. In particular, it can maintain a state of being attached to hair or skin.

  The present invention also includes a carbodiimide group, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde. , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylic acid Ester, may include reactive conditioning component which functional groups are bonded to form covalent bonds with one or more proteins selected from the group consisting of disulfides and ketones.

For example, as shown in the reaction formula 1, a conditioning component to which a carbodiimide group generated by a primary reaction of a carbodiimide compound is bonded can be included. In addition, the present invention may include a conditioning cosmetic composition including the reactive conditioning component.
In the conditioning cosmetic composition according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear and branched long-chain alkyl quaternary ammonium salts are added to increase the effect incidentally. When mixed with a cationic surfactant such as cationized cellulose, cationized cellulose, cationized guar, cationized polymer such as cationized polyvinyl pyrrolidone, silicone, etc., formulation can be facilitated. In addition, solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH regulators, sequestering agents, colorants, pearlizing agents, appearance improvements for formulation into cosmetic preparations Ingredients for formulating cosmetic preparations such as agents, pigments, and powder particles can be included. The component for the formulation can be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the entire composition.

  The conditioning cosmetic composition according to the present invention includes a conditioning function component having a functional group, and is used for the formulation of a conditioning cosmetic composition. Examples of application of skin products are generally basic skin care (protection lotion, serum, essence, lotion, cream, etc.) and color cosmetics (makeup base, foundation, powder, eye shadow, lip glaze). , Lipstick, lip bum, etc.), nail makeup (manicure, nutrients, toughener, top coat, etc.), cosmetics for cleaning (foam cleansing, cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, Soap, cleansing tissue, etc.), suncare cosmetics, body cosmetics (body lotion, shower gel, body cream, body oil, etc.) can all be included, and even shampoos, rinses and trees in the hair Instrument, it is possible to include hair pack, hair essence, wax, gel, all of the preparation of the spray and the like.

  More preferably, the conditioning cosmetic composition according to the present invention contains a carbodiimide-based compound and a conditioning component having a reactive functional group at the same time, and when the preparation has a reduced activity in an aqueous system, it is a non-aqueous dosage form. It is easier to maintain the activity, and it can be mixed with a buffer for pH adjustment just before use, or the reaction can be caused to come into contact with water in the washing process. Examples of non-aqueous dosage forms include liquid types, sheet types, powder powder types, tablet types, oils, waxes, ampoules, gels and the like used as ordinary non-aqueous cosmetic preparations. Further, the carbodiimide compound and the conditioning component can be formulated into a single agent in an encapsulated form or two agents in a separated form. In addition, a method of blocking a derivative in a form in which a functional group having reactivity and a component having a conditioning function are combined through encapsulation from moisture is also used.

  In order to increase the conditioning effect having functional groups in the conditioning cosmetic composition according to the present invention, 2-basic acid ester oils such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, polyols, polyethylene glycol, propylene glycol Hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The mentioned solvents increase the permeability of the hair or skin and are used as solvents for poorly soluble substances. More preferably, the solvent used to increase the active fat effect of the conditioning component having a functional group includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

The present invention relates to an ultraviolet blocking composition comprising a carbodiimide compound and an ultraviolet blocking component.
The composition for blocking UV rays according to the present invention includes, for example, a protein of hair, skin, or fiber through a reactive UV blocking component in which a carbodiimide group is bonded by reacting a known UV blocking component with a carbodiimide compound. By forming a covalent bond with each other, the ultraviolet blocking effect can be maximized.

  The carbodiimide compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire composition. If the content is less than 0.001 part by weight, there is a problem that a continuous UV-blocking effect is difficult to appear, and if it exceeds 10 parts by weight, a carbodiimide compound that is excessively present above the reaction position present on the skin is present. Alternatively, there is a problem that, by reacting with an active substance in a state of not reacting with fibers, it can act as a lost component without helping to improve sustainability.

  In the present invention, the “ultraviolet ray blocking effect” means a function of protecting skin, hair, and the like from ultraviolet rays exposed in daily life, and preventing harmful effects and damages caused by the ultraviolet rays.

  The ultraviolet blocking component used in the present invention includes ultraviolet absorbers such as p-aminobenzoic acid derivatives, cinnamic acid derivatives, salicylic acid derivatives and benzophenone derivatives, ultraviolet scattering agents such as titanium oxide and zinc oxide, cellulose-based, PVP / Alpha olefin polymers, acrylic acid polymers, silicone resins, fluorine-modified silicone resins and other resins, and polymer film forming agents can be included. Examples of components having an actual ultraviolet blocking function include, for example, cinnamic acid, glyceryl PABA, drometrizole, digalloyl trioleate, 3, (4-methylbenzylidene) camphor, menthyl anthranilate, benzophenone-3, benzophenone-4 , Benzophenone-8, butylmethoxybenzoylmethane, sinoxate, adenine riboside, octocrylene, octyldimethyl PABA, octylmethoxycinnamate, octyl salicylate, octyl triazone, paraaminobenzoic acid, 2-benzimidazole-5-sulfonic acid, homosalate, Zinc oxide, titanium dioxide, isoamyl-p-methoxycinnamate, bisethylhexyloxyphenol methoxyphenyl triazine, disodium phenyl dibenzo Dimidazole tetrasulfonate, amodi-drometrizole trisiloxane, diethylhexylbutamide triazone, polysilicone-15 (dimethicodiethyl benzal malonate), methylene bis-benzotriazolyl tetramethylbutylphenol, terephthalidene dicamphor sulfonic acid And one or more selected from the group consisting of the salts thereof.

  The ultraviolet blocking component may be used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the total composition. preferable. If the content is less than 0.001 parts by weight, there is a problem of effective performance limit, and if it exceeds 50 parts by weight, there is a problem in dosage form and dosage form stabilization.

  In particular, the ultraviolet blocking component in the present invention can increase the reaction efficiency with the carbodiimide compound by including a carboxyl group or an amine group in the molecule.

  In the present invention, the ultraviolet blocking component may have a functional group that is covalently bonded to a protein residue on the surface of hair, skin, or fiber.

  Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le, can be at least one selected from the group consisting of disulfide and ketone, but are not limited thereto.

  In addition, the protein may include reactive residues such as thiol, hydroxyl, carboxyl, or amine.

  The carbodiimide-based compound is a generic term for compounds having a structure represented by the following chemical formula 1 in the molecule.

[Chemical Formula 1]
-N = C = N-

  The carbodiimide-based compound preferably includes at least about 1 to 1000 structures of the chemical formula 1, more preferably 1 to 100 structures represented by the chemical formula 1 in the molecule. More preferably, 1 to 10 structures represented by the formula are included in the molecule.

  In this case, if the number of carbodiimide groups represented by Chemical Formula 1 exceeds 1000 in one molecule, the viscosity of the raw material is very large, the molecular weight is very large, and the reaction positions that can be reacted are extremely excessive. The molecule having a carbodiimide group becomes very large, and a problem that the efficiency is lowered occurs by blocking a portion showing a functional effect of a molecule having a substantial function.

  In the present invention, specific examples of the carbodiimide-based compound can be a compound represented by the following chemical formula 2, wherein n is 4 and m is 11, 3, -bis (1-isocyanate-1-methylethyl)-, homopolymer, polyethylene glycol mono-ether-blocked (Benzene, 1, 3-bis (1-isocyanato-1-methylethyl)-, homopolymer, Polyethylene glycol mono-Me-ether-blocked) (hereinafter referred to as a polymer form carbodiimide-based compound of Formula 2).

  In the chemical formula 2, n is 1 to 100 and m is 1 to 100.

  As another example of the carbodiimide compound in the present invention, as a compound represented by the following chemical formula 3, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) Alternatively, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) can be used.

  As a preferred embodiment of the ultraviolet blocking composition according to the present invention, the ultraviolet blocking component having a carboxyl group is made in the form of a reactive ester ultraviolet blocking component having direct bioreactivity or hair (17.5 to 21.9). %), Skin keratin (15.5 to 23.5%) or fibers (19 to 23%) in an excessive amount of amino acids (for example, aspartic acid and glutamic acid) are reactively esterified to block UV rays containing amine groups. By using a carbodiimide-based compound that can be targeted by the component to make a reactive ester form (reactive UV blocking component) and increasing the reaction efficiency, the effect can be reliably increased. Other functionalities such as carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide that can target other amino acids. The effect can be further increased by using an ultraviolet blocking component containing a group in the molecule.

  As a more preferred embodiment, a carbodiimide-based compound of the formula 2 or 1-ethyl-3- (3-dimethylaminopropyl) is first applied to the surface of the UV blocking component molecule having a carboxyl group or the protein of skin or hair. A carbodiimide-type compound such as carbodiimide hydrochloride (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) undergoes a primary reaction to form a reactive ester, and an amine is further intramolecularly bound to the formed reactive ester functional group. An excellent ultraviolet blocking effect can be obtained by reacting the ultraviolet blocking component contained in the water or by reacting with an amine on the surface of hair, skin or fibers. At the time of the reaction, the reaction is preferably possible under the conditions of pH 2 to 10, more preferably, the reaction is preferably performed at pH 3 to 9, and most preferably the reaction is performed on an acidic or weakly acidic aqueous solution having a pH of about 4 to 5. Doing so can increase the reaction efficiency most. The reaction is completed within 1 to 30 minutes.

  Reaction in which a UV-blocking component molecule having a carboxyl group is first reacted with a carbodiimide compound to form a reactive ester, and then reacts with a biological amino acid having an amine residue to form a covalent bond. A schematic diagram is shown.

  In the following reaction formula 8, aspartic acid and glutamic acid, which are biological amino acids having a carboxyl group on the protein surface of hair, skin or fiber, undergo primary reaction with a carbodiimide compound to form a reactive ester, and subsequently have an amine residue. The reaction schematic diagram which reacts with an ultraviolet-blocking component and forms a covalent bond is shown.

  Reactive UV-blocking ingredients bound to hair, skin or fibers by increasing the reaction efficiency of hair, skin or fiber proteins and UV-blocking ingredients with carbodiimide-based compounds can be used for general cleaning with shampoos, detergents, soaps, etc. It becomes difficult to detach at the time of washing, and it can be maintained almost permanently attached to the hair, skin or fibers.

  The present invention also includes a carbodiimide group, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, Aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, Acrylonitrile, acrylic acid or methacrylic acid ester It may include reactive UV screening component which functional groups are bonded to form covalent bonds with one or more proteins selected from the group consisting of disulfides and ketones.

  For example, as shown in Reaction Formula 1, an ultraviolet blocking component to which a carbodiimide group generated by a primary reaction of a carbodiimide compound is bonded can be included. In addition, the present invention may include an ultraviolet blocking composition containing the reactive ultraviolet blocking component.

  In the composition for blocking ultraviolet rays according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear and branched long-chain alkyl quaternary ammonium salts are added to increase the effect incidentally. When mixed with a cationic surfactant such as cationized cellulose, cationized cellulose, cationized guar, cationized polymer such as cationized polyvinyl pyrrolidone, silicone, etc., formulation can be facilitated. In addition, for formulation into cosmetic preparations, solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH regulators, sequestering agents, colorants, pearling agents, appearance Ingredients for formulating cosmetic preparations such as improvers, pigments and powder particles can be incidentally included. The component for the formulation can be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the entire composition.

  The ultraviolet blocking composition according to the present invention includes a component having an ultraviolet blocking function having a functional group, and is used for the formulation of an ultraviolet blocking cosmetic composition. Examples of application of skin products are generally basic skin care (protection lotion, serum, essence, lotion, cream, etc.) and color cosmetics (makeup base, foundation, powder, eye shadow, lip glaze). , Lipstick, lip bum, etc.), nail makeup (manicure, nutrients, toughener, top coat, etc.), cosmetics for cleaning (foam cleansing, cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, Soap, cleansing tissue, etc.), suncare cosmetics, body cosmetics (body lotion, shower gel, body cream, body oil, etc.) can all be included, and even shampoos, rinses and trees in the hair , Hair packs, hair essences, waxes, gels, sprays, etc. In the case of textile products, fabric softeners, liquid detergents, powder detergents, sheet-type detergents, textile dyes, fibers All formulations of treatments, fiber rinses, bleaches, partial contamination treatments, fiber styling agents, ironing aids, clothing storage agents can be included.

  More preferably, the ultraviolet blocking composition according to the present invention includes a carbodiimide compound and at the same time includes an ultraviolet blocking component having a reactive functional group. It is easier to maintain its activity in the form, and it can be mixed with a buffer for pH adjustment just before use, or it can be made to react by contact with water in the washing process . Examples of non-aqueous dosage forms include liquid types, sheet types, powder powder types, tablet types, oils, waxes, ampoules, gels and the like used as ordinary non-aqueous cosmetic preparations. Further, the carbodiimide compound and the ultraviolet blocking component can be formulated into a single agent in an encapsulated form or two agents in a separated form. In addition, a method of blocking a derivative in a form in which a functional group having reactivity and a component having an ultraviolet blocking function are combined through encapsulation is also used.

  In order to increase the UV blocking effect having a functional group in the UV blocking composition according to the present invention, 2-basic acid ester oil such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, polyol, polyethylene glycol, propylene Glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The above-mentioned solvents are used as solvents for hardly soluble substances by increasing the permeability of hair, skin or fibers. More preferably, the solvent used for increasing the active fat and oil effect of the ultraviolet blocking component having a functional group includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

The present invention relates to a biobonding composition comprising a carbodiimide compound and a biobonding component.
The composition for bioconjugation according to the present invention is covalently bonded to a protein of hair or skin through a reactive bioconjugate component in which a carbodiimide group is bound by reacting a carbodiimide compound with a known bioconjugate component, for example. By forming, the biojoining effect can be maximized.

  The carbodiimide compound may be used in an amount of 0.001 to 10 parts by weight, 0.01 to 7 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire composition. If the content is less than 0.001 part by weight, there is a problem that a sustained biojoining effect is difficult to appear, and if it exceeds 50 parts by weight, a carbodiimide compound that is excessively present beyond the reaction position present on the skin is present in the skin. It exists in the state which does not react with and there exists a problem which can act as a component lost.

  In the present invention, the “biojoining effect” refers to a function of preventing or improving skin damage or hair cracking by effectively regenerating or joining a damaged part of living tissue such as skin or hair in its original state. Means.

  The bioconjugation components used in the present invention include fibrin, albumin, glucosamine, n-acetylglucosamine, alginate, hydrogel, growth factor, bioactive factor, necrotic tissue removing agent, split end bonding agent, antibacterial coating agent and the like. be able to. Examples of the growth factor include FGF (Fibroblast Growth Factor), KGF (Keratinocyte Growth Factor), VEGF (Vascular Endoelectric Growth Factor), and EGF (Epidmal Growth Growth). AB (Platelet Derived Growth Factor AB), PDGF-BB (Platelet Derived Growth Factor BB), TGF- (Transforming Growth Factor-), TGF-, Insulin-InliGli tor), TNF (Tumor Necrosis Factor), GM-CSF (Granulocyte Macrophage Colony Stimulating Factor), can be NGF (NerveGrowth Factor) or the like. Examples of the physiologically active factor include interferon, erythrocyte hematopoietic factor, 1L-1 (interleukin-1), IL-2, IL-6, and IL-8. The split hair bonding agent may be N- (4-carboxy-3-hydroxy-phenyl) maleimide, transglutaminate, and the like. Examples of the antibacterial coating agent include benzalkonium chloride, benzethonium chloride, halocarban, 2,4,4- 卜 -chloro-2-hydroxyphenol, triclosan, 卜 -licrocarban, isopropylmethylphenol, allatoin, ε-aminocapric acid, glycyl. It can be an acid or the like.

  The biomating component may be used in an amount of 0.001 to 50 parts by weight, 0.001 to 30 parts by weight, 0.01 to 10 parts by weight, or 0.1 to 5 parts by weight with respect to 100 parts by weight of the entire composition. Is preferred. If the content is less than 0.001 part by weight, there is a limit to the provision of the effect by the active ingredient, and if it exceeds 50 parts by weight, the ingredient is lost without being formulated and stabilized over time and reacting. There is a problem that acts as.

  In particular, the bioconjugate component in the present invention can increase the reaction efficiency with a carbodiimide compound by including a carboxyl group or an amine group in the molecule.

  In the present invention, the bioconjugation component may have a functional group that covalently bonds to a protein residue on the surface of hair or skin.

  Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le, can be at least one selected from the group consisting of disulfide and ketone, but are not limited thereto.

  In addition, the protein may include reactive residues such as thiol, hydroxyl, carboxyl, or amine.

  The carbodiimide-based compound is a generic term for compounds having a structure represented by the following chemical formula 1 in the molecule.

[Chemical Formula 1]
-N = C = N-

  The carbodiimide-based compound preferably includes at least about 1 to 1000 structures of the chemical formula 1, more preferably 1 to 100 structures represented by the chemical formula 1 in the molecule. More preferably, 1 to 10 structures represented by the formula are included in the molecule.

  In this case, when the number of carbodiimide groups represented by Chemical Formula 1 exceeds 1000 in one molecule, the viscosity of the raw material is very large, the molecular weight is extremely large, and the reaction positions where the reaction can be performed are extremely excessive. As a result, a molecule having a carbodiimide group becomes very large, and a portion that exhibits a functional effect of a molecule having a substantial function is blocked.

  In the present invention, specific examples of the carbodiimide-based compound can be a compound represented by the following chemical formula 2, wherein n is 4 and m is 11, 3, -bis (1-isocyanate-1-methylethyl)-, homopolymer, polyethylene glycol mono-ether-blocked (Benzene, 1, 3-bis (1-isocyanato-1-methylethyl)-, homopolymer, Polyethylene glycol mono-Me-ether-blocked) (hereinafter referred to as a polymer form carbodiimide-based compound of Formula 2).

  In Formula 2, n is 1 to 100 and m is 1 to 100.

  In the present invention, another example of the carbodiimide compound is a compound represented by the following chemical formula 3, which is 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl (1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) can be used.

  As a preferred embodiment of the composition for bioconjugation according to the present invention, a bioconjugate component having a carboxyl group is directly made into a reactive ester bioconjugate component form having bioreactivity or hair (17.5 to 21.9%). ) Or an amino acid (for example, aspartic acid, glutamic acid) present in an excessive amount in skin keratin (15.5 to 23.5%), and a carbodiimide compound capable of targeting a bioconjugate component containing an amine group. By using a reactive ester form (reactive bioconjugation component) to increase the reaction efficiency, the effect can be reliably increased. Other functionalities such as carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide that can target other amino acids. The effect can be further increased by using a bioconjugate component containing a group in the molecule.

  As a more preferable embodiment, a bioconjugate component molecule having a carboxyl group is first applied to the surface of a protein of skin or hair, firstly, a carbodiimide compound in a polymer form of Formula 2 or 1-ethyl-3- (3-dimethylaminopropyl). A carbodiimide-type compound such as carbodiimide hydrochloride (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide HCl) undergoes a primary reaction to form a reactive ester, and an amine is further intramolecularly bound to the formed reactive ester functional group. An excellent biojoining effect can be obtained by reacting the bioconjugate component contained in the skin or reacting with an amine on the surface of hair or skin. At the time of the reaction, the reaction is preferably possible under the conditions of pH 2 to 10, more preferably, the reaction is preferably performed at pH 3 to 9, and most preferably the reaction is performed on an acidic or weakly acidic aqueous solution having a pH of about 4 to 5. Doing so can increase the reaction efficiency most. The reaction is completed within 1 to 30 minutes.

  In the following reaction formula 9, a carbodiimide compound first reacts with aspartic acid or glutamic acid of skin and hair proteins having a carboxylic acid terminal to form a reactive ester, and subsequently exists in skin and hair proteins having an amine residue. The reaction schematic diagram which reacts with lysine and forms a covalent bond is shown.

  A bioconjugate substance that simultaneously contains skin and hair proteins containing cysteine amino acids and a maleimide that binds to cysteine, which is a biological amino acid, under the conditions of pH 7 to 8 as a biological reactive group in one molecule in the following reaction formula 10 Of Reactive Ester by Primary Reaction of 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide and Carbodiimide Compound 1-Ethyl Compound, and Scaling of Generated Reactive Ester and Amine Reaction of Hair Lysine Amino Acid Indicates.

  The carbodiimide-based compound increases the reaction efficiency of hair or skin proteins and bioconjugate components, and reactive bioconjugate components bound to hair or skin are less likely to be removed during general washing with shampoos, soaps, etc. It can be permanently attached to the hair or skin.

  The present invention also includes a carbodiimide group, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, Aldehyde, propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, Acrylonitrile, acrylic acid or methacrylic acid ester, It may include reactive bioconjugation component which functional groups are bonded to form covalent bonds with one or more proteins selected from the group consisting of sulfides and ketones.

  For example, as shown in Reaction Formula 1, a bioconjugate component to which a carbodiimide group generated by a primary reaction of a carbodiimide compound is bonded can be included. Moreover, this invention can contain the composition for bioconjugation containing the said reactive bioconjugation component.

  In the composition for bioconjugation according to the present invention, fatty acids such as palmitic acid and stearic acid, fatty alcohols, linear and branched long-chain alkyl quaternary ammonium salts are added to increase the effect incidentally. When mixed with a cationic surfactant such as cationized cellulose, cationized cellulose, cationized guar, cationized polymer such as cationized polyvinyl pyrrolidone, silicone, etc., formulation can be facilitated. Also, for formulation, solvents, surfactants, thickeners, stabilizers, preservatives, colorants, pH regulators, sequestering agents, colorants, pearling agents, appearance improvers, pigments Ingredients for formulation such as powder particles can be incidentally included. The component for the formulation can be used in an amount of 40 to 99 parts by weight based on 100 parts by weight of the entire composition.

  The composition for bioconjugation according to the present invention contains a component for bioconjugation function having a functional group, and is used for the formulation of a cosmetic composition for bioconjugation. Application examples of hair products include pre-shampoo compositions, shampoos, rinses, treatments, waxes, sprays, hair mousses, hair lotions, essences, hair creams, permanent hair dyes, temporary hair dyes, permanent agents. , Non-woven fabrics, sheets, etc., and skin products are generally applied as skin care products, basic cosmetics for protection (skin lotion, serum, essence, lotion, cream, etc.), color cosmetics (makeup) Bases, foundations, powders, eye shadows, lip glazes, lipsticks, lip bums, etc.) nail makeup (manicures, nutrients, strengthening agents, top coats, etc.), cleaning cosmetics (foam cleansing, cleansing oil, cleansing) Lotion, cleansing cream , A cleansing gel, pack, mask, soap, cleansing tissue paper, etc.), sun care cosmetics, it is possible to include all body for cosmetics (body lotion, shower gel, body cream, body oil, etc.).

  More preferably, the composition for bioconjugation according to the present invention comprises a carbodiimide-based compound and a bioconjugate component having a reactive functional group at the same time. It is easier to maintain its activity in the form, and it can be mixed with a buffer for pH adjustment just before use, or it can be made to react by contact with water in the washing process . Examples of non-aqueous dosage forms include liquid types, sheet types, powder powder types, tablet types, oils, waxes, ampoules, gels and the like used as ordinary non-aqueous cosmetic preparations. In addition, the carbodiimide compound and the bioconjugate component can be formulated into a single agent in an encapsulated form or two agents in a separated form. In addition, a method in which a derivative in a form in which a functional group having reactivity and a component having a biological bonding function are combined through encapsulation is shielded from moisture is also used.

  In order to increase the bioconjugation effect having a functional group in the bioconjugate composition according to the present invention, 2-basic ester oil such as dioctyl succinate, dioctyl adipate, diethyl sebacate and the like, polyol, polyethylene glycol, propylene Glycol, hexylene glycol, butanediol and isomers thereof, glycerol, benzyl alcohol, ethoxydiglycol and derivatives thereof can be used. The above-mentioned solvents increase the permeability of hair or skin and are used as solvents for hardly soluble substances. More preferably, the solvent used for increasing the active fat and oil effect of the bioconjugate component having a functional group includes diethyl sebacate, ethoxy glycol, bis-ethoxy glycol cyclohexane 1,4-dicarboxylate, and the like.

  Hereinafter, the present invention will be described in detail with reference to examples and experimental examples. However, the following examples and experimental examples are merely illustrative of the present invention, and the contents of the present invention are not limited to the following examples and experimental examples.

Examples 1 to 5 and Comparative Examples 1 to 2: Dyeing Compositions The compositions and contents shown in Table 1 below were used to produce the dyeing compositions of Examples 1 to 5 and Comparative Examples 1 to 2, and the compositions produced. 10 g of each product is dipped in white yak hair and wool cloth (5 cm * 5 cm) very similar to the protein composition of hair, reacted at 25 ° C. for 10 minutes, washed with flowing water, and washed with primary shampoo. Run, dry, compare and measure a * value (red), b * (blue) using a colorimeter, compare the amount of dye initially reacted, and treat the same yak hair and wool The fabric was shampooed and washed and dried 10 times, then dried, and the a * and b * values were compared and measured using a color difference meter to confirm the sustaining effect due to the reaction. (Comparative Example 1 and Example 1 used yak hair, Comparative Example 2 and Examples 3 to 5 used wool cloth for the experiment)

  Experimental results of Examples 1 to 5 and Comparative Examples 1 and 2 (Table 2), compared to Comparative Examples 1 and 2 dyed without carbodiimide as a dye in which the bioreactive group is not substituted, Example 2 in which the substituted derivative was used was evaluated as having excellent dyeability and sustainability, and was a stain prepared by reacting a carbodiimide compound and reacting with a reactive dye. No. 5 shows further excellent dyeability and durability due to the covalent bond forming effect of carbodiimide, and Examples 4 to 5 using the carbodiimide compound of the chemical formula 2 in the polymer form are most excellent in dyeability and dyeing sustaining effect. Indicates.

FIG. 1 is a photograph showing the dyed state of yak hair for Comparative Example 1 and Example 1 after dyeing under the above conditions and after shampooing 10 times.
FIG. 2 is a photograph showing the dyed state of the wool cloth for Examples 4 and 5 after dyeing under the above conditions, after one shampooing and after ten times shampooing.

Examples 6 to 12 and Comparative Examples 3 to 5: Moisturizing Compositions Compositions produced by producing the moisturizing compositions of Examples 6 to 12 and Comparative Examples 3 to 5 with the compositions and contents shown in Table 3 below. 10 g for each example was applied to 10 5 g hair tresses, allowed to stand at room temperature for 30 minutes to induce reaction, washed with primary water, then washed with 15% sodium lauryl sulfate aqueous solution. The process of drying and processing was repeated once. After that, the process of taking 1 g of hair out of these, quantifying the moisture content at a temperature of 60 ° C. using a dry weight loss balance to obtain a moisturizing amount, washing with a 15% aqueous solution of SLES, drying and processing is repeated 10 times. After that, another 1 g of hair was taken and the moisture content was quantified at a temperature of 60 ° C. using a dry weight loss balance to confirm the moisturizing effect.

  Experimental results of Examples 6 to 12 and Comparative Examples 3 to 5 (Table 4), derivatives substituted with bioreactive groups compared to Comparative Examples 3 to 5 that do not contain carbodiimide as a moisturizing component that is not substituted with bioreactive groups In the case of Example 6 using the above, it was evaluated that the moisture retention and the durability were excellent, and Examples 7 to 12 containing carbodiimide without replacing the bioreactive group are due to the covalent bond forming effect of carbodiimide. More excellent moisturizing property and sustainability are exhibited, and in particular, Examples 10 to 12 using polymer carbodiimide exhibit the most excellent moisturizing property and moisturizing effect.

Formulation Example 1: Production of moisturizing hair lotion A moisturizing cosmetic was produced with the components and contents shown in Table 5 below by an ordinary cosmetic production method.

Examples 13 to 19 and Comparative Examples 6 to 8: Conditioning compositions The compositions for hair conditioning of Examples 13 to 19 and Comparative Examples 6 to 8 were prepared with the compositions and contents shown in Table 6 below. A 10 g portion of the product was uniformly applied to a hair stress of about 4 g, and the reaction was induced by leaving it at room temperature for 30 minutes, followed by washing with primary water and shampoo to compare the initial conditioning effects. Thereafter, shampooed once a day, and after 10 days, the hair conditioning effect was scaled to 5 points (5: very excellent, 4: slightly excellent, 3: no difference, 2: no effect, 1: very ineffective) It was evaluated and compared with the sensuality.

  Experimental results of Examples 13 to 19 and Comparative Examples 6 to 8 (Table 7), compared to Comparative Examples 6 to 8 that were conditioned without carbodiimide as a conditioning component in which the bioreactive group was not substituted. In the case of Example 13 using a substituted derivative, it was evaluated that the conditioning effect and durability were excellent, and Examples 14 to 19 containing carbodiimide without replacing the bioreactive group formed covalent bonds of carbodiimide. According to the effect, more excellent conditioning effect and sustainability are exhibited, and in particular, Examples 17 to 19 using polymer carbodiimide exhibit the most excellent conditioning effect and conditioning sustaining effect.

Examples 20 to 26 and Comparative Examples 9 to 11: Conditioning Compositions Compositions produced by preparing hair conditioning compositions of Examples 20 to 26 and Comparative Examples 9 to 11 with the compositions and contents shown in Table 8 below. 10 g of the product was evenly applied to a hair trace of about 4 g, and the reaction was induced by leaving it at room temperature for 30 minutes, followed by washing with primary water and shampoo, and comparing the initial conditioning effect.
Thereafter, shampooed once a day, and after 10 days, the hair conditioning effect was scaled to 5 points (5: very excellent, 4: slightly excellent, 3: no difference, 2: no effect, 1: very ineffective) It was evaluated and compared with the sensuality.

  Experimental results of Examples 20 to 26 and Comparative Examples 9 to 11 (Table 9), derivatives substituted with bioreactive groups compared to Comparative Examples 9 to 11 that do not contain carbodiimide as a conditioning component in which bioreactive groups are not substituted In the case of Example 20 using the above, it was evaluated that the conditioning effect and the sustainability were excellent, and Examples 21 to 26 containing carbodiimide without replacing the bioreactive group had a covalent bond forming effect of carbodiimide, A more excellent conditioning effect and durability are shown, and Examples 24-26 using polymer carbodiimide show the most excellent conditioning effect and glossy effect.

Examples 27 to 30 and Comparative Examples 12 to 13: Conditioning compositions The compositions and contents shown in Table 10 below were used to produce the hair conditioning compositions of Examples 27 to 30 and Comparative Examples 12 to 13, and the compositions produced. Apply 10 g of the product uniformly to a hair stress of about 4 g, leave it at room temperature for 30 minutes to induce reaction, and repeat the process of washing with primary water and shampoo twice a day for 2 days. Dry hair, compare hair coating and volume immediately after treatment, shampoo once daily, 15 days later, hair coating and volume effect on a 5-point scale (5: very good, 4: slightly better, (3: No difference, 2: No effect, 1: Very ineffective).

Experimental Example Experimental results of Examples 27 to 30 and Comparative Examples 12 and 13 (Table 11) Examples 27 to 30 containing carbodiimide compared to Comparative Examples 12 and 13 containing no polymer but containing carbodiimide shared carbodiimide. Due to the bond forming effect, a more excellent hair volume effect is exhibited, and in particular, Examples 29 and 30 using polymer carbodiimide exhibit an excellent hair volume effect.

Formulation Example 2: Preparation of hair product for conditioning A hair product was prepared with the components and contents shown in Table 12 below by a conventional method of manufacturing a hair product.

Examples 31 to 38 and Comparative Examples 14 to 17: Compositions for blocking ultraviolet rays The compositions and contents shown in Table 13 below were used to produce the ultraviolet blocking compositions of Examples 31 to 38 and Comparative Examples 14 to 17, and the compositions produced. A process in which 3 g of each item is applied to the back of 10 subjects, left to stand for 30 minutes to induce a reaction, washed with primary water, then washed with soap and dried. Was repeated 2 days in the morning and 2 pm on the 1st, and after 5 days had passed, ultraviolet light was applied to the portion applied for 5 minutes every day for 3 days, and then a 5-point scale (5: very good, 4: Slightly excellent, 3: No difference, 2: No effect, 1: Very ineffective) Compared and confirmed the UV protection effect, and confirmed that UV protection substances were maintained for a long time by biological reaction and the effect appeared .

  Experimental results of Examples 31 to 38 and Comparative Examples 14 to 17 (Table 14), Examples 31 to 38 containing carbodiimide as compared to Comparative Examples 14 to 17 not containing carbodiimide are due to the covalent bond forming effect of carbodiimide. Further excellent UV blocking properties and sustainability were exhibited, and in particular, Examples 35 to 38 using polymer carbodiimide showed the most excellent UV blocking properties and UV blocking effectiveness.

Formulation Example 3: Production of UV-blocking cosmetics UV-blocking cosmetics with the components and contents shown in Table 15 below were produced by a conventional cosmetic production method.

Examples 39 to 40 and Comparative Example 18: Biobonding composition The hair bonding compositions of Examples 39 and 40 and Comparative Example 18 were manufactured with the compositions and contents shown in Table 16 below, and 3 g of the manufactured composition was 20 each. Apply evenly to the cracked part of the hair where the tips of the individual lines are broken, leave it at room temperature for 30 minutes to induce reaction, and repeat the process of washing with primary water and shampoo twice a day for 3 days The number of bonded hairs was compared.

Examples 41 to 42 and Comparative Example 19: Biobonding composition The two-part hair bonding compositions of Examples 41 and 42 and Comparative Example 19 were manufactured with the compositions and contents shown in Table 17 below. After uniformly applying 3 g of the composition to the cracked portion of the hair, each of which has 20 cracked ends, washed with flowing water, and then uniformly applying 3 g of the two-part composition to the broken portion of the hair The reaction was induced by leaving at room temperature for 30 minutes, and the process of washing with primary water and shampoo was repeated twice a day for 3 days, and the number of bonded hairs was compared.

  Experimental results of Examples 39 to 42 and Comparative Examples 18 and 19 (Table 18), Examples 39 and 40 containing carbodiimide compared to Comparative Example 18 containing ε-aminocapric acid without carbodiimide Due to the covalent bond forming effect, a more excellent hair binding effect is shown, and in particular, the case of Example 40 using a polymer carbodiimide shows a more excellent broken hair joining effect.

  In addition, even when N- (4-carboxy-3-hydroxy-phenyl) maleimide having a carboxyl group and a maleimide group in the molecule is used, when a carbodiimide-based compound is present, the results are similar to those of Examples 41 and 42. An excellent hair bonding effect was confirmed.

  FIG. 3 shows the hair state before and after treatment for the composition.

Formulation Example 4: Manufacture of biojoint cosmetics Bioconjugate cosmetics were prepared with the components and contents shown in Table 19 below by a conventional cosmetic manufacturing method.

Claims (52)

A carbodiimide compound; and a dye composition comprising a dye. The dye composition according to claim 1, wherein the carbodiimide compound is a carbodiimide compound represented by the following chemical formula 2:
In the chemical formula 2, n is 1 to 100 and m is 1 to 100. The dye composition according to claim 1, wherein the dye contains a carboxyl group or an amine group in the molecule. The dye composition according to claim 1, wherein the dye is a natural dye or a synthetic dye. The staining composition according to claim 4, wherein the natural dye is purpurin, mungistin, melanin or a melanin precursor. The synthetic dyes are Red No. 3, Red No. 104, Red No. 105, Red No. 201, Red No. 202, Red No. 220, Red No. 230, Red No. 231, Red No. 232, Red No. 401, Red No. 405, Yellow No. 4, Yellow 202, Orange No. 207, Red No. 106, Red No. 213, Red No. 214, Red No. 215, Yellow No. 404, Yellow No. 405, Blue No. 403, Disperse Blue 1 (Disperse Blue 1), Disperse Violet 1 (Disperse Violet 1), Disperse Orange 3 (Disperse Orange 3), Disperse Black 9 (Disperse Black 9), HC Blue 2 (HC Blue 2), HC Red 3 (HC Red 3), HC Yellow 5 (HC Yellow 5) Or the dyeing | staining composition of Claim 4 which is HC Red 1 (HC Red 1). The dye composition according to claim 1, wherein the dye has a functional group capable of covalently bonding to a protein residue on the surface of hair, skin, fiber, or skin. Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le is one or more selected from the group consisting of disulfide and ketone, stain composition of claim 7. The dye composition according to claim 1, wherein the carbodiimide-based compound is 0.001 to 10 parts by weight with respect to 100 parts by weight of the entire composition. The dyeing according to claim 1, wherein the carbodiimide compound and the dye are formulated into a single agent in an encapsulated form; or the carbodiimide compound and the dye are each formulated into two agents in a separate form. Agent composition. The dye comprises one or more selected from the group consisting of carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl and azide A reactive dye with a functional group that is covalently bonded to a protein. A dye composition comprising the reactive dye according to claim 11. A moisturizing cosmetic composition comprising a carbodiimide compound; and a moisturizing component. The moisturizing cosmetic composition according to claim 13, wherein the carbodiimide compound is a carbodiimide compound represented by the following chemical formula 2:
In the chemical formula 2, n is 1 to 100 and m is 1 to 100. The moisturizing cosmetic composition according to claim 13, wherein the moisturizing component contains a carboxyl group or an amine group in the molecule. The moisturizing component is glycerin, propylene glycol, butylene glycol, dipropylene glycol, capryl glycol, diglycerin, methyl glutes, ethoxydiglycol, glyceres, propanediol, diethoxydiglycol pyrrolidone carboxylic acid, sodium lactate, sodium PCA, mineral Oil, petrolatum, lanolin, jojoba oil, olive oil, glycosphingolipid, phospholipid, lipid mixture, isononyl isononanoate, betaine, carboxymethylchitin, ceramide, glucosylceramide, glucose aminoglucan, alpha-glucan, hyaluronic acid, Hydrolyzed hyaluronic acid, betaine, chitosan, chitosan succinamide, vitamin E (tocopherol), urea, hydro Sithyl urea, glucosides, gamma PGA, xylityl glucoside, xylitol, pentaerythrityl tetraisostearate, sodium chondroitin sulfate, chondroitin-4-sulfate, atelocollagen, beta glucan, PEG, pyridoxine tris-hexyl decanoate, potassium PCA Sodium polygamma-glutamate, polyglutamic acid, glyceryl polyacrylate, galactoarabinan, polyglycerin-3 crosspolymer, sodium hyaluronate, bis-PEG-18 methyl ether dimethylsilane, bis-ethoxydiglycol succinate, Lecithin, ascovir tetraisopalmitate, glycosyl trehalos, hydrogenated starch hydrol sate (Hydrogen) ted Starch Hydrolysate), 1,2-hexanediol, mannitol, arginine, serine, sucrose, PCA, citrulline, glycogen, histidine HCL, alanine, threonine, glutamic acid, lysine HCL, phosphate buffered saline (Phosphate Buffered Saline), Creatine, cholesteryl isostearate, cholesteryl chloride, cholesteryl nonanoate, BHT, sodium dilauramide glutamidricin, maltodextrin, polyquaternium-39, cholecalciferol PEG-12 ether, saccharide ismaleate, sorbitol and these The moisturizing cosmetic composition according to claim 13, which is one or more selected from the group consisting of derivatives. The moisturizing cosmetic composition according to claim 13, wherein the moisturizing component has a functional group capable of covalently bonding to a protein residue on the surface of hair or skin. Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le is one or more selected from the group consisting of disulfide and ketone, moisturizing cosmetic composition according to claim 17. The moisturizing cosmetic composition according to claim 13, wherein the carbodiimide-based compound is 0.001 to 10 parts by weight with respect to 100 parts by weight of the entire composition. 14. The carbodiimide compound and the moisturizing component are formulated into a single agent in an encapsulated form; or the carbodiimide compound and the moisturizing component are each formulated into two agents in a separated form. Cosmetic composition for moisture retention. One or more selected from the group consisting of carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl and azide Reactive moisturizing component to which a functional group covalently bonded to the protein of is attached. A moisturizing cosmetic composition comprising the reactive moisturizing component according to claim 21. A conditioning cosmetic composition comprising a carbodiimide compound; and a conditioning component. The conditioning cosmetic composition according to claim 23, wherein the carbodiimide compound is a carbodiimide compound represented by the following chemical formula 2:
In the chemical formula 2, n is 1 to 100 and m is 1 to 100. The conditioning cosmetic composition according to claim 23, wherein the conditioning component contains a carboxyl group or an amine group in the molecule. 24. The conditioning component of claim 23, wherein the conditioning component is one or more selected from the group consisting of polymers, fatty amines, silicones, fatty alcohols, fatty acids, waxes, ester oils and derivatives thereof. Conditioning cosmetic composition. 24. A conditioning cosmetic composition according to claim 23, wherein the conditioning component has a functional group capable of covalent bonding with a protein residue on the surface of hair or skin. Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le is one or more selected from the group consisting of disulfide and ketone, conditioning cosmetic composition of claim 27. The conditioning cosmetic composition according to claim 23, wherein the carbodiimide-based compound is 0.001 to 10 parts by weight with respect to 100 parts by weight of the entire composition. 24. The carbodiimide compound and the conditioning component are formulated into a single encapsulated form; or the carbodiimide compound and the conditioning component are each formulated into two separate forms. Conditioning cosmetic composition. The conditioning component includes at least one selected from the group consisting of carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, and azide. Reactive conditioning component with a functional group that is covalently bonded to the protein. A conditioning cosmetic composition comprising the reactive conditioning component of claim 31. An ultraviolet blocking composition comprising a carbodiimide compound; and an ultraviolet blocking component. 34. The ultraviolet blocking composition according to claim 33, wherein the carbodiimide compound is a carbodiimide compound represented by the following chemical formula 2:
In the chemical formula 2, n is 1 to 100 and m is 1 to 100. 34. The ultraviolet blocking composition according to claim 33, wherein the ultraviolet blocking component contains a carboxyl group or an amine group in the molecule. The ultraviolet blocking component is cinnamic acid, glyceryl PABA, drometrizole, digalloyl trioleate, 3, (4-methylbenzylidene) camphor, menthyl anthranilate, benzophenone-3, benzophenone-4, benzophenone-8, butyl Methoxybenzoylmethane, sinoxate, adenine riboside, octocrylene, octyldimethyl PABA, octylmethoxycinnamate, octyl salicylate, octyl triazone, paraaminobenzoic acid, 2-benzimidazole-5-sulfonic acid, homosalate, zinc oxide, titanium dioxide , Isoamyl-p-methoxycinnamate, bisethylhexyloxyphenol methoxyphenyl triazine, disodium phenyl dibenzimidazole tetrasulfone , Amodi-drometrizole trisiloxane, diethylhexylbutamide triazone, polysilicone-15 (dimethicodiethylbenzal malonate), methylenebis-benzotriazolyltetramethylbutylphenol, terephthalidene dicamphorsulfonic acid and its salts 34. The ultraviolet blocking composition according to claim 33, wherein the composition is one or more selected from the group consisting of: 34. The ultraviolet blocking composition according to claim 33, wherein the ultraviolet blocking component has a functional group capable of covalent bonding with a protein residue on the surface of hair, skin or fibers. Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le is one or more selected from the group consisting of disulfide and ketone, ultraviolet blocking composition according to claim 37. 34. The ultraviolet blocking composition according to claim 33, wherein the carbodiimide-based compound is 0.001 to 10 parts by weight with respect to 100 parts by weight of the entire composition. 34. The carbodiimide compound and the UV blocking component are formulated into a single agent encapsulated form; or the carbodiimide compound and the UV blocking component are each formulated into two separate forms. The composition for ultraviolet shielding described in 1. One selected from the group consisting of carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, and azide as the UV blocking component A reactive ultraviolet blocking component having a functional group covalently bonded to the above protein. 42. An ultraviolet blocking composition comprising the reactive ultraviolet blocking component of claim 41. A biobonding composition comprising a carbodiimide compound; and a biobonding component. The biobonding composition according to claim 43, wherein the carbodiimide compound is a carbodiimide compound represented by the following chemical formula 2:
In the chemical formula 2, n is 1 to 100 and m is 1 to 100. 44. The bioconjugate composition according to claim 43, wherein the bioconjugate component contains a carboxyl group or an amine group in the molecule. The bioconjugation component is selected from the group consisting of fibrin, albumin, glucosamine, n-acetylglucosamine, alginate, hydrogel, growth factor, bioactive factor, necrotic tissue removing agent, split end bonding agent and antibacterial coating agent. 44. The composition for bioconjugation according to claim 43, wherein the composition is one or more. 44. The composition for bioconjugation according to claim 43, wherein the bioconjugation component has a functional group capable of covalent bonding with a protein residue on the surface of hair or skin. Functional groups covalently bonded to the protein include carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl, azide, carbonate, aldehyde , Propionaldehyde, butyraldehyde, nitrophenyl carbonate, aziridine, isocyanate, thiocyanate, epoxide, tosyllate, succinimide, hydroxysuccinimidyl ester, imidazole, oxycarbonylimidazole, imine, thiol, maleimide, vinylsulfone, ethyleneimine, thioether, acrylonitrile , Acrylic acid or methacrylate Le is one or more selected from the group consisting of disulfide and ketone, biological bonding composition of claim 47. 44. The biobonding composition according to claim 43, wherein the carbodiimide-based compound is 0.001 to 10 parts by weight with respect to 100 parts by weight of the entire composition. 44. The carbodiimide compound and the bioconjugate component are formulated into a single agent in an encapsulated form; or the carbodiimide compound and the bioconjugate component are each formulated into two separate forms. The composition for bioconjugation according to 1. One selected from the group consisting of carbodiimide, imide ester, allyl azide, diazirine, hydroxymethylphosphine, pentafluorophenyl ester, pyridyl disulfide, sulfo-hydroxysuccinimide ester, alkoxyamine, hydrazide, haloacetyl and azide A reactive bioconjugate component to which a functional group covalently bonded to the above protein is bonded. A bioconjugate composition comprising the reactive bioconjugate component according to claim 51.