KR102665107B1 - Cosmetic composition for skin regeneration - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin regeneration, and more specifically, to a core comprising a hydrogel and an ionic surfactant; A shell layer surrounding the core and containing an organic material including cica component, madecassoside, chitosan, ceramide, panthenol, and sodium polyacrylate starch; and a hydrogel layer surrounding the shell layer; a composite particle comprising a; It relates to a cosmetic composition for skin regeneration, including.

Description

Cosmetic composition for skin regeneration {COSMETIC COMPOSITION FOR SKIN REGENERATION}

The present invention relates to a cosmetic composition for skin regeneration.

The skin is histologically composed of three layers: epidermis, dermis, and subcutis. The epidermis is the outermost layer and plays the most important role in terms of skin aging and skin beauty. It is also the subject of the most intensive research. The components that make up the stratum corneum, the outermost layer of the epidermis, are keratinocytes and skin lipids. Skin lipids are responsible for the skin's barrier function. This barrier function of the skin regulates cell division and differentiation of the keratin to protect the skin from external harmful substances. It can be said to be an important function to protect, prevent the outflow of body substances, and prevent moisture evaporation from the skin. Recently, laser procedures for cosmetic purposes such as mole removal, removal of blemishes (blemishes, freckles, age spots, etc.), wrinkle removal, scar removal, tattoo removal, skin care procedures such as tattooing (eyebrows or full body), radiofrequency treatment, and dermabrasion ( Skin treatments such as peeling are widely used, and after such skin procedures or treatments, skin tissue may be damaged or scarred, and pigmentation, scars, or scars may occur during the healing process. To heal skin damage or wounds of various causes, prevent and protect the wound area from bacterial infection or other secondary damage while activating skin physiological functions (or skin metabolism) to promote skin tissue regeneration and natural exfoliation. It must be done well. Accordingly, the present invention is intended to provide a cosmetic composition for skin regeneration in which the active ingredient is effectively formulated and has skin barrier strengthening, skin regeneration, and skin protection functions while increasing stability.

According to one embodiment, in order to solve the above-mentioned problems, the present invention provides excellent physical or chemical stability of the functional material or active ingredient, releases the functional material or active ingredient within the skin surface or skin cell layer, or releases the functional material or active ingredient within the skin cell layer. The aim is to provide a cosmetic composition for skin regeneration containing composite particles that can effectively function.

However, the problems to be solved by the present invention are not limited to those mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

According to embodiments of the present disclosure, a cosmetic composition for skin regeneration includes a core including a hydrogel and an ionic surfactant; Surrounding the core, cica component, madecassoside, chitosan, ceramide, panthenol and sodium polyacrylate starch; A shell layer containing an organic material containing; and a hydrogel layer surrounding the shell layer; Composite particles containing; may include.

According to one embodiment, the cica component is 1% to 30% by weight of the organic material, and the cica component is Centella asiatica extract, madecassoside, and asiaticoside. It may contain at least one of (Asiaticoside), Madecasic acid, or Asiatic acid, or a combination thereof.

According to one embodiment, the chitosan is a low molecular weight chitosan of 5,000 to 10,000 daltons (Da), and the chitosan, ceramide, panthenol, and sodium polyacrylate starch may each be 1% to 20% by weight of the organic material. there is.

According to one embodiment, the shell layer includes at least one of tocopheryl acetate, vinegar, and adenosine, or a combination thereof; It further includes, and each of these may be included in an amount of 10 to 20 parts by weight based on 100 parts by weight of the organic material.

According to one embodiment, the hydrogel is at least one of hyaluronic acid hydrogel, gelatin hydrogel, chitosan hydrogel, poly (ethylene glycol), poly (hydroxyethyl methacrylate)), or polyvinyl alcohol hydrogel. or a combination thereof, and the hydrogel may have a crosslinking degree of 1% to 50%.

According to one embodiment, the hydrogel may have a molecular weight of 300 kDa to 1,000 kDa.

According to one embodiment, the hydrogel includes hyaluronic acid (excluding hyaluronic acid hydrogel), poly-γ-glutamic acid, cellulose, and polyacrylic acid. It may be modified with at least one of acid, polyamino acid, or alginate.

According to one embodiment, the hydrogel includes polyethylene glycol (PEG)-based crosslinking agents, disulfide-based crosslinking agents, dialdehydes, and multi-epoxides. ) or a crosslinking agent containing at least one or a combination of carbodiimides, and the crosslinking agent may be included in an amount of 0.1 parts by weight to 2 parts by weight based on 100 parts by weight of the hydrogel. .

According to one embodiment, the crosslinking agent is 1,4-butanediol diglycidyl ether (BDDE), 1,2-ethanediol diglycidyl ether (1,2-ethanediol diglycidyl ether) , EDDE), or pentaerythritol tetraglycidyl ether (PETGE), or a combination thereof.

According to one embodiment, the ionic surfactant may include 10 parts by weight to 20 parts by weight based on 100 parts by weight of the hydrogel of the core.

According to one embodiment, the ionic surfactant includes a cationic surfactant and an anionic surfactant, and the cationic surfactant is cocoyl hydroxyethylimidazolinium lauryl/myristril trimethyl Ammonium methosulfate or cetyl trimethyl ammonium bromide, and the anionic surfactant may be sodium dodecyl sulfate, palmitate, or sodium dodecylbenzenesulfonate (SDBS).

According to one embodiment, the core further includes a nonionic surfactant, and the nonionic surfactant is polyglyceryl-3 polyricinoleate, polyglyceryl-2 sesquiisostearate, polyglyceryl -Contains at least one of 2triisostearate, polyglyceryl-3methylglucose distearate, polyglyceryl-6stearate, polyglyceryl-6behenate, and polyglyceryl-6polyricinoleate; , the nonionic active agent may be 1 part by weight to 50 parts by weight based on 100 parts by weight of the ionic surfactant.

According to one embodiment, the core includes at least one of titanium ions, silicon ions, magnesium ions, calcium ions, potassium ions, zinc ions, or iron ions, or a combination thereof; And it may further include at least one or a combination of a chelating agent, vitamin C, aloe gel, vitamin B1, xylitol, retinol, Cordyceps sinensis, or squalene.

According to one embodiment, the shell layer includes inorganic oxide-based particles; It further includes, wherein the inorganic oxide-based particles are included in a mass ratio of 0.5 to 5 with respect to the organic material, and the inorganic oxide-based particles are at least one of silica, zinc oxide, titanium oxide, kaolin, magnesium oxide, and iron oxide. It may include the above or a combination thereof.

According to one embodiment, the size of the inorganic oxide-based particles may be 500 nm to 10 ㎛.

According to one embodiment, the composite particles may be tubes, fibers, oval-shaped, plate-shaped or spherical particles, and the size of the composite particles may be 10 ㎛ to 800 ㎛.

According to one embodiment, the core and the hydrogel layer may each be porous with pores of 50 nm to 500 nm.

According to one embodiment, the hydrogel layer may include a non-crosslinked hydrogel, and the hydrogel layer may include a non-crosslinked hydrogel of the same or different hydrogel as the core.

According to one embodiment, the shell layer may further include an adhesion enhancer.

According to one embodiment, the cosmetic composition may be a stick-type balm, lotion, powder, cream, or ampoule.

According to one embodiment, the cosmetic composition may be applied to the skin after a tattoo procedure or after tattoo removal.

According to one embodiment, the cosmetic composition includes a phase change material including at least one of xanthan gum, gelatin, sodium alginate, pectin, carrageenan, or guar gum, or a combination thereof; and at least one of ethanol, butanol, dipropylene glycol, erythritol, sorbitol, glycerol, propanediol, 1,3-butylene glycol, diethylene glycol, or isopentyldiol, or a combination thereof.

According to one embodiment, the present invention can provide a cosmetic composition having skin soothing and skin regenerative functions. According to one embodiment, the present invention can not only soothe and protect damaged skin due to irritation (e.g., heat, light, physical or chemical stimulation, etc.), wounds, enlarged pores, etc., but also provide a skin regenerative function. Additionally, the present invention provides a cooling effect to soothe damaged skin such as irritation (e.g. heat, light, physical or chemical irritation, etc.), wounds, enlarged pores, etc.

According to one embodiment, the present invention may provide skin soothing and regenerative functions after skin procedures or treatments (e.g., tattooing, peeling, laser irradiation, high-frequency irradiation, etc.).

Hereinafter, the cosmetic composition for skin regeneration of the present invention will be described in detail with reference to examples. However, the present invention is not limited to these examples and drawings.

According to one embodiment, the cosmetic composition for skin regeneration of the present invention includes a core; and a shell layer on the core; And it may include a composite particle including a hydrogel layer on the shell layer.

According to one embodiment, the core may include a hydrogel and an ionic surfactant. The hydrogel includes a cross-linked hydrogel and can stably maintain the components of the shell layer in a solvent or formulation and facilitate their function or release in the application target. According to one embodiment, the hydrogel of the core is biocompatible and applicable to living organisms, and includes hyaluronic acid, gelatin, chitosan, poly(ethylene glycol), poly(hydroxyethyl methacrylate)) or polyvinyl alcohol. It may be a hydrogel containing at least one or a combination thereof. Their molecular weight may be 300 kDa to 1,000 kDa, 300 kDa to 900 kDa, 300 kDa to 500 kDa or 300 kDa to 400 kDa. or their molecular weight (Mw) (e.g. synthetic polymers) is 100,000 (g/mol) to 1,000,000 (g/mol); 100,000 (g/mol) to 700,000 (g/mol); 200,000 (g/mol) to 500,000 (g/mol); or 200,000 (g/mol) to 300,000 (g/mol). According to one embodiment, the solubility of the composite particles can be set by adjusting the molecular weight of the hydrogel. According to one embodiment, the hydrogel may be manufactured by a method known in the art of the present invention, and is not specifically mentioned in the present specification.

According to one embodiment, the hydrogel of the core is hyaluronic acid hydrogel, gelatin hydrogel, chitosan hydrogel, poly(ethylene glycol) hydrogel, poly(hydroxyethyl methacrylate)) hydrogel, or polyvinyl alcohol. It may include at least one hydrogel, or a combination thereof. Preferably, it may be a hyaluronic acid hydrogel. The molecular weight of the hydrogel of the core may be 300 kDa to 1,000 kDa, 300 kDa to 900 kDa, 300 kDa to 500 kDa, or 300 kDa to 400 kDa. or the molecular weight (Mw) of the hydrogel of the core is 100,000 (g/mol) to 1,000,000 (g/mol); 100,000 (g/mol) to 700,000 (g/mol); 200,000 (g/mol) to 500,000 (g/mol); or 200,000 (g/mol) to 300,000 (g/mol). According to one embodiment, the solubility of the composite particles can be set by adjusting the molecular weight of the hydrogel.

According to one embodiment, the hydrogel of the core may be transparent, translucent, or opaque. According to one embodiment, the light transmittance (measured by standard methods, e.g. visible light) (e.g. light wavelength: 500 nm to 600 nm) of the hydrogel of the core is 10% or more; 20% or more; More than 50%; More than 80%; Or it may be 90% or more. Preferably it may be 40% to 80%. By controlling the light transmittance of the core, it can be used for visual or aesthetic effects of cosmetic compositions.

According to one embodiment, the viscosity of the hydrogel of the core is 100 cp to 100,000 (cp, room temperature (rt) or 25° C.); 1000 cp to 100,000 (cp, room temperature (rt) or 25°C); or 100 cp to 10,000 (cp, room temperature (rt) or 25°C). This viscosity improves bonding or adhesion to the skin and/or shell layer and provides a soft feeling of use in particle form.

According to one embodiment, the crosslinking degree of the hydrogel of the core is 1% to 50%; 1% to 40%; 1% to 30%; 5% to 20%; Or it may be 5% to 15%. It may be preferable. That is, by adjusting the degree of cross-linking, it can be used as a carrier for the morphological stability of the shell layer and the functional material or active ingredient of the shell layer, and can be easily removed during the cleaning process. Preferably, the degree of crosslinking is 5% to 10%; Or it may be 8% to 15%.

According to one embodiment, the core is made of hyaluronic acid (except in the case of hyaluronic acid hydrogel), poly-γ-glutamic acid, cellulose, polyacrylic acid ( It may further include at least one of polyacrylic acid, polyamino acid, or alginate, or a combination thereof. These are 0.1 to 1 with respect to the main component of the hydrogel; 0.5 to 1; Alternatively, it may be included at a molar ratio of 0.5 to 0.8.

According to one embodiment, the hydrogel of the core includes hyaluronic acid (except in the case of hyaluronic acid hydrogel), poly-γ-glutamic acid, cellulose, It may be modified with at least one of polyacrylic acid, polyamino acid, or alginate, or a combination thereof. However, components identical to the produced hydrogel are excluded. These are 0.1 to 1 with respect to the main component of the hydrogel; 0.5 to 1; Alternatively, it may be modified at a molar ratio of 0.5 to 0.8. In other words, this can improve mechanical strength, viscosity, and shape retention by lowering the crosslinking agent content. For example, it may be an alginate-hyaluronic acid hydrogel.

According to one embodiment, the hydrogel of the core contains polyethylene glycol (PEG)-based crosslinking agents, disulfides, dialdehydes, and multi-epoxide crosslinking agents. -epoxides) or carbodiimide-based crosslinking agents (carbodiimides) or a combination thereof. More specifically, the crosslinking agent is 1,4-butanediol diglycidyl ether (BDDE), 1,2-ethanediol diglycidyl ether (EDDE) , pentaerythritol tetraglycidyl ether (PETGE), 1,2-bis(2,3-epoxypropoxy)ethylene (EGDGE), 1,2,7,8-diepoxyoctane (DEO), phenylene-bis-(ethyl)-carbodiimide (PBEC), 1,6-hexamethylene bis-(ethylcarbodiimide), adipic dihydrazide (ADH), bis (sulfosuccinimidyl) ) Suberate (bis(sulfosuccinimidyl)suberate, BSS), hexamethylenediamine (HMDA), 1-(2,3-epoxypropyl)-2,3-epoxycyclohexane (1-(2,3-epoxypropyl) It may include at least one of -2,3- epoxycyclohexane (EECH) or divinyl sulfone (DVS), or a combination thereof.

According to one embodiment, preferably the crosslinking agent is 1,4-butanediol diglycidyl ether (BDDE), 1,2-ethanediol diglycidyl ether (1,2- It may include at least one of ethanediol diglycidyl ether (EDDE), pentaerythritol tetraglycidyl ether (PETGE), or a combination thereof.

According to one embodiment, the cross-linking agent is greater than 0 to 2 parts by weight based on 100 parts by weight of the hydrogel; 0.001 to 2 parts by weight; 0.01 to 2 parts by weight; 0.01 to 1.5 parts by weight; 0.1 to 1 part by weight; It can be added in an amount of 0.01 to 0.5 parts by weight to crosslink the hydrogel.

According to one embodiment, the hydrogel is stored at room temperature to 90°C; Room temperature to 70°C; Room temperature to 60°C; or at room temperature to 40° C. for 1 minute or more; 10 minutes or more; More than 1 hour; More than 10 hours; More than 20 hours; Alternatively, the crosslinking reaction may proceed for 15 to 20 hours.

According to one embodiment, the core may be tube-shaped, fiber-shaped, oval-shaped, plate-shaped, or spherical. According to one embodiment, the core has pores and may include disordered porosity or lattice-shaped pores. Through these pores, the shell layer can be stably supported or the function of functional substances or active ingredients can be activated in the skin.

According to one embodiment, the ionic surfactant is 1 part by weight to 50 parts by weight based on 100 parts by weight of the hydrogel; 1 to 30 parts by weight; 1 to 20 parts by weight; 2 to 15 parts by weight; 2 to 10 parts by weight; Or it may be 5 to 8 parts by weight. By applying this amount of ionic surfactant, the formulation can be formed well, and the cosmetic composition (or composite particles) can be effectively removed during the cleaning process.

According to one embodiment, the cationic surfactant includes ethoxylated tallow amine, amine salts such as cocoalkylamine and oleylamine, cetyl trimethyl ammonium bromide, myristyl trimethyl ammonium bromide, stearyl dimethyl benzyl Ammonium Chloride, Lauryl/Myristril Trimethyl Ammonium Methosulfate, Stearyl Octyldimonium Methosulfate, Palmoylethyl Dihydrogenated Hydroxyethylmonium Methosulfate, Isostearyl Benzylimidonium Chloride, Cocoyl Benzyl Hydroxyethyl Imidazole It may include at least one or a combination of quaternary ammonium compounds such as inium chloride, cocoyl hydroxyethylimidazolinium, or mixtures thereof, but is not limited thereto. Preferably, the cationic surfactant may be cocoyl hydroxyethylimidazolinium lauryl/myristril trimethyl ammonium methosulfate or cetyl trimethyl ammonium bromide.

According to one embodiment, the anionic surfactant is an alkyl sulfate salt, such as alkyl sulfate, alkyl ether sulfate, alkyl isotinate, alkyl carboxylate, alkyl sulfosuccinate, alkyl succinamate, sodium dodecyl sulfate, Alkyl sarcosinates, alkyl derivatives of protein hydrolysis products, acyl aspartates, alkyl or alkyl ethers or alkylaryl ether phosphate esters, sodium dodecyl sulfate, ammonium stearate, oleate or palmitate, sodium dodecylbenzenesulfo. alkylarylsulfonates such as nitrates (SDBS), sodium dialkylsulfosuccinate, dioctyl sulfosuccinate, sodium dilaurylsulfosuccinate, poly(styrene sulfonates) and their salts or isobutylene- It may include, but is not limited to, at least one of maleic anhydride copolymers or a combination thereof (here, alkyl is a straight-chain or branched-chain alkyl having 1 to 20 carbon atoms). Preferably, the anionic surfactant may be sodium dodecyl sulfate, palmitate, or sodium dodecylbenzenesulfonate (SDBS).

According to one embodiment, the mixing ratio of the cationic surfactant to the anionic surfactant may be 1:1 to 1:5 (w/w). By applying this mixing ratio, the formulation can be formed well, and the cosmetic composition or composite particles can be effectively removed during the cleaning process.

According to one embodiment, the core further includes a nonionic surfactant, and the nonionic surfactant is polyglyceryl-3 polyricinoleate, polyglyceryl-2 sesquiisostearate, polyglyceryl -2triisostearate, polyglyceryl-3methylglucose distearate, polyglyceryl-6stearate, polyglyceryl-6behenate or polyglyceryl-6polyricinoleate; or a combination thereof, wherein the nonionic surfactant is 1 part by weight to 50 parts by weight based on 100 parts by weight of the ionic surfactant; It may be 1 part by weight to 30 parts by weight or 1 part by weight to 20 parts by weight. By adding the nonionic surfactant, dispersibility within the formulation can be controlled.

According to one embodiment, the shell layer may be coated on the core, surround the core, or be impregnated into a certain volume of the core. According to one embodiment, the shell layer includes an organic functional material, and the shell layer may include an organic material including cica component, madecassoside, chitosan, ceramide, panthenol, and sodium polyacrylate starch. . According to one embodiment, the organic material may provide a skin regenerative function, a soothing function, etc., and may be comprised of 1% to 20% by weight of the composite particles; 2% to 15% by weight; Alternatively, it may be included in 5% to 10% by weight. By applying the above content range, it can be stably maintained within the composite particle and provide skin regeneration and/or soothing functions.

According to one embodiment, the cica component is 1% to 30% by weight of the organic material, and the cica component is Centella asiatica extract, madecassoside, asiaticoside ( It may include at least one of Asiaticoside, Madecasic acid, or Asiatic acid, or a combination thereof. According to one embodiment, the cica component may have a mass ratio of madecassoside to two or more of the remaining components or all of the remaining components of 1:0.5 to 2.

According to one embodiment, the molecular weight (Da) of the chitosan is 200 to 100,000 Dalton (Da); 200 to 10,000 daltons (Da); 200 to 10,000 daltons (Da); 2000 to 10,000 daltons (Da); 2,000 to 10,000 daltons (Da); It may be 5,000 to 10,000 daltons (Da) or 2,000 to 3,000 daltons (Da). Preferably, the chitosan may be a low molecular weight chitosan of 5,000 to 10,000 daltons (Da) or 2,000 to 3,000 daltons (Da). In one embodiment, EEK, the chitosan is composed of two types of chitosan with molecular weights of 5,000 to 10,000 daltons (Da) and 2,000 to 3,000 daltons (Da) at a ratio of 1:1 to 2 (mass ratio of high molecular weight: low molecular weight chitosan). Can be mixed.

According to one embodiment, the chitosan, ceramide, panthenol, and sodium polyacrylate starch are each included in the organic material in an amount of 1% to 20% by weight; 2% to 20% by weight; 5% to 15% by weight; Or it may be 5% to 10% by weight. According to one embodiment, the mass ratio of the cica component to the chitosan is 1:0.5 to 2; Or it may be 1:1 to 2:1.

According to one embodiment, the mass ratio of the cica component to ceramide to panthenol to sodium polyacrylate starch is 1:0.5 to 2:0.5 to 2:0.5 to 2 or 1:1 to 2:1 to 2:1 to 2 days. You can. By applying this mixing ratio, skin regeneration, moisturizing effect, and/or skin soothing effect can be improved.

According to one embodiment, chitosan is a natural animal marine polymer that has the only positive ion in nature, and chitosan, which is a raw material of chitosan, is a deacetylation product obtained by deacetylating chitin obtained from the shell of crustaceans. In addition, it is compatible with the human body, has no side effects, is non-irritating, and is safe for the body. It acts on the skin to provide exfoliation, antibacterial, moisturizing, skin regeneration, cell activation, skin protective film formation, and impurity adsorption. You can. The chitosan is 80% to 100%; 90 to 100%; or has a degree of deacetylation (DA) within the range of 95 to 100% (less than), 0.1 ㎛ (micrometer) to 100 ㎛ (micrometer); 0.3 μm (micrometer) to 50 μm (micrometer); 0.5 μm (micrometer) to 10 μm (micrometer); 0.8 μm (micrometer) to 5 μm (micrometer); or may be fibrous (i.e., thickness) or powdery particles (i.e., particle diameter) with a particle size of 0.8 μm (micrometer) to 1 μm (micrometer). By applying the mentioned particle size, mixing with organic substances can be achieved well, and adsorption or support on the core can be achieved well.

According to one embodiment, the ceramide may be a type of sphingolipid having a structure in which a fatty acid is linked to sphingosine or phytosphingosine. The ceramide is decomposed into phytosphingosine on the skin surface, thereby acting as an antibacterial barrier against external harmful microorganisms and providing inflammation control and wound recovery functions. In addition, it is intended to form a solid defensive barrier of the skin, and can maintain the ordered structure of the lipid barrier and stratum corneum that suppress evaporation of moisture.

According to one embodiment, panthenol is an alcohol derivative of panthenonic acid (vitamin B5) and is called water-soluble provitamin B5. Panthenonic acid is a component of CoA (Coenzyme A), a coenzyme that plays an important role in the metabolism of all cells. Panthenol provides a moisturizing effect by strengthening water tension, improves moisture supply to the skin, reduces skin itching and inflammation, and improves wound healing and skin elasticity.

According to one embodiment, sodium polyacrylate starch is hypoallergenic, is excellent in keratin regeneration and skin moisturizing, and is especially excellent in skin exfoliation effect. In addition, it can improve the absorption and stability of the cosmetic composition (i.e., composite particles) and help maintain viscosity.

According to one embodiment, the shell layer may further include at least one or a combination of tocopheryl acetate, asiaticoside, vinegar, and adenosine, which may provide skin elasticity, moisturizing, and/or regenerative functions. You can. Each of these may be included in an amount of 10 to 20 parts by weight based on 100 parts by weight of the organic material, or may be 0.001 to 1% by weight in the cosmetic composition. These may be included in the shell layer or added to the cosmetic composition formulation.

According to one embodiment, the shell layer may further include hydrophobic silica, silica silylate, silica dimethyl silylate, silica dimethicone silylate, and silica caprylyl silylate. Each of these may be included in a mass ratio of 0.1 to 5 mass ratio with respect to the organic material. It is possible to improve the adhesion between the shell layer and the target (e.g. skin) to which the cosmetic composition is applied.

According to one embodiment, the shell layer may further include inorganic oxide-based particles. The inorganic oxide-based particles may be included in a mass ratio of 0.1 to 10 mass ratio with respect to the organic material. For example, the inorganic oxide-based particles may include at least one of silica, zinc oxide, titanium oxide, kaolin, magnesium oxide, or iron oxide (e.g., (II) or (III)) or a combination thereof. . According to one embodiment, the inorganic oxide-based particles can protect the skin by providing a UV blocking function that absorbs UV rays (eg, UVA and UVB). Additionally, functional ingredients (e.g., organic materials) of the shell layer are adsorbed and fixed to their surface, thereby improving stability within the formulation. According to one embodiment, the size of the inorganic oxide-based particles is 200 nm to 10 ㎛; 500 nm to 10 μm; 300 nm to 5 μm; 500 nm to 2 μm; 800 nm to 1 μm; Or it may be 800 nm to 900 nm. By applying these fine particles, it is possible to provide a sufficient adsorption area for the functional ingredients of the shell layer and provide a UV blocking function.

According to one embodiment, the shell layer may further include an adhesion enhancer. The adhesion enhancer includes polyether-1, and the adhesion enhancer may be mixed with polyol. The polyol is at least one of propylene glycol, butylene glycol, dipropylene glycol, propanediol, tripropylene glycol, glycerin, diglycerin, polyglycerin, or 2,3-butanediol. It may include the above or a combination thereof. The adhesion promoter to polyol may be 1:10 to 20 (w/w). It may be included in an amount of 0.1 to 15 parts by weight per 100 parts by weight of the organic material of the shell layer. By applying the above range, the shell layer can be stably attached or coated on the core.

According to one embodiment, the shell layer may further include 4-ethoxybenzaldehyde, 4-methoxybenzaldehyde, or both. These may be included in an amount of 0.1 to 15 parts by weight per 100 parts by weight of the organic material of the shell layer.

According to one embodiment, the composite particles may be micro or nanoparticles to improve the dispersibility, solubility (e.g. cleaning), or function of a functional material or active ingredient in a formulation or solvent, for example, 300 nm to 800 μm (micrometer); 1 μm (micrometer) to 700 μm (micrometer); 5 μm (micrometer) to 600 μm (micrometer); 10 μm (micrometer) to 500 μm (micrometer); 10 μm (micrometer) to 800 μm (micrometer); 20 μm (micrometer) to 500 μm (micrometer); or 100 μm (micrometer) to 200 μm (micrometer).

According to one embodiment, the thickness of the shell is 0.1 ㎛ (micrometer) to 200 ㎛ (micrometer); 0.5 μm (micrometer) to 200 μm (micrometer); 1 μm (micrometer) to 150 μm (micrometer); 1 μm (micrometer) to 100 μm (micrometer); 10 μm (micrometer) to 50 μm (micrometer); 2 μm (micrometer) to 200 μm (micrometer); or 5 μm (micrometers) to 80 μm (micrometers). Here, the thickness of the shell may be the total size of the composite particle minus the thickness of the core and hydrogel layer.

According to one embodiment, the thickness of the hydrogel layer is 0.3 ㎛ (micrometer) to 300 ㎛ (micrometer); 0.5 μm (micrometer) to 200 μm (micrometer); 1 μm (micrometer) to 100 μm (micrometer); 1 μm (micrometer) to 50 μm (micrometer); 1 μm (micrometer) to 30 μm (micrometer); 1 μm (micrometer) to 10 μm (micrometer); 2 μm (micrometer) to 20 μm (micrometer); or 5 μm (micrometers) to 10 μm (micrometers). Here, the thickness of the shell may be the total size of the composite particle minus the thickness of the core and shell layers. The thickness of the hydrogel layer can provide sustainability or continuity of release of organic materials, functional materials, etc. of the shell layer.

According to one embodiment, the composite particle may further include an ionic compound and a functional material that can provide functions such as wrinkle improvement, whitening, and elasticity. According to one embodiment, the ionic compound and the functional material may each be included in an amount of 0.01% to 2% by weight of the composite particle.

According to one embodiment, the core, shell layer, or hydrogel layer, or all of them, includes at least one or a combination of titanium ions, silicon ions, magnesium ions, calcium ions, potassium ions, zinc ions, silver ions, or iron ions. an ionic compound; and at least one or a combination of a chelating agent, vitamin C, aloe gel, vitamin B3 (niacinamide), xyliton, retinol, Cordyceps sinensis, or squalene, or a combination thereof. In other words, the ionic compound allows the active ingredient to be stably maintained within the composite particle, improves the structural stability of the hydrogel or non-crosslinked hydrogel, or allows the components of the shell layer to bond well with the hydrogel (or non-crosslinked hydrogel). You can lose.

According to one embodiment, the ionic compound is applied as a salt of an ion (sulfate salt, halogen salt, carbonate, phosphate, organic acid salt, ammonium salt, etc.) and increases the bonding of the core and shell layers or disperses in a solvent or formulation. It can be further improved or cleaned better with a cleaning solution. For example, CaCO ₃ , CaHPO ₄ , Ca ₃ (PO ₄ ) ₂ , Ca(H ₂ PO ₄ ) ₂ , CaSO ₄ , CaSO ₃ , Ca(HSO ₄ ) ₂ , MgCO ₃ , MgHPO ₄ , Mg ₃ (PO ₄ ) ₂ , Mg(H ₂ PO ₄ ) ₂ , Ag ₂ CO ₃ , Ag ₃ PO ₄ , Ag ₂ HPO ₄ , AgH ₂ PO ₄ , Ag ₂ SO ₄ , Ag ₂ SO ₃ , and AgHSO ₄ , Cu ₃ ( It may be PO ₄ ) ₂ , CuHPO ₄ , CuCO ₃ , FeCO ₃ , Fe ³ (PO ₄ ) ₂ , FeHPO ₄ , etc.

According to one embodiment, the hydrogel layer surrounds the shell layer or is partially impregnated within the shell layer, and may protect the shell layer or effectively express a function in the target of application of the composite particle. In addition, the shell layer can be decomposed on the application object while preventing loss of the shell layer so that it can be safely delivered to the application object. The hydrogel layer includes a non-crosslinked hydrogel, and the hydrogel layer includes a hydrogel that is the same as or different from the core, and may only be in a non-crosslinked form. The hydrogel layer may further include a hydrogel with a lower degree of crosslinking than the core. The hydrogel layer may be a gel-type material in which no cross-linking agent is added or a cross-linking step is not performed in the production of the core hydrogel. According to one embodiment, the hydrogel layer may be 1% to 30% by weight of the composite particle.

According to one embodiment, the core and the hydrogel layer each have a thickness of 1 nm to 500 nm; 10 nm to 500 nm; 50 nm to 500 nm; Alternatively, it may be porous with pores of 100 nm to 300 nm. It mixes well with solvents and additives within the formulation, and the functional material can be sufficiently delivered to the application target through these pores.

According to one embodiment, the composite particles are tubes, fibers, oval-shaped, plate-shaped or spherical particles, and the size of the composite particles may be nano- or micro-sized, for example, 0.3 ㎛ to 800 ㎛; 10 μm to 800 μm; 0.6 μm to 600 μm; 0.8 μm to 500 μm; 1 μm to 400 μm; Or it may be 10 ㎛ to 200 ㎛.

According to one embodiment, the composite particles may appropriately utilize coating or encapsulation processes known in the technical field of the present invention, and are not specifically mentioned in this document. For example, spray drying or spray coating, emulsion process, mixing, drying, etc. may be used, but are not limited thereto.

According to one embodiment, the composite particles are present in an amount of 1% to 50% by weight of the cosmetic composition; 1% to 40% by weight; 1% to 30% by weight; 1% to 10% by weight; or 1% to 5% by weight; may include. The cosmetic composition may be in the form of liquid, aerosol, gel, suspension, emulsion, semi-solid or powder, and can provide skin regeneration and soothing functions. For example, it may be a lotion, cream, toner, spray, gel, balm, powder, suspension, emulsion, wax, etc. According to one embodiment, the cosmetic composition may apply appropriate carriers, additives, solvents, etc. depending on product function, formulation, application field, etc. This can only apply what is known in the technical field of the present invention, and is not specifically mentioned in this specification.

According to one embodiment, the cosmetic composition includes a phase change material including at least one of xanthan gum, gelatin, sodium alginate, pectin, carrageenan, and guar gum, or a combination or combination thereof; and ethanol, butanol, dipropylene glycol, erythritol, sorbitol, glycerol, propanediol, 1,3-butylene glycol, diethylene glycol, and isopentyldiol. Together with the composite particles, they can provide a cooling function (e.g. after storage at room temperature or cold temperature). These may each be 0.001% to 5% by weight of the cosmetic composition. By applying the mentioned content range, it is possible to provide skin soothing and skin protection functions by cooling function and to maintain the formulation of the cosmetic composition stably.

According to one embodiment, the cosmetic composition includes extracts for skin soothing of Japanese knotweed root extract, goldenrod extract, green tea extract, Spanish licorice root extract, Matricaria flower extract, rosemary leaf extract, portulaca quince extract, or grapefruit extract. It can be included. They may be included in 0.1% to 5% by weight of the cosmetic composition.

According to one embodiment, the cosmetic composition may include ingredients with moisturizing activity, such as hollyhock root extract, hydroxyethyl urea, or trehalose. They may be included in 0.1% to 5% by weight of the cosmetic composition.

According to one embodiment, the extract mentioned in the cosmetic composition may be extracted by standard or known methods, for example, hot water extraction, cold immersion extraction, reflux cooling extraction, solvent extraction, steam distillation, ultrasonic extraction, and elution method. , compression method, etc. can be used.

The cosmetic composition of the present invention may contain appropriate ingredients depending on the formulation, for example, preservatives, neutralizers, colorants, oils, fatty acids, purified water, synthetic wax, bead wax, thickeners, aqueous ingredients, oil-based ingredients, powder ingredients. , alcohols, moisturizers, thickeners, ultraviolet absorbers, whiteners, preservatives, antioxidants, surfactants, fragrances, colorants, various skin nutrients, spherical silicone-based powders, or combinations thereof, may be appropriately mixed according to need, and are limited thereto. It doesn't work. For example, they may each be 0.001% to 80% by weight of the cosmetic composition. For example, the thickener is carbomer, ammonium acryloyl dimethyl taurate, ammonium acryloyl dimethyl taurate BP copolymer, sodium polyacrylate acrylate copolymer, polyacrylate crosspolymer-6, acrylate. /C10-30 Alkyl acrylate crosspolymer, disteadimonium hectorite, stearalkonium hectorite, stearalkonium bentonite, xanthan gum, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyl It may include propylmethylcellulose, stearoxy ether, etc.

For example, the preservative may include pentylene glycol, glyceryl caprylate, ethylhexyl glycerin, caprylyl glycol, phenoxyethanol, hydroxyacetophenone, 1,2-hexanediol, etc., The neutralizing agent may include tromethamine, triethanolamine, imidazolidinyl urea, etc. For example, the oil includes octyldodecanol, dicaprylyl carbonate, ethylhexylneopentanoate, ethylhexylisononanoate, ethyllaurate, butyllaurate, ethylhexylmyristate, isopropylmyristate, Octyldodecyl myristate, ethylhexyl oleate, ethylhexyl palmitate, isopropyl palmitate, ethylhexyl isopalmitate, ethylhexyl stearate, ethylhexyl isostearate, isononyl isononanoate, polyglyceryl- 2Triisostearate, pentaerythrityl tetraisostearate, cetyl ethylhexanoate, diisostearyl maleate, phytosteryl isostearyl dimerinolyate, cyclopentasiloxane, cyclohexasiloxane, dime It may include thicone, phenyltrimethicone, caprylylmethicone, disiloxane, etc.

For example, the fatty acids may include stearic acid, palmitic acid, myristic acid, isostearic acid, behenic acid, etc.

For example, the silicone-based powder includes methyl methacrylate cross polymer, polymethylsilsesquioxane, vinyldimethicone-methicone silsesquioxane crosspolymer, and diphenyldimethicone-vinyldiphenyldimethicone-silsesquioxane. It may include cross polymers, etc.

In addition, for example, metal sequestrants such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid, caffeine, tannin, belafamil, licorice extract, glablidin, and calin. Hot water extract of fruits, various herbal medicines, tocopherol acetate, glythylitic acid, tranexamic acid, vitamin C, magnesium ascorbate phosphate, ascorbate glucoside, arbutin, kojic acid, glucose, fructose, trehalose and other sugars. Additives may be included, but are not limited thereto.

For example, oils for skin protection may include, but are not limited to, hydrolyzed pea protein, shea butter, castor oil, hydrogenated castor oil, jojoba seed oil, argan kernel oil, and olive oil. .

According to one embodiment, the cosmetic composition can be applied to all external organs of the human body (skin or hair), skin (face, hands, arms, legs, feet, chest, stomach, back, buttocks, scalp), hairline. , eyebrows, hair, fingernails, toenails, mucous membranes, etc., and can provide skin regeneration and soothing effects.

According to one embodiment, the cosmetic composition may be skin-based cosmetics such as lotion, cream, skin, mist, spray, essence, primer, etc., but is not limited thereto.

According to one embodiment, the cosmetic composition may be a makeup product applied to lips, eyes, skin (e.g., face), hands/toenails, body, etc., and may include, for example, color products (e.g., lipstick, eyes, face, etc.), and more specifically, it may be lip balm, lip glow, eye shadow, eyebrow, mascara, cream or liquid foundation, powder, etc., but is not limited thereto.

According to one embodiment, the cosmetic composition may be applied to the skin, scalp, etc. According to one embodiment, the cosmetic composition may be skin basic cosmetics such as lotion, cream, skin, mist, spray, essence, primer, pack, etc., but is not limited thereto. For example, the cosmetic composition may be used in the form of a stick balm, lotion, powder, cream, or ampoule, or may be impregnated or coated on a sheet, film, etc. According to one embodiment, the cosmetic composition may provide a cooling effect to soothe the skin after being stored at room temperature or low temperature.

According to one embodiment, the cosmetic composition may be applied to the skin after a skin procedure or skin treatment to protect the skin and provide a regenerative function. For example, the skin procedure may be a tattoo procedure (eg, eyebrows), tattoo removal procedure, dermabrasion, radiofrequency irradiation, laser irradiation, LED irradiation, etc. Alternatively, it may be applied to irritated or damaged skin after waxing (arms, legs, scalp, hands, armpits, etc.).

Hereinafter, the present invention will be described in more detail through examples and comparative examples. However, the following examples are only for illustrating the present invention, and the content of the present invention is not limited to the following examples.

Example 1

Preparation of hydrogel

Sodium hyaluronate 360 kDa (molecular weight range 240-490 kDa) was dissolved in 200 mM sodium phosphate dibasic dodecahydrate buffer solution to a concentration of 10% (w/v) and stirred on a heat shaker at 65°C for 1 hour. A hydrogel was prepared by stirring at room temperature for 1 hour. Sodium dodecylbenzenesulfonate (SDBS) and cocoyl hydroxyethylimidazolinium lauryl/myristril trimethyl ammonium methosulfate (1:1 w/w) were dissolved in deionized water and heated to 34 °C. Sodium dodecylbenzenesulfonate (SDBS) and cocoyl hydroxyethylimidazolinium lauryl/myristril trimethyl ammonium methosulfate (15 parts by weight for 100 parts by weight of hydrogel), prepared hydrogel and crosslinking agent ( 1,4-Butanediol diglycidyl ether (0.01 parts by weight based on 100 parts by weight of the hydrogel) was mixed and ultrasonic stirred for 5 hours, followed by ultrasonic spraying to crosslink and dry at 50°C. The prepared cross-linked hyaluronic acid hydrogel was washed with purified water or physiological saline to remove residual cross-linking agent. The crosslinking degree of the prepared crosslinked hyaluronic acid hydrogel was measured by H-NMR analysis (nuclear magnetic resonance spectroscopy), and the crosslinking degree was about 20%.

Cica components (Madecassoside, Asiaticoside = 1:1 mass ratio), chitosan (molecular weight: 3,000 (Da), DA: 95 %, powder particles: 0.7 ㎛), ceramide, panthenol and sodium poly Acrylate starch is dispersed in purified water and polyether-1/polyol (1:2 w/w) (3 parts by weight based on 100 parts by weight of organic material), and if necessary, ethanol (organic solvent for dispersion) or a small amount of An organic material coating solution (concentration 50%) was prepared by adding a surfactant. The mixing ratio of the cica component, chitosan, ceramide, panthenol, and sodium polyacrylate starch is 1:0.8:0.9:1:0.8 (w/w).

Next, the crosslinked hydrogel particles were mixed in an organic material coating solution to form a shell layer and dried (if necessary, dried using ultrasonic spraying or freeze-dried). Next, the same hydrogel (non-crosslinked state, i.e., hydrogel before adding a crosslinking agent) was added to the solution and stirred to form composite particles having a core/shell (10% by weight)/hydrogel layer (10% by weight) (using ultrasonic waves if necessary). After using, drying or freeze-drying) was prepared.

Example 2

Chitosan (400 kDa) was dissolved using 100 mM acetic acid. Sodium hyaluronate 360 kDa (molecular weight range 240-490 kDa) was dissolved in 200 mM sodium phosphate dibasic dodecahydrate buffer solution to a concentration of 10% (w/v). At this time, it was dissolved for 30 minutes using a thermal stirrer at 40°C, and then cooled to room temperature while stirring with a stirrer. If necessary, more NaOH can be added. The chitosan solution and the hyaluronic acid solution were mixed, stirred for 1 hour on a heat stirrer at 65°C, and stirred for 1 hour at room temperature to prepare a hydrogel (0.5 to 0.8 molar ratio of chitosan-modified hyaluronic acid hydrogel). Sodium dodecylbenzenesulfonate (SDBS) and cocoyl hydroxyethylimidazolinium lauryl/myristril trimethyl ammonium methosulfate (1:1 w/w) were dissolved in deionized water and heated to 34 °C. Sodium dodecylbenzenesulfonate (SDBS) (15 parts by weight based on 100 parts by weight of hydrogel), hydrogel and crosslinking agent (1,4-butanediol diglycidyl ether, 0.01 part by weight based on 100 parts by weight of hydrogel) were mixed and stirred ultrasonically for 5 hours, followed by ultrasonic spraying and crosslinking and drying at 50°C. The degree of crosslinking was measured by H-NMR analysis (nuclear magnetic resonance spectroscopy), and the degree of crosslinking was about 19%.

Next, the crosslinked hydrogel particles were mixed in an organic material coating solution (same as Example 1) to form a shell layer and dried (if necessary, dried using ultrasonic spraying or freeze-dried). Next, it was added to the same hydrogel (non-crosslinked state) solution and stirred to produce composite particles (if necessary, dried or freeze-dried using ultrasonic spraying) having a core/shell (10% by weight)/hydrogel layer (10% by weight). Manufactured.

Comparison example 1

The core was prepared in the same manner as in Example 1, except that the non-crosslinked hydrogel of Example 1 (before cross-linking agent was added) was used.

As shown in Table 1 below, a cosmetic composition (cream) having a skin regeneration function including Example 1, Example 2, and Comparative Example 1 was prepared.

ingredient (weight%) Purified water 50 Palmitic Acid 10 glycerin 2.5 ethanol 2.5 Pentylene glycol One synthetic wax 2.3 caprylyl glycol 0.2 carbomer 0.5 Butylene glycol 3 Polymethylsilsesquioxane 8 composite particles 20

Skin hypoallergenic performance

A patch containing the cosmetic composition containing the composite particles prepared according to the above examples and comparative examples as an active ingredient was prepared, and a primary human skin irritation test was performed using the patch for 48 hours. Specifically, a patch (2Х4 cm) containing the cosmetic composition prepared according to the Examples and Comparative Examples was manufactured, and the patch was applied closed to clinical subjects for 6 hours, and then the patch was removed. Then, after 24 hours, the area where the patch was attached was observed and the satisfaction scale was evaluated according to the evaluation criteria. At this time, a total of 20 people, 10 women and 10 men in their 10s to 50s, were selected as clinical subjects. The clinical subject was evaluated by attaching a patch to the treatment area immediately after performing a semi-permanent tattoo on the skin of the back. The evaluation criteria for skin irritation are as follows, and the results are shown in Table 2:

Non-irritant: Sensitization value 0.00 or more but less than 0.15

Mild irritation: Sensitization value 0.15 or more but less than 0.70

Moderate irritation: Sensitization value 0.70 or more but less than 1.00

Strong irritation: Sensitization value over 1.00

stimulation level Judgment Example 1 0.13 No stimulation Example 2 0.12 No stimulation Comparison example 1 0.9 medium irritation

It can be seen that the cosmetic composition using the composite particles according to the present invention has low skin irritation and is suitable for application after skin treatment.

skin regeneration performance

The effect of the composite particles prepared in Examples and Comparative Examples on skin regeneration performance was tested by measuring the proliferative ability of human fibroblasts, which are collagen-forming cells in the dermal layer of the skin. Specifically, human fibroblasts cultured in DMEM medium were seeded in a 96-well plate at 1Х10 ⁴ (cells/well) cells per well. Here, ascorbic acid (Dexamethason) (1000 ㎍/㎖) as a positive control and composite particles (1000 ㎍/㎖ purified water dilution) of Examples and Comparative Examples were added, respectively, and cultured for 72 hours. After culturing, the cells were treated with the Easytox kit reagent, which stains living cells. After 1 hour, the absorbance was measured at 450 nm using an ELISA reader to calculate the skin cell proliferation ability (i.e., the higher the absorbance, the better the proliferation ability), and the results are shown in Table 3 below.

Absorbance at 450 nm Positive control group 59.7% Example 1 64.0% Example 2 65.7% Comparison example 1 49.6%

It can be confirmed that the composite particles according to the present invention have excellent skin regeneration effect.

Evaluation of skin damage improvement efficacy

The clinical subjects consisted of 5 people per evaluation group, and the cream prepared in the Examples and Comparative Examples was applied to the affected area immediately after the laser treatment for tattoo removal. Clinical subjects were asked to apply the product to the treatment area twice a day for one week, and after using it for one week, they were evaluated on a 5-point satisfaction scale below (5 points for most satisfaction, 4 points for satisfaction, 3 points for average, 2 points for dissatisfaction, Very dissatisfied 1 point). The results are shown in Table 4.

Exfoliating skin improvement effect Itching improvement effect Skin erythema improvement effect Example 1 4.4 4.7 4.5 Example 2 4.2 4.5 4.4 Comparison example 1 3.0 3.8 3.3

It can be seen that the skin regeneration effect is the best after skin treatment when the skin regeneration cream according to the present invention is applied.

Evaluation of skin regeneration and skin improvement efficacy

Each evaluation group consisted of 10 women in their 30s to 50s with no current skin allergy symptoms, and the cream prepared in the examples and comparative examples was applied once daily for 8 weeks,

The skin condition was evaluated before use and after 8 weeks of use. The average value was calculated to evaluate the effect of skin elasticity improvement and skin renewal. The evaluation standard used a scale of 1 to 5 points, with skin condition in terms of skin moisturization, skin elasticity, and skin regeneration being 'very worsened' being given 1 point, 'slightly worsened' being given 2 points, and 'no change' being given 3 points. , ‘Slightly improved’ was given 4 points, and ‘Very improved’ was given 5 points. The results are shown in Table 5.

Example 1 Example 2 Comparison example 1 Skin moisturizing 4.5 4.8 3.5 skin elasticity 4.6 4.9 3.1 skin regeneration 4.6 4.7 3.2

It can be seen that when the skin regeneration cream according to the present invention is applied, the skin moisturizing, skin elasticity improvement, and skin regeneration effects are the most excellent.

As the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that these specific techniques are merely preferred embodiments and do not limit the scope of the present invention. something to do. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (21)

A core comprising a crosslinked hydrogel and an ionic surfactant;
A shell layer surrounding the core and containing an organic material including cica component, madecassoside, chitosan, ceramide, panthenol, and sodium polyacrylate starch; and
A hydrogel layer surrounding the shell layer;
Composite particles containing;
Including,
The cross-linked hydrogel of the core is,
At least one of 1,4-butanediol diglycidyl ether, and 1,2-ethanediol diglycidyl ether, or a combination thereof The hydrogel is cross-linked with a cross-linking agent containing,
Cosmetic composition for skin regeneration.
According to paragraph 1,
The cica component is 1% to 30% by weight of the organic material,
The cica component is at least one of Centella asiatica extract, Madecassoside, Asiaticoside, Madecassic acid, or Asiatic acid, or A cosmetic composition comprising a combination of these.

According to paragraph 1,
The chitosan is a low molecular weight chitosan of 5,000 to 10,000 daltons (Da),
The chitosan, ceramide, panthenol, and sodium polyacrylate starch are each contained in an amount of 1% to 20% by weight of the organic material.
◈Claim 4 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The shell layer is,
At least one or a combination of tocopheryl acetate, vinegar, and adenosine; It further includes, each of which is included in an amount of 10 to 20 parts by weight based on 100 parts by weight of the organic material,
Cosmetic composition.
◈Claim 5 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
In the crosslinked hydrogel, the hydrogel is,
A cosmetic comprising at least one of hyaluronic acid hydrogel, gelatin hydrogel, chitosan hydrogel, poly(ethylene glycol), poly(hydroxyethyl methacrylate)) or polyvinyl alcohol hydrogel, or a combination thereof. Composition.
delete delete delete delete ◈Claim 10 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The ionic surfactant is,
A cosmetic composition comprising 10 to 20 parts by weight based on 100 parts by weight of the hydrogel of the core.
◈Claim 11 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The ionic surfactant includes a cationic surfactant and an anionic surfactant,
The cationic surfactant is cocoyl hydroxyethylimidazolinium lauryl/myristril trimethyl ammonium methosulfate or cetyl trimethyl ammonium bromide,
The cosmetic composition wherein the anionic surfactant is sodium dodecyl sulfate, palmitate, or sodium dodecylbenzenesulfonate (SDBS).
◈Claim 12 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The core further includes a nonionic surfactant,
The nonionic surfactant is,
Polyglyceryl-3 polyricinoleate, polyglyceryl-2 sesquiisostearate, polyglyceryl-2 triisostearate, polyglyceryl-3 methyl glucose distearate, polyglyceryl-6 stearate, Contains at least one of polyglyceryl-6 behenate and polyglyceryl-6 polyricinoleate,
The nonionic surfactant is in an amount of 1 to 50 parts by weight based on 100 parts by weight of the ionic surfactant.
◈Claim 13 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The core is,
At least one or a combination of titanium ions, silicon ions, magnesium ions, calcium ions, potassium ions, zinc ions, or iron ions; and
At least one or a combination of chelating agent, vitamin C, aloe gel, vitamin B1, xylitol, retinol, Cordyceps sinensis or squalene;
A cosmetic composition further comprising:
◈Claim 14 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The shell layer is,
inorganic oxide-based particles; It further includes,
The inorganic oxide-based particles are contained in a mass ratio (w/w) of 0.5 to 5 with respect to the organic material,
The inorganic oxide particles are,
A cosmetic composition comprising at least one of silica, zinc oxide, titanium oxide, kaolin, magnesium oxide, iron oxide, or a combination thereof.
◈Claim 15 was abandoned upon payment of the setup registration fee.◈ According to clause 14,
A cosmetic composition in which the size of the inorganic oxide-based particles is 500 nm to 10 ㎛.
◈Claim 16 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The composite particles are,
It is a plate-shaped or spherical particle,
A cosmetic composition in which the size of the composite particles is 10 ㎛ to 800 ㎛.
◈Claim 17 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The cosmetic composition wherein the core and the hydrogel layer are each porous with pores of 50 nm to 500 nm.
delete ◈Claim 19 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The shell layer is an adhesion enhancer
A cosmetic composition further comprising:
◈Claim 20 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The cosmetic composition is a balm, lotion, powder, cream or ampoule in the form of a stick.
◈Claim 21 was abandoned upon payment of the setup registration fee.◈ According to paragraph 1,
The cosmetic composition is,
A cosmetic composition to be applied to the skin after a tattoo procedure or after tattoo removal.