KR20190001136A

KR20190001136A - Composition of face-lifting pack for improving skin condition comprising oligopeptides

Info

Publication number: KR20190001136A
Application number: KR1020170080657A
Authority: KR
Inventors: 고창보; 박희섭; 성민주; 정민지; 최창섭; 제이미 김; 윌리엄 첸
Original assignee: 주식회사 엔씨엘바이오; 보니 ＆ 클라우스 인크.
Priority date: 2017-06-26
Filing date: 2017-06-26
Publication date: 2019-01-04

Abstract

Disclosed herein is a cosmetic composition for improving the skin condition containing an oligopeptide-containing peptide as an active ingredient. The cosmetic composition for improving skin condition, which is one aspect of the present invention, can effectively transmit the effect inherent in an active ingredient, particularly a peptide, to the skin. Accordingly, the cosmetic composition according to one aspect of the present invention can provide a skin wrinkle improvement, a skin elasticity improvement, a skin tone improvement and a skin whitening effect to a user while containing a small amount of peptides, and can be used as a pack cosmetic for skin lifting It is worth using. In addition, since the composition has a short drying time after application to the skin, the skin lifting effect can be maximized and the cleaning ability after use is also excellent.

Description

Technical Field [0001] The present invention relates to a skin improving lifting pack composition containing an oligopeptide,

Disclosed herein is a cosmetic composition for improving the skin condition containing an oligopeptide-containing peptide as an active ingredient.

The human skin is aged due to external factors such as ultraviolet rays and internal factors such as a decrease in cell function. As skin aging progresses, the thickness of the epidermis, dermis, and subcutaneous tissue becomes thinner and the ECM (Extracellular matrix) component that gives skin elasticity changes. Among them, collagen which accounts for 70 ~ 80% The skin aging phenomenon such as skin sagging, loss of elasticity and wrinkles of the skin occurs.

In recent years, as consumers have become more interested in skin beauty, there are a growing number of people seeking to delay the aging of skin by injecting fillers, collagen injections, or wrinkle lifting in medical institutions. However, in general, procedures performed in a medical institution are carried out by injecting a specific component into the skin. It is troublesome to receive a procedure, expensive to be effective, and free from the problem of side effects There was a limitation that it could not be done.

Recently, the needs of consumers for cosmetics that can be easily used and can be improved at a low price compared to the existing medical institutions are increasing explosively.

On the other hand, peptides are attracting attention as a substance derived from a human body and having no toxicity to the human body and excellent in skin condition improving effect, and researches for introducing them into a cosmetic composition are actively conducted. However, a cosmetic composition capable of effectively transferring the skin condition-improving effect inherent in the peptides to the skin has not been developed yet, and most of them contain a high content of peptides and little effect on skin condition improvement.

KR 10-2016-0143017A

In one aspect, an object of the present invention is to provide a cosmetic composition capable of effectively delivering the efficacy of peptides, especially oligopeptides, to the skin.

In one aspect, an object of the present invention is to provide a cosmetic composition which is superior in skin wrinkle, skin elasticity improvement, skin tone improvement, and skin whitening effect.

In one aspect, the present invention provides a cosmetic composition for improving skin condition, wherein the composition comprises 10 ^-6 to 10 ^-1 % by weight of peptides, based on the total weight of the composition; 10 ^-2 to 10 ^-1 % by weight of a compound of a base and a pentasaccharide; And 10 < ^-1 > to 5x10 < ^-1 > wt% of an acidic substance, wherein the pH of the composition is 4 to 5.

The cosmetic composition for improving the skin condition, which is one aspect of the present invention, can effectively transmit the effect inherent in the active ingredient, particularly the peptide, to the skin. Accordingly, the cosmetic composition according to one aspect of the present invention can impart excellent skin wrinkles, skin elasticity improvement, skin tone improvement and skin whitening effect to a user while containing a small amount of peptides, As a result, In addition, the composition can maximize the skin lifting effect by shortening the drying time after application to the skin, and is excellent in washing power after use, so that there is no tackiness after use and a refreshing feeling can be given.

FIG. 1 shows a change in the skin condition of a user using the cosmetic composition according to one aspect of the present invention.

Hereinafter, the present invention will be described in detail.

In one aspect, the present invention provides a cosmetic composition for improving skin condition, wherein the composition comprises 10 ^-6 to 10 ^-1 % by weight of peptides based on the total weight of the composition; 10 ^-2 to 10 ^-1 % by weight of a compound of a base and a pentasaccharide; And 10 < ^-1 > to 5x10 < ^-1 > wt% of an acidic substance, wherein the pH of the composition is 4-5.

As used herein, the term " compound " may mean a substance produced through the combination of two or more kinds of atoms.

The composition according to one aspect of the present invention can exhibit an excellent skin condition improving effect in the pH range.

In this respect, the pH of the composition can be from 4 to 5, and preferably from 4.5 to 4.8. When the pH of the composition is 4 to 5, a superior skin condition improving effect can be obtained. That is, even when a very small amount of peptides is contained in the above pH range, it can exhibit a remarkably excellent skin condition improving effect as compared with the case where the peptides are over 1% by weight at a pH out of the above range.

In one aspect, the oligopeptides of the peptides may be included in an amount of 10 ^-6 to 10 ^-4 % by weight, based on the total weight of the composition.

In this aspect, the peptides may be oligopeptides; And at least one selected from the group consisting of hexapeptides, tripeptides, tetrapeptides and polylysine.

In one aspect, an excellent skin condition improving effect can be obtained by using, in combination, at least one selected from the group consisting of hexapeptide, tripeptide, tetrapeptide and polylysine in addition to the oligopeptide.

The oligopeptide may include an Al-Oleo peptide-1, also called an epidermal growth factor (EGF).

In addition, the hexapeptide may comprise an acetylhexapeptide, and in one embodiment may be acetylhexapeptide-8.

The tripeptide may comprise a capper tripeptide, and in one embodiment, may be capper tripeptide-1.

In addition, the tetrapeptide may include tetrapeptide-21.

In this aspect, the base may comprise a purine base, and the pentose may be xylose, arabinose, ribose, or ribulose. In one embodiment, the compound of the base and pentasaccharide may comprise adenosine as a compound of purine and ribose.

In one embodiment, the acidic material may comprise citric acid. The acidic substance may include, but is not limited to, an organic acid such as malic acid, succinic acid, tartaric acid, etc. However, when citric acid is contained in the composition, the best skin improving effect can be obtained.

In addition, in the above aspect, the composition may comprise 1 to 3% by weight of an increasing agent based on the total weight of the composition; And 5 to 10% by weight of the film former.

In one embodiment, the builder may comprise a carbomer. When the cosmetic composition is applied to the skin, the drying time is fastest and the skin lifting effect is excellent even when the cosmetic composition is applied to the skin. . In the present specification, the skin lifting effect may mean an effect of stretching and stiffening the stretched and stretched skin due to aging and the like.

The thickener may be contained in an amount of 1 to 3% by weight, preferably 1.5 to 2.5% by weight based on the total weight of the composition. If the content of the thickening agent exceeds 3% by weight, the skin-releasing property is deteriorated. If the content of the thickening agent is less than 1% by weight, a problem of flowing down from the skin occurs during application.

In addition, in one aspect, the composition may further comprise at least one plant extract selected from the group consisting of green tea extract, lotus seed extract and marigold extract. In one embodiment, the composition may include both green tea extract, lotus seed extract, and marigold extract, and at this time, a superior skin condition improving effect can be obtained as compared with the case of not including them.

In this specification, the term 'extract' includes all substances obtained by extracting the components of a natural product, regardless of the extraction method, extraction solvent, extracted components or extracts, and further extracts a substance obtained from the natural product, Is a broad concept that encompasses all materials that can be obtained by processing or processing in other ways. In one aspect of the present disclosure, the plant extract comprises washing and drying the plant; Solvent extraction of the dry plant; And filtering the extracted plants. The solvent includes at least one selected from the group consisting of water, an organic solvent, and a mixture of water and an organic solvent. Wherein the water comprises distilled water or purified water and the organic solvent is selected from the group consisting of alcohol, acetone, ether, ethyl acetate, diethyl ether, ethyl methyl ketone and chloroform, examples being C ₁ -C _{5 lower} carbon alcohols But is not limited thereto.

In one embodiment, the plant extract may comprise from 0.1 to 10% by weight, based on the total weight of the composition. Specifically, the green tea extract may be contained in an amount of 1 to 7% by weight, preferably 4 to 6% by weight, and the lotus seed extract is contained in an amount of 0.1 to 3% by weight, preferably 0.1 to 1.5% by weight The extract may be contained in an amount of 1 to 3% by weight, preferably 1.5 to 2% by weight.

In one embodiment, the film former may comprise a combination of polyurethane and polymethyl methacrylate. The polyurethane may include polyurethane-2.

In the above aspect, the composition may be for preventing or improving wrinkles, for whitening skin, for improving skin tone, or for improving skin elasticity.

In the present specification, improvement of skin tone may mean improvement of darkening of skin tone due to deposition of melanin pigment in the skin or the like.

In one aspect, the composition may be a packaged cosmetic composition. The packaged cosmetic composition according to one aspect of the present invention has a short time required for drying such as drying within 15 minutes after application of the skin, so that it is easy to use and maximized skin lifting effect can be obtained.

The cosmetic compositions according to the present disclosure can be provided in all formulations suitable for topical application. For example, it may be provided as a formulation of an emulsion obtained by dispersing an oil phase in an aqueous solution, an emulsion obtained by dispersing an oil phase in water, a suspension, a solid, a gel, a powder, a paste, a micro needle, a foam or an aerosol composition . Compositions of such formulations may be prepared according to conventional methods in the art.

The cosmetic composition according to the present invention may further comprise ingredients included in the functional ingredients and general cosmetic compositions in addition to the above ingredients. The functional additives may include water-soluble vitamins, oil-soluble vitamins, polymeric polysaccharides, sphingolipids, and the like.

The cosmetic composition according to the present invention may contain, in addition to the above-mentioned components, other ingredients which can give a synergistic effect to the main effect, preferably to the extent that the main effect of the composition of the present invention is not impaired. The cosmetic composition according to the present invention may further comprise a moisturizer, an emollient, a surfactant, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a pH adjuster, an organic and inorganic pigment, a fragrance, a cold agent or a limiting agent. The compounding amount of the above components can be easily selected by those skilled in the art within a range not to impair the objects and effects of the present invention.

Hereinafter, the present specification will be described in detail with reference to the production examples, examples, comparative examples and test examples of the present specification. They are offered by way of illustration only, and are not intended to limit the scope of the present disclosure to these examples, comparative examples and test examples.

[Production Example] Preparation of cosmetic composition

A cosmetic composition was prepared using Composition A shown in Table 1 below and Composition B shown in Table 2.

[Preparation Example 1] Preparation of Composition A

Carbohydrates, adenosine and p-anionic alcohols were added to purified water at 75 占 폚, mixed with a disperser at 1,500 rpm for 30 minutes, cooled to 30, dissolved in 7% of glycerin, Hexapeptide-8, capper tripeptide-1, tetrapeptide-21, and phenoxyethanol, caprylic glycol, lotus seed extract and citric acid were added and mixed for 30 minutes at 1,500 rpm with a Dispermixer. After cooling, the composition A was prepared as shown in Table 1.

Raw material name Sample 1 Al-H-oligopeptide-1 0.00001g Acetyl hexapeptide-8 0.01 g Copper tripeptide-1 0.01 g Tetrapeptide-21 0.01 g Adenosine 0.04 g Carbomer 2.0 g glycerin 7.0 g Citric acid 0.2 g Phenoxyethanol 0.3 g Caprylic glycol 0.3 g p-no formula 0.01 g Green tea extract 3g Lotus seed extract 1g Purified water 86.11999g total 100g

[Preparation Example 2] Preparation of Composition B

Niacin amide was added to the purified water and dissolved at 1,500 rpm using a disper mixer. Polyurethane-2 / polymethyl methacrylate, polylysine, green tea extract, and mashii extract were sequentially added and mixed at 1,500 rpm for 10 minutes To prepare Composition B of Table 2.

Raw material name Sample 5 Polyurethane-2 / Polymethyl methacrylate 50g Polylysine 0.01 g Niacinamide 2g Green tea extract 2g Marchia extract 2g Purified water 43.99g total 100g

[Preparation Example 3] Preparation of cosmetic composition

The composition A and the composition B were mixed at a weight ratio of 6: 1.1, respectively, to prepare the cosmetic composition of the present invention. Hereinafter, the prepared cosmetic composition is referred to as Example 1. The pH of the composition of Example 1 was about 4.8.

[Experimental Example] Effect of improving skin condition and cleaning power of cosmetic composition

[Experimental Example 1] Evaluation of effect of composition on pH

The composition of Example 1 was uniformly applied to the faces of 20 male and female subjects uniformly and evaluated for drying time, skin lifting effect, wrinkle improving effect, skin tone improvement, skin whitening effect and washing power. Further, the same experiment was conducted with the compositions (Comparative Examples 1 to 4, respectively) in which the pH of the composition of Example 1 was adjusted to 3.8, 5.2, 6,

The results were as follows: 1 point for "very dissatisfied", 2 points for "dissatisfied", 3 points for "normal", 4 points for "satisfaction" and 5 points for "very satisfied" for skin lifting effect, wrinkle improvement effect, Table 3 summarizes the scores of the subjects by item and the average value divided by the number of subjects.

The skin lifting effect, the wrinkle improving effect, the skin whitening effect, and the skin tone improving effect were evaluated after using the cosmetic composition twice a week for 4 weeks.

The cleansing power was evaluated by whether or not there was a foreign sensation such as a sticky feeling after washing with a cleansing foam.

The drying time was measured based on the time when the gel was formed on the skin.

Skin lifting effect Wrinkle improvement effect Skin tone improvement effect Skin whitening effect Cleaning power Drying time Example 1 4.8 4.7 4.4 4.2 4.5 About 15 minutes Comparative Example 1 3.2 3.0 2.8 3.0 3.7 Approximately 23 minutes Comparative Example 2 3.1 3.0 2.5 3.0 2.8 About 25 minutes Comparative Example 3 2.8 2.7 3.0 2.8 2.8 About 25 minutes Comparative Example 4 2.5 2.5 2.8 2.7 2.5 About 27 minutes

As a result, it was confirmed that when the composition of the present invention (Example 1) was applied, excellent skin wrinkle improving effect and skin lifting effect were obtained and skin whitening effect and tone improving effect were excellent (Table 3 and Fig. 1) , And the cleaning power after use was also excellent. On the other hand, when the pH is out of the range of 4 ~ 5, the skin condition improvement effect is not good and the washing power after use is also decreased.

[Experimental Example 2] Confirmation of effects of plant extracts in compositions

A cosmetic composition was prepared in the same manner as in Example 1 except that no plant extract was added as compared with Example 1 (Comparative Example 5), and skin lifting effect, skin wrinkle reducing effect and the like were evaluated in the same manner as above , And the results are shown in Table 4.

Skin lifting effect wrinkle improvement
effect Skin tone improvement effect Skin whitening effect Example 1 4.8 4.7 4.4 4.2 Comparative Example 5 4.0 4.0 3.7 3.5

From the results of Table 4, it was confirmed that the effect of improving the skin condition was less than that of the case of containing the plant extract (Example 1) in the case of not containing the plant extract (Comparative Example 5).

[Experimental Example 3] Determination of washing power, drying time and skin lifting effect according to the incremental agent

A cosmetic composition was prepared in the same manner as in Example 1 (Comparative Examples 6 to 8, respectively), except that the thickening agent was used in place of carbohydrate in the composition of Example 1 as strorrhythmia, carrageenan powder or gellan gum. Table 5 shows the cleaning power, drying time and skin lifting effect for each composition.

Cleaning power Drying time Skin lifting effect Example 1 4.5 About 15 minutes 4.8 Comparative Example 6 3.0 About 27 minutes 4.3 Comparative Example 7 3.1 About 26 minutes 3.9 Comparative Example 8 2.8 About 30 minutes 3.9

As a result, it was found that the cleaning power and the skin lifting effect were lowered and the drying time was greatly increased when a thickening agent other than carbomer was used.

Claims

A cosmetic composition for improving skin condition,
The composition, based on the total weight of the composition,
10 ^-6 to 10 ^-1 % by weight of peptides;
10 ^-2 to 10 ^-1 % by weight of a compound of a base and a pentasaccharide; And
10 < ^-1 > to 5 x 10 < ^-1 > wt%
Wherein the pH of the composition is 4 to 5.

The method according to claim 1,
The above-
Oligopeptides; And
A peptide, a peptide, a peptide, a tetrapeptide, and a polylysine.

The method according to claim 1,
Wherein the compound of the base and the pentasaccharide comprises adenosine.

The method according to claim 1,
Wherein the acidic substance comprises citric acid.

The method according to claim 1,
The composition, based on the total weight of the composition,
1 to 3% by weight of an increasing agent; And 5 to 10% by weight of a film-forming agent.

The method according to claim 1,
Wherein the composition further comprises at least one plant extract selected from the group consisting of green tea extract, lotus seed extract and marigold extract.

3. The method of claim 2,
The above-
10 ^-6 to 10 ^-4 % by weight of an oligopeptide.

6. The method of claim 5,
Wherein the thickener comprises a carbomer,
Wherein the film-forming agent comprises a combination of polyurethane and polymethyl methacrylate.

The method according to claim 6,
Wherein the plant extract is contained in an amount of 0.1 to 10% by weight based on the total weight of the composition.

10. The method according to any one of claims 1 to 9,
The composition may comprise,
A cosmetic composition for improving skin condition, for preventing or improving wrinkles of skin, for whitening skin, for improving skin tone, or for improving skin elasticity.

10. The method according to any one of claims 1 to 9,
Wherein said composition is in the form of a pack.