KR101865841B1 - Cosmetic composition for improving skin wrinkle using nano capsule method with excellent skin permeability and stability - Google Patents

Abstract

Disclosed is a cosmetic composition for reducing skin wrinkles prepared by using a technology of a nano-capsule with excellent skin-permeability and stability wherein active ingredients permeate a deep portion of skin and can promote effects of reducing skin wrinkles and improving whitening. According to the present invention, the cosmetic composition for reducing skin wrinkles prepared by using a technology of a nano-capsule with excellent skin-permeability and stability comprises 5-15 vol% of sodium hyaluronate, 6-9 vol% of sodium polystyrene sulfonate, 4-6 vol% of sodium silicate, 4-6 vol% of acetyl hexapeptide-8, 0.5-2.0 vol% of proline, 0.5-2.5 vol% of lysine, 0.1-1.5 vol% of copper tripeptide-1, 0.1-1.0 vol% of dimethyl ethanol amine (DMEA), 0.2-0.9 vol% of pantothenic acid, 0.3-0.7 vol% of lecithin, 0.1-0.8 vol% of cholesterol, 0.2-0.7 vol% of ethylhexylglycerin, 0.3-0.8 vol% of caprylyl glycol, 0.1-0.6 vol% of hexylene glycol, 0.02-0.06 vol% of adenosine, 0.0001-0.01 vol% of rh-oligopeptide-1, and the remainder being water. Each of the proline, lysine, copper tripeptide-1, and lecithin is captured in the nano-capsule. (A volume of the nano-capsule is ignored.)

Description

Technical Field [0001] The present invention relates to a cosmetic composition for skin wrinkle improvement using a nanocapsule method having excellent skin permeability and stability. [0002] The present invention relates to a cosmetic composition for improving skin wrinkles,

The present invention relates to a cosmetic composition for improving skin wrinkles. More particularly, the present invention relates to a cosmetic composition for improving skin wrinkles using a nanocapsule construction method which is excellent in permeability and stability of skin penetration of an active ingredient deep into the skin, ≪ / RTI >

The skin is composed of epidermis, dermis and subcutaneous fat, which functions as a protective function, a barrier function, a temperature control function, an excretory function, and a respiratory function. The epidermis is the thinnest layer composed of organic bonds of keratinocytes and melanocytes. The dermis occupies about 95% of the skin, and is responsible for moisturizing and protecting the skin. Collagen and elastin, which are typical proteins that play an important role in skin elasticity (wrinkles), are distributed like nets, and blood vessels and nerves are present Mast cells that are involved in allergic reactions, and natural moisturizing factors such as Na-PCA or hyaluronic acid.

Subcutaneous fat plays a role in nutrition of the epidermis and dermis, body shape determination, body temperature maintenance, external shock absorption and cell protection under subcutaneous fat.

Such skin undergoes an aging process in which skin function is rapidly deteriorated due to intrinsic or extrinsic causes as the skin ages. As the aging progresses, the thickness of skin, dermis, and subcutaneous fat, which are constituents of the skin, becomes thinner, and collagen and elastin become thin and loose, resulting in decreased elasticity and wrinkles. In addition, when exposed to the sun or ultraviolet rays, lipid synthesis in the subcutaneous adipocytes is inhibited and the skin protection function is lost, resulting in rapid skin aging. In the face, breast and buttocks, Beauty can not be pursued.

A prior art related to the present invention is Korean Patent Registration No. 10-0816261 (published on March 25, 2008), which discloses a cosmetic composition for improving skin wrinkles containing an extract of Magnolia sieboldii as an active ingredient.

It is an object of the present invention to provide a cosmetic composition for improving skin wrinkles by using a nanocapsule method which is excellent in permeability and stability of skin penetration of an active ingredient deep into the skin to improve wrinkles and whitening of the skin.

In order to accomplish the above object, the present invention provides a cosmetic composition for improving skin wrinkles using nanocapsule having excellent permeability and stability of skin, comprising 5 to 15% by volume of sodium hyaluronate, 5 to 15% by volume of sodium polystyrenesulfonate polystyrene sulfonate: 6 to 9 vol%, sodium silicate: 4 to 6 vol%, acetyl hexapeptide-8: 4 to 6 vol%, proline: 0.5 to 2.0 vol 0.1 to 1.5 vol%, lysine: 0.5 to 2.5 vol%, copper tripeptide-1: 0.1 to 1.5 vol%, dimethylethanolamine (DMEA): 0.1 to 1.0 vol%, pantothenic acid The present invention relates to a pharmaceutical composition comprising a pantothenic acid of 0.2 to 0.9 vol%, a lecithin of 0.3 to 0.7 vol%, a cholesterol of 0.1 to 0.8 vol%, an ethylhexyl glycerin of 0.2 to 0.7 vol% capryl glycol glycol: 0.3-0.8 vol%, hexylene glycol: 0.1-0.6 vol%, and adenosine: 0.02-0. Wherein the proline, lysine, caprate peptide-1 and lecithin each comprise water at a concentration of 0.0001-0.0 vol%, rh-oligopeptide-1: 0.0001-0.01 vol%, and balance of vol% And is captured in the nanocapsule.

(Here, the volume of the nanocapsule is neglected.)

The cosmetic composition for improving skin wrinkles using the nanocapsule method having excellent skin permeability and stability according to the present invention is characterized in that proline, lysine, capper tripeptide-1 and lecithin are respectively collected in a nanocapsule composed of a fat-soluble substance, The active ingredient of proline, lysine, capecitabine-1 and lecithin, which are captured in the nanocapsules, is directly absorbed in the dermis layer, thereby maximizing the skin wrinkle and whitening effect.

In addition, the cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to the present invention is useful for the production of collagen by adding an anti-aging amino acid mixture such as proline, lysine and capper tripeptide-1 It can help healthy and elastic skin care. By adding low molecular weight sodium hyaluronate, it can form a moisturizing film on the inner and outer sides of the skin, double strengthening the skin barrier, have.

In addition, the cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to the present invention is characterized in that sodium polystyrene sulfonate which helps skin elasticity and acetyl hexapeptide-8 The effect of spreading the wrinkles immediately upon application to the skin due to the skin elasticity effect can be achieved.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. It should be understood, however, that the invention is not limited to the disclosed embodiments, but is capable of many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout the specification.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a cosmetic composition for improving skin wrinkles using the nanocapsule method having excellent skin permeability and stability according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

Cosmetic composition for improving skin wrinkles

The cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to the embodiment of the present invention is characterized in that proline, lysine, capper tripeptide-1 and lecithin are respectively collected in a nanocapsule composed of a fat soluble material, It can penetrate deeply into the pores of the skin and melt in the dermis layer, so that the active ingredient of proline, lysine, capper tripeptide-1 and lecithin captured in the nanocapsules is directly absorbed in the dermis layer, thereby maximizing the skin wrinkle and whitening effect .

In addition, the cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to the embodiment of the present invention is characterized in that the anti-aging amino acid mixture of proline, lysine and capper tripeptide- Helps provide healthy and elastic skin care and low molecular weight sodium hyaluronate is added to form a moisturizing layer inside and outside of the skin to double skin barrier and instantly wrinkle. .

In addition, the cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to the embodiment of the present invention is characterized in that sodium polystyrene sulfonate which helps skin elasticity and acetyl hexapeptide-8 which is a component of Botox anti- The effect of spreading the wrinkles immediately upon application to the skin due to the skin elasticity effect can be achieved.

To this end, the cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to an embodiment of the present invention comprises 5 to 15 vol% of sodium hyaluronate, sodium polystyrene sulfonate, : 6 to 9 vol%, sodium silicate: 4 to 6 vol%, acetyl hexapeptide-8: 4 to 6 vol%, proline: 0.5 to 2.0 vol%, lysine 0.1 to 1.5 vol% of lysine, 0.5 to 2.5 vol%, copper tripeptide-1, 0.1 to 1.0 vol% of dimethyl ethanolamine (DMEA), pantothenic acid, : 0.2 to 0.9 vol%, lecithin: 0.3 to 0.7 vol%, cholesterol: 0.1 to 0.8 vol%, ethylhexylglycerin: 0.2 to 0.7 vol%, caprylyl glycol, : 0.3 to 0.8 vol%, hexylene glycol: 0.1 to 0.6 vol%, adenosine: 0.02 to 0.06 vol% Wherein the proline, lysine, capper tripeptide-1 and lecithin are each contained in a nanocapsule, wherein the proline, lysine, caplet tripeptide-1 and lecithin are contained in 0.0001 to 0.01 vol% . Here, the volume of the nanocapsules was ignored.

At this time, it is preferable that the nanocapsules are made of a lipolytic substance. As each of proline, lysine, capper tripeptide-1 and lecithin is trapped in nanocapsules composed of lipolytic substances, it can stably penetrate deep into the pores of the skin and melt in the dermal layer. Therefore, , Lysine, capper tripeptide-1 and lecithin are directly absorbed in the dermis layer, thereby maximizing the skin wrinkles and whitening effects. At this time, the nanocapsules may have a diameter of 100 to 30,000 nm, more preferably 100 to 10,000 nm, and most preferably 100 to 1,000 nm.

For example, the nanocapsule may be prepared by polymerizing a hydrophobic polymer having a cationic functional group capable of adsorbing an active ingredient of proline, lysine, capper tripeptide-1 and lecithin, and then using a Nano precipitation method . That is, a hydrophobic polymer having an active ingredient and a cationic functional group is dissolved in a suitable organic solvent, that is, a solvent having high volatility, which is non-toxic and can be mixed with water and has a lower vapor pressure than that of water, Thereby preparing an emulsion by self-association, and then evaporating the organic phase to produce nanocapsules present in the aqueous phase.

In addition, the cosmetic composition for improving skin wrinkles using the nanocapsule method having superior skin permeability and stability according to an embodiment of the present invention is characterized by comprising ascorbic acid: 0.3 to 0.6 vol%, potassium sorbate: 0.35 vol.% And phenoxyethanol: 0.01 to 0.08 vol.%.

Hereinafter, the composition ratio of the active ingredients contained in the cosmetic composition for improving skin wrinkles using the nanocapsule method having excellent skin permeability and stability according to the embodiment of the present invention and its role will be described.

Sodium hyaluronate is a representative substance having the function of improving wrinkles and preventing aging. The sodium hyaluronate acts as a moisturizing agent that double-strengthens the skin barrier by forming a moisturizing layer on the inside and outside of the skin. For this purpose, sodium hyaluronate having a low molecular weight of 60 kDa or less is more preferably used. Sodium hyaluronate is preferably added in an amount of 5 to 15 vol%, more preferably 8 to 12 vol%, and most preferably 10 vol%, of the total volume of the cosmetic composition.

When the addition amount of sodium hyaluronate is less than 5 vol%, it is difficult to exert the above effect properly. On the contrary, when the addition amount of sodium hyaluronate is more than 15 vol%, it is not economical because it can act as a factor for raising the manufacturing cost only without increasing the effect.

Sodium polystyrene sulfonate helps to give the skin elasticity that is loosened to the skin firmly. In order to achieve the above effect, sodium polystyrenesulfonate is preferably added in an amount of 6 to 9 vol%, more preferably 7 to 8 vol%, most preferably 7.5 vol% % Can be presented.

Sodium silicate acts as a preservative to suppress degeneration and decay. For this purpose, the sodium silicate is preferably added in an amount of 4 to 6 vol%, more preferably 4.5 to 5.5 vol%, most preferably 5 vol% Can be presented.

Acetyl hexapeptide-8 is a botulinum toxin-like wrinkle ingredient, which has similar physical properties to Botox protein and improves skin elasticity in a short time. In addition, acetylhexapeptide-8 is a highly concentrated multi-peptide that imparts elastic skin texture and plays a role in spreading various wrinkles such as shallow wrinkles, deep wrinkles and facial wrinkles. In order to achieve the above effect, the acetyl hexapeptide is preferably added in an amount of 4 to 6 vol%, more preferably 4.5 to 5.5 vol%, of the total volume of the cosmetic composition, 5 vol% can be presented.

Proline, one of the amino acids that make up proteins, is biosynthesized in glutamic acid, which is metabolized to glutamic acid in the same process as the reverse reaction of biosynthesis. These prolines are responsible for improving moisturizing, cell proliferation, promoting collagen synthesis, skin elasticity and skin wrinkles. Such proline is preferably added in an amount of 0.5 to 2.0 vol%, more preferably 0.8 to 1.2 vol%, and most preferably 1.0 vol%, of the total volume of the cosmetic composition .

Like proline, lysine plays a role in improving moisturizing, cell proliferation, promoting collagen synthesis, skin elasticity and skin wrinkles. These lysines are added with proline to help with collagen production, helping to maintain healthy and resilient skin. Therefore, lysine is preferably added in an amount of 0.5 to 2.5 vol%, more preferably 0.8 to 1.2 vol%, and most preferably 1.0 vol% of the total volume of the cosmetic composition. have.

Copper tripeptide-1 is one of the anti-aging amino acid mixtures added with proline and lysine. Such capper tripeptide-1 serves to improve moisturizing, cell proliferation, promoting collagen synthesis, skin elasticity and skin wrinkles. For this purpose, the copper tripeptide-1 is preferably added in an amount of 0.1 to 1.5 vol%, more preferably 0.8 to 1.2 vol%, of the total volume of the cosmetic composition, and most preferably, Can be 1.0 vol%.

Dimethyl Ethanol Amine (DMEA) and pantothenic acid are used as organic solvents, respectively. Dimethyl Ethanol Amine (DMEA) and pantothenic acid are preferably added in an amount of 0.1 to 1.0 vol% and 0.2 to 0.9 vol%, respectively, of the total volume of the cosmetic composition. In this case, a more preferable range of dimethylethanolamine is 0.4 to 0.6 vol%, and most preferably 0.5 vol%. A more preferable range of pantothenic acid is 0.4 to 0.6 vol%, and most preferably 0.5 vol%.

Lecithin controls the moisture in skin cells, preventing skin aging and skin deposits. Such lecithin is preferably added in an amount of 0.3 to 0.7 vol%, more preferably 0.4 to 0.6 vol%, and most preferably 0.5 vol%, of the total volume of the cosmetic composition.

When the addition amount of lecithin is less than 0.3 vol%, the addition amount of the lecithin is insufficient, and it is difficult to exhibit the skin aging and the effect of preventing the skin deposition. On the contrary, when the addition amount of lecithin is more than 0.7 vol%, it is not preferable because it can act as a factor for raising the manufacturing cost without increasing the effect.

Cholesterol (cholesterol) is a basic substance required to constitute the cell membrane of animal cells. It is synthesized only in animals without being synthesized in plants. These cholesterol are needed to make cell membranes. The cholesterol is preferably added in an amount of 0.1 to 0.8 vol%, more preferably 0.4 to 0.6 vol%, and most preferably 0.5 vol% of the total volume of the cosmetic composition.

Ethylhexyl glycerin (ethylhexylglycerin) acts as a moisturizer with antimicrobial action and plays a role in improving skin elasticity. Such ethylhexyl glycerin is preferably added in an amount of 0.2 to 0.7 vol%, more preferably 0.4 to 0.6 vol%, and most preferably 0.5 vol% of the total volume of the cosmetic composition.

When the amount of the ethylhexyl glycerin added is less than 0.2 vol%, the amount of the added ethylhexyl glycerin is insufficient and it is difficult to exert the preservative effect properly. Conversely, when the addition amount of ethylhexyl glycerin is more than 0.7 vol%, the increase of the preservative effect is insignificant compared with the increase amount, and it acts as a factor to reduce the amount of use of other components, which is not preferable.

Caprylyl glycol acts as a moisturizing agent with antimicrobial action. Even if it is used alone, sufficient preservative effect can be obtained, and the amount of the chemical preservative can be greatly reduced, but it may adversely affect the stability of the formulation when used in large amounts . Therefore, caprylyl glycol is preferably added in an amount of 0.3 to 0.8 vol%, more preferably 0.4 to 0.6 vol%, most preferably 0.5 vol% .

Hexylene glycol is added as a coupling agent. Such hexylene glycol is preferably added in an amount of 0.1 to 0.6 vol%, more preferably 0.4 to 0.6 vol%, and most preferably 0.5 vol%, based on the total volume of the cosmetic composition.

Adenosine is a combination of adenine and ribose components, and is a representative anti-aging and anti-wrinkle ingredient certified and notified by the KFDA. These adenines promote the synthesis of collagen in the dermis layer, thereby reducing wrinkles and restoring elasticity. For this purpose, it is preferable that the adenine is added in an amount of 0.02 to 0.06 vol%, more preferably 0.03 to 0.05 vol%, and most preferably 0.04 vol%, of the total volume of the cosmetic composition.

Al-O-oligopeptide is an epithelial cell growth factor and cell regenerating factor, and plays a role in improving skin wrinkles. For this purpose, the rh-oligopeptide is preferably added in an amount of 0.0001 to 0.01 vol%, more preferably 0.0006 to 0.008 vol%, of the total volume of the cosmetic composition, and most preferably, 0.001 vol% can be presented.

Ascorbic acid acts as an antioxidant. It is preferable that such ascorbic acid is added in an amount of 0.3 to 0.6 vol%, more preferably 0.3 to 0.5 vol%, and most preferably 0.45 vol% of the total volume of the cosmetic composition .

Potassium sorbate is added as a preservative to inhibit denaturation and decay. Such potassium sorbate is preferably added in an amount of 0.15 to 0.35 vol%, more preferably 0.20 to 0.30 vol%, and most preferably 0.25 vol%, of the total volume of the cosmetic composition.

Phenoxyethanol is a phenol ether with a combination of phenol and ethylene glycol, added as a preservative and a preservative. Such phenoxyethanol is preferably added in an amount of 0.01 to 0.08 vol%, more preferably 0.04 to 0.06 vol%, and most preferably 0.05 vol%, based on the total volume of the cosmetic composition.

Distilled water may be used as water, and it is preferable to use deionized distilled water.

Example

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. It is to be understood, however, that the same is by way of illustration and example only and is not to be construed in a limiting sense.

The contents not described here are sufficiently technically inferior to those skilled in the art, and a description thereof will be omitted.

1. Preparation of cosmetic composition

The cosmetic compositions according to Examples 1 to 5 and Comparative Example 1 were prepared with the compositions shown in Table 1. At this time, in the case of the cosmetic composition according to Examples 1 to 5, proline, lysine, capper tripeptide-1 and lecithin were collected in nanocapsules. Here, the volume of the nanocapsules was ignored.

[Table 1] (Unit: vol%)

2. Evaluation of skin wrinkle improvement effect

Table 2 shows the results of evaluating the effect of improving the skin wrinkles on the cosmetic composition according to Examples 1 to 5 and Comparative Example 1. In order to evaluate the immediate wrinkle improvement effect, 30 women aged 40 to 60 years were applied to the skin of the eyes once after washing to measure the wrinkle depth. Wrinkle depth measurement The camera attached to the equipment is focused on the eyelid skin, and the image is taken. The depth of the wrinkle is measured by the image analyzer software to set the initial value, and the set measurement position And the cosmetic composition was applied. After 10 minutes, the wrinkle depth reduction rate was measured. At this time, evaluation criteria were determined by measuring the crease depth reduction rate (%) with the initial crease depth set to '0', and the average value of the measurement object was calculated and shown.

[Table 2]

As shown in Table 2, when the cosmetic composition according to Examples 1 to 5 is applied and used, it is found that there is an immediate effect of improving skin wrinkles.

On the other hand, when the cosmetic composition according to Comparative Example 1 is applied and used, the effect of improving skin wrinkles is not large.

As can be seen from the above experimental results, it was found that when the proline, lysine, capper tripeptide-1 and lecithin, which were respectively collected in the nanocapsules were used as in the cosmetic composition according to Examples 1 to 5, It was found that the effect of improving the wrinkles of the skin was greatly improved as compared with the composition.

Although the preferred embodiments of the present invention have been disclosed for illustrative purposes, those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims. These changes and modifications may be made without departing from the scope of the present invention. Accordingly, the scope of the present invention should be determined by the following claims.

Claims (6)

Sodium hyaluronate: 5 to 15 vol%, sodium polystyrene sulfonate: 6 to 9 vol%, sodium silicate: 4 to 6 vol%, acetyl hexapeptide-8 -8): 4 to 6 vol%, proline: 0.5 to 2.0 vol%, lysine: 0.5 to 2.5 vol%, copper tripeptide-1: 0.1 to 1.5 vol% 0.1 to 1.0 vol%, pantothenic acid: 0.2 to 0.9 vol%, lecithin: 0.3 to 0.7 vol%, cholesterol: 0.1 to 0.8 vol%, dimethylethanolamine (DMEA) 0.2 to 0.7 vol% of ethylhexyl glycerin, 0.3 to 0.8 vol% of caprylic glycol, 0.1 to 0.6 vol% of hexylene glycol, 0.02 to 0.6 vol% of adenosine, 0.06 to 0.06 vol.%, Rh-oligopeptide-1: 0.0001 to 0.01 vol.%, And balance of vol.%,
The proline, lysine, capper tripeptide-1 and lecithin, respectively, are entrapped in nanocapsules and have superior skin permeability and stability.
(Here, the volume of the nanocapsule is neglected.)
delete The method according to claim 1,
The nanocapsule
And having a diameter of 100 to 30,000 nm. The cosmetic composition for improving skin wrinkles using the nanocapsule method has excellent skin permeability and stability.
The method according to claim 1,
The sodium hyaluronate
Wherein the composition has a low molecular weight of 60 kDa or less and is excellent in skin permeability and stability.
The method according to claim 1,
The cosmetic composition
, At least one of ascorbic acid: 0.3 to 0.6 vol%, potassium sorbate: 0.15 to 0.35 vol%, and phenoxyethanol: 0.01 to 0.08 vol% Which is superior in skin permeability and stability, is used as a cosmetic composition for improving skin wrinkles.
The method according to claim 1,
The cosmetic composition
Sodium hyaluronate: 10 vol%, sodium polystyrene sulfonate: 7.5 vol%, sodium silicate: 5 vol%, acetyl hexapeptide-8: 5 vol 1.0 vol%, lysine: 1.0 vol%, copper tripeptide-1: 1.0 vol%, dimethylethanolamine (DMEA): 0.5 vol%, proline: 1.0 vol% 0.5 vol.% Of pantothenic acid, 0.5 vol.% Of lecithin, 0.5 vol.% Of cholesterol, 0.5 vol. Of ethylhexylglycerin, 0.5 of capryllyl glycol , 0.5 vol% of hexylene glycol, 0.45 vol% of ascorbic acid, 0.25 vol% of potassium sorbate, 0.05 vol% of phenoxyethanol, 0.04 vol.% of adenosine, 0.001 vol.% of rh-oligopeptide-1 and the remainder of vol.% Wrinkle cosmetic composition for with skin permeability and the excellent stability nanocapsules method according to claim.