KR20210012350A - Artificial layer cream composition having superior moisture retention and skin penetration effect by nanoliposome treatment method - Google Patents

Abstract

The present invention discloses an artificial layer cream composition having an excellent moisturizing power and skin penetration effect by a nanoliposome treatment method which can achieve excellent moisturizing power and skin penetration effect by helping active components to be absorbed into the skin of human body by maintaining stability of the preparation without dissolution of active components since active components are captured in a multi-layered nanocapsule by nanoliposome treatment.

Description

Artificial film cream composition having excellent moisturizing power and skin penetration effect by nano liposome treatment method {ARTIFICIAL LAYER CREAM COMPOSITION HAVING SUPERIOR MOISTURE RETENTION AND SKIN PENETRATION EFFECT BY NANOLIPOSOME TREATMENT METHOD}

The present invention relates to an artificial membrane cream composition, and more particularly, by nano-liposome treatment, an active ingredient is collected in a multilayer nanocapsule, thereby maintaining the stability of the formulation without dissolution of the active ingredient, helping to be absorbed into the skin of the human body. It relates to an artificial membrane cream composition having excellent moisturizing power and skin penetrating effect by a nano-liposome treatment method capable of promoting moisturizing power and skin penetration effect.

The skin is an organ that has a protective function, a barrier function, a temperature control function, an excretory function, and a respiratory function, and is composed of epidermis, dermis and subcutaneous fat. The epidermis is the thinnest layer and consists of organic bonds of keratinocytes and melanocytes. The dermis occupies about 95% of the skin, and is a layer responsible for moisturizing and protecting the skin. Collagen and elastin, representative proteins that play an important role in skin elasticity (wrinkles), are distributed like a net, and blood vessels and nerves are present. It also contains mast cells involved in allergic reactions, and natural moisturizing factors such as Na-PCA or hyaluronic acid.

Subcutaneous fat plays a role in supplying nutrients to the epidermis and dermis, determining body shape, maintaining body temperature, absorbing external shocks, and protecting cells under the subcutaneous fat.

The stratum corneum layer of the epidermis, which is the outermost layer of the skin described above, serves as a barrier against the external harmful environment and plays an important function of preventing moisture evaporation of the skin. Dry skin is caused by an increase in transepidermal water loss (TEWL) due to an abnormality in the skin barrier due to insufficient moisture in the stratum corneum.

However, the conventional artificial film cream composition is applied by simply applying it to the human skin.In this case, no matter how effective a material is used, the active ingredient cannot penetrate into the skin and stay outside the skin, so that the effect can be exhibited properly. none.

That is, since the human skin acts as a barrier that effectively protects the human body from external stimuli, the active ingredients of the artificial membrane cream composition cannot be easily absorbed.

Therefore, in recent years, research to develop an artificial membrane cream composition capable of promoting absorption without irritating the skin has been actively conducted.

As a related prior document, Korean Laid-Open Patent Publication No. 10-2002-0076874 (published on October 11, 2002), which describes a hypoallergenic and highly moisturizing artificial film cream composition.

An object of the present invention is that the active ingredients are collected in the multilayer nanocapsules by nano-liposome treatment, so that the stability of the formulation is maintained without elution of the active ingredients, thereby helping to be absorbed into the skin of the human body, thereby achieving excellent moisturizing power and skin penetration It is to provide an artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the existing nano liposome treatment method.

The artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to the embodiment of the present invention to achieve the above object is in weight %, caffeine: 0.5 to 12%, sodium hyaluronate (sodium hyaluronate): 4 ~ 6%, aloe barbadensis leaf juice: 3 ~ 7%, carbomer: 1.5 ~ 3.5%, film forming agent: 1 ~ 3%, xantan gum: 0.5 ~ 2.5%, Glycerin: 0.5 ~ 1.5%, Cetearyl alcohol: 0.5 ~ 1.5%, Kaolin: 0.1 ~ 1.0%, Bentonite: 0.1 ~ 1.0%, Cholesterol (cholesterol): 0.2 ~ 0.8%, lecithin: 0.3 ~ 0.7%, acrylic acid-based anionic water-soluble polymer compound: 0.3 ~ 0.7%, myristoyl pentapeptide-11: 0.5 ~ 1.5% , Myristoyl pentapeptide-8: 0.3 ~ 0.6%, acetyl hexapeptide-8: 0.05 ~ 0.20%, SH-polypeptide-11 (sh-polypeptide-11) : 0.00005 ~ 0.00020%, SH-oligopeptide-1 (sh-oligopeptide-1): Includes 0.00005 ~ 0.00020% and the rest of water.

At this time, the myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetylhexapeptide-8, SH-polypeptide-11, and SH-oligopeptide-1 were treated with nano-liposomes, It is trapped inside.

Here, the film forming agent may be sodium acrylate copolymer or octofluoropentyl methacrylate.

In addition, the acrylic acid-based anionic water-soluble polymer compound is preferably an acrylate/C10-30 alkyl acrylate crosspolymer (acrylates/C10-30　alkyl　acrylate　crosspolymer).

The multilayer nanocapsule is made of a fat-soluble material that is decomposed by heat.

At this time, the film forming agent, xantan gum, glycerin, cetearyl alcohol, kaolin, bentonite, cholesterol, lecithin, and acrylic acid-based The anionic water-soluble polymer compound acts as a major component for film formation when applied to the skin.

In addition, the myristoyl pentapeptide-11 (myristoyl pentapeptide-11), myristoyl pentapeptide-8 (myristoyl pentapeptide-8), acetyl hexapeptide-8 (acetyl hexapeptide-8), SH-polypeptide-11 ( sh-polypeptide-11) and SH-oligopeptide-1 act as active ingredients to form a breathable protein membrane along with the main ingredients for film formation when applied to the skin.

The artificial membrane cream composition is in weight%, caprylyl glycol: 0.3 to 0.8%, hexylene glycol: 0.3 to 0.7%, ethylhexylglycerin: 0.2 to 0.7%, lysine ( lysine): 0.00001 to 0.00020%, proline: 0.00001 to 0.00020%, glycine: 0.00001 to 0.00020%, malus domestica fruit cell culture extract: 0.2 to 0.8%, yellow tangerine Citrus grandis (grapefruit) seed extract: 0.1 ~ 0.4%, silk amino acids: 0.05 ~ 0.30%, fullerenes: 0.01 ~ 0.20% and arbutin: 0.05 ~ 0.30% It may further include one or more.

The artificial membrane cream composition according to the present invention is transparent on the surface of the skin due to the combination of an acrylic acid-based anionic water-soluble high molecular compound acrylate/C10-30 alkyl acrylate crosspolymer with sodium acrylate copolymer (or octofluoropentyl methacrylate). By forming a breathable protein film, which is a silicone-type skin protective film, it keeps the skin moisturized, and liposomes using cholesterol, lecithin, etc. act as multi-layer nanocapsules to maintain the stability of the formulation without elution of active ingredients and are absorbed into the human skin. Help.

As a result, the artificial membrane cream composition according to the present invention prevents the loss of moisture and oil from the skin by effectively and continuously penetrating the active ingredients deep into the skin throughout the sleep time by acting as a hermetic therapy with the breathable protein membrane formed on the skin.

Accordingly, the artificial membrane cream composition according to the present invention can exhibit an immediate effect of providing sufficient nutrition and moisturizing effect to the skin without penetrating the breathable protein membrane into the skin of the human body, correcting skin sagging, and maintaining elasticity.

Accordingly, according to the present invention, when the artificial membrane cream composition is applied to the skin of the human body and dried, a breathable protein membrane that is perfectly adhered to the skin is formed to inhibit moisture evaporation from the skin of the human body, and fundamentally restore the damaged skin barrier to treat atopy. effective.

In addition, the present invention forms a transparent silicone-type skin protective film by combining an acrylate/C10-30 alkyl acrylate crosspolymer and a sodium acrylate copolymer (or octofluoropentyl methacrylate). When applied to the skin of the human body and applied on it, it can exert a booster effect that radiates brightly like water-glossy skin.

1 is a schematic diagram for explaining an artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method according to an embodiment of the present invention.
Figure 2 is a schematic diagram for explaining the skin penetration process of the active ingredient of the artificial membrane cream composition according to an embodiment of the present invention.

Advantages and features of the present invention, and a method of achieving them will become apparent with reference to the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in a variety of different forms, only this embodiment is to complete the disclosure of the present invention, and the general knowledge in the technical field to which the present invention pertains. It is provided to completely inform the scope of the invention to those who have it, and the invention is only defined by the scope of the claims. The same reference numerals refer to the same elements throughout the specification.

Hereinafter, an artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

Artificial membrane cream composition

The artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to an embodiment of the present invention is an acrylic acid-based anionic water-soluble polymer compound, acrylate/C10-30 alkyl acrylate crosspolymer, is sodium acrylate copolymer (Or octofluoropentyl methacrylate) forms a breathable protein film that is a transparent silicone-type skin protective film on the surface of the skin to keep the skin moisturized, and liposomes using cholesterol and lecithin work as a multilayer nanocapsule. It helps to be absorbed into the human skin by maintaining the stability of the formulation without elution of active ingredients.

As a result, in the artificial membrane cream composition according to an embodiment of the present invention, the breathable protein membrane formed on the skin acts as a hermetic therapy, so that the active ingredient effectively and continuously penetrates deep into the skin throughout the sleep period to prevent moisture and oil loss from the skin.

Therefore, the artificial membrane cream composition according to an embodiment of the present invention can exhibit an immediate effect of providing sufficient nutrition and moisturizing effect to the skin without penetrating the breathable protein membrane into the skin of the human body, correcting skin sagging, and maintaining elasticity. .

Accordingly, according to the present invention, when the artificial membrane cream composition is applied to the skin of the human body and dried, a breathable protein membrane that is perfectly adhered to the skin is formed to inhibit moisture evaporation from the skin of the human body, and fundamentally restore the damaged skin barrier to treat atopy. effective.

In addition, the present invention forms a transparent silicone-type skin protective film by combining an acrylate/C10-30 alkyl acrylate crosspolymer and a sodium acrylate copolymer (or octofluoropentyl methacrylate). When applied to the skin of the human body and applied on it, it can exert a booster effect that radiates brightly like water-glossy skin.

To this end, the artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to an embodiment of the present invention is in weight %, caffeine: 0.5 to 12%, sodium hyaluronate: 4 ~ 6%, aloe barbadensis leaf juice: 3 ~ 7%, carbomer: 1.5 ~ 3.5%, film forming agent: 1 ~ 3%, xantan gum: 0.5 ~ 2.5 %, Glycerin: 0.5 ~ 1.5%, cetearyl alcohol: 0.5 ~ 1.5%, kaolin: 0.1 ~ 1.0%, bentonite: 0.1 ~ 1.0%, cholesterol (cholesterol) : 0.2 to 0.8%, lecithin: 0.3 to 0.7%, acrylic acid-based anionic water-soluble polymer compound: 0.3 to 0.7%, myristoyl pentapeptide-11: 0.5 to 1.5%, myristol Myristoyl pentapeptide-8: 0.3 ~ 0.6%, acetyl hexapeptide-8: 0.05 ~ 0.20%, SH-polypeptide-11: 0.00005 ~ 0.00020%, SH-oligopeptide-1: 0.00005 ~ 0.00020% and the rest of the water is included.

At this time, myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetylhexapeptide-8, SH-polypeptide-11, and SH-oligopeptide-1 were treated with nanoliposomes, and the interior of the multilayer nanocapsule Is captured in.

These multi-layered nanocapsules have a structure in which low-molecularized molecules are overlapped to form layers, and the active ingredient is collected between the layer and the layer in a special shape of a hollow sphere. These multi-layer nanocapsules are made of fat-soluble substances that are decomposed by heat when applied to the skin of the human body, so they pass between the cells of the skin and gradually dissolve by the decomposing enzymes in the skin, opening the pores and keeping the active ingredient deep in the skin for a long time. Can be sent to.

In addition, multilayer nanocapsules are not synthetic chemicals, but natural ingredients made of phospholipids such as cholesterol and lecithin, and have a structure that is quite similar to human skin because it is in the form of a lipid double membrane such as a skin cell membrane.

Accordingly, it is possible to inject a water-soluble active ingredient that is difficult to penetrate into the skin of the human body to the inside of the stratum corneum, and inject a fat-soluble ingredient that is difficult to mix into the dermal layer of the skin.

Hereinafter, each component included in the artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to an embodiment of the present invention, and its composition ratio and role will be described.

Caffeine is a white crystal that has a xanthine structure with three methyl groups, is difficult to dissolve in cold water, well soluble in hot water, and tastes bitter. This caffeine has a pharmacological action such as a central nervous system stimulant, a cardiac agent, a diuretic, etc., and has the effect of decomposing fat, especially cellulite, thereby promoting fat decomposition.

Such caffeine is preferably added in an amount of 0.5 to 12% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 9 to 10% by weight.

When the amount of caffeine added is less than 0.5% by weight, the fat decomposition effect is low. On the contrary, when the amount of caffeine added exceeds 12% by weight, the amount of niacinamide required for dissolution is excessive and even if dissolved, it is vulnerable to nucleation due to local water evaporation at the container wall when left for a long time. There is a risk that precipitation may be induced.

Sodium hyaluronate is a representative material that has the function of improving wrinkles and preventing aging. This sodium hyaluronate acts as a moisturizing agent that doubles the skin barrier by forming a moisturizing film inside and outside the skin. For this purpose, it is more preferable to use sodium hyaluronate having a low molecular weight of 60 kDa or less. Such sodium hyaluronate is preferably added in 4 to 6% by weight of the total weight of the artificial film composition of the present invention, more preferably 4.5 to 5.5% by weight can be presented.

When the amount of sodium hyaluronate is less than 4% by weight, it is difficult to properly exhibit the above effect. On the contrary, if the amount of sodium hyaluronate exceeds 6% by weight, it is not economical because it can act as a factor that increases only the manufacturing cost without further increasing the effect.

Aloe barbadensis leaf juice is a perennial herb belonging to the lily family, and has analgesic, anti-allergic, antibacterial, tonic, anti-inflammatory, anti-tumor effects, lowering blood sugar, and alleviating cadmium toxicity. In particular, aloe vera leaf juice has excellent effects on atopy treatment, skin cell regeneration, wound healing, and skin moisturization.

Such aloe vera leaf juice is preferably added in an amount of 3 to 7% by weight of the total weight of the artificial membrane cream composition of the present invention, and more preferably 4 to 5% by weight may be presented.

When the amount of aloe vera leaf juice is less than 3% by weight, it is difficult to properly exhibit the above effect. On the contrary, when the amount of aloe vera leaf juice added exceeds 7% by weight, it is not economical because it can act as a factor that increases only the manufacturing cost without further increasing the effect.

Carbomers are added as thickeners that control the viscosity of the membrane. These carbomers are preferably added in an amount of 1.5 to 3.5% of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 2.0 to 3.0% by weight.

If the amount of carbomer is less than 1.5% by weight, there may be a problem of thinning due to low viscosity. Conversely, when the amount of carbomer exceeds 3.5% by weight, the viscosity is too high, so that the usability is deteriorated, and the formulation may not be stabilized.

The film-forming agent is combined with acrylates/C10-30 alkyl acrylate crosspolymer to form a transparent silicone-type skin protective film to maintain skin moisture. At this time, the film forming agent may be sodium acrylate copolymer or octofluoropentyl methacrylate.

Such a film forming agent is preferably added in an amount of 1 to 3% by weight of the total weight of the artificial film composition of the present invention, and a more preferable range may be 1.5 to 2.5% by weight.

When the amount of the film forming agent added is less than 1% by weight, it is difficult to properly exert the effect of maintaining the moisture of the skin. On the contrary, when the amount of sodium acrylate copolymer added exceeds 3% by weight, it is not economical because it can act as a factor that only increases the manufacturing cost without further increasing the effect.

Xantan gum is added as a thickener to control the viscosity of the film in the liquid state. Xanthan gum is preferably added in an amount of 0.5 to 2.5% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 1.0 to 2.0% by weight.

If the amount of xanthan gum added is less than 0.5% by weight, the viscosity may be low and there may be a problem of thinning. Conversely, when the amount of xanthan gum added exceeds 2.5% by weight, the viscosity becomes too high, so that the usability decreases, and the formulation may not be stabilized.

Glycerin is added together with xanthan gum as a thickener to control the viscosity of the membrane. Such glycerin is preferably added in an amount of 0.5 to 1.5% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.8 to 1.2% by weight.

When the amount of glycerin is less than 0.5% by weight, the viscosity may be low and there may be a problem of thinning. Conversely, when the amount of glycerin exceeds 1.5% by weight, the viscosity is too high, so that the usability is deteriorated, and the formulation may not be stabilized.

Cetearyl alcohol works with xanthan gum and glycerin to act as a thickener and binder to control the viscosity of the liquid film and prevent evaporation and absorption from the skin of the film while drying. It seals the skin by maintaining a solid film on the skin surface.

Such cetearyl alcohol is preferably added in an amount of 0.5 to 1.5% by weight of the total weight of the artificial membrane cream composition of the present invention, and 0.8 to 1.2% by weight may be suggested as a more preferable range.

If the amount of cetearyl alcohol is less than 0.5% by weight, it may be difficult to properly exhibit the moisture evaporation prevention effect. On the contrary, when the amount of cetearyl alcohol added exceeds 1.5% by weight, it precipitates as a lump upon drying, which may act as a factor that reduces skin absorption of the active ingredient.

Kaolin is added as a film-forming agent to improve adhesion by adhering the film to the skin surface.

Such kaolin is preferably added in an amount of 0.1 to 1.0% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.4 to 0.7% by weight.

If the amount of kaolin is less than 0.1% by weight, it may be difficult to secure adhesion. When the added amount of kaolin exceeds 1.0% by weight, it is not completely dissolved in water, which may affect the stability and formulation of the artificial membrane cream composition.

Bentonite works with kaolin to have adhesive strength as a film-forming agent, and when a liquid artificial film cream composition is applied to the skin by intimate contact with the skin surface, it prevents evaporation of moisture from the skin and adsorbs waste products. Plays a role.

Such bentonite is preferably added in an amount of 0.1 to 1.0% by weight of the total weight of the artificial film composition of the present invention, and a more preferable range may be 0.5 to 0.8% by weight.

When the amount of bentonite is less than 0.1% by weight, it may be difficult to properly exhibit the above effect. Conversely, when the amount of bentonite exceeds 1.0% by weight, it is not completely dissolved in water, and thus the stability and formulation of the artificial film cream composition may be affected.

Cholesterol is a basic substance necessary to make up the cell membrane of animal cells. It is not synthesized in plants, but only in animals. Cholesterol is a lipid component like the skin that acts together with lecithin and becomes an emulsifying stabilizer and emulsifier. It has adhesion to the skin, and the membrane adheres to the skin surface to seal the skin surface.

Such cholesterol is preferably added in 0.2 to 0.8% by weight of the total weight of the artificial membrane cream composition of the present invention, more preferably 0.4 to 0.6% by weight can be presented.

Lecithin works with skin cholesterol to act as an emulsion stabilizer and emulsifier to have adhesion to the skin, so that the film adheres to the skin surface to seal the skin surface.

Such lecithin is preferably added in an amount of 0.3 to 0.7% by weight of the total weight of the artificial membrane cream composition of the present invention, and more preferably 0.4 to 0.6% by weight may be presented.

When the amount of lecithin is less than 0.3% by weight, the amount of lecithin is insignificant and it is difficult to properly exhibit the effect of preventing skin aging and skin deposition. Conversely, if the amount of lecithin exceeds 0.7% by weight, it is not preferable because it can act as a factor that increases only the manufacturing cost without further increasing the effect.

The acrylic acid-based anionic water-soluble polymer compound is a major component that forms a thin film together with a film-forming agent. At this time, it is preferable to use an acrylate/C10-30 alkyl acrylate crosspolymer (acrylates/C10-30　alkyl　acrylate　crosspolymer) as the acrylic acid-based anionic water-soluble polymer compound.

This acrylate/C10-30 alkyl acrylate crosspolymer is a crosslinked polymer and can increase the elasticity of the membrane by crosslinking to seal the skin without a gap. In addition, since the acrylate/C10-30 alkyl acrylate crosspolymer is formed based on two acrylate components, it has breathability.

In addition, the acrylic acid-based anionic water-soluble polymer compound increases the viscosity and protects components that are easily oxidized in air. The membrane formed on the skin has an excellent function of retaining moisture and allows air to enter, so it can be used during sleep without skin troubles and irritation.

The acrylic acid-based anionic water-soluble polymer compound is preferably added in an amount of 0.3 to 0.7% by weight of the total weight of the artificial membrane cream composition of the present invention, and more preferably 0.4 to 0.6% by weight.

When the addition amount of the acrylic acid-based anionic water-soluble polymer compound is less than 0.3% by weight, it may be difficult to properly exhibit the above effect. Conversely, when the amount of the acrylic acid-based anionic water-soluble polymer compound exceeds 0.7% by weight, it is not economical because it can act as a factor that only increases the manufacturing cost without further increasing the effect.

Five kinds of multipeptides myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetylhexapeptide-8, SH-polypeptide-11 (sh-polypeptide-) 11) and SH-oligopeptide-1 exhibit high biochemical effects by improving the delivery efficiency of functional components to target cells by using a drug delivery system.

These five multipeptides are active ingredients that exhibit anti-aging and wrinkle-improving effects, and are mixed with the cosmetic ingredients that form the film to form a protein film of similar cosmetic ingredients on the skin.

At this time, myristoyl pentapeptide-11 is preferably added in an amount of 0.5 to 1.5% by weight of the total weight of the artificial membrane cream composition of the present invention, and more preferably 0.8 to 1.2% by weight may be presented.

Acetylhexapeptide-8 is preferably added in an amount of 0.05 to 0.20% by weight of the total weight of the artificial membrane cream composition of the present invention, and more preferably 0.05 to 0.10% by weight may be presented.

SH-polypeptide-11 is preferably added in an amount of 0.00005 to 0.00020% by weight of the total weight of the artificial membrane cream composition of the present invention, more preferably 0.00010 to 0.00015% by weight may be presented.

SH-oligopeptide-1 is preferably added in 0.00005 to 0.00020% by weight of the total weight of the artificial membrane cream composition of the present invention, more preferably 0.00010 to 0.00015% by weight may be presented.

As water, distilled water may be used, preferably deionized distilled water is used.

In addition, the artificial membrane cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to an embodiment of the present invention is in weight %, caprylyl glycol: 0.3 to 0.8%, hexylene glycol glycol): 0.3 ~ 0.7%, ethylhexylglycerin: 0.2 ~ 0.7%, lysine: 0.00001 ~ 0.00020%, proline: 0.00001 ~ 0.00020%, glycine: 0.00001 ~ 0.00020%, Malus domestica fruit cell culture extract: 0.2 ~ 0.8%, citrus grandis (grapefruit) seed extract: 0.1 ~ 0.4%, silk amino acids: 0.05 ~ 0.30 %, fullerenes: 0.01 to 0.20%, and arbutin: may further contain one or more of 0.05 to 0.30%.

Caprylyl glycol acts as a moisturizing agent with antibacterial action, and even when used alone, it exhibits sufficient preservative effect, which can significantly reduce the amount of chemical preservatives mixed, but when used in large amounts, it may adversely affect the stability of the formulation. . Accordingly, caprylyl glycol is preferably added in an amount of 0.3 to 0.8% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.4 to 0.6 vol%.

Hexylene glycol is added as a coupling agent. Such hexylene glycol is preferably added in an amount of 0.3 to 0.7% by weight of the total weight of the artificial film composition of the present invention, and a more preferable range may be 0.4 to 0.6% by weight.

Ethylhexylglycerin acts as a moisturizing agent with antibacterial action and improves skin elasticity. Such ethylhexyl glycerin is preferably added in an amount of 0.2 to 0.7% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.4 to 0.6% by weight.

If the amount of ethylhexyl glycerin is less than 0.2% by weight, the amount of ethylhexyl glycerin is insignificant and it is difficult to properly exhibit the antiseptic effect. On the contrary, when the amount of ethylhexyl glycerin added exceeds 0.7% by weight, the increase in the preservative effect is insignificant compared to the increase amount, and it acts as a factor for reducing the amount of other components, which is not preferable.

Lysine plays a role in moisturizing, cell proliferation, promoting collagen synthesis, and improving skin elasticity and skin wrinkles. This lysine is added together with proline to help produce collagen, helping to manage healthy and elastic skin. Accordingly, lysine is preferably added in an amount of 0.00001 to 0.00020% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.00010 to 0.00015% by weight.

Proline is one of the amino acids that make up a protein, and is biosynthesized from glutamic acid, and is metabolized to glutamic acid in the same process as the reverse reaction of biosynthesis. Such proline plays a role in moisturizing, cell proliferation, promoting collagen synthesis, improving skin elasticity and skin wrinkles. Such proline is preferably added in an amount of 0.00001 to 0.00020% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.00010 to 0.00015% by weight.

Glycine plays a role in moisturizing, cell proliferation, promoting collagen synthesis, improving skin elasticity and skin wrinkles. These glycines are added together with lysine and proline to help produce collagen, helping to manage healthy and elastic skin. Therefore, glycine is preferably added in an amount of 0.00001 to 0.00020% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.00010 to 0.00015% by weight.

Malignant tumor fruit cell culture extract is a plant stem cell extracted from apples grown in Switzerland, and has excellent effects in preventing skin aging and improving wrinkles. The malignant tumor fruit cell culture extract is preferably added in an amount of 0.2 to 0.8% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.4 to 0.6% by weight.

When the addition amount of the malignant tumor fruit cell culture extract is less than 0.2% by weight, it is difficult to properly exhibit the above effect. On the contrary, when the amount of malignant tumor fruit cell culture extract exceeds 0.8% by weight, it is not economical because it can act as a factor that only increases manufacturing cost without further increasing the effect.

Tangerine seed extract has the effect of astringent pores of the skin, elasticity of the skin and soothing skin troubles. The tangerine tree seed extract is preferably added in an amount of 0.1 to 0.4% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.2 to 0.3% by weight.

Silk amino acids may be artificially synthesized or prepared by hydrolyzing silk. Silk amino acids are a mixture of amino acids and are called sericin. Silk amino acids are composed of about 18 amino acids similar to human skin, have excellent skin moisturizing effect, and act to attract skin to prevent wrinkles from forming, restore already formed wrinkles, and block UV rays. These silk amino acids are preferably added in an amount of 0.05 to 0.30% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.1 to 0.2% by weight.

Fullerenes play a role in preventing skin aging. These fullerenes are preferably added in an amount of 0.01 to 0.20% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.05 to 0.10% by weight.

Arbutin has a skin whitening effect. Such arbutin is preferably added in an amount of 0.05 to 0.30% by weight of the total weight of the artificial membrane cream composition of the present invention, and a more preferable range may be 0.1 to 0.2% by weight.

In the artificial film cream composition having excellent moisturizing power and skin penetration effect by the nano-liposome treatment method according to an embodiment of the present invention, a film former, xantan gum, glycerin, cetearyl alcohol , Kaolin, bentonite, cholesterol, lecithin and acrylic acid-based anionic water-soluble polymer compounds act as major ingredients for film formation when applied to the skin.

In addition, myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetyl hexapeptide-8, SH-polypeptide-11 (sh -polypeptide-11), SH-oligopeptide-1, when applied to the skin, acts as an active ingredient to form a breathable protein membrane by assisting the film formation with the main ingredients for film formation.

At this time, the breathable protein membrane is in close contact with the skin to penetrate the active ingredients deep into the skin and suppress moisture loss from the skin.

This will be described in more detail below with reference to the accompanying drawings.

1 is a schematic diagram for explaining an artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method according to an embodiment of the present invention, and FIG. 2 is an active ingredient of the artificial membrane cream composition according to an embodiment of the present invention It is a schematic diagram to explain the skin penetration process.

1 and 2, when the cosmetic ingredient for film formation and the active ingredient are mixed and dissolved at high temperature, stirred and cooled to disperse at high pressure, and then stabilized, the cosmetic ingredient for film formation is added to the active ingredient 140. A low-molecular multilayer nanocapsule 120 that is wrapped and coated is formed.

Accordingly, the artificial membrane cream composition 100 of the present invention collects the active ingredient 140 in the multilayer nanocapsule 120 so that it penetrates to the deep part of the skin 10 without decomposing the weak active ingredient 140. You will be able to.

Here, the cosmetic component for film formation may include sodium acrylate copolymer, xanthan gum, glycerin, cetearyl alcohol, kaolin, bentonite, cholesterol, lecithin, and acrylate/C10-30 alkyl acrylate crosspolymer.

In addition, the active ingredients of the five peptides may include myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetylhexapeptide-8, SH-polypeptide-11, and SH-oligopeptide-1.

At this time, the multi-layer nanocapsule 120 has a structure in which low-molecularized molecules are overlapped to form a layer by layer, so that the active ingredient is collected between the layer and the layer in a special shape of a hollow sphere. These multi-layered nanocapsules 120 are made of a fat-soluble material that is decomposed by heat when applied to the skin 10 of the human body, so that it passes between the cells of the skin 10 and is It melts little by little and the pores open, allowing the active ingredients to be continuously sent deep into the skin (10) for a long time.

In addition, the multilayer nanocapsule 120 is not a synthetic chemical substance, but a natural component made of phospholipids such as cholesterol and lecithin, and is in the form of a lipid double membrane such as a skin cell membrane, so it has a structure quite similar to the skin 10 of the human body. have.

Accordingly, a water-soluble active ingredient that is difficult to penetrate into the skin 10 of the human body is transmitted to the inside of the stratum corneum, and it may be possible to inject a fat-soluble ingredient, which is difficult to mix, to the dermal layer of the skin 10.

In general, when forming a film by applying an artificial film cream composition to the skin of the human body, if the film power is strengthened, a moisturizing agent component is sufficiently supplied and the moisturizing film is completely formed, but when the drying time is delayed or the adhesion to the skin is increased and the film is removed. There are disadvantages of irritation or breaking of the membrane. On the other hand, if the film power is weak, the drying time may be shortened and irritation may be reduced. However, the moisturizing film formation is weakened, and the supply of the moisturizing agent components is insufficient.

However, in the artificial film composition according to an embodiment of the present invention, the acrylic acid-based anionic water-soluble polymer compound, acrylate/C10-30 alkyl acrylate crosspolymer, is combined with sodium acrylate copolymer (or octofluoropentyl methacrylate). By forming a breathable protein film that is a transparent silicone-type skin protective film on the surface of the skin, it keeps the skin moisturized, and liposomes using cholesterol, lecithin, etc. act as multi-layer nanocapsules to maintain the stability of the formulation without elution of active ingredients. It helps to be absorbed into the skin.

As a result, in the artificial membrane cream composition according to an embodiment of the present invention, the breathable protein membrane formed on the skin acts as a hermetic therapy, so that the active ingredient effectively and continuously penetrates deep into the skin throughout the sleep period to prevent moisture and oil loss from the skin.

Therefore, the artificial membrane cream composition according to an embodiment of the present invention can exhibit an immediate effect of providing sufficient nutrition and moisturizing effect to the skin without penetrating the breathable protein membrane into the skin of the human body, correcting skin sagging, and maintaining elasticity. .

Accordingly, according to the present invention, when the artificial membrane cream composition is applied to the skin of the human body and dried, a breathable protein membrane that is perfectly adhered to the skin is formed to inhibit moisture evaporation from the skin of the human body, and fundamentally restore the damaged skin barrier to treat atopy. effective.

In addition, the present invention forms a transparent silicone-type skin protective film by combining an acrylate/C10-30 alkyl acrylate crosspolymer and a sodium acrylate copolymer (or octofluoropentyl methacrylate). When applied to the skin of the human body and applied on it, it can exert a booster effect that radiates brightly like water-glossy skin.

Example

Hereinafter, the configuration and operation of the present invention will be described in more detail through preferred embodiments of the present invention. However, this is presented as a preferred example of the present invention and cannot be construed as limiting the present invention in any sense.

Contents not described herein can be sufficiently technically inferred by those skilled in the art, and thus description thereof will be omitted.

1. Manufacture of artificial membrane cream composition

The artificial membrane cream compositions according to Examples 1 to 3 and Comparative Examples 1 to 2 were prepared with the compositions shown in Table 1. At this time, only for the artificial membrane cream compositions according to Examples 1 to 3, five kinds of peptides myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetylhexapeptide-8, SH-polypeptide-11 and SH- Oligopeptide-1 was collected in the interior of the multilayer nanocapsule by nano-liposome treatment.

[Table 1] (Unit: wt%)

2. Property evaluation

Table 2 shows the physical property evaluation results of the artificial membrane cream compositions prepared according to Examples 1 to 3 and Comparative Examples 1 to 2.

1) Skin moisturizing power

In order to check the skin moisturizing power, 10 g of the artificial membrane cream composition prepared according to Examples 1 to 3 and Comparative Examples 1 to 2 was applied to the arm of 10 women in their 50s, and then 1 hour and 5 hours later, the skin was The moisture content was measured respectively.

At this time, the moisture meter measured the amount of moisture in the skin's epidermis using a sensor, and calculated the amount of moisture by calculating the amount of moisture to check the moisture level, and the unit was AU (arbitary) designated by its own standard. Denoted as. First, a numerical value that appears when the sensor of the moisture meter is pressed lightly after being in close contact with the skin surface to be measured is displayed.

[Table 2]

As shown in Table 2, it can be seen that the artificial membrane cream compositions prepared according to Examples 1 to 3 have significantly better moisturizing lasting power compared to the artificial membrane cream compositions prepared according to Comparative Examples 1 to 2.

As can be seen from the above experimental results, the artificial film cream compositions prepared according to Examples 1 to 3 are acrylate/C10-30 alkyl acrylate crosspolymer and sodium acrylate copolymer (or octofluoropentyl methacrylate). It was confirmed that the breathable protein membrane was formed by being added together to show excellent moisturizing power.

2) Skin wrinkle improvement

In order to confirm the effect of improving skin wrinkles, the artificial film cream composition prepared according to Examples 1 to 3 and Comparative Example 1 was applied to 50 women in their 40s to 50s once a day for 1 month before going to bed. After 1 month, a questionnaire survey was conducted to the subjects about the degree of wrinkle improvement.

In the questionnaire survey for the subject, the degree of improvement was scored based on the following criteria compared to before use, and then the average value was calculated.

◎ Almost no improvement effect: 5 ~ 6

◎ Some improvement effect: 7 ~ 8

◎ Great improvement: 9 ~ 10

[Table 3]

As shown in Table 3, it was confirmed that the artificial membrane cream composition prepared according to Examples 1 to 3 had a significantly better effect of improving skin wrinkles compared to the artificial membrane cream composition prepared according to Comparative Examples 1 to 2.

As can be seen from the above experimental results, in the artificial film cream composition prepared according to Examples 1 to 3, the acrylate/C10-30 alkyl acrylate crosspolymer is a sodium acrylate copolymer (or octofluoropentyl methacrylate). By combining with the skin, it forms a breathable protein film that is a transparent silicone-type skin protective film on the outside of the skin to keep the skin moisturized, and the five kinds of peptides, the active ingredients in the multilayer nanocapsules, are continuously absorbed into the skin of the human body without elution and wrinkles. It is believed that it exhibited an excellent effect on improvement.

In the above, the embodiments of the present invention have been described mainly, but various changes or modifications can be made at the level of those of ordinary skill in the art to which the present invention pertains. Such changes and modifications can be said to belong to the present invention as long as they do not depart from the scope of the technical idea provided by the present invention. Accordingly, the scope of the present invention should be determined by the claims set forth below.

10: human skin
100: artificial film cream composition
120: multi-layer nanocapsules
140: active ingredient

Claims (7)

In% by weight, caffeine: 0.5 to 12%, sodium hyaluronate: 4 to 6%, aloe barbadensis leaf juice: 3 to 7%, carbomer: 1.5 to 3.5%, film forming agent: 1 to 3%, xantan gum: 0.5 to 2.5%, glycerin: 0.5 to 1.5%, cetearyl alcohol: 0.5 to 1.5%, kaolin ( kaolin): 0.1 ~ 1.0%, bentonite: 0.1 ~ 1.0%, cholesterol: 0.2 ~ 0.8%, lecithin: 0.3 ~ 0.7%, acrylic acid-based anionic water-soluble polymer compound: 0.3 ~ 0.7% , Myristoyl pentapeptide-11: 0.5 ~ 1.5%, myristoyl pentapeptide-8: 0.3 ~ 0.6%, acetyl hexapeptide-8 : 0.05 ~ 0.20%, SH-polypeptide-11 (sh-polypeptide-11): 0.00005 ~ 0.00020%, SH-oligopeptide-1 (sh-oligopeptide-1): 0.00005 ~ 0.00020% and the rest of water,
The myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetylhexapeptide-8, SH-polypeptide-11, and SH-oligopeptide-1 were incorporated into the interior of a multilayer nanocapsule by nano-liposome treatment. An artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method characterized in that it is collected.
The method of claim 1,
The film forming agent
An artificial film cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method, characterized in that it is sodium acrylates copolymer or octofluoropentyl methacrylate.
The method of claim 1,
The acrylic acid-based anionic water-soluble polymer compound
An artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method, characterized in that it is an acrylate/C10-30 alkyl acrylate crosspolymer.
The method of claim 1,
The multilayer nanocapsule is
An artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method, characterized in that it is made of a fat-soluble material that is decomposed by heat.
The method of claim 1,
The film forming agent, xantan gum, glycerin, cetearyl alcohol, kaolin, bentonite, cholesterol, lecithin and acrylic acid-based anionic An artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method, characterized in that the water-soluble polymer compound acts as a major component for film formation when applied to the skin.
The method of claim 1,
The myristoyl pentapeptide-11, myristoyl pentapeptide-8, acetyl hexapeptide-8, SH-polypeptide-11 (sh- polypeptide-11), SH-oligopeptide-1 is a nano-liposome treatment method characterized in that when applied to the skin, it acts as an active ingredient to form a breathable protein membrane along with the main ingredient for film formation. An artificial membrane cream composition having excellent moisturizing power and skin penetration effect.
The method of claim 1,
The artificial membrane cream composition
By weight%, caprylyl glycol: 0.3 ~ 0.8%, hexylene glycol: 0.3 ~ 0.7%, ethylhexylglycerin: 0.2 ~ 0.7%, lysine: 0.00001 ~ 0.00020%, proline: 0.00001 to 0.00020%, glycine: 0.00001 to 0.00020%, malus domestica fruit cell culture extract: 0.2 to 0.8%, citrus grandis (grapefruit) seed extract): 0.1 to 0.4%, silk amino acids: 0.05 to 0.30%, fullerenes: 0.01 to 0.20%, and arbutin: 0.05 to 0.30%. An artificial membrane cream composition having excellent moisturizing power and skin penetration effect by a nano-liposome treatment method, comprising.

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