JP2018052904A - External composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external composition that enhances a skin barrier function, thereby preventing the deterioration of a skin function and improving discomfort symptoms such as an itch and an inflammation.SOLUTION: An external composition contains a higher fatty acid, a higher fatty acid salt, and a higher alcohol. Preferably, the content of the higher fatty acid is 5-25 wt.%, the content of the higher fatty acid salt is 2-10 wt.%, and the content of the higher alcohol is 0.5-8 wt.%.SELECTED DRAWING: None

Description

  The present invention relates to a composition for external use.

  The skin layer is a tissue having a thickness of only 20 μm, and has a barrier function to protect the living body from external stimuli such as ultraviolet rays and allergens. When the barrier function of the epidermis layer breaks down, the external stimulus enters the skin and causes symptoms such as rough skin, blemishes, wrinkles, reduced skin, and sagging skin, and itching and inflammation caused by allergen entry. Causes discomfort. As a result, the function of the skin is lowered, resulting in a vicious circle leading to further deterioration of the barrier function.

  By enhancing the barrier function, it is possible to prevent a decrease in skin function and to improve unpleasant symptoms such as itching and inflammation. Conventionally, a skin barrier function enhancer or the like by a specific plant extract has been proposed for such a problem, but there is a problem that it itself becomes an allergen, and it cannot be said that it has a sufficient effect.

Japanese Unexamined Patent Publication No. 2016-23167 JP 2003-292432 A

  An object of this invention is to provide the composition for external use which has the effect | action which enhances a skin barrier function.

  The inventors of the present invention have been diligently studied to achieve the above object, and unexpectedly found that the saponified product conventionally used as soap has an action of enhancing the barrier function of the skin. It has been found that by using a higher alcohol in combination with this, the saponified product has a further enhanced skin barrier function enhancing action, and a composition having an even better skin barrier function enhancing action can be obtained.

  The present invention has been completed based on this finding, and has the following embodiments.

(I) External composition (I-1) An external composition containing a higher fatty acid, a higher fatty acid salt, and a higher alcohol.
(I-2) The content of higher fatty acid is 5 to 25% by weight, the content of higher fatty acid salt is 2 to 10% by weight, and the content of higher alcohol is 0.5 to 8% by weight. 1) The composition for external use as described.
(I-3) The higher fatty acid and the higher fatty acid of the higher fatty acid salt are the same or different and are saturated or unsaturated fatty acids having 14 to 18 carbon atoms, as described in (I-1) or (I-2) A composition for external use.
(I-4) The composition for external use according to any one of (I-1) to (I-3), wherein the higher alcohol is a saturated or unsaturated monohydric alcohol having 14 to 18 carbon atoms.
(I-5) The composition for external use according to any one of (I-1) to (I-4), wherein the saponification rate is 20 to 40%, preferably about 30%.
(I-6) The composition for external use described in any one of (I-1) to (I-5), which further contains a liquid saturated glycol.
(I-7) The composition for external use as described in (I-6) whose content of liquid saturated glycol is 0.5 to 60 weight%.
(I-8) The liquid saturated glycol is at least one selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol, (I-6) or (I-7) The composition for external use described in any one of.
(I-9) The composition for external use described in any one of (I-1) to (I-8), which is an O / W type emulsion composition.
(I-10) The composition for external use described in any one of (I-1) to (I-9), which is a cosmetic.

(II) Method for producing composition for external use (II-1) Any one of (I-1) to (I-10) comprising a step of mixing at least a higher fatty acid, an alkali and a higher alcohol as raw materials A method for producing a composition for external use as described above.
(II-2) The amount of higher fatty acid is 8 to 30% by weight, the amount of alkali is 0.2 to 5% by weight, and the content of higher alcohol is 0.5 to 8% by weight, (II- 1) The manufacturing method as described.
(II-3) The production method according to (II-1) or (II-2), wherein the amount of alkali added is 4 to 8 parts by weight with respect to 100 parts by weight of higher fatty acid.
(II-4) The higher fatty acid and the higher fatty acid of the higher fatty acid salt are the same or different, and are saturated or unsaturated fatty acids having 14 to 18 carbon atoms. (II-1) to (II-3) The manufacturing method described in any one.
(II-5) The production method according to any one of (II-1) to (II-4), wherein the higher alcohol is a saturated or unsaturated monohydric alcohol having 14 to 18 carbon atoms.
(II-6) The production method according to any one of (II-1) to (II-5), which is a method for producing a composition for external use having a saponification rate of 20 to 40%, preferably about 30%.
(II-7) The production method according to any one of (II-1) to (II-6), further comprising a step of blending a liquid saturated glycol.
(II-8) The manufacturing method as described in (II-7) whose compounding quantity of liquid saturated glycol is 0.5 to 60 weight%.
(II-9) The liquid saturated glycol is at least one selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol, (II-7) or (II-8) The manufacturing method described in any one of.
(II-10) The production method according to any one of (II-1) to (II-9), wherein the external composition is an O / W emulsion composition and has an emulsification step.

(III) Cosmetic method (III-1) A cosmetic method comprising a step of applying the external composition described in any of (I-1) to (I-10) above to the skin of a subject.
(III-2) The cosmetic method according to (III-1), wherein the cosmetic method is a method for improving skin symptoms caused by a decrease in skin barrier function.
(III-3) The cosmetic method described above is a cosmetic method for improving skin symptoms caused by reduced skin barrier function, selected from the group consisting of rough skin, spots, wrinkles, reduced firmness and sagging skin (III -1) or the cosmetic method described in (III-2).

  According to the composition for external use of the present invention, the function can be improved and improved by applying to the skin having a lowered skin barrier function. As a result, moisture transpiration from the skin can be suppressed, skin moisture retention can be improved, and symptoms such as rough skin can be improved. In addition, the skin barrier function enhancing action of the present invention can suppress the entry of external stimuli such as allergens and ultraviolet rays, thereby suppressing and improving wrinkles (fine wrinkles, large wrinkles), reduction of elasticity and skin sagging. It is also possible to reduce discomfort such as itchiness and inflammation caused by allergens.

(I) External Composition The external composition of the present invention is characterized by containing a higher fatty acid, a higher fatty acid salt, and a higher alcohol.

(A) Higher fatty acid In the present invention, the higher fatty acid is not limited, but is preferably a saturated or unsaturated fatty acid having 14 to 18 carbon atoms. Such fatty acids include myristic acid (14: 0), pentadecylic acid (15: 0), palmitic acid (16: 0), palmitoleic acid (16: 1), margaric acid (17: 0), stearic acid (18: 0), oleic acid (18: 1), vaccenic acid (18: 1), linoleic acid (18: 2), linolenic acid (18: 3), and eleostearic acid (18: 3) . The numbers in parentheses after the chemical names indicate the number of carbon atoms of the fatty acid and the latter the number of double bonds. In addition to the skin barrier function enhancing action, from the viewpoint of good usability, a saturated fatty acid having 16 to 18 carbon atoms is more preferable, and palmitic acid, stearic acid, and margaric acid are particularly preferable.

  Although the content rate of these higher fatty acids in the composition for external use of this invention is not restrict | limited, Usually, it is about 5 to 25 weight%. Preferably it is 7 to 20 weight%, More preferably, it is 7 to 11 weight%.

(B) Higher fatty acid salt As described later, higher fatty acid salt is produced by alkali reacting with higher fatty acid used as a raw material in the production process. It may be present and its origin is not particularly limited.

  The higher fatty acid constituting the higher fatty acid salt is not limited, but is preferably a saturated or unsaturated fatty acid having 14 to 18 carbon atoms. Such fatty acids include myristic acid (14: 0), pentadecylic acid (15: 0), palmitic acid (16: 0), palmitoleic acid (16: 1), margaric acid (17: 0), as in the above higher fatty acids. ), Stearic acid (18: 0), oleic acid (18: 1), vaccenic acid (18: 1), linoleic acid (18: 2), linolenic acid (18: 3), and eleostearic acid (18: 3). In addition to the skin barrier function enhancing action, from the viewpoint of good usability, a saturated fatty acid having 16 to 18 carbon atoms is more preferable, and palmitic acid, stearic acid, and margaric acid are particularly preferable.

  Examples of higher fatty acid salts include alkali metal salts (fatty acid sodium, fatty acid potassium, etc.) of the above higher fatty acids, alkaline earth metal salts (eg, fatty acid magnesium, fatty acid calcium, fatty acid barium, etc.), and ammonia salts (fatty acid ammonium). , Higher fatty acids and amines, hydroxylamines, imines, guanidines, amine oxides, alkanolamines, alkoxylated amines, and alkylamines (diethanolamine, triethanolamine, isopropanolamine, diisopropanolamine, Triisopropanolamine, aminobutanol, aminoethylpropanediol, aminomethylpropanol, aminomethylpropanediol, isopropylamine, methylethanolamine, diisopropyl Min, dipropylenetriamine, glucamine, N- methylglucamine, morpholine, tromethamine), cocamine compounds, soyamine acids, oleamine acids, stearamine compounds can be exemplified the reaction product of an organic amine such as Kuoteruniumu class. Preferred are alkali metal salts or alkaline earth metal salts of fatty acids, and more preferred are fatty acid sodium salts or fatty acid potassium which are alkali metal salts of fatty acids.

  Although the content rate of these higher fatty acid salts in the composition for external use of this invention is not restrict | limited, Usually, it is about 2 to 10 weight%. Preferably it is 2-9 weight%, More preferably, it is 3-9 weight%.

(C) Higher alcohol In the present invention, the higher alcohol is not limited, but is preferably a saturated or unsaturated monovalent alcohol having 14 to 18 carbon atoms. Such higher alcohols include myristyl alcohol, pentadecyl alcohol, cetanol, cetosallyl alcohol, palmitoleyl alcohol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, and lisinoleyl. Mention may be made of fatty alcohols such as alcohols or synthetic alcohols. From the viewpoint of good usability in addition to the skin barrier function enhancing action, it is preferably a saturated monohydric alcohol having 16 to 18 carbon atoms, particularly preferably cetanol, cetosallyl alcohol, palmitoleyl alcohol, 1-hepta. Decanol, stearyl alcohol, isostearyl alcohol, oleyl alcohol.

  Although the content rate of these higher alcohols in the composition for external use of this invention is not restrict | limited, Usually, it is about 0.5 to 8 weight%. Preferably it is 1-8 weight%, More preferably, it is 1-3 weight%.

(D) Liquid saturated glycol The composition for external use of the present invention may contain a liquid saturated glycol. The liquid saturated glycol acts as a moisturizer or softener on the skin. Examples of such liquid saturated glycol include, but are not limited to, at least one selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol. Preferred are propylene glycol, dipropylene glycol and polyethylene glycol, and more preferred are propylene glycol and polyethylene glycol. Although it does not restrict | limit, the range of 0.5 to 60 weight% can be mentioned as content rate of the liquid saturated glycol in the composition for external use of this invention. Preferably 1 to 60 weight%, More preferably, 5 to 60 weight% can be mentioned.

(E) Other components The above-described components (A) to (C) or the above-mentioned (A), as long as the composition for external use of the present invention does not hinder the effect of the present invention to exert a skin barrier function enhancing action. In addition to the component (D), other components may be contained. Examples of such components include humectants, thickeners, surfactants, oily components, antioxidants, antiseptic / bactericides, powder components, fragrances, pigments, water, and the like.

  Examples of humectants include, but are not limited to, glycerin; saccharides such as sorbitol, xylitol, and trehalose; sodium pyrrolidonecarboxylate, lactic acid bacteria fermented rice, hyaluronic acid and its derivatives (for example, hyaluronic acid having a molecular weight of several thousand to several million or its Salts, acetylated hyaluronic acid, propylene glycol hyaluronate, hydroxypropyltrimonium hyaluronate), mucopolysaccharides (eg chondroitin and its derivatives, heparin and its derivatives), elastin and its derivatives, collagen and its derivatives, hydrolysis Silk protein, lactic acid, urea, higher fatty acid octyldodecyl, phytosterol, soybean phospholipid, cholesteryl isostearate, seaweed extract, collagen derived from seafood and its derivatives, various amino acids and their Et derivatives (such as trimethyl glycine, etc.), luffa extract, Byakkyuu extract, soybean milk fermented liquor, natto extract, and the like rice-derived extract and fermented product.

  Thickeners are not limited, but include, for example, components derived from brown algae, green algae, or red algae such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as beech extract, pectin, locust bean gum, aloe polysaccharide; xanthan gum, tragacanth gum Gums such as guar gum; cellulose derivatives such as carboxymethyl cellulose and hydroxyethyl cellulose; synthetic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer; polyglutamic acid and its derivatives; glucosyl trehalose And sugar compounds mainly composed of hydrolyzed hydrogenated starch.

  The surfactant is not limited, but for example, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene cured Nonionic surfactants such as castor oil and polyoxyethylene sorbitol fatty acid ester; fatty acid salt, alkyl sulfate, alkylbenzene sulfonate, polyoxyethylene alkyl ether sulfate, polyoxyethylene fatty amine sulfate, polyoxyethylene alkylphenyl Ether sulfate, polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether Anionic surfactants such as ruphosphates; quaternary ammonium salts, primary to tertiary aliphatic amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethyls Cationic surfactants such as imidazolinium salt, N, N-dialkylmorphonium salt, polyethylene polyamine fatty acid amide salt; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N And amphoteric surfactants such as -trialkyl-N-alkyleneammoniocarboxybetaine and N-acylamidopropyl-N ', N'-dimethyl-N'-β-hydroxypropylammoniosulfobetaine. In addition, stevia derivatives such as enzyme-treated stevia, lecithin and its derivatives, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (wheat, beans, millet, etc.), beech extract etc. You can also

  Examples of the oil component include, but are not limited to, hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, and squalane.

  Antioxidants include, but are not limited to, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives, vitamin C (ascorbic acid) and its derivatives, ubidecaquinone (ubiquinone), rutin, rutin glucoside, white Examples of the extract include a coconut extract, a rice extract, a purple extract, a birch extract, a hamamelis extract, a oolong tea extract, a black bean hydrolyzed extract, a peony extract, a beech cucumber extract, and a sorghum extract.

  Examples of the antiseptic / bactericidal agent include, but are not limited to, paraoxybenzoates such as urea, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate, phenoxyethanol, dichlorophene, hexachlorophene, hydrochloric acid Examples include chlorhexidine, benzalkonium chloride, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazolidene urea), dry bark, propolis extract, and methylisothiazolinone.

  Examples of powder components include, but are not limited to, sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, 6- or 12-nylon. There are powder, polyethylene powder, silk powder, cellulosic powder, powder of cereals (rice, wheat, corn, millet, etc.), powder of beans (soybean, red beans, etc.).

  Further, if necessary, other physiologically active ingredients (fibroblast activator, whitening agent, skin aging prevention / roughness improving agent, etc.) may be blended within a range not impeding the effects of the present invention.

  The fibroblast activator is not limited, but for example, bilberry leaf extract, polyamine, aloe extract, cuckoo extract, chlorella extract, placenta extract, sugar maple tree sap, royal jelly, yeast extract, mucopolysaccharide fluid, dairy extract, soybean extract, Whey etc. can be mentioned.

  Examples of the whitening agent include, but are not limited to, t-cycloamino acid derivatives, kojic acid and its derivatives, vitamin C (ascorbic acid) and its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, nicotinic acid and its derivatives, resorcinol Derivatives, tranexamic acid and derivatives thereof, 4-methoxysalicylic acid potassium salt, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), 4-HPB (rhodenol, 4- (4-hydroxyphenyl)- 4-butanol)), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acid, AMP (adenosine monophosphate, adenosine monophosphate), placenta extract, suha akuhi extract, yukinoshita extract, rice bran Extract or its hydrolyzate, white coconut extract Or hydrolyzate thereof, fermented white coconut, peony extract or hydrolyzate thereof, lactic acid bacteria fermented rice, lactic acid bacteria fermented rice, lactic acid bacteria fermented cereals (wheat, legumes, millet), murasakixikibu extract, lotus seed extract Or hydrolyzate thereof, fermented lotus seed, extract of party ginseng, pearl hydrolyzate, fermented pearl seed, fermented royal jelly, fermented sake lees, Pandanus amaryllifolius Roxb. Examples thereof include an extract of a sea flava (Arcangelicia flava Merrilli) and a chamomile extract.

  The skin aging prevention / roughness improving component is not limited, for example, coral grass extract, rice leaf extract or hydrolyzate thereof, eggplant (water eggplant, long eggplant, Kamo eggplant, rice eggplant etc.) extract or Hydrolyzate thereof, extract of seaweed such as catamen giraffe, extract of marine flowering plant such as sea eel, jellyfish water, rice extract or hydrolyzate thereof, rice fermentation extract, germinated rice extract or hydrolyzate thereof Germinated rice fermented product, black bean extract or hydrolyzate thereof, collagen derived from animal or fish and derivatives thereof, elastin and derivatives thereof, intercellular lipids such as ceramide, glycyrrhizic acid and derivatives thereof (dipotassium salt, etc.), t- Cycloamino acid derivative, vitamin A and its derivative, t-cycloamino acid derivative, vitamin A and its derivative, vitamin E and its derivative (d, l-α-toco Sodium eryl phosphate), allantoin, α-hydroxy acids, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, coenzyme Q-10, α-lipoic acid, ergothioneine, allantoin, diisopropylamine dichloroacetate, γ-amino- β-hydroxybutyric acid, gentian extract, licorice extract, carrot extract, aloe extract, beetle extract, anaosa extract, zizyphus joazeiro extract, beech extract, beetle aloe extract, mannenrou extract, ginkgo biloba Extract, Horsetail extract, Safflower extract, Panax ginseng extract, Horseshoe extract, Jasmine extract, Astragalus extract, Mango extract, Cherimoya extract, Mangosteen extract, Tabebuia impetigenosa Extracts, yeast extract, eggshell membrane extract protein, deoxyribonucleic acid potassium salt, lotus seed fermented liquid, pollen cargo extract and the like can be mentioned.

  As will be described later, the composition for external use of the present invention is produced using a higher fatty acid and an alkali as raw materials, and as a result, contains a part of the higher fatty acid in a saponified state. The saponification rate of the composition for external use of the present invention is not limited, but can be in the range of 20 to 40%. Preferably it is 20 to 35%, more preferably 25 to 35%, particularly preferably about 30%.

  The composition for external use of the present invention comprises the above components (A) to (C) and, if necessary, the component (D) and / or the component (E), and is mixed into a desired shape (solid, semi-solid). Shapes [gels, creams, ointments, etc.] and liquids [emulsions, lotions, etc.]). An emulsion, particularly an O / W emulsion, is preferred, and a creamy external composition can be more preferably prepared. The external composition may be included in any category of pharmaceuticals, quasi drugs, and cosmetics. Preferred are quasi-drugs for external use and cosmetics, and more preferred are cosmetics.

  Although it does not restrict | limit as a form as a pharmaceutical for external use or a quasi-drug, For example, a cream, an ointment, a plaster, a poultice, a lotion, an emulsion, a liquid, an aerosol, etc. can be mentioned. Creams and emulsions are preferred. Although it does not restrict | limit as a form as cosmetics, For example, as a skin care cosmetics, a lotion, a cosmetic liquid, a pack, a massage cream, an emulsion, a moisture cream, a vanishing cream, a cleansing cream, a lip balm etc. can be mentioned. Massage cream, milky lotion, moisture cream, burnishing cream and cleansing cream are preferred.

(II) Manufacturing method of composition for external use The composition for external use of the present invention containing at least the components (A) to (C) described above mixes at least higher fatty acids, alkalis and higher alcohols as raw materials. It can be prepared through a process.

  The kind of higher fatty acid and higher alcohol used here is as described in the above (I), and the above description can be used.

  As the amount of the higher fatty acid used in the production, as described above, the proportion of the higher fatty acid contained in the external composition after preparation is usually about 5 to 25% by weight, preferably 7 to 20% by weight, more preferably The ratio is 7 to 11% by weight, and the saponification ratio in that case is 20 to 40%, preferably 20 to 35%, more preferably 25 to 35%. It is not something. When the total amount of production raw materials is 100% by weight, the proportion of higher fatty acids used can usually be 8 to 30% by weight. Preferably it is 10-30 weight%, More preferably, it is 10-15 weight%.

  The amount of higher alcohol used in the production is not limited, but when the total amount of production raw materials is 100% by weight, usually about 0.5 to 8% by weight is mentioned as described in (I). Can do. Preferably it is 1-8 weight%, More preferably, it is 1-3 weight%.

  The alkali used for the production is a substance that exhibits a pH of 7 or more when it is made into an aqueous solution, and is a substance that reacts with the higher fatty acid to produce the above-mentioned higher fatty acid salt as a saponified product.

  The alkali includes both inorganic alkalis and organic alkalis. Examples of the inorganic alkali include alkali metal or alkaline earth metal hydroxide salts (for example, sodium hydroxide, potassium hydroxide, magnesium hydroxide, calcium hydroxide, etc.), alkali metal carbonates or bicarbonates ( For example, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate), alkali metal phosphates (eg, sodium phosphate, potassium phosphate), ammonia inorganic salts (eg, ammonium hydroxide, ammonium phosphate, carbonic acid) Or ammonium bicarbonate). Examples of the organic alkali include amines, hydroxylamines, imines, guanidines, amine oxides, alkanolamines, alkoxylated amines, and alkylamines (diethanolamine, triethanolamine, isopropanolamine, diisopropanolamine). , Triisopropanolamine, aminobutanol, aminoethylpropanediol, aminomethylpropanol, aminomethylpropanediol, isopropylamine, methylethanolamine, diisopropylamine, dipropylenetriamine, glucamine, N-methylglucamine, morpholine, tromethamine), Examples include cocamines, soiamines, oleamines, stearamines, quaterniums and the like. An inorganic alkali is preferable. More preferred are alkali metal or alkaline earth metal hydroxide salts, alkali metal carbonates, bicarbonates, or phosphates, with alkali metal hydroxide salts being particularly preferred.

  Although it does not restrict | limit as an amount of the alkali used for manufacture, When the total amount of a manufacturing raw material is 100 weight%, about 0.5 to 5 weight% can be mentioned normally. Preferably it is 0.5 to 2 weight%, More preferably, it is 0.6 to 2 weight%.

  Further, the ratio of the alkali to 100 parts by weight of the higher fatty acid used as a production raw material is not limited, but the saponification rate is 20 to 40%, preferably 20 to 35%, more preferably 25 to 35%. Although it is not limited as long as it is limited, specifically 0.5 to 5 parts by weight, preferably 0.5 to 2 parts by weight, and more preferably 0.6 to 2 parts by weight. be able to.

  Furthermore, when the composition for external use of the present invention contains liquid saturated glycol and / or other optional components as other components, the composition for external use of the present invention contains liquid saturated glycol and / or other optional components in addition to the above components. Manufactured by blending. The type of the liquid saturated glycol is as described above, and the amount thereof can usually be about 0.5 to 60% by weight when the total amount of the raw materials for production is 100% by weight. Preferably it is 1 to 60 weight%, More preferably, it is 5 to 60 weight%.

  The production method of the present invention basically has a step of blending and mixing the above components as raw materials as described above, more specifically, the shape of the composition for external use to be produced. (Solid, liquid, semi-solid), formulation (cream, ointment, plaster, pap, lotion, emulsion, liquid, aerosol) and its use (pharmaceuticals, quasi drugs and cosmetics) It can be carried out according to standard methods. A preferred embodiment of the composition for external use of the present invention is an emulsion, more preferably a cream-like, particularly an O / W-type cream external-use composition, and therefore preferably an emulsion, more preferably a cream-like, especially O / W. According to the manufacturing method of a type cream, it can prepare through an emulsification process.

  The emulsification step can be carried out according to a conventional method such as heating the raw material to a predetermined temperature and then emulsifying under a predetermined condition using a mixer such as a homogenizer, a homomixer, or a stirrer.

(III) Cosmetic method The present invention relates to a cosmetic method in which the above-described external composition of the present invention is applied to a subject having a reduced skin barrier function to enhance and improve the subject's skin barrier function. Note that the method targeted by the present invention is a cosmetic method, not a treatment method for humans.

  Although the cause in particular of a skin barrier function fall is not restrict | limited, For example, aging or ultraviolet irradiation can be mentioned. Decreased skin barrier function due to aging or UV irradiation increases skin moisture transpiration (TEWL), leading to skin deterioration symptoms such as skin dryness, wrinkles (dry wrinkles, dermis wrinkles), sagging skin and reduced firmness. To do.

  The subject is not limited as long as the skin barrier function is lowered or suspected to be lowered, and preferably is a person having symptoms of skin deterioration due to aging or ultraviolet irradiation, preferably due to aging Those who have skin deterioration symptoms (skin aging symptoms). In general, if both men and women are over 30 years old, there is a possibility of becoming the subject concerned. Preferably it is 40 years old or more, More preferably, it is 45 years old or more, More preferably, it is 50 years old or more.

  The composition for external use of the present invention varies depending on its form, but when it has a form such as a plaster, ointment, cream, liniment, lotion, milky lotion, liquid, aerosol, etc., the topical pharmaceuticals, quasi drugs and cosmetics are subjects. Can be used by applying or spraying to the skin of the desired site. Moreover, when external medicine, a quasi-drug, and cosmetics have the form of a poultice, it can be used by sticking the external medicine, a quasi-drug, and a cosmetic to the skin of a desired part of a subject. Application to the skin may be performed once or a plurality of times a day, and examples thereof include a method of applying in the morning and evening (before going to bed). Thus, it is possible to suppress (prevent) or improve the occurrence of skin deterioration symptoms (particularly skin aging symptoms) associated with a decrease in the skin barrier function by aging or ultraviolet irradiation.

  Hereinafter, the present invention will be described based on experimental examples and examples. However, the experimental examples and examples are examples of the present invention, and the present invention is not limited to these experimental examples and examples.

Experimental Example 1 Evaluation of Transepithelial Water Evaporation (TEWL) Transepithelial moisture by applying a composition for external use on skin (cream) (Examples 1 to 4 and Comparative Example 1) having the composition shown in Table 2 to human skin The amount of transpiration was measured, and the skin barrier function enhancing action was evaluated.

(1) Preparation of test sample (external preparation for skin) Regarding the compositions described in Table 2, for Examples 1 to 4, first, the components of Phase A described in Table 1 are taken at the ratio described in Table 1 and heated to 80 ° C. . Next, the components of phase B are taken at the ratios shown in Table 1 and heated to 80 ° C. Next, the B phase component mixture is added to the A phase component mixture and stirred. Next, this was stirred while cooling to 30 ° C. (natural cooling) to prepare an emulsion (cream) (test sample (external composition for skin)) having the composition shown in Table 2.

  On the other hand, in Comparative Example 1, a carboxyvinyl polymer was added while stirring water at a ratio described in Table 1, and the mixture was further stirred, and glycerin was added thereto to prepare a creamy test sample (external composition for skin). All the preparation steps of Comparative Example 1 were performed at room temperature.

(2) Experimental method According to the following procedure, the transepithelial water transpiration (TEWL) of the skin test site was measured before and after application of the test sample (Examples 1 to 4, Comparative Example 1), and the skin barrier of the test sample was measured. The function enhancing action was evaluated.
(I) The TEWL of the inner side of the upper arm (test site) of a human (n = 17) is measured with a portable closed chamber type moisture transpiration measuring device (VAPO SCAN AS-VT100RS: manufactured by Asahi Technolab Co., Ltd.).
(Ii) A non-woven fabric (15 mm × 15 mm) is impregnated with a 4% aqueous solution of SDS, which is applied to the test site for 30 minutes and then peeled off. This is repeated for 4 days to roughen the skin at the test site.
(Iii) After 4 days, the TEWL of the test site is measured again.
(Iv) Apply an appropriate amount (about 0.1 g / time) of the test sample (Examples 1 to 4, Comparative Example 1) twice a day (after getting up in the morning and bathing at night) for 1 week. .
(V) One week after the start of application, TEWL of the test site is measured again.

  For comparison, TEWL was also measured after the end of the experiment in the non-treated area where the test sample was not applied to the test site and left to stand for 1 week after the treatment of (ii) above (untreated group).

(3) Judgment method The TEWL value after completion of the treatment group for each test sample and the TEWL value after completion of the untreated group are statistically processed to determine whether there is a significant difference at a significance level of 5% (signed by Wilcoxon) Rank sum test (corresponding t-test).

(4) Experimental results The results are shown in Table 2.

  A case where there was a significant difference was indicated as ◯, and a case where there was no significant difference was indicated as ×.

  As shown in Table 2, it was found that the external composition for skin (Examples 1 to 4) comprising the composition of the present invention has a strong effect of improving and enhancing the barrier function of the skin.

Formulation Example An external composition for skin (cream) having the composition described in Table 4 was prepared. Specifically, first, the components of the phase A described in Table 3 are taken at the ratio shown in Table 3 and heated to 80 ° C. Next, the components of phase B are taken at the ratios shown in Table 3 and heated to 80 ° C. Next, the B phase component mixture is added to the A phase component mixture and stirred. Next, the mixture was stirred while cooling to 30 ° C. (natural cooling) to prepare an emulsion (cream) having the composition shown in Table 4.

Claims (6)

  A composition for external use containing a higher fatty acid, a higher fatty acid salt, and a higher alcohol.   The external composition according to claim 1, wherein the content of the higher fatty acid is 5 to 25% by weight, the content of the higher fatty acid salt is 2 to 10% by weight, and the content of the higher alcohol is 0.5 to 8% by weight. .   The composition for external use according to claim 1 or 2, wherein the higher fatty acid and the higher fatty acid of the higher fatty acid salt are the same or different and are saturated or unsaturated fatty acids having 14 to 18 carbon atoms.   The external composition according to any one of claims 1 to 3, wherein the higher alcohol is a saturated or unsaturated monohydric alcohol having 14 to 18 carbon atoms.   The composition for external use in any one of Claims 1-4 whose saponification rate is 20 to 40%.   The manufacturing method of the composition for external use in any one of Claims 1-5 which has the process of mixing these using at least a higher fatty acid, an alkali, and a higher alcohol as a raw material.