JP2000212027A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin sufficiently exhibiting the characteristic drug action of cell activation agent and moisture-retaining agent and having excellent skin aging prevention effect, skin roughening prevention effect and moisture-retaining effect by making the preparation include and acerola extract, a cell activation agent and a moisture retaining agent. SOLUTION: The objective preparation contains (A) an acerola extract and (B) a cell activation agent (e.g. deoxyribonucleic acid, adenosine triphosphate, serum deproteinizing extract and placenta extract) and/or a moisture-retaining agent (e.g. hyaluronic acid, condroitinsulfuric acid, and dermatansulfuric acid). The extract of the component A is produced by extracting a fruit of acerola which is a fruit tree belonging to the genus Malpighia with a proper extraction solvent at low temperature, normal temperature or under heating. The preferable compounding amount of the above component is 0.00005-5 wt.% for the component A in terms of dried solid, and 0.00001-10 wt.% for the sell activation agent and 0.00001-70 wt.% for the moisture-retaining agent of the component B.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin containing an acerola extract and a specific medicinal ingredient, and more particularly, it has an excellent effect of preventing skin aging, improving skin roughness, and moisturizing effect. The present invention relates to a skin external preparation capable of giving a bite and gloss.

[0002]

2. Description of the Related Art Conventionally, an external preparation for skin such as milky lotion, cream, lotion, pack, dispersion, detergent, ointment, cream, liquid for external use, etc. is intended to impart a predetermined medicinal effect to them. Pharmaceutical ingredients such as cell activators and humectants are added. For example, to improve skin roughness, prevent skin aging, activate cells, treat wounds after cutting and shaving, and treat wounds such as cracks, irritations, sores, hemorrhoids, burns, etc. , A placenta extract, bovine blood deproteinization, and fermentation metabolites.

[0003]

However, in a skin external preparation containing a cell activator or a humectant, the effect of the cell activator or the humectant is not sufficient, or an amount sufficient to obtain the medicinal effect is not sufficient. When blended, there are problems such as lack of stability and impaired usability. An object of the present invention is to provide a skin external preparation that has solved such problems.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to improve the effects of the medicinal components of the cell activator and the humectant. As a result, the acerola extract and the cell activator and / or the humectant were used. It has been found that by combining the above, the action of the medicinal component originally possessed by the cell activator and the humectant is sufficiently exhibited, and the present invention has been completed. That is, the present invention
(A) an acerola extract, and (B) a cell activator and / or
Or a skin external preparation containing a moisturizer.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The acerola extract, which is the component (A) of the external preparation for skin of the present invention, comprises Malpighia.
Acerola (Acerola, scientific name Malpighia emar)
ginata DC; Acerola's scientific name differs in writing in papers and the like depending on the age, region, and researchers. Previously Malpig
hia punicifolia L. and Malpighia glabra L. are confused and used as acerola scientific names.
"TROPI" edited by Steven Nagy et al. In 1980
CAL AND SUBTROPICAL FRUITS "
hia emarginata DC is most suitable. ) The fruit is extracted using an extraction solvent. The extraction treatment is not particularly limited, but the extraction is carried out at a low temperature or at room temperature or with a suitable solvent.

Examples of the above-mentioned extraction solvent include one or more of water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; and liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol. Can be used. As an example of a preferable extraction method, after performing extraction at a low temperature using purified water, filtration is performed, and 1,3-butylene glycol is further mixed to a concentration of 20 to 70% (W / W). And a method of performing filtration again.

The amount (content) of the acerola extract in the external preparation for skin of the present invention is preferably 0.00005 to 5% by weight as dry solid content (hereinafter, "% by weight" is simply indicated by "%"). And more preferably 0.0005 to 1%. The content of this acerola extract is 0.00
If the amount is less than 005%, a sufficient effect may not be obtained, and if the amount exceeds 5%, no further increase in the effect is observed.

The component (B) of the external preparation for skin of the present invention is selected from a cell activator and / or a humectant. Specifically, the following are shown, respectively. As a cell activator, deoxyribonucleic acid and salts thereof, adenosine triphosphate, adenylic acid derivatives such as adenosine monophosphate and salts thereof, ribonucleic acid and salts thereof,
Cyclic AMP, cyclic GMP, flavin adenine nucleotide, guanine, adenine, cytosine,
Thymine, xanthine and their derivatives caffeine, theophylline and nucleic acid related substances such as their salts,
Placenta extracts of pigs, cows, etc., calf blood extracts, serum deproteinized extracts, spleen extracts, egg components such as birds, cockscomb extracts,
Mammals and birds such as shellfish extract, shellfish extract, royal jelly, silk protein and its degradation products or their derivatives, hemoglobin or its degradation products, lactoferrin or its degradation products, mollusk extracts such as squid, fish meat extracts, etc. And extracts derived from microorganisms selected from fermentation metabolites such as extracts from animals such as shellfish, insects, fish, and crustaceans, yeast extracts, lactic acid bacteria extracts, and bifidobacteria extracts.

As cell activators, vitamin A such as retinol and its derivatives (retinol palmitate, retinol acetate, etc.), retinal and its derivatives, carotenoids such as dehydroretinal and carotene, and thiamines (thiamine hydrochloride, thiamine sulfate) Salts), riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), flavin adenine nucleotides, cyanocobalamin, folic acids, nicotinic acids (nicotinamide, benzyl nicotinate, etc.), Vitamin B such as choline
C, vitamin Cs such as ascorbic acid and its derivatives,
Asparagus extract, apricot extract, ginkgo extract,
Panax ginseng extract, barley extract, oak extract, orange extract, cucumber extract, kiwi extract,
Shiitake extract, horsetail extract, Japanese cabbage extract, Japanese radish extract, Calendula extract, Pepper extract, Garlic extract, Carrot extract, Bulberry extract, Beech bud extract, Peach extract, Lettuce extract , Lemon extract, eucalyptus extract, ganoderma extract, rosemary extract, hinokitiol, cepharanthin, grape seed oil and other plant-derived extracts, α- and γ-linolenic acid, eicosapentaenoic acid and derivatives thereof, Estradiol and its derivatives and their salts, glycolic acid,
Organic acids such as succinic acid, lactic acid, and salicylic acid, and derivatives thereof, and salts thereof, and the like. One or more of the above-mentioned cell activators can be appropriately selected and blended.

The above-mentioned vitamin Cs such as ascorbic acid and its derivatives include L-ascorbic acid, L-ascorbyl palmitate, L-ascorbyl dipalmitate, L-ascorbyl isopalmitate, and L-ascorbyl diisopalmitate. , Tetraisopalmitic acid L-
Ascorbyl, L-ascorbyl stearate, L-ascorbyl distearate, L-ascorbyl isostearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl dimyristate, L-ascorbyl isomyristate, diisomyristate L-ascorbyl, L-ascorbyl oleate, L-ascorbyl dioleate, L-ascorbyl 2-ethylhexanoate, sodium L-ascorbate, potassium L-ascorbate, potassium L-ascorbate Magnesium, calcium L-ascorbate, aluminum phosphate L-ascorbate,
Sodium L-ascorbate, potassium L-ascorbate, magnesium L-ascorbate, calcium L-ascorbate, aluminum L-ascorbate, aluminum L-ascorbate, L-ascorbate Potassium, magnesium L-ascorbate, calcium L-ascorbate, aluminum L-ascorbate and the like.

Of these cell activators, particularly preferred are deoxyribonucleic acid and its salts, adenosine triphosphate and its salts, serum deproteinized extract, placenta extract,
Examples include yeast extract, Panax ginseng extract, rosemary extract, capsicum extract, ginkgo extract, barley extract, royal jelly extract, lactic acid, succinic acid and derivatives thereof, and salts thereof.

Examples of the humectant include alkaline simple hot spring water, deep water, mucopolysaccharides such as hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate or salts thereof, and proteins such as collagen, elastin and keratin. Or their derivatives and their salts, soybean and egg-derived phospholipids, glycolipids,
Ceramide, mucin, honey, erythritol, maltose, maltitol, xylitol, xylose, pentaerythritol, fructose, dextrin and derivatives thereof, mannitol, sorbitol, inositol, trehalose, sugars such as glucose, urea, asparagine, aspartic acid, alanine, arginine , Isoleucine, ortinine, glutamine, glycine, glutamic acid and derivatives thereof and salts thereof, cysteine, cystine, citrulline, threonine, serine, tyrosine,
Examples include tryptophan, theanine, valine, histidine, hydroxylysine, hydroxyproline, pyrrolidonecarboxylic acid and salts thereof, amino acids such as proline, phenylalanine, methionine, and lysine, and derivatives or salts thereof.

Further, as humectants, D-panthenol, avocado extract, altea extract, arnica extract, ashitaba extract, aloe extract, almond oil, carob extract, rice extract, strawberry extract, fennel extract Thing, turmeric extract, Usniaia oil extract, saishin extract, perilla oil, spinach extract, olive oil, hydrangea extract, hypericum extract, gongon extract,
Ononis extract, Kombu, Macomb, Wakame, Hijiki,
Hibamata, Sea turtle, Matsumo, Mozuku, Ishige, Habanori, Kombumodoki, Fukuronori, Iwahige, Kagomenori, Aname, Sujime, Trolocomb, Kajime, Tsuruarame, Chigaiso, Ezoishige, Lappamok, Hondawara,
Brown algae such as gibbertail, giant kelp, and the like; tengusa, nettle, lynx, oberxa, sasa nori, giraffe, tsunomata, tochiyaka, suginori, shikinori,
Kainori, Usubanori, Ushikenori, Asakusanori, Fusanori, Kaginori, Hibiriudo, Catanori, Mukadenori, Matsunori, Tosakamatsu, Funori, Ibaranori, Ogonori, Caimensou, Dars, Igisu, Egonori, Konohanori, Hydrangea, Hydrangea, etc .; Examples include seaweed extracts such as green algae such as chlorococcus, anaoasa, kawanori, marimo, shiogusa, kasanori, phtojuzmo, tamajuzumo, human enthusiast, and amidro.

Further, as humectants, cacao butter, cinnamon extract, chamomile extract, oat extract, licorice extract, kizuta extract, raspberry extract, goldfish, kumazasa extract, gardenia extract, grapefruit extract , Kudin extract, watercress extract, ginger extract, gentian extract, burdock extract, kobotdur extract, wheat extract, sesame extract, comfrey extract, cactus extract, saponosa extract, hawthorn extract, Salvia extract, Ginger extract, Perilla extract, Zio extract, Shea butter, Spiraea extract, Peony extract, Birch extract, Senkyu extract, Zeniai extract, Soybean extract, Scotch extract, Soy extract Products, green tea, black tea, tea extract such as oolong tea,
Camellia extract, corn extract, Eucommia magnolia extract, Tormentilla extract, eucommia extract, Dokudami extract, Bakumondou extract, Hawthorn extract, Hamamelis extract, Mint extract, Green pepper extract, Parsley extract, Parsley Extract, rose extract, sunflower extract, hinoki extract, loofah extract, grape extract, prune extract, butchers bloom extract, borage oil, button extract, jojoba oil, bodaige extract, hop extract, Pine extract, horse chestnut extract, macadamia nut oil, quince extract, murasaki extract, meadow home oil, melissa extract, mukuroji extract, cornflower extract, lily extract, yuzu extract, yukinoshita extract, yoquinin extract , Arhat extract, lime extract, lavender extract , Gentian extract, burnet extract, apple extract and Rengesou extract, and the like. One or two or more of the above-mentioned humectants can be appropriately selected and blended.

Of these humectants, particularly preferred are constituents of the skin, such as hyaluronic acid, chondroitin sulphate, dermatanic acid, heparan sulphate, heparin and keratan sulphate which are conventionally incorporated in cosmetics. Mucopolysaccharides and their salts, proteins such as collagen, elastin, and keratin and their derivatives, and their salts, Altea extract, Arnica extract, Ashitaba extract, Aloe extract, Gourd extract, and Quince extract. . Each of these components is not particularly limited with respect to its origin, and may be any of animal origin, plant origin, microorganism origin, and synthetic products. Further, there is no particular limitation on the production method such as the extraction method and the purification treatment method.

The content (content) of the cell activator in the composition of the present invention is preferably 0.00001 to 10%, more preferably 0.0001 to 5%, and the content (content) of the humectant. Is preferably 0.00001 to 70%,
More preferably, it is 0.0001 to 20%. When a plant extract or the like is used as it is as an extract, it is converted as a dry solid content. If the amount of the cell activator and / or humectant is within this range, when combined with the acerola extract, it does not affect the acerola extract in the external preparation for skin,
In addition, the acerola extract acts on the cell activator and / or humectant, and the external preparation for skin has good stability over time, exhibits excellent cell activating effects and moisturizing effects, and has an excellent feeling in use.

The skin external preparation of the present invention is prepared by blending the essential components (A) and (B) with various types of bases known as ordinary skin external preparations according to a conventional method. Can be. The form of the skin external preparation is not particularly limited, and examples thereof include, for example, emulsions, creams, lotions, packs, skin care cosmetics such as cleaning agents, lipsticks, makeup cosmetics such as foundations, scalp cosmetics, and ointments. Dispersion,
Creams, pharmaceuticals such as liquids for external use, etc., can be used in any form, and there is no particular limitation on the form of the preparation. Solid, paste, mousse, gel, powder, solution, solubilization,
It can be emulsified, powder dispersed, or multilayer.

In addition to the components (A) and (B), the external preparation for skin of the present invention usually contains cosmetics, quasi-drugs, and external medicines as long as the effects of the present invention are not impaired. Ingredients used in the formulation, i.e., water, oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, UV protection agents, clathrate compounds, antibacterial Agents, fragrances, deodorants, salts, pH regulators, cooling agents, animal / microbial extracts, plant extracts, blood circulation enhancers, astringents, antiseborrheic agents, active oxygen scavengers, whitening agents, anti-inflammatory One, two or more agents, keratolytic agents, enzymes, hormones, vitamins, and the like can be appropriately added.

[0019]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of acerola extract Acerola (Acerola, scientific name Malpighia emarginata DC)
Purified water was added to the fruit of No. 1 and the mixture was extracted at low temperature for one day and filtered to obtain an acerola extract (dry solid content 1.7).
%).

Reference Example 2 Production of placental extract 1 kg of placenta of 3-4 month pregnant cows was frozen, thawed, and impurities were washed and removed, 5 liters of purified water was added, extracted under reduced pressure and low temperature for 3 days, and filtered to extract placenta extract. (3.5% dry solids).

Reference Example 3 Production of Panax ginseng extract 250 g of Panax ginseng root was finely chopped, and 1 liter of absolute ethanol was added thereto, and the mixture was stirred and extracted all day and night using a blender to obtain a carrot extract (dry solid content: 1.1%).

Reference Example 4 Production of aloe extract 100 g of aloe leaves are minced and squeezed, and 100 ml of absolute ethanol is added to the obtained sap, extracted at room temperature with occasional stirring, and filtered to obtain an aloe extract (dry solids content). 1.0%).

Reference Example 5 Production of lactic acid bacteria extract 1% of a milk protein aqueous solution is inoculated with 1% of a lactic acid bacterium and cultured at 40 ° C. for 3 days. 80 of the obtained fermented milk
The solution was flash sterilized at ℃ and filtered to obtain a lactic acid bacteria extract (dry solid content: 9.5%).

Reference Example 6 Manufacture of seaweed extract 20 g of whole plant of brown algae was minced, 100 ml of 1,3-butylene glycol was added, extracted at room temperature for 3 days with occasional stirring, and filtered to obtain a seaweed extract (dry solids content). 1.2
%).

Reference Example 7 Production of Hawthorn Extract 10 g of Hawthorn seeds were cut into pieces, and anhydrous ethanol 10 g
0 ml was added, extraction was carried out at room temperature for 5 days with occasional stirring, and filtration was carried out to obtain a bean extract (dry solids 1.
9%).

Reference Example 8 Production of Assembly Extract 10 g of whole plant of the assembly is cut into pieces, and anhydrous ethanol 100
The mixture was extracted at room temperature for 3 days with occasional stirring, and filtered to obtain an assembly extract (dry solid content: 1.0%).

Test Example 1 Fibroblast Proliferation Test An appropriate amount of medium is taken in a petri dish, and human neonatal fibroblasts are inoculated and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. On the next day, the concentration of each of the freeze-dried cell activators shown in Table 1 was 100 μg / ml, and the acerola extract was 100 mg / m2.
The solution is dissolved in PBS (phosphate buffer solution) so as to obtain 1 l, and 1/10 of the medium is added to a Petri dish and mixed. As a control,
Add PBS. The cell number (A) and the control cell number (B) for each sample were measured, and the cell growth rate was calculated by the following equation. Table 1 shows the results. Cell growth rate (%) = (A / B) × 100 where A: number of cells when sample is added B: number of cells when sample is not added

[0029]

[Table 1]

As is clear from the results shown in Table 1, a very high cell growth promoting effect can be obtained by combining the acerola extract with the placenta extract and panax ginseng extract which are cell activators.

Example 1 Preparation Example of Cream A cream was prepared according to the composition shown in Table 2 and the following method, and its skin effect was examined. Table 2 also shows the results.

[0032]

[Table 2]

(Production method) A. Components (1) to (5) are mixed and heated to 70 ° C. B. Components (6), (9), (11), (13) and (14) are mixed and heated to 70 ° C. C. Add B to A, mix and cool. D. C, (7), (8), (10) and (12) were added to obtain a cream.

(Test Method) Using a panel of 15 healthy people aged 24 to 45 years old, the skin condition before causing experimental rough skin was photographed with a microscope camera, and the score was obtained according to the following criteria. Experimental rough skin was caused by treating the upper arm flexion side with a mixture of ether and acetone (1: 1). After that, the test emulsion was applied twice a day, in the morning and at night, for 7 days, and the scores of the skin condition were obtained in the same manner as described above 1, 3, 5 and 7 days after the rough skin was induced. The scores were averaged to evaluate the effect of improving and preventing skin roughness.

[Skin Condition Score] <Score><State> 1 Skin groove of skin is unclear and exfoliation of keratin is recognized. 2 Skin crevices are slightly unclear or strongly unidirectional. 3 Skin sulcus is recognized but shallow or strongly unidirectional. 4 Skin sulcus is recognized or slightly reticulated. 5 Skin crevices are clearly recognized or have a fine mesh. The results obtained by the above evaluation method are also shown in Table 2. As is clear from the results in Table 2, the cream containing the acerola extract and the humectant according to the present invention can prevent and improve the occurrence of rough skin by applying them to the skin, and can improve the beautiful skin. We were able to.

Example 2 Preparation Example of Emulsion An emulsion having the composition shown in Table 3 was prepared and its effect on preventing skin aging was examined. Table 3 also shows the results.

[0037]

[Table 3]

(Production method) A part of the component (14) and (6), (11) and (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (5) are mixed by heating and maintained at 70 ° C. C. Add the above B to the above A, mix and add the component (10) to emulsify uniformly, cool to 30 ° C., add the component (12) and mix uniformly. D. The components (7) to (9) are mixed with the residue of the component (14), added to C, and uniformly mixed to obtain an emulsion.

(Test method) 26 to 5 per test emulsion
A panel of 15 0-year-old women, twice daily, morning and night,
After washing the face for 12 weeks, an appropriate amount of the test emulsion was applied to the face. The antiaging effect of the skin by application was evaluated according to the following criteria.

Anti-aging effect of skin: [Evaluation] [Contents] Effective Skin peeling and gloss were improved. Slightly effective Skin glue, gloss slightly improved. Ineffective No change from before use. Table 3 also shows the results obtained by the above evaluation method.
As is clear from the results in Table 3, the emulsion containing the acerola extract and the cell activator according to the present invention is applied to the skin to improve the skin's adhesion and gloss, and to prevent skin aging. I was able to.

Example 3. Preparation Example of Lotion (Formulation) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) Sorbitan 1.2 Monolaurate ester (4) Ethyl alcohol 8.0 (5) Acerola extract * 1 1.0 (6) Quince extract * 2 1.0 (7) Barley extract * 3 1.0 (8) Preservatives Appropriate amount (9) Fragrance Appropriate amount (10) Alkaline simple hot spring water * 4 50.0 (11) Remaining purified water * 1 Manufactured in Reference Example 1 * 2 Koei Kogyo * 3 Technol * 4. Maruzen Pharmaceutical Co., Ltd. (Production method) Components (3), (4), (8) and (9) are mixed and dissolved. B. Components (1), (2), (5) to (7), (10) and (11) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Example 3 was a lotion having excellent stability over time, improving skin abrasion and gloss, and having an excellent moisturizing effect and an effect of improving rough skin.

Example 4. Preparation of Ointment (Formulation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5 ) Acerola extract * 1 0.01 (6) Ashitaba extract * 2 1.0 (7) Sodium hyaluronate * 3 1.0 (8) Remaining purified water * 1 Produced in Reference Example 1 * 2 Ichimaru Falcos * 3 Nikko Chemicals

(Production Method) A. A part of components (3), (4) and (8) are mixed by heating, and
Keep at ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. C was dissolved in the remainder of (8) while cooling (5) to (7)
Was added to obtain an ointment. Example 4 was an ointment that had an excellent moisturizing effect and was effective in improving skin roughness.

Embodiment 5 Preparation Example of Pack (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethanol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Acerola extract * 1 0.05 (6) Hazelnut extract * 2 3.0 (7) Preservatives appropriate amount (8) Flavors appropriate amount (9) Purified water balance * 1 Manufactured in Reference Example 1 * 2 Manufactured in Reference Example 7

(Production method) Mix components (1), (3), (4) and (9), heat to 70 ° C. and stir. B. Mix components (2), (7) and (8). C. Add the above B to the above A, mix and cool
(5) and (6) were uniformly dispersed to obtain a pack. Example 5 was a pack having an excellent moisturizing effect and giving moisture to the skin.

Embodiment 6 Preparation Example of Cleaning Agent (Formulation) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl alcohol 5 (6) Refined lanolin 1.0 (7) Perfume proper amount (8) Preservative proper amount (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) Acerola extract * 1 0.5 (12) D-panthenol * 2 0.05 (13) Purified water Remaining amount * 1 Manufactured in Reference Example 1 * 2 Sigma

(Production method) A. Mix components (9), (10) and (13) and heat to 70 ° C. B. Combine components (1)-(6), (8) and (12) and heat to 70 ° C. C. The above B was added to the above A, and kept at 70 ° C. for a while. After the reaction was completed, the mixture was cooled to 50 ° C., and the components (7) and (11) were added. Example 6 was a cleaning agent that imparts moisture to the skin after washing and prevents bulkiness of the skin.

Example 7 Production Example of Lipstick (Prescription) (%) (1) Acerola extract * 1 0.02 (2) γ-linolenic acid * 2 0.02 (3) Lactic acid bacterium extract * 30 001 (4) Red No. 202 0.2 (5) Candelilla wax 9.0 (6) Solid paraffin 8.0 (7) Beeswax 5.0 (8) Carnauba wax 5.0 (9) Lanolin 11.0 (10) ) Isopropyl myristate 10.0 (11) Refined castor oil Remaining (12) Preservative proper amount (13) Flavor proper amount * 1 Manufactured in Reference Example 1 * 2 Idemitsu Petrochemical Company * 2 Manufactured in Reference Example 5 thing

(Production method) After heating and dissolving the components (5) to (12), they are kneaded with three rollers. B. After adding components (1) to (3) and (13) to A,
Knead with this roller. C. B was cooled and molded to obtain a lipstick. Example 7 was a lipstick that prevented roughening of the lips and provided good gloss and abrasion.

[0051]

The external preparation for skin of the present invention is obtained by blending an acerola extract with a cell activator and / or a humectant.
The cell activating agent and the moisturizing agent can sufficiently exert their inherent medicinal effects. For example, a skin external preparation combined with a cell activator as a medicinal ingredient has a stable and excellent anti-aging effect on the skin, so that it maintains the skin's shine and luster and exhibits a high inhibitory effect on wrinkle formation, An external preparation for skin combined with a humectant exhibits a skin roughness improving effect and a moisturizing effect. As described above, the skin external preparation of the present invention can be used in cosmetics and medical treatment because it can improve the intrinsic efficacy of the cell activator and the moisturizer by being combined with the acerola extract.

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[Procedure amendment]

[Submission date] August 31, 1999 (1999.8.3)
1)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0037

[Correction method] Change

[Correction contents]

[0037]

[Table 3]

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61P 17/00 A61K 31/00 617 17/16 617J A61K 35/78 35/78 C (72) Inventor Yuki Hata Tokyo 48-18 Sakaemachi, Kita-ku Inside Kose Research Laboratory (72) Inventor Shizuka Uehara 48-18 Sakaemachi, Kita-ku, Tokyo Inside (72) Inventor Ichiro Sasaki 48 Sakaemachi Kita-ku, Tokyo No. 18 Kose Research Co., Ltd. (72) Kenichi Nagamine, Inventor 2-5-1-203, Misumi-cho, Higashimurayama-shi, Tokyo (72) Takashi Kito 1-21- 25-103 Namiki, Kawaguchi-shi, Saitama F term (reference) 4C083 AA031 AA032 AA071 AA082 AA111 AA112 AA121 AA122 AA161 AB032 AB442 AC012 AC022 AC072 AC102 AC122 AC131 AC182 AC242 AC251 AC291 AC301 AC352 AC442 AC471 AC542 AC581 AC611 AC621 AC641 AC792 AD851 AD312 AD321 AD312 AD591 AD592 AD601 AD621 AD631 AD641 BB51 CC02 CC05 CC07 CC13 DD 22 DD31 EE12 FF05 4C088 AA04 AA06 AA08 AA12 AA18 AB02 AB03 AB12 AB13 AB14 AB15 AB16 AB18 AB19 AB25 AB26 AB32 AB34 AB38 AB40 AB41 AB45 AB47 AB50 AB51 AB52 AB54 AB55 AB56 AB57 AB59 AB62 AB66 AB67 AB73 AB74 AB76 AB77 AB78 AB81 BA06 BA08 CA03 MA08 MA11 MA63 NA14 ZA89

Claims (5)

[Claims] An external preparation for skin, comprising the following components (A) and (B): (A) Acerola extract (B) Cell activator and / or humectant 2. A cell activator comprising deoxyribonucleic acid and salts thereof, adenylic acid derivatives and salts thereof, ribonucleic acids and salts thereof, cyclic AMP, cyclic GMP, flavin adenine nucleotide, guanine, adenine, cytosine, thymine, Nucleic acid related substances selected from xanthine and their derivatives caffeine, theopherin and their salts; placenta extract, calf blood extract, serum deproteinized extract, spleen extract, egg component, cockscomb extract, shell An extract derived from an animal selected from an extract, a shell meat extract, royal jelly, silk protein and its degradation product or a derivative thereof, hemoglobin or its degradation product, lactoferrin or its degradation product, mollusc extract, and fish meat extract; Microbial extract selected from fermentation metabolites; Vitamin A
And their derivatives, their salts, vitamins B and their derivatives, and their salts, vitamin C and its derivatives, and vitamins selected from their salts;
Asparagus extract, apricot extract, ginkgo extract,
Panax ginseng extract, barley extract, oak extract, orange extract, cucumber extract, kiwi extract,
Shiitake extract, horsetail extract, Japanese cabbage extract, Japanese radish extract, Calendula extract, Pepper extract, Garlic extract, Carrot extract, Bulberry extract, Beech bud extract, Peach extract, Lettuce extract , A lemon extract, a eucalyptus extract, a Reishi extract, a rosemary extract, a hinokitiol, a cepharanthin, a plant extract selected from grape seed oil; α- and γ-linolenic acid,
The organic acid selected from eicosapentaenoic acid and derivatives thereof, estradiol and derivatives thereof, and salts thereof, glycolic acid, succinic acid, lactic acid, and salicylic acid, and derivatives thereof and salts thereof. External preparation for skin. 3. The moisturizer is alkaline simple hot spring water, deep water, mucopolysaccharide or a salt thereof, protein or a derivative thereof, a salt thereof, a soybean or egg-derived phospholipid,
Glycolipid, ceramide, mucin, honey, erythritol, maltose, maltitol, xylitol, xylose, pentaerythritol, fructose, dextrin and its derivatives, saccharides, urea, asparagine, aspartic acid, alanine, arginine, isoleucine, ortinine, glutamine , Glycine, glutamic acid and its derivatives and their salts, cysteine, cystine, citrulline, threonine, serine, tyrosine,
Tryptophan, theanine, valine, histidine, hydroxylysine, hydroxyproline, pyrrolidonecarboxylic acid and its salts, proline, phenylalanine, methionine, amino acids selected from lysine and their derivatives and salts thereof, D-panthenol, avocado extract, artea Extract, Arnica extract, Ashitaba extract, Aloe extract, Almond oil, Carob extract, Rice extract, Strawberry extract, Fennel extract, Turmeric extract,
Usvenia mallow extract, saishin extract, perilla oil, spinach extract, olive oil, lycopodium extract, hypericum extract, syrup extract, ononis extract, seaweed extract, cocoa butter, intinko extract, chamomile extract, oat extract , Liquorice extract, Kizuta extract, Rubus extract, Kingfisher extract, Kumazasa extract, Gardenia extract, Grapefruit extract, Kujin extract, Watercress extract, Gennoshoko extract, Gentian extract, Burdock extract, Kobotdur extract, wheat extract, sesame extract, comfrey extract, cactus extract, saponosa extract, hawthorn extract, salvia extract, ginger extract, perilla extract, sage extract,
Shea butter, Spiraea extract, Peony extract, Birch extract, Senkyu extract, Zeniaoi extract, Soybean extract, Scotch extract, Soybean extract, Tea extract, Camellia extract, Maize extract, Eucalyptus extract Stuff, Tormentilla extract, Touki extract,
Dokudami extract, Bakkumondou extract, Hawthorn extract, Hamamelis extract, Mentha extract, Green peppermint extract, Common peppermint extract, Parsley extract, Rose extract, Sunflower extract, Hinoki extract, Loofah extract, Grapes Extract, prune extract, butchers bloom extract, borage oil, button extract, jojoba oil, bodaige extract, hop extract, pine extract, malonie extract, macadamia nut oil, quince extract, purple extract, meadow Home oil, melissa extract, sapling extract, cornflower extract, lily extract, yuzu extract, saxifrage extract, yokuinin extract, arhat extract, lime extract, lavender extract, gentian extract, waremokou extract Selected from apple extract and Astragalus extract Skin external preparation of Motomeko 1, wherein the. 4. The method according to claim 1, wherein the amount of the acerola extract is 0.00005 to 5% by weight as dry solids, and the amount of the cell activator is 0.00001 to 10% by weight. 2. The external preparation for skin according to item 1. 5. The method according to claim 1, wherein the content of the acerola extract is 0.00005 to 5% by weight as dry solids, and the content of the humectant is 0.00001 to 70% by weight. The topical skin preparation according to the above.