JP2001031558A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin lotion capable of enhancing the effects of usual bleaching agents and having stable and excellent bleaching actions. SOLUTION: This skin lotion is specific in containing one or more of the following ingredients (A) and (B); (A) an extract of Myrciaria Dubia and (B) a bleaching agent. The extract of Myrciaria Dubia of the ingredient (A) in this invention is prepared by extracting fruits of Myrcaria Dubia, a plant belonging to the family Myrtaceae by using an extracting solvent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin containing a camcam extract and a whitening agent, and more particularly, to a skin external preparation containing the same.
The present invention relates to an external preparation for skin having an excellent skin-whitening effect such as preventing the occurrence of pigmentation by the combination of a camcam extract and a whitening agent.

[0002]

2. Description of the Related Art Conventionally, medicinal components have been used in skin external preparations such as emulsions, creams, lotions, packs, detergents, dispersions, ointments, and external preparations for the purpose of imparting a predetermined medicinal effect to them. Have been added. For example, whitening agents such as ascorbic acid, glutathione, and hydroquinone have been added to prevent phenomena such as darkening of the skin caused by sunburn, pigmentation, and spots and freckles caused by pigmentation.

[0003]

However, skin external preparations containing these whitening agents, such as cosmetics and external medicines, are not effective enough for the whitening agent or may be deteriorated in the preparation. In some cases, the medicinal effect of the first stage may not be obtained, and improvement has been desired.

[0004]

Means for Solving the Problems The present inventors have made intensive studies to improve the effect of the medicinal component of the external preparation for skin. As a result, the combination of the camcam extract and the whitening agent originally possessed the whitening agent. The present inventors have found that the action is sufficiently exerted and completed the present invention.

That is, the present invention provides a skin external preparation characterized by containing the following components (A) and (B): (A) a camcam extract; and (B) a whitening agent.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The cam cam extract, which is the component (A) of the present invention, is a plant belonging to the family Myrtaceae, and is extracted from the fruit of cam cam (Myrcilia Dubia) using an extraction solvent. The preparation method is not particularly limited, but, for example, extraction is performed at low temperature or at room temperature to heating using various suitable solvents.

As the extraction solvent, for example, one or more of water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; and liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol are used. be able to. As an example of a preferred extraction method, extraction is performed at a low temperature for 2 to 3 days using ethyl alcohol having a water content of 20 to 90 vol%, followed by filtration, and the obtained filtrate is left to mature for about 5 days, There is a method of performing filtration again.

The content of the cam cam extract, which is the component (A) of the present invention, is preferably 0.0001 as a dry solid content.
To 5% by mass (hereinafter simply referred to as "%"), and more preferably 0.001 to 3%. When the content of the camu cam extract is in this range, the effects of the present invention are better exhibited.

As the whitening agent which is the component (B) of the present invention, the following are preferred. here,
“Derivatives” include salts that can be formed.

Preferred as whitening agents are endothelin antagonists, glutathione and its derivatives, N, N '
-Cysteine such as diacetylcystine dimethyl and its derivatives, resorcinol and its derivatives, hydroquinone and its derivatives, astaxanthin, lutein and other carotenoids, glabridine, glabrene, liquiritin,
Isoliquiritin, agarose oligosaccharides, neoagarobiose, sesame oil and sesame oil, and the like,
One or two or more of these can be appropriately selected and used.

Among these whitening agents, particularly preferred are glutathione, astaxanthin, glabridine and perilla oil. Each of these components is not particularly limited with respect to its origin, and may be any of animal origin, plant origin, microorganism origin, and synthetic products. The extraction method, purification method, production method, and the like are not particularly limited.

Other preferred whitening agents include licorice extract, chamomile extract, animal and plant extracts containing carotenoids such as egg yolk, krill, prawns and carrots, asparagus extract, pea extract, Agetsu extract, Japanese gourd extract, Ononis extract, Kombu, Macomb, Wakame, Hijiki, Hibamata, Umiuchiwa, Matsumo, Mozuku, Ishige, Habanori, Kombumodoki, Fukuronori, Iwahige, Kagomenori, Aname,
Brown algae such as sujime, trollocum, swordfish, swordfish, dabilia antarutica, tycaiso, esoysige, lappamoku, hondawara, oobamoku, and giant kelp, as well as tengusa, nettle, onyxa, oxaxa,
Tosakanori, Tsunomata, Tochiyaka, Suginori, Shikinori, Kainori, Usubanori, Ushikenori, Asakusanori, Fusanori, Kaginori, Hibiroudo, Catanori, Mukadenori, Matsunori, Tosakamatsu, Funori, Ibaranori,
Ogonori, sponge, Daruss, Igis, Egonori,
Seaweed extracts such as red algae such as Konohanori and Himegotake, and green algae extracts such as Chlorella, Aonori, Donariella, Chlorococcus, Aoosaa, Kawanori, Marimo, Shiogusa, Casanori, Fusuzumo, Tamazuzumo, Hitoegusa, Aomidoro, and Rubus Extracts, citrus extract, scabion extract, coffee extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, sampens extract, shirayuri extract, peonies extract, Sempukuka extract, soy extract Things, green tea, black tea,
Tea extracts such as oolong tea, molasses extract, tomato extract, juniper extract, beech bud extract, grape extract, flow de manita extract, hop extract, squid extract,
Examples include a mocca extract, a saxifrage extract, a eucalyptus extract, a yokuinin extract, and an arhat extract, and one or more of these can be appropriately selected and used.

Among these whitening agents, particularly preferred are licorice extract, oedum extract, yokuinin extract, kujin extract, seaweed extract, calyx extract, gokahi extract, sempens extract and sempukuka extract. , Tea extract, molasses extract, liquorice extract, grape extract, silkworm extract, mocca extract. These extracts are extracted, purified,
There is no particular restriction on the manufacturing method and the like.

The content of the whitening agent as the component (B) of the present invention is preferably 0.0001 to 5%, more preferably 0.001 to 3%. When the extract is used as it is as the extract, it may be in this range as a dry solid content. When the whitening agent as the component (B) of the present invention falls within the above range, when it is combined with the camcam extract as the component (A) of the present invention, it does not affect the preparation and the camcam extract in the preparation. Also, the stability with time is good, and a high whitening effect can be exhibited. These can be used alone or in combination of two or more.

The external preparation for skin of the present invention can be prepared according to a conventional method, using essential components (A) and (B) in various forms known as ordinary external compositions.

Examples of the form of the external preparation for skin are not particularly limited, and include, for example, skin care cosmetics such as milky lotions, creams, lotions, packs, cleaning agents, makeup cosmetics such as lipsticks, foundations, ointments and dispersions. , Can be pharmaceuticals such as liquids for external use, etc., and there is no particular limitation on the dosage form, solid form, paste form, mousse form, gel form,
It can be in the form of a powder, a solution, a solubilizing system, an emulsifying system, a powder dispersing system, or a multilayer.

In addition to the components (A) and (B), the external preparation for skin of the present invention usually contains cosmetics, quasi-drugs, and the like, as far as the effects of the present invention are not impaired, if necessary. Ingredients used in the preparation of external medicines, such as water (purified water, hot spring water, deep water, etc.), oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers,
Film forming agent, resin, ultraviolet ray protective agent, clathrate compound, antibacterial agent, fragrance, deodorant, salt, PH adjuster, freshener, animal
Microbial extracts, plant extracts, blood circulation enhancers, astringents,
Antiseborrheic agents, active oxygen scavengers, cell activators, humectants, keratolytic agents, enzymes, hormones, vitamins and the like can be added. Specific examples of suitable components include those shown below. Here, the “derivative” includes a salt that can be formed.

The oil may be a natural oil or a synthetic oil, as long as it is used in ordinary cosmetics, in order to improve the constituent components of the base or the usability and usability. Alternatively, irrespective of properties such as solid, semi-solid, and liquid, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine-based oils, and the like can be used. . For example, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, hydrocarbons such as petrolatum, beeswax, carnauba wax, candelilla wax, wax such as whale wax, tallow, cow Leg fat, beef bone fat, hardened tallow, hardened oil, turtle oil, animal oils such as lard, horse fat, mink oil, liver oil, egg yolk oil, lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, Lanolin fatty acid isopropyl, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, lanolin derivatives such as POE hydrogenated lanolin alcohol ether, lauric acid,
Myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, arachidonic acid, docosahexaenoic acid (DHA), eicosapentaenoic acid (E
PA) Fatty acids such as isostearic acid and 12-hydroxystearic acid, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol, seto Higher alcohols such as stearyl alcohol and 2-decyltetradecinol, diisobutyl adipate, and adipic acid-2-
Hexyldecyl, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isosetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate Trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate,
Di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearylate, dipentaerythritol Fatty acid esters, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, N-lauroyl-L-octyldodecyl glutamate Ester, ester oil such as diisostearyl malate, acetoglyceride, triisooctanoic acid glyceride, triisostearic acid glyceride, triisopalmitic acid Riseraido, tri-2-ethylhexanoic acid glyceride monostearate glyceride,
Glyceride oils such as di-2-heptylundecanoic acid glyceride and trimyristate glyceride, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane,
Silicone oils such as dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, and stearoxysilicone, and silicone oils such as silicone resin, silicone rubber, perfluoropolyether, perfluorodecane, and perfluorooctane, etc. .

Surfactants are used for emulsification and solubilization of oils and the like, and anionic, cationic, nonionic and amphoteric surfactants can be used.

The metal soap is a metal salt other than an alkali salt such as a fatty acid, and includes aluminum 12-hydroxystearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, cetyl phosphorus. Zinc acid, calcium cetyl phosphate, sodium sodium cetyl phosphate, zinc laurate, zinc undecylenate, and the like.

The gelling agent is used for stabilizing the system, improving the usability, and the feeling upon use. Amino acid derivatives such as N-lauroyl-L-glutamic acid and α, γ-di-n-butylamine, and dextrin palmitin Acid esters, dextrin stearate, dextrin fatty acid esters such as dextrin 2-ethylhexanoate palmitate, sucrose palmitate, sucrose fatty acid esters such as sucrose stearate, monobenzylidene sorbitol, dibenzylidene sorbitol, etc. Organically modified clay minerals such as benzylidene derivatives of sorbitol, dimethylbenzyldodecylammonium montmorillonite clay, and dimethyldioctadecylammonium montmorillonite clay.

The powder is used for various purposes such as coloring in makeup cosmetics, concealing skin, or improving the feeling of use. If it is used in ordinary cosmetics, the shape (spherical, needle, etc.) is used. Shape, plate shape, etc.), particle size (fog, fine particles, pigment grade, etc.), and particle structure (porous, non-porous, etc.), any of which can be used.
For example, as inorganic powders, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica, kaolin, sericite, muscovite, synthetic mica, phlogopite, mica, Biotite, lithium mica, silicic acid, silicic anhydride, aluminum silicate, magnesium silicate, aluminum magnesium silicate, sulfur-containing aluminum silicate,
Calcium silicate, barium silicate, strontium silicate, metal tungstate, hydroxyapatite,
Heidilite, montmorillonite, zeolite, ceramic powder, dibasic calcium phosphate, alumina, aluminum hydroxide, boron nitride, and the like.Examples of the organic powder include polyamide powder, polyester powder, polyethylene powder, polypropylene powder,
Polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, silk powder, nylon powder, 1
2 nylon, 6 nylon, styrene / acrylic acid copolymer, divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenol resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, fine resin Crystal fiber powder, lauroyl lysine and the like, and as the colored pigment, iron oxide, iron hydroxide,
Inorganic red pigments of iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, inorganic yellow pigments such as loess, black iron oxide,
Inorganic black pigments such as carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide, and cobalt titanate; inorganic blue pigments such as dark blue and ultramarine blue; and tar pigments Laked pigments, laked natural pigments, and pearl pigments include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride,
Metal powder pigments, such as titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scale foil, titanium oxide-coated colored mica, and the like, aluminum powder, copper powder, stainless steel powder, and the like, and other natural substances such as tar dyes and carminic acid Dyes and the like. These powders may be compounded, or may be surface-treated with an oil agent, silicone, or a fluorine compound.

UV protection agents protect the skin from UV rays,
It is useful when used in combination with a whitening agent. 2-Ethylhexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamate, di-paramethoxycinnamate-mono-2
Cinnamic acid type ultraviolet absorbers such as glyceryl ethylhexanoate, octyl methoxycinnamate, methyl diisopropylcinnamate, 2-phenylbenzimidazole-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone, 2- Hydroxy-4-methoxybenzophenone-5
-Sulfuric acid, 2-hydroxy-4-methoxybenzophenone-5-sodium sulfate, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone Benzophenone-based ultraviolet absorbers such as 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-n-octoxybenzophenone, para-aminobenzoic acid, ethyl para-aminobenzoate,
Benzoic acid type ultraviolet absorbers such as butyl paraaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, glyceryl paraaminobenzoate, amyl paraaminobenzoate, 2-ethylhexyl salicylate, triethanolamine salicylate, homomenthyl salicylate, dipropylene salicylate Glycol, methyl salicylate, ethylene glycol salicylate, phenyl salicylate, amyl salicylate, benzyl salicylate, isopropyl benzyl salicylate, potassium salicylate, and other salicylic acid-based ultraviolet absorbers, 4-t-butyl-4'-methoxydibenzoylmethane, 4-isopropyldi Benzoylmethane,
4-methoxydibenzoylmethane, 4-t-butyl-
Dibenzoylmethane-based ultraviolet absorbers such as 4'-hydroxydibenzoylmethane, menthyl-O-aminobenzoate, 2-phenyl-benzimidazole-5-sulfate,
2-phenyl-5-methylbenzoxazole, 3- (4
-Methylbenzylidene) camphor, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-
Anthranilic acid UV absorbers such as ethyl-2-cyano-3,3′-diphenylacrylate, 2- (2′-hydroxy-5-methylphenyl) benzotriazole and menthyl anthranilate, and urocanic acid bases such as ethyl urocanate Examples include ultraviolet absorbers and ultraviolet scattering agents such as titanium oxide, zirconium oxide, cerium oxide, and zinc oxide.

The water-soluble polymer is used for stabilizing the system, improving the usability and feeling of use, and also for obtaining a moisturizing effect. Specific examples of the water-soluble polymer include gum arabic, tragacanth, galactan, guar gum, karaya gum, carrageenan, pectin, agar, trant gum, locust bean gum, plant-based polymers such as galactomannan, xanthan gum, dextran, succinoglucan, and the like. Microbial polymers, casein, albumin, animal polymers such as gelatin, starch, carboxymethyl starch, starch polymers such as methylhydroxypropyl starch, methylcellulose, ethylcellulose,
Alginate polymers such as methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, nitrocellulose, cellulose sulfate, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, cellulose alginate, sodium alginate and propylene glycol alginate Vinyl polymers such as polyvinyl methyl ether, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyoxyethylene polymer, polyoxyethylene polyoxypropylene copolymer polymer, sodium polyacrylate, polyethyl acrylate, poly Acrylic polymers such as acrylamide, polyethyleneimine, cationic polymers, bentona DOO, laponite, and inorganic water-soluble polymers such as hectorite. In addition, film-forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone are also included in these.

The cell activator is used for the purpose of improving rough skin and the like. Deoxyribonucleic acid and salts thereof, adenylic acid derivatives such as adenosine triphosphate, adenosine diphosphate and adenosine monophosphate, ribonucleic acid and salts thereof, Cyclic A
MP, cyclic GMP, flavin adenine nucleotide, guanine, adenine, cytosine, thymine, xanthine derivatives caffeine, theophylline and their salts, calf blood extract, serum deproteinized extract, spleen extract, birds, etc. Egg components, cockscomb extract, shell extract, shellfish extract, royal jelly, silk protein and its degradation products or their derivatives, hemoglobin or its degradation products, lactoferrin or its degradation products, mollusc extracts such as cuttlefish, fish meat Extracts, animal-derived extracts such as mammals, birds, shellfish, insects, fish, molluscs, crustaceans,
Chondroitin sulfate, dermatan sulfate, heparan sulfate,
Mucopolysaccharides such as heparin, keratan sulfate and hyaluronic acid or their salts, collagen, lactic acid bacteria extract, extract from microorganisms such as fermentation metabolites such as Bifidobacterium extract, apricot extract, ginkgo extract, panax ginseng extract Stuff, barley extract, orange extract, cucumber extract, kiwi extract, shiitake extract, horsetail extract,
Assembly extract, syrup extract, capsicum extract,
Garlic extract, carrot extract, liquorice extract,
Peach extract, lettuce extract, lemon extract, eucalyptus extract, lily bulb extract, rosemary extract, hinokitiol, cepharanthin, grape seed oil and other plant-derived extracts, α- and γ-linolenic acid and the like Derivatives of
Organic acids such as eicosapentaenoic acid and derivatives thereof, estradiol, ethenyl estradiol, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, succinic acid, and salicylic acid, and derivatives thereof.

Active oxygen scavengers are used for the purpose of suppressing the production of lipid peroxides and the like. Superoxide dismutase, mannitol, bilirubin, cholesterol, tryptophan, histidine, quercetin, quercitrin, catechin and derivatives thereof, rutin and derivatives thereof,
Taurine, thiotaurine, eggshell membrane extract, gallic acid and its derivatives, yeast extract, ganoderma extract, yasajitsu extract, gennoshoko extract, buttonpi extract, melissa extract, parsley extract, dicoppi extract, retinol and Derivatives (retinol palmitate, retinol acetate, etc.), retinal and its derivatives, vitamin A such as carotenoids such as dehydroretinal and carotene, thiamines (thiamine hydrochloride, thiamine sulfate), riboflavins (riboflavin; riboflavin acetate, etc.) ), Pyridoxine (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), flavin adenine nucleotide, cyanocobalamin, folic acid, nicotinic acid (nicotinamide,
Vitamin B such as benzyl nicotinate), choline;
Vitamin Cs such as ascorbic acid; Vitamin Ds such as ergocalciferol, cholecalciferol and dihydroxystannal; tocopherol and its derivatives (d
l-α (β, γ) -tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, linoleic acid-dl-α-tocopherol, dl-α-tocopherol succinate, etc.), ubiquinones, etc. Vitamin E; dibutylhydroxytoluene and butylhydroxyanisole;

Examples of the humectant include proteins such as elastin, fibronectin and keratin, derivatives thereof, hydrolysates and salts thereof, glycine, alanine, valine, isoleucine, serine, threonine, aspartic acid, glutamic acid, asparagine, glutamine, and the like. Amino acids such as lysine, histidine, hydroxylysine, arginine, cysteine, cystine, methionine, phenylalanine, tyrosine, proline, theanine, tryptophan, hydroxyproline, ortinine, citrulline, and derivatives thereof, sorbitol, erythritol, maltitol, xylitol, xylose, Trehalose, inositol, glucose, pentaerythritol, fructose, sucrose and its derivatives, dextrin and its derivatives, honey Sugars, D- panthenol and its derivatives, urea, phospholipids, glycolipids, ceramides,
Avocado extract, almond extract, locust bean extract, rice extract, strawberry extract, fennel extract, avenger oyster extract, spinach extract, olive oil, hydrangea extract, cacao butter, oat extract, kizuta extract, kumazasa Extracts, Gardenia Extracts, Grapefruit Extracts, Gentian Extracts, Burdock Extracts, Kobotdur Extracts, Cactus Extracts, Soapwort Extracts, Ginger Extracts, Shobu Extracts, Geo Extracts,
Shea butter, Spiraea extract, Stevia extract, Senkyu extract, Zeniaoi extract, Scutellaria extract,
Camellia extract, corn extract, Eucommia extract, Tormentilla extract, Dokudami extract, Bakmondou extract, Hachiwa bean extract, Hamamelis extract, Mint extract, Green pepper extract, Common mint extract, Rose extract, Sunflower Extract, hinoki extract, dandelion extract, coltsfoot extract, prune extract, Butchers bloom extract, safflower extract,
Borage oil, jojoba oil, bodaiju extract, pine extract, marronnier extract, macadamia nut oil, quince extract, murasaki extract, meadow home oil, cornflower extract, yuzu extract, lime extract, lavender extract, gentian Extract, apple extract and the like.

Examples of the blood circulation promoting agent include nonyl acid valenylamide, capsaicin, zingerone, canthari tincture,
Ictamol, α-borneol, inositol hexanicotinate, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, γ-oryzanol and the like.

Tanninic acid and the like as skin astringents, thiantrol and the like as antiseborrheic agents, lipase as enzymes and
Papain and the like.

[0030]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of cam cam extract Cam cam (Myrcia, a fruit tree belonging to the family Myrtaceae)
To 30 g of dried ia Dubia fruit, 100 mL of 80 vol% ethyl alcohol was added, extracted for 3 days at room temperature, and then filtered to obtain a cam cam extract (dry solid content: 3.0%). .

REFERENCE EXAMPLE 2 Production of Plant Extract Licorice (JP), Kujin (Clara) (JP), AGETS (JP), Peony (JP), Yokuinin (JP)
70 vol% ethyl alcohol 1 for each 10 g
Add 00 mL, extract at room temperature for 3 days with occasional stirring, and filter to obtain each plant extract (dry solids are 2.0%, 1.0%, 1.0%, 1.1%, respectively) , 0.8
%).

Test Example 1 Tyrosinase Activity Inhibition Test Using the following method, the tyrosinase activity inhibition rate of the camcam extract obtained in Reference Example 1 and the plant extract obtained in Reference Example 2 was examined singly or in combination thereof. .
That is, an enzyme solution [Sigma, 28,000;
0 units of tyrosinase (10 mg) dissolved in 20 mL of 0.1 mol / L phosphate buffer (pH 6.8)]
1 mL was added, and 0.1 mol / L phosphate buffer (pH 6.8) was further added to make 4.0 mL, which was incubated at 25 ° C. for 10 minutes.

Next, the substrate solution [L-DOPA (manufactured by Tokyo Chemical Industry Co., Ltd.) 19
8.0 mg of 0.1 mol / L phosphate buffer (pH 6.0)
8) Dissolved in 100 mL] and added 1.0 mL
It was allowed to react for 0 minutes. After the reaction, the absorbance at 475 nm (OD _S ) was measured. Similarly, the absorbance (OD _HE ) when the reaction was performed using the enzyme inactivated by heating, the absorbance (OD _B ) when the enzyme was added and the sample was not added, and the sample and the inactivated enzyme were added. Absorbance (OD _{S HE} )
Was measured, and the activity inhibition rate of tyrosinase activity was calculated from Formula 1 and the results are shown in Table 1.

[0035]

(Equation 1)

[0036] OD _S: sample and enzyme addition when the absorbance OD _B: absorbance OD _HE when the enzyme is added to the sample without additives: enzyme inactivation when the absorbance OD _SHE: When the sample and the inactivated enzyme was added Absorbance of

(Result)

[Table 1]

* 1 Manufactured in Reference Example 1 * 2 Manufactured in Reference Example 2

As is evident from Table 1, when the camcam extract and the whitening agent were combined, the tyrosinase activity inhibiting effect was higher than when the camcam extract or the whitening agent was used alone.

Test Example 2 Melanin Production Inhibition Test by Cell Culture The melanin production inhibitory effect of the camcam extract obtained in Reference Example 1 and the plant extract obtained in Reference Example 2 alone or in combination was measured by the following method. Was examined. For the cultured cells, a mouse-derived B16 melanoma cultured cell was used.
Inoculate melanoma cells, 37 ° C, carbon dioxide concentration 5%
Let stand inside. The next day, each sample was mixed with a sample preparation so that the final concentration was 0 (control), 1, 10, 100 μg / mL. On the fifth day of the culture, the medium was replaced, and the sample preparation solution was added again. On the next day, the medium was removed, and one petri dish was washed with a phosphate buffer and then collected. The degree of whitening of the cultured B16 melanoma cells was evaluated according to the following criteria.

(Judgment criteria) ++: extremely white with respect to the control. +: Clearly white with respect to the control. ±: slightly white with respect to the control. -: Same black as the control.

For the remaining one petri dish, the cells were fixed in formalin and then added to a 1% crystal violet solution for staining. The viable cell ratio for each sample concentration was measured with a monocerator (Olympus). Table 2 shows the above results.

(Result)

[Table 2]

* 1 Manufactured in Reference Example 1 * 2 Manufactured in Reference Example 2

As is evident from Table 2, when the cam cam extract and the whitening agent are combined, the whitening effect is higher than when the cam cam extract or the whitening agent is used alone,
Further, it was confirmed that the toxicity was low for B16 melanoma cultured cells.

Test Example 3 Pigmentation Inhibition Test The back of a colored guinea pig (15 animals in each group) was shaved and irradiated with ultraviolet light under anesthesia. UV irradiation is performed by FL2 manufactured by Toshiba Corporation.
Irradiate three 0S • BLB lamps and three FL20S • E30 lamps at the same time, and the amount of ultraviolet rays is 4.8 × 10 ⁶ erg /
cm ² . Twenty-four hours before, immediately after, and 12 hours after and 24 hours after the irradiation with ultraviolet rays, 0.2 g each of the composition shown in Table 3 and the sample prepared by the following method were applied to four places on the back of the guinea pig. However, before irradiation, the application site was thoroughly washed with warm water. Seven days after irradiation, the degree of pigmentation was observed and evaluated according to the following criteria. Table 3 shows the results.

(Composition and results)

[Table 3]

* 1 Manufactured in Reference Example 1 * 2 Maruzen Pharmaceutical Co., Ltd.

(Production method) Mix components (1) to (6) and (9) and heat to 7
Keep at 0 ° C. B. Part of (11) is heated and kept at 70 ° C. C. Add B to A, mix and cool (7)
(8) and (10) were added and mixed to obtain a cream.

(Evaluation Criteria for Pigmentation Inhibition Effect) <Evaluation> <Contents> Excellent No pigmentation is observed at all. Effective Very slight pigmentation is observed. Slightly effective pigmentation is observed, but the boundary with the non-irradiated part is unclear. Ineffective Pigmentation was observed, and the boundary with the non-irradiated part was clear.

As shown in the results in Table 3, the skin external preparation of the product 1 of the present invention, in which the camcam extract and the yoquinin extract were combined, effectively inhibited pigmentation due to ultraviolet rays by applying them to the skin. It became clear to do.

Example 1 Cream: A cream was prepared by the composition shown in Table 4 and by the following method, and the whitening effect when a camcam extract and a whitening agent were combined was examined. Table 4 shows the results.

(Composition and results)

[Table 4]

* 1 manufactured in Reference Example 1 * 2 manufactured by Tanabe Seiyaku

(Production method) A. Mix components (1) to (6) and (9) and heat to 7
Keep at 0 ° C. B. Heat a portion of component (11) and maintain at 70 ° C. C. B was added to A, (8) and (10) dissolved in the remainder of (7) and (11) were mixed, and then cooled to obtain a cream.

(Test Method) 27 per test cream
A panel consisting of 15 women aged 54 to 54
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The whitening effect of the coating was evaluated according to the following criteria.

(Evaluation Criteria) <Evaluation> <Contents> Effective Skin dullness became inconspicuous. Slightly effective Skin dullness became less noticeable. Ineffective No change from before use.

As shown in the results of Table 4, the skin external preparation of the product 2 of the present invention in which the camcam extract and glutathione were combined was applied to the skin to prevent the occurrence of "dullness" and the like on the skin. It was found that the skin could be improved and the skin became beautiful.

Embodiment 2 FIG. Lotion (Formulation) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) 1.2 Sorbitan monolaurate (4) Ethyl Alcohol 8.0 (5) Camu cam extract * 1 1.0 (6) Rosewood extract * 2 0.01 (7) Appropriate amount of preservative (8) Appropriate amount of fragrance (9) Remaining amount of purified water * 1 In Reference Example 1 Manufactured * 2 manufactured by Suntory Limited

(Production method) A. Components (3), (4), (7) and (8) are mixed and dissolved. B. Components (1), (2), (5), (6) and (9) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Embodiment 3 FIG. Emulsion (Formulation) (%) (1) Polyoxyethylene (10EO) 1.0 Sorbitan monostearate (2) Polyoxyethylene (60EO) 0.5 Sorbit tetraoleate (3) Glyceryl mono Stearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Camcam extract * 1 5.0 (8) Astaxanthin * 2 0.1 (9) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Purified water Remaining (14) Perfume appropriate amount * 1 Produced in Reference Example 1 * 2 Sigma

(Production method) A. Components (11) to (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (6), (8) and (9) are mixed by heating and maintained at 70 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, (7), (10) and (14) were added and mixed uniformly to obtain an emulsion.

Each of Examples 2 and 3 has excellent stability over time, and when applied to the skin, prevents "dullness" of the skin due to sunburn, spots and freckles, and makes the skin beautiful and transparent. Water and emulsion.

Embodiment 4 FIG. Ointment (Formulation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Camcam extract * 1 1.0 ( 6) Gokahi extract * 2 0.5 (7) Grape extract * 3 0.1 (8) Remaining purified water * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Kikkoman

(Production method) A part of components (3), (4) and (8) are mixed by heating and kept at 75 ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. C was dissolved in the remainder of (8) while cooling (5),
(6) and (7) were added to obtain an ointment.

Example 4 was an ointment which was excellent in stability over time and applied to the skin to prevent "dullness" of the skin, spots and freckles, and to give a transparent and beautiful skin.

Embodiment 5 FIG. Pack (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Camcam extract * 1 0.05 (6) ) Bombyx mori extract * 2 0.2 (7) Preservative 0.2 (8) Fragrance 0.1 (9) Remaining purified water * 1 Produced in Reference Example 1 * 2 Manufactured by Maruzen Pharmaceutical Co.

(Production Method) Mixing components (1), (3), (4) and (9),
Heat to 70 ° C. and stir. B. Mix components (2) and (7). C. The above B was added to the above A, mixed, cooled, and (5), (6) and (8) were uniformly dispersed to obtain a pack.

Example 5 was a pack which was excellent in stability over time and applied to the skin to prevent the skin from becoming dull and blemishes, and to make the skin transparent and beautiful.

Example 6 Liquid foundation: (Formulation) (%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxy Cinnamic acid 3.0-2-ethylhexyl (6) 4-tert-butyl-4'-methoxy 1.0 dibenzoylmethane (7) Glycerin 5.0 (8) Triethanolamine 1.0 (9) Carboxymethylcellulose 0.7 (10) Remaining amount of purified water (11) Mica 15.0 (12) Talc 6.0 (13) Color pigment 6.0 (14) Camcam extract * 1 0.01 (15) Yokuinin extract * 2 0.5 (16) Appropriate amount of fragrance * 1 manufactured in Reference Example 1 * 2 manufactured in Reference Example 2

(Production Method) Components (1) to (6) are mixed and dissolved. B. Add components (11) to (13) to A, mix uniformly, and keep at 70 ° C. C. Components (7) to (10) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. E. FIG. After cooling D, components (14) to (16) were added to obtain a liquid foundation.

Example 6 was a liquid foundation which was excellent in stability over time and applied to the skin to prevent darkening of the skin due to sunburn, spots and freckles.

According to the present invention, the inherent properties of a whitening agent can be sufficiently exhibited by containing a camcam extract and a whitening agent. That is, since it has a stable and excellent whitening effect, it exerts a high inhibitory effect on pigmentation due to sunburn, and is effective in preventing / improving skin blackening, spots and freckles due to sunburn. As described above, the composition of the present invention can sufficiently exhibit the inherent performance of a whitening agent, and is therefore extremely useful in beauty and medicine.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA082 AA111 AA112 AA121 AB032 AB432 AB442 AC022 AC072 AC102 AC122 AC212 AC242 AC342 AC422 AC442 AC471 AC491 AC542 AC581 AC841 AD092 AD112 AD212 AD272 AD411 AD512 AD621 AD622 CC02 CC04 CC05 CC07 CC12 DD22 EE01 EE12 EE16 FF01 FF05

Claims (6)

[Claims] 1. An external preparation for skin, comprising the following components (A) and (B): (A) a camcam extract; and (B) a whitening agent. 2. The whitening agent is an endothelin antagonist, glutathione and its derivatives, cysteine and its derivatives, resorcin and its derivatives, hydroquinone and its derivatives, carotenoids, glabridine, glabrene, liquiritin, isoliquiritin, agarose oligosaccharide, neoaga 2. The external preparation for skin according to claim 1, wherein the external preparation is selected from roviose, sesame oil and perilla oil. 3. The external preparation for skin according to claim 2, wherein the content of the whitening agent is 0.0001 to 5% by mass. 4. A whitening agent comprising a liquorice extract, a chamomile extract, an animal or plant extract containing carotenoids, an asparagus extract, a pea extract, an age extract, a goug extract, an ononis extract, a seaweed extract Stuff, raspberry extract, jinjin extract, calyx extract, gokahi extract, coffee extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, sampens extract, white lily extract, peony extract , Sempukuka extract, Soybean extract, Tea extract, Molasses extract, Tomato extract, Juniper extract, Beech bud extract, Grape extract, Frodemanita extract, Hop extract, Maikaika extract, Mokka The extract is selected from the group consisting of an extract, a saxifrage extract, a eucalyptus extract, a yokuinin extract and an arhat extract. The topical skin preparation according to the above. 5. A whitening agent having a dry solid content of 0.
The external preparation for skin according to claim 4, wherein the amount is 0001 to 5% by mass. 6. The skin external preparation according to any one of claims 1 to 5, wherein the content of the camcam extract is 0.0001 to 5% by mass as a dry solid content.