JPH10330217A - Skin whitening preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation having higher skin whitening effect than conventional preparations formulated with skin whitening agent alone, by including extracts from Micromelum minutum and/or Micromelum pubescens and medicinal agent(s). SOLUTION: This preparation for external use for skin is obtained by including (A) extracts obtained by subjecting the dried leaves/twigs and trunks/barks/ flowers/fruits/roots of Micromelum minutum and/or Micromelum pubescens to extraction with a solvent such as a lower monohydric alcohol like methyl or ethyl alcohol or liquid polyhydric alcohol like 1,3-butylene glycol and (B) at least one kind of medicinal agent selected from skin whitening agents such as vitamin C, active oxygen removers such as mannitol, antioxidants such as vitamin C, anti-inflammatory agents such as glycyrrhizic acid and ultraviolet blocking agents such as homomenthyl salicylate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for whitening skin, and more particularly, to Micromelm Minutum.
rommelum minutum and / or Micromelum pubesc
ens) and an external preparation for whitening skin, comprising an extract and a medicinal agent.

[0002]

2. Description of the Related Art Conventionally, an external preparation for skin whitening,
Cosmetic products such as milky lotions, creams, lotions, packs, and cleaning agents, and quasi-drugs, ointments, dispersions, creams, and topical drugs such as topical solutions include skin blackening, irritation, and pigmentation caused by sunburn. A whitening agent such as vitamin C, glutathione, colloidal sulfur, hydroquinone, cinamic aldehyde and the like is blended in order to prevent blemishes and freckles caused by deposition.

[0003]

However, in the case of skin whitening preparations such as cosmetics and external medicines containing these medicinal ingredients, the medicinal ingredients are not sufficiently effective or the whitening agents are altered in the preparation. In many cases, the desired medicinal effect cannot be obtained due to such reasons, and improvement thereof has been desired.

[0004]

DISCLOSURE OF THE INVENTION The present inventors have conducted intensive studies to improve the whitening effect of a skin whitening agent for external use, and as a result, have found that Micromelum
The present invention has been found to show that a combination of an extract of C. minutum and / or Micromelum pubescens with a medicinal agent can provide a higher whitening effect than a conventional skin whitening agent containing only a whitening agent. Was completed.

That is, the present invention relates to the following components (A) and (B): (A) Micromelum
(B) a whitening agent, an active oxygen remover, an antioxidant, an anti-inflammatory,
An object of the present invention is to provide a skin whitening external preparation containing one or two or more medicinal agents selected from ultraviolet inhibitors.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Micromelum minutum used in the present invention,
Micromelum pubesensu
bescens) is a plant found in Southeast Asia such as Thailand and India.
It is used for antitussive purposes. The extract used in the present invention is Micromelum Minutum.
um minutum) and / or micromelum pubescens from dried leaves / branches / stems / bark / flowers / fruits / roots:
Extract using an extraction solvent. The preparation method is not particularly limited, but, for example, extraction is performed at low temperature or at room temperature to heating using various suitable solvents.

As the extraction solvent, for example, one or more of water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; and liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol are used. be able to. As an example of a preferable extraction method, extraction was performed at room temperature for 1 to 5 days using 1,3-butylene glycol or ethyl alcohol having a water content of 20 to 80% (v / v), followed by filtration, and the resultant was obtained. There is a method in which the filtrate is left to mature for about one week and then filtered again.

The amount of the extract of micromelum minutum and / or micromelum pvesense in the external preparation for whitening skin of the present invention is preferably 0.00 as a dry solid content.
005 to 5% by weight (hereinafter simply referred to as "%"), and more preferably 0.002 to 2%. Within this range, the micromelm minutum and / or micromelm
It is possible to stably blend the extract of Pubescens and exhibit a high whitening effect. When an extract is used, the concentration of the extract is not limited at all, as long as the amount of the dry solid as a solute is within the above range.

On the other hand, the medicinal agent of the component (B) of the present invention is selected from a whitening agent, an active oxygen scavenger, an antioxidant, an anti-inflammatory agent and an ultraviolet ray inhibitor. Are as follows.

(Whitening agents) Examples of whitening agents include glabridine, glabrene, liquiritin, isoliquiritin and liquorice extract containing them, vitamin C and its derivatives and salts thereof, hydroquinone and its derivatives and salts thereof, cysteine and its derivatives Derivatives and their salts, glutathione, placenta extract, Sempukuka extract,
The extract includes the extract of P. serrata, the extract of Sempens, the extract of Sophora serrata, the extract of eucalypt, the extract of Ibukitorano, the extract of Clara, the extract of hawthorn, the extract of white lily, the extract of hops, the extract of wild rose and the extract of yoquinin.

Of the above whitening agents, particularly preferred are vitamin C and its derivatives and salts thereof, hydroquinone and its derivatives and salts thereof, cysteine and its derivatives (eg, N, N'-diacetylcystine dimethyl and the like), and Its salts, glabridine, glabrene,
Liquiritin, isoliquiritin, and liquorice extract and placenta extract containing them.

(Active oxygen scavenger and antioxidant) Examples of the active oxygen scavenger include carotenoids such as SOD, mannitol and beta-carotene, hydroquinone, bilirubin, cholesterol, tryptophan, histidine, quercetin, quercitrin, catechin, Examples thereof include a catechin derivative, a gallic acid, a gallic acid derivative, a plant extract containing flavonoids such as a gougon extract and a ginkgo extract in a component, a saxifrage extract, a gokahi extract, a yasatsutsu extract, and a dicopi extract.

Among the above active oxygen scavengers, particularly preferred ones include mannitol, beta-carotene, pentagon extract and ginkgo extract.

Examples of the antioxidant include vitamin A acetate and vitamin A such as vitamin A palmitate.
C and their derivatives, their salts, vitamins B and their derivatives and their salts, magnesium L-ascorbyl phosphate, disodium sulfate L-ascorbate, vitamin C dipalmitate, and other vitamin C and derivatives thereof; Examples thereof include salts, vitamin Ds and derivatives thereof, salts thereof, vitamin E and derivatives thereof such as vitamin E linoleate, salts thereof, glutathione and derivatives thereof, and salts thereof, dibutylhydroxytoluene and butylhydroxyanisole, and the like. Can be

Among the above antioxidants, particularly preferred are vitamin C and its derivatives and salts thereof.
Vitamin E and its derivatives and their salts, dibutylhydroxytoluene.

(Anti-inflammatory agents) Examples of anti-inflammatory agents include glycyrrhizic acid, glycyrrhetinic acid, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene and derivatives thereof, salts thereof, ε-aminocaproic acid, Examples include zinc oxide, diclofenac sodium, aloe extract, sicon extract, salvia extract, arnica extract, chamomile extract, birch extract, hypericum extract, eucalyptus extract, and mukuroji extract.

Among these anti-inflammatory agents, particularly preferred are glycyrrhizic acid, glycyrrhetinic acid, guaiazulene and their derivatives and salts thereof, ε-aminocaproic acid, aloe extract, sicon extract and chamomile extract. .

(Ultraviolet inhibitor) As the ultraviolet inhibitor,
Para-aminobenzoic acid (hereinafter abbreviated as "PABA"), P
ABA ethyl, PABA glyceryl, N, N-dimethyl PABA amyl, N, N-dimethyl PABA-2-ethylhexyl, salicylic acid-2-ethylhexyl, ethylene glycol salicylate, homomenthyl salicylate,
-2-ethylhexyl methoxycinnamate, ethoxyethyl 4-methoxycinnamate, potassium 4-methoxycinnamate, methyl 4-5-diisopropylcinnamate, mono-2-ethylhexanoic acid diparamethoxycinnamate Glyceryl, 2-hydroxy-4-methoxybenzophenone, 2
-Hydroxy-4-methoxybenzophenonesulfonic acid, sodium 2-hydroxy-4-methoxybenzophenonesulfonate, 2,2′-dihydroxy-4,4 ′
Dimethoxybenzophenone, sodium 2,2′-dihydroxy-4,4′-dimethoxybenzophenone-5-sulfonate, 2-4-dihydroxybenzophenone,
2,2 ', 4,4'-tetrahydroxybenzophenone, 2- (2-hydroxy-5-methylphenyl) -benzotriazole, urocanic acid, ethyl urocanate, 4-t-butyl-4'-methoxy-dibenzoyl Examples include methane, titanium oxide, zinc oxide, iron oxide and the like.

Of these UV inhibitors, particularly preferred are homomenthyl salicylate, 2-ethylhexyl 4-methoxycinnamate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone sulfonic acid, Sodium hydroxy-4-methoxybenzophenonesulfonate, 4-t-butyl-4′-methoxy-dibenzoylmethane, titanium oxide,
It is zinc oxide.

The amount of the above-mentioned component (B) in the skin whitening preparation for external use of the present invention varies depending on the type of the drug, but is preferably in the following range. Within this range, when combined with the extract of (A) component micromelum minutum and / or micromelum pvesense, the formulation and the time-lapse of the extract of component (A) micromelum minutum and / or micromelm probeme in the formulation A higher whitening effect can be exhibited without affecting the stability.

That is, the compounding amount of the whitening agent in the skin whitening agent for external use of the present invention is preferably 0.0001-10.
%, More preferably in the range of 0.001 to 5%. When a plant extract or the like is used as it is as an extract, there is no problem as long as the dry solid content is within this range. Within this range, a whitening skin external preparation exhibiting a more excellent whitening effect and having a good feeling in use can be obtained.

The amount of the active oxygen remover is preferably 0.00001 to 5%, more preferably 0.001 to 3%.
% Range. When a plant extract or the like is used as it is as an extract, there is no problem as long as the dry solid content is within this range. Within this range, a more excellent active oxygen-removing effect is observed, and a skin whitening external preparation exhibiting an excellent whitening effect can be obtained.

The compounding amount of the antioxidant is preferably 0.00
001 to 5%, more preferably 0.001 to 3%. When a plant extract or the like is used as it is as an extract, there is no problem as long as the dry solid content is within this range. Within this range, a more excellent antioxidant effect can be obtained, and a skin whitening external preparation exhibiting an excellent whitening effect can be obtained.

The compounding amount of the anti-inflammatory agent is 0.0
The range is preferably 001 to 5%, more preferably 0.0
It is in the range of 1-3%. When a plant extract or the like is used as it is as an extract, there is no problem as long as the dry solid content is within this range. Within this range, a skin whitening external preparation exhibiting an excellent anti-inflammatory effect and exhibiting an excellent whitening effect can be obtained.

Further, the compounding amount of the ultraviolet inhibitor is preferably in the range of 0.0001 to 20%, more preferably 0.001 to 10%. When a plant extract or the like is used as it is as an extract, there is no problem as long as the dry solid content is within this range. Within this range, a skin whitening agent for external use exhibiting a more excellent ultraviolet ray preventing effect and exhibiting an excellent whitening effect can be obtained.

These whitening agents, active oxygen scavengers, antioxidants, anti-inflammatory agents and UV inhibitors can be used alone or in combination of two or more.

The skin whitening preparation of the present invention comprises essential components (A) and (B) in various forms known as conventional skin whitening preparations according to a conventional method. Can be prepared.

Examples of the form of the skin whitening external preparation are not particularly limited, and examples thereof include cosmetics such as lotions, emulsions, creams, packs, detergents, lipsticks, foundations, and the like, ointments, dispersions, and creams. , Quasi-drugs such as liquids for external use, pharmaceuticals, etc., and as the components of the skin externalizing agent for whitening, components according to the form of the skin externalizing agent for whitening, for example, purified water, lower alcohol Polyhydric alcohols, hydrocarbons, oils, fats, silicones, surfactants, thickeners, pigments, pigments, preservatives, cosmetic ingredients, fragrances, and the like can be used as long as the effects of the present invention are not impaired.

[0029]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of Micromelm minutum extract and Micromelm Pvecens extract Micromerum minutum root, micromelm Pvecens leaves and branches were dried and pulverized to 10 g each.
100 m of ethyl alcohol with a water content of 50% (v / v)
l, extraction was carried out at room temperature for 3 days, followed by filtration. The obtained filtrate was left to mature for about one week, and filtered again to obtain a micromelum minutum extract and a micromelm pubessens extract. At this time, the dry solid content was 2.3% for the micromelum minutum extract and 2.6% for the micromelum pavement extract.

Reference Example 2 Production of Plant Extract 10 g each of Licorice (JP), Sohakuhi (JP), and Kujin (Clara) (JP) have a water content of 50% (v
(V) 100 ml of ethyl alcohol was added, extraction was performed at room temperature for 3 days, followed by filtration. The obtained filtrate was left to mature for about one week, and filtered again to obtain each plant extract. . At this time, the dry solid content was 2.
The results were 0%, 1.8% for soybean and 2.8% for kudin.

Test Example 1 Tyrosinase Activity Inhibition Test The micromelum minutum extract obtained in Reference Example 1 by the following method, and a plant obtained in Reference Example 2 already known to have a tyrosinase activity inhibitory action as a comparative example With respect to the extract, the tyrosinase activity inhibition rate of the material alone or in combination thereof was examined. That is, an enzyme solution [10 mg of tyrosinase (28,000 units, manufactured by Sigma) in 0.1 M phosphate buffer (pH 6.8) 20
dissolved in 0.1 ml] and added 0.1 ml,
M phosphate buffer (pH 6.8) to make 4.0 ml,
This was incubated at 25 ° C. for 10 minutes.

Next, the substrate solution [L-DOPA (Tokyo Kasei) 198.
0 mg in 0.1 M phosphate buffer (pH 6.8) 100 m
dissolved in 1], and reacted for 10 minutes. After the reaction, absorbance at 475 nm (OD _S )
Was measured. Similarly, the absorbance (OD _HE ) and the absorbance (OD _B ) when the reaction was performed using the enzyme inactivated by heating and when no sample was added were calculated, and the activity inhibition rate of tyrosinase activity was calculated from the following equation. did.

[0034]

(Equation 1)

(Result)

[Table 1]

As is clear from Table 1, the micromelm
When a minutum extract and a whitening agent are combined, the tyrosinase activity inhibitory effect is higher than when the micromelum minutum extract or the whitening agent is used alone, and more than when the known whitening agents are used in combination. high,
It showed a synergistic whitening effect. Therefore, the skin external preparation for skin whitening of the present invention, which is a combination of a micromelum minutum extract and a whitening agent, exerts an extremely excellent inhibitory effect on melanin production by applying the same to the skin, resulting in blackening of the skin due to sunburn, spots, Effectively suppress freckles.

Test Example 2 Test for Pigmentation Inhibition Effect The chemicals shown in Table 2 were diluted with purified water containing 15% of ethyl alcohol and 15% of dipropylene glycol, and applied to the back of a colored guinea pig to suppress pigmentation by ultraviolet rays. The effect was investigated. Table 2 shows the results.

(Test method) Colored guinea pig (10 per group)
) Were shaved and irradiated with ultraviolet light under anesthesia. Ultraviolet irradiation is performed by using FL20S / BLB lamp manufactured by Toshiba Corporation and F
Three L20S.E30 lamps were simultaneously irradiated, and the amount of ultraviolet rays was 0.5 J / cm ² . The sample was thoroughly rubbed 0.2 ml each in four places on the back of the guinea pig 24 hours before, immediately after, 12 hours after and 24 hours after the ultraviolet irradiation. The application site was thoroughly washed with warm water before ultraviolet irradiation. Ten days after irradiation, the extent of pigmentation was observed.

(Evaluation Criteria) [Score] [State] 0: No pigmentation is observed at all 1: Very slight pigmentation is observed 2: Pigmentation is observed but the boundary with the non-irradiated part is not clear 3: Pigmentation is observed, and the boundary with the non-irradiated part is clear

According to the above evaluation criteria, each score is 1
Count how many out of 10 guinea pigs are below the score,
The determination was made according to the following criteria.

(Judgment Criteria) <Judgment> <Contents> Excellent Out of ten, the number of guinea pigs with a score of 1 or less is 8 or more. Effectiveness The number of guinea pigs with a score of 1 or less out of 10 is 6 to 7. Moderately effective Among 10 animals, the number of guinea pigs with a score of 1 or less is 4 to 5 animals. Ineffective Out of 10 animals, the number of guinea pigs with a score of 1 or less is 3 or less.

[0042]

[Table 2]

From the results in Table 2, it can be seen that the combination of the micromelum probence extract with mannitol, vitamin E linoleate, dipotassium glycyrrhizinate, and 2-hydroxy-4-methoxybenzophenone is more effective than using each alone. Pigmentation was suppressed. Therefore, it was clarified that the skin whitening agent for external use of the present invention, which contains the micromelum probence extract and a medicinal agent, suppresses pigmentation of the skin by applying it to the skin.

Test Example 3 Whitening Effect Test A test cream having the composition shown in Table 3 and the following production method was prepared, and a whitening effect test was conducted.

(Production method) Components (1)-(6) and (11)-(14) are mixed and heated to 70 ° C. B. Components (7)-(10) and (15) are mixed and heated to 70 ° C. C. B was added to A, mixed, and cooled to obtain a cream.

(Test Method) 27 to 30
A panel of fifteen 54-year-old women, twice daily, morning and night,
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The beautiful skin effect of the application was evaluated according to the following criteria.

(Evaluation Criteria) <Evaluation> <Contents> Effective Skin dullness became inconspicuous. Slightly effective The dullness of the skin became less noticeable. Ineffective No change from before use.

(Result)

[Table 3]

As shown in the results in Table 3, when the extract of micromelum pvesense, the extract of licorice, the extract of Japanese gourd, the extract of vitamin E acetate, the extract of aloe, and the 2-ethylhexyl 4-methoxycinnamate were effective. It was able to prevent and improve the skin dullness. Therefore, it was clarified that the skin whitening agent for external use of the present invention comprising the micromelum pvesence extract and a medicinal agent exhibited an excellent whitening effect when applied to the skin.

Example 1 Lotion: (Formulation) (%) (1) Micromelum minutum extract * 1 10.0 (2) Licorice extract * 2 0.5 (3) Cysteine * 3 0.01 (4) Glycerin 5.0 (5) 1,3-butylene glycol 6.5 (6) Polyoxyethylene (20EO) sorbitan 1.2 Monolaurate (7) Ethyl alcohol 8.0 (8) Preservative 9) Appropriate amount of fragrance (10) Remaining amount of purified water * 1 Produced in Reference Example 1 * 2 Produced in Reference Example 2 * 3 Wako Pure Chemical Industries

(Production method) Components (6) to (9) are mixed and dissolved. B. Components (1) to (5) and (10) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Example 2 Lotion: (Formulation) (%) (1) Micromelm Pvesense extract * 1 2.0 (2) Ougon extract * 2 0.5 (3) Citric acid 0.1 (4) Citric acid Sodium acid 0.3 (5) Acetic acid-dl-α-tocopherol * 3 0.05 (6) 1,3-butylene glycol 4.0 (7) Polyoxyethylene (60EO) hydrogenated castor oil 1.0 (8) Ethyl alcohol 15.0 (9) Preservative appropriate amount (10) Fragrance appropriate amount (11) Purified water balance * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Sigma

(Production method) A. Components (5) to (10) are mixed and dissolved. B. Components (1) to (4) and (11) are mixed and dissolved. C. A and B were mixed to obtain a lotion.

Example 3 Emulsion: (Formulation) (%) (1) Polyoxyethylene (10EO) Sorbitan 1.0 Monostearate (2) Polyoxyethylene (60EO) Sorbit 0.5 Tetra Oleate (3) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) 4-Ethylhexyl 4-methoxycinnamate * 12 0.0 (8) Micromelm Minutum extract * 2 5.0 (9) Micromelm Pvesense extract * 3 5.0 (10) Dipotassium glycyrrhizinate * 4 0.1 (11) Carboxyvinyl polymer 0.1 (12) Water Sodium oxide 0.05 (13) Ethyl alcohol 5.0 (14) Preservative appropriate amount (15) Perfume appropriate amount (16) Purified water balance * 1 Givaudan * 2 Manufactured in Reference Example 1 * 3 Manufactured in Reference Example 1 * 4 Maruzen Pharmaceutical

(Production method) A. Components (1) to (7) and (14) are mixed by heating.
Keep at 0 ° C. B. Heat-mix components (8) to (12) and (16),
Keep at 70 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, (13) and (15) were added and uniformly mixed to obtain an emulsion.

Example 4 Ointment: (Formulation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Micromelm Minutum Extract * 1 10.0 (6) Micromelum Pvesense extract * 2 10.0 (7) Sophora oleracea extract * 3 1.0 (8) L-ascorbyl magnesium * 4 1.0 (9) 2-hydroxy-4 -Methoxybenzophenone * 5 0.05 (10) Remaining purified water * 1 Manufactured in Reference Example 1 * 2 Manufactured in Reference Example 1 * 3 Manufactured in Reference Example 2 * 4 Nikko Chemicals * 5 Wako Pure Chemical Industries

(Production method) A. A part of components (3), (4) and (10) are mixed by heating and kept at 75 ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. C was dissolved in the remainder of (10) while cooling (5)
To (8) was added to obtain an ointment.

Example 5 Pack: (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Micromelm Minutum extraction Product * 1 0.05 (6) Aloe extract * 2 3.0 (7) Preservative 0.2 (8) Fragrance 0.1 (9) Remaining purified water * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical Co., Ltd.

(Production method) A. Mixing components (1), (3), (4) and (9),
Heat to 70 ° C. and stir. B. Mix components (2), (7) and (8). C. The above B was added to the above A, mixed, cooled, and (5) and (6) were uniformly dispersed to obtain a pack.

Example 6 Detergent: (Formulation) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl alcohol 1.5 (6) Purified lanolin 1.0 (7) Fragrance 0.1 (8) Preservative 0.2 (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) Micromelm Pvesense extract Material * 1 0.5 (12) Acetic acid-dl-α-tocopherol * 2 0.05 (13) Purified water Remaining amount * 1 Manufactured in Reference Example 1 * 2 Sigma

(Production Method) Mix components (9), (10) and (13) and mix
Heat to ° C. B. Ingredients (1) to (6), (8) and (12), 70
Heat to ° C. C. The above B was added to the above A, kept at 70 ° C. for a while, cooled to 50 ° C. after the reaction was completed, and the components (7) and (1)
1) was added and cooled to obtain a washing agent.

Example 7 Gel Ointment: (Formulation) (%) (1) Carboxyvinyl Polymer 1.0 (2) Triethanolamine 1.0 (3) 1,3 Butylene Glycol 10.0 (4) Micromelum Minutum Extraction Product * 1 15.0 (5) Micromelm Pvesense extract * 2 15.0 (6) Ergocalciferol * 3 0.001 (7) Chamomile extract * 4 10.0 (8) Remaining purified water * 1 Reference Manufactured in Example 1 * 2 Manufactured in Reference Example 1 * 3 Sigma * 4 Maruzen Pharmaceutical

(Production Method) Components (1) and (3) to (8) are mixed and dissolved. B. Component (2) was added to A and mixed to make a uniform, and a gel ointment was obtained.

Example 8 Lipstick: A lipstick was prepared according to the following formulation and the following production method. (Prescription) (%) (1) Micromelum minutum extract * 1 0.03 (2) beta-carotene * 2 0.02 (3) dibutylhydroxytoluene * 3 0.001 (4) Red No. 202 0.2 (5 ) Candelilla wax 9.0 (6) Solid paraffin 8.0 (7) Beeswax 5.0 (8) Carnauba wax 5.0 (9) Lanolin 11.0 (10) Isopropyl myristate 10.0 (11) Purification Castor oil remaining * 1 Manufactured in Reference Example 1 * 2 Wako Pure Chemical Industries * 3 Sigma

(Production method) After heating and dissolving the components (2), (3) and (5) to (11), the mixture is kneaded with three rollers. B. After adding the components (1) and (4) to A, the mixture is kneaded again with three rollers. C. B was cooled and molded to obtain a lipstick.

Example 9 Cream: A cream was prepared according to the following formulation and the following production method. (Prescription) (%) (1) Polyoxyethylene (40EO) monostearate 2.0 (2) Glycerin monostearate (self-emulsifying type) 5.0 (3) Stearic acid 5.0 (4) Behenyl alcohol 0.5 (5) Squalane 15.0 (6) Cetyl isooctanoate 5.0 (7) 2-Ethylhexyl 4-methoxycinnamate * 1 3.0 (8) 1,3-butylene glycol 5.0 (9) Micromelum Pvesense extract * 2 0.5 (10) Dipotassium glycyrrhizinate * 3 0.2 (11) Chamomile extract * 4 0.1 (12) 2-Hydroxy-4-methoxybenzophenone * 5 0.1 (13) Appropriate amount of perfume (14) Appropriate amount of preservative (15) Remaining purified water * 1 Givaudan * 2 Manufactured in Reference Example 1 * 3 Maruzen Pharmaceutical * 4 Maruzen Pharmaceutical 5 manufactured by Wako Pure Chemical Industries, Ltd.

(Production Method) The components (1) to (8) and (14) are heated and dissolved at 70 ° C. B. Heat components (12) and (15) to 70 ° C. C. Add A to B and cool. D. Components (9) to (11) and (13) were added to C to obtain a cream.

[0068]

EFFECTS OF THE INVENTION The skin whitening preparation of the present invention exerts a high inhibitory effect on melanin production and skin pigmentation, and is effective in preventing and improving skin darkening due to sunburn, spots and freckles. And is extremely useful in beauty and medicine.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/025 A61K 7/025

Claims (6)

[Claims] (1) The following components (A) and (B): (A) Micromelum
(B) a whitening agent, an active oxygen remover, an antioxidant, an anti-inflammatory,
An external preparation for whitening skin, comprising one or more kinds of medicinal agents selected from ultraviolet inhibitors. 2. A whitening agent comprising glabridine, glabrene,
Liquiritin, isoliquiritin and liquorice extract containing them, vitamin C and its derivatives and salts thereof, hydroquinone and its derivatives and salts thereof, cysteine and its derivatives and salts thereof, glutathione, placenta extract, sempukuka extract and calyxium extract , Sampens extract, Sow arbor extract, Touki extract, Ibukitrano extract, Clara extract, Hawthorn extract,
The whitening skin external preparation according to claim 1, which is selected from a white lily extract, a hop extract, a wild rose extract, and a yoquinin extract. 3. An active oxygen scavenger comprising carotenoids such as SOD, mannitol, beta-carotene, hydroquinone, bilirubin, cholesterol, tryptophan, histidine, quercetin, quercitrin, catechin,
A catechin derivative, gallic acid, a gallic acid derivative, a plant extract containing flavonoids in its components, such as a gougon extract and a ginkgo extract, a saxifrage extract, a gokahi extract, a yasazitsu extract and a dicopi extract. An external preparation for whitening skin according to claim 1. 4. An antioxidant comprising vitamin A and derivatives thereof and salts thereof, vitamin B and derivatives thereof and salts thereof, vitamin C and derivatives thereof and salts thereof, vitamin D and derivatives thereof The whitening skin external preparation according to claim 1, which is selected from derivatives and salts thereof, vitamin E and derivatives thereof, salts thereof, glutathione and derivatives thereof, and salts thereof, dibutylhydroxytoluene and butylhydroxyanisole. 5. An anti-inflammatory agent comprising glycyrrhizic acid, glycyrrhetinic acid, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene and derivatives thereof, salts thereof, chondroitin sulfate and salts thereof, ε-aminocapron Acid, zinc oxide, diclofenac sodium, arnica extract, aloe extract, hypericum extract, chamomile extract, salvia extract, sicon extract, birch extract, touki extract, mukuroji extract, mugwort extract and eucalyptus extract The skin whitening agent for external use according to claim 1, which is selected from products. 6. The method according to claim 6, wherein the ultraviolet light inhibitor is para-aminobenzoic acid,
Ethyl para-aminobenzoate, glyceryl para-aminobenzoate, amyl N, N-dimethylpara-aminobenzoate,
2-ethylhexyl N, N-dimethylparaaminobenzoate, 2-ethylhexyl salicylate, ethylene glycol salicylate, homomenthyl salicylate, 2-ethylhexyl 4-methoxycinnamate, ethoxyethyl 4-methoxycinnamate, 4-methoxysilicate Potassium cinnamate,
Methyl 4-5-diisopropylcinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, 2
-Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenonesulfonic acid, 2-
Sodium hydroxy-4-methoxybenzophenonesulfonate, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'-dihydroxy-4,
Sodium 4'-dimethoxybenzophenone-5-sulfonate, 2-4-dihydroxybenzophenone, 2,
2 ', 4,4'-tetrahydroxybenzophenone, 2
-(2-hydroxy-5-methylphenyl) -benzotriazole, urocanic acid, ethyl urocanate, 4-
The skin whitening external preparation according to claim 1, which is selected from t-butyl-4'-methoxy-dibenzoylmethane, titanium oxide, zinc oxide and iron oxide.