JP2001342112A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation which inhibits melanin formation and exhibits both bleaching effect and skin-roughening ameliorative effect not only effective in the prophylaxis against pigmentation, stain, freckle, chloasma or the like after sunburn but also effective in the improvement in contact dermatitis, psoriasis or other dermatosis, e.g. skin-roughening, skin-drying liable to get rough or the like. SOLUTION: This skin care preparation is obtained by formulating Akebia quinata or its solvent extract and one or more kinds of plants selected from the group consisting of Syzygium aromaticum L., Cinnamomum cassia, Alisma Plantago-aquatica L. var. orientale, Zingiber officinale and Coptis japonica or its solvent extracts as active ingredients.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for whitening skin and an external preparation for improving skin roughness.
Suppresses the production of melanin and prevents pigmentation, spots,
The present invention relates to an external preparation for skin having both a whitening effect and a skin roughening effect that is effective in preventing freckles and liver spots, and is also effective in improving skin diseases such as contact dermatitis, psoriasis, and other rough and rough skin.

[0002]

2. Description of the Related Art There are some unclear points about the mechanism of the occurrence of skin spots and the like. Is produced, which is believed to be abnormally deposited in the skin. This melanin pigment, which causes the coloring of the skin, is produced in melanin-producing granules (melanosomes) in melanocytes (melanocytes) between the epidermis and the dermis, and the produced melanin diffuses into neighboring cells by osmosis. The biochemical reaction in this melanocyte is estimated as follows. That is, tyrosine, which is an essential amino acid, is converted into dopaquinone by the action of the enzyme tyrosinase, and the process in which it is converted to black melanin via a red pigment and a colorless pigment by an enzymatic or non-enzymatic oxidative action is a melanin pigment production process. Therefore, suppressing the action of tyrosinase, which is the first step of the reaction, is important for suppressing melanin.

[0003] However, compounds that suppress the tyrosinase action, except for hydroquinone, have very slow onset of their effects, so that the effect of improving skin pigmentation is not sufficient. On the other hand, although hydroquinone is recognized as having an effect, its use is generally restricted because of its sensitizing properties. Therefore, in order to improve its safety, attempts have been made to use monoesters or alkyl monoethers of higher fatty acids, but the esters are not always safe because they are decomposed by hydrolyzing enzymes in the body. As for the kind, the thing which fully satisfies in terms of safety has not been obtained.

On the other hand, recently, the mechanism of the occurrence of rough skin has been elucidated biochemically. It has been pointed out that changes in the activities of proteases, particularly serine proteases such as plasmin and plasminogen activator (PA), are deeply involved in the formation of various skin diseases accompanied by rough skin and abnormal keratinization. For example, in psoriasis, which is a representative of inflammatory dyskeratosis, the presence of strong PA activity in the parakeratotic site of the affected epidermis (Haustein: Arch. Klin. Exp. Dermatol;
34, 1969) and psoriasis scales using a high-concentration salt solution
Report that A was extracted (Fraki, Hopsu-Havu: Arch. Der
matol.Res; 256,1976). PA works specifically on plasminogen, the precursor of plasmin,
It is a protease that converts it to active plasmin. There are also reports showing that a compound known as a serine protease inhibitor suppressed skin roughness (Kenj
i kitamura: J. Soc. Cosmet. Chem. Jpn; 29 (2), 1995).

[0005] In view of the above situation, the present inventors have:
As a result of examining the melanin production inhibitory effect, whitening effect and skin roughness improving effect in a wide variety of combinations of substances, one or two selected from the group consisting of akebi or its solvent extract and clove, kei, sagemodaka, ginger, and spinach. The present inventors have found that a combination of at least one plant or a solvent extract thereof has a melanin production-suppressing effect, a whitening effect, and a skin roughness-improving effect, and have completed the present invention.

[0006]

That is, the present invention relates to a plant or a solvent extract of one or more plants selected from the group consisting of Acacia catechu or a solvent extract thereof, and Oryza cinnamon, Kay, Sajimodaka, Ginger, and Orange. And / or a whitening agent characterized by containing
Alternatively, it is a skin external preparation for improving rough skin.

It is known that akebi or the solvent extract thereof used in the present invention has a beautiful skin effect, an anti-stain effect, and an anti-inflammatory effect (Japanese Patent Publication No. 01-42411). However, the extract of akebi, which is a feature of the present application,
It has been known that a combination of at least one plant selected from the group consisting of kei, sage modaka, ginger, and spinach or a solvent extract thereof exhibits particularly excellent whitening effect and skin roughness improvement effect. Did not.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.
The external preparation for skin of the present invention contains, as active ingredients, akebi or a solvent extract thereof and one or more plants or solvent extracts thereof selected from the group consisting of Acacia catechu, kei, sage modaka, ginger, and spinach. . Akebia (Akebia quinata Decne) used in the present invention is a plant classified in the genus Akebi of the genus Akebi, and its stem, root, leaves,
Whole plants, such as seeds, are suitable for the present invention. In the present invention, stems, leaves, seeds and the like of closely related species and subspecies such as Akebia quinata Decne and Akebia pentaphylla Makino which are congeners of Akebia quinata Decne are also preferably used. be able to.

[0009] Eugeni (Eugeni) used in the present invention
a caryophyllata Thunberg) is a plant classified in the genus Adec of the family Myrtaceae, and the bud portion is mainly suitable for the present invention. The bud is used as a crude drug, and is called Caryophylli Flos.

[0010] Cinnampmum Cas used in the present invention
sia Blume) is a plant classified in the camphor tree genus, and its stem bark and branch bark are mainly suitable for the present invention. In addition, plants belonging to the same genus as kei can be suitably used. The stem bark and the bark of calyx and its congeners are used as crude drugs and are called calyx (Cinnamoni Cortex).

[0011] The alga (Alisma) used in the present invention
plantago aquatica L. varzorientate Samuels) is a plant classified in the genus Sadomodaka of the family Omodaca, and its rhizome portion is mainly suitable for the present invention. The rhizome part of Sadiomodaka is used as a crude drug, and Taksha (Alismati)
s Rhizoma).

Ginger used in the present invention (Zingiber o
fficinate (L.) Rosc.) is a crude drug name of a plant classified in the ginger family of the ginger family, and the rhizome portion is mainly suitable for the present invention. In addition, a plant belonging to the same genus of ginger can be suitably used. The rhizome of ginger and its congeners is used as a crude drug, and ginger (Zingib
eris Rhizoma).

The spinach used in the present invention (Coptidis j
aponica (THUMB.)) is a crude drug name of a plant classified in the family Ranunculaceae, and the rhizome portion is mainly suitable for the present invention. Our water is kikubaouren, seribaouren,
Although classified into three varieties of Koserivourouren, all of them are suitable for the present invention. The rhizome part of spinach is used as a crude drug and is called spinach (Coptidis Rhizoma).

These plants can be used either raw or dried, but are preferably used as a dry powder or a solvent extract from the viewpoints of usability, formulation and the like.

The above plant extract can be obtained by a conventional method. For example, the plant extract can be obtained by immersing or heating and refluxing the plant with an extraction solvent, followed by filtration and concentration. As the extraction solvent, any solvent can be used as long as it is a solvent usually used for extraction. For example, organic solvents such as alcohols such as methanol and ethanol, aqueous alcohols, acetone, ethyl acetate, and 1,3-butylene glycol are used. And water can be used alone or in combination. The extract may be obtained by using the above-mentioned solvent and subjecting it to a treatment such as partitioning or purification such as chromatography. The external preparation for skin containing the plant extract thus obtained as an active ingredient has high safety, excellent whitening effect and improvement of skin roughness.
Has a preventive effect.

The amount of the plant or its extract in the present invention is 0.00001 to 0.00001 as dry matter in the total amount of the external preparation.
It is 20.0% by weight, preferably 0.0001 to 10.0% by weight. If the amount is less than 0.00001% by weight, the effects of the present invention cannot be sufficiently exhibited, and if it exceeds 20.0% by weight, it is difficult to formulate the composition, which is not preferable. Also, 10.
Even if it is added in an amount of 0% by weight or more, the effect is not so greatly improved.

The external preparation for skin of the present invention includes, in addition to the above essential components, components usually used in external preparations for skin such as cosmetics and pharmaceuticals as long as the effects of the present invention are not impaired.
Moisturizing agents, antioxidants, oily components, ultraviolet absorbers, emulsifiers, surfactants, thickeners, alcohols, powder components, coloring materials, aqueous components, water, various skin nutrients, etc. as needed can do.

For example, providing a moisturizing effect is useful for the purpose of preventing aging due to drying of the skin. In this case, for example, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, hexylene glycol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, acetylhyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen,
Cholesteryl-12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate,
Moisturizing agents such as short-chain soluble collagen, diglycerin (EO) PO adduct, lycopodium extract, yarrow extract, and melilot extract can be added to the skin external preparation of the present invention.

In order to further provide a whitening effect, placenta extract, glutathione, Saxifraga extract, arbutin,
Skin lightening agents such as kojic acid, ellagic acid, lucinol, extract of Cola de Caballo, extract of ginger plant Lumpuyan, and the like can be blended in the skin external preparation of the present invention.

In order to impart an anti-inflammatory effect, an anti-inflammatory agent such as a glycyrrhizic acid derivative, a glycyrrhetinic acid derivative, a salicylic acid derivative, hinokitiol, zinc oxide, and allantoin can be added to the external preparation for skin of the present invention.

In addition, activators such as royal jelly, photosensitizers, cholesterol derivatives, calf blood extract, nonylate valenylamide, nicotine, etc. are used for the purpose of alleviating the adverse effects of ultraviolet rays on the skin and further suppressing the skin aging. Acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, gingerone, canthari tincture, itctamol, caffeine, tannic acid, α-borneol, nicotinic acid tocophenol, inositol hexanicotinate, cyclandate, cinnarizine, tolazoline, Acetylcholine, verapamil, cepharanthin,
A flow-promoting agent such as γ-oryzanol, an antiseborrheic agent such as sulfur and thianthol, and the like can be added to the skin external preparation of the present invention.

In addition, for various purposes, the following components can be used: muk roe extract component, psyllium extract component, oak extract component, sicon extract component, peony extract component, assembly extract component, birch extract component, sage extract component, loquat extract component, carrot extract component, Aloe extract, mallow extract, iris extract, grape extract, yokuinin extract, loofah extract, lily extract, saffron extract, senkyu extract, ginger extract, hypericum extract, ononis extract, rose Marie extract ingredients,
Garlic extract, pepper extract, licorice extract,
Chimney extract, corn extract, marjoram extract, yakisou extract, karin extract, psycho extract, edible maize extract, emicaceae extract, whey extract and the like can be blended in the skin external preparation of the present invention. .

Further, in order to impart unique effects possessed by each vitamin, vitamin A such as vitamin A, β-carotene, retinol, retinol acetate, retinol propionate, retinol palmitate, riboflavin,
Vitamin B2 such as riboflavin butyrate, flavin adenine nucleotide, vitamin B6 such as pyridoxine hydrochloride and pyridoxine dioctanoate, ascorbic acid,
Vitamin Cs such as magnesium ascorbate, ascorbic acid glucoside, ascorbic acid dipalmitate, ascorbic acid-2-sodium sulfate, ascorbic acid phosphate, DL-α-tocophenol-ascorbic acid diester dipotassium phosphate;
Pantothenic acids such as calcium pantothenate, pantoenyl alcohol, pantoenyl ether ether, and acetyl pantothenyl ethyl ether; vitamin Ds such as ergocalciphenol and cholecalciphenol; nicotinic acids such as nicotinic acid, nicotinamide, and benzyl nicotinate , Α-tocopherol acetate, tocopherol acetate, nicotinic acid-α-tocopherol, succinic acid-α-tocopherol and other vitamins E, vitamin P, biotin and other vitamins can be incorporated into the skin external preparation of the present invention.

Further, disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, malic acid,
Sequestering agents such as trisodium hydroxyethyl triacetate,
Tranexamic acid and its derivatives, arginine, lysine, ornithine, glutamine, alanine, histidine,
Leukine, isoleucine, methionine, threonine, phenylalanine, tryptophan, cysteine, cystine, tyrosine, proline, aspartic acid, glutamic acid, amino acids such as serine and derivatives thereof, trimethylglycine, polypeptides such as polyaspartic acid, etc. Agent.

The external preparation for skin of the present invention can be widely applied to cosmetics, pharmaceuticals, and quasi-drugs, particularly preferably cosmetics, applied to the outer skin. Any solution can be used as long as it can be applied to a solution system, a solubilizing system, an emulsifying system, a powder dispersion system, a water-oil two-layer system, and a water-oil-
An arbitrary dosage form such as a three-layer powder system, an ointment, a gel, and an aerosol is applied.

The form of use is arbitrary, for example, lotion, cream, emulsion, lotion, pack, ointment,
In addition to mousse and soap, any cosmetics such as foundations and lipsticks, bath preparations and the like may be used as long as they are conventionally used for external preparations for the skin, and the dosage form is not particularly limited.

[0027]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the technical scope of the present invention is not limited by these examples. In addition, all compounding amounts are weight%. Prior to the examples, test methods and results of a melanin-suppressing effect, a whitening effect, and a skin roughness-improving effect of the external preparation for skin according to the present invention will be described.

Test Methods for Melanin Suppressing Effect and Whitening Effect and Their Results Preparation of Sample 50 g of a stem portion of Akebia (Akebia quinata Decne) was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 2.28 g of an ethanol extract. In addition, the bud part 5 of Eugenia caryophyllata Thunberg
0 g was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 3.15 g of an ethanol extract. Kay (Cinnam
50 g of the stem bark of pmum Cassia Blume) was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 2.96 g of an ethanol extract. Sage Modaka (Alisma plantago)
rhizome part 50 of aquatica L. varzorientate Samuels)
g of the extract was immersed in ethanol at room temperature for one week, and the extract was concentrated to obtain 2.52 g of an ethanol extract. Ginger (Zi
ngiber officinate (L.) Rosc.) was immersed in ethanol for 1 week at room temperature, and the extract was concentrated to obtain 2.65 g of an ethanol extract. 50 g of a rhizome rhizome (Coptidis japonica (THUMB.)) Was immersed in ethanol at room temperature for 1 week, and the extract was concentrated to obtain 3.26 g of an ethanol extract. 1% of these extracts in DMSO
After dissolving the solution, the concentration was adjusted by diluting the solution, and the following experiment was performed using the solution.

2. Cell culture method B16 melanoma cultured cells derived from mice were used. 1
0% FBS and theophylline (0.09 mg / ml)
Was cultured in a CO ₂ incubator (95% air, 5% carbon dioxide) at 37 ° C. in an Eagle MEM medium containing After 24 hours of culture, the plant extract solution was adjusted to a final concentration of 1
0 ^-2 to 10 ^-5 % by weight was added. After the addition, the culture was further continued for 3 days, and the visual determination of the amount of melanin production was performed by the following method.

3. Visual measurement of the amount of melanin A diffusion plate was placed on the lid of the plate of the well, the amount of melanin in the cells was observed with an inverted microscope, and compared with a sample without the plant extract (reference). Table 1 shows the results.

<Judgment Criteria> ：: White (melanin content) Δ: Slightly white (melanin content) ×: Standard (melanin content)

[0032]

[Table 1] ───────────────────────────────── Test Melanin production visual evaluation ───────濃度 Concentration (% by weight) 10 ^-5 10 ^-4 10 ^-3 10 ^-2 ────────────────────────── ─────── Akebi extract × × × ○ Butterfly extract × × × × Cay extract × × × × Sadow mosquito extract × × × × Ginger extract × × × × Spinach extract × × × × Extract 0.01% + Akebi extract × × ○ ○ Cay extract 0.01% + Akebi extract × × ○ ○ Sadiomodaka extract 0.01% + Akebi extract × × △ ○ Ginger extract 0.01% + Akebi extract × × △ ○ Orange extract 0.01% + akebi extract × × ○ ○ ─────────────────────────────────

4. Skin whitening effect test [Test method] 96 days of subjects exposed to sunlight in summer for 4 hours (2 hours a day for 2 days) were subjected to 5 days after the day of sun exposure for the inner skin of the upper arm. It was applied once every morning and evening for four weeks. The panel was divided into eight groups, each group being divided into twelve groups, and the test was performed according to the following formulation. <Production method> An aqueous phase and an alcohol phase are respectively prepared, and then both are mixed and solubilized.

[Evaluation Method] The lightening effect after use was determined based on the following criteria. <Judgment criteria> ：: When the ratio showing significant effect and effectiveness among the subjects is 80% or more 割 合: The ratio showing significant effect and effectiveness among the subjects is 50% or more
Less than 80% △: The proportion of the test subjects showing excellent and effective is 30% or more
Less than 50% ×: The proportion of subjects showing excellent and effective is less than 30%

[0035]

[Table 2] 薬 剤 Drug (Blending amount, wt%) Effect ──────── ───────────────────── No additive × Akebi extract (0.1%) △ Kay extract (0.1%) × Butterfly extract (0.1%) × Sadow mosquito extract (0.1%) × ginger extract (0.1%) × spinach extract (0.1%) × silica extract (0.1%) + akebi extract (0.1%) ○ butterflies extract (0.1%) + akebi extract ( 0.1%) ○ Sadow mosquito extract (0.1%) + akebi extract (0.1%) ○ ginger extract (0.1%) + akebi extract (0.1%) ○ spinach extract (0.1%) + akebi extract (0.1%) ) ○ ─────────────────────────────

As is evident from Table 2, the effect after exposure to sunlight is better when the combination of the akebi extract and the plant extract of the present invention is combined to prevent the deposition of excess melanin pigment and to make the color black. It has been found to prevent

Test Method for Result of Improving Skin Roughness and Results As a sample, a stem portion of Akebia quinata Decne (50 g) was immersed in hot water, and an extract obtained by filtration and a plant such as silica were immersed in hot water. Then, using a lotion having a formulation shown in Tables 3 and 4 containing the extract obtained by filtration, the effect of improving skin roughness on a human body panel was evaluated. That is,
A replica of the skin (face cheek) of a healthy female was collected using a replica agent, and the skin surface morphology was observed with a microscope (17 ×). Based on the skin crest state and the peeling state of the stratum corneum, 110 persons determined to have a rough skin score of 1 or 2 based on the following criteria are classified as rough skin panels, divided into 11 groups of 10 persons, and each sample lotion in each group. Was assigned. A sample lotion was applied to the face twice a day for 4 weeks, and after 4 weeks, the skin condition was observed again according to the replica method described above, evaluated according to the criteria, and each person was examined. Table 5 shows the results.

<Replica Judgment Criteria> 1: Elimination of skin sulcus and skin ridges, and turning-up of a wide range of stratum corneum are recognized. 2: The crevices and crevices are unclear and the horny layer is turned up. 3: Skin sulcus and skin ridge are recognized, but flat. 4: Skin sulcus and skin hills are clear. 5: The skin groove and skin hills are clear and well-ordered.

[0039]

[Table 3] {Product of the present invention 1 2 3 4 5} ──────────────── Akebi extract 2.0 2.0 2.0 2.0 2.0 Silica extract 2.0 − − − − Aesculus extract − 2.0 − − − Sajimodaka extract − − 2.0 − − Ginger extract Substance---2.0-Ouren extract----2.0 Glycerin 1.0 1.0 1.0 1.0 1.0 1,3-butylene glycol 4.0 4.0 4.0 4.0 4.0 Ethanol 7.0 7.0 7.0 7.0 7.0 Polyoxyethylene (20 mol) Oleyl alcohol 0.5 0.5 0.5 0.5 0.5 Purified water residue residue residue residue residue residue ───────────────────────────

[0040]

[Table 4] {Comparative product 1 2 3 4 5 6}ケ Akebi extract 2.0 − − − − − Silica extract − 2.0 − − − − Butterfly extract − − 2.0 − − − Sajimodaka extract − − − 2.0 − − Ginger extract − − − − 2.0 − Spinach extract − − − − − 2.0 Glycerin 1.0 1.0 1.0 1.0 1.0 1.0 1,3-butylene glycol 4.0 4.0 4.0 4.0 4.0 4.0 Ethanol 7.0 7.0 7.0 7.0 7.0 7.0 Polyoxyethylene (20 mol) Oleyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 Purified water Residue Residue Residue Residue Residue Residue ─────────────────────────── ──

[0041]

[Table 5] ─────────────────────────────── Inventive product Comparative product Replica evaluation ──────── {1 2 3 4 5 5 1 2 3 4 5 6} ───── 100 000 000 010 010 230 213 211 213 445 655 533 323 324 455 224 434 444 424 000 0 0 1 5 3 3 1 2 4 1 0 0 0 0 0 0

As can be seen from Table 5, the lotion of the present invention showed an excellent effect of improving rough skin as compared with the lotion of the comparative product.

[0043] (Preparation method) Propylene glycol, water extract of Akabi and caustic potash are added to ion-exchanged water and dissolved, and the mixture is heated and maintained at 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

[0044] (Production method) Add propylene glycol to ion-exchanged water,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, homogenized with a homomixer, and cooled to 30 ° C. with good stirring.

[0045] (Preparation method) Soap powder and borax are added to ion-exchanged water and heated to 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 4 Emulsion (Formulation) Weight% Stearic Acid 2.5 Cetyl Alcohol 1.5 Vaseline 5.0 Liquid Paraffin 10.0 Polyoxyethylene (10 mol) Monooleate 2.0 Polyethylene Glycol 1500 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (trade name: Carbopol 941, BF Goodrich Chemical company) Ethyl akebiacetate extract 0.02 Ethyl sodimodaka acetate extract 0.02 Retinol 0.1 Sodium bisulfite 0. 01 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water residue (Preparation method) Dissolve the carboxyvinyl polymer in a small amount of ion-exchange water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, and the mixture is heated and dissolved and maintained at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsification is performed, phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

[0047] (Production method) Add propylene glycol to ion-exchanged water,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The aqueous phase is gradually added while stirring the oil phase, and after uniform emulsification with a homomixer,
Cool to 30 ° C with good stirring.

Example 6 Jelly (Formulation) Weight% 95% Ethyl Alcohol 10.0 Dipropylene Glycol 15.0 Polyoxyethylene (50 mol) Oleyl Alcohol Ether 2.0 Carboxyvinyl Polymer 0.05 (trade name: Carbopol) 940, BFGoodrich Chemical company) caustic soda 0.15 L-arginine 0.1 akebi 30% ethanol extract 0.1 spinach 30% ethanol extract 0.1 xylitol 1.0 spinach extract 0.1 sodium bisulfite 0.01 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchanged water Residue (Preparation method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while plant extract and polyoxyethylene (50 mol) oleyl alcohol ether are dissolved in 95% ethanol. To the aqueous phase. Next, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

[0049] (Production method) Dissolve A phase and B phase uniformly, and add B
Add phases and solubilize. Next, the C phase in which the akebi dry powder and the silica dry powder are dispersed is added thereto, and then filling is performed.

[0050]

As described above, the external preparation for skin of the present invention has an effect of inhibiting melanin production, and is excellent in lightening and whitening of pigmentation, spots, freckles, liver spots, etc. after sunburn. It has an effect, and also has an excellent effect in improving skin roughness and roughness.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 17/00 A61P 17/00 (72) Inventor Taiichi Nakayama 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa F-term in Shiseido Daiichi Research Center (reference) 4C083 AA111 AA112 AA122 AB032 AB152 AB352 AC012 AC022 AC072 AC122 AC132 AC182 AC242 AC342 AC392 AC402 AC422 AC432 AC442 AC482 AC542 AC582 AC622 AD092 AD112 AD202 CC03 CC05 CC07 DD12 DD32 DD41 EE16 AB032C AB33 AB57 AB71 AB81 AC01 AC04 AC05 AC11 CA06 CA07 CA08 MA07 MA63 NA06 NA07 ZA89

Claims (4)

[Claims] Claims: 1. An active ingredient comprising akebi or a solvent extract thereof, and one or more plants selected from the group consisting of butterflies, silk, sage modaka, ginger, and spinach, or a solvent extract thereof. A topical skin whitening agent. 2. An active ingredient comprising: akebi or a solvent extract thereof, and one or more plants selected from the group consisting of butterflies, kei, sage modaka, ginger, and spinach or a solvent extract thereof. A topical skin preparation for improving skin roughness. 3. An active ingredient comprising: akebi or a solvent extract thereof, and one or two or more plants selected from the group consisting of butterflies, silk, sage modaka, ginger, and spinach, or a solvent extract thereof. A skin whitening agent for improving skin whitening and rough skin. 4. The compounding amount of the akebi or the solvent extract thereof is 0.00001 to 20.0% by weight in terms of solid content,
The amount of one or more plants selected from the group consisting of Aspergillus niger, Kay, Sadomodaka, Ginger, and Ouren or a solvent extract thereof is 0.0001 to 20.0.
The external preparation for skin according to any one of claims 1 to 3, which is in terms of% by weight.