JPH1029927A - Antiaging agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare an antiaging agent, comprising one or more extracts from specific plants as active ingredients, capable of manifesting promoting actions on the production of collagen and preventing skin from aging and useful especially as a promoter for the production of the collagen and a cosmetic for preventing the aging. SOLUTION: This antiaging agent comprises one or more selected from among extracts obtained from plants Sambiloto (botanical name: Andrographis panicurata) and Kemukus (botanical name: Piper cubeba) as active ingredients therein. The two species of plants grow in a dry grassland, a pasture, etc., of Indonesia. The amount of the blended extracts is 0.0005-20.0wt.% preferably 0.001-10.0wt.% expressed in terms of a dry substance in the total amount of a preparation for external use. The antiaging agent is capable of preventing the skin from aging and maintaining a state of the youthful and healthy skin. The antiaging agent can be used as a basic cosmetic, a makeup cosmetic, a toiletry product, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an anti-aging agent,
More specifically, the present invention relates to an anti-aging agent that can enhance the collagen-producing ability of skin to prevent skin aging. The anti-aging agent of the present invention can be suitably used for basic cosmetics, makeup cosmetics, hair cosmetics, bath additives, and the like.

[0002]

2. Description of the Related Art Conventionally, the necessity of an anti-aging agent has been considered, but the mechanism and definition of aging have not been clarified. The measurement of the moisturizing state and the measurement of the elasticity of the skin have been performed, and the skin color has been visually observed for judgment. However, in recent years, research on aging has been advanced, and aging is an important factor as a cause of skin aging macroscopically, and furthermore, drying, oxidation, sunlight (ultraviolet rays)
The effects of aging have also been cited as direct factors related to skin aging. Specific phenomena of skin aging include:
It is known that collagen cross-linking reaction, reduction of mucopolysaccharides such as hyaluronic acid, damage of cells by ultraviolet rays, etc., but biochemical products such as mucopolysaccharides and collagen and synthetic high It has also become clear that aging of the skin cannot be sufficiently prevented only by blending a molecular product and trying to retain moisture.

[0003] Therefore, it works on fibroblasts in the skin,
By promoting the biosynthesis of collagen, which is one of the important components of the dermis, a collagen production promoter capable of preventing skin aging and having no problem in terms of safety has been desired. As a component having such a collagen production promoting action, the present inventors have found an enzyme obtained by treating an alkaline extract of low-allergen rice obtained by previously treating rice with a proteolytic enzyme with the enzyme. Decomposed products are known (Japanese Patent Application No. 7-243463, Japanese Patent Application No. 8-976).
No. 54). Further, a further substance having an excellent ability to promote collagen production has been desired.

[0004]

Means for Solving the Problems In order to solve these problems, the present inventors have examined the ability of various substances to promote collagen production. It has been found that the present invention has been completed. The plant extract of the present invention is known as a tyrosinase inhibitor, a whitening agent, an ultraviolet absorber, and the like (Japanese Patent Application Nos. 7-200467 and 7-207687), but it includes an anti-aging agent and collagen production. No application to accelerators is known. The present inventors have completed the present invention based on the above findings.

[0005] That is, the present invention is an anti-aging agent comprising one or two selected from the following plant extracts. (1) Sambiroto (scientific name: Androgra
phis panicurata) (2) Kemukus (scientific name: Piper cubeba) The anti-aging agent of the present invention is preferably a collagen production promoter.

Hereinafter, the configuration of the present invention will be described in detail. All of the plant extracts used in the present invention are plants that grow on dry grasslands, pastures and the like in Indonesia. Plant extracts used in the present invention, its leaves, stems, flowers, bark,
The xylem, seed or fruit, whole plant, or the like is obtained by immersing or heating and refluxing with an extraction solvent, followed by filtration and concentration.
The extraction solvent used in the present invention is not particularly limited as long as it is a solvent usually used for extraction. In particular, an organic solvent such as alcohols such as methanol and ethanol, aqueous alcohols, acetone, and ethyl acetate is used alone or in combination. Can be.

The amount of the plant extract in the present invention is as follows:
It is 0.0005 to 20.0% by weight, preferably 0.001 to 10.0% by weight as a dry matter in the total amount of the external preparation.
If the amount is less than 0.0005% by weight, the effects of the present invention cannot be sufficiently exerted, and if it exceeds 20.0% by weight, it is difficult to formulate the composition, which is not preferable. Further, even if the content is 10.0% by weight or more, the effect is not so much improved.

[0008] Since all of the plant extracts used in the present invention have an excellent collagen production promoting action on human skin, the anti-aging agent containing the plant extract is useful for aging skin. And can maintain youthful and healthy skin condition.

The anti-aging agent of the present invention contains, in addition to the above essential components, components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, whitening agents, moisturizing agents, antioxidants, oily components,
An ultraviolet absorber, a surfactant, a thickener, an alcohol, a powder component, a coloring material, an aqueous component, water, various skin nutrients, and the like can be appropriately compounded as necessary.

In addition, sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, caffeine, tannin, verapamil, tranexamic acid and derivatives thereof, and licorice extract Products, glabridine, hot water extract of karin fruit, various crude drugs, drugs such as tocopherol acetate, glycyrrhizic acid and derivatives or salts thereof, vitamin C, magnesium ascorbate phosphate, glucoside ascorbate, arbutin, kojic acid and the like Other whitening agents, sugars such as glucose, fructose, mannose, sucrose, trehalose and the like can also be appropriately compounded.

The present invention can be widely applied to cosmetics and quasi-drugs applied to the outer skin, particularly preferably cosmetics, and its dosage form can be aqueous solution type, solubilizing type, emulsifying type. A wide range of dosage forms can be used, such as powder, oil-liquid, gel, ointment, aerosol, water-oil two-layer systems, water-oil-powder three-layer systems, and the like. In other words, if it is a basic cosmetic, face wash, lotion,
The present invention can be widely applied to various forms such as emulsions, creams, gels, essences (packs, masks) and the like. In addition, if it is makeup cosmetics,
As a toiletry product such as a foundation, it can be widely applied to forms such as a body soap and a soap. Furthermore, quasi-drugs can be widely applied to various ointments and the like. And in these dosage forms and forms,
The form that the anti-aging agent of the present invention can take is not limited.

[0012]

EXAMPLES Next, the anti-aging agent of the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. The compounding amount is% by weight. Prior to the examples, a test method for the collagen production promoting effect of the plant extract of the present invention and the results thereof will be described.

1. Preparation of Sample (1) Sambiroto Extract 50 g of Sambiroto leaves were immersed in ethanol at room temperature for 4 days, and the extract was concentrated to obtain 2.37 g of an ethanol extract. This extract was dissolved in DMSO at 1%, the concentration was adjusted by diluting this solution, and the following experiment was performed using this.

(2) Kemucus extract 50 g of the fruit of Kemucus was immersed in ethanol at room temperature for one week, and the extract was concentrated to obtain 0.6 g of an ethanol extract. This extract was added to DMSO for 1
%, And the concentration was adjusted by diluting this solution. Using this, the following experiment was performed.

2. Test Methods and Results Human skin fibroblasts were seeded in 96-well dishes at 20,000 and 48
After culturing in RITC80-7 containing 10% FBS for a time, the medium was replaced with a medium containing 0.5% FBS, a plant extract dissolved in DMSO was added, and the cells were further cultured for 48 hours.
DMSO should be 1/200 (5 μl per 1 ml of medium)
l) Added. The extract concentration was 10 ⁻⁵ to 10 ⁻² wt%. After the culture, the medium was collected and used for collagen measurement.
Further, the amount of DNA in the petri dish was measured and used as an index of the cell number. The amount of DNA was measured by a fluorescence measurement method using H33258. Regarding the plant extract of the present invention,
0 ^-2% by weight in cytotoxicity was observed, but 10 ^-3 wt%
Showed no toxicity. Therefore, a type I carboxyterminal propeptid (Procollagen type I carboxyterminal propeptid) produced by cultured human skin fibroblasts
e: PIP) was measured by an ELISA method, and a sample containing no plant extract (control) having a PIP amount per DNA of 100 was added with a plant extract-added sample having a concentration of 10 ^-3 % by weight. Was measured and defined as collagen production promotion rate (%). Table 1 shows the results. In addition, as a reference example, the same test as described above was performed on a solvent extract of Rishimi, which is already known to have a collagen production promoting action. Table 1 also shows the results.

[0016]

[Table 1] ───────────────────────────── Test Collagen production promoting effect (%) ───────── ────────────────────Sanvilot extract 131.7 Chemex extract 115.1 Rishimi extract 124.1─────────── ──────────────────

Hereinafter, examples of the formulation of the anti-aging agent of the present invention in various dosage forms will be described as examples.

Example 1 Cream (Formulation) Stearic acid 5.0% by weight Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate 3.0 Propylene glycol 10.0 Sunbilot methanol extract 0.01 Caustic potash 0.2 Sodium bisulfite 0.01 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchanged water Residue (Preparation method) Add propylene glycol, sambilotomethanol extract and caustic potash to ion-exchanged water, dissolve and heat to maintain at 70 ° C ). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 2 Cream (Formulation) Stearic acid 2.0% by weight Stearyl alcohol 7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Chemex ethanol extract 0.05 Sodium bisulfite 0.03 Ethyl paraben 0.3 Perfume Appropriate amount Ion exchange water Residue (Production method) Ion exchange water with propylene glycol And add
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, homogenized with a homomixer, and cooled to 30 ° C. with good stirring.

Example 3 Cream (Formulation) Solid paraffin 5.0% by weight Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate 2 0.0 Soap powder 0.1 Borax 0.2 Sunbirotoacetone extract 0.05 Chemux ethanol extract 0.05 Sodium bisulfite 0.03 Ethylparaben 0.3 Perfume Appropriate amount Ion exchange water Residue (Production method) Ion exchange water Soap powder and borax are added to the mixture, and the mixture is dissolved by heating and maintained at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after emulsification.

Example 4 Emulsion (Formulation) Stearic acid 2.5% by weight Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) monooleate 2.0 Polyethylene glycol 1500 0 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 (Product name: Carbopol 941, BFGoodrich Chemical c
ompany) Sanbirotoacetic acid ethyl ester extract 0.01 Sodium bisulfite 0.01 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchange water residue (Preparation method) Dissolve the carboxyvinyl polymer in a small amount of ion-exchange water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the remaining ion-exchanged water, dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, the phase A is added, and the mixture is uniformly emulsified with a homomixer. After the emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 5 Emulsion (Formulation) Microcrystalline wax 1.0% by weight Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) ) Sorbitan monooleate 1.0 Propylene glycol 7.0 Chemex acetone extract 10.0 Sodium bisulfite 0.01 Ethyl paraben 0.3 Perfume Appropriate amount Ion-exchange water Residue (Production method) Add propylene glycol to ion-exchange water ,
Heat and maintain at 70 ° C. (aqueous phase). The other components are mixed, heated and melted and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added thereto, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 6 Jelly (formulation) 95% ethyl alcohol 10.0% by weight dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer 1.0 (trade name: Carbopol) 940, BFGoodrich Chemical company) Caustic soda 0.15 L-arginine 0.1 Sunbilot 50% ethanol aqueous solution extract 7.0 Sodium 2-hydroxy-4-methoxybenzophenonesulfonate 0.05 Ethylenediaminetetraacetate trisodium 2 water 0 .05 Methylparaben 0.2 Perfume Appropriate amount Ion-exchanged water Residue (Preparation method) Carbopol 940 is uniformly dissolved in ion-exchanged water, while 50% ethanol solution of sunbilot in 95% ethanol, polyoxyethylene (50 mol)
Dissolve the oleyl alcohol ether and add to the aqueous phase. Then, after adding other components, caustic soda, L
-Neutralize with arginine to thicken.

Example 7 Essence (Formulation) (A phase) Ethyl alcohol (95%) 10.0% by weight Polyoxyethylene (20 mol) octyldodecanol 1.0 Pantothenyl ethyl ether 0.1 Chemex methanol extraction Product 1.5 Methyl paraben 0.15 (B phase) Potassium hydroxide 0.1 (C phase) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (Product name: Carbopol) 940, BFGoodrich Chemical c
ompany) Purified water residue (Preparation method) Dissolve A phase and C phase uniformly, and add A to C phase
Add phases and solubilize. Next, after adding the phase B, filling is performed.

Example 8 Pack (Formulation) (Phase A) Dipropylene glycol 5.0% by weight Polyoxyethylene (60 mol) hydrogenated castor oil 5.0 (Phase B) Sunbiloto methanol extract 0.01 Olive oil 0 Tocopherol acetate 0.2 Ethyl paraben 0.2 Fragrance 0.2 (C phase) Sodium bisulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, Polymerization degree 2,000) Ethanol 7.0 Purified water Residue ( Production method) A phase, B phase, and C phase are each dissolved uniformly,
Add phase B to phase and solubilize. Next, this is added to the C phase and then filled.

Example 9 Solid foundation (formulation) Talc 43.1% by weight Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8 2.0 Isostearic acid 4.0 POE sorbitan monooleate 3.0 Isocetyl octanoate 2.0 Chemux ethanol extract 1.0 Preservatives Appropriate amount Fragrance Appropriate amount (Production method) Powdery components of talc to black iron oxide are sufficiently mixed in a blender. Then, an oil component of squalane to isocetyl octanoate, a chemus ethanol extract, a preservative, and a fragrance are added, kneaded well, and the mixture is filled into a container and molded.

Example 10 Emulsion type foundation (cream type) (Prescription) (Powder part) Titanium dioxide 10.3% by weight Sericite 5.4 Kaolin 3.0 Yellow iron oxide 0.8 Bengala 0.3 Black iron oxide 0.2 (oil phase) Decamethylcyclopentasiloxane 11.5 Liquid paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane
0 (aqueous phase) purified water 50.0 1,3-butylene glycol 4.5 sunbilot ethanol extract 1.5 sorbitan sesquioleate 3.0 preservatives appropriate amount perfume appropriate amount (production method) The powder portion sufficiently mixed and pulverized is added and subjected to a homomixer treatment. Further, the oil phase mixed by heating is added, and the mixture is treated with a homomixer. Then, a fragrance is added with stirring, and the mixture is cooled to room temperature.

[0028]

As described above, the anti-aging agent of the present invention promotes the production of collagen, can maintain elastic, wrinkle-free or sagging skin, and prevents skin aging. It can maintain youthful skin condition.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code Agency reference number FI Technical display location A61K 7/50 A61K 7/50 35/78 ADA 35/78 ADAW AGZ AGZC

Claims (3)

[Claims] 1. An anti-aging agent comprising one or two selected from the following plant extracts. (1) Sambiroto (scientific name: Androgra
phis panicurata) (2) Kemucus (scientific name: Piper cubeba) 2. The anti-aging agent according to claim 1, which is a collagen production promoter. 3. The anti-aging agent according to claim 1, which is an anti-aging cosmetic.