JP2002275018A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation containing an active oxygen- scavenging ingredient that has higher active oxygen-scavenging effect than those of conventional active oxygen scavengers, causes no deterioration in the preparation and affords high phermacodynamic effects. SOLUTION: This skin care preparation contains (A) an Aralia cordata extract alone, and optionally (B) at least one active oxygen scavenger.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin containing an extract from a specific plant. More specifically, the present invention relates to an extract of udo, which enhances the ability of active skin to remove active oxygen in the skin. The present invention relates to an external preparation for skin having an excellent anti-aging effect on the skin, such as preventing skin aging caused by active oxygen generated in the skin.

[0002]

2. Description of the Related Art Oxygen is an essential substance for life activity, but it has been found that the production of active oxygen by using oxygen has a great effect on skin aging. Therefore, active oxygen scavengers have been added to skin external preparations for the purpose of preventing aging without accumulating oxidized substances in the skin.

[0003]

However, when a highly effective substance is incorporated into an external preparation for skin, it is necessary to consider the safety of the living body. In many cases, the desired effect cannot be obtained due to insufficient active oxygen removing effect or deterioration in the preparation in many cases, and improvement thereof has been desired.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to improve the efficacy of the medicinal component of the external preparation for skin, and as a result, the extract from a specific plant has high safety to the living body and high safety. The present inventors have found that they have an active oxygen removing effect, and have completed the present invention.

That is, the present invention relates to udo (Aralia)
The present invention provides an external preparation for skin having an excellent anti-aging effect, characterized by incorporating an extract obtained from C. cordata) as an active oxygen removing component.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The plant used in the present invention is:
The Japanese name is "Udo", also known as "Tsutitara". In Japan, it is a plant belonging to the genus Taranoki, which grows from grasslands and subalpine grasslands to subalpine mountains from Hokkaido to Kyushu. The extract used in the present invention is obtained from udo using various extraction solvents. The extraction method is not particularly limited,
Extraction is carried out at a low temperature or at room temperature or under heating using an appropriate solvent.

As the extraction solvent, for example, one or more of water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; and liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol are used. be able to. An example of a preferable extraction method is a method in which whole plants (roots, stems, leaves, and buds) obtained by drying udo are crushed, water is added, and the mixture is heated to obtain an extract.

[0008] The content of the udo extract in the external preparation for skin of the present invention is preferably 0.00005 as dry solids.
To 5% by mass (hereinafter simply referred to as "%"), more preferably 0.0005 to 1%. If the content of the udo extract is less than 0.00005%, a sufficient effect may not be obtained, and if the content exceeds 5%, no further increase in the effect is observed.

On the other hand, the active oxygen remover which is the component (B) of the present invention includes superoxide dismutase,
Mannitol, beta-carotene, astaxanthin, lutein and other carotenoids and animal and plant extracts containing them, hydroquinone and its derivatives and their salts, bilirubin, cholesterol, tryptophan, histidine, quercetin, quercitrin, catechin and its derivatives, rutin and Derivatives thereof, taurine, thiotaurine, soybean or egg-derived phospholipids, eggshell membrane extract, placenta extract, gallic acid and its derivatives, stevia,
Gravlidine, glabrene, liquiritin, isoliquiritin and liquorice extract containing them, yeast extract, seaweed extract, seaweed extract, tolmentilla extract, arhat extract, ginkgo extract, reishi extract, grape seed extract, Tea extract, such as keikei extract, green tea, black tea, oolong tea, peonies extract, gentian extract, hawthorn extract, rosemary extract, mocca extract, saxifrage extract, yasajitsu extract, gennoshoko extract, sardine extract Vitamin A, such as carotenoids such as foods, melissa extract, parsley extract, dicoppi extract, retinol and its derivatives (retinol palmitate, retinol acetate, etc.), retinal and its derivatives, dehydroretinal, carotene; thiamines (thiamine Hydrochloride, thiamine sulfate Salt), riboflavins (riboflavin, acetic riboflavin, etc.), pyridoxine compound (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.),
Vitamin B such as flavin adenine nucleotide, cyanocobalamin, folate, nicotinic acid (nicotinamide, benzyl nicotinate), choline; vitamin C and its derivatives (L-ascorbic acid, palmitic L-)
Ascorbyl, L-ascorbyl dipalmitate, L-ascorbyl isopalmitate, L-diisopalmitate
-Ascorbyl, L-ascorbyl tetraisopalmitate, L-ascorbyl stearate, L-ascorbyl distearate, L-ascorbyl isostearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl dimyristate, isomyristine L-ascorbyl acid, L-ascorbyl diisomyristate, L-ascorbyl oleate, L-ascorbyl dioleate, L-ascorbyl 2-ethylhexanoate, sodium L-ascorbate, L-ascorbate Potassium, magnesium L-ascorbate, calcium L-ascorbate,
L-ascorbic acid phosphate aluminum, L-
Sodium ascorbate sulfate, potassium L-ascorbate sulfate, magnesium L-ascorbate sulfate, calcium L-ascorbate sulfate, aluminum L-ascorbate sulfate, sodium L-ascorbate, potassium L-ascorbate, L-magnesium ascorbate, L
-Vitamin Ds such as ergocalciferol, cholecalciferol, dihydroxystanal, etc .;
Tocopherol and its derivatives (dl-α (β, γ)-
Tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α-tocopherol, linoleic acid-dl
-Α-tocopherol, dl-α-tocopherol succinate), vitamin Es such as ubiquinones, glutathione and its derivatives, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Among these active oxygen scavengers, particularly preferred are vitamin C and its derivatives, carotenoids such as superoxide dismutase, mannitol, beta-carotene and astaxanthin, rutin and its derivatives, glabridine, glabrene, liquiritin, Examples include isoliquiritin and liquorice extract, ginkgo extract, grape seed extract, calyx extract, yasadtsu extract, zikkopi extract and yeast extract containing these.

That is, the content of the active oxygen remover of the component (B) in the external preparation for skin of the present invention is preferably 0.00001 to 10%, more preferably 0.0001.
~ 5%. When the plant extract or the like is used as the extract as it is in this range as a dry solid content, when combined with the udo extract, it does not affect the preparation and the udo extract in the preparation, and the stability over time is also obtained. Good and excellent skin aging prevention effect and skin roughness improvement effect can be obtained. In other words, the production of lipid peroxide due to active oxygen production in the skin,
It is effective in preventing skin inflammation, blackening, aging and the like. These active oxygen removing agents can be used alone or in combination of two or more.

The external preparation for skin of the present invention is prepared according to a conventional method, using the essential component (A), the components (A) and (B) in various forms known as ordinary external preparations for skin. It can be prepared by mixing with a base.

Examples of the form of the external preparation for skin are not particularly limited, and include, for example, skin care cosmetics such as milky lotions, creams, lotions, packs, cleaning agents, makeup cosmetics such as lipsticks and foundations, and scalp cosmetics. , Ointments, dispersions, etc., can be used as external medicines, and there is no particular limitation on the form of the preparation, solid form, paste, mousse, gel, powder, solution, solubilization, emulsification, etc. Systems, powder dispersions, and multilayers.

In addition to the components (A) and (B), the external preparation for skin of the present invention usually contains cosmetics, quasi-drugs, and external medicines as long as the effects of the present invention are not impaired. Ingredients used in the formulation, i.e., water, oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, UV protection agents, clathrate compounds, antibacterial Agents, fragrances, deodorants, salts, pH regulators, cooling agents, animal / microbial extracts, plant extracts, blood circulation enhancers, astringents, antiseborrheic, whitening, anti-inflammatory, humectants, One or more of anti-inflammatory agents, keratolytic agents, enzymes, hormones, vitamins, and the like can be appropriately added. Specific examples of suitable components include those shown below. Here, the “derivative” includes a salt that can be formed.

[0015] The oil may be a natural oil or a synthetic oil, as long as it is used in ordinary cosmetics to improve the constituent components of the base or the usability and usability. Alternatively, irrespective of properties such as solid, semi-solid, and liquid, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine-based oils, and the like can be used. . Examples thereof include hydrocarbons such as squalane and petrolatum, oils and fats derived from plants and animals such as castor oil and mink oil, and waxes such as beeswax, carnauba wax, candelilla wax and gay wax.

The surfactant is used for emulsifying and solubilizing oils and the like, and anionic, cationic, nonionic and amphoteric surfactants can be used.

The metal soap is a metal salt other than an alkali salt such as a fatty acid, such as aluminum stearate,
Examples include magnesium stearate and zinc laurate.

The gelling agent is used for stabilizing the system, improving the usability, and improving the feeling of use. Amino acid derivatives such as N-lauroyl-L-glutamic acid; dextrin fatty acid esters such as dextrin palmitic acid ester; Examples include fatty acid esters and organically modified clay minerals.

The powder is used for various purposes such as coloring in makeup cosmetics, concealing the skin, or improving the feeling of use. If the powder is used in ordinary cosmetics, its shape (spherical, needle, etc.) is used. Shape, plate shape, etc.), particle size (fog, fine particles, pigment grade, etc.), and particle structure (porous, non-porous, etc.), any of which can be used.
For example, examples of the inorganic powder include barium sulfate, calcium carbonate, talc, mica, synthetic mica, mica, kaolin, sericite, silicic acid, silicic anhydride, aluminum magnesium silicate, ceramic powder, and boron nitride. Organic powders include polyester powder, polyethylene powder, polystyrene powder, nylon powder, lauroyl lysine, and the like.Colored pigments include inorganic pigments such as iron oxide, carbon black, chromium oxide, navy blue, ultramarine blue, and tar-based pigments. Laked pigments and laked natural pigments are listed. Pearl pigments include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scales Foil, titanium oxide-coated colored mica, etc. Other tar pigments, natural pigments such as carminic acid. Compounding these powders,
The surface treatment may be performed with an oil agent, silicone, or a fluorine compound.

Examples of alcohols include lower alcohols such as ethanol and isopropanol, glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol and the like. Can be

The water-soluble polymer is used for stabilizing the system, improving the usability and usability, and also for obtaining a moisturizing effect. Specific examples of the water-soluble polymer include plant polymers such as carrageenan, pectin, agar, and locust bean gum; microbial polymers such as xanthan gum; animal polymers such as casein and gelatin; and starch polymers such as starch. , Methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxypropylcellulose, nitrocellulose, cellulosic polymers such as crystalline cellulose, alginic acid polymers such as sodium alginate, vinyl polymers such as carboxyvinyl polymer,
Examples include polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate, and inorganic water-soluble polymers such as bentonite and hectorite. Also,
These also include film-forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone.

Antibacterial agents are used for the purpose of preventing and improving acne and the like, and include benzoic acid, sodium benzoate, paraoxybenzoate, parachloromethcresol, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol and the like. .

Moisturizers are used for moisturizing the skin to prevent aging such as wrinkles, and include proteins such as glycerin, 1,3-butylene glycol, collagen, elastin, and keratin or derivatives thereof;
Hydrolysates and salts thereof, hyaluronic acid, mucopolysaccharides such as chondroitin sulfate and derivatives thereof, histidine,
Serine, glycine, theanine, aspartic acid, amino acids such as arginine and derivatives thereof, sorbitol,
Erythritol, trehalose, inositol, glucose, xylitol, sucrose and its derivatives, dextrin and its derivatives, saccharides such as honey, D-panthenol and its derivatives, glycolipids, ceramide, amacha extract, almond extract, ashitaba extract, Avocado extract, Altea extract, Arnica extract, hot spring water, aloe extract, Usbania oyster extract, Scutellaria (Oregon) extract, Spinach extract, St. John's wort extract, Spider lily extract, Ononis extract, Chamomile extract,
Oat extract, glabridine, glabrene, liquiritin, isoliquiritin and liquorice extract, raspberry extract containing them, honeysuckle (goldenwort)
Extract, Quinseed extract, Clara (Kudin) extract, Gardenia extract, Kumazasa extract, Grapefruit extract, Watercress extract, Gentian extract, Genoshoko extract, Burdock extract, Sesame extract, Wheat extract , Comfrey (Hypericum extract), Psychic extract, Cactus extract, Saponosa extract, Salvia (Sage) extract, Hawthorn extract, Zio extract, Perilla extract, Spiraea extract, Peony extract, Ginger extract Stuff, shobu extract, birch extract, mint (peppermint) extract, mallow (U.S.), senkyu extract, mulberry (souhakuhi) extract, scotch (thyme) extract, camellia extract, Touki extract, Eucalyptus extract,
Corn extract, dokudami extract, tormentilla extract, parsley extract, mint extract, oat extract,
Hamamelis extract, rose extract, hinoki extract, sunflower extract, pyrrolidonecarboxylic acid and its salt, coltsfoot extract, Butchers bloom extract, grape extract, prune extract, loofah extract, bodaige extract, button ( (Pistil) extract, hop extract, jojoba oil, macadamia nut oil, olive oil, apricot oil, persic oil, safflower oil, sunflower oil, avocado oil, medouhome oil, camellia oil, almond oil, perilla oil, sesame oil, borage ( Borage oil), cocoa butter, shea butter, pine extract, quince extract, marronie extract, mukuroji extract, mucin, murasaki (silicon) extract, meadow home oil, melissa extract, cornflower extract, yukinoshita extract , Lily extract, Lime extract, Lavender extract, Apple extract, Li Root extract (Ryutan) extract, soybean and egg-derived phospholipids, Astragalus extract, Warmoko extract, tea extract (such as oolong tea, green tea, black tea), urea,
Arkan fruit extract, seaweed extract and the like. (In the parentheses, other names of plants, names of crude drugs, etc. are described.

The blood circulation enhancer is used for the purpose of enhancing the antiaging effect by increasing the blood flow of the skin, and includes arnica extract, pepper tincture, ginkgo extract, tocopherol acetate, γ-oryzanol and the like. Include lipase, papain and the like.

[0025]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of udo hot water extract 10 kg of whole above-ground part (stem, leaf and bud) of dried udo
Was crushed, 100 kg of water was added, extracted at 90 ° C. for 20 minutes, and squeezed with a filter cloth. The obtained squeezed liquid was concentrated, and 10 kg of udo extract clarified by centrifugation was obtained (dry solid content: 1.0%).

Reference Example 2 Production of Udoethyl Alcohol Extract 1 kg of the above-ground part (stem, leaf and bud) of dried udo was crushed, and 10 vol of 80 vol% ethyl alcohol was added.
After immersion at room temperature for 7 days, the filtrate was filtered to obtain an udo extract (dry solid content 0.9%).

Reference Example 3 Production of Orgon Extract A 10 g of Orgon (Scarabae root) was finely chopped, 100 mL of anhydrous ethyl alcohol was added, and the mixture was extracted at room temperature for 5 days with occasional stirring, and filtered to obtain an Orgon extract. (1.1% dry solids).

Reference Example 4 Production of Melissa Extract 1 kg of whole plant of Melissa was crushed, 10 L of 50 vol% ethyl alcohol was added, and the resultant was immersed at room temperature for 15 days, and the filtrate was allowed to stand in a cool dark place for 5 days, and then filtered. A Melissa extract was obtained (0.8% dry solids).

Test Example 1 Superoxide Activity Removal Measurement Test The udo extract and the active oxygen remover listed in Table 1 were used alone or in combination as a sample. After dilution with water, the superoxide removal rate was measured by the following measurement method. It was measured.

(Measurement method) A substrate solution [3.0] was added to 2.4 mL of 0.05 M sodium carbonate buffer (pH 10.2).
mM xanthine (dissolved in 0.05 M sodium carbonate buffer)] 0.1 mL, 3.0 mM EDTA 0.1
mL, 0.15% (w / v) bovine serum albumin
1 mL, 0.75 mM nitro blue tetrazolium
Mix 0.1 mL and 0.1 mL of each test sample,
For 10 minutes. Then, an enzyme solution [xanthine oxidase solution (about 0.04 units / m in purified water)
L)) to start the reaction,
After 20 minutes incubation with 6 mM CaCl ₂
The reaction is stopped by adding 0.1 mL. Then 560 nm
The absorbance (A) at is measured.

As a control, the absorbance (B) of a sample to which purified water was added instead of the test sample, and 6 blanks for each sample.
After stopping the reaction by adding 0.1 mL of mM CaCl _2, the absorbance (C) of the sample to which 0.1 mL of xanthine oxidase was added was measured, and the superoxide removal rate was calculated from the following equation (1). Table 1 shows the results.

[0033]

(Equation 1)

(Result)

[Table 1]

As is evident from the results in Table 1, the udo hot water extract alone had a high superoxide removing effect, but it has been conventionally known that it has an active oxygen removing effect. It has been shown that when used in combination with, a synergistic effect is exerted and it is extremely effective in removing active oxygen.

Example 1 Cream (Products 1 to 3 of the present invention and Comparative Products 1 to 3) Creams were prepared according to the composition shown in Table 2 and by the following production method, and the effects of beautiful skin and skin aging prevention were examined. The results are also shown in Table 2.

(Composition) and (Result)

[Table 2]

(Production method) Components (1)-(7), (11) and (12) are mixed and heated to 70 ° C. B. Mix components (8) and (13) and heat to 70 ° C
To keep. C. After B was added to A and mixed, the mixture was cooled, and (9) and (10) were added and uniformly mixed to obtain a cream.

(Test Method) 25 per test cream
A panel consisting of 15 women aged 55 to 55
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The skin and skin aging prevention effects of the application were evaluated according to the following criteria.

(Evaluation Criteria) Beautifying effect: <Evaluation> <Contents> Effective The dullness of the skin became less noticeable. Slightly effective Skin dullness became less noticeable. Ineffective No change from before use.

Anti-aging effect of skin: <Evaluation> <Contents> Effective Skin adhesion and gloss were improved. Slightly effective Skin glue, gloss slightly improved. Ineffective No change from before use.

As shown in the results of Table 2, by applying a cream containing an udo hot water extract to the skin, the occurrence of "dullness" and the like on the skin can be prevented, and the skin can be made beautiful.
It has been revealed that skin abrasion and gloss are improved and that skin aging is prevented. In addition, the creams of the present invention products 2 and 3 in which the udo hot water extract and the active oxygen remover were blended had more remarkable effects.

Example 2 Lotion: A lotion was prepared according to the following formulation and the following method. (Prescription) (%) (1) Glycerin 6.0 (2) 1,3-butylene glycol 5.5 (3) Polyoxyethylene sorbitan monolaurate 1.5 (20EO) (4) Ethyl alcohol 9 0.0 (5) Udo hot water extract * 1 10.0 (6) Mannitol * 2 0.5 (7) Preservative appropriate amount (8) Flavor appropriate amount (9) Purified water balance * 1 Produced in Reference Example 1. * 2 Sigma

(Production Method) A. Components (3), (4), (7) and (8) are mixed and dissolved. B. Components (1), (2), (5), (6) and (9) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

Example 3 Emulsion: An emulsion was prepared according to the following formulation and the following production method. (Prescription) (%) (1) Polyoxyethylene sorbitan monostearate 1.0 (10 EO) (2) Polyoxyethylene sorbitan tetraoleate 0.5 (60 EO) (3) Glyceryl monostearate Rate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Udo hot water extract * 1 3.0 (8) Astaxanthin * 2 0.02 (9 ) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Remaining purified water (14) Perfume appropriate amount * 1 In Reference Example 1 Manufactured * 2 Sigma

(Production method) Components (9) to (13) are mixed by heating and kept at 70 ° C. B. Components (1) to (6) and (8) were mixed by heating.
Keep at ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, (7) and (14) were added and uniformly mixed to obtain an emulsion.

Example 4 Ointment: An ointment was prepared according to the following formulation and the following production method. (Prescription) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Udoethyl alcohol extract * 1 2.0 (6) Licorice extract * 2 0.5 (7) Remaining purified water * 1 Produced in Reference Example 2 * 2 Maruzen Pharmaceutical Co., Ltd.

(Production method) A. A part of components (3), (4) and (7) are mixed by heating and kept at 75 ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. C was cooled and dissolved in the remainder of (7) (5),
(6) was added to obtain an ointment.

The lotion of Example 2, the lotion of Example 3, and the ointment of Example 4 are all excellent in stability over time, and when applied to the skin, the skin shine and gloss are improved, and the dullness of the skin is improved. It prevented skin aging.

Example 5 Cleaning agent: A cleaning agent was prepared according to the following formulation and the following production method. (Prescription) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl alcohol 1.5 (6) Purification Lanolin 1.0 (7) Appropriate amount of fragrance (8) Preservative 0.1 (9) Potassium hydroxide 6.0 (10) Udoethyl alcohol extract * 1 0.5 (11) Japanese pentagon extract * 2 0.5 (12) Remaining purified water * 1 manufactured in Reference Example 2 * 2 manufactured in Reference Example 3

(Production method) Heat and mix components (9) and (12) and maintain at 70 ° C. B. Components (1) to (6) and (8) were mixed by heating.
Keep at ° C. C. A was added to B and maintained at 70 ° C. for a while. After the saponification reaction was completed, the mixture was cooled to 50 ° C., and components (7), (10) and (11) were added, and the mixture was cooled to obtain a cleaning agent.

The cleaning agent of Example 5 has excellent stability over time,
When applied to the skin, it was moisturized and excellent in moisturizing properties, smoothed skin texture, applied to the skin, and given gloss.

Example 6 Pack: A pack was prepared according to the following formulation and the following method. (Prescription) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Udo hot water extract * 1 1.0 ( 6) Superoxide dismutase * 2 0.2 (7) Preservative appropriate amount (8) Fragrance 0.05 (9) Purified water Remaining * 1 Produced in Reference Example 1 * 2 Sigma

(Production method) Mixing the components (1), (3) to (6) and (9),
Heat to 70 ° C. and stir. B. Mix components (2), (7) and (8). C. B was added to A, mixed, and cooled to obtain a pack.

The pack of Example 6 has excellent stability over time,
By applying to the skin, the abrasion and luster of the skin were improved, and dullness of the skin and aging of the skin were prevented.

Example 7 Lip balm: A lip balm was prepared according to the following formulation and the following method. (Prescription) (%) (1) Microcrystalline wax 9.0 (3) Solid paraffin 8.0 (4) Vaseline 15.0 (5) Cetyl ethylhexanoate 15.0 (6) Liquid paraffin 8.0 (6) ) Castor oil remaining amount (7) Udo hot water extract * 1 0.02 (8) beta-carotene * 2 0.01 (9) BHT * 3 0.002 (10) Perfume appropriate amount * 1 Produced in Reference Example 1. * 2 Wako Pure Chemical * 3 Sigma

(Production method) A. The components (1) to (6) are heated and dissolved at 100 to 110 ° C. B. A is mixed with the components (7) to (10) at 90 ° C. C. B was cooled and molded to obtain a lip balm.

The lip cream of Example 7 was excellent in stability over time, feeling in use and finish, and was applied to the lips to keep the lips smooth and prevent roughening.

Example 8 Powder foundation: A powder foundation was prepared according to the following formulation and the following method. (Prescription) (%) (1) Mica 50.0 (2) Titanium oxide 15.0 (3) Nylon powder 5.0 (4) Remaining kaolin (5) Color pigment 3.0 (6) Paramethoxycinnamon 2-ethylhexyl acid 2.0 (7) dimethyl polysiloxane 2.0 (8) squalane 3.0 (9) glyceryl trioctanoate 2.0 (10) petrolatum 1.0 (11) udo hot water extract * 10 .02 (12) Yeast extract * 2 0.5 (13) BHA * 3 0.005 (14) Perfume appropriate amount * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Sigma

(Production method) A. Mix components (1) to (5). B. Components obtained by heating and dissolving the components (6) to (14) are added, mixed and pulverized. C. B was filled in a metal plate and press-molded to obtain a powder foundation.

The powder foundation of Example 8 is
It was excellent in stability over time, feeling in use, and finish, and was applied to skin to suppress dullness and roughness of the skin and prevent skin aging.

[0062]

As described above, udo extract is useful as a component for removing active oxygen, and it is possible to sufficiently exhibit the inherent effects of the active oxygen remover by combining it with another active oxygen remover. Can be. That is,
Production of lipid peroxide due to active oxygen production in the skin,
It has an extremely high improvement and prevention effect against inflammation, blackening, aging and the like. Therefore, the skin external preparation of the present invention,
Since the intrinsic performance of the active oxygen remover can be sufficiently exhibited, the active oxygen remover is extremely useful in beauty and medicine as having excellent antiaging and beautiful skin effects.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/48 A61K 7/48 4C206 31/045 31/045 31/05 31/05 31/07 31/07 31/122 31/122 31/185 31/185 31/353 31/353 31/355 31/355 31/375 31/375 31/404 31/404 31/4172 31/4172 31/51 31/51 31 / 56 31/56 31/593 31/593 31/7048 31/7048 35/50 35/50 35/54 35/54 35/72 35/72 35/78 35/78 MJ T Q S C A N H Z 38/00 45/00 38/44 A61P 17/16 45/00 39/06 A61P 17/16 A61K 37/02 39/06 37/50 F term (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB242 AB432 AB442 AC012 AC022 AC061 AC072 AC102 AC122 AC131 AC132 AC172 AC242 AC342 AC352 AC422 AC442 AC491 AC542 AC581 AC791 AC841 AC851 AD072 AD092 AD112 AD152 AD201 AD391 AD471 AD472 AD491 AD512 AD531 AD571 AD622 AD631 AD632 AD662 CC04 CC05 CC07 CC12 CC13 CC23 DD17 DD22 DD23 DD31 EE10 EE12 FF05 4C084 AA02 AA17 DC24 MA63 NA14 ZA891 ZC211 4C086 AA01 AA02 BA08 BA09 BA18 BC13 BC38 BC42 BC82 DA08 DA14 EA04 GA07 MA01 MA04 MA63 NA14 ZA89 ZC21 4C0A AB A88 ABA A88 AB11 AB17 AB19 AB26 AB32 AB38 AB40 AB45 AB51 AB55 AB56 AB58 AB59 AB60 AB66 AB67 BA08 CA03 MA63 NA14 ZA89 ZC21 4C206 AA01 AA02 CA05 CA10 CA13 CB21 JA08 MA01 MA04 MA83 ZA89 ZC21

Claims (4)

[Claims] 1. Udo (Aralia corddata)
An external preparation for skin, characterized by blending an extract obtained from the above as an active oxygen removing component. 2. Udo (Aralia corddata)
An external preparation for skin, characterized in that the hot water extract of (1) is blended as an active oxygen removing component. 3. An external preparation for skin, comprising the following components (A) and (B): (A) udo extract (B) active oxygen scavenger. 4. An active oxygen scavenger comprising carotenoids such as superoxide dismutase, mannitol, beta-carotene, astaxanthin, lutein and animal and plant extracts containing them, hydroquinone and its derivatives, bilirubin, cholesterol, tryptophan, histidine, quercetin , Quercitrin, catechin and its derivatives, rutin and its derivatives, taurine, thiotaurine, soybean or egg-derived phospholipids, eggshell membrane extract, placental extract, gallic acid and its derivatives, stevia,
Gravlidine, glabrene, liquiritin, isoliquiritin and liquorice extract containing them, yeast extract, pentagon extract, seaweed extract, tormentilla extract,
Arhat fruit extract, ginkgo extract, ganoderma extract, grape seed extract, cabbage extract, green tea, black tea, tea extracts such as oolong tea, peonies extract, gentian extract, hawthorn extract, rosemary extract, Mocca extract, Saxifrage extract, Yasashitsu extract, Geno ginger extract, Persimmon extract, Melissa extract, Parsley extract, Zicoppi extract, Vitamin A and their derivatives, Vitamin B and their derivatives, Vitamin C The external preparation for skin according to claim 3, wherein the external preparation is selected from the group consisting of: and its derivatives, vitamins D and their derivatives, vitamin E and its derivatives, glutathione and its derivatives, dibutylhydroxytoluene and butylhydroxyanisole.