JP2007210915A - Skin preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin preparation for external use that has excellent melanogenesis-inhibiting effect, preventing and ameliorating pigmentation such as freckles and liver spots, and ameliorating the translucent feeling of the skin, and antiaging activities with excellent cell-activating effects, and preventing and ameliorating wrinkles, flabby skin or the like. <P>SOLUTION: This skin care preparation includes a component derived from a germinated adzuki bean (Vigna angularis). Preferably, the skin care preparation comprises the component derived from a germinated adzuki bean, and one or two or more kinds of medicinal agents selected from bleaching agent, antioxidant, antiinflammatory agent, cell-activating agent and ultraviolet preventive. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a skin external preparation containing a germinated red bean-derived component, and more specifically, contains a germinated red bean-derived component as an active ingredient, has an excellent melanin production inhibitory effect, and prevents and improves pigmentation such as stains and buckwheat. In addition, it relates to a skin external preparation excellent in a whitening effect that improves the transparency of the skin, and further contains a germinated red bean-derived component as an active ingredient, and has an excellent cell activation effect to prevent and improve wrinkles, tarmi, etc. The present invention relates to an external preparation for skin having an excellent anti-aging effect.

It is known that stains, buckwheat, etc. caused by pigmentation are caused by melanin accumulation due to proliferation of melanocytes in the basal epidermis, synthesis / activation of tyrosinase, abnormal transfer of melanosomes to epidermal cells, etc. . Therefore, in order to prevent or improve stains, buckwheat and the like derived from these melanins, external preparations containing whitening agents such as ascorbic acid, glutathione and hydroquinone, that is, emulsions, creams, lotions, cosmetics, foundations and ointments. , Patches, patches and the like are used (see Non-Patent Documents 1 and 2).
In addition, retinoic acid (see Non-Patent Document 3), anti-inflammatory drug (see Non-Patent Document 4) in order to prevent or improve skin wrinkles, tarmi, elasticity and reduction in elasticity caused by exposure to ultraviolet rays, etc. Ingredients such as peanut, buckwheat extract, birch extract, sage extract, Roman chamomile extract (see Patent Document 1), Melissa extract (see Patent Document 2), and abnormal accumulation of extracellular matrix components, skin thickening, wrinkles, etc. Therefore, the formulation of active vitamin D ₃ (see Non-Patent Document 5) has been reported.

On the other hand, germinated seeds, sprouts and sprouts are vaguely defined and interpreted. First, seeds are immersed in water and then kept for 1 to 4 days in a moist environment, so that young roots germinate. This is the germinated seed. Furthermore, when this germinated seed is cultivated for several days in the absence of light, the radicle part grows and the seed part becomes digested "sprouts". Most bean sprouts are hypocotyls (roots) containing cotyledons. In addition, when sprouted seeds are further cultivated in indirect sunlight, they become “sprout”. This sprout is mostly leaves and stems. Germinated seeds, sprouts and sprouts are generally distinguished from each other by these expressions. Germinated seeds, sprouts and sprouts have been reported to undergo metabolism from starch, proteins and lipids present in the seeds and to express new active ingredients (see Non-Patent Documents 6, 7 and 8).

JP 09-268194 A Japanese Patent Application Laid-Open No. 08-109122 “Fragrance Journal”, Fragrance Journal, September 2000 issue 9-97 “Usefulness of Cosmetics”, Yakuji Nipposha, September 2000 144-161 Lorraine H. Kligman, “Effects of all-trans-retinoic acid on the dermis of hairless rice,” Journal of the American Academy of Dermatology, 1988. 15, no. 4, Part. 2, October, P.M. 779-785 Bissett DL, et al. Author, “Photoprotective effect of topical anti-inflammatory agents against ultraradiation radiation-induced chronic skin damage in the hair 90.” 7, p. 153-158 Koshiishi I, et al. “1,25-dihydroxyvitamin D3 presents the conversion of adipose tissue into fibrosstic in inspired to chronic UV iradiation.”, Toyco. 173, P.I. 99-104 Reena Randhir et al., “Phenolics, the Antioxidant and antibiological activity in dark germinated frenetic sprout in response to physic. J Clin. Nutr. 2004, vol. 13, no. 3, P.I. 295-307 Lsabella Calzuola et al., “Synthesis of antioxidants in wheat spouts”, J. Am. Agric. Food Chem. 2004, Vol. 52, p. 5201-5201 Theresa A. Shapiro et al., “Chemoprotective Glucosinolates and Isolations of Brocoli sprouts”, Cancer Epidemiol Biomarkers Prev. 2001, Vol. 10, P.I. 501-508

Conventionally, for the purpose of suppressing melanin production and whitening, medicinal ingredients such as ascorbic acid, glutathione, hydroquinone, etc. have been formulated in external preparations for skin, but it is still difficult to obtain sufficient effects on the skin, or in preparations In some cases, the desired efficacy could not be obtained due to alteration. For example, a topical skin preparation formulated with retinoic acid as a cell activator has the effect of improving the wrinkle by proliferating collagen in the upper layer of the dermis, but the effect of suppressing the generation of wrinkles is not observed, and if application is stopped There is a problem such as returning to the original. In addition, active vitamin D ₃ has a problem of side effects in calcium metabolism and the like, and it has been desired to develop a skin external preparation that is safe and sufficiently exhibits a cell activation effect. In addition, in the topical skin preparations containing UV absorbers, UV scattering agents, anti-inflammatory agents, plant extracts, etc., to suppress or improve wrinkle formation, skin thickening, etc. When these additives are blended at a high concentration, there are cases in which the feeling of use of the preparation is impaired, or the quality deteriorates at high temperatures or over time.

  In view of the above, as a result of intensive studies on components that can be used in a skin external preparation, the present inventors have found that germinated red bean-derived components obtained from germinated red bean seeds (germinated red beans) obtained by germinating red beans are: It has been found that it has a high melanin production inhibitory action and is a whitening ingredient, and also has a high cell activation action and is an excellent prevention and improvement ingredient such as wrinkles and tarmi. And, the skin external preparation containing this germinated red bean-derived component as an active ingredient has been found to have a high whitening effect and a cell activation effect, and is further superior as a skin external preparation by combining with other medicinal ingredients. The present invention was completed.

  That is, the present invention relates to a skin external preparation containing a germinated red bean-derived component, and more specifically, by containing a germinated red bean-derived component, it has an excellent melanin production inhibitory effect, and prevents pigmentation such as stains and buckwheat. The present invention relates to a skin external preparation excellent in whitening effect that improves and improves skin transparency, and also relates to a skin external preparation excellent in cell aging effect and excellent in anti-aging effect that prevents and improves wrinkles, tarmi, etc. It is also a thing. Furthermore, the present invention is a combination of one or more medicinal ingredients selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, and an ultraviolet inhibitor, and the effect of each medicinal ingredient. It is intended to provide an external preparation for skin that has an enhanced effect of whitening and anti-aging.

  Since the external preparation for skin containing the germinated red bean-derived component of the present invention has a melanin production inhibitory action, it has a high inhibitory effect on pigmentation, so that the skin becomes darkened due to sunburn or the like, spots, buckwheat, transparent skin Effective in preventing and improving whitening effects such as feeling. In addition, since it has a high cell activation effect, it is effective for anti-aging effects such as prevention and improvement of wrinkles and tarmi.

Further, the external preparation for skin of the present invention, which uses a germinated red bean-derived component in combination with one or more medicinal components selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator and an ultraviolet light inhibitor, Compared to the case where the red bean-derived component is blended alone, it has a whitening effect and an anti-aging effect which are superior.
Therefore, the external preparation for skin of the present invention can be advantageously used as a cosmetic or pharmaceutical product for the purpose of whitening and anti-aging.

Hereinafter, the present invention will be described in detail.
The method for preparing the germinated red bean-derived component used in the present invention is not particularly limited, and the germinated seeds of the red beans may be used as they are, or dried and pulverized, or may be used as a solvent. What was extracted by etc. can also be used.

  For example, seeds of legumes (Vigna angularis) belonging to legumes are immersed in water at 15 ° C. to 25 ° C. and germinated in non-light for 2 to 5 days. This is pulverized after drying. Then, it is pulverized, sterilized and sieved to obtain a powder. Although this powder can be used as it is, an extract can also be obtained and used by extracting this powder with a solvent or the like. The germinated red bean extract (hereinafter, simply referred to as “germinated red bean extract”) may be further subjected to steps such as decolorization and deodorization as necessary, and further the solvent is distilled off to solidify / powder. (Hereinafter, simply referred to as “germinated red bean extract”).

  Examples of the extraction solvent include water, lower monohydric alcohols (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (glycerin, propylene glycol, 1, 3 -Butylene glycol etc.), lower esters (ethyl acetate etc.), hydrocarbons (benzene, hexane, pentane etc.), ketones (acetone, methyl ethyl ketone etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether etc.), acetonitrile etc. 1 type or 2 types or more can be used.

  As an example of a preferable extraction method, water-containing ethyl alcohol or water-containing 1,3-butylene glycol having a concentration of 0 to 100 vol% is used, and after extraction for 1 to 10 days at room temperature or after heating, it is obtained by filtration. A method of further purifying the filtrate by column fractionation, molecular weight fractionation or the like with a hydrophobic resin, an ion exchange resin or the like can be mentioned.

  The content of the germinated red bean-derived component used in the present invention in the external preparation for skin is preferably 0.00001 to 5% by mass (hereinafter simply referred to as “%”) as the dry solid content, and more preferably 0.0001 to 2%. Within this range, the germinated red bean-derived component can be blended stably and high medicinal effects can be exhibited. In addition, when the extract is used, the concentration of the extract is not limited as long as the content of the dry solid as a solute is within the above range.

  The germinated red bean-derived component used in the present invention is formulated as a melanin production-suppressing component or a cell activation component by blending it with various forms of bases used in normal skin external preparations in accordance with conventional methods. Although an external preparation for skin can be obtained, an external preparation for skin with a synergistic increase in these effects can be obtained by further combining with other medicinal ingredients.

In the present invention, the medicinal component used in combination with the germinated red bean-derived component is selected from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, and an ultraviolet ray inhibitor. For example, the following are mentioned. Here, “derivatives” include esters and salts that can be formed.
(The parentheses in the plant name also indicate the plant alias, the name of the herbal medicine, etc.)

(Whitening agent)
As a whitening agent, vitamin C and its derivatives (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate, L-ascorbic acid sulfate, etc.) , Grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, yokoinin extract, oak extract, seaweed extract (comb, macombu, wakame, hijiki, hibamata, sujime, trorocomb, cajime Brown algae such as swordfish, vineyard, chigaiso, hondawala, giant kelp; Green algae such as La, Aonori, Donariella, Chlorococcus, Anaaaosa, Kawanori, Marimo, Shiogusa, Casanori, Futojuzumo, Tamajuzumo, Aegusa, Aomidoro etc .; Cyanobacteria such as Spirulina, etc. Tomato extract, carotenoids (carotene, lycopene, astaxanthin, etc.), agarose, oligosaccharides, hydroquinone and derivatives thereof, cysteine and derivatives thereof, Ibukitorano extract, Neubara extract, sorghum extract, pea extract, Chamomile extract, caquette extract, orange extract, raspberry extract, kiwi extract, Clara extract, coffee extract, sesame oil, sesame oil, sesame extract, rice extract, rice extract, Saisin extract , Hawthorn extract, sunpens extract, peony extract, shirayuri extract, mulberry extract, toki extract, beech extract, beech bud extract, black currant extract, hop extract, Maika (Maikai, Hermanus) extract, Mokka (bokeh) extract, Yukinosita extract, tea extract (Oolong tea, black tea, green tea, etc.), ganoderma extract, microbial fermentation metabolite, soybean extract, molasses extract, Rakan fruit extract etc. are mentioned. These whitening agents can be used alone or in combination of two or more.

  Among these whitening agents, particularly preferred are vitamin C and its derivatives, licorice extract, yakuinin (barley) extract, wheat extract, seaweed extract, and tea extract.

(Antioxidant)
Antioxidants include butylhydroxyanisole (BHA), dibutylhydroxytoluene (BHT), vitamin E and its derivatives (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl. -Α-tocopherol, linoleic acid-dl-α-tocopherol, tocopherols and derivatives thereof such as dl-α-tocopherol succinate, ubiquinones and the like, vitamin A and derivatives thereof (retinol palmitate, retinol acetate, etc., and their Derivatives, retinals such as dehydroretinal, and derivatives thereof), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin B and derivatives thereof (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxyl hydrochloride) Dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), vitamin C and its derivatives (dipalmitate L-ascorbyl, tetraisopalmitate L-ascorbyl, etc.) L-ascorbic acid alkyl ester, L-ascorbic acid phosphoric acid ester, L-ascorbic acid sulfuric acid ester, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal etc.), rutin and its derivatives, Thiotaurine, taurine, hydroquinone and derivatives thereof, histidine, catechin and derivatives thereof, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, glutathione And derivatives thereof, gallic acid and derivatives thereof, cholesterol and derivatives thereof, superoxide dismutase, mannitol, cucumber extract, quette extract, gentian (gentian) extract, genocarpus extract, hawthorn extract, peonies extract, ginkgo biloba extract , Koganebana (Ougon) extract, carrot extract, maikaika (maikai, hamanasu) extract, sunpens (kawaraketsumei) extract, tormentilla extract, parsley extract, grape extract, button (button pi) extract, mokka ( Bokeh) extract, Melissa extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannenrou) extract, lettuce extract, tea extract (Oolong tea, black tea, green tea, etc.), microbial fermentation metabolites, seaweed Extract, Ganoderma extract, eggshell A membrane extract, a placenta extract, a rahan fruit extract, etc. are mentioned. These antioxidants can be used alone or in combination of two or more.

  Among these antioxidants, particularly preferred are butylhydroxyanisole (BHA), dibutylhydroxytoluene (BHT), vitamin E and its derivatives, vitamin C and its derivatives, rutin and its derivatives, yashajitsu extract, yukinoshita Examples include extracts, micaika extract, superoxide dismutase, ginkgo biloba extract, glutathione and its derivatives, histidine, mannitol, and carotenoid.

(Anti-inflammatory agent)
Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide , Cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), aloe extract, ashitaba extract, altea extract, arnica extract, sulfur and its derivatives, nettle extract Kawamomogi) extract, Turmeric extract, Yellowfin extract, Hypericum extract, Chamomile extract, Comfrey extract, Honeysuckle extract, Watercress extract, Salvia (sage) extract, Lemoko extract, perilla extract, birch extract, elder extract, larva extract, mugwort extract, eucalyptus extract, mugwort extract, forsythia extract, chondroitin sulfate and its derivatives, zinc oxide Etc. These anti-inflammatory agents can be used alone or in combination of two or more.

  Among these anti-inflammatory agents, particularly preferred are glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives, perilla extract, bitumen extract, comfrey extract Is mentioned.

(Cell activator)
Examples of cell activators include carotenoids (such as carotene, lycopene, astaxanthin), vitamin A and derivatives thereof (retinol such as retinol palmitate and retinol acetate; and retinals such as dehydroretinal and derivatives thereof), vitamin C and its derivatives. Derivatives (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate and L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate, L-ascorbic acid sulfate, etc.), vitamin B and its derivatives (thiamine hydrochloride) Salt, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinamide and benzyl nicotinate (Tinic acids, choline, etc.), ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, α- and γ-linolenic acid, xanthine and derivatives thereof (caffeine, etc.), amino acids and derivatives thereof (serine, glutamic acid, theanine, hydroxy) Proline, pyrrolidone carboxylic acid, etc.), docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, citric acid, lactic acid, malic acid, succinic acid, almond extract, apricot extract, ginkgo biloba extract, yellowfin ) Extract, Barley (Bakuga) extract, Kiwi extract, Cucumber extract, Shiitake extract, Japanese horse chestnut extract, Assembly extract, Soybean extract, Jujube extract, Rhizoma extract, Pepper extract, Tokachinka extract, tomato extract, garlic extract, garlic Extract, Bukuryu extract, Grape seed oil, Beech extract, Beech sprout extract, Peach extract, Eucalyptus extract, Lily extract, Lettuce extract, Lemon extract, Rosemary extract, Malt Root extract, animal-derived extract (mollusk and other mollusc extracts, shell extract, shellfish extract, fish extract, chicken crown extract, royal jelly, silk protein and its degradation products, placenta extract, serum deproteinization extraction Product, lactoferrin or its degradation product), yeast extract, microbial fermentation metabolite (derived from lactic acid bacteria, bifidobacteria, etc.), ganoderma extract and the like. These cell activators can be used alone or in combination of two or more.

  Among these cell activators, particularly preferred are vitamin A and its derivatives, vitamin C and its derivatives, vitamin B and its derivatives, yeast extract, microbial fermentation metabolites (derived from lactic acid bacteria, bifidobacteria, etc.), spirits Examples include turf extract, carrot extract, malt root extract, soybean extract, camellia extract, and beech bud extract.

(UV protection agent)
Examples of UV inhibitors include paramethoxycinnamate-2-ethylhexyl, 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone and derivatives thereof (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.), titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide and the like. These ultraviolet inhibitors can be used alone or in combination of two or more.

  Among these UV inhibitors, particularly preferred are 2-methoxyhexyl paramethoxycinnamate, 4-tert-butyl-4′-methoxydibenzoylmethane, titanium oxide, fine particle titanium oxide, zinc oxide and Fine zinc oxide is exemplified.

  Although content of the said medicinal component in the skin external preparation of this invention changes with kinds of medicinal component, it is preferable to set it as the range shown below. Within this range, when combined with germinated red bean-derived ingredients, the whitening effect of preventing and improving higher pigmentation by suppressing melanin production and improving skin transparency without affecting the temporal stability of the preparation. In addition, an excellent anti-aging effect can be exhibited by a cell activation effect that prevents and improves wrinkles and tarmi.

  That is, the content of the whitening agent in the external preparation for skin of the present invention is preferably 0.00001 to 10%, more preferably 0.0001 to 5%. When the extract is used as an extract, it may be in this range as a dry solid content. If it is this range, the skin external preparation with the whitening effect and anti-aging effect which improved more synergistically will be obtained.

  The content of the antioxidant in the external preparation for skin of the present invention is preferably in the range of 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as an extract, it may be in this range as a dry solid content. If it is in this range, it shows an excellent antioxidant effect, and further shows an improved melanin production inhibitory effect, a cell activation effect, prevention and improvement of pigmentation such as stains, buckwheat, etc., and whitening effect such as skin transparency, A skin external preparation having an anti-aging effect such as prevention and improvement of wrinkles, tarmi and the like can be obtained.

  The content of the anti-inflammatory agent in the external preparation for skin of the present invention is preferably in the range of 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as an extract, it may be in this range as a dry solid content. If it is in this range, it exhibits an excellent anti-inflammatory effect, and further shows an improved melanin production inhibitory effect, a cell activation effect, prevention and improvement of pigmentation such as spots and freckles, and a whitening effect such as skin transparency, A skin external preparation having an anti-aging effect such as prevention and improvement of wrinkles, tarmi and the like can be obtained.

  The content of the cell activator in the external preparation for skin of the present invention is preferably 0.00001 to 5%, more preferably 0.0001 to 3%. When the extract is used as an extract, it may be in this range as the dry solid content. If it is in this range, it shows an excellent skin roughness improvement effect, and further shows an improved melanin production inhibitory effect, cell activation effect, prevention and improvement of pigmentation such as stains, buckwheat, etc., and whitening effect such as skin transparency, A skin external preparation having an anti-aging effect such as prevention and improvement of wrinkles, tarmi and the like can be obtained.

  The content of the ultraviolet ray inhibitor in the external preparation for skin of the present invention is preferably 0.01 to 25%, more preferably 0.1 to 10%. If it is in this range, it shows an excellent ultraviolet ray prevention effect, and further shows an improved melanin production inhibitory effect, a cell activation effect, prevention and improvement of pigmentation such as stains, buckwheat, etc., and whitening effect such as skin transparency, A skin external preparation having an anti-aging effect such as prevention and improvement of wrinkles, tarmi and the like can be obtained.

  These whitening agents, antioxidants, anti-inflammatory agents, cell activators and ultraviolet light inhibitors can be used singly or in combination of two or more.

  The skin external preparation of the present invention is prepared by blending (A) component, which is an essential component, or (A) component and (B) component in various forms of bases known as normal skin external preparations according to a conventional method. Can be prepared.

  Examples of the formulation of the external preparation for skin are not particularly limited, and examples thereof include emulsions, creams, lotions, cosmetics, packs, cleaning agents, makeup cosmetics, dispersions, ointments, solutions, aerosols, patches, and the like. Any form of cosmetic may be used, such as an external medicine.

  Further, in the external preparation for skin of the present invention, components that are usually used in preparations such as cosmetics, quasi-drugs, external medicines, etc., as long as they do not impair the effects of the present invention, if necessary, water ( Purified water, hot spring water, deep water, etc.), oil agent, surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, clathrate compound, antibacterial agent, fragrance, Deodorant, salt, pH adjuster, freshener, plant / animal / microbe-derived extract, blood circulation promoter, astringent, antiseborrheic agent, moisturizer, chelating agent, keratolytic agent, enzyme, hormones, Vitamins can be added. Specific examples of suitable components include those shown below. Here, “derivatives” include salts that can be formed.

As an oil agent, it is a natural oil, a synthetic oil, or a solid oil as long as it is used for normal cosmetics as a constituent component or usability of the base, improving the feeling of use. Regardless of properties such as semi-solid or liquid, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine oils and the like can be used.
For example, hydrocarbons such as squalane, petrolatum, olive oil, castor oil, jojoba oil, mink oil, macadamia nut oil, apricot oil, persic oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, Examples include oils and fats derived from plants and animals such as almond oil, sesame oil, sesame oil, borage oil, cocoa butter, and shea butter, waxes such as beeswax, carnauba wax, candelilla wax, and gay wax.

  Surfactants are used for emulsification and solubilization of oils and the like, and anionic, cationic, nonionic and amphoteric active agents can be used.

  The metal soap is a metal salt other than an alkali salt such as a fatty acid, and examples thereof include aluminum stearate, magnesium stearate, and zinc laurate.

  Gelling agents are used to improve the stability and usability of the system, and the feeling of use. Amino acid derivatives such as N-lauroyl-L-glutamic acid, dextrin fatty acid esters such as dextrin palmitate, sucrose fatty acid esters, Examples include organically modified clay minerals.

  The powders are mainly used for multi-purpose purposes such as coloring in makeup cosmetics, skin hiding, or to improve the feeling of use. If they are used in ordinary cosmetics, their shapes (spherical, needle-like, Regardless of plate shape, etc.), particle size (fog, fine particles, pigment grade, etc.) and particle structure (porous, nonporous, etc.), any of them can be used. For example, as the inorganic powder, barium sulfate, calcium carbonate, talc, mica, synthetic mica, mica, kaolin, sericite, silicic acid, anhydrous silicic acid, magnesium aluminum silicate, ceramic powder, boron nitride and the like can be mentioned, Examples of organic powders include polyester powder, polyethylene powder, polystyrene powder, nylon powder, lauroyl lysine, and colored pigments include inorganic pigments such as iron oxide, carbon black, chromium oxide, bitumen, and ultramarine blue, and tar-based pigments. Examples include pearl pigments and natural pigment lakes. Pearl pigments include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scales. Foil, titanium oxide-coated colored mica, etc. Other tar pigments, natural pigments such as carminic acid. These powders may be combined, or surface treatment may be performed with an oil agent, silicone, or fluorine compound.

  Examples of alcohols include lower alcohols such as ethanol and isopropanol, glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol.

  Water-soluble polymers are used to improve the stability, usability, and feeling of use of the system, and also to obtain a moisturizing effect. Specific examples of water-soluble polymers include plant polymers such as carrageenan, pectin, agar, locust bean gum, microbial polymers such as xanthan gum, animal polymers such as gelatin, starch polymers such as starch, and methylcellulose. Cellulose polymers such as carboxymethyl cellulose, hydroxypropyl cellulose, crystalline cellulose, alginic acid polymers such as sodium alginate, polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer polymers, carboxyvinyl polymers, poly Examples thereof include acrylic polymers such as sodium acrylate, inorganic swelling components such as bentonite and hectorite, and film-forming water-soluble polymers such as polyvinyl alcohol and polyvinyl pyrrolidone.

  Examples of humectants include proteins such as glycerin, 1,3-butylene glycol, collagen, elastin, and keratin, derivatives thereof, hydrolysates thereof, salts thereof, mucopolysaccharides such as hyaluronic acid, chondroitin sulfate, and derivatives thereof, and their Amino acids such as salts, histidine, serine, glycine, theanine, aspartic acid, arginine and their derivatives and their salts, sorbitol, erythritol, trehalose, inositol, glucose, xylitol, sucrose and their derivatives, dextrin and their derivatives, honey, etc. Sugar, D-panthenol and its derivatives, glycolipid, ceramide, achacha extract, almond extract, ashitaba extract, avocado extract, altea extract, arnica extract, hot spring water, aloe extract, cormorant Veneer extract, Ogon extract, Oren extract, Hypericum extract, Odori extract, Ononis extract, Chamomile extract, Oat extract, Licorice extract, Raspberry extract, Ginkgo extract, Quince seed extract, Kujin Extract, Gardenia extract, Kumazasa extract, Grapefruit extract, Watercress extract, Gentiana extract, Gentian extract, Burdock extract, Sesame extract, Wheat extract, Comfrey extract, Saisin extract, Cactus extract , Savanna extract, salvia extract, hawthorn extract, sage extract, perilla extract, shimotake extract, peony extract, ginger extract, ginger extract, birch extract, mint extract, mallow extract , Senkyu extract, sokuhakuhi extract, ta Musk extract, camellia extract, toki extract, eucommia extract, corn extract, dokudami extract, tormentilla extract, parsley extract, peppermint extract, barley extract, clam extract, rose extract, cypress extract Product, sunflower extract, pyrrolidone carboxylic acid and its salt, dandelion extract, butcher's bloom extract, grape extract, pruned extract, loofah extract, bodaiju extract, button extract, hop extract, pine extract, Quince extract, Marronnier extract, Mukuroji extract, Mucin, Murasaki extract, Melissa extract, Cornflower extract, Yukinoshita extract, Lily extract, Lime extract, Lavender extract, Apple extract, Gentian extract, Soybean and egg-derived phospholipids, Astragalus extract, oolong tea, Examples include tea extracts such as green tea and black tea, urea, rahan fruit extract, seaweed extract and the like. By blending these humectants, the effect of the present invention can be enhanced.

  Examples of the antibacterial agent and fungicide include benzoic acid, sodium benzoate, paraoxybenzoic acid ester, parachlorometacresol, benzalkonium chloride, phenoxyethanol, isopropylmethylphenol, hinokitiol and the like.

  Examples of the blood circulation promoter include arnica extract, red pepper tincture, ginkgo biloba extract, tocopherol acetate, γ-oryzanol and the like, and examples of the enzyme include lipase and papain.

  Next, although a manufacture example, a test example, and an Example are given and this invention is demonstrated in detail, this invention is not restrict | limited at all by these.

Production Example 1 A red bean (Vigna angularis) seed was immersed in water at 15 ° C. to 25 ° C., germinated in non-light for 2 to 5 days, and dried to obtain a dried germinated red bean. The germinated red beans thus obtained were pulverized, 1,000 mL of water was added to 100 g of the pulverized product, and hot water extraction was performed for 1 hour. After cooling, it was filtered under pressure to obtain 780 mL of an extract, which was concentrated under reduced pressure using an evaporator. This solution was freeze-dried to obtain 8.5 g as a solid (germinated red bean extract).

  Production Example 2 To 100 g of the germinated red bean pulverized product obtained in Production Example 1, 1,000 mL of 50 vol% hydrous ethyl alcohol was added, and reflux extraction was performed for 1 hour. After extraction, the mixture was filtered under pressure to obtain 750 mL of an extract and concentrated under reduced pressure using an evaporator. This solution was freeze-dried to obtain 7.6 g as a solid (germinated red bean extract).

  Production Example 3 To 100 g of the red bean pulverized product obtained in Production Example 1, 1,000 mL of 50 vol% hydrous ethyl alcohol was added, and reflux extraction was performed for 1 hour. After extraction, the mixture was filtered under pressure to obtain 740 mL of an extract, and concentrated under reduced pressure using an evaporator. This solution was lyophilized to obtain 7.8 g as a solid.

Production Example 4 Production of Yokuinin Extract To 100 g of Yokuinin (JP), 1000 mL of 70 vol% hydrous ethyl alcohol was added, and extraction was performed at room temperature for 3 days. After extraction, the mixture was filtered under pressure to obtain 750 mL of the extract, and concentrated under reduced pressure using an evaporator to obtain 7.6 g as a solid.

Production Example 5 Production of soybean extract To 100 g of soybean seeds, 1000 mL of 70 vol% hydrous ethyl alcohol was added, and extraction was performed at room temperature for 3 days. After extraction, the mixture was filtered under pressure to obtain 730 mL of an extract, and concentrated under reduced pressure using an evaporator to obtain 4.7 g as a solid.
After filtration, a soybean extract was obtained.

Test Example 1 Inhibition of melanin production by cell culture and cell viability test B16 melanoma cultured cells derived from mice were used. An appropriate amount of 10% FBS-containing MEM medium was taken in two 6-well plates, seeded with B16 melanoma cells, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. On the next day, the sample preparation solution was added to and mixed with the germinated red bean extract obtained in Production Examples 1 and 2 so that the final concentrations were 0 (control), 30, 100, 300, and 1000 μg / mL. On day 5 of the culture, the medium was changed, and the sample preparation solution was added again. On the next day, the medium was removed and the cells were collected after washing with phosphate buffer on one plate, and the degree of whiteness of the cultured B16 melanoma cells was evaluated according to the following criteria.
Further, as a comparative example, a similar test was conducted on a yokoinin extract (Production Example 4) that is already known to have an inhibitory action on melanin production and a simple red bean extract that was not germinated (Production Example 3).

(Criteria)
2+: Remarkably white relative to the control.
+: White relative to the control.
±: Slightly white with respect to the control −: Same black as the control

  The remaining one plate was stained with formalin-fixed cells after adding 1% crystal violet solution. The cell viability for each sample concentration was measured with a monocerator (Olympus). The results are shown in Table 1.

(result)

  As is apparent from the results in Table 1, the germinated red bean extract was found to have a high melanin production inhibitory effect and low toxicity to cultured B16 melanoma cells. On the other hand, in a simple red bean extract (Production Example 3) and a Yokuinin extract (Production Example 4), which is already known to have an inhibitory effect on melanin production, no obvious melanin production effect is observed at low concentrations such as the test concentration. It was.

Test Example 2 Cell Activation Test by Cell Culture Human neonate-derived fibroblasts NB1RGB were used. An appropriate amount of medium was taken in a 24-well plate, seeded with fibroblasts NB1RGB, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. On the next day, the sample preparation solution was added to and mixed with the germinated red bean extract obtained in Production Examples 1 and 2 so that the final concentrations were 0 (control), 10, 100, and 1000 μg / mL. On day 4 of the culture, the medium was changed, and the sample preparation solution was added again. On the next day, the medium was removed, the cells were washed with a phosphate buffer and then collected, and the number of fibroblasts NB1RGB grown in each specimen preparation solution was evaluated as the cell growth rate compared to the control.
Moreover, the same test was done also about the soybean extract (manufacture example 5) already known to have a cell activation effect | action as a comparative example and a red bean extract (manufacture example 3).

(Evaluation criteria)
The number of cells grown by adding each sample preparation solution was compared with the number of control cells, and the cell activation effect was evaluated using the cell proliferation rate as an index. The number of cells was counted using a hemocytometer. These results are shown in Table 2.

(result)

  As apparent from the results in Table 2, the germinated red bean extract (Production Examples 1 and 2) of the present invention is compared with a simple red bean extract (Production Example 3) and a soybean extract with known cell activation effect (Production Example 5). ) Was found to have a high cell activation ability in human neonatal fibroblast NB1RGB.

Example 1 Cream:
A cream was prepared by the composition shown in Table 3 and the following production method, and whitening when a germinated red bean extract (Production Example 2) was used in combination with a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator and an ultraviolet light inhibitor ( The effect of spot improvement) was examined. The results are also shown in Table 3.

(Composition and results)

(Manufacturing method)
A. Ingredients (1)-(6), (13) and (14) are mixed and heated to keep at 70 ° C.
B. Ingredient (16) is heated and maintained at 70 ° C.
C. B was added to A, (7) to (12) and (15) were mixed, and then cooled to obtain a cream.

(Test method)
A panel of 15 females aged 26 to 56 years old per test cream, and an appropriate amount of the test cream was applied to the face after washing for 12 weeks, twice daily in the morning and night. The stain improvement effect by application was evaluated according to the following criteria.

(Evaluation criteria)
<Evaluation><Contents>
Effective: Skin spots are not noticeable.
Slightly effective: Skin spots are less noticeable.
Invalid: No change before use.

  As shown in the results of Table 3, the cream of the product 1 of the present invention containing 50 vol% hydrous ethyl alcohol extract of germinated red beans (Production Example 2) contains the germinated red bean extract by applying these to the skin. Compared to Comparative Example 1 and Comparative Examples 2 to 7 in which other whitening agents, antioxidants, anti-inflammatory agents, cell activators, and UV inhibitors are blended independently, it is clear that the occurrence of stains and the like is prevented and improved. It is. Furthermore, when the germinated red bean extract (Production Example 2) and products 2-7 of the present invention containing a combination of a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator and an ultraviolet light inhibitor are applied to the skin, the germinated red beans It has been clarified that the present invention product 1 containing the extract (Production Example 2) alone has a synergistic effect of improving stains and the like, which is superior to the case of applying the product 1 of the present invention.

Example 2 Cream:
Preparation of cream with the composition shown in Table 4 and the following production method, and improvement of wrinkles when germinated red bean extract (Production Example 2), whitening agent, antioxidant, anti-inflammatory agent, cell activator and ultraviolet light inhibitor are used in combination The effect was investigated. The results are also shown in Table 4.

(Composition and results)

(Manufacturing method)
A. Ingredients (1)-(6), (12) and (13) are mixed and heated to keep at 70 ° C.
B. Ingredient (15) is heated and maintained at 70 ° C.
C. B was added to A, (7) to (11) and (14) were added and mixed, and then cooled to obtain a cream.

(Test method)
A panel of 15 women aged 27 to 54 years per test cream, and an appropriate amount of the test cream was applied to the face after washing the face twice a morning and night for 12 weeks. The wrinkle improvement effect by application was evaluated according to the following criteria.

(Evaluation criteria)
<Evaluation><Contents>
Effective: Skin wrinkles are not noticeable.
Slightly effective: Skin wrinkles are less noticeable.
Invalid: No change before use.

  As shown in the results of Table 4, the cream of the product 1 of the present invention containing 50 vol% hydrous ethyl alcohol extract of germinated red beans (Production Example 2) contains the germinated red bean extract by applying these to the skin. Compared to Comparative Example 1 and Comparative Examples 7 to 11 in which other antioxidants, anti-inflammatory agents, cell activators, and UV inhibitors are blended alone, wrinkles can be prevented and improved, and beautiful skin is obtained. Is clear. Furthermore, by applying to the skin germinated red bean extract (Production Example 2), and products 7 to 11 of the present invention containing a combination of an antioxidant, an anti-inflammatory agent, a cell activator and an ultraviolet light inhibitor. It has been clarified that the present invention product 1 in which the red bean extract (Manufacturing Example 2) is blended alone is applied to synergistically exhibit the effect of preventing and improving wrinkles that are more excellent.

Example 3 lotion (ingredient) (%)
(1) Glycerin 10.0
(2) 1,3-butylene glycol 6.0
(3) Germinated red bean extract (Production Example 1) 1.0
(4) Citric acid 0.1
(5) Sodium citrate 0.3
(6) Purified water Remaining amount (7) Polyoxyethylene (60E.O.)
Hardened castor oil 0.5
(8) Ethyl alcohol 8.0
(9) Preservative appropriate amount (10) Perfume appropriate amount

(Manufacturing method)
A. Components (1) to (6) are mixed and dissolved.
B. Components (7) to (10) are mixed and dissolved.
C. A lotion was obtained by uniformly mixing A and B.

Example 4 Lotion (Ingredient) (%)
(1) Glycerin 10.0
(2) 1,3-butylene glycol 6.0
(3) Germinated red bean extract (Production Example 1) 0.5
(4) Ginkgo biloba extract * 1 0.1
(5) Citric acid 0.1
(6) Sodium citrate 0.3
(7) Purified water remaining amount (8) Polyoxyethylene (60E.O.)
Hardened castor oil 0.5
(9) Ethyl alcohol 8.0
(10) Preservative appropriate amount (11) Fragrance 0.1
* 1 Made by Tokiwa Plant Chemistry Laboratory

(Manufacturing method)
A. Components (1) to (7) are mixed and dissolved.
B. Components (8) to (11) are mixed and dissolved.
C. A and B were mixed and uniformed to obtain a skin lotion.

Example 5 Latex (component) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene sorbitan monooleate (20E.O.) 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Methylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Nicotinic acid dl-α-tocopherol * 1 0.05
(12) Preservative appropriate amount (13) Carboxyvinyl polymer aqueous solution (1%) 10.0
(14) Sodium hydroxide 0.05
(15) Glycerin 5.0
(16) 1,3-butylene glycol 7.0
(17) Purified water remaining amount (18) ethyl alcohol 5.0
(19) Germinated red bean extract (Production Example 2) 0.1
(20) L-hydroxyproline * 2 0.2
(21) Hemp cellulose powder 3.0
(22) Fragrance appropriate amount * 1 Eisai * 2 Kyowa Hakko

(Manufacturing method)
A. Ingredients (13) to (17) are heated and mixed and maintained at 70 ° C.
B. Ingredients (1) to (12) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling C, components (18) to (22) were added and mixed uniformly to obtain an emulsion.

Example 6 Latex (component) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene sorbitan monooleate (20.E.O.) 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Methylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Astaxanthin * 1 0.2
(12) Preservative appropriate amount (13) Carboxyvinyl polymer aqueous solution (1%) 10.0
(14) Sodium hydroxide 0.05
(15) Glycerin 5.0
(16) 1,3-butylene glycol 7.0
(17) Purified water remaining amount (18) ethyl alcohol 5.0
(19) Germinated red bean extract (Production Example 2) 2.0
(20) Sohakuhi extract * 2 0.5
(21) Silicic anhydride 3.0
(22) Perfume appropriate amount * 1 Sigma company * 2 Maruzen Pharmaceutical company

(Manufacturing method)
A. Ingredients (13) to (17) are heated and mixed and maintained at 70 ° C.
B. Ingredients (1) to (12) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling C, components (18) to (22) were added and mixed uniformly to obtain an emulsion.

  Examples 3, 4, 5 and Example 6 were skin lotions and emulsions that prevent sunburn spots, buckwheat and aging wrinkles and tarmi by applying to the skin.

Example 7 Ointment (component) (%)
(1) Stearic acid 18.0
(2) Cetanol 4.0
(3) dl-α-tocopherol * 1 0.2
(4) Preservative appropriate amount (5) Triethanolamine 2.0
(6) Glycerin 5.0
(7) Purified water remaining amount (8) Germinated red bean extract (Production Example 2) 1.0
(9) Dipotassium glycyrrhizinate * 2 0.5
(10) Yeast extract * 3 0.5
* 1 Eisai * 2 Maruzen Pharmaceutical

(Manufacturing method)
A. A part of components (5), (6) and (7) is heat mixed and kept at 75 ° C.
B. Ingredients (1) to (4) are heated and mixed and maintained at 75 ° C.
C. Gradually add A to B.
D. While cooling C, components (8) to (10) dissolved in the remainder of component (7) were added to obtain an ointment.

Example 8 Ointment (component) (%)
(1) Stearic acid 18.0
(2) Cetanol 4.0
(3) Preservative appropriate amount (4) Triethanolamine 2.0
(5) Glycerin 5.0
(6) Purified water remaining amount (7) Germinated red bean extract (Production Example 2) 1.0
(8) Toki extract * 1 0.3
(9) Sodium pyrrolidonecarboxylate * 2 0.3
* 1 Made by Nippon Powder Chemical Co., Ltd. * 2 Made by Ajinomoto Co.

(Manufacturing method)
A. A part of components (4), (5) and (6) is heated and mixed and kept at 75 ° C.
B. Ingredients (1) to (3) are heated and mixed and maintained at 75 ° C.
C. Gradually add A to B.
D. While cooling C, components (7) to (9) dissolved in the remainder of component (6) were added to obtain an ointment.

  Examples 7 and 8 were ointments that applied to the skin to prevent tanning, spots, buckwheat, and wrinkles and talmi due to aging.

Example 9 Pack (ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Polyoxypropylene (10 PO) methyl glucoside 5.0
(5) Glycerin 5.0
(6) Purified water remaining amount (7) ethyl alcohol 20.0
(8) Preservative appropriate amount (9) Germinated red bean extract (Production Example 1) 0.5
(10) Perfume appropriate amount

(Manufacturing method)
A. Components (1) to (6) are mixed, heated to 70 ° C., and stirred.
B. Mix components (7) and (8).
C. The above B was added to the previous A, mixed and then cooled to uniformly mix components (9) to (10) to obtain a pack.

Example 10 Pack (ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Polyoxypropylene (10 PO) methyl glucoside 5.0
(5) Glycerin 5.0
(6) Purified water remaining amount (7) Orange flower water * 1 10.0
(8) Ethyl alcohol 20.0
(9) Preservative appropriate amount (10) germinated red bean extract (Production Example 2) 0.2
(11) Daylily extract * 2 0.5
(12) Wheat extract * 3 0.5
(13) Perfume appropriate amount * 1 Esperis * 2 Maruzen Pharmaceutical * 3 Seiwa Kasei

(Manufacturing method)
A. Components (1) to (7) are mixed, heated to 70 ° C. and stirred.
B. Mix components (8) and (9).
C. The above B was added to the previous A, mixed and then cooled to uniformly mix components (10) to (13) to obtain a pack.

  Examples 9 and 10 were packs that prevented sunburn spots, buckwheat, and aging wrinkles and tarmi by applying to the skin.

Example 11 Liquid foundation:
(Ingredient) (%)
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) Preservative appropriate amount (8) Glycerin 5.0
(9) Triethanolamine 1.0
(10) Carboxymethylcellulose 0.2
(11) Bentonite 0.5
(12) Purified water remaining amount (13) Titanium oxide 6.0
(14) Fine particle titanium oxide 2.0
(15) Fine zinc oxide 5.0
(16) Mica 2.0
(17) Talc 4.0
(18) Color pigment 4.0
(19) Germinated red bean extract (Production Example 2) 0.05
(20) Mannitol * 1 0.5
(21) Nicotinamide * 2 0.5
(22) Perfume appropriate amount * 1 Sigma Corporation * 2 Sigma Corporation

(Manufacturing method)
A. Components (1) to (7) are mixed and dissolved.
B. Ingredients (13) to (18) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (8) to (12) are uniformly dissolved and maintained at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (19) to (22) were added to obtain a liquid foundation.

Example 12 Liquid foundation:
(Ingredient) (%)
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) 4-tert-butyl-4′-methoxy dibenzoylmethane 2.0
(8) Retinol palmitate * 1 0.2
(9) Preservative appropriate amount (10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) Purified water remaining amount (15) Titanium oxide 6.0
(16) Fine particle titanium oxide 2.0
(17) Fine zinc oxide 5.0
(18) Mica 2.0
(19) Talc 4.0
(20) Yellow iron oxide 1.0
(21) Black iron oxide 0.05
(22) Bengala 0.5
(23) Germinated red bean extract (Production Example 2) 0.2
(24) Acetic acid-dl-α-tocopherol * 2 0.5
(25) Dibutylhydroxytoluene * 3 0.2
(26) Fragrance appropriate amount * 1 Made by Nippon Roche * 2 Made by Eisai * 3 Made by Sigma

(Manufacturing method)
A. Components (1) to (9) and (24) are mixed and dissolved.
B. Ingredients (15) to (22) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (10) to (14) and (25) are uniformly dissolved and kept at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (23) and (26) were added to obtain a liquid foundation.

Example 13 Sunscreen Latex (Component) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Preservative appropriate amount (7) perfume appropriate amount (8) fine particle titanium oxide 10.0
(9) Fine zinc oxide 10.0
(10) Zirconium oxide 5.0
(11) Polystyrene powder 3.0
(12) Trimethylsiloxysilicic acid 0.5
(13) Dipropylene glycol 3.0
(14) Ethyl alcohol 10.0
(15) Purified water remaining amount (16) Salt 0.2
(17) Germinated red bean extract (Production Example 2) 2.0
(18) Seaweed extract * 1 3.0
* 1 Made by Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Components (1) to (12) are mixed and dispersed.
B. Components (13) to (16) are mixed and dispersed.
C. Add B to A and emulsify uniformly.
D. Components (17) and (18) were added to C to obtain a sunscreen emulsion.

Example 14 Sunscreen emulsion (component) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 10.0
(6) Preservative appropriate amount (7) perfume appropriate amount (8) fine particle titanium oxide 8.0
(9) Fine particle zinc oxide 7.0
(10) Zirconium oxide 5.0
(11) Polystyrene powder 3.0
(12) Trimethylsiloxysilicic acid 0.5
(13) Dipropylene glycol 3.0
(14) Ethyl alcohol 10.0
(15) Purified water remaining amount (16) Salt 0.2
(17) Germinated red bean extract (Production Example 1) 1.0
(18) Phosphoric acid-L-ascorbyl magnesium * 1 3.0
(19) Green tea extract * 2 0.5
* 1 Nikko Chemicals * 2 Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Components (1) to (12) are mixed and dispersed.
B. Components (13) to (16) are mixed and dispersed.
C. Add B to A and emulsify uniformly.
D. Components (17) to (19) were added to C to obtain a sunscreen emulsion.

  Examples 11-14 were liquid foundations and sunscreen emulsions that were applied to the skin to prevent sunburn spots, buckwheat, and wrinkles and talmi due to aging, and to make the skin beautiful and transparent.

Claims (4)

A skin external preparation characterized by containing a germinated red bean-derived component. The skin external preparation according to claim 1, wherein the germinated red soybean raw ingredient is a melanin production inhibitory ingredient. An external preparation for skin, wherein the germinated red bean-derived component is a cell activation component. Furthermore, 1 type or 2 types or more of the medicinal component chosen from a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, and an ultraviolet-ray inhibitor are contained, The any one of Claims 1-3 characterized by the above-mentioned. The skin external preparation as described.