CN110141526B - Moisturizing and anti-wrinkle emulsion and preparation method thereof - Google Patents
Moisturizing and anti-wrinkle emulsion and preparation method thereof Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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Abstract
A moisturizing and anti-wrinkle emulsion and a preparation method thereof belong to the technical field of cosmetic preparations, and comprise the following components in parts by weight: 4-6 parts of hydroxycitric acid; 3-4 parts of salicylic acid; and adjusting the pH to 5-8 by adopting a pH regulator. The emulsion has excellent stability in time. According to the invention, the emulsion which can stably exist under the pH of 5-8 is obtained by compounding the hydroxycitric acid and the salicylic acid, and the defects of poor stability and easy crystallization of the hydroxycitric acid in an emulsion matrix in the prior art are overcome. In addition, the pH value of 5-8 belongs to the neutral range, so that the emulsion has good latitude on the raw materials of the emulsion, and the plastic formability of the emulsion is improved.
Description
Technical Field
The invention belongs to the technical field of cosmetic preparations, and particularly relates to a moisturizing and anti-wrinkle emulsion and a preparation method thereof.
Background
Moisturization refers to the moisturizing of the skin. When the air temperature is reduced, the skin cuticle can not timely regulate enough moisturizing factors, the activity of oil glands is reduced, the oil and water on the face are reduced, the skin can be tightened, and fine wrinkles can even appear under the eyes and near the nose.
The existing emulsion contains a hydrophilic humectant which is used for moistening the skin, preventing the evaporation of the moisture of the skin, improving microcirculation and enhancing the skin moisture.
When the moisturizer is smeared on the skin, the effect is only limited to infiltration of the cuticle, the moisturizing effect is only temporary and cannot lock water, and the moisturizing capability of the cuticle cannot be fundamentally improved.
The outermost layer of the skin is the stratum corneum, outside which there is also a sebum membrane. Either lack of water in the stratum corneum or insufficient secretion of the cortex can result in dry skin. Thus, the skin is dry, probably not simply due to insufficient moisture in the stratum corneum, but rather to insufficient "water lock".
Therefore, there is a need to develop a moisturizing and anti-wrinkle skin care product with the function of improving the moisturizing capability of the stratum corneum.
Disclosure of Invention
The invention aims to overcome the defects and shortcomings and provide a moisturizing and anti-wrinkle emulsion.
The invention also aims to provide a preparation method of the skin care product.
The technical scheme adopted by the invention for achieving the purpose is as follows.
The moisturizing and anti-wrinkle emulsion is characterized by comprising the following components in parts by weight:
4-6 parts of hydroxycitric acid;
3-4 parts of salicylic acid;
and adjusting the pH to 5-8 by adopting a pH regulator.
The moisturizing and anti-wrinkle emulsion further comprises the following components in parts by weight:
0.5-3 parts of octyldodecanol myristate;
0.5-3 parts of PEG-40 hydrogenated castor oil;
1-5 parts of an undaria pinnatifida extract;
40-50 parts of glycerol;
2-4 parts of acrylic acid (ester) copolymer sodium;
1.5-3 parts of a pH regulator;
5-7.6 parts of a skin conditioner;
500-650 parts of deionized water.
The pH regulator comprises at least one of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol and arginine; the weight part of the sodium hydroxide is 0-0.5 part; the weight part of the potassium hydroxide is 0-0.5 part; the weight part of the triethanolamine is 0-0.25 part; the weight part of the aminomethyl propanol is 0.5-1.5 parts; the weight part of the arginine is 0-0.5 part.
The skin conditioner comprises bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate, plant squalane, shea butter and rice protein active polypeptide; the weight part of the bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dimer linoleate is 0.25-0.7 part; the weight portion of the plant squalane is 0.5 portion; the weight part of the shea butter is 0.3-1 part; the weight portion of the rice protein active polypeptide is 3-5.
The bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate, the natural plant squalane, the shea butter and the rice protein active polypeptide are compounded for use, have good affinity with skin, promote skin regeneration, soften, moisten and nourish the skin, effectively prevent water loss, and help to recover the softness and elasticity of the skin.
The skin conditioner also comprises cholesterol and olive oil; 0.25-0.7 parts of cholesterol; the olive fruit oil accounts for 0.5-0.8 part by weight.
A method for moisturizing and anti-wrinkle emulsion is characterized by comprising the following steps:
(1) adding deionized water into a water phase pot, adding PEG-40 hydrogenated castor oil, stirring until the mixture is completely dissolved, adding acrylic acid (ester) copolymer sodium, stirring uniformly, then sequentially adding glycerin and the undaria pinnatifida extract, stirring uniformly, and heating to 60-75 ℃ to obtain a frost-like gel system;
(2) adding a skin conditioner and octyl dodecanol myristate into an oil phase pot, adding to 75-80 ℃, and uniformly stirring to obtain an oil phase material;
(3) pumping the water phase material into an emulsifying pot, sequentially pumping the oil phase material, the pH regulator, the salicylic acid and the hydroxycitric acid into the emulsifying pot while stirring and homogenizing, uniformly stirring the mixture at the temperature of 75-80 ℃, and preserving the temperature for 15-20 minutes to form the moisturizing and anti-wrinkle emulsion of the oil-in-water emulsifying system.
The technical scheme provided by the invention can achieve the following technical effects:
(1) excellent stability over time. According to the invention, the emulsion which can stably exist under the pH of 5-8 is obtained by compounding the hydroxycitric acid and the salicylic acid, and the defects of poor stability and easy crystallization of the hydroxycitric acid in a matrix in the prior art are overcome. In addition, the pH value of 5-8 belongs to the range of neutral, so that the emulsion has good latitude on the raw materials of the emulsion, the plasticity of the emulsion is improved, and the irritation to the skin is low.
(2) The use feeling is fresh and not greasy.
(3) Has good moisture retention capability. The hydroxycitric acid is natural plant extract, and has effects of repairing and relieving skin, keeping moisture, and increasing skin elasticity.
(4) Mild and no irritation, scientific and precise formula, exact efficacy and no toxic or side effect.
(5) Has obvious anti-wrinkle effect and better skin texture improving effect.
Detailed Description
The present invention is described in further detail below.
The moisturizing and anti-wrinkle emulsion comprises the following components in parts by weight:
4-6 parts of hydroxycitric acid;
3-4 parts of salicylic acid;
0.5-3 parts of octyldodecanol myristate;
0.5-3 parts of PEG-40 hydrogenated castor oil;
1-5 parts of undaria pinnatifida extract
40-50 parts of glycerol;
2-4 parts of acrylic acid (ester) copolymer sodium;
1.5-3 parts of a pH regulator;
5-7.6 parts of a skin conditioner;
500-650 parts of deionized water.
Hydroxycitric Acid (HCA) is a natural organic Acid extracted from the fruit of Garcinia plants.
Hydroxycitric acid, a natural plant product, has a long history of eating and medicinal use, and since its affinity for citrate lyase is much higher than that of a natural substrate (citric acid), it preferentially binds to the enzyme, thereby inhibiting the activity of citrate lyase and reducing the formation of fat in vivo, so HCA has good effects in reducing weight, reducing blood lipid, etc., and is used as a main functional component of natural diet food. (see: Yuandong, research on the effective active ingredient monohydroxycitric acid [ J ]. Sichuan foods and fermentations, 2006, 42 (2): 19-23.)
The chemical structural formula of the hydroxycitric acid is as follows:
hydroxycitric acid is known to inhibit adipogenesis. However, hydroxycitric acid is poorly soluble in the emulsion matrix material and crystallizes. According to the invention, the emulsion which can stably exist under the pH of 5-8 is obtained by compounding the hydroxycitric acid and the salicylic acid, and the defects of poor stability and easy crystallization of the hydroxycitric acid in a matrix in the prior art are overcome.
In addition, hydroxycitric acid, which is a natural plant extract, is contained in the emulsion as an emollient agent, and can be retained on the surface layer of the skin, improve the lipid content of the stratum corneum, prevent the skin from being degreased and dried, and simultaneously, has lubricating property, can increase the softness of the skin, has good air permeability, and has a fresh and smooth feeling when used.
Hydroxy citric acid: HCA of Shanghai Bainian Shidan detection technology Limited company is adopted, and the purity is 98.70%.
Salicylic acid has effects of removing cutin, inhibiting bacteria, and resisting inflammation.
Octyl dodecanol Myristate (octyldocecyl myrisate) is a skin-moistening oil and can make skin smooth and soft, and has good skin-friendly property.
The PEG-40 hydrogenated castor oil can uniformly disperse oily substances such as essence, essential oil and the like into water to form a stable and transparent solution, has an emulsifying effect on other components of the skin care product, has a molecular structure with both hydrophilic groups and hydrophobic groups, can change the oily substances into fine forms, and is more comfortable and breathable to use. In addition, it can reduce the skin barrier effect, and the effective active substance can be easily entered into the inner layer of the skin to play the role.
Undaria pinnatifida extract (science Wakame), which is derived from water-soluble essence of Undaria pinnatifida, has precious skin-tendering effect. The Undaria pinnatifida extract is prepared from Undaria pinnatifida of NAT-214 available from Hunan Lanolin biological resources GmbH.
Glycerol is a small molecule moisturizing ingredient, has good moisturizing effect, can retain moisture in the stratum corneum, and helps the skin to retain water by absorbing moisture from the air.
Sodium acrylate copolymer (NSKIN NG) has stabilizing, thickening, moisturizing, and dispersing effects, and can be used in cream, lotion, and foundation; has stable emulsifying body and reduced coating resistance, and is easy to coat. Provides the skin with silky feeling similar to hyaluronic acid, and forms a film on the surface of the skin to slow down the water evaporation. The invention adopts acrylic acid (ester) copolymer sodium produced by EOC company of Belgium, and the model number is Europacif 2150.
The pH regulator comprises at least one of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, and arginine.
Preferably, the weight part of the sodium hydroxide is 0-0.5 part; the weight part of the potassium hydroxide is 0-0.5 part; the weight part of the triethanolamine is 0-0.25 part; the weight part of the aminomethyl propanol is 0.5-1.5 parts; the weight part of the arginine is 0-0.5 part. The pH of the emulsion is adjusted to 5-8 by adopting a pH regulator, and a stable state is maintained under the neutral pH.
Skin conditioner for improving skin moisture retention and defense ability. The skin care product is a mixed concentrate of bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleyl dimer linoleate, vegetable squalane, shea butter, rice protein active polypeptide, cholesterol and olive oil, is similar to the structure of a skin cuticle sebum membrane, exerts a synergistic effect, strengthens the skin barrier function, and helps to improve skin sensitivity.
The skin conditioner consists of bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate, vegetable squalane, shea butter, rice protein active polypeptide, cholesterol and olive oil.
The weight part of the bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dimer linoleate is 0.25-0.7 part; the weight portion of the plant squalane is 0.5 portion; the weight part of the shea butter is 0.3-1 part; the weight part of the rice protein active polypeptide is 3-5 parts; 0.25-0.7 parts of cholesterol; the olive fruit oil accounts for 0.5-0.8 part by weight.
The di-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate is a product of dimer linoleate capped by behenyl alcohol, isostearyl alcohol and phytosterol mixed alcohol, can moisten skin and prevent evaporation of moisture on the surface of the skin, and has a good moisturizing effect. The phytosterol ester has a structure similar to that of human skin sterol, is an important component of human tissue cells, has a good barrier effect on skin, and can protect the skin from the influence of external environment. The phytosterol ester can form liquid crystal structure, has high permeability to skin, increases skin elasticity, reduces pachylosis, retains skin surface moisture, inhibits dermatitis, promotes wound healing, and prevents erythema solare, skin aging, and chap.
The plant squalane is derived from olive oil, is a natural skin moistening oil, is a lipid close to sebum of a human body, has strong affinity, can be integrated with the sebum membrane of the human body, forms a layer of natural barrier on the surface of the skin, can inhibit the peroxidation of skin lipid, can effectively permeate into the skin, promotes the proliferation of basal cells of the skin, and has obvious physiological effects on delaying the skin aging and improving and eliminating chloasma.
Rice protein active polypeptide is a mixture of bioactive peptide and natural carbohydrate. By protecting and repairing DNA, the cell activity is enhanced, and the cell life is prolonged; inducing the collagen to regenerate and protecting the collagen from being degraded, thereby enhancing the extracellular matrix and achieving the effects of fading wrinkles and preventing skin premature senility.
Preferably, in the present scheme, the rice protein active polypeptide can be prepared by the method disclosed in chinese patent publication No. CN 103045707A.
The specific component types in the technical scheme are only an example of one application of the components, and are not limited.
The shea butter is rich in unsaturated fatty acid, can enhance the moisture retention capacity of skin, and can moisten dry and cutin-damaged skin.
Cholesterol can form liquid crystal structure, has high permeability to skin, increases skin elasticity, reduces pachylosis, retains skin surface moisture, inhibits scytitis, promotes wound healing, and prevents erythema solare, skin aging, and chapping.
The olive fruit oil is rich in unsaturated fatty acid and various vitamins, is easy to be absorbed by skin, contains polyphenols and has antioxidant effect. It can effectively avoid the color spot and wrinkle caused by cell aging due to fat oxidation.
The embodiment of the application has better effects of moisturizing, moistening, resisting wrinkles and the like on the skin through the hydroxycitric acid, the salicylic acid, the pH regulator and the skin conditioner which are in proper proportion.
The following amounts (parts by weight) are used in the examples of the invention:
the preparation method of the moisturizing and anti-wrinkle emulsion comprises the following steps: (1) adding deionized water into a water phase pot, adding PEG-40 hydrogenated castor oil, stirring until the mixture is completely dissolved, adding acrylic acid (ester) copolymer sodium, uniformly stirring, then sequentially adding glycerin and the undaria pinnatifida extract, uniformly stirring, and heating to 60-75 ℃ to obtain a cream gel system;
(2) adding a skin conditioner and octyl dodecanol myristate into an oil phase pot, adding to 75-80 ℃, and uniformly stirring to obtain an oil phase material;
(3) pumping the water phase material into an emulsifying pot, sequentially pumping the oil phase material, the pH regulator, the salicylic acid and the hydroxycitric acid into the emulsifying pot while stirring and homogenizing, uniformly stirring the mixture at the temperature of 75-80 ℃, and preserving the temperature for 15-20 minutes to form the moisturizing and anti-wrinkle emulsion of the oil-in-water emulsifying system.
The finished product prepared according to the embodiment of the invention has obvious effect, good sense, moderate pH value and thickness and stable quality, and the indexes of the embodiment 5 are the best embodiment of the invention.
First, pH test of physical and chemical indexes
The pH measurements were carried out for examples 1-5, comparative examples 1-2, and the results are shown in the following table:
discussion of the experiments: the pH values of the samples of examples 1 to 5 and comparative examples 1 to 2 were in the range of about 6.20, and the pH values were near neutral and relatively mild.
Second, evaluation of moisturizing efficacy
The experimental method comprises the following steps:
the subjects had a total of 60 individuals, and the specific sex and age composition were determined at random, and no adverse reaction was observed at the test sites during the test period.
1. 30 subjects were selected with the left and right arm cycle markers sequentially: test area example group (skin care product made according to any of the examples of the present invention) and blank control area;
the remaining 30 subjects were selected for left and right arm cycle labeling: test area control group (skin care product made from any of the inventive controls) and blank control area.
2. The technician uses the skin moisture test Corneometer CM825 and the water loss through skin test Tewameter TM300 to measure the test area and the blank area, respectively, and averages and records as the initial value.
3. The test part of the subject cleaned by clear water is smeared with the sample to be tested, and the blank control area is not smeared with any sample.
4. Subjects after one hour, two hours, four hours of continuous use of the emulsion, the test area and the blank control area were measured 5 times by the technician using the skin moisture meter CM825, the water loss through the skin tester TM300, respectively, and averaged.
5. And counting the measured values, and analyzing the change rule of skin moisture and moisture loss.
And (4) analyzing results:
the change of the moisture content is reflected in the test period, and the moisture content of the experimental area changes along with the time law. The larger the value, the larger the moisture content, and conversely, the smaller the moisture content. Difference in water content (Δ T) = water content (T) at each point in time after use of the producth) Water content (T) before use of the product0）。
The difference between the water content of the example group, the control group and the blank group and the initial value
The moisture content of the example group was significantly higher than that of the control example group and the blank example group, and the moisture content of the example group was maintained at a higher level, and the moisturizing effect was significant.
Third, evaluation of anti-wrinkle efficacy
The experimental method comprises the following steps:
the subjects were 64 persons in total. The specific gender consisted of a random determination. If2 people have adverse reactions in the period, the test is stopped; no adverse reaction was found. After the skin care product prepared by any embodiment of the invention is applied to a subject, the roughness of the skin is obviously improved.
1. The left and right mouth corners of 32 subjects were selected as the test areas. Each subject had a test sample (skin care product prepared according to any of the examples of the present invention) applied to the left corner of the mouth as an example group and a blank group without any sample applied to the right corner of the mouth.
The left and right mouth corners of the remaining 32 subjects were selected as the test areas. The test sample (skin care product prepared in any one of the control examples of the present invention) was applied to the left mouth corner of each subject as a control group, and the right mouth corner was not applied with any sample as a blank control group.
2. The technicians use a MicroSkin II multifunctional skin mirror image analysis system and a skin moisture content tester to measure the skin texture degree of the experimental part before the emulsion is applied.
3. The test product is applied to the test area (same area) cleaned by clean water in the morning and evening every day, and the test subject cannot smear any emulsion except the tested sample on the test part during the test period.
4. After the subjects continuously applied the emulsion for one week, two weeks, three weeks and four weeks, the subjects cleaned the smeared sites at the same time every week, and the smeared sites were measured by the testers using a MicroSkin ii multifunctional skin mirror image analysis system and a skin moisture content tester.
5. And counting the values measured at the experimental part of the subject each time, and analyzing the change rule of the skin texture degree and the moisture content.
The experimental results are as follows:
skin texture mean values of example, control and blank groups
The skin roughness of the test area was decreasing after the test group samples were applied for 4 weeks of the test period. The rate of change of skin roughness was-6.50% after 4 weeks of sample use, with significant differences from the initial values (p < 0.05).
Fourth, emulsion human body patch test
The experimental process comprises the following steps: the subjects were counted for 30 persons, and the specific gender and age were determined at random (meeting the inclusion and exclusion criteria of "diagnostic criteria and treatment principles for cosmetic contact dermatitis").
A qualified patch material is selected, a sample prepared according to any embodiment of the invention is placed in a patch tester (the sample dosage is 0.020-0.025 g), and a control hole is blank (no substance is placed). Both the sample and the blank were applied to the curved side of the forearm of the subject and gently pressed with the palm to apply evenly on the skin for 24 h. Removing the patch applicator, keeping the interval for 30min, and observing skin reaction after the indentation disappears. The skin reaction was observed once more 24h and 48h after patch test, respectively.
And (3) judging standard:
and (3) classifying and judging according to the cosmetic contact dermatitis diagnosis standard and treatment principle: the non-reaction of the tested part is (0), the skin has reddish spots (1), the skin has erythema, infiltration or papule (2), the skin has edematous erythema and papule (3), and the skin has obvious redness, swelling, pimple or bulla (4).
In 30 cases, the number of people with grade 2 adverse reactions on skin is more than 2, or any 1 case with grade 3 or more than 3 adverse reactions on skin, and the tested substance is judged to have adverse reactions on human body.
The specific results are evaluated as shown in the following table:
0.5 hour observation of the plaque remover
24-hour observation of the despeckle tester
48-hour observation result of the spot-removing tester
The experimental results show that: according to the sample patch test result in the experiment, according to the requirements of 2007 cosmetic hygiene Specifications, the eye anti-wrinkle skin care product provided by the invention is judged to have no adverse reaction on human skin.
Fifth, stability test
The skin care products of examples 1 to 5 and comparative examples 1 to 2 were subjected to a thermostat at 5 ℃ and 45 ℃ for three months, respectively, and then observed for changes in appearance.
X: indicating that crystal precipitation or aggregation was observed.
VI, viscosity test
The use tests of examples 1 to 5 and comparative examples 1 to 2 were conducted by a female expert group (20 persons), and the non-tackiness quality was evaluated according to the following criteria.
O ^ O: 14 to 17 people think they do not feel slimy.
The trade session: 9-13 people think they do not feel slimy.
X: the number of people judged that the composition had no sticky feeling was 8 or less.
The present invention has been described in terms of embodiments, and several variations and modifications can be made to the device without departing from the principles of the present invention. It should be noted that all the technical solutions obtained by means of equivalent substitution or equivalent transformation, etc., fall within the protection scope of the present invention.
Claims (2)
1. The moisturizing and anti-wrinkle emulsion is characterized by comprising the following components in parts by weight:
4-6 parts of hydroxycitric acid;
3-4 parts of salicylic acid;
and adjusting the pH to 5-8 by using a pH regulator;
0.5-3 parts of octyldodecanol myristate;
0.5-3 parts of PEG-40 hydrogenated castor oil;
1-5 parts of an undaria pinnatifida extract;
40-50 parts of glycerol;
2-4 parts of acrylic acid (ester) copolymer sodium;
1.5-3 parts of a pH regulator;
5-7.6 parts of a skin conditioner;
500-650 parts of deionized water;
the preparation method of the moisturizing and anti-wrinkle emulsion comprises the following steps:
(1) adding deionized water into a water phase pot, adding PEG-40 hydrogenated castor oil, stirring until the mixture is completely dissolved, adding acrylic acid (ester) copolymer sodium, stirring uniformly, then sequentially adding glycerin and the undaria pinnatifida extract, stirring uniformly, and heating to 60-75 ℃ to obtain a frost-like gel system;
(2) adding a skin conditioner and octyl dodecanol myristate into an oil phase pot, adding to 75-80 ℃, and uniformly stirring to obtain an oil phase material;
(3) pumping the water phase material into an emulsifying pot, sequentially pumping the oil phase material, the pH regulator, the salicylic acid and the hydroxycitric acid into the emulsifying pot while stirring and homogenizing, uniformly stirring the mixture at the temperature of 75-80 ℃, and preserving the temperature for 15-20 minutes to form the moisturizing and anti-wrinkle emulsion of the oil-in-water emulsifying system;
the skin conditioner comprises bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate, plant squalane, shea butter and rice protein active polypeptide; the weight part of the bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dimer linoleate is 0.25-0.7 part; the weight portion of the plant squalane is 0.5 portion; the weight part of the shea butter is 0.3-1 part; the weight part of the rice protein active polypeptide is 3-5 parts;
the skin conditioner also comprises cholesterol and olive oil; 0.25-0.7 parts of cholesterol; the olive fruit oil accounts for 0.5-0.8 part by weight.
2. The moisturizing and anti-wrinkle emulsion according to claim 1, wherein the pH adjusting agent comprises at least one of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine; the weight part of the sodium hydroxide is 0-0.5 part; the weight part of the potassium hydroxide is 0-0.5 part; the weight part of the triethanolamine is 0-0.25 part; the weight part of the aminomethyl propanol is 0.5-1.5 parts; the weight part of the arginine is 0-0.5 part.
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| WO2006033476A1 (en) * | 2004-09-24 | 2006-03-30 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
| CN101193629A (en) * | 2005-03-24 | 2008-06-04 | 位相转换有限公司 | A topical composition and its uses |
| CN108567641A (en) * | 2018-07-07 | 2018-09-25 | 佛山市芊茹化妆品有限公司 | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water |
| CN108653142A (en) * | 2018-07-01 | 2018-10-16 | 佛山文森特知识产权服务有限公司 | A kind of moisture-keeping composition |
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| US20100331412A1 (en) * | 2009-03-30 | 2010-12-30 | Patricia Lawler Kenet | Two container skin care product |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006033476A1 (en) * | 2004-09-24 | 2006-03-30 | Showa Denko K.K. | Hydroxycitric acid derivatives and skin external preparations containing the same |
| CN101193629A (en) * | 2005-03-24 | 2008-06-04 | 位相转换有限公司 | A topical composition and its uses |
| CN108653142A (en) * | 2018-07-01 | 2018-10-16 | 佛山文森特知识产权服务有限公司 | A kind of moisture-keeping composition |
| CN108567641A (en) * | 2018-07-07 | 2018-09-25 | 佛山市芊茹化妆品有限公司 | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water |
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