CN110496065A - Moisturizing composition - Google Patents
Moisturizing composition Download PDFInfo
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- CN110496065A CN110496065A CN201910805230.8A CN201910805230A CN110496065A CN 110496065 A CN110496065 A CN 110496065A CN 201910805230 A CN201910805230 A CN 201910805230A CN 110496065 A CN110496065 A CN 110496065A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of moisturizing composition, and the composition includes beta glucan, urea, panthenol, trehalose and Sodium Hyaluronate.Moisturizing composition of the present invention is safe, non-stimulated, has not only been able to satisfy instant moistening effect, but also is able to satisfy long-term moistening effect, and can use for a long time.
Description
Technical field
The present invention relates to skin care fields, and in particular to a kind of moisturizing composition and its application.
Background technique
With the quickening of modern life rhythm, more and more young man's work and rests are irregular, and skin becomes sensitive, fragile.
Therefore there is a large amount of replenishing water and preserving moisture class on the market in one of the transient cause that dry skin water shortage becomes skin sensitivity fragility
Product.
Skin is the maximum organ of human body, not only acts as effect or the personal health looks standard of beauty of protection skin,
Especially face skin not only influences skin appearance when skin water shortage, drying, but also also results in the subjective appearance of consumer
Discomfort, and be possible to cause certain dermopathic deteriorations, lead to the aging in advance of skin.It hydration status in skin and dissipates
Mistake degree is soft and moist and elastic directly related with skin, keeps the wet degree of skin that skin elasticity can be enhanced, makes skin generation
Thank to normal, the generation of reduction wrinkle and color spot.Moisture-keeping efficacy is the most basic function of skin protection cosmetics, how to improve skin care item
Moisture-keeping efficacy is all of great significance to the research and development of skin care item and clinical medicine application.
With the continuous improvement of today's society economic level and enriching for material life, people increasingly pay attention to the outer of individual
In image, therefore, skin care item also become doting on for numerous women therewith, show various skin care item types in the market,
Such as facial cleanser (frost/cream), lotion, toner, facial mask, face cream, mascara.For product of single type, producer is also developed not
The product of congenerous type, such as whitening, nti-freckle, moisturizing and oil-control.
Most of existing moisturizing product is all pure water dosage form, and this dosage form defect is to lack long-term moisturizing effect, have
There are also a large amount of alcohol to be used as solvent, the bad raw material of dissolution water solubility reaches the moisturizing effect of product, but for sensitivity
Skin is not applicable, and cannot preferably reach moistening effect, keeps skin more sensitive after long-time service, assimilation effect is poor.
Patent CN110037929A discloses a kind of moisturizing maintenance essence stick, including following component: dimethyl silicone polymer,
The poly- trimethicone of diphenyl silicon phenyl, ceresin, neopentyl glycol two (thylhexoic acid) ester, the different nonyl of isononanoic acid
Ester, PEG-9 Polydimethylsiloxyethyl Dimethicone, vinyldimethicone/polymethyl siloxane silicon times
Half oxygen alkane cross-linked polymer, candelila wax, trimethyl silicane alkoxy esters of silicon acis, tocopherol；Hydrolecithin, Wild soybean sterol
Class, Cer AP II, Cer NS, Cer NP, Cer EOS；Water, 1,3-BDO, glycerol, sodium chloride, benzoic acid
Sodium, trehalose, dipotassium glycyrrhizinate, palmityl tripeptides -5, alpha-glucans oligosaccharides；Phenoxyethanol.Patent CN110037929A is provided
Moisturizing maintenance essence stick, it is easy to carry, can nurse skin whenever and wherever possible, it is collection moisture-keeping crease-shedding, anti-oxidant anti-saccharification, anti-inflammatory anti-
Quick radiation protection is in one.The moisturizing maintenance essence stick fat content for the emulsion system that patent CN110037929A is provided is more, no
Greasy spreadability is poor when being easy to absorb, and using.
Therefore, it is necessary to a kind of safe, non-stimulated, it was not only able to satisfy instant moistening effect, but also be able to satisfy long-term moistening effect, and
The moisturizing composition that can be used for a long time.
Summary of the invention
In view of this, it had not only been able to satisfy instant moistening effect the purpose of the present invention is to provide a kind of safe, non-stimulated, but also
The moisturizing composition that is able to satisfy long-term moistening effect, and can use for a long time, can preferably improve skin condition.
For this purpose, the present invention provides following technical schemes.
In a first aspect, the present invention provides a kind of moisturizing compositions, wherein the composition include beta glucan, urea,
Panthenol, trehalose and Sodium Hyaluronate.
In a preferred embodiment, the composition also includes moisturizer, antioxidant, skin conditioning agent, thickener
And preservative, wherein
The moisturizer is selected from one of glycerol and 1,2- pentanediol or a variety of；
The antioxidant is selected from one of tocopherol and ubiquinone or a variety of；
The skin conditioning agent is selected from one of tranexamic acid and purslane extract or a variety of；
The thickener is selected from polyacrylate cross-linked polymer -6, the tert-butyl alcohol and ammonium acryloyldime-thyltaurate/VP copolymerization
One of object is a variety of；
The preservative is selected from one of methyl esters and Phenoxyethanol or a variety of.
In a preferred embodiment, according to parts by weight, the composition includes:
0.1-2 parts of beta glucans, 0.1-1 parts of urea, 1-10 parts of panthenols, 0.1-0.3 portions of trehaloses and 0.05-0.4 parts of hyalomitomes
Sour sodium.
In a preferred embodiment, according to parts by weight, the composition also includes:
2-5 parts of moisturizer, 0.05-0.4 parts of antioxidants, 0.5-1 parts of skin conditioning agents, 0.15-0.2 parts of thickeners and 0.1-
0.3 portion of preservative.
Second aspect, the present invention provides a kind of moisturizing compositions, wherein the composition includes:
Moisturizer, beta glucan, urea, panthenol, trehalose, Sodium Hyaluronate, skin conditioning agent, thickener, is prevented antioxidant
Rotten agent and water.
The third aspect, the present invention provides a kind of moisturizing compositions, wherein according to parts by weight, the composition includes:
2-5 parts of moisturizer, 0.05-0.4 parts of antioxidants, 0.1-2 parts of beta glucans, 0.1-1 parts of urea, 1-10 parts of panthenols, 0.1-0.3
Portion trehalose, 0.05-0.4 part Sodium Hyaluronates, 0.5-1 parts of skin conditioning agents, 0.15-0.2 parts of thickeners, 0.1-0.3 parts prevent
Rotten agent and suitable quantity of water.
Fourth aspect, the present invention provides a kind of preparation method of moisturizing composition, the method is comprised the steps of:
S1. water, Sodium Hyaluronate, trehalose, urea, preservative, thickener and moisturizer are sequentially added in container and is mixed, added
Heat is stirred evenly to 80-85 DEG C, is kept the temperature 10-20min, is cooled to 38-41 DEG C, obtains A phase；
S2. A phase is added in antioxidant, stirs 2-3min, homogeneous 2-3min, determining mixture no longer wall built-up, then homogeneous is complete,
8-10min is stirred, B phase is obtained；
S3. skin conditioning agent, beta glucan, panthenol and preservative are mixed evenly, obtain C phase；
S4. C phase is mixed with B, stirs 28-32min, stirs evenly, be cooled to room temperature；
Wherein,
The moisturizer is selected from one of glycerol and 1,2- pentanediol or a variety of；
The antioxidant is selected from one of tocopherol and ubiquinone or a variety of；
The skin conditioning agent is selected from one of tranexamic acid and purslane extract or a variety of；
The thickener is selected from polyacrylate cross-linked polymer -6, the tert-butyl alcohol and ammonium acryloyldime-thyltaurate/VP copolymerization
One of object is a variety of；
The preservative is selected from one of methyl esters and Phenoxyethanol or a variety of.
5th aspect, provides a kind of skin-protection product, and the skin-protection product includes moisturizing composition of the present invention.
6th aspect, provides a kind of pharmaceutical composition, and described pharmaceutical composition includes safe and effective amount such as the present invention
The moisturizing composition.
Further it is provided that moisturizing composition of the present invention is preparing the purposes in skin-protection product.
And additionally provide purposes of the moisturizing composition of the present invention in preparation pharmaceutical composition.
Referring now to the prior art, the beneficial effects of the present invention are be:
The Sodium Hyaluronate that moisturizing composition of the present invention includes has very strong water holding capacity as natural macromolecular moisturizer,
Skin can be made to keep skin moisturizing smooth within a certain period of time, fine and smooth tender, high resilience；Beta glucan has anti-ageing anti-wrinkle,
Promote wound healing and scar desalination, antiallergic antiinflammation；Urea can be such that keratolysis is denaturalized, and promote the hydration of cuticula
Effect, to make skin emolliency, prevents dry and cracked；Trehalose belongs to small molecule moisturizer, has good compatibility, energy with memebrane protein
The aquation function of enough increasing cell, there is good moisture retention, in dry conditions can cell surface formed one layer it is special
Protective film, aquation can also be played the role of in dehydration instead of moisture in cell, with Bound Water Moleculess to protect
Shield Skin Cell will not be damaged；Panthenol can stimulate the growth of epithelial cell as the moisturizer penetrated deep into, and wound is promoted to be cured
It closes, to play antiinflammation.
The antioxidant that moisturizing composition of the present invention includes, has the function of anti-aging.When body aging, it can go out into the cell
The pigment granule of existing brown, increases with the growth at age, and this pigment granule may be since unsaturated fat acid oxidase is raw
At lipid peroxide, compound is combined into protein and is put aside in the cell.Antioxidant of the present invention can prevent unsaturated fat
Acid oxidase maintains the integrality and normal function of the more cell membrane containing unsaturated fatty acid.
The skin conditioning agent that moisturizing composition of the present invention includes, for antiallergy, anti-inflammatory anti-inflammatory and anti-outer bound pair skin
Various stimulations especially have apparent anti-allergic effects to the skin allergy that the generation of steroids cosmetics is used for a long time.
Most of existing moisturizing product is all pure water dosage form or common lotion, and this dosage form defect is to lack length
Phase moisturizing effect, there are also a large amount of alcohol for some as solvent, and the water-soluble bad raw material of dissolution reaches the moisturizing effect of product
Fruit, but it is not applicable for sensitive skin, and cannot preferably reach moistening effect, keep skin more sensitive after long-time service,
Assimilation effect is poor, and the present invention is not only able to satisfy instant moistening effect to improve formula safety and product efficacy as starting point, but also
It is able to satisfy long-term moistening effect, and can be used for a long time, it is small by being formed after thickener and antioxidant homogeneous by microemulsion dosage
Urea, panthenol, trehalose, beta glucan and Sodium Hyaluronate efficacy factor are transported to deep skin, while thickener by drop
The skin sense of product can be made to become more to moisten with moisturizer, the moisture of skin can be made not volatile, it being capable of long-acting moisturizing.
In another aspect, by screening moisturizing composition in component type and adjustment moisturizing composition in component parts by weight
Number, moisturizing composition of the present invention can preferably play replenishing water and preserving moisture effect.
Specific embodiment
Below in conjunction with specific embodiment and embodiment, it is specifically described the present invention, advantages of the present invention and various effects
It thus more will clearly present.It will be understood by those skilled in the art that these specific embodiments and embodiment are for illustrating
The present invention is not intended to limit the present invention.
Throughout the specification, unless otherwise specified, terms used herein are interpreted as usual in this field
Used meaning.As a result, unless otherwise defined, all technical and scientific terms used herein has leads with belonging to the present invention
The identical meaning of the general understanding of field technique personnel.Contradiction if it exists, this specification are preferential.
THICKENERS Thickeners can generate important influence to the mode of appearance of product.Thickener by with surface-active dosage form
At rod-shaped micelle, with water act on the three-dimensional aquation network structure to be formed, or using the macromolecular backbone etc. of itself, make body
System achievees the purpose that thickening.
For the type of thickener, the present invention is selected from polyacrylate cross-linked polymer -6, the tert-butyl alcohol and acryloyl diformazan
One of base taurine ammonium/VP copolymer is a variety of.
In the present invention, moisturizer refers to can protect skin to moisturizer, keep skin moisturizing smooth, fine and smooth tender,
Flexible one kind reagent.
For the type of moisturizer, the present invention is selected from glycerol and 1, one of 2- pentanediol or a variety of.
In the present invention, antioxidant refers to can prevent or skin care item is delayed to aoxidize antioxidant, improve the steady of skin care item
Qualitative and extension storage period.
For the type of antioxidant, the present invention is selected from one of tocopherol and ubiquinone or a variety of.
In the present invention, skin conditioning agent is the appearance for referring to improve drying/damaged skin to skin conditioning agent, is reduced de-
Skin and recovery skin emolliency, also have effects that anti-irritant, anti-inflammatory and the reagent soothed the skin.
For the type of skin conditioning agent, the present invention is selected from one of tranexamic acid and purslane extract or more
Kind.
In the present invention, preservative refers to growth to inhibit microorganism in moisturizing composition and breeding for mesh to preservative
And the substance that is added in moisturizing composition, for extending the holding time of moisturizing composition.
For the type of preservative, the present invention is selected from one of methyl esters and Phenoxyethanol or a variety of.
In a preferred embodiment, moisturizing composition of the invention is contained in skin-protection product skin-protection product.
Skin-protection product of the invention may include container, operation instructions, using auxiliary agent and/or for progressive as needed
It can the required other structures of test and/or reagent.
Include but is not limited to for being tested for the property required other structures in skin-protection product of the invention, for sampling
Structure, for carrying out contrast structure and/or for Observe and measure process or the structure of result.
Include but is not limited to for being tested for the property other required reagents in skin-protection product of the invention, culture medium,
Detergent, color developing agent and/or terminator, and except thickener of the invention, skin conditioning agent, antioxidant, moisturizer and prevent
Other thickeners, skin conditioning agent, antioxidant, moisturizer and preservative outside rotten agent.
Certainly, it will be understood by those skilled in the art that in addition to the foregoing, moisturizing composition of the present invention may be used also
To include other accessory ingredients, such as free radical scavenger, film forming agent and stabilizer.
In the present invention, pharmaceutical composition includes moisturizing composition of the present invention and pharmaceutically acceptable auxiliary
Material.
In the present invention, safe and effective amount refers to that a certain amount of compound or composition, the amount are enough significantly to induce product
The beneficial effect of pole, preferably positive skin histology appearance or feeling beneficial effect, include herein in form independent or combined
Disclosed beneficial effect, but the amount and sufficiently low to avoid serious side effect, i.e., the model rationally judged in technical staff
The interior reasonable effective hazard ratio of offer is provided.
The present invention is described in more detail by the following examples, but the present invention is not limited to these Examples.
Embodiment 1
The present embodiment provides a kind of moisturizing compositions, wherein according to parts by weight, the composition includes:
2 parts of glycerol, 0.05 part of tocopherol, 0.1 part of beta glucan, 0.1 part of urea, 1 part of panthenol, 0.1 portion of trehalose, 0.05 part thoroughly
Bright matter acid sodium, 0.5 part of purslane extract, 0.15 part of tert-butyl alcohol, 0.1 part of Phenoxyethanol and suitable quantity of water.
The present embodiment moisturizing composition the preparation method is as follows:
S1. by suitable quantity of water, 0.05 part of Sodium Hyaluronate, 0.1 portion of trehalose, 0.1 part of urea, 0.05 part of Phenoxyethanol, 0.15 part
The tert-butyl alcohol and 2 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
To A phase；
S2. A phase is added in 0.05 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete,
10min is stirred, B phase is obtained；
S3. 0.5 part of purslane extract, 0.1 part of beta glucan, 1 part of panthenol and 0.05 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Embodiment 2
The present embodiment provides a kind of moisturizing compositions, wherein according to parts by weight, the composition includes:
5 parts of glycerol, 0.4 part of tocopherol, 2 parts of beta glucans, 1 part of urea, 10 parts of panthenols, 0.3 portion of trehalose, 0.4 part of hyalomitome
Sour sodium, 1 part of purslane extract, 0.2 part of tert-butyl alcohol, 0.3 part of Phenoxyethanol and suitable quantity of water.
The present embodiment moisturizing composition the preparation method is as follows:
S1. by suitable quantity of water, 0.4 part of Sodium Hyaluronate, 0.3 portion of trehalose, 1 part of urea, 0.1 part of Phenoxyethanol, 0.2 part of tert-butyl alcohol
It sequentially adds in container and mixes with 5 parts of glycerol, be heated to 80 DEG C, stir evenly, keep the temperature 15min, be cooled to 40 DEG C, obtain A phase；
S2. A phase is added in 0.4 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 1 part of purslane extract, 2 parts of beta glucans, 10 parts of panthenols and 0.2 part of Phenoxyethanol are mixed evenly, are obtained
C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Embodiment 3
The present embodiment provides a kind of moisturizing compositions, wherein according to parts by weight, the composition includes:
3 parts of glycerol, 0.2 part of tocopherol, 0.5 part of beta glucan, 0.5 part of urea, 3 parts of panthenols, 0.2 portion of trehalose, 0.1 part it is transparent
Matter acid sodium, 0.6 part of purslane extract, 0.16 part of tert-butyl alcohol, 0.2 part of Phenoxyethanol and suitable quantity of water.
The present embodiment moisturizing composition the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.1 part of Phenoxyethanol, 0.16 part of uncle
Butanol and 3 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
A phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.1 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Embodiment 4
The present embodiment provides a kind of skin-protection products, wherein according to parts by weight, the skin-protection product includes:
2 parts of glycerol, 0.05 part of tocopherol, 0.1 part of beta glucan, 0.1 part of urea, 1 part of panthenol, 0.1 portion of trehalose, 0.05 part thoroughly
Bright matter acid sodium, 0.5 part of purslane extract, 0.15 part of tert-butyl alcohol, 0.1 part of Phenoxyethanol and suitable quantity of water.
The present embodiment skin-protection product the preparation method is as follows:
S1. by suitable quantity of water, 0.05 part of Sodium Hyaluronate, 0.1 portion of trehalose, 0.1 part of urea, 0.05 part of Phenoxyethanol, 0.15 part
The tert-butyl alcohol and 2 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
To A phase；
S2. A phase is added in 0.05 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete,
10min is stirred, B phase is obtained；
S3. 0.5 part of purslane extract, 0.1 part of beta glucan, 1 part of panthenol and 0.05 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Embodiment 5
The present embodiment provides a kind of skin-protection products, wherein according to parts by weight, the skin-protection product includes:
5 parts of glycerol, 0.4 part of tocopherol, 2 parts of beta glucans, 1 part of urea, 10 parts of panthenols, 0.3 portion of trehalose, 0.4 part of hyalomitome
Sour sodium, 1 part of purslane extract, 0.2 part of tert-butyl alcohol, 0.3 part of Phenoxyethanol and suitable quantity of water.
The present embodiment skin-protection product the preparation method is as follows:
S1. by suitable quantity of water, 0.4 part of Sodium Hyaluronate, 0.3 portion of trehalose, 1 part of urea, 0.1 part of Phenoxyethanol, 0.2 part of tert-butyl alcohol
It sequentially adds in container and mixes with 5 parts of glycerol, be heated to 80 DEG C, stir evenly, keep the temperature 15min, be cooled to 40 DEG C, obtain A phase；
S2. A phase is added in 0.4 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 1 part of purslane extract, 2 parts of beta glucans, 10 parts of panthenols and 0.2 part of Phenoxyethanol are mixed evenly, are obtained
C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Embodiment 6
The present embodiment provides a kind of skin-protection products, wherein according to parts by weight, the skin-protection product includes:
3 parts of glycerol, 0.2 part of tocopherol, 0.5 part of beta glucan, 0.5 part of urea, 3 parts of panthenols, 0.2 portion of trehalose, 0.1 part it is transparent
Matter acid sodium, 0.6 part of purslane extract, 0.16 part of tert-butyl alcohol, 0.2 part of Phenoxyethanol and suitable quantity of water.
The present embodiment skin-protection product the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.1 part of Phenoxyethanol, 0.16 part of uncle
Butanol and 3 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
A phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.1 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Comparative example 1
Beneficial effect in order to further illustrate the present invention provides a kind of moisturizing maintenance essence stick, which is
Using the method preparation in patent CN110037929A.
Comparative example 2
Beneficial effect in order to further illustrate the present invention provides comparative example 2 and compares with embodiment 3, the difference of the comparative example 2
It is: Phenoxyethanol of the invention is replaced with into salicylic acid.
2 moisturizing composition of comparative example the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.1 part of salicylic acid, 0.16 part of tertiary fourth
Pure and mild 3 parts of glycerol, which sequentially adds in container, to be mixed, and is heated to 80 DEG C, is stirred evenly, and is kept the temperature 15min, is cooled to 40 DEG C, obtains A
Phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.1 part of salicylic acid are mixed evenly, are obtained
To C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Comparative example 3
Beneficial effect in order to further illustrate the present invention provides comparative example 3 and compares with embodiment 3, the difference of the comparative example 3
It is: the parts by weight of preservative of the present invention is adjusted to 0.05 part.
3 moisturizing composition of comparative example the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.02 part of Phenoxyethanol, 0.16 part of uncle
Butanol and 3 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
A phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.03 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Comparative example 4
Beneficial effect in order to further illustrate the present invention provides comparative example 4 and compares with embodiment 3, the difference of the comparative example 4
It is: the parts by weight of preservative of the present invention is adjusted to 0.5 part.
4 moisturizing composition of comparative example the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.3 part of Phenoxyethanol, 0.16 part of uncle
Butanol and 3 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
A phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.2 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Comparative example 5
Beneficial effect in order to further illustrate the present invention provides comparative example 5 and compares with embodiment 6, the difference of the comparative example 5
It is: Phenoxyethanol of the invention is replaced with into salicylic acid.
5 skin-protection product of comparative example the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.1 part of salicylic acid, 0.16 part of tertiary fourth
Pure and mild 3 parts of glycerol, which sequentially adds in container, to be mixed, and is heated to 80 DEG C, is stirred evenly, and is kept the temperature 15min, is cooled to 40 DEG C, obtains A
Phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.1 part of salicylic acid are mixed evenly, are obtained
To C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Comparative example 6
Beneficial effect in order to further illustrate the present invention provides comparative example 6 and compares with embodiment 6, the difference of the comparative example 3
It is: the parts by weight of preservative of the present invention is adjusted to 0.05 part.
6 skin-protection product of comparative example the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.02 part of Phenoxyethanol, 0.16 part of uncle
Butanol and 3 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
A phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.03 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Comparative example 7
Beneficial effect in order to further illustrate the present invention provides comparative example 7 and compares with embodiment 6, the difference of the comparative example 7
It is: the parts by weight of preservative of the present invention is adjusted to 0.5 part.
7 skin-protection product of comparative example the preparation method is as follows:
S1. by suitable quantity of water, 0.1 part of Sodium Hyaluronate, 0.2 portion of trehalose, 0.5 part of urea, 0.3 part of Phenoxyethanol, 0.16 part of uncle
Butanol and 3 parts of glycerol are sequentially added in container and are mixed, and are heated to 80 DEG C, are stirred evenly, and are kept the temperature 15min, are cooled to 40 DEG C, obtain
A phase；
S2. A phase is added in 0.2 part of tocopherol, stirs 3min, homogeneous 2min, determining mixture no longer wall built-up, then homogeneous is complete, stirs
10min is mixed, B phase is obtained；
S3. 0.6 part of purslane extract, 0.5 part of beta glucan, 3 parts of panthenols and 0.2 part of Phenoxyethanol are mixed evenly,
Obtain C phase；
S4. C phase is mixed with B, stirs 30min, stirs evenly, be cooled to room temperature.
Experiment 1: safety evaluatio (skin wrinkle is sturdy to be tested)
Experimental subjects: choose 260 volunteers, the age between 20-65 years old, volunteer's skin health, no skin disease allergies,
Meet subject's aspiration and is selected into standard.Random grouping, is divided into 13 groups, every group of 20 people.
Experimental principle: referring to Part V human safety in " cosmetics health specification 2015 editions " and efficacy assessments detection
Safety of the human skin patch method validation facial mask for human skin in method, sturdy test of skin wrinkle is measurement body
A kind of diagnostic mode of delayed contact allergy is set according to IV type skin allergic reaction principle.
Given the test agent: the moisturizing composition of embodiment 1-3, comparative example 2-4 preparation, embodiment 4-6, comparative example 5-7 preparation
Skin-protection product.
Experimental method: subject's right forearm bends the side label region 5cm × 5cm and uses 75% alcohol disinfecting, to mark zone
Wound is made in domain, makes wound method are as follows: uses nutrient solution and the factor, 36 needle microneedles import 30s, and the cotton balls infiltrated using physiological saline is light
Residual liquid is wiped, keeps marked region dry；Spot tester cell number 0-15, is respectively put into 1-15 spot tester for given the test agent
In cell, dosage 0.020-0.025g, inquiry subject's impression, tested period forbids taking a shower, wherein normal is negative reaction,
Experimental result is as shown in table 2 below.
Wherein, skin wrinkle it is sturdy test reaction grade scale it is as shown in table 1 below.
1 skin wrinkle of table is sturdy to test reaction grade scale
2 experimental result of table
Skin wrinkle is sturdy to be tested as the result is shown:
Moisturizing composition of the present invention, skin-protection product observe the dermoreaction of volunteer after use, and the skin of most volunteers is anti-
It should be feminine gender, individual volunteers have a suspicious reaction, only faint erythema, illustrate moisturizing composition of the present invention, skin-protection product
Safety is preferable；And the moisturizing composition of inventive formulation system preparation, skin-protection product is not used, there are some volunteers to occur
Strong positive reaction, positive reaction have exceeded tested area, and safety is poor.
Experiment 2: compliance test result selects the volunteer of 130 dry skins and easy allergy, and wherein age distribution is 25-50
In year, 13 groups of A, B, C, D, E, F, G, H, I, J, K, L, M are randomly divided into, every group of 10 people.Wherein,
The moisturizing composition that the application of A group is prepared by the above embodiment of the present invention 1,
The moisturizing composition that the application of B group is prepared by the above embodiment of the present invention 2,
The moisturizing composition that the application of C group is prepared by the above embodiment of the present invention 3,
The skin-protection product that the application of D group is prepared by the above embodiment of the present invention 4,
The skin-protection product that the application of E group is prepared by the above embodiment of the present invention 5,
The skin-protection product that the application of F group is prepared by the above embodiment of the present invention 6,
The moisturizing maintenance essence stick that the application of G group is prepared by comparative example 1,
The moisturizing composition that the application of H group is prepared by comparative example 2,
The moisturizing composition that the application of I group is prepared by comparative example 3,
The moisturizing composition that the application of J group is prepared by comparative example 4,
The skin-protection product that the application of K group is prepared by comparative example 5,
The skin-protection product that the application of L group is prepared by comparative example 6,
The skin-protection product that the application of M group is prepared by comparative example 7,
It is each using primary daily morning and evening, it is painted with and its mildness is evaluated instantly, test its moisture after moisture content, 8h instantly
Content, for 24 hours rear moisture content carry out after 10 days to skin elasticity, and skin brightness is tested, and every group of test is averaged.It comments
Divide result as shown in table 3 below.
Table 3
It can be seen from the above result that:
Using the volunteer of moisturizing composition of the present invention without any discomfort, mildness evaluation is all full marks.And the present invention is not used
The mildness for being formulated the volunteer of moisturizing composition is evaluated at 8 points or less.
Significantly improved using the facial moisture content of the volunteer of moisturizing composition of the present invention, and using 8h, using for 24 hours
Moisture content is all higher than before using afterwards, and skin elasticity and skin brightness before using also than increasing.Illustrate benefit of the invention
Water composition after continued use, relative to the moisturizing composition of unused inventive formulation system, microemulsion system of the invention
More can skin permeation deep layer, carry out instant moisturizing and long-acting moisturizing, while there is bright color and increase skin elasticity
Effect has preferable skin replenishing water and preserving moisture effect.
Likewise, mildness evaluation is all full marks using the volunteer of skin-protection product of the present invention without any discomfort.And do not make
It is evaluated with the mildness of the volunteer of inventive formulation skin-protection product at 8 points or less.
Significantly improved using the facial moisture content of the volunteer of skin-protection product of the present invention, and using 8h, using after for 24 hours
Moisture content is all higher than before using, and skin elasticity and skin brightness before using also than increasing.Illustrate skin care of the invention
After continued use, relative to the skin-protection product of unused inventive formulation system, microemulsion system of the invention can more seep product
Transdermal deep layer carries out instant moisturizing and long-acting moisturizing, while having the function of bright color and increasing skin elasticity, tool
There is preferable skin replenishing water and preserving moisture effect.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 2.1 to compare with embodiment 3, the difference of the comparative example 2.1 is: skin conditioning agent of the invention is replaced
It is changed to kojic acid；
It provides comparative example 2.2 to compare with embodiment 3, the difference of the comparative example 2.2 is: thickener of the invention is replaced with
Xanthan gum；
It is prepared into moisturizing composition in conjunction with preparation method of the invention, is tested according to the experimental method of experiment 2.Observation comparison
The effect of moisturizing composition prepared by example 2.1, comparative example 2.2.As a result similar in above-mentioned comparative example 2.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 3.1 to compare with embodiment 3, the difference of the comparative example 3.1 is: by the weight of beta glucan of the present invention
Number is adjusted to 0.05 part；
It provides comparative example 3.2 to compare with embodiment 3, the difference of the comparative example 3.2 is: by the parts by weight of panthenol of the present invention
It is adjusted to 0.5 part；
It provides comparative example 3.3 to compare with embodiment 3, the difference of the comparative example 3.3 is: by the parts by weight of trehalose of the present invention
Number is adjusted to 0.05 part；
It is prepared into moisturizing composition in conjunction with preparation method of the invention, is tested according to the experimental method of experiment 2.Observation comparison
The effect of moisturizing composition prepared by example 3.1, comparative example 3.2, comparative example 3.3.As a result similar in above-mentioned comparative example 3.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 4.1 to compare with embodiment 3, the difference of the comparative example 4.1 is: by the weight of beta glucan of the present invention
Number is adjusted to 2.5 parts；
It provides comparative example 4.2 to compare with embodiment 3, the difference of the comparative example 4.2 is: by the parts by weight of panthenol of the present invention
It is adjusted to 11 parts；
It provides comparative example 4.3 to compare with embodiment 3, the difference of the comparative example 4.3 is: by the parts by weight of trehalose of the present invention
Number is adjusted to 0.4 part；
It is prepared into moisturizing composition in conjunction with preparation method of the invention, is tested according to the experimental method of experiment 2.Observation comparison
The effect of moisturizing composition prepared by example 4.1, comparative example 4.2, comparative example 4.3.As a result similar in above-mentioned comparative example 4.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 5.1 to compare with embodiment 6, the difference of the comparative example 5.1 is: skin conditioning agent of the invention is replaced
It is changed to kojic acid；
It provides comparative example 5.2 to compare with embodiment 6, the difference of the comparative example 5.2 is: thickener of the invention is replaced with
Xanthan gum；
It is prepared into skin-protection product in conjunction with preparation method of the invention, is tested according to the experimental method of experiment 2.Observe comparative example
5.1, the effect of skin-protection product prepared by comparative example 5.2.As a result similar in above-mentioned comparative example 5.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 6.1 to compare with embodiment 6, the difference of the comparative example 6.1 is: by the weight of beta glucan of the present invention
Number is adjusted to 0.05 part；
It provides comparative example 6.2 to compare with embodiment 6, the difference of the comparative example 6.2 is: by the parts by weight of panthenol of the present invention
It is adjusted to 0.5 part；
It provides comparative example 6.3 to compare with embodiment 6, the difference of the comparative example 6.3 is: by the parts by weight of trehalose of the present invention
Number is adjusted to 0.05 part；
It is prepared into moisturizing composition in conjunction with preparation method of the invention, is tested according to the experimental method of experiment 2.Observation comparison
The effect of moisturizing composition prepared by example 6.1, comparative example 6.2, comparative example 6.3.As a result similar in above-mentioned comparative example 6.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 7.1 to compare with embodiment 6, the difference of the comparative example 7.1 is: by the weight of beta glucan of the present invention
Number is adjusted to 2.5 parts；
It provides comparative example 7.2 to compare with embodiment 6, the difference of the comparative example 7.2 is: by the parts by weight of panthenol of the present invention
It is adjusted to 11 parts；
It provides comparative example 7.3 to compare with embodiment 6, the difference of the comparative example 7.3 is: by the parts by weight of trehalose of the present invention
Number is adjusted to 0.4 part；
It is prepared into moisturizing composition in conjunction with preparation method of the invention, is tested according to the experimental method of experiment 2.Observation comparison
The effect of skin-protection product prepared by example 7.1, comparative example 7.2, comparative example 7.3.As a result similar in above-mentioned comparative example 7.
It should be understood that the present invention disclosed is not limited only to specific method, scheme and the substance of description, because these
It is alterable.It will also be understood that purpose of the terminology used here just for the sake of the specific embodiment scheme of description, rather than
It is intended to limit the scope of the invention, the scope of the present invention is limited solely by the attached claims.
Those skilled in the art, which will also be appreciated that or be able to confirm that, uses no more than routine experiment, institute herein
The many equivalents for the specific embodiment of the invention stated.These equivalents are also contained in the attached claims.
Claims (10)
1. a kind of moisturizing composition, wherein the composition includes beta glucan, urea, panthenol, seaweed
Sugar and Sodium Hyaluronate.
2. composition according to claim 1, the composition also includes moisturizer, antioxidant, skin conditioning agent, increasing
Thick dose and preservative, wherein the moisturizer is selected from glycerol and 1, one of 2- pentanediol or a variety of；The antioxidant choosing
From one of tocopherol and ubiquinone or a variety of；
The skin conditioning agent is selected from one of tranexamic acid and purslane extract or a variety of；The thickener is selected from polypropylene
One of acid esters cross-linked polymer -6, the tert-butyl alcohol and ammonium acryloyl taurate/VP copolymer are a variety of；The anti-corrosion
Agent is selected from one of methyl esters and Phenoxyethanol or a variety of.
3. composition according to claim 1, wherein according to parts by weight, the composition includes: 0.1-2 parts of β-Portugals
Glycan, 0.1-1 part urea, 1-10 parts of panthenols, 0.1-0.3 portions of trehaloses and 0.05-0.4 parts of Sodium Hyaluronates.
4. composition according to claim 2, wherein according to parts by weight, the composition also includes: 2-5 parts of moisturizings
Agent, 0.05-0.4 parts of antioxidants, 0.5-1 parts of skin conditioning agents, 0.15-0.2 parts of thickeners and 0.1-0.3 portions of preservatives.
5. a kind of moisturizing composition, wherein the composition includes: moisturizer, antioxidant, beta glucan, urea, panthenol,
Trehalose, Sodium Hyaluronate, skin conditioning agent, thickener, preservative and water.
6. a kind of moisturizing composition, wherein according to parts by weight, the composition includes: 2-5 parts of moisturizer, 0.05-0.4 parts
Antioxidant, 0.1-2 part beta glucan, 0.1-1 parts of urea, 1-10 parts of panthenols, 0.1-0.3 portions of trehaloses, 0.05-0.4 parts thoroughly
Bright matter acid sodium, 0.5-1 parts of skin conditioning agents, 0.15-0.2 parts of thickeners, 0.1-0.3 portions of preservatives and suitable quantity of water.
7. a kind of preparation method of moisturizing composition, the method comprise the steps of:
S1. water, Sodium Hyaluronate, trehalose, urea, preservative, thickener and moisturizer are sequentially added in container and is mixed, added
Heat is stirred evenly to 80-85 DEG C, is kept the temperature 10-20min, is cooled to 38-41 DEG C, obtains A phase；
S2. A phase is added in antioxidant, stirs 2-3min, homogeneous 2-3min, determining mixture no longer wall built-up, then homogeneous is complete,
8-10min is stirred, B phase is obtained；
S3. skin conditioning agent, beta glucan, panthenol and preservative are mixed evenly, obtain C phase；
S4. C phase is mixed with B, stirs 28-32min, stirs evenly, be cooled to room temperature；
Wherein,
The moisturizer is selected from one of glycerol and 1,2- pentanediol or a variety of；
The antioxidant is selected from one of tocopherol and ubiquinone or a variety of；
The skin conditioning agent is selected from one of tranexamic acid and purslane extract or a variety of；
The thickener is selected from polyacrylate cross-linked polymer -6, the tert-butyl alcohol and ammonium acryloyldime-thyltaurate/VP copolymerization
One of object is a variety of；
The preservative is selected from one of methyl esters and Phenoxyethanol or a variety of.
8. a kind of skin-protection product, wherein the skin-protection product includes moisturizing composition described in any one of claims 1-6.
9. a kind of pharmaceutical composition, wherein described pharmaceutical composition includes safe and effective amount such as any one of claim 1-6 institute
The moisturizing composition stated.
10. moisturizing composition described in any one of claims 1-6 is preparing the purposes in skin-protection product or pharmaceutical composition.
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