CN109998941A - Anti-apolexis composition, anti-ageing face mask and preparation method thereof - Google Patents
Anti-apolexis composition, anti-ageing face mask and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to a kind of anti-apolexis composition, anti-ageing face mask and preparation method thereof, which includes following components: hydrolysis Scleroglucan, glycosylglycerol, alpha-arbutin, oligopeptides -1 and cannabidiol.Anti-apolexis composition of the invention have stronger anti-aging effects, and can deep layer improve skin, enhance the effect of elasticity of skin.
Description
Technical field
The present invention relates to technical field of daily necessities, in particular to anti-apolexis composition, anti-ageing face mask and preparation method thereof.
Background technique
With the variation of people's aesthetic consciousness, more and more people pay close attention to skin care, especially women, the quality of skin
At an important indicator of ocular estimate, the use of skin care item is also at a kind of living habit of most people, and people couple
The requirement of daily necessities effect is also higher and higher, does not require nothing more than skin care item merely with moisture-keeping functions, it is also desirable to which it has preferable
Antiageing effect, with delay skin caused by external environment and age relaxation, the generation of wrinkle etc..
Currently, the anti-aging of skin care item is mainly to make the regeneration of skin and degenerate to balance to reach a kind of normal state, into
And improve skin wrinkle situation.But although there are preferable moisturizing effects compared with multi-product currently on the market, anti-wrinkle effect is unknown
It is aobvious, and water lock effect is poor.
Summary of the invention
Based on this, it is necessary to provide a kind of anti-apolexis composition, anti-ageing face mask and preparation method thereof.Of the invention is anti-ageing
Old composition have stronger anti-aging effects, and can deep layer improve skin, enhance the effect of elasticity of skin.
A kind of anti-apolexis composition, including following components: hydrolysis Scleroglucan, glycosylglycerol, alpha-arbutin, oligopeptides -1
And cannabidiol.
In one embodiment, in the anti-apolexis composition, in parts by weight, the hydrolysis Scleroglucan is
0.1-3 parts, the glycosylglycerol is 1-5 parts, and the alpha-arbutin is 0.1-2 parts, and the oligopeptides -1 is 0.1-2 parts, described
Cannabidiol is 0.5-5 parts.
In one embodiment, the mass ratio of the oligopeptides -1 and the cannabidiol is 2:(2.5-3.5).
Above-mentioned anti-apolexis composition is preparing the application in skin care item.
It can in acceptable auxiliary material and skin care item in a kind of anti-ageing face mask, including above-mentioned anti-apolexis composition, skin care item
The solvent of receiving.
In one embodiment, in the anti-ageing face mask, in terms of mass percentage, the anti-apolexis composition
For 1.5%-15%, the auxiliary material is 0.05%-8%, and the solvent is 77%-98.45%.
In one embodiment, the auxiliary material includes moisturizer, preservative, solubilizer and odorant, and described anti-
In aging facial mask, in terms of mass percentage, the moisturizer is 0.03%-5%, and the preservative is 0.2%-0.6%, institute
Stating solubilizer is 0.05%-0.3%, and the odorant is 0.01%-0.1%.
In one embodiment, the moisturizer is one of Sodium Hyaluronate and glycerol or a variety of；And/or
The preservative is Phenoxyethanol；And/or
The solubilizer is Cremophor RH40；And/or
The odorant is essence.
The preparation method of above-mentioned anti-ageing face mask, comprising the following steps:
The anti-apolexis composition, the auxiliary material and the solvent are mixed, the anti-ageing face mask is made.
In one embodiment, include by the step of anti-apolexis composition, the auxiliary material and the solvent mixing
Following steps:
The hydrolysis Scleroglucan, the glycosylglycerol, the moisturizer and water are mixed, in 70 DEG C -75 DEG C of item
It is stirred under part；
60 DEG C -65 DEG C are cooled to, and the alpha-arbutin is added, is uniformly mixed；
41 DEG C -50 DEG C are cooled to, and the oligopeptides -1 and the cannabidiol is added, is uniformly mixed；
25 DEG C -40 DEG C are cooled to, and the preservative, the solubilizer and the odorant is added, is uniformly mixed.
Each component can be absorbed well by skin in above-mentioned anti-apolexis composition, so guarantee each component itself
Curative effect, and above-mentioned anti-apolexis composition is increased by the effect of hydrolysis Scleroglucan, glycosylglycerol, alpha-arbutin and oligopeptides -1
Strong cell water content improves cell metabolism effect, enhances cytothesis ability, and using cannabidiol as inoxidizability
Substance reduces intracellular free radicals level, DNA damage caused by avoiding free radical from accumulating, and then can maintain healthy cell
Vigor, achieve the purpose that profound to improve skin.
In addition, above-mentioned anti-apolexis composition can alleviate skin inflammation, calm skin improves skin-nourishing metabolism, especially
It is the improvement for problem flesh with more apparent effect, protective barrier can be formed in skin surface, retain skin water
Divide, moisture is prevented to be lost through epidermis, and then skin is made not feel drying after, increases gloss.
And above-mentioned anti-apolexis composition each component has no toxic side effect without being cosmetics safety raw material, be not easy to produce according to
Patience is suitable for extensive production application.
Detailed description of the invention
Fig. 1 be use embodiment 2, comparative example 1- comparative example 3 anti-ageing face mask after skin moisture changes of contents curve
Figure；
A is the dermatoglyph figure using test position before embodiment 2 in Fig. 2, and b is to use test position after embodiment 2
Dermatoglyph figure.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
The anti-apolexis composition of an embodiment of the present invention, including following components: hydrolysis Scleroglucan, glycosylglycerol,
Alpha-arbutin, oligopeptides -1 and cannabidiol.
Wherein, cannabidiol is one of the 113 kinds of cannboids found in cannabis plants at present, is different from tetrahydro hemp
Phenol, it is no to cause unreal, habituation effect.Studies have shown that cannabidiol have certain antidepressant effect, can be used for alleviating depression,
Sleep disturbance, etc. symptoms, and the drug of the child's epilepsy disease of in June, 2018 cannabidiol is ratified by FDA, clinical effectiveness compared with
It is good, cannabidiol safety with higher.Currently, studies have shown that there is cannabidiol stronger anti-oxidant, anti-aging to make
With phenomena such as and capable of having and inhibit lipid, anti-inflammatory and other effects, and dry skin can also be alleviated.
Hydrolysis Scleroglucan is a kind of new non-ionic type biological polyoses polymer for having fungi pyrenomycetes to generate, the Portugal Ji Ying
Glycan, mainly by D- glucopyanosyl and α, β, 1-6 key connection, with microbe species and growth conditions difference, structure
Slightly difference, it is understood that all fall in the scope of protection of the present invention.Hydrolysis Scleroglucan can effectively penetrate into cell, increase
Add cell water content, while cell moisture loss can be prevented, guarantees the water lock ability of above-mentioned anti-apolexis composition.In addition, should
Component and biology or silk mask have good compatibility, enable skin soft comfortable, do not drip, not sticky, and its infiltration leaching
Stain cuticula makes skin with more transparency and moist sense.
Glycosylglycerol is a kind of substance combined by glycerol and glucose glycan molecule with glycosidic bond, is distributed in human body skin corium
Aquaporin (Aquaporin) be mainly AQP3.AQP3 is mainly expressed in skin base layer, the cutin in skin corium
Cell Proliferation.Glycerol channel albumen principally falls into AQP3.The mouse test for knocking out AQP3 gene shows that the skin moisture of mouse subtracts
It less and lacks flexibility, main cause is the ability for weakening glycerol and transporting from blood to epidermis, so that the concentration of epidermis glycerol drops
It is low as a result, because glycerol is the important component for maintaining skin moisture-keeping and elasticity.The reduction of glycerol concentration also weakens table simultaneously
The proliferation of skin, because glycerol is the generation of epidermal cell metabolism ATP and the important component of memebrane protein lipid synthesis.Studies have shown that
Glycosylglycerol can increase the expression of AQP3 in horn cell, activation aquaporin, and then reduce skin moisture and be lost, deep
Layer moisturizing skin, enables skin full of elasticity, further tender.In addition, showing that the IC50 of glycosylglycerol is in cell toxicity test
6.3%, HET-CAM test also indicate that glycosylglycerol to skin without any injury, the values of 5% glycosylglycerol solution is
0, glycosylglycerol is to eyes without any injury.
Alpha-arbutin is extracted from the leaf of black bearberry, some fruit and other plants it has also been discovered that the presence of Arbutin,
It has effects that make skin bright, can rapidly penetrate into skin without influencing skin cell, and it is with stronger tyrosine
Enzyme inhibition activity, combines with the Tyrosine for causing melanin to generate, effectively block Tyrosine (tyrosinase) it is movable with
And the generation of Mai Laning (melanin), accelerate the decomposition and exclusion of Mai Laning.And research shows that alpha-arbutin whitening effect
It is -10 times or so of arbutin, meanwhile, for opposite β-arbutin, alpha-arbutin more efficient stable.
Oligopeptides -1 is the synthetic peptide being made of three kinds of glycine, histidine and lysine amino acid, in being embodied in "
Use cosmetic material Names Catalogue " (version in 2015), belong to and meets Chinese law and regulations component.It can effectively promote epidermis again
It is raw, the synthesis of skin collagen is stimulated, skin barrier is repaired, remolds the biochemical function of skin, so that skin tightness is improved,
Have the function that crease-resistant and anti-aging.
Each component can be absorbed well by skin in above-mentioned anti-apolexis composition, so guarantee each component itself
Curative effect, and above-mentioned anti-apolexis composition is increased by the effect of hydrolysis Scleroglucan, glycosylglycerol, alpha-arbutin and oligopeptides -1
Strong cell water content improves cell metabolism effect, enhances cytothesis ability, and using cannabidiol as inoxidizability
Substance reduces intracellular free radicals level, DNA damage caused by avoiding free radical from accumulating, and then can maintain healthy cell
Vigor, achieve the purpose that profound to improve skin.
In addition, above-mentioned anti-apolexis composition can alleviate skin inflammation, calm skin improves skin-nourishing metabolism, especially
It is the improvement for problem flesh with more apparent effect, protective barrier can be formed in skin surface, retain skin water
Point, prevent moisture from being lost through epidermis, and then skin is made not feel drying after, increases gloss, and its also have it is certain
White-skinned face function.
And above-mentioned anti-apolexis composition each component has no toxic side effect without being cosmetics safety raw material, be not easy to produce according to
Patience is suitable for extensive production application.
Intelligible, above-mentioned each component is marketable material, according to the difference such as production firm, production batch, as long as
Its main active component is each component of above-mentioned anti-apolexis composition.
In one embodiment, in anti-apolexis composition, in parts by weight, the hydrolysis Scleroglucan is 0.1-3 parts, institute
Stating glycosylglycerol is 1-5 parts, and the alpha-arbutin is 0.1-2 parts, and the oligopeptides -1 is 0.1-2 parts, and the cannabidiol is
0.5-5 parts.
In one embodiment, in anti-apolexis composition, in parts by weight, the hydrolysis Scleroglucan is 0.2-1 parts, institute
Stating glycosylglycerol is 1.5-3.5 parts, and the alpha-arbutin is 0.2-1 parts, and the oligopeptides -1 is 0.5-2 parts, the hemp two
Phenol is 1-4 parts.
In one embodiment, the mass ratio of oligopeptides -1 and cannabidiol is 2:(2.5-3.5).
Within the above range by each component control of each anti-apolexis composition, better synergistic effect can be obtained, is promoted
The anti-aging effects of anti-apolexis composition.
Since above-mentioned anti-apolexis composition has preferable anti-aging, moisturizing, white-skinned face function, and it being capable of deep layer improvement flesh
Skin enhances elasticity of skin, therefore above-mentioned anti-apolexis composition is suitable for skin care item processed, such as: water, cream, frost, facial mask, foundation cream etc.,
It is not specially limited herein.
The preparation method of the anti-apolexis composition of an embodiment of the present invention, comprising the following steps: by anti-apolexis composition
Each component be uniformly mixed, wherein anti-apolexis composition include hydrolysis Scleroglucan, glycosylglycerol, alpha-arbutin, oligopeptides -1
And cannabidiol.Each component effect and its content are same as described above, and details are not described herein.
It is acceptable auxiliary in the anti-ageing face mask of an embodiment of the present invention, including above-mentioned anti-apolexis composition, skin care item
Acceptable solvent in material and skin care item.The component and its content effect of above-mentioned anti-apolexis composition are as described above, herein no longer
It repeats.
Wherein, auxiliary material can be understood as the acceptable customary adjuvant in this field, be not specially limited herein.According to facial mask shape
The difference of state can choose suitable auxiliary material.In one embodiment, auxiliary material includes moisturizer, preservative, solubilizer and assigns fragrant
Agent.Solvent can be subjected to Conventional solvents for this field, such as ethyl alcohol etc. is subjected in deionized water, skin care item.
Wherein, moisturizer includes but is not limited to one of Sodium Hyaluronate and glycerol or a variety of.Sodium Hyaluronate is also known as
Sodium hyaluronate sodium belongs to skin conditioner, is a kind of acid mucopolysaccharide, is naturally present in cornea skin, can absorb itself weight
1000 times of moisture are lost by retaining moisture of skin, prevention moisture through epidermis with reaching, and the screen when skin is damaged
Barrier is repaired, and skin is enabled not feel drying after, increases gloss, it can improve skin-nourishing metabolism, makes that skin is soft, light
It slides, goes wrinkle, increase elasticity, prevent aging, be good skin penetration enhancer again while moisturizing.With other nutritional ingredients
It is used cooperatively, the more preferable effect for promoting nutrient absorption can be played.
Glycerol has stronger moisture retention, and it can absorb the moisture in air, play the role of permanent moisturizing, especially
It is the glycosylglycerol in above-mentioned anti-apolexis composition, has the function of increasing AQP3 expression in spongiocyte, be glycerol
Channel can promote the absorption of glycerol under the action of glycosylglycerol, further enhance the shrink ability of skin, enhance flesh
Skin elasticity.
Preservative can be Phenoxyethanol, and solubilizer can be Cremophor RH40, and odorant can be essence.Its
In, Phenoxyethanol as preservative n-compound, generally will not release formaldehyde, toxicology data shows LD50 (median lethal
Amount): rat oral: 3000mg/kg, mouse oral: 4000mg/kg.Belonging to mild toxicity, (data source is in " cosmetics anti-corrosion
The current situation and development of agent " 2007 editions), therefore there is preferable safety.
Essence, the oily matters such as essential oil can be evenly dispersed into water by Cremophor RH40, formed and stablized, thoroughly
Bright solution, and the component raw material derives from natural plants, it can be biodegradable, therefore have no toxic side effect, safely and effectively.
It should be noted that the additive amount of auxiliary material can according to need appropriate adjustment in the reasonable scope.In an embodiment
In, in anti-ageing face mask, in terms of mass percentage, moisturizer 0.03%-5%, solubilizer 0.05%-0.3% are assigned
Pastil is 0.01%-0.1%.
On the one hand above-mentioned anti-ageing face mask promotes each active group in above-mentioned anti-apolexis composition by selecting suitable auxiliary material
The absorption divided, enhances the effect of each component, improves the anti-aging effects of anti-ageing face mask；On the other hand, excipient itself can be with
Each active component mutually acts synergistically in above-mentioned anti-apolexis composition, further enhances the effect of active component, improves anti-aging
The effect of facial mask.In addition, each component is green safe in above-mentioned anti-ageing face mask, have no toxic side effect, is not easy sensitization, and can also change
Kind skin quality, enhancing skin resist environment capacity.
An embodiment of the present invention additionally provides the preparation method of above-mentioned anti-ageing face mask, comprising the following steps: will be above-mentioned
Anti-apolexis composition, auxiliary material and solvent mixing, stir evenly, specifically:
S101: hydrolysis Scleroglucan, glycosylglycerol, moisturizer and water are mixed, carried out under conditions of 70 DEG C -75 DEG C
Stirring.
The order of addition of each material is not particularly limited in step S101, emulsion pot first can be added in deionized water, is opened
It stirs at low speed, is then slowly added into hydrolysis Scleroglucan and adds glycosylglycerol and moisturizer after homogeneous 1-3 minutes, while stirring
It mixes side and is warming up to 70 DEG C -75 DEG C, enter in next step until being completely dispersed and uniformly starting cooling.
S102: being cooled to 60 DEG C -65 DEG C, and alpha-arbutin be added, and is uniformly mixed.
Alpha-arbutin directly can be added into the emulsion pot of step S101 in step S102, it can also be first by alpha-arbutin
It is dispersed in certain water, then adds in the emulsion pot of step S101, stir.
Additionally, it is preferred that alpha-arbutin is then added after being first cooled to 60 DEG C -65 DEG C, it can so guarantee alpha-arbutin energy
While enough fully dispersed, activity is reduced caused by avoiding because of high temperature.
S103: being cooled to 41 DEG C -50 DEG C, and oligopeptides -1 and cannabidiol be added, and is uniformly mixed.
The order of addition of oligopeptides -1 and cannabidiol is not particularly limited in step S103, and preferred first near required temperature,
Oligopeptides -1 and cannabidiol are added again.
S104: being cooled to 25 DEG C -40 DEG C, and preservative, solubilizer and odorant is added, and is uniformly mixed.
In step S104, the preservative added in advance, solubilizer and odorant can be dispersed in certain deionized water, so
After be then added in emulsion pot.And it is preferably first cooled to required temperature, add preservative, solubilizer, odorant.
S105: sampling, detection after qualified, are filtered, discharging.
In above-mentioned steps, sample detection method can use conventional method in that art, be not specially limited herein.
The preparation method of above-mentioned anti-ageing face mask rationally controls addition temperature using the property of each component, made in guarantee
While the physical property of the facial mask obtained, the activity of retentive activity component, has obtained anti-ageing face mask to greatest extent
Preferable effect.And above-mentioned preparation method is easy to operate, is not necessarily to special instruments and equipment, is suitable for industrial production application.
Specific embodiment is set forth below, and the present invention will be described.
It should be noted that do not indicate the instrument of production firm in following example and reagent be commercially available conventional instrument and
Reagent.
Embodiment 1
The component and its content of anti-apolexis composition are referring to table 1
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.1%, glycerol 0.5%, deionized water surplus.
Preparation method:
(1) deionized water is added in emulsion pot, it is under low speed homogeneous, hydrolysis Scleroglucan, Sodium Hyaluronate is slow
It is spilled into emulsion pot, after homogeneous 1-3 minutes, glycerol glucose aldehyde and glycerol is added, heating is heated to 70-75 DEG C, directly while stirring
Uniformly start to cool down to being completely dispersed；
(2) it is cooled to 60-65 DEG C, pre-dispersed good alpha-arbutin material is added, is stirred；
(3) 41 DEG C -50 DEG C are cooled to, oligopeptides -1 and cannabidiol are sequentially added, is stirred；
(4) 39 DEG C -40 DEG C are cooled to, pre-dispersed Phenoxyethanol, essence and Cremophor RH40 is added；
(5) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge.
Table 1 (parts by weight)
(hydrolysis Scleroglucan production firm: GIGA Bio-Tech Development Int.LTD)
Embodiment 2
The component and its content of anti-apolexis composition are referring to table 1
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.1%, glycerol 0.5%, deionized water surplus.
Preparation method: with embodiment 1
Embodiment 3
The component and its content of anti-apolexis composition are referring to table 1
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.1%, glycerol 1%, deionized water surplus.
Preparation method: with embodiment 1
Embodiment 4
The component and its content of anti-apolexis composition are referring to table 1
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.2%, glycerol 0.5%, deionized water surplus.
Preparation method: with embodiment 1
Embodiment 5
The component and its content of anti-apolexis composition are referring to table 1
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.05%, glycerol 0.5%, deionized water surplus.
Preparation method: with embodiment 1
Comparative example 1
The component and its content of anti-apolexis composition are referring to table 2
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.1%, glycerol 0.5%, deionized water surplus.
Preparation method: substantially with embodiment 2, the difference is that, do not add cannabidiol.
Table 2 (parts by weight)
Comparative example 2
The component and its content of anti-apolexis composition are referring to table 2
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.1%, glycerol 0.5%, deionized water surplus.
Preparation method: substantially with embodiment 1, the difference is that, do not add glycosylglycerol.
Comparative example 3
The component and its content of anti-apolexis composition are referring to table 2
Anti-ageing face mask, in terms of mass percentage: anti-apolexis composition 7.5%, Phenoxyethanol 0.3%, essence
0.05%, Cremophor RH40 0.15%, Sodium Hyaluronate 0.1%, glycerol 0.5%, deionized water surplus.
Preparation method: substantially with embodiment 1, the difference is that, hydrolysis Scleroglucan is not added.
Compliance test result experiment
One, in vitro test
(1) free radical scavenging activity is tested
Sample to be tested: embodiment 1- embodiment 5, the anti-apolexis composition of comparative example 1- comparative example 3；
Reagent: 1,1- diphenyl -2- trinitrophenyl-hydrazine (DPPH), dehydrated alcohol；
Sample to be tested is prepared: the anti-apolexis composition of 20mg embodiment 1- embodiment 5, comparative example 1- comparative example 3 is taken respectively,
250mL is dissolved and is settled to dehydrated alcohol, it is spare；
The preparation of DPPH: accurately weighing 20mg DPPH, and 250mL is dissolved and be settled to dehydrated alcohol, spare；
Instrument: ultra-violet and visible spectrophotometer, insulating box；
Method: the sample to be tested and 2mL DPPH solution by 2mL through preformulation are as having in the test tube sieved, as insulating box
In at 37 DEG C constant temperature 1h using dehydrated alcohol as blank control the absorbance A of each sample to be tested is measured at 517nmi, and press
Formula calculates clearance rate:
Clearance rate=[1- (Ai-Aj)/Ac] × 100%
Wherein, Ac: 2ml dehydrated alcohol adds the absorbance of 2mL DPPH solution；
Ai: 2mL test agent adds the absorbance of 2mL DPPH solution；
Aj: 2mL test agent adds the absorbance of 2mL ethanol solution；
Each sample to be tested surveys three groups of Duplicate Samples, averages, as a result as shown in the table
Table 2
From table 2 it can be seen that the anti-apolexis composition of embodiment 1- embodiment 5 has preferably free radical scavenging activity.It is right
The anti-apolexis composition of ratio 1- comparative example 3 has certain radicals scavenging effect, but is obviously not so good as embodiment 1- embodiment
5, especially comparative example 1, compared to other anti-apolexis compositions, radicals scavenging effect, which has, to be decreased obviously, and illustrates hemp two
Phenol plays an important role the radicals scavenging effect of anti-apolexis composition.
(2) promote the detection of soluble collagen secretion
Human fibroblasts will be cultivated in the DMEM culture medium containing 10%FBS, and is seeded on 48 orifice plates, cell attachment
Afterwards, culture medium exchange is carried out with the DMEM culture medium containing 0.25%FBS and magnesium ascorbyl phosphate, embodiment 1- is added and implements
The anti-apolexis composition of example 5 and comparative example 1- comparative example 3.After cultivating 72h, medium supernatant is recycled, is centrifugated, is surveyed
The content of soluble collagen in fixed gained supernatant.As a result such as table 3.
Table 3
From table 3 it can be seen that the rush soluble collagen secretion of the anti-apolexis composition of embodiment 1- embodiment 5
It is substantially better than comparative example 1- comparative example 3.Therefore the anti-apolexis composition of embodiment 1- embodiment 5 is suitable for that skin care item are made, for promoting
Into the secretion of collagen, makes the regeneration of skin and balance of degenerating reaches a kind of preferably state.
Two, clinical test
(1) degree and water lock test are moistened
Test equipment: Corneometer CM825
Experimental situation: 25 DEG C 25 DEG C, humidity 5025%, and real-time dynamic monitoring
Tester: Liu, women, 32 years old
Test method: taking inboard arm skin, and left and right takes the region of two area equations respectively, totally four regions, respectively
Using the product of embodiment 2 and comparative example 1- comparative example 3, and test the water using 0h, 30min, 1h, 3h, 6h, 12h after product
Divide content, do not use other skin-protection products during the whole test, without movement, is in isoperibol, test result is such as
Table 3, curvilinear motion such as Fig. 1.In Fig. 2 a be using test position before embodiment 2 dermatoglyph figure, b be using embodiment 2 after
The dermatoglyph figure of test position.
Table 4
From table 4, it can be seen that the facial mask of embodiment 2, comparative example 1- comparative example 3 all has preferable moisturizing effects.From Fig. 1
As can be seen that the long-acting moisture-keeping function of embodiment 2 is substantially better than comparative example 1- comparative example 3, illustrate the anti-ageing face mask of embodiment 2
With preferably water lock effect.
Figure it is seen that skin roughness also has a degree of improvement after anti-ageing face mask using embodiment 2,
Illustrate that above-mentioned anti-ageing face mask can enhance the moist sense and transparency of skin.
(2) anti-aging is tested
1. patch test:
Tester: volunteer 80, the age was at 28-60 years old；Volunteer is divided into 4 groups, every group 20, is tested respectively
State the anti-ageing face mask of embodiment 2 and comparative example 1- comparative example 3；
Inclusion criteria: dry skin, elasticity reduces, occurs that wrinkle, the colour of skin are dark yellow etc. to have the volunteer of skin, but
No any skin and systemic disease suffer from history, and hormone medicine is not used in nearly one month；
Product uses rule: during testing first 2-3 days and entirely test, being changed without skin care item, and do not use any hormone
Class drug uses 1 time for two days.
The patch test of embodiment 2, comparative example 1- comparative example 3 is carried out to volunteer 80, wherein table 5 indicates that skin is bad
React grade scale, test result such as table 6.
Table 5 is skin adverse reaction grading standard
6 patch test results of table
Test group all has no adverse reaction, and can carry out follow-up test.
2. skin wrinkle improves situation；
Instrument: VISA face-image analysis system
Test method: being tested by standard of crow's feet, takes the skin of same area when test as far as possible every time, when test
Loosen.Comparison improves situation before and using wrinkle after one month, three months, and each region is surveyed 3 times every time, is averaged.
Evaluation criteria:
10 points, without wrinkle；
7-9 points, there is 2-3 wrinkle, length is less than 1.5cm；
4-6 points, there is 3-6 wrinkle, length is less than 3cm；
1-3 points, there are several main wrinkles, length is greater than 4cm, is also accompanied by shallow wrinkle.
Test result is as follows table 7
As can be seen from Table 7, the wrinkle remission effect of embodiment 2 is better than comparative example 1- comparative example 3.Comparative example 1 and implementation
Example 2 is essentially identical, the difference is that comparative example 1 does not contain cannabidiol, as can be seen from Table 7, the anti-aging of comparative example 1 is made
With embodiment 2, especially permanence operation is obviously not so good as, illustrate cannabidiol for the anti-ageing of anti-ageing face mask of the invention
Effect plays a significant role.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of anti-apolexis composition, which is characterized in that including following components: hydrolysis Scleroglucan, glycosylglycerol, α-black bearberry
Glycosides, oligopeptides -1 and cannabidiol.
2. anti-apolexis composition according to claim 1, which is characterized in that in the anti-apolexis composition, with weight
Part meter, the hydrolysis Scleroglucan are 0.1-3 parts, and the glycosylglycerol is 1-5 parts, and the alpha-arbutin is 0.1-2 parts, institute
Stating oligopeptides -1 is 0.1-2 parts, and the cannabidiol is 0.5-5 parts.
3. anti-apolexis composition according to claim 2, which is characterized in that the matter of the oligopeptides -1 and the cannabidiol
Amount is than being 2:(2.5-3.5).
4. the described in any item anti-apolexis compositions of claim 1-3 are preparing the application in skin care item.
5. a kind of anti-ageing face mask, which is characterized in that including the described in any item anti-apolexis compositions of claim 1-3, skin care
Acceptable solvent in acceptable auxiliary material and skin care item in product.
6. according to right want 5 described in anti-ageing face mask, which is characterized in that in the anti-ageing face mask, contained with quality percentage
Meter, the anti-apolexis composition are 1.5%-15%, and the auxiliary material is 0.05%-8%, and the solvent is 77%-
98.45%.
7. anti-ageing face mask according to claim 6, which is characterized in that the auxiliary material includes moisturizer, preservative, solubilising
Agent and odorant, and in the anti-ageing face mask, in terms of mass percentage, the moisturizer is 0.03%-5%, described
Preservative is 0.2%-0.6%, and the solubilizer is 0.05%-0.3%, and the odorant is 0.01%-0.1%.
8. anti-ageing face mask according to claim 7, which is characterized in that the moisturizer is in Sodium Hyaluronate and glycerol
It is one or more；And/or
The preservative is Phenoxyethanol；And/or
The solubilizer is Cremophor RH40；And/or
The odorant is essence.
9. the preparation method of the described in any item anti-ageing face masks of claim 5-8, which comprises the following steps:
The anti-apolexis composition, the auxiliary material and the solvent are mixed, the anti-ageing face mask is made.
10. the preparation method of anti-ageing face mask according to claim 9, which is characterized in that by the anti-apolexis composition,
The step of auxiliary material and the solvent mix the following steps are included:
The hydrolysis Scleroglucan, the glycosylglycerol, the moisturizer and water are mixed, under conditions of 70 DEG C -75 DEG C
It is stirred；
60 DEG C -65 DEG C are cooled to, and the alpha-arbutin is added, is uniformly mixed；
41 DEG C -50 DEG C are cooled to, and the oligopeptides -1 and the cannabidiol is added, is uniformly mixed；
25 DEG C -40 DEG C are cooled to, and the preservative, the solubilizer and the odorant is added, is uniformly mixed.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111700814A (en) * | 2020-07-16 | 2020-09-25 | 深圳市美瑞健康科技有限公司 | Soothing and repairing mask containing cannabis sativa leaf extract and preparation method of soothing and repairing mask |
| CN115363994A (en) * | 2022-10-09 | 2022-11-22 | 何燕兰 | Skin care product for whitening and removing freckles and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619078A (en) * | 2018-08-20 | 2018-10-09 | 广州无添加主义化妆品有限公司 | A kind of whitening skin lightening facial mask and preparation method thereof |
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2019
- 2019-04-26 CN CN201910342514.8A patent/CN109998941A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619078A (en) * | 2018-08-20 | 2018-10-09 | 广州无添加主义化妆品有限公司 | A kind of whitening skin lightening facial mask and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111700814A (en) * | 2020-07-16 | 2020-09-25 | 深圳市美瑞健康科技有限公司 | Soothing and repairing mask containing cannabis sativa leaf extract and preparation method of soothing and repairing mask |
| CN115363994A (en) * | 2022-10-09 | 2022-11-22 | 何燕兰 | Skin care product for whitening and removing freckles and preparation method thereof |
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