CN109998939A - Crease-resistant Firm composition, crease-resistant Firm Essence and preparation method thereof - Google Patents
Crease-resistant Firm composition, crease-resistant Firm Essence and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to a kind of crease-resistant Firm compositions, crease-resistant Firm Essence and preparation method thereof, wherein crease-resistant Firm composition includes following components: -7 0.05-3 parts of palmityl tetrapeptide, -1 0.5-8 parts of palmityl tripeptides, 0.1-3 parts of fibronectin, 0.1-6 parts of cannabidiol.Above-mentioned crease-resistant Firm composition is interacted by each component, inhibit the inflammatory reaction of skin, and then reduce cell senescence apoptosis speed, sufficient nutriment is provided at the same time for skin, improve cytotrophy metabolism, moisturizing promotes cytothesis, to maintain the regeneration of cell and balance of degenerating, keep skin health vibrant.And above-mentioned crease-resistant Firm composition has stronger free radical inhibiting effect, further maintains cellular homeostasis, improves cytothesis ability, improves crease-resistant skin tightening effect.
Description
Technical field
The present invention relates to technical field of daily necessities, in particular to crease-resistant Firm composition, crease-resistant Firm Essence and its system
Preparation Method.
Background technique
Skin is covered on human body surface, directly contacts with external environment, is influenced by diversified factor, it is easy to meet with
To damage, one of feature the most apparent is exactly skin relaxation, wrinkle appearance, pigmentation etc..Lead to the most main of skin relaxation
It wants the reason is that since undermost dermal tissue loses elasticity.There is osseins and elastic fibrous tissue fiber in corium, but this
A little fibers can change with advancing age, reduce texture.In addition, cell-fiber of manufacture ossein and elastic fibrous tissue
The reduced activity of sprout cell cannot regenerate new elastomer, and it is powerless that skin can become relaxation naturally.Initial stage pore starts to expand
, skin follow the string, face mask may be changed to stage.
There is also more anti-wrinkle products currently on the market, mainly resist skin aging using the mechanism of free radical resisting,
It is relatively broad using the products material of the mechanism, containing the reducing substances of free radical resisting in most plants extract, and
Usual plant extracts also has the effects that be able to ascend the resultant effect of product, but such product is crease-resistant such as moisturizing whitening
Effect is poor, is unable to satisfy numerous Man's Demands.
Summary of the invention
Based on this, it is necessary to provide a kind of safely and efficiently crease-resistant Firm composition, crease-resistant Firm Essence and its preparation
Method.
A kind of crease-resistant Firm composition, in parts by weight, the crease-resistant Firm composition includes following components:
In one embodiment, in the crease-resistant Firm composition, the palmityl tetrapeptide -7 is 0.1-2 parts, institute
Stating palmityl tripeptides -1 is 1-5 parts, and the fibronectin is 0.1-2 parts, and the cannabidiol is 0.5-5 parts.
In one embodiment, the palmityl tetrapeptide -7 and the mass ratio of the palmityl tripeptides -1 are 1:(5-6)；
And/or
The mass ratio of the fibronectin and the cannabidiol are as follows: 2:(2.5-3.5).
Above-mentioned crease-resistant Firm composition is preparing the application in skin care item.
Acceptable auxiliary material and skin care on a kind of crease-resistant Firm Essence, including above-mentioned crease-resistant Firm composition, skin care item
Acceptable solvent on product.
In one embodiment, in the crease-resistant Firm Essence, in terms of mass percentage, the crease-resistant Firm
Composition is 1.2%-14%, and the auxiliary material is 0.3%-3%, and the solvent is 83%-98.5%.
In one embodiment, the auxiliary material includes moisturizer, thickener, solubilizer, preservative and odorant, and
In the crease-resistant Firm Essence, in terms of mass percentage, the moisturizer is 0.03%-0.2%, and the thickener is
0.01%-0.5%, the solubilizer are 0.05%-0.3%, and the preservative is 0.2%-0.6%, and the odorant is
0.01%-0.1%.
In one embodiment, the moisturizer is Sodium Hyaluronate；And/or
The thickener is xanthan gum；And/or
The solubilizer is Cremophor RH40；And/or
The preservative is Phenoxyethanol；And/or
The odorant is essence.
The preparation method of above-mentioned crease-resistant Firm Essence, comprising the following steps:
The crease-resistant Firm composition, the auxiliary material and the solvent are mixed, the crease-resistant Firm Essence is made.
In one embodiment, the step of crease-resistant Firm composition, the auxiliary material and the solvent being mixed is wrapped
Include following steps:
The thickener, the moisturizer and the solvent are mixed, are stirred under conditions of 70 DEG C -75 DEG C；
50 DEG C -55 DEG C are cooled to, and the palmityl tetrapeptide -7 and the palmityl tripeptides -1 are added, is uniformly mixed；
41 DEG C -45 DEG C are cooled to, and the fibronectin and the cannabidiol is added, is uniformly mixed；
25 DEG C -40 DEG C are cooled to, and the preservative, the solubilizer and the odorant is added, is uniformly mixed.
Above-mentioned crease-resistant Firm composition is by selecting palmityl tetrapeptide -7, palmityl tripeptides -1, fibronectin and hemp two
Phenol mixes in proper proportions, so that each component interacts, inhibits the inflammatory reaction of skin, and then reduce cell senescence apoptosis
Speed provides sufficient nutriment at the same time for skin, improves cytotrophy metabolism, and moisturizing promotes cytothesis,
To maintain the regeneration of cell and balance of degenerating, keep skin health vibrant.And above-mentioned crease-resistant Firm composition have it is stronger from
By base inhibiting effect, cellular homeostasis is further maintained, improves cytothesis ability, improves crease-resistant skin tightening effect.
Above-mentioned crease-resistant Firm composition can form protective barrier in skin surface, retain moisture of skin, moisture is prevented to pass through
Epidermis is lost, and then skin is made not feel drying after, increases gloss.And above-mentioned crease-resistant Firm composition each component is without equal
It for cosmetics safety raw material, has no toxic side effect, is not easy to produce accordance with tolerance, be suitable for extensive production application.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
The crease-resistant Firm composition of an embodiment of the present invention, in parts by weight, including following components:
Wherein, palmityl tetrapeptide -7 is a kind of polypeptide, is the segment of immunoglobulin lgG, and there are many bioactivity function
Energy, especially immune function.Palmityl tetrapeptide -7 is made by stimulation Laminin lens (LamininV) IV, VII collagen type
Skin consolidation, delays and inhibits the production of excessive cell interleukin, thus inhibit some unnecessary inappropriate inflammatory reactions and
Glycosylation damage, it is uneven that prevention forms wrinkle, relaxation and the colour of skin.
Palmityl tripeptides -1 are a kind of matrikine signal peptides, it acts on skin corium, can promote extracellular matrix I
Connect the synthesis of albumen with type III collagen, elastin laminin, structural glycoprotein such as Fibronectin and fiber, wound is promoted to restore
It updates and rebuilds with tissue, reinforce skin corium, so that skin is become thicker, compact, wrinkle is releived, and it is stronger to resist extraneous ability.
And palmityl tetrapeptide -7 and palmityl tripeptides -1 have stronger synergistic effect, can increase the generation of collagen, promote skin
The healing and regeneration of skin.
Fibronectin is present in the macromolecular cell outer membrane protein of many animals cell surface, is extracellular matrix and substrate
Main non-Collagen glycoprotein in film, to the compatibility of Fibroblast tool height, it is also in conjunction with collagenous fibres
Net is formed together, and fibroblast is trapped among in the net of collagen.Therefore, Fibronectin can promote cell with it is intercellular
Adhesion, the adhesion between cell and organ adjust intercellular relationship, while can restore the normal function of cell, promote cell
Division.Fibronectin can be used as treating the drug of skin numerous imbalances and the conditioner of cosmetics, while have promotion skin
The functions such as regeneration, healing of wound, skin care, stimulation hair tonic.
Cannabidiol is one of the 113 kinds of cannboids found in cannabis plants at present, is different from tetrahydrocannabinol, nothing
Cause unreal, habituation effect.Studies have shown that cannabidiol has certain antidepressant effect, it can be used for alleviating depression, sleep barrier
Hinder, etc. symptoms, and the drug of the child's epilepsy disease of in June, 2018 cannabidiol is ratified by FDA, and clinical effectiveness is preferable, greatly
Numb diphenol safety with higher.Currently, studies have shown that cannabidiol has stronger anti-inflammatory effect, can with into palm fibre
Palmitic acid acyl tetrapeptide -7 and palmityl tripeptides -1 interact, and enhance the power of regeneration of cell.And it is a kind of stronger free radical suppression
Preparation, can delaying skin aging, maintain intracellular free radicals balance.
Above-mentioned crease-resistant Firm composition is by selecting palmityl tetrapeptide -7, palmityl tripeptides -1, fibronectin and hemp two
Phenol mixes in proper proportions, so that each component interacts, inhibits the inflammatory reaction of skin, and then reduce cell senescence apoptosis
Speed provides sufficient nutriment at the same time for skin, improves cytotrophy metabolism, and moisturizing promotes cytothesis,
To maintain the regeneration of cell and balance of degenerating, keep skin health vibrant.And above-mentioned crease-resistant Firm composition have it is stronger from
By base inhibiting effect, cellular homeostasis is further maintained, improves cytothesis ability, improves crease-resistant skin tightening effect.
Above-mentioned crease-resistant Firm composition can form protective barrier in skin surface, retain moisture of skin, moisture is prevented to pass through
Epidermis is lost, and then skin is made not feel drying after, increases gloss.And above-mentioned crease-resistant Firm composition each component is without equal
It for cosmetics safety raw material, has no toxic side effect, is not easy to produce accordance with tolerance, be suitable for extensive production application.
It should be noted that each component is marketable material, production method, production firm in above-mentioned crease-resistant tightening cosmetic composition
With the difference of production batch, product quality can have a degree of difference, it is understood that in protection scope of the present invention
It is interior.
Further, in crease-resistant Firm composition, palmityl tetrapeptide -7 is 0.1-2 parts, and palmityl tripeptides -1 are 1-5
Part, fibronectin is 0.1-2 parts, and cannabidiol is 0.5-5 parts.Each component is controlled within the above range, so that each component
It mutually acts synergistically stronger, enhances crease-resistant effect of crease-resistant Firm composition.
Further, palmityl tetrapeptide -7 and the mass ratio of palmityl tripeptides -1 are 1:(5-6)；And/or fibronectin and
The mass ratio of cannabidiol is 2:(2.5-3.5).Aforementioned proportion range is controlled, the synergistic effect between component is conducive to, is promoted
Crease-resistant effect of crease-resistant Firm composition.
Since above-mentioned anti-ageing Firm composition has preferable anti-aging, moisturizing, white-skinned face function, and it being capable of deep layer improvement
Skin enhances elasticity of skin, therefore above-mentioned anti-ageing Firm composition is suitable for skin care item processed, such as: water, cream, frost, facial mask, powder
Bottom etc., is not specially limited herein.
An embodiment of the present invention additionally provides the preparation method of above-mentioned anti-apolexis composition, comprising the following steps: will resist
The each component of anti-aging composition is uniformly mixed.Mixed method and its actual conditions are not particularly limited, can according to the actual situation into
Row adjustment.
An embodiment of the present invention additionally provides a kind of crease-resistant Firm Essence, including above-mentioned crease-resistant Firm composition, shield
Acceptable solvent on auxiliary material and skin care item is subjected on skin product.The component and its content effect of above-mentioned crease-resistant Firm composition are as above
Described, details are not described herein.
Wherein, auxiliary material can be understood as the acceptable customary adjuvant in this field, be not specially limited herein.According to facial mask shape
The difference of state can choose suitable auxiliary material.In one embodiment, auxiliary material includes moisturizer, thickener, solubilizer, preservative
And odorant.Solvent can be subjected to Conventional solvents for this field, such as ethyl alcohol etc. is subjected in deionized water, skin care item.
Wherein, moisturizer includes but is not limited to Sodium Hyaluronate.Sodium Hyaluronate is also known as sodium hyaluronate sodium, belongs to skin tune
Agent is managed, is a kind of acid mucopolysaccharide, is naturally present in cornea skin, itself 1000 times of moisture of weight is can absorb, to reach logical
It crosses reservation moisture of skin, moisture is prevented to be lost through epidermis, and the barrier reparation when skin is damaged, after enabling skin use
Will not feel drying, increase gloss, it can improve skin-nourishing metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent
Aging is good skin penetration enhancer again while moisturizing.It is used cooperatively with other nutritional ingredients, promotion can be played
The more preferable effect of nutrient absorption.
Thickener can be xanthan gum, also known as xanthan gum, be a kind of natural polysaccharide and important biopolymer, be mesh
Preceding collection in the world is thickened, is suspended, emulsifying, being stable at the biogum that integrated best performance is got over.It can be used for bread, ice cream, cream
In product, meat products, jam, jelly, beverage etc., safety with higher.Therefore it can be guaranteed by addition xanthan gum made
The crease-resistant Firm Essence obtained has preferably physical behavior, has no toxic side effect simultaneously, securely and reliably.
Preservative can be Phenoxyethanol, and solubilizer can be Cremophor RH40, and odorant can be essence.Its
In, Phenoxyethanol as preservative n-compound, generally will not release formaldehyde, toxicology data shows LD50 (median lethal
Amount): rat oral: 3000mg/kg, mouse oral: 4000mg/kg.Belonging to mild toxicity, (data source is in " cosmetics anti-corrosion
The current situation and development of agent " 2007 editions), therefore there is preferable safety.
Essence, the oily matters such as essential oil can be evenly dispersed into water by Cremophor RH40, formed and stablized, thoroughly
Bright solution, and the component raw material derives from natural plants, it can be biodegradable, therefore have no toxic side effect, safely and effectively.
It should be noted that the additive amount of auxiliary material can according to need appropriate adjustment in the reasonable scope.In an embodiment
In, in crease-resistant Firm Essence, in terms of mass percentage, moisturizer 0.03%-0.2%, thickener 0.01%-
0.5%, solubilizer 0.05%-0.3%, preservative 0.2%-0.6%, odorant 0.01%-0.1%.
On the one hand above-mentioned crease-resistant Firm Essence is promoted each in above-mentioned crease-resistant Firm composition by selecting suitable auxiliary material
The absorption of active component enhances the effect of each component, improves the anti-aging effects of crease-resistant Firm Essence；On the other hand, auxiliary material
It itself can mutually act synergistically with each active component in above-mentioned crease-resistant Firm composition, further enhance the work of active component
With the effect of improving crease-resistant Firm Essence.In addition, each component is green safe in above-mentioned crease-resistant Firm Essence, nontoxic pair
Effect, is not easy sensitization, and can also improve skin quality, and enhancing skin resists environment capacity.
An embodiment of the present invention additionally provides the preparation method of above-mentioned crease-resistant Firm Essence, comprising the following steps: will
Above-mentioned crease-resistant Firm composition, accessories and solvent mixing, specifically:
S101: thickener, moisturizer and solvent are mixed, are stirred under conditions of 70 DEG C -75 DEG C；
The order of addition of each material is not particularly limited in step S101, emulsion pot first can be added in solvent, be opened low speed
Thickener and moisturizer, are then successively added into emulsion pot, are heated to 70-75 DEG C while stirring by stirring, until dividing completely
It dissipates uniformly, starts to cool down.
S102: being cooled to 50 DEG C -55 DEG C, and palmityl tetrapeptide -7 and palmityl tripeptides -1 is added, and is uniformly mixed.
Palmityl tetrapeptide -7 and palmityl tripeptides -1 can be added in step S102 directly into the emulsion pot of step S101,
Palmityl tetrapeptide -7 and palmityl tripeptides -1 can also be first dispersed in certain solvent, then add the cream of step S101
Change in pot, stirs.
Additionally, it is preferred that being first cooled to 50 DEG C -55 DEG C, the palmityl tetrapeptide -7 and palmityl three dispersed in advance is then added
Peptide -1 avoids leading because of high temperature while capable of so guaranteeing that palmityl tetrapeptide -7 and palmityl tripeptides -1 can be fully dispersed
The activity of cause reduces.
S103: 41 DEG C -45 DEG C are cooled to, and fibronectin and cannabidiol is added, is stirred evenly.
The order of addition of fibronectin and cannabidiol is not particularly limited in step S103, and preferred first near required temperature
Degree, then add fibronectin and cannabidiol.
S104: being cooled to 25 DEG C -40 DEG C, and preservative, solubilizer and odorant is added, and stirs evenly.
In step S104, the preservative added in advance, solubilizer and odorant can be dispersed in certain solvent, then again
It is added in emulsion pot.And it is preferably first cooled to required temperature, add preservative, solubilizer, odorant.
S105: sampling, detection after qualified, are filtered, discharging.
In above-mentioned steps, sample detection method can use conventional method in that art, be not specially limited herein.
The preparation method of above-mentioned crease-resistant compact Essence rationally controls addition temperature using the property of each component, is guaranteeing
While the physical property of obtained facial mask, the activity of retentive activity component, makes obtained crease-resistant compact essence to greatest extent
Magnificent liquid has preferable effect.And above-mentioned preparation method is easy to operate, is not necessarily to special instruments and equipment, is suitable for industrial production application.
Specific embodiment is set forth below, and the present invention will be described.
It should be noted that do not indicate the instrument of production firm in following example and reagent be commercially available conventional instrument and
Reagent.
Palmityl tetrapeptide -7: Zhejiang surge peptide biology Co., Ltd
Palmityl tripeptides -1: Zhejiang surge peptide biology Co., Ltd
Cannabidiol: Yunnan Han Musen Biotechnology Co., Ltd
Embodiment 1
The component and its content of crease-resistant Firm composition are referring to table 1
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method:
(1) deionized water is added in emulsion pot, under low speed homogeneous, xanthan gum, Sodium Hyaluronate is slowly spilled into cream
Change in pot, heating is heated to 70-75 DEG C while stirring, until being completely dispersed uniformly, starts to cool down.
(2) it is cooled to 50-55 DEG C, pre-dispersed good palmityl tetrapeptide -7 and palmityl tripeptides -1 are added in emulsion pot,
It stirs.
(3) 41 DEG C -45 DEG C are cooled to, fibronectin and cannabidiol are sequentially added, is stirred evenly.
(4) 40 DEG C are cooled to, emulsion pot will be added with scattered Phenoxyethanol, essence and Cremophor RH40
In, it stirs evenly.
(5) it samples, detection, after qualified, filtering, 38 DEG C of whens discharge.
Table 1 (parts by weight)
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Palmityl tetrapeptide -7 | 0.05 | 0.5 | 3 | 0.5 | 0.5 |
| Palmityl tripeptides -1 | 0.5 | 3 | 0.5 | 3 | 5 |
| Fibronectin | 0.1 | 2 | 2 | 3 | 2 |
| Cannabidiol | 0.1 | 3 | 3 | 2 | 3 |
Embodiment 2
The component and its content of crease-resistant Firm composition are referring to table 1
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: with embodiment 1
Embodiment 3
The component and its content of crease-resistant Firm composition are referring to table 1
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: with embodiment 1
Embodiment 4
The component and its content of crease-resistant Firm composition are referring to table 1
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: with embodiment 1
Embodiment 5
The component and its content of crease-resistant Firm composition are referring to table 1
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: with embodiment 1
Comparative example 1
The component and its content of crease-resistant Firm composition are referring to table 2
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: it is substantially the same manner as Example 2, the difference is that, palmityl tetrapeptide -7 is not added.
Table 2 (parts by weight)
Comparative example 2
The component and its content of crease-resistant Firm composition are referring to table 2
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: it is substantially the same manner as Example 2, the difference is that, do not add palmityl tripeptides -1.
Comparative example 3
The component and its content of crease-resistant Firm composition are referring to table 2
Crease-resistant Firm Essence, in terms of mass percentage: crease-resistant Firm composition 8.5%, xanthan gum 0.2%, transparent
Matter acid sodium 0.1%, Phenoxyethanol 0.3%, essence 0.05%, Cremophor RH40 0.15%, deionized water surplus.
Preparation method: it is substantially the same manner as Example 2, the difference is that, do not add cannabidiol.
Comparative example 4
Only contain palmityl tetrapeptide -7, specifically content is referring to table 2.
Comparative example 5
Only contain palmityl tetrapeptide -7 and palmityl tripeptides -1, concrete content is referring to table 2.
Compliance test result experiment
One, in vitro test
(1) free radical scavenging activity is tested
Sample to be tested: embodiment 1- embodiment 5, the anti-ageing Firm composition of comparative example 1- comparative example 5；
Reagent: 1,1- diphenyl -2- trinitrophenyl-hydrazine (DPPH), dehydrated alcohol；
Sample to be tested is prepared: taking the anti-ageing Firm combination of 20mg embodiment 1- embodiment 5, comparative example 1- comparative example 5 respectively
Object dissolves with dehydrated alcohol and is settled to 250mL, spare；
The preparation of DPPH: accurately weighing 20mg DPPH, and 250mL is dissolved and be settled to dehydrated alcohol, spare；
Instrument: ultra-violet and visible spectrophotometer, insulating box；
Method: the sample to be tested and 2mL DPPH solution by 2mL through preformulation are as having in the test tube sieved, as insulating box
In at 37 DEG C constant temperature 1h using dehydrated alcohol as blank control the absorbance A of each sample to be tested is measured at 517nmi, and press
Formula calculates clearance rate:
Clearance rate=[1- (Ai-Aj)/Ac] × 100%
Wherein, Ac: 2ml dehydrated alcohol adds the absorbance of 2mL DPPH solution；
Ai: 2mL test agent adds the absorbance of 2mL DPPH solution；
Aj: 2mL test agent adds the absorbance of 2mL ethanol solution；
Each sample to be tested surveys three groups of Duplicate Samples, averages, as a result as shown in the table
Table 3
From table 3 it can be seen that the anti-ageing Firm composition of embodiment 1- embodiment 5 has preferably free radical scavenging activity.
The anti-ageing Firm composition of comparative example 1- comparative example 5 has certain radicals scavenging effect, but obviously real not as good as embodiment 1-
Example 5, especially comparative example 3- comparative example 5 are applied, compared to other anti-ageing Firm compositions, under radicals scavenging effect has obviously
Drop illustrates that cannabidiol has preferable antioxidation, and palmityl tetrapeptide -7 and palmityl tripeptides -1 have certain resist
Oxidation, three have certain synergistic effect.
(2) promote the detection of soluble collagen secretion
Human fibroblasts will be cultivated in the DMEM culture medium containing 10%FBS, and is seeded on 48 orifice plates, cell attachment
Afterwards, culture medium exchange is carried out with the DMEM culture medium containing 0.25%FBS and magnesium ascorbyl phosphate, embodiment 1- is added and implements
The anti-apolexis composition of example 5 and comparative example 1- comparative example 5.After cultivating 72h, medium supernatant is recycled, is centrifugated, is surveyed
The content of soluble collagen in fixed gained supernatant.As a result such as table 4.
Table 4
From table 4, it can be seen that the crease-resistant Firm composition of embodiment 1- embodiment 5, which has, preferably promotees soluble collagen egg
White secretion.
Compared with Example 2, comparative example 1 does not contain palmityl tetrapeptide -7 to comparative example 1, and comparative example 3 is compared with embodiment 2,
Comparative example 2 does not contain palmityl tripeptides -1.From table 2 it can be seen that the rush soluble collagen of comparative example 2 and comparative example 3 point
The effect of secreting obviously not as good as embodiment 2, illustrates that palmityl tetrapeptide -7 and palmityl tripeptides -1 can enhance crease-resistant Firm composition
Promote collagen synthesis effect.
In addition, comparative example 3 is compared with embodiment 2, comparative example 3 does not contain cannabidiol, from table 2 it can be seen that comparative example 3
Rush soluble collagen secretion decrease compared to embodiment 2.Illustrate cannabidiol for enhancing crease-resistant Firm
The rush collagen synthesis of composition also has having certain effect.
Comparative example 4 only contains palmityl tetrapeptide -7, and content is equal to the crease-resistant Firm composition of embodiment 2, and comparative example 5 is only
Palmityl tetrapeptide -7 and palmityl tripeptides -1 containing palmityl tetrapeptide -7 and palmityl tripeptides -1, in content and embodiment 2
It is equal.From table 2 it can be seen that the rush soluble collagen secretion of comparative example 4 and comparative example 5 is obviously not so good as embodiment 2,
Illustrate there is apparent synergistic effect between palmityl tetrapeptide -7 and other components.
Two, clinical test
Tester: volunteer 80, the age was at 28-60 years old；Volunteer is divided into 4 groups, every group 20, is tested respectively
State the crease-resistant Firm Essence of embodiment 2 and comparative example 1- comparative example 3；
Inclusion criteria: dry skin, elasticity reduces, occurs that wrinkle, the colour of skin are dark yellow etc. to have the volunteer of skin, but
No any skin and systemic disease suffer from history, and hormone medicine is not used in nearly one month；
Product uses rule: during testing first 2-3 days and entirely test, being changed without skin care item, and do not use any hormone
Class drug, daily each 1 time of morning and evening.
1. patch test:
The patch test of embodiment 2, comparative example 1- comparative example 3 is carried out to volunteer 80, wherein table 5 indicates that skin is bad
React grade scale, test result such as table 6.
Table 5 is skin adverse reaction grading standard
6 patch test results of table
Test group all has no adverse reaction, and can carry out follow-up test.
2. skin wrinkle improves situation；
Instrument: VISA face-image analysis system
Test method: being tested by standard of crow's feet, takes the skin of same area when test as far as possible every time, when test
Loosen.Comparison improves situation before and using wrinkle after one month, three months, and each region is surveyed 3 times every time, is averaged.
Evaluation criteria:
10 points, without wrinkle；
7-9 points, there is 2-3 wrinkle, length is less than 1.5cm；
4-6 points, there is 3-6 wrinkle, length is less than 3cm；
1-3 points, there are several main wrinkles, length is greater than 4cm, is also accompanied by shallow wrinkle.
Test result is as follows table 7
As can be seen from Table 7, the wrinkle remission effect of embodiment 2 is better than comparative example 1- comparative example 3.Illustrate palmityl four
Peptide -7, palmityl tripeptides -1 and cannabidiol all have wrinkle relaxation effect different degrees of booster action.
3. elasticity of skin improves situation
Instrument: MPA580 skin elasticity tester
Evaluation criteria: skin elasticity index R2It indicates, R2Illustrate that skin elasticity is better closer to 1 (100%), to every group
R2Fingering row statistics, and take mean value.Test result such as table 8.
Table 8
(* * p < 0.01)
As can be seen from Table 8, volunteer's elasticity of skin situation improvement situation of embodiment 2 is substantially better than comparative example 1- comparison
Example 3 illustrates that elasticity of skin can be improved in the product of embodiment 2.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of crease-resistant Firm composition, which is characterized in that in parts by weight, the crease-resistant Firm composition includes with the following group
Point:
2. crease-resistant Firm composition according to claim 1, which is characterized in that in the crease-resistant Firm composition, institute
Stating palmityl tetrapeptide -7 is 0.1-2 parts, and the palmityl tripeptides -1 are 1-5 parts, and the fibronectin is 0.1-2 parts, described big
Numb diphenol is 0.5-5 parts.
3. crease-resistant Firm composition according to claim 1 or 2, which is characterized in that the palmityl tetrapeptide -7 and described
The mass ratio of palmityl tripeptides -1 is 1:(5-6)；And/or
The mass ratio of the fibronectin and the cannabidiol is 2:(2.5-3.5).
4. the described in any item crease-resistant Firm compositions of claim 1-3 are preparing the application in skin care item.
5. a kind of crease-resistant Firm Essence, which is characterized in that including the described in any item crease-resistant Firm combinations of claim 1-3
Acceptable solvent on acceptable auxiliary material and skin care item on object, skin care item.
6. crease-resistant Firm Essence according to claim 5, which is characterized in that in the crease-resistant Firm Essence, with
Mass percentage meter, the crease-resistant Firm composition are 1.2%-14%, and the auxiliary material is 0.3%-3%, and the solvent is
83%-98.5%.
7. crease-resistant Firm Essence according to claim 6, which is characterized in that the auxiliary material include moisturizer, thickener,
Solubilizer, preservative and odorant；And in the crease-resistant Firm Essence, in terms of mass percentage, the moisturizer is
0.03%-0.2%, the thickener are 0.01%-0.5%, and the solubilizer is 0.05%-0.3%, and the preservative is
0.2%-0.6%, the odorant are 0.01%-0.1%.
8. crease-resistant Firm Essence according to claim 7, which is characterized in that the moisturizer is Sodium Hyaluronate；With/
Or
The thickener is xanthan gum；And/or
The solubilizer is Cremophor RH40；And/or
The preservative is Phenoxyethanol；And/or
The odorant is essence.
9. the preparation method of the described in any item crease-resistant Firm Essences of claim 5-8, which is characterized in that including following step
It is rapid:
The crease-resistant Firm composition, the auxiliary material and the solvent are mixed, the crease-resistant Firm Essence is made.
10. crease-resistant Firm Essence according to claim 9, feature are being, by the crease-resistant Firm composition, institute
State the step of auxiliary material and the solvent mix the following steps are included:
The thickener, the moisturizer and the solvent are mixed, are stirred under conditions of 70 DEG C -75 DEG C；
50 DEG C -55 DEG C are cooled to, and the palmityl tetrapeptide -7 and the palmityl tripeptides -1 are added, is uniformly mixed；
41 DEG C -45 DEG C are cooled to, and the fibronectin and the cannabidiol is added, is uniformly mixed；
25 DEG C -40 DEG C are cooled to, and the preservative, the solubilizer and the odorant is added, is uniformly mixed.
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| CN113499301A (en) * | 2021-07-14 | 2021-10-15 | 广州品域美妆创新科技有限公司 | Messenger peptide-containing composition and application thereof |
| WO2022013227A1 (en) * | 2020-07-15 | 2022-01-20 | France Cosmephyl-Lab | Novel compositions combining hemp derivatives and at least one peptide and use thereof |
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| CN107898657A (en) * | 2017-12-08 | 2018-04-13 | 广州赛莱拉干细胞科技股份有限公司 | Eye mask containing stem cell secretion factors |
| CN109528610A (en) * | 2018-12-21 | 2019-03-29 | 广州科恩生物技术有限公司 | One kind repairing Essence and preparation method thereof based on private gene customization |
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| WO2022013227A1 (en) * | 2020-07-15 | 2022-01-20 | France Cosmephyl-Lab | Novel compositions combining hemp derivatives and at least one peptide and use thereof |
| FR3112478A1 (en) * | 2020-07-15 | 2022-01-21 | France Cosmephyl-Lab | New compositions combining hemp derivatives and at least one peptide and their use |
| CN111888314A (en) * | 2020-09-08 | 2020-11-06 | 广州研智化妆品有限公司 | Essence containing copper peptide and preparation method thereof |
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