CN110302091A

CN110302091A - A kind of anti aging effect composition of niacinamide-containing adenine-dinucleotide and its preparation method and application

Info

Publication number: CN110302091A
Application number: CN201910706064.6A
Authority: CN
Inventors: 梅杰; 钱军; 张许昌; 方金波; 巫俊峰; 蒋仪
Original assignee: Shenzhen Orchid Pavilion Science And Technology Co Ltd
Current assignee: Shenzhen Orchid Pavilion Science And Technology Co Ltd
Priority date: 2019-08-01
Filing date: 2019-08-01
Publication date: 2019-10-08
Anticipated expiration: 2039-08-01
Also published as: CN110302091B

Abstract

The present invention is a kind of anti aging effect composition and its preparation method and application of niacinamide-containing adenine-dinucleotide, a kind of composition is provided, nicotinamide adenine dinucleotide comprising 2~7 parts by weight, also one or both of the palmityl tripeptides -1 comprising 0.25~2 parts by weight of choosing group and the Sodium Ascorbyl Phosphate of 0.5~2 parts by weight.The present invention also provides the preparation method of the composition and its in the application in the composition for preparing anti aging effect.Composition provided by the invention has whitening outstanding, crease-resistant and moisturizing effect, being capable of effective delay skin aging.

Description

A kind of anti aging effect composition of niacinamide-containing adenine-dinucleotide and its preparation Method and purposes

Technical field

The invention belongs to pharmaceutical technology fields, and in particular to a kind of delay skin aging, the composition with beautification function And its preparation method and application.

Background technique

Skin is the maximum organ of human body, wrap in body surface, directly with external environment contact, have protection, excretion, The effects of adjusting body temperature and experiencing environmental stimuli.Skin divides epidermis, corium and three layers of subcutaneous tissue.Epidermis is in skin surface, again It can be divided into cuticula and germinal layer two parts.The groups of cells of keratinization just becomes scurf at cuticula after falling off.Germinal layer Cell constantly divides, and can supplement the cuticula to fall off.Germinal layer has melanocyte, and the melanin of generation can prevent ultraviolet light Damaging internal tissues.Corium is then dense connective tissue, there are many elastic fibers and collagenous fibres, therefore flexible and toughness.Very How much in close relations, and compactness with skin of the thickness of skin tissue and its fibr tissue and matrix, plumpness and rise relaxation Phenomenon of wrinkling is closely related, the concern by more and more Skin cosmesis scholars in recent years.Increase and the external world with the age The influence of factor (such as daylight), loss, the degradation of the dermal matrixs ingredients such as collagen, elastin laminin in human skin corium It is increasingly severe, lead to skin aging, generates wrinkle, skin is wax yellow, coarse, leather changes.How delay skin aging, mitigate The senile symptom generated is the hot spot for being constantly subjected to market and crowd's concern.

It is living that nicotinamide adenine dinucleotide participates in a variety of physiology such as cellular material metabolism, energy synthesis, cell DNA reparation It is dynamic, it plays an important role to body immunity.Under health status, nicotinamide adenine dinucleotide concentration is stablized in human body, Maintain every cell normal function.Intracorporal nicotinamide adenine dinucleotide concentration determines the process and journey of cell ageing Degree, concentration decline the process that can accelerate cell ageing.Nicotinamide adenine dinucleotide, which has been embodied in, " has used cosmetics former Expect catalogue (2015 editions) " in, Serial No. 07360.

It has had already appeared in the prior art and nicotinamide adenine dinucleotide is applied to skin anti-aging.Such as Chinese invention A kind of patent application " narrow ditribution partial size lotion and preparation method thereof with skin anti-aging " (publication number CN107837204A, publication date on March 27th, 2018), in disclosed lotion containing 2.5~10% anti-staling composition, 0.5 ~10% emulsifier, 5~20% grease, 65~85% water；Wherein, the anti-staling composition is by ribose, camphane two Alcohol, pinane diol, dimethyl sulfone, five kinds of substances of nicotinamide adenine dinucleotide in mass ratio 1: 0.5~2: 0.5~2: 1~3: 0.5~3 composition.It is optimal that the inventor of the invention thinks that only above-mentioned five kinds of substances are just able to achieve according to mass ratio combination Resisting age of skin effect.In addition, Chinese invention patent application " one kind, which is full of, moistens maintenance essence " (publication number CN108771643A, it is public Open on November 2018 day 19), disclose the powder of a kind of acetyl chitosamine comprising 0.1~10 parts by weight, 0.1~10 parts by weight Radix Stephaniae Tetrandrae extract, the Malus spectabilis fruit seed oil of 0.1~10 parts by weight, the lavender oil of 0.1~10 parts by weight and 0.1~10 parts by weight The composition of nicotinamide adenine dinucleotide, it is best to the curative effect of sensibility skin.

Although the combination for having had already appeared the anti-aging of some niacinamide-containing adenine-dinucleotides, having improved skin condition Object.But as global popular research field, the demand of skin anti-aging is also remote unmet.

Summary of the invention

In view of the deficiencies of the prior art, have the purpose of the present invention is to provide one kind and alleviate skin ageing symptoms, improve The composition of skin condition.The composition formula is simple, and definite effect is suitble to be prepared into a variety of exterior-applied formulations.

In order to realize above-mentioned technical effect, present invention employs the following technical solutions:

A kind of composition, the nicotinamide adenine dinucleotide comprising 2~7 parts by weight, also comprising being selected from 0.25~2 weight One or both of palmityl tripeptides -1 and the Sodium Ascorbyl Phosphate of 0.5~2 parts by weight of part.

As a preferred embodiment, the present invention provides a kind of composition I, the nicotinoyl amine gland comprising 2~7 parts by weight The Sodium Ascorbyl Phosphate of purine dinucleotides, the palmityl tripeptides -1 of 0.25~2 parts by weight and 0.5~2 parts by weight.

Preferably, in composition I of the present invention, the parts by weight of nicotinamide adenine dinucleotide are 3~5 parts, more excellent It is selected as 3~4 parts.

Preferably, in composition I of the present invention, the parts by weight of palmityl tripeptides -1 are 0.5~2 part, more preferably 0.75~2 part.

Preferably, in composition I of the present invention, the parts by weight of Sodium Ascorbyl Phosphate are 0.75~2 part, more preferably It is 1~1.75 part.

As a further preferred embodiment, a kind of composition I of the present invention, the nicotinoyl amine gland comprising 2~4 parts by weight is fast The Sodium Ascorbyl Phosphate of nicotinamide adenine dinucleotide, the palmityl tripeptides -1 of 0.5~1 parts by weight and 0.75~1.25 parts by weight.

As a further preferred embodiment, a kind of composition I of the present invention, the niacinamide comprising 3~4 parts by weight The Sodium Ascorbyl Phosphate of adenine-dinucleotide, the palmityl tripeptides -1 of 0.5~1 parts by weight and 1~1.25 parts by weight.

As a particularly preferred embodiment, a kind of composition I of the present invention, the nicotinoyl amine gland comprising 3 parts by weight is fast The Sodium Ascorbyl Phosphate of nicotinamide adenine dinucleotide, the palmityl tripeptides -1 of 0.75 parts by weight and 1.25 parts by weight.

As a preferred embodiment, the present invention also provides a kind of composition I, by two nucleoside of nicotinamide adenine Acid, palmityl tripeptides -1 and Sodium Ascorbyl Phosphate composition, the parts by weight of each component are as described above.

As another preferred embodiment, the present invention also provides a kind of composition II, the cigarette comprising 2~7 parts by weight The palmityl tripeptides -1 of amide adenine-dinucleotide and 0.25~2 parts by weight.

Preferably, in composition II of the present invention, the parts by weight of nicotinamide adenine dinucleotide are 3~5 parts, more excellent It is selected as 3~4 parts.

Preferably, in composition II of the present invention, the parts by weight of palmityl tripeptides -1 are 0.5~2 part, more preferably 0.75~2 part.

As a preferred embodiment, the present invention provides a kind of composition II, by nicotinamide adenine dinucleotide It is formed with palmityl tripeptides -1, the parts by weight of each component are as described above.

As there are also a kind of preferred embodiment, the present invention provides a kind of composition III, the cigarette comprising 2~7 parts by weight The Sodium Ascorbyl Phosphate of amide adenine-dinucleotide and 0.5~2 parts by weight.

Preferably, in composition III of the present invention, the parts by weight of nicotinamide adenine dinucleotide are 3~5 parts, more Preferably 3~4 parts.

Preferably, in composition III of the present invention, the parts by weight of Sodium Ascorbyl Phosphate are 0.75~2 part, more excellent It is selected as 1~1.75 part.

As a preferred embodiment, the present invention provides a kind of composition III, by nicotinamide adenine dinucleotide It is formed with Sodium Ascorbyl Phosphate, the parts by weight of each component are as described above.

It is also an object of the present invention to provide the systems of above-mentioned composition, composition I, composition II or composition III Preparation Method, including by each component according to quality proportioning be uniformly mixed to get.

It is also an object of the present invention to provide above-mentioned composition, composition I, composition II or composition III to make Application in the composition of standby anti aging effect.

One of a kind of composition of anti aging effect, including the composition I, composition II and composition III, also Including external preparation for skin acceptable auxiliary material；Wherein, on the basis of the quality of the composition of the anti aging effect, the combination The mass percent of object I, composition II or composition III are 2.75%~11%.

Preferably, on the basis of the quality of the composition of the anti aging effect, the composition I, composition II or group The mass percent for closing object III is 4.25%~9%.

It is highly preferred that on the basis of the quality of the composition of the anti aging effect, the composition I, composition II or The mass percent of composition III is 4.75%~8%.

Preferably, the composition of the anti aging effect further includes beauty additive 1%~10%；The beauty is special Effect additive includes but is not limited to one of allantoin, bisabolol, panthenol, extract solution from aloe and dipotassium glycyrrhizinate or any Ratio it is a variety of.

Preferably, the composition of the anti aging effect is one of aqua, lotion, creme, paste, finish and facial mask Or it is a variety of.

It is also an object of the present invention to provide the preparation methods of the composition of the anti aging effect, including will be described Any one of composition I, composition II and composition III and the external preparation for skin acceptable auxiliary material are normal according to this field The method of rule is prepared into the dosage form of needs.

" anti aging effect " of the present invention refers to crease-resistant, whitening and moisturizing.

" parts by weight " described herein refer to the relative usage proportion relation between each component, are not specific quality lists Position.According to the actual situation, 1 parts by weight can be any gram, any kilogram, such as 1g, 3g, 5g, 10g, 100g, 1kg, etc..

External preparation for skin acceptable auxiliary material described herein includes but is not limited to: solvent such as water, alcohol etc., moisturizer is such as Glycerol, butanediol, trehalose, Sodium Hyaluronate etc., matrix such as atoleine, vaseline, dimethyl silicone polymer, palm acid ethyl Own ester, cetostearyl alcohol, beeswax, lanolin, stearic acid etc., thickener such as xanthan gum, carbomer, hydroxyethyl cellulose etc., cream Agent such as ceteareth -25, ceteareth -6, TWEEN Series, Span series etc., chelating agent such as EDTA bis- Sodium, trisodium citrate etc., antioxidant such as Butylated Hydroxytoluene, tocopherol acetate etc., solubilizer such as Cremophor RH40 etc., Preservative such as parahydroxyacet-ophenone, 1,2- hexylene glycol, Phenoxyethanol, methyl p-hydroxybenzoate etc..

Composition provided by the invention specifically includes composition I, composition II and composition III, each component and is embodied in In " having used cosmetic material catalogue (2015 editions) ", the wherein Serial No. 07360 of nicotinamide adenine dinucleotide, palm The Serial No. 08747 of acyl tripeptides -1, the Serial No. 04100 of Sodium Ascorbyl Phosphate.Composition safety of the invention It is good, it can be used for a long time.

The composition I, composition II and composition III provided by the invention, with exact delay skin aging Effect, is embodied in effectively reduce and mitigates that wrinkle, so that skin color is shoaled glossy.Wherein, the effect of composition I is best.

Specific embodiment

The present invention is described below with reference to specific embodiments.It will be appreciated by those skilled in the art that these embodiments are only For illustrating the present invention, do not limit the scope of the invention in any way.

Experimental method in following embodiments is unless otherwise specified conventional method.Original as used in the following examples Material, reagent material etc. are commercially available products unless otherwise specified.Wherein, part material and reagent purchase situation are as follows:

Nicotinamide adenine dinucleotide (NAD+) is purchased from Thailand, nation bioengineering (Shenzhen) Co., Ltd, specifications and models: BT01, dispatch from the factory lot number: BT01N118C005, content: 99.3%.

Palmityl tripeptides -1 are purchased from Shandong Ji Tai Biotechnology Co., Ltd, specifications and models: 1000mg/Kg, factory batch Number: JT20190103, content: 0.1%, surplus is water, polysorbate -20.

Sodium Ascorbyl Phosphate, purchased from Dutch Royal DSM, specifications and models: STAY-C 50, dispatch from the factory lot number: UE01611080, content: 99.2%.

In following research example and embodiment, unless otherwise specified, percent concentration (%) each means mass percent Concentration (w/w%).

Study example 1The influence of palmityl tripeptides -1 and Sodium Ascorbyl Phosphate to NAD+ anti-aging effects

Tested material:

1.NAD+ stoste:

NAD+5%, glycerol 10%, Sodium Hyaluronate 0.15%, parahydroxyacet-ophenone 0.3%, 1,2- hexylene glycol 0.5%, Surplus is purified water.

Preparation method: prepare each raw material according to formula；Purified water, parahydroxyacet-ophenone are added in agitated kettle, opened 80~85 DEG C are warming up to, keeps the temperature 30 minutes.After glycerol and Sodium Hyaluronate are mixed evenly, it is added in agitated kettle, Insulated and stirred 15 minutes.Then start to cool down.45 DEG C are cooled to, 1,2- hexylene glycol, NAD+ is added, stirs evenly.It is cooled to 35 DEG C, with 200 mesh filter screen filtrations to get.

- 1 stoste of 2.NAD+ and palmityl tripeptides

Take the NAD+ stoste, palmityl tripeptides -1 be added, make its concentration 1%, stir evenly to get.

3.NAD+ and Sodium Ascorbyl Phosphate stoste

Take the NAD+ stoste, Sodium Ascorbyl Phosphate be added, makes its concentration 1%, stir evenly to get.

4.NAD+ and palmityl tripeptides -1, Sodium Ascorbyl Phosphate stoste

The NAD+ stoste is taken, palmityl tripeptides -1 and Sodium Ascorbyl Phosphate is added, making its concentration is 1%, is stirred Mix uniformly to get.

Tested volunteer requires:

It chooses healthy volunteer and is no less than 28, stochastic averagina is divided into 4 groups.

Selection standard: 1, men and women is unlimited, and the age was at 20~65 years old；2, health, without any skin or systemic disease Sufferer history；3, cooperate this test, attitude is conscientious, has certain expressive faculty, the impression after energy actual response use；4, voluntarily Participate in, and sign informed consent form, the requirement of research approach can be strictly observed, use product by research approach requirements and completion with It visits.

Exclusion criteria: the 1, women of gestation or nursing period；2, sensitive；3, skin of face breakage or the observation that has an impact The skin patient of facial state；4, face used laser, chemical peeling, creotoxin, skin filling or facelift；5, close There is sunburn in 1 month；6, other facial clinical researches were participated in current or 3 months nearly or received dermatologist's treatment Person.

Terminate and reject standard: 1, volunteer requires termination test；2, volunteer's compliance is bad；3, due to adverse reaction Or special physiological pathological change etc., it can not continue to test；4, other skin care item influential on this test are used in test；5, it connects It is irradiated by excessive ultraviolet light.

Testing procedure:

Recipient site is unified for face skin.

Subject first cleans recipient site with warm water, and is blotted the extra water of face with chipless water-absorbing dry paper handkerchief.In room Sit quietly 20min in the environment of warm (20 ± 2 DEG C) and relative humidity 50% ± 5%.Take 2.0g ± 0.02g tested material equal according to grouping It is even to be applied to subject's face skin.Sooner or later respectively primary using tested material daily.Continuous use 30 days.31st day volunteer to by Feeling and the sensory evaluation after of examination object are given a mark, and each group items average value is recorded and calculated.

Standards of grading:

Using 1~100 point of standards of grading processed:

It is 1~20 point, worse using rear effect；21~40 points, without effect；41~60 points, effect is general；61~80 points, Significant effect；81~100 points, effect highly significant.

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 1.

The influence of 1 palmityl tripeptides -1 of table and Sodium Ascorbyl Phosphate to NAD+ anti-aging effects

Tested material sample	Anti-wrinkle effect	Whitening effect	Moisturizing effect	Average score
					NAD+ stoste	78	71	80	76.33
NAD+ and palmityl tripeptides -1	88	76	86	83.33
					NAD+ and Sodium Ascorbyl Phosphate	79	85	88	84.00
NAD+, palmityl tripeptides -1 and Sodium Ascorbyl Phosphate	92	88	90	90.00

As seen from the above table:

1) compared with NAD+ is used alone, palmityl tripeptides -1 can obviously reinforce the anti-wrinkle effect of NAD+.Palmityl three Peptide -1 can be obviously promoted skin collagen, fibronectin splicing variants and hyaluronic acid as signal transmitting micromolecular polypeptide Synthesis can significantly reduce wrinkle depth, density and average external volume, improve skin skin quality and skin roughness.

2) Sodium Ascorbyl Phosphate can obviously reinforce whitening and the repairing effect of NAD+.Sodium Ascorbyl Phosphate It can effectively clear the free radical in skin as reducing agent, free radical damage caused by skin can be mitigated, thus enhance NAD+ Anti-aging effects.

3) in all tested materials, palmityl tripeptides -1 and ascorbic acid sodium phosphate joint, enhancing NAD+ anti-aging Effect is best.

Conclusion: palmityl tripeptides -1 and ascorbic acid sodium phosphate can enhance the effect of NAD+ anti aging effect respectively, The effect that three shares is best.

Study example 2The optimization of composition proportion in composition provided by the invention

(1) optimization of NAD+ dosage

Tested material:

According to the preparation method of NAD+ stoste described in research example 1, a series of NAD+ solution is prepared respectively, NAD+'s is dense Degree is 0%, 1%, 2%, 3%, 4%, 5%, 6%, 7% and 8%.

Trial volunteer:

It chooses healthy volunteer and is no less than 45, stochastic averagina is divided into 9 groups.

Selection standard, exclusion criteria, termination and rejecting standard: with " research example 1 ".

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 2.

Influence of the 2 NAD+ dosage of table to skin anti-aging effect

NAD+ concentration (%)	Anti-wrinkle effect	Whitening effect	Moisturizing effect	Average score
					0	40	35	45	40.00
1	60	55	65	60.00
					2	68	66	76	70.00
3	78	71	80	76.33
					4	78	71	80	76.33
5	78	71	80	76.33
					6	78	70	75	74.33
7	78	65	70	71.00
					8	78	63	30	57.00

As shown in Table 2, when the concentration of NAD+ is 2%~7%, there are apparent anti-aging effects, more than 7%, repair Effect sharply declines instead.And NAD+ concentration be 3%~5% when, skin items using effect has reached peak value, is further added by The dosage of NAD+ not can increase the scoring of every effect.Therefore, the preferred concentration range of NAD+ be 2%~4% or 2%~ 5%, preferred concentration range is 3%~4% or 3%~5%；In view of expensive, the optium concentration of NAD+ of NAD+ It is 3%.

(2) optimization of -1 dosage of palmityl tripeptides

Tested material:

According to the preparation method of research example 1, the stoste that NAD+ concentration is 3% is prepared, by palmityl tripeptides -1 with certain Ratio is added in 3%NAD+ stoste, is prepared into a series of solution.

Subject:

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 3.

Influence of -1 additive amount of 3 palmityl tripeptides of table to skin using effect

The additive amount (%) of palmityl tripeptides -1	Anti-wrinkle effect	Whitening effect	Moisturizing effect	Average score
					0	78	71	80	76.33
0.25	82	73	83	79.33
					0.50	85	75	85	81.67
0.75	88	76	86	83.33
					1.00	88	76	86	83.33
1.25	88	76	86	83.33
					1.50	88	76	86	83.33
1.75	89	76	86	83.67
					2.00	89	76	86	83.67

As shown in Table 3, when the additive amount of palmityl tripeptides -1 is 0.25%, it can enhance the anti-aging effects of NAD+； When its content is 0.75%, skin items using effect basically reaches peak value, is further added by the additive amount of palmityl tripeptides -1, every Effect scoring still can slightly increase.Therefore palmityl tripeptides -1 are 0.25%~2% than more preferably concentration range, in the concentration In range, 0.5%~2%, 0.5%~1% and 0.75%~2% is preferred dosage；In view of palmityl tripeptides -1 Expensive, when the dosage of NAD+ is 3%, it is 0.75% that the optimum addition of palmitic acid acyl tripeptides -1, which is fixed tentatively,.

(3) optimization of Sodium Ascorbyl Phosphate dosage

Tested material:

According to the preparation method of research example 1, the stoste that NAD+ concentration is 3% is prepared, by Sodium Ascorbyl Phosphate with one Fixed ratio is added in 3%NAD+ stoste, is prepared into a series of solution.

Subject:

Selection standard, exclusion criteria and termination and rejecting standard: with " research example 1 ".

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 4.

Influence of the 4 Sodium Ascorbyl Phosphate additive amount of table to skin using effect

The additive amount (%) of Sodium Ascorbyl Phosphate	Anti-wrinkle effect	Whitening effect	Moisturizing effect	Average score
					0	78	71	80	76.33
0.25	78	73	82	77.67
					0.50	78	76	85	79.67
0.75	78	80	87	81.67
					1.00	79	85	88	84.00
1.25	79	85	87	83.67
					1.50	79	85	87	83.67
1.75	78	85	86	83.00
					2.00	78	85	82	81.67

As shown in Table 4, when the additive amount of Sodium Ascorbyl Phosphate is 0.5%, it can enhance NAD+ more significantly Anti-aging effects；When its content is 1.0%, skin items using effect reaches peak value, is further added by Sodium Ascorbyl Phosphate Additive amount, the average score of every effect is basically unchanged.When the dosage of Sodium Ascorbyl Phosphate reaches 2%, skin Using effect is declined compared with peak value, but with Sodium Ascorbyl Phosphate dosage 0.75% when is identical.Therefore ascorbic acid phosphoric acid Ester sodium is 0.5%~2% than more preferably amount ranges；Wherein, 0.75%~2% and 0.75%~1.25% is all further Preferred amount ranges, more preferable 1%~1.25% or 1%~1.75%；In view of the price of Sodium Ascorbyl Phosphate is high Expensive, when the dosage of NAD+ is 3%, it is 1.0% that the optimum addition of Sodium Ascorbyl Phosphate, which is fixed tentatively,.

Study example 3The ratio optimization of each Ingredient Amount in the present composition

Using orthogonal experiment, optimize NAD+, palmityl tripeptides -1, the use of Sodium Ascorbyl Phosphate in the present composition Amount ratio.

Selection NAD+ (A), palmityl tripeptides -1 (B), the mass percentage content of Sodium Ascorbyl Phosphate (C) are orthogonal The factor of test, evaluation criterion are the average score of using effect, and factor level table see the table below 5.According to the method system of research example 1 Then standby each tested material is chosen tested volunteer (45 people), grouping (5 people/group) according to the method for research example 1 and is tested, Finally scored according to the standards of grading of research 1 by tested volunteer.Using average score as orthogonal experiments, specifically it is shown in Table 6。

5 factor level table of table

	A (NAD+) (%)	B (palmityl tripeptides -1) (%)	C (Sodium Ascorbyl Phosphate) (%)
				1	2	0.5	0.75
2	3	0.75	1.00
				3	4	1.00	1.25

6 Orthogonal experiment results of table

In table 6, I is corresponding first horizontal the sum of the comprehensive score of each factor, and II is that each factor is corresponding Second horizontal the sum of comprehensive score, III are the sum of the comprehensive score of the corresponding third level of each factor, and I/3 is each The average value of the corresponding first horizontal comprehensive score of a factor, II/3 are the corresponding second horizontal synthesis of each factor The average value of scoring, III/3 are the average value of the comprehensive score of the corresponding third level of each factor.R is each factor It is very poor.

As shown in Table 6, the corresponding comprehensive score highest of serial number 5 is tested, reaches 92 points, the experiment corresponding synthesis of serial number 9 is commented Divide secondly, comprehensive score is 91 points, experiment serial number 4 and the experiment corresponding comprehensive score of serial number 8 are 90 points.These scorings are high Highest scoring in aforementioned research example 2 illustrates that three kinds of ingredients produce apparent synergistic work with specific consumption proportion With.

The condition of aforementioned four experiment see the table below 7.

The intuitive analytical table of 7 orthogonal test of table

Tested number	NAD+ (%)	Palmityl tripeptides -1 (%)	Sodium Ascorbyl Phosphate (%)	Comprehensive score
					5	3	0.75	1.25	92.00
9	4	1.00	1.00	91.00
					4	3	0.50	1.00	90.00
8	4	0.75	0.75	90.00

By range analysis it is found that influencing maximum factor to comprehensive score is successively: A (NAD+) > C (ascorbic acid phosphoric acid Ester sodium) > B (palmityl tripeptides -1).The highest condition of comprehensive score is A₂B₂C₃, i.e. NAD+ dosage is 3%, palmityl tripeptides -1 Dosage is 0.75%, and Sodium Ascorbyl Phosphate dosage is 1.25%.

3 experimental verifications are carried out to the highest condition of comprehensive score, as a result as shown in table 8 below.

8 proving test of table

Tested number	NAD+ (%)	Palmityl tripeptides -1 (%)	Sodium Ascorbyl Phosphate (%)	Comprehensive score
					10	3	0.75	1.25	93
11	3	0.75	1.25	93
					12	3	0.75	1.25	93

Verification test the result shows that: NAD+3%, palmityl tripeptides -1 0.75% and Sodium Ascorbyl Phosphate 1.25% Combination, volunteer tries out comprehensive score highest, is most preferred combination of the invention.

Embodiment 1A kind of composition I and the solution containing the composition

The composition of composition I (500g) described in the present embodiment are as follows:

NAD+300g, -1 75g of palmityl tripeptides, Sodium Ascorbyl Phosphate 125g

Weigh NAD+300g, -1 75g of palmityl tripeptides, Sodium Ascorbyl Phosphate 125g and purified water 500g.By four Mixing, stirs evenly to get target solution；Storage temperature is -15~-20 DEG C, to prevent microorganism from growing.

Embodiment 2Anti-aging toner

The raw material of anti-aging toner (1000g) described in the present embodiment forms are as follows: the I's containing composition prepared by embodiment 1 Solution 100g, glycerol 50g, butanediol 30g, EDETATE SODIUM 0.2g, allantoin 1g, trehalose 5g, aloe barbadensis Miller extracting solution 50g, parahydroxyacet-ophenone 3g, 1,2- hexylene glycol 5g, Cremophor RH40 0.6g, essence 0.2g, purified water 755g.

It is prepared as follows: preparing each raw material according to formula.By purified water, glycerol, butanediol, EDETATE SODIUM, urine Bursin, trehalose, parahydroxyacet-ophenone are added in agitated kettle, are heated to 80~85 DEG C, keep the temperature 30 minutes.45 DEG C are cooled to, The mixed solution of Cremophor RH40 and essence is added.Be cooled to 35 DEG C, be added the I containing composition of embodiment 1 solution, Aloe barbadensis Miller extracting solution, 1,2- hexylene glycol, stir evenly.With 200 mesh filter screen filtrations to get.

In addition, preparing common toner of the 1000g without composition I described in embodiment 1 according to above-mentioned preparation method.Then Trial volunteer is tested according to the method for research example 1 and records scoring.

Trial volunteer:

Healthy volunteer 40 are chosen, stochastic averagina is divided into 2 groups.

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 9.

The toner of 9 embodiment 2 of table and common toner using effect compare

	Moisturizing effect	Anti-wrinkle effect	Whitening effect	Comprehensive score
					The toner of the present embodiment	95	95	91	94
Common toner	58	32	30	43.75

As shown in Table 9, every using effect of the toner containing present composition I is far superior to without the present invention The common toner of composition I.

Embodiment 3Anti-aging stoste

The composition of anti-aging stoste (1000g) raw material described in the present embodiment are as follows: the I's containing composition prepared by embodiment 1 is molten Liquid 100g, glycerol 80g, butanediol 30g, Sodium Hyaluronate 1.5g, EDETATE SODIUM 0.2g, allantoin 1g, trehalose 10g, Ku La It is rope extract solution from aloe 100g, parahydroxyacet-ophenone 3g, 1,2- hexylene glycol 5g, Cremophor RH40 0.6g, essence 0.2g, pure Change water 668.5g.

It is prepared as follows: preparing each raw material according to formula.By purified water, glycerol, EDETATE SODIUM, allantoin, sea Algae sugar, parahydroxyacet-ophenone are added in agitated kettle, are added to agitated kettle after butanediol and Sodium Hyaluronate are uniformly mixed In, 80~85 DEG C are heated to, keeps the temperature 30 minutes.45 DEG C are cooled to, the mixed solution of Cremophor RH40 and essence is added. 35 DEG C are cooled to, solution, aloe barbadensis Miller extracting solution, 1, the 2- hexylene glycol of the I containing composition prepared by embodiment 1, stirring is added Uniformly.With 200 mesh filter screen filtrations to get.

In addition, preparing common stoste of the 1000g without composition I described in embodiment 1 according to above-mentioned preparation method.Then it presses Trial volunteer is tested according to the method for research example 1 and records scoring.

Trial volunteer:

Healthy volunteer 40 are chosen, stochastic averagina is divided into 2 groups.

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 10.

The anti-aging stoste and common stoste using effect of 10 embodiment 3 of table compare

	Moisturizing effect	Anti-wrinkle effect	Whitening effect	Comprehensive score
					The stoste of embodiment 3	95	95	91	94
Common stoste	58	32	30	43.75

As shown in Table 10, every using effect of the stoste containing present composition I is far superior to without the present invention The common stoste of composition I.

Embodiment 4Anti-aging lotion

The composition of anti-aging lotion (1000g) raw material described in the present embodiment are as follows: the I's containing composition prepared by embodiment 1 is molten Liquid 100g, glycerol 50g, butanediol 30g, xanthan gum 2g, EDETATE SODIUM 0.2g, allantoin 1g, parahydroxyacet-ophenone 4g, spermaceti are hard - 25 15g of lipidol polyethers, -6 15g of ceteareth, cetostearyl alcohol 30g, atoleine 30g, vaseline 10g, fourth hydroxyl first Benzene 0.5g, dimethyl silicone polymer 10g, ethylhexyl palmitate 10g, bisabolol 1g, tocopherol acetate 5g, 1,2- oneself two Alcohol 5g, essence 1g, purified water 680.3g.

It is prepared as follows: preparing each raw material according to formula.By purified water, EDETATE SODIUM, allantoin, para hydroxybenzene Ethyl ketone, ceteareth -25 are added in water phase pot, and unlatching is warming up to 80~85 DEG C.By glycerol, butanediol, xanthan gum After being dispersed with stirring in advance with container uniformly, it is added in water phase pot.Water phase pot insulated and stirred 30 minutes.Cetostearyl alcohol is gathered Ether -6, cetostearyl alcohol, atoleine, vaseline, Butylated Hydroxytoluene, dimethyl silicone polymer, ethylhexyl palmitate are added to oil In phase pot, unlatching is warming up to 80~85 DEG C, and stirring to oil phase material is completely dissolved.First water phase material is added in emulsion pot, Then oil phase material is added in emulsion pot again, is opened homogeneous 5 minutes, after stirring 10 minutes, start to cool down.It is cooled to 45 DEG C, bisabolol, tocopherol acetate, essence is added, stirs evenly.35 DEG C are cooled to, the preparation of embodiment 1 is added contains combination Solution, 1, the 2- hexylene glycol of object I, stirs evenly.With 200 mesh filter screen filtrations to get.

In addition, preparing ordinary emulsion of the 1000g without composition I described in embodiment 1 according to above-mentioned preparation method.Then it presses Trial volunteer is tested according to the method for research example 1 and records scoring.

Trial volunteer:

Healthy volunteer 40 are chosen, stochastic averagina is divided into 2 groups.

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 11.

The anti-aging lotion and ordinary emulsion using effect of 11 embodiment 4 of table compare

	Moisturizing effect	Anti-wrinkle effect	Whitening effect	Average score
					The lotion of embodiment 4	96	95	92	94.75
Ordinary emulsion	78	38	35	54

As shown in Table 11, every using effect of the lotion containing present composition I is far superior to without the present invention The ordinary emulsion of composition I.

Embodiment 5Anti-aging face cream

(1000g) raw material of anti-aging face cream described in the present embodiment composition are as follows: the I's containing composition prepared by embodiment 1 is molten Liquid 100g, glycerol 50g, butanediol 50g, EDETATE SODIUM 0.3g, allantoin 1g, parahydroxyacet-ophenone 4g, carbomer 2.5g, spermaceti - 25 15g of stereth, -6 15g of ceteareth, cetostearyl alcohol 50g, atoleine 40g, vaseline 30g, poly- two Methylsiloxane 20g, ethylhexyl palmitate 20g, beeswax 20g, Butylated Hydroxytoluene 0.5g, triethanolamine 2g, bisabolol 1g, life Educate phenol acetic acid esters 5g, 1,2- hexylene glycol 5g, essence 1.5g, purified water 567.2g.

It is prepared as follows: preparing each raw material according to formula.By purified water, glycerol, butanediol, EDETATE SODIUM, urine Bursin, parahydroxyacet-ophenone, ceteareth -25 are added in water phase pot, and unlatching is warming up to 80~85 DEG C, keep the temperature 30 points Clock.By ceteareth -6, cetostearyl alcohol, vaseline, dimethyl silicone polymer, ethylhexyl palmitate, beeswax, fourth hydroxyl Toluene is added in oily phase pot, and unlatching is warming up to 80~85 DEG C, and stirring to oil phase material is completely dissolved.First water phase material is added Into emulsion pot, then oil phase material is added in emulsion pot again.Atoleine and carbomer are stirred in advance with container and divided It dissipates uniformly, is added in emulsion pot, stirs evenly.It opens homogeneous 5 minutes, after stirring 10 minutes, starts to cool down.It is cooled to 65 DEG C, triethanolamine is added, stirs evenly.45 DEG C are cooled to, bisabolol, tocopherol acetate, essence is added, stirs evenly. 35 DEG C are cooled to, solution, 1, the 2- hexylene glycol of the I containing composition prepared by embodiment 1 is added, stirs evenly.With 200 mesh filter screens Filtering to get.

In addition, preparing common face cream of the 1000g without composition I described in embodiment 1 according to above-mentioned preparation method.Then it presses Trial volunteer is tested according to the method for research example 1 and records scoring.

Trial volunteer:

Healthy volunteer 36 are chosen, stochastic averagina is divided into 2 groups.

Testing procedure:

With " research example 1 ".

Standards of grading:

With " research example 1 ".

As a result:

Each group subject completes whole tests, does not have the case where terminating or being removed.Each item rating of each group Average value is shown in Table 12.

The face cream of 12 embodiment 5 of table and common face cream using effect compare

	Moisturizing effect	Anti-wrinkle effect	Whitening effect	Average score
					The face cream of embodiment 5	96	95	93	95
Common face cream	83	39	32	55.5

As shown in Table 12, every using effect of the face cream containing present composition I is far superior to free of described group Close the common face cream of object I.

Embodiment 6Anti-aging eye essence

(1000g) raw material of anti-aging eye essence described in the present embodiment forms are as follows: the I's containing composition prepared by embodiment 1 Solution 100g, glycerol 50g, butanediol 50g, EDETATE SODIUM 0.3g, carbomer 5g, triethanolamine 4g, allantoin 1g, the poly- first of glycerol Base acrylate 50g, beta glucan 5g, hydrolytic collagen 20g, glucose aminoglucan 20g, parahydroxyacet-ophenone 4g, 1,2- oneself Glycol 5g, essence 0.2g, Cremophor RH40 0.6g, purified water 684.9g.

It is prepared as follows: preparing each raw material according to formula.Purified water is added in agitated kettle, then by card wave Nurse is sprinkling upon on the water surface of agitated kettle, and standing is spontaneously wet out by water completely to carbomer.By glycerol, butanediol, EDETATE SODIUM, allantoin, Parahydroxyacet-ophenone is added in agitated kettle, is heated to 80~85 DEG C, keeps the temperature 30 minutes.65 DEG C are cooled to, triethanolamine is added It stirs evenly.55 DEG C are cooled to, glycerol polymethacrylates, beta glucan, hydrolytic collagen, glucose aminoglucan is added, It stirs evenly.45 DEG C are cooled to, the mixed solution of Cremophor RH40 and essence is added, stirs evenly.35 DEG C are cooled to, Solution, 1, the 2- hexylene glycol of the I containing composition prepared by embodiment 1 is added, stirs evenly.With 200 mesh filter screen filtrations to get.

In addition, preparing common eye essence of the 1000g without composition I described in embodiment 1 according to above-mentioned preparation method.Then According to research example 1 method to trial volunteer, (totally 44, stochastic averagina is divided into 2 groups；Selection standard, exclusion criteria and termination Rejecting standard is the same as " research example 1 ".) scoring is tested and is recorded, but trial volunteer is sooner or later uniform by eye essence twice It is applied to eye circumference to enclose, each 0.1g.

The average value for calculating and recording each item rating of volunteer, is shown in Table 13.

13 embodiment of table, 6 essence and common eye essence compare

	Moisturizing effect	Anti-wrinkle effect	Whitening effect	Average score
					Eye essence of the invention	96	95	93	95
Common eye essence	79	71	40	66.25

As shown in Table 13, every using effect of the eye essence containing present composition I is far superior to without containing this The common eye essence of inventive composition I.

Embodiment 7Anti-aging mask

The anti-aging mask of the present embodiment includes mask Essence and mask substrate.The original of the mask Essence Material composition are as follows: solution 100g, glycerol 50g, butanediol 30g, the EDETATE SODIUM 0.2g, allantois of the I containing composition prepared by embodiment 1 Plain 1g, dipotassium glycyrrhizinate 1.5g, trehalose 5g, panthenol 3g, hydroxyethyl cellulose 5g, parahydroxyacet-ophenone 3g, 1,2- hexylene glycol 5g, Cremophor RH40 0.3g essence 0.1g, purified water 795.9g.

It is prepared as follows: preparing each raw material of mask Essence according to formula；Purified water is added to agitated kettle In, it then adds hydroxyethyl cellulose into agitated kettle, stirs evenly.It is then turned on and is warming up to 80~85 DEG C.By glycerol, fourth Glycol, EDETATE SODIUM, allantoin, parahydroxyacet-ophenone are added in agitated kettle, keep the temperature 30 minutes.55 DEG C are cooled to, is added sweet Oxalic acid dipotassium, trehalose, panthenol, stir evenly.45 DEG C are cooled to, the mixing that Cremophor RH40 and essence is added is molten Liquid stirs evenly.35 DEG C are cooled to, solution, 1, the 2- hexylene glycol of the I containing composition prepared by embodiment 1 is added, stirs evenly. With 200 mesh filter screen filtrations to get mask Essence.Mask Essence is poured by grouter and is pre-loaded with facial mask base The facial mask bag of cloth, sealing.

In addition, preparing common mask of the 1000g without composition I described in embodiment 1 according to above-mentioned preparation method.Then Trial volunteer's (totally 28 people, stochastic averagina are divided into 2 groups) is tested according to the method for research example 1 and records scoring, only Subject's every night in tested facial mask 20 minutes of facial application, is used in conjunction 7 days.

The average value for calculating and recording each item rating of volunteer, is shown in Table 14.

The mask of 14 embodiment 7 of table and common mask using effect compare

	Moisturizing effect	Anti-wrinkle effect	Whitening effect	Average score
					7 mask of embodiment	96	96	95	95.75
Common mask	88	58	49	68.25

As shown in Table 14, every using effect of the mask containing present composition I is far superior to free of this hair The common mask of bright composition I.

Embodiment 8A kind of composition II and the solution containing the composition

The composition of composition II (400g) described in the present embodiment are as follows:

- 1 100g of NAD+300g and palmityl tripeptides

Weigh -1 100g of NAD+300g and palmityl tripeptides, purified water 600g.Three is mixed, is stirred evenly to get mesh Mark solution；Storage temperature is -15~-20 DEG C, to prevent microorganism from growing.

Embodiment 9A kind of anti-aging face cream

(1000g) raw material of anti-aging face cream described in the present embodiment composition are as follows: the II's containing composition prepared by embodiment 8 is molten Liquid 100g, glycerol 50g, butanediol 50g, EDETATE SODIUM 0.3g, allantoin 1g, parahydroxyacet-ophenone 4g, carbomer 2.5g, spermaceti - 25 15g of stereth, -6 15g of ceteareth, cetostearyl alcohol 50g, atoleine 40g, vaseline 30g, poly- two Methylsiloxane 20g, ethylhexyl palmitate 20g, beeswax 20g, Butylated Hydroxytoluene 0.5g, triethanolamine 2g, bisabolol 1g, life Educate phenol acetic acid esters 5g, 1,2- hexylene glycol 5g, essence 1.5g, purified water 567.2g.

It is prepared as follows: preparing each raw material according to formula.By purified water, glycerol, butanediol, EDETATE SODIUM, urine Bursin, parahydroxyacet-ophenone, ceteareth -25 are added in water phase pot, and unlatching is warming up to 80~85 DEG C, keep the temperature 30 points Clock.By ceteareth -6, cetostearyl alcohol, vaseline, dimethyl silicone polymer, ethylhexyl palmitate, beeswax, fourth hydroxyl Toluene is added in oily phase pot, and unlatching is warming up to 80~85 DEG C, and stirring to oil phase material is completely dissolved.First water phase material is added Into emulsion pot, then oil phase material is added in emulsion pot again.Atoleine and carbomer are stirred in advance with container and divided It dissipates uniformly, is added in emulsion pot, stirs evenly.It opens homogeneous 5 minutes, after stirring 10 minutes, starts to cool down.It is cooled to 65 DEG C, triethanolamine is added, stirs evenly.45 DEG C are cooled to, bisabolol, tocopherol acetate, essence is added, stirs evenly. 35 DEG C are cooled to, solution 100g, 1, the 2- hexylene glycol of the II containing composition prepared by embodiment 8 is added, stirs evenly.With 200 mesh Filter screen filtration to get.

Embodiment 10A kind of composition III and the solution containing the composition

The composition of composition III (400g) described in the present embodiment are as follows:

NAD+300g and Sodium Ascorbyl Phosphate 100g

Weigh NAD+300g and Sodium Ascorbyl Phosphate 100g, purified water 600g.Three is mixed, is stirred evenly, i.e., Obtain target solution；Storage temperature is -15~-20 DEG C, to prevent microorganism from growing.

Embodiment 11Anti-aging lotion

The composition of anti-aging lotion (1000g) raw material described in the present embodiment are as follows: the III's containing composition prepared by embodiment 10 Solution 100g, glycerol 50g, butanediol 30g, xanthan gum 2g, EDETATE SODIUM 0.2g, allantoin 1g, parahydroxyacet-ophenone 4g, spermaceti - 25 15g of stereth, -6 15g of ceteareth, cetostearyl alcohol 30g, atoleine 30g, vaseline 10g, fourth hydroxyl Toluene 0.5g, dimethyl silicone polymer 10g, ethylhexyl palmitate 10g, bisabolol 1g, tocopherol acetate 5g, 1,2- oneself Glycol 5g, essence 1g, purified water 680.3g.

It is prepared as follows: preparing each raw material according to formula.By purified water, EDETATE SODIUM, allantoin, para hydroxybenzene Ethyl ketone, ceteareth -25 are added in water phase pot, and unlatching is warming up to 80~85 DEG C.By glycerol, butanediol, xanthan gum After being dispersed with stirring in advance with container uniformly, it is added in water phase pot.Water phase pot insulated and stirred 30 minutes.Cetostearyl alcohol is gathered Ether -6, cetostearyl alcohol, atoleine, vaseline, Butylated Hydroxytoluene, dimethyl silicone polymer, ethylhexyl palmitate are added to oil In phase pot, unlatching is warming up to 80~85 DEG C, and stirring to oil phase material is completely dissolved.First water phase material is added in emulsion pot, Then oil phase material is added in emulsion pot again, is opened homogeneous 5 minutes, after stirring 10 minutes, start to cool down.It is cooled to 45 DEG C, bisabolol, tocopherol acetate, essence is added, stirs evenly.35 DEG C are cooled to, the preparation of embodiment 10 is added contains group Solution, 1, the 2- hexylene glycol for closing object III, stir evenly.With 200 mesh filter screen filtrations to get.

In short, the present invention provides one kind based on nicotinamide adenine dinucleotide, compatibility palmityl tripeptides -1 and anti- The composition of one or both of bad hematic acid sodium phosphate.Composition of the invention has crease-resistant, whitening outstanding and moisturizing Effect.Application the present invention also provides the composition in the composition for preparing anti aging effect as a result,.

Later, start to cool down.65 DEG C are cooled to, triethanolamine is added, stirs evenly.45 DEG C are cooled to, opopanax is added Alcohol, tocopherol acetate, essence, stir evenly.35 DEG C are cooled to, the solution of the II containing composition prepared by embodiment 8 is added 100g, 1,2- hexylene glycol, stir evenly.With 200 mesh filter screen filtrations to get.

The composition of composition III (500g) described in the present embodiment are as follows:

NAD+300g and Sodium Ascorbyl Phosphate 100g

Weigh NAD+300g and Sodium Ascorbyl Phosphate 100g, purified water 600g.Three is mixed, is stirred evenly, i.e., Obtain target solution；It is stored at -15~-20 DEG C to prevent microorganism from growing.

Embodiment 11Anti-aging lotion

Claims

1. a kind of composition, the nicotinamide adenine dinucleotide comprising 2~7 parts by weight, also comprising being selected from 0.25~2 parts by weight Palmityl tripeptides -1 and one or both of the Sodium Ascorbyl Phosphate of 0.5~2 parts by weight.

2. a kind of composition I, the palmityl of the nicotinamide adenine dinucleotide comprising 2~7 parts by weight, 0.25~2 parts by weight The Sodium Ascorbyl Phosphate of tripeptides -1 and 0.5~2 parts by weight；

Preferably, in the composition I, the parts by weight of nicotinamide adenine dinucleotide are 3~5 parts, more preferably 3~4 parts；

Preferably, in the composition I, the parts by weight of palmityl tripeptides -1 are 0.5~2 part, more preferably 0.75~2 part；

Preferably, in the composition I, the parts by weight of Sodium Ascorbyl Phosphate are 0.75~2 part, more preferably 1~1.75 Part.

3. composition I according to claim 2, which is characterized in that the composition I includes the niacinamide of 2~4 parts by weight The ascorbic acid phosphoric acid esters of adenine-dinucleotide, the palmityl tripeptides -1 of 0.5~1 parts by weight and 0.75~1.25 parts by weight Sodium；

Preferably, the composition I includes the palm of the nicotinamide adenine dinucleotide of 3~4 parts by weight, 0.5~1 parts by weight The Sodium Ascorbyl Phosphate of the parts by weight of acyl tripeptides -1 and 1~1.25；

It is highly preferred that the composition I includes the palmityl of the nicotinamide adenine dinucleotide of 3 parts by weight, 0.75 parts by weight The Sodium Ascorbyl Phosphate of tripeptides -1 and 1.25 parts by weight；

It is particularly preferred that the composition I is by nicotinamide adenine dinucleotide, palmityl tripeptides -1 and ascorbic acid phosphoric acid esters Sodium composition, the parts by weight of each component are as described above.

4. a kind of composition II, the palm of the nicotinamide adenine dinucleotide comprising 2~7 parts by weight and 0.25~2 parts by weight Acyl tripeptides -1；

Preferably, in the composition II, the parts by weight of nicotinamide adenine dinucleotide are 3~5 parts, more preferably 3~4 Part；

Preferably, in the composition II, the parts by weight of palmityl tripeptides -1 are 0.5~2 part, more preferably 0.75~2 part；

It is particularly preferred that the composition II is made of nicotinamide adenine dinucleotide and palmityl tripeptides -1, each component Parts by weight are as described above.

5. a kind of composition III, the nicotinamide adenine dinucleotide comprising 2~7 parts by weight and 0.5~2 parts by weight is anti-bad Hematic acid sodium phosphate；

Preferably, in the composition III, the parts by weight of nicotinamide adenine dinucleotide are 3~5 parts, more preferably 3~4 Part；

Preferably, in the composition III, the parts by weight of Sodium Ascorbyl Phosphate are 0.75~2 part, more preferably 1~ 1.75 part；

It is particularly preferred that the composition III is made of nicotinamide adenine dinucleotide and Sodium Ascorbyl Phosphate, each group The parts by weight divided are as described above.

6. composition described in claim 1, composition I described in claim 2 or 3, composition II as claimed in claim 4 Or the preparation method of composition III described in claim 5, including each component is uniformly mixed according to quality proportioning, i.e., ?.

7. composition described in claim 1, composition I described in claim 2 or 3, composition II as claimed in claim 4 Or application of the composition III in the composition for preparing anti aging effect described in claim 5.

8. a kind of composition of anti aging effect, including composition described in claim 1, combination described in claim 2 or 3 One of composition III described in object I, composition II as claimed in claim 4 and claim 5, further includes external preparation for skin Acceptable auxiliary material；Wherein, on the basis of the quality of the composition of the anti aging effect, the composition, composition I, The mass percent of composition II or composition III are 2.75%~11%；

Preferably, on the basis of the quality of the composition of the anti aging effect, the composition, composition I, composition II or The mass percent of composition III is 4.25%~9%；

It is highly preferred that on the basis of the quality of the composition of the anti aging effect, the composition, composition I, composition II Or the mass percent of composition III is 4.75%~8%；

Preferably, the composition of the anti aging effect further includes beauty additive 1%~10%；The beauty special efficacy adds Agent is added to be selected from a variety of of one of allantoin, bisabolol, panthenol, extract solution from aloe and dipotassium glycyrrhizinate or arbitrary proportion.

9. anti aging effect composition according to claim 8, which is characterized in that the composition of the anti aging effect is One of aqua, lotion, creme, paste, finish and facial mask are a variety of.

10. the preparation method of the composition of the anti aging effect of claim 8 or 9, including by the composition, composition I, Any one of composition II and composition III are with the external preparation for skin acceptable auxiliary material according to the side of this field routine Method is prepared into the dosage form of needs.