CN113599298A - Composition for skin antibiosis and repair, preparation method and application thereof - Google Patents
Composition for skin antibiosis and repair, preparation method and application thereof Download PDFInfo
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- CN113599298A CN113599298A CN202111004257.0A CN202111004257A CN113599298A CN 113599298 A CN113599298 A CN 113599298A CN 202111004257 A CN202111004257 A CN 202111004257A CN 113599298 A CN113599298 A CN 113599298A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The application discloses a composition for skin antibiosis and repair, a preparation method and an application thereof, and belongs to the technical field of functional skin care products. The composition comprises: active peptide, nicotinamide adenine dinucleotide, calamine and water, wherein the pH value of the composition is 4.5-6. The composition can maintain weak acid environment of skin, inhibit bacteria generation, has anti-inflammatory effect on skin, and can prevent skin inflammation, and simultaneously, by adding active peptide and NAD, it is beneficial to proliferation and metabolism of skin cells, provide energy for cell differentiation, and promote rapid repair of skin inflammation.
Description
Technical Field
The application relates to a composition for skin antibiosis and repair, a preparation method and application thereof, and belongs to the technical field of functional skin care products.
Background
The skin is the largest organ of the human body, and the skin is not only an important barrier between the internal environment of the human body and the natural environment, but also an important organ for sensing the stimulation of natural signals. The skin has a sharp sensation of temperature, humidity, light, air flow, and pH, and plays an important role in preventing the invasion of bacteria and viruses.
The pH of healthy skin is usually kept between 4.0 and 6.5. The skin surface has a thin, acidic protective layer, which protects the skin from harmful bacteria and viruses. The protective layer is formed by mixing free fatty acid discharged from sebaceous glands of skin with lactic acid and amino acid in sweat.
Physical factors, chemical factors, light damage or allergy can change the pH of the skin surface, and the change of the skin pH can cause various skin problems, such as the acidic skin is easy to generate acne and secrete grease, and when the local slightly acidic environment of the skin reaches the pH of 2.0-3.0, erythema and epidermal inflammation can be caused; the mildly alkaline skin with a pH of 8.0 is drier and tends to wrinkle.
Conventional skin care products generally use weakly basic formulations in order to remove oil stains and metabolites from the skin surface, however, when the pH of the skin is alkaline, bacteria easily adhere and grow, causing skin inflammation and causing skin diseases.
Disclosure of Invention
In order to solve the problems, the composition for skin antibiosis and repair, and a preparation method and an application thereof are provided, the composition can maintain weak acid environment of skin, inhibit the generation of bacteria, has anti-inflammatory effect on the skin, and prevent the generation of skin inflammation, and simultaneously, by adding active peptide, NAD and other components, the composition is beneficial to the proliferation and metabolism of skin cells, provides energy for cell differentiation, and promotes the rapid repair of the skin inflammation.
According to one aspect of the present application, there is provided a composition for skin antisepsis and repair comprising: active peptide, nicotinamide adenine dinucleotide, calamine and water, wherein the pH value of the composition is 4.5-6.
Optionally, the composition comprises 0.1-0.25 part of active peptide, 4-6 parts of nicotinamide adenine dinucleotide, 10-14 parts of calamine and 4000-6000 parts of water by weight.
Alternatively, the composition has a pH of 5.5 in parts by mass; the composition comprises 0.19 part of active peptide, 5 parts of nicotinamide adenine dinucleotide, 12 parts of calamine and 5000 parts of water.
Preferably, the calamine is 5% by weight of calamine suspension.
Optionally, the active peptides comprise, in parts by mass: carnosine 0.05-0.1 part, palmitoyl tripeptide-10.02-0.1 part, tripeptide-1 copper 0.01-0.03 part and palmitoyl tetrapeptide-70.01-0.05 part;
preferably, the active peptide comprises the following components in parts by mass: carnosine 0.08 parts, palmitoyl tripeptide-10.06 parts, tripeptide-1 copper 0.02 parts and palmitoyl tetrapeptide-70.03 parts.
Optionally, the composition further comprises 30-40 parts by weight of cellulose;
preferably, the composition further comprises 35 parts by weight of cellulose.
Optionally, the composition further comprises 4-6 parts by weight of calcium ion supplement; preferably 5 parts;
preferably, the calcium ion supplement is calcium citrate.
Optionally, the composition further comprises a pH adjuster.
Preferably, the pH regulator is fruit acid.
Preferably, the pH regulator is malic acid, citric acid or tartaric acid.
Preferably, the pH adjusting agent is citric acid.
According to another aspect of the present application, there is provided a method for preparing the composition for skin antibiosis and repair of any one of the above, comprising the steps of: mixing the raw materials, adjusting pH to 4.5-6, and performing water bath at 25-45 deg.C.
Optionally, the method comprises the following steps: mixing carnosine, palmitoyl tripeptide-1, tripeptide-1 copper, palmitoyl tetrapeptide-7, nicotinamide adenine dinucleotide, calamine and calcium citrate, adding cellulose to form a mixed solution, adjusting the mixed solution to 5.5 by using a pH regulator, and bathing for 30min at 36 ℃.
According to a further aspect of the present application, there is provided a use of a composition according to any of the above or a composition prepared by a method according to any of the above for skin antisepsis and repair;
the application comprises applying the composition to the skin in the form of at least one of a cream, an emulsion, and a spray.
When the pH value is 5.5, the bioactive peptide biomacromolecules are positioned between a primary structure and a secondary structure, and the bioactivity and penetrability are best; in addition, the epidermal cells of the skin have a very sensitive pH dependence, the pH value being effective in regulating the amount of peptide bound per skin cell. When the pH of the skin microenvironment is about 5.5, 1300 lipids bind to 1 polypeptide, or each vesicle can encapsulate about 75 peptides, while one end of the active peptide is transferred into the cytoplasm through the membrane and the other end is retained in the extracellular space, thereby positioning the active peptide in the membrane lipid bilayer, i.e., the active peptide has dual delivery capacity to transport chemicals, small molecules, etc. of the substance to be transported into the cell. In addition, when the pH of the skin microenvironment is about 5.5, this results in protonation of negatively charged residues (Asp or Glu), increases the hydrophobicity of the active peptide, further increases the affinity of the active peptide for lipid bilayers, and triggers folding and subsequent membrane insertion processes of the active peptide, facilitating the absorption of the active peptide by the skin, promoting the proliferation and metabolism of skin cells.
The carnosine is added to provide an immune barrier for the skin and maintain endocrine balance; the tripeptide-1 copper can promote cell metabolism, stimulate cell proliferation and has the effect of resisting wrinkles; palmitoyl tetrapeptide-7 has antioxidant and anti-inflammatory effects.
According to the invention, through adding nicotinamide adenine dinucleotide (NAD for short) to be matched with carnosine, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, energy is provided for cell differentiation, cell proliferation is promoted, skin metabolism is facilitated, and the skin anti-wrinkle effect is achieved and rapid repair of skin inflammation is facilitated; the reasonable proportion of the NAD and the calamine can adjust the pH of the skin and maintain the acidic environment of the skin, and meanwhile, the calamine can maintain the NAD as a reduced NAD, which is beneficial to the absorption of the NAD and improves the anti-inflammatory and bacteriostatic effects of the composition on the skin.
According to the invention, through the synergistic effect of the added calamine, the palmitoyl tripeptide-1 copper and the palmitoyl tetrapeptide-7, the absorption of the tripeptide-1 copper can be enhanced, and the effects of inflammation resistance and bacteriostasis are achieved on the skin.
According to the invention, the cellulose is added, and the long-chain structure of the cellulose can prevent the aggregation of the active peptide, so that the absorption of the active peptide is facilitated; by adding calcium ions, the calcium ions lost by skin due to absorption of active peptide are supplemented, and the cell membrane potential is maintained.
Benefits of the present application include, but are not limited to:
1. the composition for skin antibiosis and repair can maintain a weak acid environment of skin, inhibit the generation of bacteria, has an anti-inflammatory effect on skin, and prevent the generation of skin inflammation, and meanwhile, by adding active peptide, NAD and other components, the composition is beneficial to the proliferation and metabolism of skin cells, provides energy for cell differentiation, and promotes the rapid repair of skin inflammation.
2. The composition has no toxic or side effect, can be used for a long time, has a good effect on maintaining the stability of the skin, and can be used as a paste, an emulsion or a spray to be used alone or be matched with other skin care products.
3. The preparation method of the composition is simple in steps and easy to operate.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:
fig. 1 is a diagram of a skin cell repair process using composition # 1 according to an example of the present application.
FIG. 2 is a graph of a skin cell repair process involving the present application without any composition.
Detailed Description
The present application will be described in detail with reference to examples, but the present application is not limited to these examples.
Unless otherwise specified, the raw materials and catalysts in the examples of the present application were all purchased commercially.
Example 1 preparation of the composition
The preparation method of the composition No. 1 comprises the following steps:
1) mixing 0.08g carnosine, 0.06g palmitoyl tripeptide-1, 0.02g tripeptide-1 copper, 0.03g palmitoyl tetrapeptide-7, 5g nicotinamide adenine dinucleotide, 240g calamine suspension with mass concentration of 5 wt% and 5g calcium citrate, adding into 5000g water, adding 35g cellulose to form a mixed solution;
2) adding citric acid, adjusting pH to 5.5, and bathing at 36 deg.C for 30min to obtain composition No. 1.
Preparing a composition No. 2-9 and a composition No. D1-D3 according to the preparation method of the composition No. 1, wherein the components of the composition No. 2-9 and the composition No. D1-D3 are shown in Table 1:
TABLE 1
Examples of the experiments
The test results of the antibacterial effect test, the cortical cell differentiation inhibition effect test, the anti-inflammatory effect test and the cell viability test are respectively carried out on the composition No. 1# -9# and the composition D1# -D3#, and the test methods are shown in Table 2 as follows:
(1) and (3) testing the antibacterial effect: diluting a 24-hour culture of propionibacterium acnes with 0.03mol/L phosphate buffer solution to 104-106 CFU/mL bacterial suspension; respectively taking 1g of the composition, adding the composition into a bacterial suspension, uniformly coating and mixing, recording the absorbance at 450nm of 0h, culturing at 37 ℃ for 24h to serve as a sample group, setting a blank group without the composition as a control group, recording the absorbance at 450nm, and calculating the bacteriostasis rate, wherein the bacteriostasis rate is (OD value of the control group-OD value of the sample group)/OD value of the control group multiplied by 100 percent.
(2) Anti-inflammatory effects: taking Raw264.7 cells in the optimal growth state, diluting to 7 × 104-9×104Inoculating 100 mu L of bacterial suspension into a 96-well plate per well, culturing in a 37 ℃ and 5% CO2 incubator, adding a composition with the mass concentration of 0.25% wt, treating for 24h to serve as a sample group, setting a blank group without the composition as a control group, taking supernate, detecting the inhibition effect of an active substance on interleukin by using an ELISA kit, and measuring the absorbance at 450nm by using an enzyme-linked immunosorbent assay (ELISA) instrument;
inhibition rate (control OD value-sample OD value)/control OD value × 100%.
(3) Cell viability assay: raw264.7 cells were cultured in RPMI1640 medium containing 10% fetal bovine serum under a culture condition of 5% at 37 ℃. Cells grown to 90% densityWhen it is used, it is made into 8X 104The method comprises the following steps of (1) inoculating the seeds in a 96-well plate at a density of/mL, attaching the seeds to the wall for 48 hours, adding a composition with a mass concentration of 0.25% wt, treating the mixture for 24 hours to serve as a sample group, setting a blank group without the composition as a control group, adding a CCK-8 reagent, incubating the blank group for 2 hours, and measuring the absorbance at 450 nm;
cell viability% ═ OD value of sample group/OD value of control group × 100%.
TABLE 2
As can be seen from the above table, the composition 1# -9# of the present invention can maintain a weak acid environment in the skin, inhibit the generation of bacteria, have an anti-inflammatory effect on the skin, prevent the generation of skin inflammation, maintain the activity of cells, facilitate the proliferation and metabolism of skin cells, provide energy for cell differentiation, and promote the rapid repair of skin inflammation.
In addition, when the composition 1# is subjected to the skin fibroblast scratch repair test, the test results are shown in fig. 1 and fig. 2, fig. 1 is a picture of the skin cell repair process using the composition 1# and fig. 2 is a picture of the skin cell repair process without using any composition, and it can be seen that the cell proliferation and recovery effect using the composition 1# of the present invention is significant, and thus the skin scratch repair speed is faster.
The above description is only an example of the present application, and the protection scope of the present application is not limited by these specific examples, but is defined by the claims of the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the technical idea and principle of the present application should be included in the protection scope of the present application.
Claims (10)
1. A composition for skin antisepsis and repair comprising: active peptide, nicotinamide adenine dinucleotide, calamine and water, wherein the pH value of the composition is 4.5-6.
2. The composition as claimed in claim 1, wherein the composition comprises active peptide 0.1-0.25 parts, nicotinamide adenine dinucleotide 4-6 parts, calamine 10-14 parts and water 4000-6000 parts by weight.
3. The composition of claim 1, wherein the composition has a pH of 5.5; the composition comprises, by mass, 0.19 part of active peptide, 5 parts of nicotinamide adenine dinucleotide, 12 parts of calamine and 5000 parts of water.
4. The composition of claim 1, wherein the active peptides comprise, in parts by mass: carnosine 0.05-0.1 part, palmitoyl tripeptide-10.02-0.1 part, tripeptide-1 copper 0.01-0.03 part and palmitoyl tetrapeptide-70.01-0.05 part;
preferably, the active peptide comprises the following components in parts by mass: carnosine 0.08 parts, palmitoyl tripeptide-10.06 parts, tripeptide-1 copper 0.02 parts and palmitoyl tetrapeptide-70.03 parts.
5. The composition according to any one of claims 1 to 4, wherein the composition further comprises 30 to 40 parts by mass of cellulose;
preferably, the composition further comprises 35 parts by weight of cellulose.
6. The composition according to any one of claims 1 to 4, wherein the composition further comprises 4 to 6 parts by mass of a calcium ion supplement;
preferably, the calcium ion supplement is calcium citrate.
7. The composition according to any one of claims 1 to 4, wherein the composition further comprises a pH adjusting agent;
preferably, the pH adjusting agent is citric acid.
8. A method for preparing a composition for skin antisepsis and repair according to any one of claims 1 to 7, comprising the steps of: mixing the raw materials, adjusting pH to 4.5-6, and performing water bath at 25-45 deg.C.
9. The method of claim 8, comprising the steps of: mixing carnosine, palmitoyl tripeptide-1, tripeptide-1 copper, palmitoyl tetrapeptide-7, nicotinamide adenine dinucleotide, calamine and calcium citrate, adding cellulose to form a mixed solution, adjusting the mixed solution to 5.5 by using a pH regulator, and bathing for 30min at 36 ℃.
10. Use of a composition according to any one of claims 1 to 7 or a composition prepared by a process according to any one of claims 8 to 9 for the antibacterial and reparative treatment of the skin;
the application comprises applying the composition to the skin in the form of at least one of a cream, an emulsion, and a spray.
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| CN202111004257.0A CN113599298B (en) | 2021-08-30 | 2021-08-30 | Composition for skin antibiosis and repair, preparation method and application thereof |
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| CN110302091A (en) * | 2019-08-01 | 2019-10-08 | 深圳市兰亭科技股份有限公司 | A kind of anti aging effect composition of niacinamide-containing adenine-dinucleotide and its preparation method and application |
| CN113181081A (en) * | 2021-04-01 | 2021-07-30 | 科丝美诗(中国)化妆品有限公司 | Cosmetic containing anti-inflammatory oil control functional composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302091A (en) * | 2019-08-01 | 2019-10-08 | 深圳市兰亭科技股份有限公司 | A kind of anti aging effect composition of niacinamide-containing adenine-dinucleotide and its preparation method and application |
| CN113181081A (en) * | 2021-04-01 | 2021-07-30 | 科丝美诗(中国)化妆品有限公司 | Cosmetic containing anti-inflammatory oil control functional composition and preparation method thereof |
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