CN107115220A - A kind of activity of fighting against senium compositions and preparation method and application - Google Patents
A kind of activity of fighting against senium compositions and preparation method and application Download PDFInfo
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- CN107115220A CN107115220A CN201710364718.2A CN201710364718A CN107115220A CN 107115220 A CN107115220 A CN 107115220A CN 201710364718 A CN201710364718 A CN 201710364718A CN 107115220 A CN107115220 A CN 107115220A
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- Prior art keywords
- activity
- fighting against
- against senium
- skin
- aging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to cosmetic field, and in particular to a kind of activity of fighting against senium compositions and preparation method and application.Described activity of fighting against senium compositions, include component as follows by mass percentage：Macromolecular Sodium Hyaluronate 0.1~5%；Micromolecule hyaluronic acid sodium 0.1~5%；HEGF 0.1~2%；Acetyl hexapeptide 8 0.01~0.1%；Carnosine 0.1~2%；Water supplies 100%.The active compositions have obvious anti-senescence function, during for preparing cosmetics, and consumption is 1~10%w/w, and using can reach obviously anti-aging effects after 30 days, skin becomes full, the young state of recovery of compacting.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of activity of fighting against senium compositions and preparation method thereof are with answering
With.
Background technology
Skin aging is the skin senescence phenomenon caused by natural cause or non-natural factor.Skin histology day after people's birth
Reach increasingly, function is gradually active.The growth stage of skin histology typically ends at 25 years old or so, enters simultaneously with aging from hereafter growth
OK, Elastic fibers are gradually thicker, 40~50 the beginning of the year old phase, and the aging of skin is slowly obvious.The aging of skin be it is a kind of from
Right rule, anti-aging is eternal beauty topic, although we can not prevent the natural aging of skin, but can be by science
Effective measures, change the aging state of skin.
Water laser accunputure is current popular anti-aging means, and its security is controversial.Some consumers liked to be beautiful are
The effect of instant obvious anti-aging is pursued, beauty is carried out in this way.So-called water laser accunputure or water laser accunputure skill
Art refers to the medical science skin makeup such as hyaluronic acid, hEGF and creotoxin nutritional ingredient is injected into skin corium by instrument and equipment, after injection
Skin-tightening is pale, full water profit.Though water laser accunputure can remold the skin for smooth high resilience of compacting, band in a short time
The side effect come is also apparent.Water laser accunputure is subcutaneously injected, and belongs to micro-shaping medical and beauty treatment, and its effect ＆ Safety is non-
Medical condition is often limited by, risk is larger.Therefore, the eager demand one kind of people seeking beauty is safer, effective and easily resists
Aging mode.Wherein turn into current preferred option using the anti-aging cosmetics of external application.Though but common anti-aging cosmetics
It is only conceptual addition in some cosmetics, i.e., so compared with water laser accunputure gently safety, but activity of fighting against senium composition therein is single
Just it is enough, also fail to consider its percutaneous absorbability and physiologically active, therefore its effect can not meet the expectation of consumer, it is just anti-
Come substantially far away from water laser accunputure for aging effects.
The content of the invention
In order to overcome the deficiencies in the prior art and shortcoming, primary and foremost purpose of the invention is to provide a kind of activity of fighting against senium thing
Composition.
Another object of the present invention is to provide the preparation method of above-mentioned activity of fighting against senium compositions.
It is still another object of the present invention to provide the application of above-mentioned activity of fighting against senium compositions.
The purpose of the present invention is achieved through the following technical solutions：
A kind of activity of fighting against senium compositions, include component as follows by mass percentage：
Described activity of fighting against senium compositions, preferably comprise following component by mass percentage：
Described activity of fighting against senium compositions, further preferably comprising following component by mass percentage：
The mean molecule quantity of described macromolecular Sodium Hyaluronate is preferably 1000000~1800000Da；
The mean molecule quantity of described micromolecule hyaluronic acid sodium is preferably ＜ 10000Da；
Described water is preferably deionized water；
The preparation method of described activity of fighting against senium compositions, is comprised the following steps：
The each component of above-mentioned activity of fighting against senium compositions is well mixed, activity of fighting against senium compositions are obtained；
Application of the described activity of fighting against senium compositions in cosmetic field；
Described cosmetics are preferably cosmetic preparation for skin care；
The consumption of anti-aging active matter composition is 1~10% (w/w) in described cosmetic preparation for skin care；
The consumption of anti-aging active matter composition is preferably 5~10% (w/w) in described cosmetic preparation for skin care；
In described cosmetic preparation for skin care, in addition to above-mentioned required composition, it can coordinate logical as suitably desired
The composition often used in cosmetics, for example, the matrix components such as surfactant, alcohols, water；
The formulation of described cosmetic preparation for skin care be preferably solution, suspension, emulsion, creme, paste, gel,
Milk, shin moisturizer, powder, perfumed soap, oil, dry powder, foundation emulsion, wet-milling or spray；
The present invention has the following advantages and effect relative to prior art：
(1) activity of fighting against senium compositions of the invention are reasonable due to arranging in pairs or groups, and science matched, with significant Synergistic
For effect, more single aging ingredient, effect substantially, using can reach obviously anti-aging effects, skin after 30 days
Become full, the young state of recovery of compacting.
(2) present invention by such skin makeup nutritional ingredient without injecting skin corium, and its is safe.
(3) the activity of fighting against senium compositions that the present invention is provided are used in cosmetics, can make gentle, stable and effect
Good skin anti-aging cosmetics.
Brief description of the drawings
Fig. 1 is that the common face cream of comparative example 2 uses skin surface figure preceding and using rear 30d, wherein, A：Before use；
B：After use.
Fig. 2 is that the anti-aging face cream of embodiment 7 uses skin surface figure preceding and using rear 30d, wherein, A：Before use；B：
After use.
Embodiment
With reference to embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited
In this.
In embodiment, large and small numerator sodium hyaluronate is purchased from Bloomage Freda Biopharm Co., Ltd.；Human epidermal growth
The factor and acetyl hexapeptide -8 are purchased from Guangzhou You Ran bio tech ltd；Carnosine is purchased from Symrise companies of Germany.
Embodiment 1
A kind of activity of fighting against senium compositions, include component as follows by mass percentage：
The preparation method of described activity of fighting against senium compositions, is comprised the following steps：
The each component of activity of fighting against senium compositions is well mixed, activity of fighting against senium compositions are obtained.
Embodiment 2
A kind of activity of fighting against senium compositions, include component as follows by mass percentage：
The preparation method of described activity of fighting against senium compositions, is comprised the following steps：
The each component of activity of fighting against senium compositions is well mixed, activity of fighting against senium compositions are obtained.
Embodiment 3
A kind of activity of fighting against senium compositions, include component as follows by mass percentage：
The preparation method of described activity of fighting against senium compositions, is comprised the following steps：
The each component of activity of fighting against senium compositions is well mixed, activity of fighting against senium compositions are obtained.
The skin nursing of embodiment 4 is prepared with anti-aging mask
A kind of skin nursing anti-aging mask of activity of fighting against senium compositions containing the embodiment of the present invention 3, it is formulated
Composition is shown in Table 1.
The skin nursing of 1 embodiment of table 4 is constituted with the formula of anti-aging mask
Preparation method is as follows：
(1) component A is put into agitated kettle, is heated to 55 DEG C, stirring is to being uniformly dissolved；
(2) 40 DEG C are cooled to, B phase components are added, dispersed with stirring is uniform；
(3) 400 mesh after 35 DEG C, repetition measurement pH are cooled to discharge, skin nursing anti-aging mask is obtained.
The preparation of the skin nursing of embodiment 5 anti-aging emulsion
A kind of skin nursing anti-aging emulsion of activity of fighting against senium compositions containing the embodiment of the present invention 1, its formula group
Into being shown in Table 2.
The skin nursing of table 2 is constituted with the formula of anti-aging emulsion
Preparation method is as follows：
(1) component A is put into dispersed with stirring at oil cauldron, 80 DEG C and uniformly, is used as oil phase；
(2) B component raw material is put into emulsification pot, dissolving is uniformly dispersed at 80 DEG C；
(3) oil phase is at the uniform velocity added in aqueous phase under agitation, time-consuming 3.0 minutes；After addition is finished, homogeneous speed
Emulsified again under 6000rpm 5.0 minutes, stirring 500rpm is opened in emulsification after terminating；
(4) 40 DEG C are cooled to component C is added into emulsification pot, stirred；
(5) stir, vacuumize, cool to 35 DEG C of dischargings, obtain skin nursing anti-aging emulsion.
The preparation of the skin nursing of embodiment 6 anti-aging eye cream
A kind of skin nursing anti-aging eye cream of activity of fighting against senium compositions containing the embodiment of the present invention 2, its formula group
Into being shown in Table 3.
The skin nursing of table 3 is constituted with the formula of anti-aging eye cream
Preparation method is as follows：
(1) component A is put into dispersed with stirring at oil cauldron, 80 DEG C and uniformly, is used as oil phase；
(2) B component raw material is put into emulsification pot, dissolving is uniformly dispersed at 80 DEG C；
(3) oil phase is at the uniform velocity added in aqueous phase under agitation, time-consuming 3.0 minutes；After addition is finished, homogeneous speed
Emulsified again under 6000rpm 5.0 minutes, stirring 500rpm is opened in emulsification after terminating；
(4) 40 DEG C are cooled to component C is added into emulsification pot, stirred；
(5) stir, vacuumize, cool to 35 DEG C of dischargings, obtain skin nursing anti-aging eye cream.
The preparation of the skin nursing anti-aging face cream of embodiment 7
A kind of skin nursing anti-aging face cream of the activity of fighting against senium compositions containing the embodiment of the present invention 3, its formula group
Into being shown in Table 4.
The formula composition of the skin nursing anti-aging face cream of table 4
Preparation method is as follows：
(1) component A is put into dispersed with stirring at oil cauldron, 80 DEG C and uniformly, is used as oil phase；
(2) B component raw material is put into emulsification pot, dissolving is uniformly dispersed at 80 DEG C；
(3) oil phase is at the uniform velocity added in aqueous phase under agitation, time-consuming 3.0 minutes；After addition is finished, homogeneous speed
Emulsified again under 6000rpm 5.0 minutes, stirring 500rpm is opened in emulsification after terminating；
(4) 40 DEG C are cooled to component C is added into emulsification pot, stirred；
(5) stir, vacuumize, cool to 35 DEG C of dischargings, obtain skin nursing anti-aging face cream.
The preparation of common anti-aging face cream of the comparative example 1 without Sodium Hyaluronate
A kind of activity of fighting against senium compositions without Sodium Hyaluronate, compared with Example 3, without Sodium Hyaluronate,
It is specific to include component as follows by mass percentage：
The preparation method of the described activity of fighting against senium compositions without Sodium Hyaluronate, is comprised the following steps：
The each component of the activity of fighting against senium compositions without Sodium Hyaluronate is well mixed, obtains being free of hyalomitome
The activity of fighting against senium compositions of sour sodium.
A kind of common anti-aging face cream without Sodium Hyaluronate, it is formulated composition and is shown in Table 5.
The formula composition of common anti-aging face cream of the table 5 without Sodium Hyaluronate
Preparation method is as follows：
(1) component A is put into dispersed with stirring at oil cauldron, 80 DEG C and uniformly, is used as oil phase；
(2) B component raw material is put into emulsification pot, dissolving is uniformly dispersed at 80 DEG C；
(3) oil phase is at the uniform velocity added in aqueous phase under agitation, time-consuming 3.0 minutes；After addition is finished, homogeneous speed
Emulsified again under 6000rpm 5.0 minutes, stirring 500rpm is opened in emulsification after terminating；
(4) 40 DEG C are cooled to component C is added into emulsification pot, stirred；
(5) stir, vacuumize, cool to 35 DEG C of dischargings, obtain the common anti-aging face without Sodium Hyaluronate
Frost.
The preparation of common face cream of the comparative example 2 without activity of fighting against senium compositions of the present invention
A kind of common face cream without activity of fighting against senium compositions of the present invention, it is formulated composition and is shown in Table 6.
The formula composition of the common face cream of table 6
Preparation method is as follows：
(1) component A is put into dispersed with stirring at oil cauldron, 80 DEG C and uniformly, is used as oil phase；
(2) B component raw material is put into emulsification pot, dissolving is uniformly dispersed at 80 DEG C；
(3) oil phase is at the uniform velocity added in aqueous phase under agitation, time-consuming 3.0 minutes；After addition is finished, homogeneous speed
Emulsified again under 6000rpm 5.0 minutes, stirring 500rpm is opened in emulsification after terminating；
(4) 40 DEG C are cooled to component C is added into emulsification pot, stirred；
(5) stir, vacuumize, cool to 35 DEG C of dischargings, obtain common face cream.
Effect example
(1) crease-resistant functional evaluation
In order to determine the senile-resistant efficacy of actual product, face cream made from embodiment 7 and comparative example 2 is surveyed
Examination.Skin matter is carried out by the eyes silicon northern blot of 10 healthy women volunteers to the process particular screen from the whole world
Analyze on ground.The silicon marking is before testing and by application acquisition twice daily in 30 days.The silicon marking passes through confocal scanning microscope point
Analysis, to assess the change of the front and rear skin surface for the treatment of.Skin surface image from optical three-dimensional reconstruction institute as shown in Figure 1, Figure 2
Show.It is observed that：Compared with comparative example 2, the wrinkle depth of 30 days significantly drops after face cream treatment made from embodiment 7
Low, skin becomes turgor.
(2) skin irritation test
The anti-aging face cream of Example 7, control sample is the face cream of comparative example 1 and comparative example 2, with 20 female
Property and 10 males be object, take 0.03ml samples to be placed in the coyote hole of spot examination adhesive tape with syringe, will be equipped with sample immediately
Spot tries adhesive tape longitudinal direction since bottom and is affixed on the normal skin of left forearm, while light pressing room and is made with driving away air one by one
Trier is uniformly distributed.Mark is carried out at experiment position, to observe.Every 24 hours patch skins once, open small half after paster
When, then checked according to the term of CTFA guides.6 patch experiments have been carried out altogether, have been pasted the 6th day after skin terminates, in order to
Delayed response is observed, additional inspection has been carried out.Data then utilize last time inspection result, compare.
The standard of perfection of skin irritation test is shown in Table 7：
The skin irritation test standard of perfection of table 7 is judged
Skin irritation test result see the table below 8：
The skin irritation test result of table 8
| Lagging number of times | Comparative example 1 | Comparative example 2 | Embodiment 7 |
| 1 | 0 | 0 | 0 |
| 2 | 0 | 0 | 0 |
| 3 | 0 | 0 | 0 |
| 4 | 0 | 0 | 0 |
| 5 | 0 | 0 | 0 |
| 6 | 0 | 0 | 0 |
| The 6th day after end | 0 | 0 | 0 |
| It is total | 0 | 0 | 0 |
As a result show, all no positive reaction of comparative example 1,2 products and the product of embodiment 7 occurs.Illustrate containing the present invention
The face cream of active compositions is non-stimulated to skin, no positive reaction.It is product safety, gentle.
(3) normal individual trial evaluation experimental
In order to evaluate product human body practical effect of the present invention, the anti-aging face cream of Example 7 is right as test specimen
Product are commercially available common anti-aging face cream and water laser accunputure in the same old way.Choose 30 usually have within 35~50 years old using anti-aging cream product and
Once there is the female consumer for trying out water laser accunputure to carry out product beta test evaluation test.Subject adheres to using product, 1 daily
Sensory effects evaluation is carried out to product after individual month, its result is as shown in table 9 below (to be counted, digitized representation more approves product per capita
The number of the assessment item)：
The sensory effects evaluation result of table 9
For the evaluation result of user can be seen that the relatively commercially available common anti-aging face cream of anti-aging face cream of the present invention
With more preferably mildness, the more gentle safety of hypodermic injection of the anti-aging face cream compared to water laser accunputure using external application is also considered as.
The product of embodiment 3 entirety anti-aging effects are better than commercially available prod, equally matched in water laser accunputure effect.Skin occurs obvious after 30 days
Sense of compacting, skin shine increase, wrinkle has obvious reduction.Most users' (66.7%) are all thought overall and used
Impression is better than control sample and water laser accunputure.
(4) moisture-keeping efficacy evaluation experimental
It is anti-ageing from embodiment 7 according to light industry standard QB/T 4256-2011 cosmetics moisture-keeping efficacy evaluation guides
Old face cream and the anti-aging face cream of comparative example 1, the common face cream of comparative example 2, determine its moistening effect.
Method of testing：Healthy volunteer 30, the age was at 20~50 years old.In isoperibol (22 ± 1 DEG C), relative humidity 50
± 5%, rest 1 hour after.By (2.0 ± 0.1) mg/cm2 consumption samples be coated in subject's left hand inner forearm (4cm ×
4cm) with (4cm × 4cm) on the inside of right forearm.Blank control (not applying) is tested simultaneously.Respectively be painted with sample 2 hours, 4
Hour, 6 hours, 8 hours test the hydrauture state of skin.Evaluation result is represented with hydrauture average value, is shown in Table 10 institutes
Show.
The moisture-keeping efficacy evaluation result of table 10
| Time | 2h hydrautures/% | 4h hydrautures/% | 6h hydrautures/% | 8h hydrautures/% |
| Embodiment 7 | 85.11 | 75.65 | 64.21 | 55.22 |
| Comparative example 1 | 68.25 | 49.21 | 42.98 | 40.19 |
| Comparative example 2 | 66.18 | 45.22 | 40.19 | 37.34 |
As a result show, the water skin of the product of embodiment 7 is right after 8h still 55.22%, and comparative example 1 and contrast are real
Apply skin hydration degree after the product 8h of example 2 and be reduced to 40.19% and 37.34%.Illustrate that the product of embodiment 7 has good long-acting moisturizing
Effect, better than the product of comparative example 1 and comparative example 2.There is skin higher hydrauture to be that skin keeps gloss to fill
The key being full of.
Above-described embodiment is preferably embodiment, but embodiments of the present invention are not by above-described embodiment of the invention
Limitation, other any Spirit Essences without departing from the present invention and the change made under principle, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of activity of fighting against senium compositions, it is characterised in that include component as follows by mass percentage：
2. activity of fighting against senium compositions according to claim 1, it is characterised in that comprising as follows by mass percentage
Component：
3. activity of fighting against senium compositions according to claim 2, it is characterised in that comprising as follows by mass percentage
Component：
4. the activity of fighting against senium compositions according to any one of claims 1 to 3, it is characterised in that：Described macromolecular
The mean molecule quantity of Sodium Hyaluronate is 1000000~1800000Da.
5. the activity of fighting against senium compositions according to any one of claims 1 to 3, it is characterised in that：Described small molecule
The mean molecule quantity of Sodium Hyaluronate is ＜ 10000Da.
6. application of the activity of fighting against senium compositions in cosmetic field described in any one of Claims 1 to 5.
7. application of the activity of fighting against senium compositions according to claim 6 in cosmetic field, it is characterised in that：
Described cosmetics are cosmetic preparation for skin care.
8. application of the activity of fighting against senium compositions according to claim 7 in cosmetic field, it is characterised in that：Institute
The consumption of anti-aging active matter composition is 1~10%w/w in the cosmetic preparation for skin care stated.
9. application of the activity of fighting against senium compositions according to claim 8 in cosmetic field, it is characterised in that：Institute
The consumption of anti-aging active matter composition is 5~10%w/w in the cosmetic preparation for skin care stated.
10. application of the activity of fighting against senium compositions according to claim 7 in cosmetic field, it is characterised in that：
The formulation of described cosmetic preparation for skin care be solution, suspension, emulsion, creme, paste, gel, milk, shin moisturizer,
Powder, perfumed soap, oil, dry powder, foundation emulsion, wet-milling or spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710364718.2A CN107115220A (en) | 2017-05-22 | 2017-05-22 | A kind of activity of fighting against senium compositions and preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710364718.2A CN107115220A (en) | 2017-05-22 | 2017-05-22 | A kind of activity of fighting against senium compositions and preparation method and application |
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| Publication Number | Publication Date |
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| CN107115220A true CN107115220A (en) | 2017-09-01 |
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ID=59727882
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108514519A (en) * | 2018-05-11 | 2018-09-11 | 珠海伊斯佳科技股份有限公司 | A kind of skin care compositions and methods and its application method of whitening and anti-aging |
| GB2572173A (en) * | 2018-03-21 | 2019-09-25 | Byrne Daniel | Personal cleaning composition |
| CN110464666A (en) * | 2019-09-12 | 2019-11-19 | 广州市科能化妆品科研有限公司 | Eye lip frost and preparation method thereof |
-
2017
- 2017-05-22 CN CN201710364718.2A patent/CN107115220A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2572173A (en) * | 2018-03-21 | 2019-09-25 | Byrne Daniel | Personal cleaning composition |
| GB2572173B (en) * | 2018-03-21 | 2021-10-06 | Byrne Daniel | Personal cleansing composition |
| CN108514519A (en) * | 2018-05-11 | 2018-09-11 | 珠海伊斯佳科技股份有限公司 | A kind of skin care compositions and methods and its application method of whitening and anti-aging |
| CN110464666A (en) * | 2019-09-12 | 2019-11-19 | 广州市科能化妆品科研有限公司 | Eye lip frost and preparation method thereof |
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Application publication date: 20170901 |