CN105342882B - A kind of compound moisturizing stoste of more effects and its application process - Google Patents
A kind of compound moisturizing stoste of more effects and its application process Download PDFInfo
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- CN105342882B CN105342882B CN201510742080.2A CN201510742080A CN105342882B CN 105342882 B CN105342882 B CN 105342882B CN 201510742080 A CN201510742080 A CN 201510742080A CN 105342882 B CN105342882 B CN 105342882B
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- polyglutamic acid
- hydrogel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/87—Polyurethanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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Abstract
The present invention provides a kind of compound moisturizing stoste of more effects and its application.The compound moisturizing stoste includes the polyglutamic acid or its salt of three kinds of molecular weight ranges, in addition also extremely strong, good film-forming property polyglutamic acid hydrogel or polyglutamic acid gel brine containing water imbibition.The compound moisturizing stoste all has superior moistening effect with human skin in vitro, and its ingredient is safe, and cell, animal, human body do not show toxicity and irritation.This compound moisturizing stoste can also be applied in a variety of cosmetics, can be prepared into lotion, cream, facial mask etc..
Description
Technical field
The invention belongs to cosmetic field, it is related to a kind of compound moisturizing stoste of more effects containing polyglutamic acid and its making
Method and application.
Background technology
The smooth skin of health is derived from effective moisturizing, and the moisturizing agent material for skin care item should not only have water absorbing capacity
Power will also have water holding capacity, to prevent moisture evaporation, and must have safety.Traditional moisturizer suitable for cosmetic industry
Including glycerine, sorbierite, sodium lactate, propylene glycol and amino acid etc..Water absorbability, safety and the stabilization of these moisturizer
Property limits its practical application effect, if although glycerine, sorbierite and propylene glycol have good water retention property, is but easy to cause shield
The stickiness of skin product enhances, and skin sense declines；Sodium lactate has preferable water holding capacity, but is difficult to emulsify in the formula of product；Thoroughly
Bright matter acid, collagen, poly-aspartate or amino-acid ester have good water holding capacity, but it is reducing the effect of water is evaporated from skin
It is relatively low, and viscosity can be shown in skin surface；It is evaporated from skin surface although saualane has moisture retention and can avoid water,
Its oiliness property makes user feel skin greasing.In order to reach the moisture-retaining capacity of comprehensive performance, existing skin care item are simultaneously
Use a variety of moisturizer.
With age, skin cell metabolism function is gradually reduced, and newborn collagen and hyaluronic acid decline,
And the degradation process of mentioned component is accelerated simultaneously, and dry skin, flexibility decrease, wrinkle is caused to increase.Due to environmental pollution and purple
Outside line is irradiated, and be easy to cause that the colour of skin is dimmed, and lackluster, color spot occurs in partial human face.For wrinkle and color spot, existing shield
Skin product mostly use chemicals, such as lactic acid helps to dispel cuticula and boost metabolism, and kojic acid has skin whitening
Effect.But the toxic side effect of chemicals is big, irritation is strong, and be difficult to achieve the purpose that treating both manifestation and root cause of disease.Therefore, searching can be with
The photosensitive cunning of imparting skin care item skin, the multifunctional efficient moisturizer not sticked together become skin care item industry urgent problem to be solved.
The molecular structure of polyglutamic acid and its salt polyhydroxy assigns its excellent water binding property and moisture-retaining capacity.Poly- paddy
The keratan (PCA), lactic acid (LA) and allantoin (UCA) equal size of skin inner layer can be improved in propylhomoserin and its salt, to realize from
Enhance its moisture-retaining capacity inside skin.The polyglutamic acid and its salt of low molecular weight can stimulate fibroblast to grow, and have
The effect of more obviously inhibiting melanin production, the polyglutamic acid of very low molecular weight are easier to penetrate epidermis flesh bottom.Wherein, at
Fibroblast participates in the process of the outer mechanism ingredient secretion of various kinds of cell, including collagen, Fibronectin, hyaluronic acid, sulphur
The Secretion regulation of aching and limp ossein, dermatan sulfate and elastin laminin etc..Therefore, polyglutamic acid and its salt also increase skin itself
The generation of the natural moisture preservings such as collagen, hyaluronic acid and elastin laminin, the tender factor.
The polyglutamic acid hydrogel and polyglutamic acid gel brine generated by ray or electron beam irradiation or chemical crosslinking
There are super water-absorbent and water holding capacity, and stickiness is smaller, can make skin care item that there is smooth touch and clean and tidy sense, easily be formed on the skin
Soft, smooth, mild film.The hydrogel has good biocompatibility, and being fixed on nutritional ingredient therein can be longer
Temporally keep biomolecule activity, hydrophilic small molecule that can be spread in hydrogel.Polyglutamic acid cross-linking products and poly- paddy
The cross-linking products of propylhomoserin salt have oil dispersed modification power, can reduce stickiness when skin care item use, and make oiliness therein
Ingredient is well merged with water composition.
Polyglutamic acid stoste of the present invention acts not only as moisture retention water exclusive use, can be used as other skin care item
It is formulated mother liquor, skin care item synergistic function is played, soft and fine smooth feeling is provided and improves skin health.
Invention content
It is an object of the present invention to provide a kind of more compound moisturizing stostes of effect, can be directed to existing skin care item moisturizing
The single disadvantage of ingredient viscosity, effect has intelligent moisturizing, water lock, whitening, promotion skin health and other effects.
Another object of the present invention is to provide a kind of compound moisturizing stoste of more effects and can be done directly on human skin
Surface acts on human skin surface for producing further cosmetics, and long-acting moisturizing promotes skin health.
Another object of the present invention is to provide a kind of compound moisturizing stoste of more effects in production or as in cosmetics
Application.
Technical scheme is as follows：A kind of compound moisturizing stoste of more effects, by weight percentage, specific formula group
Divide as follows：The polyglutamic acid of 500~2000kDa of average molecular weight or its salt 0.01%~5%, 50~500kDa of average molecular weight
Polyglutamic acid or its salt 0.01%~5%, the polyglutamic acid of 0.5~50kDa of average molecular weight or its salt 0.01%~5%,
Polyglutamic acid hydrogel or polyglutamic acid gel brine 0.1%~15%, surplus are solvent.
Each component is fully dissolved according to above-mentioned weight percent and is uniformly mixed, you can the compound moisturizing for obtaining the present invention is former
Liquid.
Preferably, polyglutamic acid or its salt are in the component：Polyglutamic acid sodium and/or polyglutamic acid potassium and/or poly- paddy
Propylhomoserin magnesium and/or polyglutamic acid calcium.
It is further preferred that polyglutamic acid or its salt are in the component：Polyglutamic acid sodium.
Preferably, polyglutamic acid hydrogel or polyglutamic acid gel brine are in the component：Polyglutamic acid sodium hydrogel
And/or polyglutamic acid potassium hydrogel and/or polyglutamic acid magnesium hydrogel and/or polyglutamic acid calcium hydrogel.
It is further preferred that polyglutamic acid hydrogel or polyglutamic acid gel brine are in the component：Polyglutamic acid sodium
Hydrogel.
Preferably, solvent is sterile water in the component.
The polyglutamic acid and its salt of three kinds of different molecular weights can be by natto extraction or microbial fermentation or chemical syntheses
Method is made, preferred microorganism fermentation；The hydrogel of the polyglutamic acid hydrogel and polyglutamate can be crosslinked by ray radiation
Or chemical reagent crosslinking is made, preferably chemical reagent is crosslinked.
The present invention also provides the compound moisturizing stostes of the more effects prepared according to the above technical scheme, by weight percentage, tool
Body recipe ingredient is as follows：The polyglutamic acid sodium 0.01%~5% of 500~2000kDa of average molecular weight, average molecular weight 50~
The polyglutamic acid sodium 0.01%~5% of 500kDa, the polyglutamic acid sodium 0.01%~5% of 0.5~50kDa of average molecular weight gather
Sodium glutamate hydrogel 0.1%~15%, surplus are sterile water.
The compound moisturizing stoste of described more effects can be used as the daily product that applies some make up, and directly act on human skin table
Face；Also after functional additive and customary adjuvant being added, it is fabricated to cosmetic product on demand, such as skin care water, cream, breast
Liquid, face cleaning product, facial mask, hair conditioner etc..When producing the cosmetics of above-mentioned form, the selection of other components can be in cosmetics
It is carried out according to the routine operation in this field；In production, by the compound moisturizing stoste of more effects of the present invention, functional additive
It is suitably added in solvent on demand with customary adjuvant, fully dissolves mixing.The addition ratio of more effect moisturizing stostes
Example is 10%~60%.
Preferably, the compound moisturizing stoste of described more effects be used for produce cosmetics in application, functional additive packet
It includes：Vitamins, amino acids, epidermal growth factor, plant extracts etc..
Preferably, the compound moisturizing stoste of described more effects be used for produce cosmetics in application, the routine of cosmetics is auxiliary
Material includes：As the oil phase component of solvent and emollient, such as mineral oil, wax, higher alcohol, aliphatic acid, different monooctyl ester, lanolin, hard
Resin acid etc.；Surfactant (anion, both sexes and nonionic), such as hydroxy sulfo lycine, single polyoxyethylene lauryl ether phosphorus
Acid esters sylvite, cocounut oil both sexes sodium acetate, alkyl glycosides etc.；Water phase components, such as water, glycerine, triethanolamine, potassium hydroxide；It is rich
Fat agent, such as olein, silicone emulsion；And antioxidant, chelating agent, preservative, fragrance etc..
Beneficial effects of the present invention are：
(1) polyglutamic acid or its salt, the polyglutamic acid hydrogel or polyglutamic acid gel brine that the present invention selects, has excellent
Biocompatibility, it is non-toxic, without skin irritation, it is safe to use.Using the polyglutamic acid of different molecular weight or its salt and
Hydrogel is combined, and is used directly as skin care item, and skin can be enabled to effectively absorb small molecule polyglutamic acid, promotes skin certainly
The natural skin-tenderings factor such as body collagen and hyaluronic acid generates, and makes the tender white health of skin, restores nature vigor；Have again stronger
Water lock ability and lubricity form one layer of air permeable humidity retaining film in skin surface, prevent evaporation of the moisture from epidermis, can also subtract
Few viscid sense makes skin have smooth feeling and clean and tidy sense, it is soft and flexible to assign skin；And polyglutamic acid can be given full play to
White-skinned face function, long-time service can also play mild whitening effect.
(2) application of a kind of more compound moisturizing stostes of effect provided by the invention in producing cosmetics, by with function
Property additive compound use, obtain significant cooperative synergism effect, increase the preserving moisture and protecting skin ability of product.
(3) present invention is simple for process using compound moisturizing stoste as cosmetic product stable quality made from raw material, suitable for work
Industry produces.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
A kind of more compound moisturizing stostes of effect of embodiment
A kind of more compound moisturizing stoste formulas of effect of Examples 1 to 8 are listed in table 1~2.
The formula of 1 Examples 1 to 4 of table
The formula of 2 embodiment 5~8 of table
Preparation process：By the formula ratio of 1~2 Examples 1 to 8 of table, average molecular weight of making even respectively be 500~2000kDa, 50
The polyglutamic acid sodium powder end of~200kDa, 0.5~50kDa are dissolved in appropriate amounts of sterilized water, mix well；Take polyglutamic acid sodium hydrogel
It is dissolved in appropriate amounts of sterilized water, is heated to 50 DEG C, abundant swelling mixing；Above-mentioned each ingredient is uniformly mixed, adds sterile water extremely
100%.
The compound moisturizing stoste of more effects of the present invention can be used as the daily product that applies some make up, and directly act on human skin table
Face；Also after functional additive and customary adjuvant being added, it is fabricated to cosmetic product on demand, such as skin care water, cream, breast
Liquid, face cleaning product, facial mask, hair conditioner etc..
The compound moisturizing stoste of more effects the answering in producing cosmetics further illustrated the present invention below by embodiment
With these embodiments are only intended to illustrate, are not limitations of the present invention.
A kind of whitening emulsion containing the more compound moisturizing stostes of effect of the present invention of embodiment 9
3 whitening emulsion prescription of table
Preparation process：(table 3) is designed according to prescription, component A in component table is heated to 75~80 DEG C, melt and is stirred
It is even；Component B is heated to 80~85 DEG C, and raw material is completely dissolved.A phase solution is added in B phase solution and stirs, after emulsification uniformly, simultaneously
Logical cooling water temperature is added the compound moisturizing stoste of more effects and fragrance and preservative, is stirred when temperature is down to 30 DEG C
Uniformly.
A kind of skin care cream containing the more compound moisturizing stostes of effect of the present invention of embodiment 10
4 skin care cream prescription of table
Preparation process：(table 4) is designed according to prescription, component A in component table is heated to 80 DEG C, melts and stirs evenly；
Component B is heated to 80 DEG C, dissolves and stirs evenly.A phase solution is added in B phase solution and stirs, and after emulsification uniformly, is cooled to 30 DEG C
When, the compound moisturizing stoste and fragrance and preservative of more effects is added, adjusts pH value 7.0, stirs evenly.
A kind of tax work facial mask containing the more compound moisturizing stostes of effect of the present invention of embodiment 11
Table 5 assigns facial mask liquid prescription living
Preparation process：It is arranged according to prescription (table 5), component A in component table is heated to 80 DEG C, dissolves and stirs evenly,
Then 40 DEG C are cooled to；B phase dissolution of raw material is stirring evenly and then adding into A phases, is uniformly mixed；When temperature is down to 30 DEG C,
The compound moisturizing stoste of more effects and fragrance and preservative is added, adjusts pH value 7.0, stirs evenly.
Experimental example efficacy test
The compound moisturizing stoste of above-described embodiment effect more than 1~8 is carried out safety and moisture retention test by 1.
(1) acute oral toxicity test of the more compound moisturizing stostes of effect of the present invention
Foundation《Cosmetics safety technical specification》Toxicological experiment method, it is primary or repeatedly orally administration is real in for 24 hours
After testing animal tested material, Health cost effect that animal occurs in a short time.It is using primary limitation method, i.e., oral with 10 cavys
5000mg/kg body weight doses detect whether to cause animal dead.
As a result：It contaminates in 1~7d times, no animal dead.Breathing, movement, eyes, hair, excreta are normal, without frightened
It faints no twitch.Animal appearance is checked every time, does not all observe signs of toxicity, is considered for animal welfare, it is not necessary that do substantially
Anatomic observation.It can be assumed that the compound moisturizing stoste of more effects of the present invention is without Oral toxicity.
(2) the acute dermal toxicity experiment of the more compound moisturizing stostes of effect of the present invention
Foundation《Cosmetics safety technical specification》Experimental method, after percutaneous primary coating tested material, statistical experiment animal
Death condition.Using primary limitation method, i.e., 2000mg/kg body weight doses is smeared with 10 guinea pig skins, detect animal dead feelings
Condition.And observe and record skin irritation/corrosion implementations.
As a result：It contaminates in 1~7d times, no animal dead.Breathing, movement, eyes, hair, excreta are normal, without frightened
It faints no twitch.Animal appearance is checked every time, does not observe signs of toxicity, is considered for animal welfare, it is not necessary that do substantially
Anatomic observation.It can be assumed that the compound moisturizing stoste of more effects of the present invention is without percutaneous toxicity.
(3) skin irritation test of the more compound moisturizing stostes of effect of the present invention
Foundation《Cosmetics safety technical specification》Experimental method, according to 2000mg/kg body weight doses apply tested material, see
Examine record skin irritation/corrosion implementations.The result shows that all animals do not observe skin irritatin phenomenon, i.e., it is of the invention
The compound moisturizing stoste of more effects without skin irritation.
(4) the external performance of keeping humidity of the more compound moisturizing stostes of effect of the present invention
The supersaturated solution that ammonium sulfate is placed in closed container drier, measuring relative air humidity in container is
55%, by medical air-permeable 3M tape-strippings on glass slide, adhesive tape is 6.7cm × 1.8cm, and 120 μ L tested materials are applied on adhesive tape.
Using deionized water as negative control, 5% glycerine is positive control, and each sample does 3 parallel repetitions.Distinguish at multiple time points
It weighs：Apply tested material before for M1, later M2, in drier place specific time after and 40% humidity environment place
It is Mn after 4h, calculates moisturizing rate and evaluate moistening effect.Moisturizing rate (%)=Mn/ (M2-M1) × 100%
The external moisturizing rate of the compound moisturizing stoste of table effect more than 6 changes with time
The result shows that (table 6)：1h, 2h, 4h moisturizing rate of calculating, polyglutamic acid sodium multifunctional efficient moisturizing stoste group data are equal
Higher than 5% glycerol and water.
(5) the human skin performance of keeping humidity of the more compound moisturizing stostes of effect of the present invention
25~40 years old healthy women volunteer 30 is chosen, measurement markers region is carried out in subject's both hands inner forearm,
Each Experimental Area size is 3cm × 3cm, and left arm applies 4% glycerine, 150 μ L as negative control, and right arm applies tested material 150
μL.With moisture of skin tester respectively measure smear sample before substrate value and smear sample 30,60,120,180min after it is tested
The skin moisture content in region, to evaluate the performance of keeping humidity of polyglutamic acid multifunctional efficient moisturizing stoste.Each parallel survey in region
5 times fixed, using average value as measurement data MMV values, test is completed by the same survey crew.To smear the work of the data before sample
For blank control, skin moisture content change rate calculation formula is as follows：MMV change rates=measured value/blank value × 100%.
The moistening effect of the table moisturizing stoste of effect more than 7 changes with time
The result shows that after (table 7), coating 30,60,120 and 180min, the MMV values of polyglutamic acid sodium stoste are above sweet
Oil.
Claims (7)
1. a kind of compound moisturizing stoste of more effects, by weight percentage, specific formula component is as follows：Average molecular weight 500~
The polyglutamic acid of 2000kDa or its salt 0.01%~5%, the polyglutamic acid of 50~500kDa of average molecular weight or its salt 0.01%
~5%, the polyglutamic acid of 0.5~50kDa of average molecular weight or its salt 0.01%~5%, polyglutamic acid hydrogel or polyglutamic
Hydrochlorate hydrogel 0.1%~15%, surplus are sterile water.
2. a kind of more compound moisturizing stostes of effect as described in claim 1, which is characterized in that in the component polyglutamic acid or
Its salt is polyglutamic acid sodium and/or polyglutamic acid potassium and/or polyglutamic acid magnesium and/or polyglutamic acid calcium.
3. a kind of more compound moisturizing stostes of effect as described in claim 1, which is characterized in that polyglutamic sour water in the component
Gel or polyglutamic acid gel brine are polyglutamic acid sodium hydrogel and/or polyglutamic acid potassium hydrogel and/or polyglutamic acid magnesium
Hydrogel and/or polyglutamic acid calcium hydrogel.
4. a kind of more compound moisturizing stostes of effect as described in claim 1, which is characterized in that by weight percentage, specifically
Recipe ingredient is as follows：The polyglutamic acid sodium 0.01%~5% of 500~2000kDa of average molecular weight, average molecular weight 50~
The polyglutamic acid sodium 0.01%~5% of 500kDa, the polyglutamic acid sodium 0.01%~5% of 0.5~50kDa of average molecular weight gather
Sodium glutamate hydrogel 0.1%~15%, surplus are sterile water.
5. a kind of more compound moisturizing stostes of effect as described in Claims 1 to 4 is any are in production or as answering in cosmetics
With.
6. a kind of application of more compound moisturizing stostes of effect as claimed in claim 5, which is characterized in that the functional addition of addition
After agent and customary adjuvant, it is fabricated to cosmetic product, including skin care water, cream, lotion, face cleaning product, facial mask, shield on demand
Hair element.
7. a kind of application of more compound moisturizing stostes of effect as claimed in claim 5, which is characterized in that with weight percent
Meter, the compound moisturizing stoste adding proportion of described more effects are 10%~60%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106265329A (en) * | 2016-09-07 | 2017-01-04 | 山东省药学科学院 | A kind of conditioner and application thereof |
| CN107802894A (en) * | 2017-10-11 | 2018-03-16 | 广州新诚生物科技有限公司 | A kind of bio-medical gel and preparation method thereof |
| CN108836979A (en) * | 2018-05-31 | 2018-11-20 | 哈尔滨运美达生物科技有限公司 | A kind of preparation method of sodium hyaluronate reparation patch and reparation patch and reparation patch Essence |
| CN109908015B (en) * | 2019-03-26 | 2021-11-12 | 山东省药学科学院 | Anti-allergy repairing and moisturizing composition and preparation method and application thereof |
| CN110075006B (en) * | 2019-04-19 | 2022-02-25 | 华熙生物科技股份有限公司 | Method for promoting solution compatibility of hyaluronic acid type substance and type II collagen and composition containing the same |
| CN110151659B (en) * | 2019-07-02 | 2020-05-26 | 泉后(广州)生物科技研究院有限公司 | External skin moisturizing composition, facial mask and preparation process thereof |
| CN113274314B (en) * | 2021-05-07 | 2023-02-03 | 山东省药学科学院 | Application of salt-sensitive hydrogel as intelligent water control and water supplement material |
| CN114081851A (en) * | 2021-11-01 | 2022-02-25 | 苏州纳美特生物科技有限公司 | Moisture-keeping spray |
| CN114699338B (en) * | 2022-04-14 | 2023-10-03 | 华熙生物科技股份有限公司 | Skin care composition and application and skin care product thereof |
| CN115317405A (en) * | 2022-05-07 | 2022-11-11 | 南京博盈新材料科技有限公司 | Application of multiple polyglutamic acid cross-linked polymer in skin repair |
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| CN103800219A (en) * | 2012-11-08 | 2014-05-21 | 山东福瑞达生物科技有限公司 | Multifunctional high-efficiency moisturizing stock solution |
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| JP2004210700A (en) * | 2002-12-27 | 2004-07-29 | Ichimaru Pharcos Co Ltd | Composition for treating hair |
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| CN1803124B (en) * | 2005-01-12 | 2010-04-21 | 东海生物科技股份有限公司 | Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof |
| CN103800219A (en) * | 2012-11-08 | 2014-05-21 | 山东福瑞达生物科技有限公司 | Multifunctional high-efficiency moisturizing stock solution |
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