CN109846740A - Skin care compositions and methods and its preparation method and application - Google Patents
Skin care compositions and methods and its preparation method and application Download PDFInfo
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- CN109846740A CN109846740A CN201910092986.2A CN201910092986A CN109846740A CN 109846740 A CN109846740 A CN 109846740A CN 201910092986 A CN201910092986 A CN 201910092986A CN 109846740 A CN109846740 A CN 109846740A
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Abstract
The invention belongs to cosmetic fields, a kind of skin care compositions and methods and its preparation method and application are provided, the composition is on the basis of composition weight 100%, include following components: pyruvic acid and its salt 0.001~20% (w/w), ketone valeric acid and its derivative 0.001~15% (w/w), moisturizer 65~90% (w/w).Composition oxidation resistance of the invention greatly promotes, and has the ability for repairing damage, and can effectively improve skin exsiccosis.
Description
Technical field
The invention belongs to cosmetic fields, are related to the composition of skin nursing.
Background technique
The many reasons such as environmental pollution, ultraviolet light irradiation, operating pressure will lead to skin injury, water shortage, oxidation, sensitivity,
The problems such as wrinkle, so that requirement of the people for skin nursing is higher and higher.
With the continuous development that beautifying skin, fine chemistry industry and cosmetics are researched and developed, the cosmetics in Modern Significance are (especially
It is to repair class skin care item) it is not limited solely to carry out skin the modification beautification of simple smell or color, also impart makeup
The more both effectiveness and safeties of product.For example, certain effective components in cosmetics, which can penetrate cuticula, enters skin, pass through
The structure and function for changing skin has the function that repair skin barrier.But since idea of the people to skin care is more careful, make
Must have the exploitation of the cosmetics of different function still has very large space.
Summary of the invention
The purpose of the present invention, is to provide a kind of composition of skin nursing, and composition includes pyruvic acid and its salt, ketone valeric acid
And its derivative, moisturizer, the problems such as skin injury, water shortage, oxidation, sensitivity, wrinkle can be effectively improved.The present invention by with
Lower scheme is realized.
A kind of skin care compositions and methods include following components on the basis of composition weight 100%:
Pyruvic acid and its salt 0.001~20% (w/w)
Ketone valeric acid and its derivative 0.001~15% (w/w)
Moisturizer 65~90% (w/w).
The pyruvic acid and its salt is selected from pyruvic acid, Sodium Pyruvate, Potassium pyruvate, pyruvic acid magnesium, CALCIUM PYRUVIC, acetone
It is one or more in sour zinc, methyl pyruvate；Preferably, pyruvic acid and its salt are pyruvic acid, in Sodium Pyruvate, Potassium pyruvate
It is one or more；
The ketone valeric acid and its derivative are selected from α-ketoglutaric acid, β -one glutaric acid, 5-ALA, δ-amino-
One of gamma-Ketovaleric acid is a variety of；
The moisturizer be selected from hyaluronic acid, ceramide, allantoin, trehalose, pyrrolidone sodium carboxylate, glycerol,
One of propylene glycol is a variety of；Preferably, moisturizer be hyaluronic acid, ceramide, allantoin, pyrrolidone sodium carboxylate,
One of glycerol is a variety of；
Preferably, on the basis of composition weight 100%, the composition includes:
Pyruvic acid and its salt 10~20% (w/w)
Ketone valeric acid and its derivative 5~15% (w/w)
Moisturizer 65~85% (w/w).
Pyruvic acid is small organic molecule important in biosystem, plays important pivotal role in three big metabolisms,
It is highly-safe.Sodium Pyruvate is the most common acetonate, and Sodium Pyruvate can directly remove oxygen radical in tissue, promotes cell
Oxidation resistance significantly improves cellular redox state, prevents cytoplasm vacuolization, maintains cell membrane integrity；In addition, third
Ketone acid sodium is as cytotrophy agent, additionally it is possible to repair damaged cell.
In ketone valeric acid and its derivative, α-ketoglutaric acid participates in tricarboxylic acid cycle in organism, generates amino acid, safety
It is high.α-ketoglutaric acid can be used as cosmetic composition as nutrient drug, can have battalion to facial skin cell by facial percutaneous absorption
Function is supported, and can have in conjunction with intracellular excessive nitrogen and remove free radical, desalination chloasma, delay senescence and other effects.
Hyaluronic acid is distributed widely in partes corporis humani position, and skin also contains a large amount of hyaluronic acid.Human skin maturation and
Ageing process also with hyaluronic acid content and metabolism and change, it can improve skin-nourishing be metabolized, keep skin soft
It is tender, smooth, go wrinkle, increase elasticity, prevent aging, be good skin penetration enhancer again while moisturizing.
Ceramide be lipoid between being present in the outermost corneocyte of human skin main composition (>
50%) important function for preventing moisture from distributing and protecting outside stimulus, is played, protection skin is carry and is moistened, moisturizing function
Energy.Ceramide is a kind of water-soluble lipid matter, and the water that can be penetrated into quickly in skin and cuticula combines, and forms one kind
Reticular structure locks moisture.Using the cosmetics containing ceramide, skin anti-aging function can be reinforced, skin is enabled to keep elasticity,
It is smooth careful, it reduces facial wrinkles and is formed.
Allantoin can promote cell growth, promote cell metabolism, accelerate wound healing, cutin-softening albumen, be
A kind of amphoteric compound, can in conjunction with many kinds of substance formed double salt, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation, can make
Skin locks moisture, keeps moist and soft, is the additive of cosmetics.
Pyrrolidone sodium carboxylate is naturally occurring material in skin, is amino acid derivativges, moisture retention height, stability
It is good, there is no irritation to skin and eyes, pore will not be blocked, it is highly-safe, it is that modern age skin or hair care is preferably naturally changed
Adornment health care product can make skin, hair have wetability, flexibility, elasticity and glossiness, antistatic property.Pyrrolidone sodium carboxylate
It is also excellent skin whitener, has inhibiting effect to the activity of tyrosinase related protein2, " melanoid " can be prevented to sink in skin
Product, to keep skin pure white.
In the second aspect, the preparation method of composition of the invention is provided, including the component is mixed by regulation content
It closes.
In the third aspect, composition of the invention is provided and is preparing the application in skin care item, wherein the skin care item are
Facial mask, toner, Essence, lotion, skin cream, eye cream or lipstick.The skin care item can be used for face, eye circumference, trick or body
Other required positions of body, the problems such as to improve skin injury, water shortage, oxidation, sensitivity, wrinkle, aging.
4th aspect provides a kind of skin care item, and the skin care item include composition of the invention, and the composition is protecting
Mass content in skin product is 2~15%.
Preferably, the skin care item also include surfactant, pH adjusting agent, complexing agent, preservative, antioxidant, solubilising
One of agent, defoaming agent, emulsifier, skin emollient, thickener, moisturizer, essence and solvent are a variety of.
Preferably, the skin care item are aqua, creme, emulsion, pulvis.It is further preferred that the skin care item be facial mask,
Toner, Essence, lotion, skin cream, eye cream or lipstick.
Composition of the invention combines pyruvic acid and its salt, ketone valeric acid and its derivative and moisturizer use, makes
The oxidation resistance for obtaining pyruvic acid and its salt, ketone valeric acid and its derivative combination greatly promotes, and synergistic effect is significant, and the two is equal
For intracellular nutritional substance, the ability of damage is more repaired, at the same time, moisturizer is added, and can increase the water lock energy of cell
Power, the problems such as being effectively improved skin water shortage, and the water and oil balance of adjustable skin restore elasticity of skin, delay senescence etc..
Specific embodiment
Below in conjunction with specific embodiment, the present invention is described further, but the scope of the invention is not limited to following implementation
Example, any equivalence changes based on the basis of technical solution of the present invention are all fallen within the protection scope of the present invention.
In following embodiment, not clearly stating such as, the reagent and instrument used is all this field conventional reagent and instrument,
It can be obtained by commercially available mode, used method is all conventional method in that art, and those skilled in the art are according to embodiment
Content can unambiguously complete the experiment and obtain corresponding result.
Embodiment 1: the preparation of facial mask
By preparing the skin care item of the present embodiment according to the formula in table 1, and prepare facial mask.
Table 1: embodiment 1 is formulated
Preparation steps are as follows:
[1] purified water of recipe quantity 80% is added in Agitation Tank；
[2] Sodium Pyruvate, α-ketoglutaric acid, ceramide, hyaluronic acid, glycerol, EDTA-2Na is added to stir to complete
Dissolution；
[3] after dissolving Cremophor RH40 with a small amount of water heating stirring, Phenoxyethanol, methyl hydroxybenzoate, perfume (or spice) is added
Essence is added in above-mentioned solution after stirring and dissolving；
[4] pH value of solution is adjusted to 6.0-7.0 with triethanolamine；
[5] be added purified water to recipe quantity to get.
Face paper is soaked in above-mentioned solution, is encapsulated.
Embodiment 2: the preparation of essence lotion
The essence lotion of the present embodiment is prepared according to the formula of table 2:
Table 2: the formula of embodiment 2
The preparation steps of embodiment 2 are as follows:
[1] purified water of recipe quantity 80% is added in Agitation Tank；
[2] Sodium Pyruvate, α-ketoglutaric acid, pyrrolidone sodium carboxylate, hyaluronic acid, adenosine, ascorbic acid grape is added
Glucosides, glycerol, EDTA-2Na, hydroxyethyl piperazine ethane sulfonic acid are stirred to being completely dissolved；
[3] after dissolving PEG-20 methyl sesquistearate with a small amount of water, dimethyl silicone polymer, benzene oxygen is added
Ethyl alcohol is added in above-mentioned solution after heating stirring dissolution；
[4] solution PH is adjusted to 6.0-7.0 with sodium citrate；
[5] addition purified water is filling to formula ratio.
Embodiment 3: the preparation of creams
The skin care item of the present embodiment are prepared according to the formula of table 3.
Table 3: the formula of embodiment 3
The preparation steps of embodiment 3 are as follows:
[1] purified water of formula ratio is added in Agitation Tank, Sodium Pyruvate, α-ketoglutaric acid, 2-pyrrolidone-5-carboxylic acid is added
Sodium, allantoin, glycerol, triethanolamine stirring and dissolving, obtain aqueous phase solution；
[2] it is poly- that tristerin, dimethyl silicone polymer, cetostearyl alcohol, ethylhexyl palmitate, PEG-10 is added
Dimethyl siloxane, polysiloxanes -8, Phenoxyethanol, distearyl dimethylammonium hectorite, tocopherol acetate heating stirring are extremely
It is completely dissolved, obtains oil-phase solution；
[3] oil-phase solution is added in aqueous phase solution, while carries out high shear homogenized milk agent and just emulsifies；[4] will
Obtained creams carry out filling.
Embodiment 4: the preparation of lotion
Lotion is prepared according to the formula of table 4.
Table 4: the formula of lotion
The preparation steps of embodiment 4 are as follows:
[1] purified water of formula ratio is added in Agitation Tank, Sodium Pyruvate, α-ketoglutaric acid, 2-pyrrolidone-5-carboxylic acid is added
Sodium, Sodium Hyaluronate, propylene glycol, polypropylene acyl group dimethyl disulfide ichthyodin, triethanolamine stirring and dissolving, obtain aqueous phase solution；
[2] be added phosphatide, tristerin, dimethyl silicone polymer, cetostearyl alcohol, ethylhexyl palmitate,
PEG-100 stearate, polysiloxanes -8, tocopherol, Phenoxyethanol heating stirring obtain oil-phase solution to being completely dissolved；
[3] it is added in aqueous phase solution with oil-phase solution, while carrying out high shear homogenized milk agent and just emulsifying；
[4] obtained lotion is carried out filling.
Embodiment 5: the moisture-keeping function test of product
30 volunteers are given to use respectively in the sample of embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 1 is
It uses 3 times weekly, is used continuously 1 month, embodiment 2,3,4 is to use 1 time sooner or later daily, is used continuously one month, during which stops
Only use other skin type products.
The skin before and after volunteer tests is measured respectively using JC08-SHM100 skin oil and fat moisture content melanin tester to contain
Water degree, average data are as follows:
Table 5: product moisture-keeping function result
| Test group | Aqueous degree before testing | Aqueous degree after test |
| Embodiment 1 | 28.3±2.3 | 48.8±3.1 |
| Embodiment 2 | 30.1±1.8 | 55.2±2.7 |
| Embodiment 3 | 30.6±1.6 | 59.0±2.9 |
| Embodiment 4 | 29.2±2.1 | 58.4±3.0 |
Thus data are it is found that embodiment 1,2,3,4 all shows good skin moisture-keeping effect.
Embodiment 6: the antioxidant effect test of product
Table 6: control group of formula
Control group composition is prepared according to table 6, wherein the formula of control group A is to be not added with Sodium Pyruvate and α -one penta 2
Acid, rest materials and dosage and embodiment 1 are consistent；The formula of control group B is to be not added with Sodium Pyruvate, rest materials and dosage with
Embodiment 1 is consistent；The formula of control group C is to be not added with α-ketoglutaric acid, rest materials and dosage and embodiment 1 unanimously.Control
The preparation process of A, control group B, control group C are organized with embodiment 1.
The free radical scavenging ability for comparing the sample of control group A, control group B, control group C and embodiment 1, in conjunction with hydroxyl freedom
Base Scavenging activity measuring method (DPPH method) detects that the free radical scavenging activity of control group A is 5.1%, and the free radical of control group B is clear
Except rate is 11.6%, the free radical scavenging activity of control group C is 20.3%, and the free radical scavenging activity of embodiment 1 is 39.4%.Implement
The free radical scavenging activity of example 1 is 6.96 times of control group A, illustrates that the oxidation resistance of composition is far longer than and does not add pyruvic acid
And its salt, ketone valeric acid and its derivative；The free radical scavenging activity of embodiment 1 much larger than control group B and control group C numerical value it
With illustrate that the antioxidant capacity of composition is also significantly better than and pyruvic acid and its salt be only added or is only added ketone valeric acid and its derivative
Thus object can illustrate, pyruvic acid and its salt, ketone valeric acid and its derivative are combined use, and oxidation resistance mentions significantly
It rises.In conjunction with moisturizer, the water lock ability of cell is increased, skin water shortage problem is effectively improved.
Claims (10)
1. a kind of skin care compositions and methods include following components on the basis of composition weight 100%:
Pyruvic acid and its salt 0.001~20% (w/w)
Ketone valeric acid and its derivative 0.001~15% (w/w)
Moisturizer 65~90% (w/w).
2. skin care compositions and methods according to claim 1, wherein on the basis of composition weight 100%, the combination
Object includes:
Pyruvic acid and its salt 10~20% (w/w)
Ketone valeric acid and its derivative 5~15% (w/w)
Moisturizer 65~85% (w/w).
3. skin care compositions and methods according to claim 1 or 2, wherein
The pyruvic acid and its salt be selected from pyruvic acid, Sodium Pyruvate, Potassium pyruvate, pyruvic acid magnesium, CALCIUM PYRUVIC, pyruvic acid zinc,
It is one or more in methyl pyruvate；
The ketone valeric acid and its derivative are selected from α-ketoglutaric acid, β -one glutaric acid, 5-ALA, delta-amino-gamma -one penta
One of acid is a variety of；
The moisturizer is selected from hyaluronic acid, ceramide, allantoin, trehalose, pyrrolidone sodium carboxylate, glycerol, propylene glycol
One of or it is a variety of.
4. a kind of skin care item, the skin care item include the described in any item compositions of claims 1 to 3, and the composition is protecting
Mass content in skin product is 2~15%.
5. skin care item according to claim 4, wherein the skin care item also include surfactant, pH adjusting agent, complexing
In agent, preservative, antioxidant, solubilizer, defoaming agent, emulsifier, skin emollient, thickener, moisturizer, essence and solvent
It is one or more.
6. skin care item according to claim 5, the skin care item are aqua, creme, emulsion or pulvis.
7. skin care item according to claim 6, wherein the skin care item are facial mask, toner, Essence, lotion, moisturizing
Frost, eye cream or lipstick.
8. the preparation method of the described in any item compositions of claims 1 to 3, including the component is mixed by regulation content.
9. the described in any item compositions of claims 1 to 3 are preparing the application in skin care item.
10. application according to claim 9, wherein the skin care item are facial mask, toner, Essence, lotion, moisturizing
Frost, eye cream or lipstick.
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Cited By (5)
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| CN111265505A (en) * | 2020-03-09 | 2020-06-12 | 上海中医药大学附属岳阳中西医结合医院 | New application of pyruvic acid |
| CN112370415A (en) * | 2020-11-24 | 2021-02-19 | 杭州百芮生物科技有限公司 | Quick-acting pore-shrinking composition and preparation method thereof |
| CN113491644A (en) * | 2020-04-01 | 2021-10-12 | 株式会社爱茉莉太平洋 | Additive composition and use of pyruvic acid or pyruvate |
| CN114081851A (en) * | 2021-11-01 | 2022-02-25 | 苏州纳美特生物科技有限公司 | Moisture-keeping spray |
| CN115813784A (en) * | 2022-11-28 | 2023-03-21 | 麦吉丽生物科技有限公司 | Application of alpha-ketoglutaric acid and rice fermentation liquor containing alpha-ketoglutaric acid in preparation of skin inflammation inhibitor |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265505A (en) * | 2020-03-09 | 2020-06-12 | 上海中医药大学附属岳阳中西医结合医院 | New application of pyruvic acid |
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| CN112370415A (en) * | 2020-11-24 | 2021-02-19 | 杭州百芮生物科技有限公司 | Quick-acting pore-shrinking composition and preparation method thereof |
| CN112370415B (en) * | 2020-11-24 | 2022-04-22 | 杭州百芮生物科技有限公司 | Quick-acting pore-shrinking composition and preparation method thereof |
| CN114081851A (en) * | 2021-11-01 | 2022-02-25 | 苏州纳美特生物科技有限公司 | Moisture-keeping spray |
| CN115813784A (en) * | 2022-11-28 | 2023-03-21 | 麦吉丽生物科技有限公司 | Application of alpha-ketoglutaric acid and rice fermentation liquor containing alpha-ketoglutaric acid in preparation of skin inflammation inhibitor |
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| CN109846740B (en) | 2022-05-17 |
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Address after: 225300 No.1, South Batang Road, China medicine city, Taizhou City, Jiangsu Province Patentee after: Jiangsu Changtai Pharmaceutical Co.,Ltd. Address before: 225300 No.1, South Batang Road, China medicine city, Taizhou City, Jiangsu Province Patentee before: JIANG SU PHARMAMAXCORP Co.,Ltd. |