JP5241054B2 - Composition for promoting collagen synthesis - Google Patents
Composition for promoting collagen synthesis Download PDFInfo
- Publication number
- JP5241054B2 JP5241054B2 JP2004052661A JP2004052661A JP5241054B2 JP 5241054 B2 JP5241054 B2 JP 5241054B2 JP 2004052661 A JP2004052661 A JP 2004052661A JP 2004052661 A JP2004052661 A JP 2004052661A JP 5241054 B2 JP5241054 B2 JP 5241054B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- acid
- collagen synthesis
- composition
- ascorbic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Description
本発明は、アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種(以下、本明細書においてこれらを総称して「アスコルビン酸類」ともいう。)と、低分子ベタインとからなるコラーゲン合成促進剤に関する。 The present invention relates to at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives and salts thereof (hereinafter collectively referred to as “ascorbic acids” in the present specification), low molecular betaine, It is related with the collagen synthesis promoter which consists of.
コラーゲンは、動物の結合組織を構成する主要蛋白質であり、特にヒトの体の総蛋白質の30%近くをコラーゲンが占める。コラーゲンの主たる機能は、生体組織の骨格構造の形成にあるので、動物の組織形態の骨格構造を構成する主成分として皮膚、軟骨組織、角膜、心臓、肝臓等に広く分布する。コラーゲンは、各種細胞の接着、細胞の分化や増殖に対して特異的に作用し、細胞機能の調節因子としての役割も持っているため、コラーゲンの減少は、角膜潰瘍等の角膜障害、リューマチ、関節炎、変形性関節炎、骨関節炎等の関節障害、炎症性疾患等の様々な疾患を引き起こすことがある。 Collagen is a major protein that constitutes the connective tissue of animals, and collagen occupies nearly 30% of the total protein of the human body. Since the main function of collagen is in the formation of a skeletal structure of living tissue, it is widely distributed in skin, cartilage tissue, cornea, heart, liver, etc. as the main component constituting the skeletal structure of animal tissue form. Collagen acts specifically on cell adhesion, cell differentiation and proliferation, and also has a role as a regulator of cell function. Collagen reduction is caused by corneal disorders such as corneal ulcer, rheumatism, It may cause various diseases such as arthritis, osteoarthritis, joint disorders such as osteoarthritis, and inflammatory diseases.
皮膚真皮細胞外マトリックスでは、コラーゲン繊維が網目状の束を形成することにより組織形態を維持している。コラーゲン繊維は、成熟し増殖して架橋形成が進行すると太く直線的な繊維束となり、若い皮膚での適度なハリを与えている。しかし、老化した皮膚では繊維芽細胞の活性が低下するのに伴い、真皮細胞外マトリックスのコラーゲン繊維が著しく減少したり、異常な老化架橋が形成されるため硬直して、本来の弾力性に富むハリが失われてしまう。その結果、皮膚にはシワやタルミが形成される。光老化によるヘアレスマウス繊維束構造の変化が詳細に検討され(Fragrance Journal、4、p36-37、1998)、UVBを照射したヘアレスマウスには、シワが形成され、シワの形成と一致するようにコラーゲン繊維束構造が崩壊し皮膚弾力性が低下していくことが示されている。また、コラーゲンは水分保持機能に優れていることも知られている。 In the cutaneous dermal extracellular matrix, collagen fibers form a mesh-like bundle to maintain the tissue morphology. Collagen fibers become thick and linear fiber bundles when they mature and proliferate and crosslink formation proceeds, giving moderate tension on young skin. However, in aging skin, as fibroblast activity decreases, collagen fibers in the dermal extracellular matrix are remarkably reduced and abnormal aging crosslinks are formed, making it stiff and rich in its original elasticity. The tension will be lost. As a result, wrinkles and tarmi are formed on the skin. Changes in the fiber bundle structure of hairless mice due to photoaging have been studied in detail (Fragrance Journal, 4, p36-37, 1998), so that wrinkles are formed in hairless mice irradiated with UVB, which is consistent with the formation of wrinkles. It has been shown that the collagen fiber bundle structure collapses and the skin elasticity decreases. It is also known that collagen is excellent in water retention function.
コラーゲンの減少による状態を改善するために、種々のコラーゲン合成促進物質が見出されている。例えば、レチノイン酸(非特許文献1)、グリシン及びプロリン及びアラニンからなる3種アミノ酸(特許文献1)、カンゾウ、ソウハクヒ、アロエ、スギナ、キンギンカ、オウバク、ガイヨウ又はゲンチアナなどの植物抽出物(特許文献2)、TGF−β、アスコルビン酸類等が知られている。アスコルビン酸類にはコラーゲン等の生体成分の合成促進による細胞賦活効果がある。 In order to improve the state caused by the decrease in collagen, various collagen synthesis promoting substances have been found. For example, plant extracts such as retinoic acid (Non-patent Document 1), three kinds of amino acids consisting of glycine, proline, and alanine (Patent Document 1), licorice, Sakuhakuhi, Aloe, Sugina, Goldwing, Oat, Guiyou, or Gentian 2) TGF-β, ascorbic acids and the like are known. Ascorbic acids have a cell activation effect by promoting the synthesis of biological components such as collagen.
ところで、トリメチルグリシンに代表される低分子ベタインは、保湿剤として皮膚外用剤に広く用いられており、例えば、尿素と低分子ベタインとの併用により、格段に優れた肌荒れ改善効果が得られること(特許文献3)、美白成分、低分子ベタイン、シリコーン油を配合することにより、美白剤の経皮吸収性が向上すること(特許文献4)等が知られている。 By the way, low molecular weight betaine typified by trimethylglycine is widely used as a moisturizer in a topical skin preparation. For example, the combined use of urea and low molecular weight betaine can provide an extremely excellent rough skin improvement effect ( Patent Document 3), whitening ingredients, low molecular weight betaine, and silicone oil are known to improve the transdermal absorbability of whitening agents (Patent Document 4).
本発明の課題は、安全性が高く優れたコラーゲン合成促進剤を提供することにある。 An object of the present invention is to provide an excellent collagen synthesis accelerator having high safety.
本発明者は、アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種と、低分子ベタインを配合することによって相乗的なコラーゲン合成促進作用を奏することを見い出し、発明を完成させるに至った。 The present inventor has found that synergistic collagen synthesis promoting action is achieved by blending at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives and salts thereof, and low molecular weight betaine. It came to complete.
すなわち、本発明は下記に掲げる発明である。
(1)アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種並びに、低分子ベタインを有効成分として含有するコラーゲン合成促進剤、
(2)アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種並びに、低分子ベタインを含有するコラーゲン合成促進用組成物、
(3)コラーゲン合成促進用組成物が、抗シワ用組成物、抗タルミ用組成物、関節障害の予防又は治療用組成物、炎症性疾患の予防又は治療用組成物である(2)に記載のコラーゲン合成促進用組成物、
(4)アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種並びに、低分子ベタインをコラーゲン合成促進剤として含有する(2)に記載のコラーゲン合成促進用組成物、
(5)アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種1重量部に対して低分子ベタインを0.001〜100重量部となるように含有することを特徴とする(2)に記載のコラーゲン合成促進用組成物、
(6)アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種と、低分子ベタインを併用することによって、細胞でのコラーゲン合成量を増加させる方法。
That is, this invention is the invention hung up below.
(1) a collagen synthesis promoter containing ascorbic acid, at least one selected from the group consisting of ascorbic acid derivatives and salts thereof, and a low-molecular-weight betaine as an active ingredient,
(2) a composition for promoting collagen synthesis, comprising at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives and salts thereof, and low molecular betaine;
(3) The composition for promoting collagen synthesis is an anti-wrinkle composition, an anti-tarmi composition, a composition for preventing or treating joint disorders, and a composition for preventing or treating inflammatory diseases. A composition for promoting collagen synthesis,
(4) The composition for promoting collagen synthesis according to (2), comprising at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives and salts thereof, and low molecular betaine as a collagen synthesis promoter,
(5) The low-molecular-weight betaine is contained so that it may become 0.001-100 weight part with respect to at least 1 sort (s) 1 weight part selected from the group which consists of ascorbic acid, an ascorbic acid derivative, and those salts. The composition for promoting collagen synthesis according to (2),
(6) A method for increasing the amount of collagen synthesis in cells by using at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives and salts thereof and low molecular betaine.
本発明によって、アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選択される少なくとも1種と、低分子ベタインを有効成分として含有するコラーゲン合成促進剤を提供できる。また、アスコルビン酸類と、低分子ベタインを共に用いることによって、細胞でのコラーゲン合成量を顕著に増加させることができる。さらに、アスコルビン酸類並びに、低分子ベタインを含有するコラーゲン合成促進用組成物は、コラーゲン減少を防止し、抗シワ用組成物、抗タルミ用組成物、関節障害の予防又は治療用組成物、炎症性疾患の予防又は治療用組成物として有用である。 According to the present invention, it is possible to provide a collagen synthesis promoter containing at least one selected from the group consisting of ascorbic acid, ascorbic acid derivatives and salts thereof, and low-molecular-weight betaine as active ingredients. Further, by using both ascorbic acids and low molecular weight betaine, the amount of collagen synthesis in the cells can be remarkably increased. Furthermore, the composition for promoting collagen synthesis containing ascorbic acids and low-molecular-weight betaine prevents collagen decrease, an anti-wrinkle composition, an anti-tarmi composition, a composition for preventing or treating joint disorders, inflammatory It is useful as a composition for preventing or treating diseases.
本発明のアスコルビン酸、アスコルビン酸誘導体及びそれらの塩は、医薬品、医薬部外品または化粧品分野において用いられるものであれば特に限定されない。アスコルビン酸誘導体としては、具体的には、L−アスコルビン酸モノリン酸エステル、L−アスコルビン酸ジリン酸エステル及びL−アスコルビン酸トリリン酸エステル等のL−アスコルビン酸のリン酸エステル誘導体;パルミチン酸アスコルビル、ステアリン酸アスコルビル、ジパルミチン酸アスコルビル等の脂溶性アスコルビン酸誘導体;アスコルビン酸グルコシド等の糖誘導体;L−アスコルビン酸−2−硫酸エステル、L−アスコルビン酸−2−スルホン酸エステル等が例示できる。 The ascorbic acid, ascorbic acid derivative and salts thereof of the present invention are not particularly limited as long as they are used in the field of pharmaceuticals, quasi drugs or cosmetics. Specific examples of the ascorbic acid derivatives include L-ascorbic acid phosphates such as L-ascorbic acid monophosphate, L-ascorbic acid diphosphate and L-ascorbyl triphosphate; ascorbyl palmitate, Examples include fat-soluble ascorbic acid derivatives such as ascorbyl stearate and ascorbyl dipalmitate; sugar derivatives such as ascorbic acid glucoside; L-ascorbic acid-2-sulfate, L-ascorbic acid-2-sulfonate, and the like.
本発明において、上記のアスコルビン酸、アスコルビン酸誘導体及びそれらの塩は、1種単独で使用しても、また2種以上を任意に組み合わせて使用することもできる。本発明の上記のアスコルビン酸、アスコルビン酸誘導体及びそれらの塩のうち好ましくは、L−アスコルビン酸,L−アスコルビン酸のリン酸エステル誘導体,パルミチン酸アスコルビル、アスコルビン酸グルコシド、L−アスコルビン酸−2−硫酸エステル、アスコルビン酸−2−グルコシド及びそれらの塩であり、皮膚や粘膜に対する安全性の高さと作用効果の高さから、特に好ましくは、L−アスコルビン酸,L−アスコルビン酸モノリン酸エステルまたはそれらの塩、パルミチン酸アスコルビル、アスコルビン酸−2−グルコシドである。なお、本発明には、アスコルビン酸類のd体、l体、dl体をいずれも用いることができる。 In the present invention, the above ascorbic acid, ascorbic acid derivatives and salts thereof may be used singly or in any combination of two or more. Among the above ascorbic acid, ascorbic acid derivatives and salts thereof of the present invention, L-ascorbic acid, phosphate derivatives of L-ascorbic acid, ascorbyl palmitate, ascorbic acid glucoside, L-ascorbic acid-2- Sulfuric acid ester, ascorbic acid-2-glucoside and salts thereof, and particularly preferably L-ascorbic acid, L-ascorbic acid monophosphate or the like because of their high safety and action effect on the skin and mucous membranes. Salt, ascorbyl palmitate, ascorbyl 2-glucoside. In the present invention, any of d-form, l-form, and dl-form of ascorbic acids can be used.
本発明で用いられるアスコルビン酸及びアスコルビン酸誘導体の塩としては、ナトリウムやカリウム等のアルカリ金属塩、マグネシウム,カルシウム及びバリウム等のアルカリ土類金属塩、並びにアルミニウム等の多価金属塩などの各種の金属塩:アンモニウムやトリシクロヘキシルアンモニウム等のアンモニウム塩、モノエタノールアミン,ジエタノールアミン,トリエタノールアミン,モノイソプロパノールアミン,ジイソプロパノールアミン,及びトリイソプロパノールアミン等の各種のアルカノールアミン塩を挙げることができる。 Examples of salts of ascorbic acid and ascorbic acid derivatives used in the present invention include various alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium, calcium and barium, and polyvalent metal salts such as aluminum. Metal salts: Examples include ammonium salts such as ammonium and tricyclohexylammonium, and various alkanolamine salts such as monoethanolamine, diethanolamine, triethanolamine, monoisopropanolamine, diisopropanolamine, and triisopropanolamine.
本発明のコラーゲン合成促進用組成物に配合するアスコルビン酸類の配合量は、特に制限されないが、本発明の効果を得るため、組成物全体に対して通常0.00001重量%以上、好ましくは0.001重量%以上、より好ましくは、0.01重量%以上、さらに好ましくは0.1重量%以上、特に好ましくは1重量%以上であり、配合上限は安定性の観点から好ましくは35重量%以下、より好ましくは25重量%以下、さらに好ましくは20重量%以下、特に好ましくは15重量%以下である。 The amount of ascorbic acid to be blended in the composition for promoting collagen synthesis of the present invention is not particularly limited, but in order to obtain the effects of the present invention, it is usually 0.00001% by weight or more, preferably 0.8%. 001% by weight or more, more preferably 0.01% by weight or more, further preferably 0.1% by weight or more, particularly preferably 1% by weight or more, and the upper limit of blending is preferably 35% by weight or less from the viewpoint of stability. More preferably, it is 25% by weight or less, further preferably 20% by weight or less, and particularly preferably 15% by weight or less.
本発明の低分子ベタインとは、分子量200以下であって、分子内で両性イオンを形成する化合物をいう。中でも好ましくは、下記式(1) The low molecular weight betaine of the present invention refers to a compound having a molecular weight of 200 or less and forming zwitterions in the molecule. Among them, the following formula (1) is preferable.
R1〜R3としては、炭素数1〜6の直鎖又は分岐鎖のアルキル基を広く用いることができる。すなわち、メチル基、エチル基、プロピル基、イソプロピル基、ブチル基、イソブチル基、sec−ブチル基、tert−ブチル基、ペンチル基、イソペンチル基、ネオペンチル基、tert−ペンチル基、ヘキシル基、イソヘキシル基、3−メチルペンチル基、2,2−ジメチルブチル基又は2,3−ジメチルブチル基等がそれぞれ例示される。なおR1〜R3は同一であっても異なっていてもよい。
具体的には、n=1のトリメチルグリシン、トリエチルグリシン、トリプロピルグリシン、トリイソプロピルグリシン、n=2のトリメチル−β−アラニン、n=3のトリメチル−γ−アミノ酪酸等が挙げられ、好ましくはトリメチルグリシンである。
また、これらの低分子ベタインは置換されていてもよく、具体的には、n=1のN,N,N−トリメチルアラニン、N,N,N−トリエチルアラニン、N,N,N−トリイソプロピルアラニン、N,N,N−トリメチルメチルアラニン、カルニチン、アセチルカルニチン等が挙げられ、好ましくはカルニチンである。
As R 1 to R 3 , a linear or branched alkyl group having 1 to 6 carbon atoms can be widely used. That is, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group, pentyl group, isopentyl group, neopentyl group, tert-pentyl group, hexyl group, isohexyl group, Examples thereof include a 3-methylpentyl group, a 2,2-dimethylbutyl group, and a 2,3-dimethylbutyl group. R 1 to R 3 may be the same or different.
Specific examples include trimethylglycine with n = 1, triethylglycine, tripropylglycine, triisopropylglycine, n = 2 trimethyl-β-alanine, n = 3 trimethyl-γ-aminobutyric acid, etc. Trimethylglycine.
These low molecular betaines may be substituted. Specifically, N = 1, N, N, N-trimethylalanine, N, N, N-triethylalanine, N, N, N-triisopropyl Examples include alanine, N, N, N-trimethylmethylalanine, carnitine, acetylcarnitine, and the like, preferably carnitine.
本発明のコラーゲン合成促進用組成物において低分子ベタインの配合量は、好ましくは0.000001〜10重量%であり、より好ましくは0.0001〜10重量%、さらに好ましくは0.01〜8重量%、特に好ましくは0.1〜7重量%の範囲である。0.000001重量%未満では効果が発揮できない場合があり、また10重量%を超えると使用感が悪くなる場合がある。 In the composition for promoting collagen synthesis of the present invention, the amount of low molecular betaine is preferably 0.000001 to 10% by weight, more preferably 0.0001 to 10% by weight, still more preferably 0.01 to 8% by weight, particularly preferably 0.1. It is in the range of ~ 7% by weight. If it is less than 0.000001% by weight, the effect may not be exhibited, and if it exceeds 10% by weight, the feeling of use may be deteriorated.
また、本発明においてアスコルビン酸類と低分子ベタインとを併用する割合は重量比で、通常アスコルビン酸類1重量部に対して低分子ベタインが、0.001〜100重量部の範囲、好ましくは0.01〜30重量部、より好ましくは0.1〜30重量部、さらに好ましくは0.1〜20重量部の範囲である。 In the present invention, the ratio of the combination of ascorbic acid and low molecular betaine is a weight ratio, and the low molecular betaine is usually in the range of 0.001 to 100 parts by weight, preferably 0.01 to 1 part by weight of ascorbic acid. It is -30 weight part, More preferably, it is 0.1-30 weight part, More preferably, it is the range of 0.1-20 weight part.
本発明のコラーゲン合成促進用組成物には、前述するアスコルビン酸類及び低分子ベタインに加えて、アスコルビン酸類又は低分子ベタイン各種の作用を増強または補足する目的で、あるいはコラーゲン合成促進用組成物に他の有用な作用を付加するため美白成分、抗炎症成分、抗菌成分、細胞賦活化成分、収斂成分、抗酸化成分、ニキビ改善成分、コラーゲン等の生体成分合成促進成分、血行促進成分、保湿成分、老化防止成分等の各種成分を1種または2種以上組み合わせて配合することができる。好ましくは美白成分、抗炎症成分、抗菌成分、細胞賦活化成分、収斂成分、抗酸化成分、老化防止成分または保湿成分の1種または2種以上の成分である。これらの各成分としては、医薬品、医薬部外品、または化粧品分野において従来より使用され、また将来使用されるものであれば特に制限されず、任意のものを適宜選択し使用することができる。 The composition for promoting collagen synthesis of the present invention includes, in addition to the aforementioned ascorbic acids and low molecular betaine, for the purpose of enhancing or supplementing various actions of ascorbic acids or low molecular betaines, or in addition to the composition for promoting collagen synthesis. Whitening ingredients, anti-inflammatory ingredients, antibacterial ingredients, cell activating ingredients, astringent ingredients, antioxidant ingredients, acne improving ingredients, collagen and other biocomponent synthesis promoting ingredients, blood circulation promoting ingredients, moisturizing ingredients, Various components such as anti-aging components can be blended alone or in combination of two or more. Preferred are one or more of whitening components, anti-inflammatory components, antibacterial components, cell activation components, astringent components, antioxidant components, anti-aging components or moisturizing components. These components are not particularly limited as long as they are conventionally used in the pharmaceutical, quasi-drug or cosmetic field, and will be used in the future, and arbitrary components can be appropriately selected and used.
例えば、美白成分としては、プラセンタ;アルブチン;コウジ酸;エラグ酸;フィチン酸;ルシノール;カモミラET;ビタミンA又はその誘導体、ビタミンE又はその誘導体、パントテン酸又はその誘導体等のビタミン類等が挙げられる。このうち、好ましいものとしては、パントテン酸又はその誘導体、エラグ酸、フィチン酸、ビタミンA又はその誘導体、ビタミンE又はその誘導体を挙げることができる。これらの美白成分は1種または2種以上を用いてもよい。 Examples of whitening components include placenta; arbutin; kojic acid; ellagic acid; phytic acid; lucinol; chamomile ET; vitamin A or a derivative thereof, vitamin E or a derivative thereof, vitamins such as pantothenic acid or a derivative thereof, and the like. . Of these, preferred are pantothenic acid or its derivatives, ellagic acid, phytic acid, vitamin A or its derivatives, vitamin E or its derivatives. These whitening components may be used alone or in combination of two or more.
美白作用を有する植物成分を美白成分として用いてもよく、かかる植物成分としては、イリス(アイリス)、アーモンド、アロエ、イチョウ、ウーロン茶、エイジツ、オウゴン、オウレン、オトギリソウ、オドリコソウ、海藻、カッコン、クチナシ、クジン、クロレラ、ゴバイシ、コムギ、コメ、コメハイガ、オリザノール、コメヌカ、サイシン、サンショウ、シソ、シャクヤク、センキュウ、ソウハクヒ、ダイズ、納豆、茶、トウキ、トウキンセンカ、ニンニク、ハマメリス、ベニバナ、ボタンピ、ヨクイニン、トウキ、アメジスト、アセンヤク、アセビワラビ、イヌマキ、エノキ、カキ(Diospyros kaki)、キササゲ、クロマメ、ゲンチアナ、ゲンジン、サルサ、サヤインゲン、ショクマ、ジュウロウ、セージ、ゼンコ、ダイコン、ツツジ、ツクシハギ、トシン、ニガキ、パセリ、ヒイラギ、ホップ、マルバハギ、チョウジ、カンゾウ等の植物に由来する成分が挙げられる。好ましくは、イリス(アイリス)、アロエ、イチョウ、ウーロン茶、エイジツ、オウゴン、オウレン、オトギリソウ、オドリコソウ、海藻、カッコン、クチナシ、クジン、ゴバイシ、コムギ、コメ、コメヌカ、サイシン、サンショウ、シソ、シャクヤク、センキュウ、ソウハクヒ、茶、トウキ、トウキンセンカ、ハマメリス、ベニバナ、ボタンピ、ヨクイニン、アメジスト、アセンヤク、エノキ、カキ(Diospyros kaki)、キササゲ、クロマメ、ゲンチアナ、サルサ、サヤインゲン、ジュウロウ、セージ、ゼンコ、ダイコン、ツツジ、ツクシハギ、トシン、ニガキ、パセリ、ヒイラギ、ホップ、チョウジ、カンゾウ及びトウキの植物由来成分であり、より好ましくは、イリス(アイリス)、アロエ、イチョウ、エイジツ、オウゴン、オウレン、オトギリソウ、クチナシ、クジン、コメ、コメヌカ、サイシン、シャクヤク、センキュウ、ソウハクヒ、茶、トウキ、トウキンセンカ、ハマメリス、ベニバナ、ボタンピ、アメジスト、アセンヤク、エノキ、カキ(Diospyros kaki)、セージ、ダイコン、ツツジ、パセリ、ホップ、カンゾウ及びヨクイニンの植物由来成分である。
これらの植物成分を本発明のコラーゲン合成促進用組成物に用いる場合、植物成分の形態は特に制限されないが、通常は植物エキス(植物抽出物)や精油などの態様で使用することができる。なお、上記植物成分中に記載の( )内は、その植物の種類、別名または生薬名である。
A plant component having a whitening effect may be used as a whitening component, such as Iris (iris), almond, aloe, ginkgo, oolong tea, ages, ogon, lauren, hypericum, licorice, seaweed, cuckoo, gardenia, Kujin, chlorella, gobaishi, wheat, rice, rice haiga, oryzanol, rice bran, saishin, salamander, perilla, peony, senkyu, sakuhaku, soybeans, natto, tea, toki, pearl millet, garlic, hamamelis, safflower, buttonpi, yokuinin, Japanese apricot, amethyst, asenyaku, aseibarabi, hinoki oyster, enoki, oyster (Diospyros kaki), cowpea, black bean, gentian, genzin, salsa, sweet bean, shokuma, jujuu, sage, senko, radish, azalea, tsuku Ingredients derived from plants such as shigigi, toshin, nigaki, parsley, holly, hops, malbahagi, clove and licorice can be mentioned. Preferably, Iris (Iris), Aloe, Ginkgo, Oolong tea, Ages, Ogon, Oulen, Hypericum, Olysam, Seaweed, Cuckoo, Gardenia, Kujin, Gobaishi, Wheat, Rice, Rice bran, Saishin, Salamander, Perilla, Peonies, Senkyu , Sowakuhi, Tea, Toki, Toki-Senka, Hamelis, Safflower, Buttonpi, Yokuinin, Amethyst, Acacia, Enoki, Oyster, Diospyros kaki, Catalpa, Black bean, Gentian, Salsa, Soyagen, Juju, Sage, Zenko, Daikon, Tsuji It is a plant-derived component of Tsukuhashigi, Toshin, Nigaki, Parsley, Holly, Hops, Clove, Licorice and Toki, and more preferably Iris (Iris), Aloe, Ginkgo, Ages, Ogon, Oulen, Otogi Riso, gardenia, cucumber, rice, rice bran, saishin, peony, senkyu, sakuhakuhi, tea, touki, eucalyptus, hamamelis, safflower, buttonpi, amethyst, asenyaku, enoki, oyster (Diospyros kaki), sage, radish, azalea, azalea It is a plant-derived component of hops, licorice and yokuinin.
When these plant components are used in the composition for promoting collagen synthesis of the present invention, the form of the plant components is not particularly limited, but can be generally used in the form of a plant extract (plant extract), an essential oil, or the like. In addition, the inside of () described in the said plant component is the kind of plant, an alias, or a crude drug name.
上記美白成分を用いる場合、コラーゲン合成促進用組成物に配合する割合は、好ましくは0.0003〜10重量%であり、より好ましくは0.01〜5重量%である。また、美白成分はコラーゲン合成促進用組成物に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。
美白成分として美白作用のある植物成分を用いる場合は、目的に応じて1種もしくは2種以上を任意に組み合わせて使用することができる。上記植物成分を美白成分として用いる場合、コラーゲン合成促進用組成物への配合割合は、エキスや精油などの抽出物換算で、通常0.00001〜20重量%、好ましくは0.0001〜15重量%、より好ましくは0.001〜10重量%である。また、植物成分はアスコルビン酸類100重量部に対して0.0001〜100重量部、好ましくは0.001〜50重量部の割合になるように配合することが望ましい。
When using the said whitening component, the ratio mix | blended with the composition for collagen synthesis promotion becomes like this. Preferably it is 0.0003 to 10 weight%, More preferably, it is 0.01 to 5 weight%. Further, the whitening component is 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, more preferably 0.01 to 100 parts by weight with respect to 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to mix | blend so that it may become a ratio.
When a plant component having a whitening effect is used as the whitening component, one or two or more kinds can be used in any combination depending on the purpose. When the plant component is used as a whitening component, the blending ratio in the composition for promoting collagen synthesis is usually 0.00001 to 20% by weight, preferably 0.0001 to 15% by weight in terms of an extract such as extract or essential oil. More preferably, it is 0.001 to 10% by weight. Moreover, it is desirable that the plant component is blended so as to have a ratio of 0.0001 to 100 parts by weight, preferably 0.001 to 50 parts by weight with respect to 100 parts by weight of ascorbic acids.
抗炎症成分としては、アラントイン、カラミン、グリチルリチン酸又はその誘導体、グリチルレチン酸又はその誘導体、酸化亜鉛、グアイアズレン、酢酸トコフェロール、塩酸ピリドキシン、メントール、カンフル、テレピン油、インドメタシン、サリチル酸又はその誘導体等が挙げられる。好ましくはアラントイン、グリチルリチン酸又はその誘導体、グリチルレチン酸又はその誘導体、グアイアズレン、メントールである。 Anti-inflammatory components include allantoin, calamine, glycyrrhizic acid or derivatives thereof, glycyrrhetinic acid or derivatives thereof, zinc oxide, guaiazulene, tocopherol acetate, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid or derivatives thereof. . Preferred are allantoin, glycyrrhizic acid or a derivative thereof, glycyrrhetinic acid or a derivative thereof, guaiazulene, or menthol.
上記抗炎症成分を用いる場合、コラーゲン合成促進用組成物に配合する割合は、好ましくは0.0003〜10重量%であり、より好ましくは0.01〜5重量%である。また、抗炎症成分はコラーゲン合成促進用組成物中に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。 When using the said anti-inflammatory component, the ratio mix | blended with the composition for collagen synthesis promotion becomes like this. Preferably it is 0.0003 to 10 weight%, More preferably, it is 0.01 to 5 weight%. Further, the anti-inflammatory component is 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, more preferably 0.01 to 100 parts by weight based on 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to blend so as to have a proportion by weight.
抗菌成分としては、クロルヘキシジン、サリチル酸、塩化ベンザルコニウム、アクリノール、エタノール、塩化ベンゼトニウム、クレゾール、グルコン酸及びその誘導体、ポピドンヨード、ヨウ化カリウム、ヨウ素、イソプロピルメチルフェノール、トリクロカルバン、トリクロサン、感光素101号、感光素201号、パラベン、フェノキシエタノール、1,2-ペンタンジオール、塩酸アルキルジアミノグリシン等が挙げられる。好ましくは、塩化ベンザルコニウム、塩化ベンゼトニウム、グルコン酸及びその誘導体、イソプロピルメチルフェノール、トリクロカルバン、トリクロサン、感光素101号、感光素201号、パラベン、フェノキシエタノール、1,2-ペンタンジオール、塩酸アルキルジアミノグリシン等が挙げられる。さらに好ましくは、塩化ベンザルコニウム、グルコン酸及びその誘導体、塩化ベンゼトニウム、イソプロピルメチルフェノールである。 Antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101 Photosensitive element 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride and the like. Preferably, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiamino hydrochloride Examples include glycine. More preferred are benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol.
上記抗菌成分を用いる場合、コラーゲン合成促進用組成物に配合する割合は、好ましくは0.0003〜10重量%であり、より好ましくは0.01〜5重量%である。また、抗菌成分はコラーゲン合成促進用組成物中に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。 When the antibacterial component is used, the proportion of the composition for promoting collagen synthesis is preferably 0.0003 to 10% by weight, more preferably 0.01 to 5% by weight. Further, the antibacterial component is 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, more preferably 0.01 to 100 parts by weight with respect to 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to blend so as to have a ratio of parts.
細胞賦活化成分としては、γ-アミノ酪酸、ε-アミノカプロン酸などのアミノ酸類:レチノール、チアミン、リボフラビン、塩酸ピリドキシン、パントテン酸類などのビタミン類:グリコール酸、乳酸などのα-ヒドロキシ酸類:タンニン、フラボノイド、サポニン、アラントイン、感光素301号などが挙げられる。好ましくは、γ-アミノ酪酸、ε-アミノカプロン酸などのアミノ酸類:レチノール、チアミン、リボフラビン、塩酸ピリドキシン、パントテン酸類などのビタミン類である。 Cell activation components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid: vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride and pantothenic acids: α-hydroxy acids such as glycolic acid and lactic acid: tannin, Examples include flavonoids, saponins, allantoin, and photosensitizer 301. Preferred are amino acids such as γ-aminobutyric acid and ε-aminocaproic acid: vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride and pantothenic acids.
上記細胞賦活化成分を用いる場合、コラーゲン合成促進用組成物に配合する割合は、好ましくは0.0003〜10重量%であり、より好ましくは0.01〜5重量%である。また、細胞賦活成分はコラーゲン合成促進用組成物中に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。 When the cell activation component is used, the proportion to be added to the composition for promoting collagen synthesis is preferably 0.0003 to 10% by weight, more preferably 0.01 to 5% by weight. Further, the cell activation component is 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, more preferably 0.01 to 100 parts by weight based on 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to blend so as to have a proportion by weight.
収斂成分としては、ミョウバン、クロロヒドロキシアルミニウム、塩化アルミニウム、アラントインアルミニウム塩、硫酸亜鉛、硫酸アルミニウムカリウム等の金属塩;タンニン酸、クエン酸、乳酸、コハク酸などの有機酸を挙げることができる。好ましくは、ミョウバン、クロロヒドロキシアルミニウム、塩化アルミニウム、アラントインアルミニウム塩、硫酸アルミニウムカリウム、タンニン酸である。 Examples of the astringent component include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and aluminum potassium sulfate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferred.
収斂成分を用いる場合、そのコラーゲン合成促進用組成物に配合する割合は、通常0.0003〜10重量%、好ましくは0.01〜5重量%、より好ましくは0.01〜5重量%である。また、収斂成分はコラーゲン合成促進用組成物中に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。 When using an astringent component, the proportion to be added to the composition for promoting collagen synthesis is usually 0.0003 to 10% by weight, preferably 0.01 to 5% by weight, more preferably 0.01 to 5% by weight. . The astringent component is 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, more preferably 0.01 to 100 parts by weight, based on 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to blend so as to have a ratio of parts.
抗酸化成分としては、トコフェロール及びその誘導体、ブチルヒドロキシアニソール、ジブチルヒドロキシトルエン、亜硫酸水素ナトリウム、エリソルビン酸及びその塩、フラボノイド、グルタチオン、グルタチオンペルオキシダーゼ、グルタチオン-S-トランスフェラーゼ、カタラーゼ、スーパーオキサイドジスムターゼ、チオレドキシン、タウリン、チオタウリン、ヒポタウリンなどが挙げられる。好ましくは、トコフェロール及びその誘導体、チオタウリン、ヒポタウリン、チオレドキシン、フラボノイドである。 Antioxidant components include tocopherol and its derivatives, butylhydroxyanisole, dibutylhydroxytoluene, sodium bisulfite, erythorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, Examples include taurine, thiotaurine, and hypotaurine. Tocopherol and its derivatives, thiotaurine, hypotaurine, thioredoxin, and flavonoid are preferable.
抗酸化成分を用いる場合、コラーゲン合成促進用組成物に配合する割合は、通常0.00001〜10重量%、好ましくは0.0001〜5重量%、より好ましくは0.001〜5重量%である。またコラーゲン合成促進用組成物中に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。 In the case of using an antioxidant component, the proportion to be added to the composition for promoting collagen synthesis is usually 0.0001 to 10% by weight, preferably 0.0001 to 5% by weight, more preferably 0.001 to 5% by weight. . The ratio of 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, and more preferably 0.01 to 100 parts by weight with respect to 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to blend so that.
老化防止成分としては、レチノイド(レチノール、レチノイン酸、レチナール等)、パンガミン酸、カイネチン、ウルソール酸、ウコンエキス、スフィンゴシン誘導体、ケイ素、ケイ酸、N−メチル−L−セリン、メバロノラクトン等が挙げられる。好ましくは、レチノイド(レチノール、レチノイン酸、レチナール等)、カイネチンである。 Antiaging components include retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, and the like. Preferred are retinoid (retinol, retinoic acid, retinal, etc.) and kinetin.
上記老化防止成分を用いる場合、コラーゲン合成促進用組成物に配合する割合は、好ましくは0.0003〜10重量%であり、より好ましくは0.01〜5重量%である。また、老化防止成分はコラーゲン合成促進用組成物中に含まれるアスコルビン酸類100重量部に対して0.001 〜1000重量部、好ましくは0.005〜500重量部、より好ましくは0.01〜100重量部の割合になるように配合することが望ましい。 When using the said anti-aging component, the ratio mix | blended with the composition for collagen synthesis promotion becomes like this. Preferably it is 0.0003 to 10 weight%, More preferably, it is 0.01 to 5 weight%. The anti-aging component is 0.001 to 1000 parts by weight, preferably 0.005 to 500 parts by weight, more preferably 0.01 to 100 parts by weight based on 100 parts by weight of ascorbic acids contained in the composition for promoting collagen synthesis. It is desirable to blend so as to have a proportion by weight.
保湿成分としては、アラニン、セリン、ロイシン、イソロイシン、スレオニン、グリシン、プロリン、ヒドロキシプロリン、グルコサミン、テアニンなどのアミノ酸及びその誘導体;コラーゲン、コラーゲンペプチド、ゼラチン等のペプチド;グリセリン、1,3-ブチレングリコール、プロピレングリコール、ポリエチレングリコールなどの多価アルコール;ソルビトールなどの糖アルコール;レシチン、水素添加レシチン等のリン脂質;ヒアルロン酸プロピレングリコール、ヘパリン、コンドロイチン等のムコ多糖;乳酸、ピロリドンカルボン酸ナトリウム、尿素などのNMF由来成分などがあげられる。好ましいものは、アラニン、セリン、グリシン、プロリン、ヒドロキシプロリン、グルコサミン、テアニン、コラーゲン、コラーゲンペプチド、グリセリン、1,3-ブチレングリコール、水素添加レシチン、ヒアルロン酸プロピレングリコール、ヘパリン、コンドロイチン、乳酸、ピロリドンカルボン酸ナトリウである。 As moisturizing ingredients, amino acids such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, theanine and derivatives thereof; peptides such as collagen, collagen peptide, gelatin; glycerin, 1,3-butylene glycol Polyhydric alcohols such as propylene glycol and polyethylene glycol; Sugar alcohols such as sorbitol; Phospholipids such as lecithin and hydrogenated lecithin; Mucopolysaccharides such as propylene glycol hyaluronate, heparin and chondroitin; Lactic acid, sodium pyrrolidonecarboxylate, urea, etc. NMF-derived components and the like. Preferred are alanine, serine, glycine, proline, hydroxyproline, glucosamine, theanine, collagen, collagen peptide, glycerin, 1,3-butylene glycol, hydrogenated lecithin, propylene glycol hyaluronate, heparin, chondroitin, lactic acid, pyrrolidone carboxylic acid It is acid sodium.
保湿成分を用いる場合、コラーゲン合成促進用組成物に配合する割合としては、通常0.1〜10重量%、好ましくは0.5〜5重量%、より好ましくは0.5〜5重量%を挙げることができる。 When using a moisturizing component, the proportion to be added to the composition for promoting collagen synthesis is usually 0.1 to 10% by weight, preferably 0.5 to 5% by weight, more preferably 0.5 to 5% by weight. be able to.
本発明のコラーゲン合成促進用組成物は、上記各成分に加えて組成物の用途あるいは剤形に応じて、食品、医薬部外品、医薬品に通常使用される成分を適宜配合しても良い。配合できる成分としては、特に制限されないが、例えば、アミノ酸類、アルコール類、多価アルコール類、糖類、ガム質、多糖類などの高分子化合物、界面活性剤、可溶化成分、油脂類、経皮吸収促進成分、防腐・抗菌・殺菌剤、pH調整剤、キレート剤、抗酸化剤、酵素成分、結合剤、崩壊剤、滑沢剤、流動化剤、清涼化剤の他、ミネラル類、細胞賦活剤、滋養強壮剤、賦形剤、増粘剤、安定化剤、保存剤、等張化剤、分散剤、吸着剤、崩壊補助剤、湿潤剤または湿潤調節剤、防湿剤、着色料、着香剤または香料、芳香剤、還元剤、可溶化剤、溶解補助剤、発泡剤、粘稠剤または粘稠化剤、溶剤、基剤、乳化剤、可塑剤、緩衝剤、光沢化剤などをあげることができる。特に界面活性剤、可溶化成分または油脂類を配合することによって、水性溶媒中におけるアスコルビン酸類の安定性、有効性、使用感をより向上させることができる。また、本発明の組成物が外用組成物である場合には、界面活性剤、可溶化成分、油脂類または経皮吸収促進成分を配合するのが好ましい。 In the composition for promoting collagen synthesis of the present invention, in addition to the above-described components, components usually used in foods, quasi drugs and pharmaceuticals may be appropriately blended depending on the use or dosage form of the composition. The component that can be blended is not particularly limited, but for example, amino acids, alcohols, polyhydric alcohols, saccharides, gums, polysaccharides and other high molecular compounds, surfactants, solubilizing components, fats and oils, transdermal Absorption-promoting ingredients, antiseptic / antibacterial / bactericidal agents, pH adjusters, chelating agents, antioxidants, enzyme components, binders, disintegrating agents, lubricants, fluidizing agents, cooling agents, minerals, cell activation Agents, nourishing tonics, excipients, thickeners, stabilizers, preservatives, isotonic agents, dispersants, adsorbents, disintegration aids, wetting agents or wetting regulators, dampening agents, coloring agents, wearing Perfume or fragrance, fragrance, reducing agent, solubilizer, solubilizer, foaming agent, thickener or thickener, solvent, base, emulsifier, plasticizer, buffer, brightener, etc. be able to. In particular, by adding a surfactant, a solubilizing component, or fats and oils, the stability, effectiveness, and feeling of use of ascorbic acids in an aqueous solvent can be further improved. Moreover, when the composition of this invention is a composition for external use, it is preferable to mix | blend surfactant, a solubilizing component, fats and oils, or a percutaneous absorption promoting component.
ここで用いられる界面活性剤としては、ポリオキシエチレン(以下、POEという)−オクチルドデシルアルコールやPOE−2−デシルテトラデシルアルコール等のPOE−分岐アルキルエーテル;POE −オレイルアルコールエーテルやPOE−セチルアルコールエーテル等のPOE−アルキルエーテル;ソルビタンモノオレエート、ソルビタンモノイソステアレート及びソルビタンモノラウレート等のソルビタンエステル;POE−ソルビタンモノオレエート、POE−ソルビタンモノイソステアレート、及びPOE−ソルビタンモノラウレート等のPOE−ソルビタンエステル;グリセリンモノオレエート、グリセリンモノステアレート、及びグリセリンモノミリステート等のグリセリン脂肪酸エステル;POE−グリセリンモノオレエート、POE−グリセリンモノステアレート、及びPOE−グリセリンモノミリステート等のPOE−グリセリン脂肪酸エステル;POE−ジヒドロコレステロールエステル、POE−硬化ヒマシ油、及びPOE−硬化ヒマシ油イソステアレート等のPOE−硬化ヒマシ油脂肪酸エステル;POE−オクチルフェニルエーテル等のPOE−アルキルアリールエーテル;モノイソステアリルグリセリルエーテルやモノミリスチルグリセリルエーテル等のグリセリンアルキルエーテル;POE−モノステアリルグリセリルエーテル、POE−モノミリスチルグリセリルエーテル等のPOE−グリセリンアルキルエーテル;ジグリセリルモノステアレート、デカグリセリルデカステアレート、デカグリセリルデカイソステアレート、及びジグリセリルジイソステアレート等のポリグリセリン脂肪酸エステル、等の各種非イオン界面活性剤::あるいはレシチン、水素添加レシチン、サポニン、サーファクチンナトリウム、コレステロール、胆汁酸などの天然由来の界面活性剤等を例示することができる。これらの界面活性剤は、1種単独で使用してもまた2種以上を任意に組み合わせて使用してもよい。 Examples of the surfactant used herein include POE-branched alkyl ethers such as polyoxyethylene (hereinafter referred to as POE) -octyldodecyl alcohol and POE-2-decyltetradecyl alcohol; POE-oleyl alcohol ether and POE-cetyl alcohol. POE-alkyl ethers such as ethers; sorbitan esters such as sorbitan monooleate, sorbitan monoisostearate and sorbitan monolaurate; POE-sorbitan monooleate, POE-sorbitan monoisostearate, and POE-sorbitan monolaurate POE-sorbitan esters such as glycerol; glycerol fatty acid esters such as glycerol monooleate, glycerol monostearate, and glycerol monomyristate; POE-glycerol monoo POE-cured fatty acid esters such as reate, POE-glycerin monostearate, and POE-glycerin monomyristate; POE-cured such as POE-dihydrocholesterol ester, POE-cured castor oil, and POE-cured castor oil isostearate Castor oil fatty acid ester; POE-alkyl aryl ether such as POE-octylphenyl ether; Glycerin alkyl ether such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether; POE such as POE-monostearyl glyceryl ether and POE-monomyristyl glyceryl ether -Glycerin alkyl ethers; diglyceryl monostearate, decaglyceryl decastearate, decaglyceryl decaisostearate, and diglyceride Various nonionic surfactants such as polyglycerin fatty acid esters such as rildiisostearate: or natural surfactants such as lecithin, hydrogenated lecithin, saponin, surfactin sodium, cholesterol, bile acids, etc. can do. These surfactants may be used alone or in any combination of two or more.
界面活性剤を使用する場合、コラーゲン合成促進用組成物への配合割合としては、副作用がなく皮膚や粘膜に影響を与えず且つ本発明の効果を妨げないことを限度として特に制限されず、コラーゲン合成促進用組成物中に0.01〜30重量%の割合で含まれるような範囲で適宜選択して使用することができる。コラーゲン合成促進用組成物中の有効成分の安定性や皮膚使用感等の観点からは、好ましくは0.1〜20重量%、より好ましくは0.5〜10重量%の範囲を挙げることができる。 When using a surfactant, the blending ratio in the composition for promoting collagen synthesis is not particularly limited as long as it has no side effects, does not affect the skin and mucous membranes, and does not interfere with the effects of the present invention. It can be appropriately selected and used within a range such that it is contained in the composition for promoting synthesis at a ratio of 0.01 to 30% by weight. From the viewpoint of stability of active ingredients in the composition for promoting collagen synthesis, skin use feeling, and the like, it is preferably 0.1 to 20% by weight, more preferably 0.5 to 10% by weight. .
可溶化成分としては、医薬品、医薬部外品または化粧品分野において用いられるものであれば特に限定されない。例えば、エタノール等の低級アルコール、グリセリン,エチレングリコール等の多価アルコール、水素添加大豆リン脂質、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンラノリンアルコール、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンステロール、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル等を挙げることができる。好ましくは、エタノール、グリセリン、エチレングリコール、ジエチレングリコール、ジプロピレングリコール、水素添加大豆リン脂質、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンラノリンアルコール、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンアルキルエーテルであり、より好ましくは、エタノール、グリセリン、エチレングリコール、ジエチレングリコール、ジプロピレングリコール、水素添加大豆リン脂質である。これらの可溶化成分は、1種単独で使用しても、または2種以上を任意に組み合わせて用いてもよい。 The solubilizing component is not particularly limited as long as it is used in the field of pharmaceuticals, quasi drugs or cosmetics. For example, lower alcohols such as ethanol, polyhydric alcohols such as glycerin and ethylene glycol, hydrogenated soybean phospholipid, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene lanolin alcohol, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, Examples thereof include polyoxyethylene sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether and the like. Preferably, ethanol, glycerin, ethylene glycol, diethylene glycol, dipropylene glycol, hydrogenated soybean phospholipid, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene lanolin alcohol, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxy Ethylene alkyl ether, more preferably ethanol, glycerin, ethylene glycol, diethylene glycol, dipropylene glycol, and hydrogenated soybean phospholipid. These solubilizing components may be used alone or in any combination of two or more.
これらの可溶化成分を使用する場合、コラーゲン合成促進用組成物への配合割合としては、副作用がなく皮膚や粘膜に影響を与えず且つ本発明の効果を妨げないことを限度として特に制限されず、コラーゲン合成促進用組成物中に0.01〜70重量%の割合で含まれるような範囲で適宜選択して使用することができるが、コラーゲン合成促進用組成物中の有効成分の安定性や皮膚使用感等の観点からは、好ましくは0.1〜50重量%、より好ましくは0.1〜30重量%の範囲を挙げることができる。 When using these solubilized components, the blending ratio in the composition for promoting collagen synthesis is not particularly limited as long as it has no side effects, does not affect the skin and mucous membranes, and does not interfere with the effects of the present invention. The composition for promoting collagen synthesis can be appropriately selected and used within a range of 0.01 to 70% by weight, but the stability of the active ingredient in the composition for promoting collagen synthesis From the viewpoint of skin feeling, etc., the range is preferably 0.1 to 50% by weight, more preferably 0.1 to 30% by weight.
油脂類としては、医薬品、医薬部外品または化粧品分野において外用剤の成分として用いられるものであれば特に限定されない。例えば、中鎖脂肪酸トリグリセリド等の合成油脂;大豆油、米油、菜種油、綿実油、ゴマ油、サフラワー油、ヒマシ油、オリーブ油、カカオ油、椿油、ヒマワリ油、パーム油、アマ油、シソ油、シア油、サル油、ヤシ油、木ロウ、ホホバ油、グレープシード油、及びアボガド油等の植物油脂;ミンク油、卵黄油、牛脂、乳脂、及び豚脂等の動物油脂;ミツロウ、鯨ロウ、ラノリン、カルナウバロウ、キャンデリラロウ等のロウ類;流動パラフィン、スクワレン、スクワラン、マイクロクリスタリンワックス、セレシンワックス、パラフィンワックス、ワセリン等の炭化水素類;ラウリン酸、ミリスチン酸、ステアリン酸、オレイン酸、イソステアリン酸、ベヘニン酸等の天然及び合成脂肪酸;セタノール、ステアリルアルコール、ヘキシルデカノール、オクチルデカノール、ラウリルアルコール等の天然及び合成高級アルコール;ミリスチン酸イソプロピル、パルミチン酸イソプロピル、ミリスチン酸オクチルドデシル、オレイン酸オクチルドデシル、コレステロールオレート等のエステルやエーテル類;シリコーン油等が挙げられる。これらの油脂類は、1種単独で使用しても、または2種以上を任意に組み合わせて用いてもよい。 The fats and oils are not particularly limited as long as they are used as components of external preparations in the field of pharmaceuticals, quasi drugs and cosmetics. For example, synthetic fats and oils such as medium chain fatty acid triglycerides; soybean oil, rice oil, rapeseed oil, cottonseed oil, sesame oil, safflower oil, castor oil, olive oil, cacao oil, coconut oil, sunflower oil, palm oil, flax oil, perilla oil, shea Vegetable oils such as oil, monkey oil, palm oil, tree wax, jojoba oil, grape seed oil, and avocado oil; animal oils such as mink oil, egg yolk oil, beef tallow, milk fat, and pork fat; beeswax, whale wax, lanolin Waxes such as carnauba wax and candelilla wax; hydrocarbons such as liquid paraffin, squalene, squalane, microcrystalline wax, ceresin wax, paraffin wax, petrolatum; lauric acid, myristic acid, stearic acid, oleic acid, isostearic acid, Natural and synthetic fatty acids such as behenic acid; cetanol, stearyl alcohol, hexylde Nord, octyldecanol, natural and synthetic higher alcohols such as lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, esters and ethers such as cholesterol oleate; silicone oil, and the like. These fats and oils may be used alone or in any combination of two or more.
これらの油脂類を使用する場合、コラーゲン合成促進用組成物への配合割合としては、副作用がなく皮膚や粘膜に影響を与えず且つ本発明の効果を妨げないことを限度として特に制限されず、コラーゲン合成促進用組成物中に0.01〜70重量%の割合で含まれるような範囲で適宜選択して使用することができるが、コラーゲン合成促進用組成物中の有効成分の安定性や皮膚使用感等の観点から、好ましくは0.1〜60重量%、より好ましくは0.1〜50重量%の範囲を挙げることができる。 When these fats and oils are used, the blending ratio in the composition for promoting collagen synthesis is not particularly limited as long as it has no side effects, does not affect the skin and mucous membranes, and does not interfere with the effects of the present invention. Although it can be appropriately selected and used within the range of 0.01 to 70% by weight in the composition for promoting collagen synthesis, the stability of the active ingredient in the composition for promoting collagen synthesis and the skin From the viewpoint of the feeling of use and the like, the range is preferably 0.1 to 60% by weight, more preferably 0.1 to 50% by weight.
本発明のコラーゲン合成促進用組成物は、組成物の用途に応じて、食品、医薬部外品、化粧品に通常使用される剤形をとることができ、通常、固形剤、半固形剤または液剤である。具体的には、錠剤(口腔内側崩壊錠、咀嚼可能錠、発泡錠、トローチ剤、ゼリー状ドロップ剤などを含む)、丸剤、顆粒剤、細粒剤、散剤、硬カプセル剤、軟カプセル剤、ドライシロップ剤、液剤(ドリンク剤、懸濁剤、シロップ剤を含む)、ゲル剤、リポソーム剤、エキス剤、チンキ剤、レモネード剤、軟膏剤、ゼリー剤などの公知の形態をとることができる。また、必要に応じてその他の溶媒や通常使用される基剤等を配合することによって、ペースト状、ムース状、ジェル状、液状、乳液状、クリーム状、シート状(基材担持)、エアゾール状、スプレー状などの各種所望の形態に調製することができる。 The composition for promoting collagen synthesis of the present invention can take a dosage form usually used for foods, quasi-drugs, and cosmetics depending on the use of the composition, and is usually a solid, semi-solid, or liquid. It is. Specifically, tablets (including orally disintegrating tablets, chewable tablets, effervescent tablets, troches, jelly drops, etc.), pills, granules, fine granules, powders, hard capsules, soft capsules , Dry syrups, liquids (including drinks, suspensions, syrups), gels, liposomes, extracts, tinctures, lemonades, ointments, jellys and the like. In addition, pastes, mousses, gels, liquids, emulsions, creams, sheets (substrate support), aerosols can be added by blending other solvents and commonly used bases as necessary. It can be prepared in various desired forms such as spray.
これらの剤形は当業界の通常の方法にて製造することができる。例えば、半固形剤であれば、アスコルビン酸類、低分子ベタイン並びに必要に応じて上記各任意成分を配合混合し、さらに必要に応じてその他の溶媒や通常使用される外用剤の基剤等を配合することによって、ペースト状、ムース状、ジェル状、液状、乳液状、クリーム状、シート状(基材担持)、エアゾール状、スプレー状などの各種所望の形態に調製することができる。 These dosage forms can be prepared by conventional methods in the art. For example, in the case of a semi-solid preparation, ascorbic acids, low molecular betaine and the above optional components are mixed and mixed as necessary, and other solvents and bases for commonly used external preparations are mixed as necessary. By doing so, it can be prepared in various desired forms such as paste, mousse, gel, liquid, emulsion, cream, sheet (supported substrate), aerosol, and spray.
本発明のコラーゲン合成促進用組成物は、通常pH1〜8の液性を備えていればよいが、半固形剤又は液剤にする場合、アスコルビン酸類の安定性、皮膚や粘膜に対する低刺激性、及び皮膚使用感のよさという観点から、好ましくはpH2〜7、より好ましくはpH2〜6の酸性領域であることが望ましい。 The composition for accelerating collagen synthesis of the present invention is usually required to have a liquidity of pH 1-8, but when used as a semi-solid or liquid, the stability of ascorbic acids, low irritation to skin and mucous membranes, and From the viewpoint of good skin usability, it is preferably an acidic region of pH 2-7, more preferably pH 2-6.
本発明のコラーゲン合成促進用組成物は、本発明の効果を奏すれば特に限定されないが、例えば医薬品、医薬部外品、食品[菓子、健康食品、栄養補助食品(バランス栄養食、サプリメントなど)を含む)、栄養機能食品、特定保健用食品を含む]、化粧品ではファンデーション、口紅、マスカラ、アイシャドウ、アイライナー、眉墨及び美爪料等のメーキャップ化粧料;乳液、クリーム、ローション、オイル及びパックなどの基礎化粧料;洗顔料やクレンジング、ボディ洗浄料などの洗浄料、入浴剤などとすることができる。 The composition for promoting collagen synthesis of the present invention is not particularly limited as long as the effect of the present invention is achieved. For example, pharmaceuticals, quasi drugs, foods [confectionery, health foods, nutritional supplements (balance nutritional foods, supplements, etc.) ), Nutritional functional foods, and foods for specified health use], cosmetics such as foundation, lipstick, mascara, eye shadow, eyeliner, eyebrow, and nail care cosmetics; emulsions, creams, lotions, oils and packs Basic cosmetics such as: facial cleansers, cleansings, body cleansers, bathing agents, etc.
本発明のコラーゲン合成促進用組成物は内服用組成物として用いても外用組成物として用いてもよいが、本発明は外用組成物として使用されることが好ましい。本発明の組成物はコラーゲン合成量が顕著に増大しているのでコラーゲン減少に伴う各種障害(角膜潰瘍などの角膜障害、リューマチ,関節炎,変形性関節炎,骨関節炎などの関節障害、炎症性障害等)の治療又は予防用組成物、美容上の問題を予防又は治療するための組成物(抗シワ用組成物、抗タルミ用組成物等)として用いることができる。 The composition for promoting collagen synthesis of the present invention may be used as an internal composition or an external composition, but the present invention is preferably used as an external composition. Since the composition of the present invention significantly increases the amount of collagen synthesis, various disorders associated with collagen decrease (corneal disorders such as corneal ulcers, rheumatoid arthritis, osteoarthritis, osteoarthritic joint disorders, inflammatory disorders, etc. ) Or a composition for preventing or treating cosmetic problems (an anti-wrinkle composition, an anti-tarmi composition, etc.).
以下に本発明を実施例及び試験例に基づいてさらに詳細に説明するが、本発明はこれら実施例等に限定されるものではない。なお、下記の各処方において%とは、特に言及しない限り、重量(W/W)%を意味するものとする。 Hereinafter, the present invention will be described in more detail based on examples and test examples, but the present invention is not limited to these examples. In the following formulations,% means weight (W / W)% unless otherwise specified.
試験例1 皮膚線維芽細胞におけるコラーゲン合成量
24ウェル培養プレート上に、正常ヒト皮膚線維芽細胞(NHDF;クラボウ社製)を1×104個/ウェルで播種し(1群を6とした)、培養液として皮膚線維芽細胞増殖用培地(クラボウ社製)を使用し、37℃、5%CO2条件下で培養した。96時間培養後、各ウェルから培養液を除去した後、L−アスコルビン酸又は/及びトリメチルグリシンを表1に示す濃度で含む上記培養液、又はL−アスコルビン酸及びトリメチルグリシンを含まない上記培養液(対照)を各ウェルに1ml加え、さらに48時間培養した。
培養終了後、培養上清中のI型プロコラーゲン量をELISA(Procollagen typeI C-peptide EIA Kit;宝酒造社製)にて測定した。I型プロコラーゲンは、I型コラーゲンの前駆体であることから、コラーゲン合成量の生化学的指標としてI型プロコラーゲン量を測定した。
次に、MTT試薬(ドータイトMTT凍結乾燥品;株式会社同仁化学研究所)を用いて各ウェルの細胞数を測定し、I型プロコラーゲン量を細胞数で除して、ウェル間の細胞数によるばらつきを排除するとともに、細胞あたりのコラーゲン合成量とした。
結果を表1に示す。表中のコラーゲン合成倍率は、対照培養液における細胞あたりのコラーゲン合成量(1群6の平均値)に対する試験培養液における細胞あたりのコラーゲン合成量(1群6の平均値)の倍率とする。
Test Example 1 Collagen synthesis amount in skin fibroblasts Normal human skin fibroblasts (NHDF; manufactured by Kurabo Industries) were seeded at 1 × 10 4 cells / well on a 24-well culture plate (1 group was defined as 6). Then, a culture medium for dermal fibroblast proliferation (manufactured by Kurabo Industries) was used as a culture solution and cultured at 37 ° C. under 5% CO 2 . After culturing for 96 hours, after removing the culture solution from each well, the above culture solution containing L-ascorbic acid and / or trimethylglycine at the concentrations shown in Table 1, or the above culture solution not containing L-ascorbic acid and trimethylglycine 1 ml of (control) was added to each well and further cultured for 48 hours.
After completion of the culture, the amount of type I procollagen in the culture supernatant was measured by ELISA (Procollagen type I C-peptide EIA Kit; manufactured by Takara Shuzo). Since type I procollagen is a precursor of type I collagen, the amount of type I procollagen was measured as a biochemical indicator of the amount of collagen synthesis.
Next, the number of cells in each well was measured using MTT reagent (Dotite MTT freeze-dried product; Dojindo Laboratories Co., Ltd.), the amount of type I procollagen was divided by the number of cells, and the number of cells between the wells While excluding variations, the amount of collagen synthesis per cell was used.
The results are shown in Table 1. The collagen synthesis ratio in the table is the ratio of the collagen synthesis amount per cell (average value per group 6) in the test culture solution to the collagen synthesis amount per cell (average value per group 6) in the control culture medium.
L−アスコルビン酸添加培養液で培養した細胞では、L−アスコルビン酸濃度に依存してコラーゲン合成量が増加していた。一方、トリメチルグリシン添加培養液で培養した細胞では、コラーゲン合成量の増加が認められなかった。L−アスコルビン酸とトリメチルグリシンの両者を併用した培養液で培養した細胞では、コラーゲン合成量が顕著に増加したことから、トリメチルグリシンとL−アスコルビン酸の併用によってコラーゲン合成促進効果が顕著に増強されることが認められた。 In the cells cultured in the L-ascorbic acid-added culture solution, the amount of collagen synthesis increased depending on the L-ascorbic acid concentration. On the other hand, no increase in the amount of collagen synthesis was observed in cells cultured in a culture solution containing trimethylglycine. In cells cultured in a culture medium in which both L-ascorbic acid and trimethylglycine are used in combination, the amount of collagen synthesis is remarkably increased. Therefore, the combined use of trimethylglycine and L-ascorbic acid significantly enhances the collagen synthesis promoting effect. It was recognized that
実施例1(日焼け止め)
トリメチルグリシン 1.0(%)
テトラ2−ヘキシルデカン酸アスコルビル 0.1
パラメトキシケイ皮酸2−エチルヘキシル 10.0
デカメチルシクロペンタシロキサン 20.0
パルミチン酸オクチル 10.0
ポリオキシエチレン・メチルポリシロキサン共重合体 3.0
メチルハイドロジェンポリシロキサン処理低温焼成酸化亜鉛 15.0
ポリアクリル酸アルキル 5.0
濃グリセリン 5.0
無水エタノール 5.0
1,3−ブチレングリコール 3.0
パンテノール 0.1
香料 0.1
フィチン酸 0.05
精製水 残 量
合 計 100.0%。
Example 1 (sunscreen)
Trimethylglycine 1.0 (%)
Ascorbyl tetra-2-hexyldecanoate 0.1
2-Ethylhexyl paramethoxycinnamate 10.0
Decamethylcyclopentasiloxane 20.0
Octyl palmitate 10.0
Polyoxyethylene / methylpolysiloxane copolymer 3.0
Low-temperature baked zinc oxide treated with methylhydrogenpolysiloxane 15.0
Polyalkyl acrylate 5.0
Concentrated glycerin 5.0
Absolute ethanol 5.0
1,3-butylene glycol 3.0
Panthenol 0.1
Fragrance 0.1
Phytic acid 0.05
Remaining amount of purified water 100.0% in total.
実施例2(日焼け止め)
トリメチルグリシン 3.0(%)
テトラ2−ヘキシルデカン酸アスコルビル 1.0
パラメトキシケイ皮酸2−エチルヘキシル 10.0
ベンジリデンマロネートポリシロキサン(PARSOL SLX) 5.0
ジエチルアミノヒドロキシベンゾイルヘキシルベンゾエート
(ユビナール APlus) 5.0
ジメトキシベンジリデンオキソイミダゾリジンプロピオン酸2−エチルヘキシル
3.0
2,4,6−トリス[4−(2−エチルヘキシルオキシカルボニル)アニリノ]−1,3,5−トリアジン 3.0
ジオクタン酸イソルバイド(ソルエスター208) 10.0
ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコン
(KF6105) 3.0
フェルラ酸 3.0
パラオキシ安息香酸メチル 0.05
パラオキシ安息香酸プロピル 0.05
フェニルベンズイミダゾールスルホン酸 3.0
トリエタノールアミン 1.5
シアノコバラミン 0.05
精製水 残 量
合 計 100.0%。
Example 2 (sunscreen)
Trimethylglycine 3.0 (%)
Ascorbyl tetra-2-hexyldecanoate 1.0
2-Ethylhexyl paramethoxycinnamate 10.0
Benzylidene malonate polysiloxane (PARSOL SLX) 5.0
Diethylaminohydroxybenzoyl hexyl benzoate
(Yubinar APlus) 5.0
2-methoxyhexyl dimethoxybenzylideneoxoimidazolidinepropionate
3.0
2,4,6-Tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine 3.0
Dioctanoic acid isorubide (Solester 208) 10.0
Lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone (KF6105) 3.0
Ferulic acid 3.0
Methyl paraoxybenzoate 0.05
Propyl paraoxybenzoate 0.05
Phenylbenzimidazolesulfonic acid 3.0
Triethanolamine 1.5
Cyanocobalamin 0.05
Purified water balance
Total 100.0%.
実施例3(日焼け止め)
トリメチルグリシン 5.0(%)
テトラ2−ヘキシルデカン酸アスコルビル 5.0
アスコルビン酸ナトリウム 1.0
リン酸L−アスコルビルマグネシウム 3.0
フェルラ酸 3.0
フェニルベンズイミダゾールスルホン酸 3.0
トリエタノールアミン 1.5
ヒドロキシメトキシベンゾフェノンスルホン酸 1.0
ラウリルジメチコンポリグリセリン−3クロスポリマー/トリ2−エチルヘキサン酸グリセリル(KSG−830) 5.0
濃グリセリン 10.0
シアノコバラミン 0.05
パラメトキシケイ皮酸2−エチルヘキシル 10.0
4−tert−ブチル−4−メトキシジベンゾイルメタン 2.0
トリ2−エチルヘキサン酸グリセリル 5.0
パラオキシ安息香酸メチル 0.05
パラオキシ安息香酸プロピル 0.05
デカメチルシクロペンタシロキサン 15.0
精製水 残 量
合 計 100.0%。
Example 3 (sunscreen)
Trimethylglycine 5.0 (%)
Ascorbyl tetra-2-hexyldecanoate 5.0
Sodium ascorbate 1.0
L-ascorbyl magnesium phosphate 3.0
Ferulic acid 3.0
Phenylbenzimidazolesulfonic acid 3.0
Triethanolamine 1.5
Hydroxymethoxybenzophenonesulfonic acid 1.0
Lauryl dimethicone polyglycerin-3 crosspolymer / glyceryl tri-2-ethylhexanoate (KSG-830) 5.0
Concentrated glycerin 10.0
Cyanocobalamin 0.05
2-Ethylhexyl paramethoxycinnamate 10.0
4-tert-Butyl-4-methoxydibenzoylmethane 2.0
Glyceryl tri-2-ethylhexanoate 5.0
Methyl paraoxybenzoate 0.05
Propyl paraoxybenzoate 0.05
Decamethylcyclopentasiloxane 15.0
Purified water balance
Total 100.0%.
実施例4(シワ・タルミ予防クリーム)
トリメチルグリシン 0.5(%)
テトラ2−ヘキシルデカン酸アスコルビル 5.0
ラウリルジメチコンポリグリセリン−3クロスポリマー/トリ2−エチルヘキサン酸グリセリル(KSG−830) 5.0
架橋型メチルポリシロキサン/メチルポリシロキサン(KSG16)5.0
架橋型アルキル変性シリコン/トリ2−エチルヘキサン酸グリセリル
(KGG−43) 3.0
デカメチルシクロペンタシロキサン 15.0
ポリメチルシルセスキオキサン 3.0
(ジメチコン/ビニルジメチコン/メチコン)クロスポリマー 1.0
ポリアクリル酸アルキル 5.0
濃グリセリン 10.0
硫酸マグネシウム 0.1
エデト酸ナトリウム 0.05
シアノコバラミン 0.01
パラオキシ安息香酸メチル 0.05
パラオキシ安息香酸プロピル 0.05
精製水 残 量
合 計 100.0%。
Example 4 (wrinkle and tarmi prevention cream)
Trimethylglycine 0.5 (%)
Ascorbyl tetra-2-hexyldecanoate 5.0
Lauryl dimethicone polyglycerin-3 crosspolymer / glyceryl tri-2-ethylhexanoate (KSG-830) 5.0
Cross-linked methylpolysiloxane / methylpolysiloxane (KSG16) 5.0
Cross-linked alkyl-modified silicon / glyceryl tri-2-ethylhexanoate (KGG-43) 3.0
Decamethylcyclopentasiloxane 15.0
Polymethylsilsesquioxane 3.0
(Dimethicone / vinyl dimethicone / methicone) cross polymer 1.0
Polyalkyl acrylate 5.0
Concentrated glycerin 10.0
Magnesium sulfate 0.1
Sodium edetate 0.05
Cyanocobalamin 0.01
Methyl paraoxybenzoate 0.05
Propyl paraoxybenzoate 0.05
Purified water balance
Total 100.0%.
実施例5(シワ・タルミ予防クリーム)
トリメチルグリシン 0.1(%)
テトラ2−ヘキシルデカン酸アスコルビル 3.0
テトラ2−エチルヘキサン酸ペンタエリスリット 5.0
白色ワセリン 2.0
ステアリン酸ポリオキシエチレンソルビタン 2.0
カルボキシビニルポリマー 0.1
1,3−ブチレングリコール 5.0
セタノール 0.5
濃グリセリン 5.0
シアノコバラミン 0.01
L−アルギニン 0.1
キサンタンガム 0.1
ヒドロキシエチルセルロース 0.1
アルギン酸ナトリウム 0.1
パラオキシ安息香酸メチル 0.05
パラオキシ安息香酸プロピル 0.05
精製水 残 量
合 計 100.0%。
Example 5 (wrinkle and tarmi prevention cream)
Trimethylglycine 0.1 (%)
Ascorbyl tetra-2-hexyldecanoate 3.0
Tetra-2-ethylhexanoic acid pentaerythrit 5.0
White petrolatum 2.0
Polyoxyethylene sorbitan stearate 2.0
Carboxyvinyl polymer 0.1
1,3-butylene glycol 5.0
Cetanol 0.5
Concentrated glycerin 5.0
Cyanocobalamin 0.01
L-Arginine 0.1
Xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Sodium alginate 0.1
Methyl paraoxybenzoate 0.05
Propyl paraoxybenzoate 0.05
Purified water balance
Total 100.0%.
実施例6(シワ・タルミ予防化粧水)
トリメチルグリシン 3.0(%)
アスコルビン酸ナトリウム 10.0
リン酸L−アスコルビルマグネシウム 5.0
ヒアルロン酸 0.05
1,3−ブチレングリコール 5.0
ポリオキシエチレン硬化ヒマシ油(HCO−80) 1.0
パラオキシ安息香酸メチル 0.05
精製水 残 量
合 計 100.0%。
Example 6 (wrinkle and tarmi prevention lotion)
Trimethylglycine 3.0 (%)
Sodium ascorbate 10.0
L-ascorbyl magnesium phosphate 5.0
Hyaluronic acid 0.05
1,3-butylene glycol 5.0
Polyoxyethylene hydrogenated castor oil (HCO-80) 1.0
Methyl paraoxybenzoate 0.05
Purified water balance
Total 100.0%.
実施例7(シワ・タルミ予防スティック)
トリメチルグリシン 3.0(%)
テトラ2−ヘキシルデカン酸アスコルビル 5.0
パラフィンワックス 10.0
白色ワセリン 15.0
オレイン酸フィトステリル 19.0
セリシン 5.0
カルナバロウ 5.0
サラシミツロウ 5.0
ホホバ油 10.0
l−メントール 0.1
トリ2−エチルヘキサン酸グリセリル 22.9
合 計 100.0%。
Example 7 (wrinkle and tarmi prevention stick)
Trimethylglycine 3.0 (%)
Ascorbyl tetra-2-hexyldecanoate 5.0
Paraffin wax 10.0
White petrolatum 15.0
Phytosteryl oleate 19.0
Sericin 5.0
Carnavalou 5.0
Sara honey bees 5.0
Jojoba oil 10.0
l-Menthol 0.1
Glyceryl tri-2-ethylhexanoate 22.9
Total 100.0%.
Claims (4)
The external composition for promoting collagen synthesis according to claim 3, wherein 0.1 to 20 parts by weight of trimethylglycine is contained per 1 part by weight of ascorbic acid.
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JP2002060313A (en) * | 2000-08-16 | 2002-02-26 | Shiseido Co Ltd | Skin care preparation |
JP2002145759A (en) * | 2000-08-28 | 2002-05-22 | Shiseido Co Ltd | Skin care preparation |
JP2002145719A (en) * | 2000-11-07 | 2002-05-22 | Toyo Beauty Kk | Cosmetic material |
JP3782779B2 (en) * | 2000-12-28 | 2006-06-07 | 株式会社資生堂 | Topical skin preparation |
JP2003252718A (en) * | 2002-03-01 | 2003-09-10 | Shiseido Co Ltd | In vivo dihydroxyindole compound polymerization inhibitor |
JP2003063944A (en) * | 2001-08-28 | 2003-03-05 | Shiseido Co Ltd | Skin care preparation and melanogenesis inhibitor |
JP3821785B2 (en) * | 2002-05-14 | 2006-09-13 | 株式会社コーセー | Water-containing powder cosmetic |
JP2003335665A (en) * | 2002-05-21 | 2003-11-25 | Fancl Corp | Composition for regulating in vivo vitamin c level |
-
2004
- 2004-02-27 JP JP2004052661A patent/JP5241054B2/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010248211A (en) * | 2010-06-10 | 2010-11-04 | Rohto Pharmaceut Co Ltd | Composition for enhancing collagen synthesis |
KR101562368B1 (en) | 2014-05-27 | 2015-10-20 | (주)에이씨티 | Cosmetic composition comprising the biomimetic complex as active ingredient |
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JP2005239645A (en) | 2005-09-08 |
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