JP2002145719A - Cosmetic material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic material, not incorporated with a disinfectant or having its smaller amount than a normal amount, excellent in safety and use feeling, and having a high antibacterial property. SOLUTION: This cosmetic material is obtained by containing 0.01-20 wt.% following component (A) and component (B) as essential components, and being adjusted at pH 3.5-7.0. (A) A salt such as an alkali metal salt, ammonium salt or amine salt of p-hydroxycinnamic acid or 4-hydroxycinnamic acid, or a component of using both substances simultaneously. (B) A 2-4C lower monohydric alcohol or a 2-6C and 2-30 polyhydric alcohol or a component of using both substances simultaneously. The cosmetic material has no problem in its use feeling and skin irritating property, becomes a cosmetic having an extremely high antibacterial property and also becomes a skin cosmetic material exhibiting extremely few generation of troubles on the skin and a high safety.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics having improved safety, feeling of use and preservability.

[0002]

2. Description of the Related Art In general, preservatives are blended in cosmetics for the purpose of storage stability. As a preservative, for example, p
-Hydroxybenzoic acid ester, benzoic acid or a salt thereof, sorbic acid or a salt thereof, sodium dehydroacetate and the like. These preservatives are generally blended in such a manner that the amount of the preservative is as low as possible to secure the storage stability of the cosmetic and to reduce skin troubles due to irritation.

[0003] Cosmetics using a p-hydroxycinnamic acid derivative or the like as a component for preventing melanin pigmentation of the skin are disclosed in JP-A-5-105620 and the like.

[0004]

However, in these prior arts, p-hydroxycinnamic acid is used only as an active ingredient of a whitening cosmetic.
p-Hydroxycinnamic acid is only known for its effect on preventing pigmentation.

[0005] Further, if the above-mentioned p-hydroxybenzoic acid ester and other conventional preservatives are incorporated into cosmetics, skin troubles may occur, and the preservatives are gentle and highly safe to the skin. It was difficult to obtain a rich cosmetic.

[0006] Some cosmetics do not contain preservatives, but the product form of these cosmetics is limited to only specific ones, and the addition of such cosmetics is costly. In addition, there is a disadvantage that it is difficult to give a feeling of use of the cosmetic.

[0007] Therefore, an object of the present invention is to solve the above-mentioned problems, and disadvantageous to the safety and feeling of use of cosmetics without adding a preservative or using a smaller amount than usual. An object of the present invention is to provide a cosmetic composition having no antibacterial properties and high antibacterial properties.

[0008]

In order to solve the above-mentioned problems, the present invention comprises the following components (A) and (B) as essential components and is adjusted to pH 3.5 to 7.0. It was a cosmetic. (A) p-Hydroxycinnamic acid or a salt thereof or a component in which both are used (B) A lower monohydric alcohol or a polyhydric alcohol or a component in which both are used The cosmetic of the present invention constituted as described above has a predetermined component. By containing (A) and (B) as essential components and adjusting the pH to 3.5 to 7.0, there is no problem in feeling of use or skin irritation, and high antibacterial properties such as antiseptic effect. And a highly safe skin cosmetic with few occurrences of troubles on the skin.

In order to obtain a cosmetic having the above-mentioned effects, the lower monohydric alcohol is a monohydric alcohol having 2 to 4 carbon atoms, and the polyhydric alcohol is a monohydric alcohol having 2 to 4 carbon atoms.
It is preferably a polyhydric alcohol having 6 and 2 to 3 oxygen atoms.

[0010] The cosmetic of the present invention may be one wherein the salt of p-hydroxycinnamic acid is an alkali metal salt, ammonium salt or amine salt of 4-hydroxycinnamic acid.

[0011] The cosmetic of the present invention comprises the component (A)
Is preferably from 0.01 to 20% by weight to more reliably achieve the effects of the present invention.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, p-hydroxycinnamic acid to be incorporated in cosmetics is represented by 3-UPAC nomenclature.
(4-hydroxyphenyl) -cis-2-propenoic acid or 3- (4-hydroxyphenyl) -trans-2
-Refers to propenoic acid or mixtures thereof. The salts of p-hydroxycinnamic acid refer to one or more of alkali metal salts, ammonium salts, and amine salts thereof, and the alkali metal salts referred to herein include alkali metals such as lithium, sodium, and potassium. It is a salt with p-hydroxycinnamic acid, and particularly, a sodium salt of p-hydroxycinnamic acid and a potassium salt of p-hydroxycinnamic acid are representative.

The amine salt of p-hydroxycinnamic acid includes salts of a basic amino acid such as arginine, histidine and lysine with p-hydroxycinnamic acid, triethanolamine, 2-amino-2-methyl-1, A salt of a hydroxyamine compound such as 3-propanediol or 2-amino-2-methyl-1-propanol with p-hydroxycinnamic acid.

In the present invention, the amount of p-hydroxycinnamic acid and / or its salt to be incorporated into the cosmetic is 0.01 to 20% by weight, preferably 0.05 to 10% by weight in the cosmetic.
A blending amount of% by weight is desirable. When the amount is less than 0.01% by weight, the antibacterial effect is small, and when the amount is more than 20% by weight, it becomes difficult to give the cosmetic a specific feeling of use.

The lower monohydric alcohol to be incorporated in the cosmetic of the present invention is a monohydric alcohol having 2 to 4 carbon atoms, such as ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol and 1-methyl. Propanol,
It refers to 1,1-dimethylethanol, particularly preferably ethanol and 2-propanol, which are widely used in cosmetics.

The polyhydric alcohol in the present invention is a polyhydric alcohol having 2 to 6 carbon atoms and 2 to 3 oxygen atoms, such as ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-
Butylene glycol, 1,4-butylene glycol,
1,2-Pentanediol, 1,2-hexanediol, 3-methyl-1,3-butanediol, glycerin and the like are generally used, but are not particularly limited. 1 of alcohol
A species or two or more species.

[0017] The amount of the lower monohydric alcohol and / or polyhydric alcohol of the present invention is difficult to clearly limit because the appropriate amount varies depending on the cosmetics. .1% by weight or more is required. And, in order to enhance the antibacterial property and the solubility, such a compounding amount is desirably at least the same weight as p-hydroxycinnamic acid and / or its salts.

In the present invention, in order to adjust the cosmetics to an appropriate pH range, cosmetics such as lotion, face wash, shampoo, rinse, treatment, hair styling, hair tonic and the like, and creams and emulsions of oil-in-water type cosmetics are used. In such cosmetics, the pH of these cosmetics themselves may be adjusted, and in the case of creams or emulsions of water-in-oil cosmetics, the pH of the aqueous phase may be adjusted. In the present invention, a suitable pH range is from 3.5 to 7.0, and more preferably from 4.0 to 6.5.
It is. The reason is that when the pH is lower than 3.5, the antibacterial property is excellent, but the skin trouble due to the stimulus reaction is high. Similarly, when the pH is 9 or more, the skin trouble due to the stimulus reaction is high. At pH 7 to 9, skin irritation due to a stimulus reaction is unlikely to occur, but antibacterial properties are low regardless of the presence or absence of p-hydroxycinnamic acid and / or its salts.

The cosmetics of the present invention include skin cosmetics (including quasi-drugs) such as lotions, emulsions, creams, and facial cleansers, as well as hair cosmetics such as shampoos, rinses, treatments, hair styling, and hair tonics. (Including quasi-drugs), and makeup cosmetics (including quasi-drugs) such as foundations, etc., and are particularly limited as long as they can be used as cosmetics in general. Not something.

Among the materials used in cosmetics, base materials include water, vegetable oils, animal oils, fats such as vegetable fats, animal liquid waxes, animal solid waxes, vegetable solid waxes, and mineral solid waxes. Waxes, liquid paraffin, vaseline, ceresin, paraffin wax, microcrystalline wax, hydrocarbons such as squalane, fatty acids, higher alcohols, esters, metal soaps, silicone oils,
Activators such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants,
Colorants such as tar pigments, inorganic pigments, organic pigments, and natural pigments; flavors such as natural flavors, synthetic flavors, and compounded flavors; vitamins such as vitamins, vitamin derivatives, and provitamins;
Extraction components such as photosensitizers, animal extract components, plant extract components, ultraviolet absorbers, antioxidants, chelating agents, buffers, astringents, neutralizers, antibacterial agents, carbohydrates , Natural polymers, polymers such as synthetic polymers, whitening agents, anti-inflammatory agents, humectants such as urea, trimethylglycine, DL-pyrrolidonecarboxylic acid, polyethylene glycol and diglycerin. However, it is not limited to these various components.

The cosmetic according to the embodiment of the present invention has a high preservative effect even if the amount of the preservative such as p-hydroxybenzoate is reduced from the usual amount or is not used. It is also possible to add preservatives, if necessary, for preparation.

[0022]

Examples and Comparative Examples [Examples 1 to 3] As shown in Table 1, p-hydroxycinnamic acid and / or its salts were used as lower monohydric alcohol and / or polyhydric alcohol using p-hydroxycinnamic acid. , Ethanol, 1,
3-butylene glycol and glycerin were used, and potassium hydroxide was used as a pH adjuster. The lotion was prepared by a conventional method.

The following tests were performed on the obtained lotion, and the results are also shown in the table. [Antibacterial test (antiseptic properties of cosmetics)] Antibacterial tests include Escherichia coli and Staphylococcus aureus: Staphylo.
coccus aureus), Bacillus subtilis: B
acillus subtilis) and a mixed bacterium of Pseudomonas aeruginosa were inoculated at about 3 × 10 ⁶ CFU / g of lotion and stored at 30 ° C. for 2 days. This was cultured and the number of viable bacteria was measured. "○" when the viable cell count was less than 1/1000 of the inoculated number, "△" when the viable cell number was less than 1/100 of the inoculated number,
When the number of viable bacteria was 1/100 or more of the number of inoculated cells, "x" was marked and evaluated on a three-point scale. [Usability test] The usability test was conducted by a total of 35 people, including 15 specialized panels and 20 general panels, and if more than 4 (10%) answered that the usability was not good, a "x" was given.
And those not so were marked with “○”. [Skin irritation test] Skin irritation was measured when a total of 35 people, 15 professional panelists and 20 general panelists of the usability test, who answered that there was irritation during use were 4 or more. ×, 3 or less were evaluated as “○”.

[0024]

[Table 1]

As is clear from the results shown in Table 1, p-hydroxycinnamic acid was added and p-hydroxycinnamic acid was added to the mixture using potassium hydroxide.
Examples 1 to 3 in which the H adjustment was performed are high antibacterial properties, good feeling in use, and a skin irritant with low skin irritation. In particular, Example 1 has a refreshing feeling in use and is a non-alcohol type. Example 3 had a moist feeling, and Example 2 had an intermediate good feeling.

Comparative Examples 1 to 3 (No p-hydroxycinnamic acid blended) In addition to the mixing ratios shown in Table 2, Examples 1 to 3 were used.
The lotions of Comparative Examples 1 to 3 which were prepared in substantially the same manner as in Example 1 had no p-hydroxycinnamic acid, and had not been pH-adjusted with potassium hydroxide. The above test was performed on the obtained lotion, and the results are shown in the table.

[0027]

[Table 2]

As is clear from the results shown in Table 2, Comparative Examples 1 to 3 containing no p-hydroxycinnamic acid had the same feeling in use and skin irritation as in the Examples, but had poor antibacterial properties. was there.

[Comparative Examples 4 to 6 (pH less than 3.5)] Table 3
The lotions of Comparative Examples 4 to 6 which were prepared in substantially the same manner as Examples 1 to 3 except that the mixing ratios shown in Table 3 were not adjusted, and the pH of the lotions of Examples 1 to 3 was not adjusted. 3 or more and less than 3.5. The above test was performed on the obtained lotion, and the results are shown in the table.

[0030]

[Table 3]

As a result, in Comparative Examples 4 to 6, although the feeling of use and the antibacterial properties were as good as those of the examples, the results of Examples 1 to 3 were good.
There was a drawback that skin irritation was higher than that of

[Comparative Example 7 (pH 7 or higher), Comparative Example 8 (Lower monohydric alcohol-free and polyhydric alcohol-free)] The mixing ratio shown in Table 4 was used. Comparative Example 7 was adjusted to pH 7 or higher. In Example 8, a lotion was prepared in substantially the same manner as in Examples 1 to 3, except that the lower monohydric alcohol was not blended and the polyhydric alcohol was not blended.
The above test was performed on the obtained lotion, and the results are shown in the table.

[0033]

[Table 4]

As is clear from the results shown in Table 4, the lotions of Comparative Examples 7 and 8 were prepared by adjusting the pH of the lotion of Example 3 to 7.3. Although it was as good as the example, there was a disadvantage that the antibacterial property was low as compared with the examples 1 to 3. In addition, the lotion of Comparative Example 8 was prepared without blending the lower monohydric alcohol and the polyhydric alcohol without the lotion of Examples 1 to 3, and the feeling of use and skin irritation were as good as in the example. However, Examples 1 to
There was a disadvantage that the antibacterial property was slightly lower than that of No. 3.

Example 4, Comparative Examples 9 to 10 (paraben blending) As shown in Table 5, Comparative Examples 9 and 10
Is a type of p-hydroxybenzoic acid ester which is generally known and used as a preservative, in which the pH of the lotion of Example 3 was not adjusted with potassium hydroxide without p-hydroxycinnamic acid. Of methyl paraben. Example 1 except that the mixing ratio shown in Table 5 was used.
The preparation was performed in substantially the same manner as in Nos. 1 to 3 to prepare a lotion. The above test was performed on the obtained lotion, and the results are shown in the table.

[0036]

[Table 5]

As is clear from the results in Table 5, as a result of the antibacterial test, it was found that the antibacterial property was poor when methyl paraben was 0.05%, and was inferior to that of Example 3 even when 0.1%.

However, it was found that the antibacterial property of Example 4 in which the present invention was used in combination with Comparative Example 9 containing 0.05% of methylparaben was better than that of 0.1% of methylparaben of Comparative Example 10.

[Comparative Examples 11 to 13 (without p-hydroxycinnamic acid and without preservatives and having antiseptic properties)] Table 6 shows the proportions of p-hydroxycinnamic acid and no ethanol. Comparative Examples 11 to 13 having antiseptic skin lotion were prepared in the same manner as the other examples. The above test was performed on the obtained lotion, and the results are shown in the table.

[0040]

[Table 6]

As is clear from the results shown in Table 6, Comparative Examples 11 to 13 have high antibacterial properties, but have a drawback that they have a much worse feeling in use than Examples 1 to 3 and also have high skin irritation. there were.

The cosmetics according to the present invention include, in addition to the above-mentioned lotion, skin cosmetics (including quasi-drugs) such as milky lotions, creams and facial cleansers, shampoos, rinses,
It can be provided for hair cosmetics (including quasi-drugs) such as treatments, hair styling, and hair tonics, and makeup cosmetics (including quasi-drugs) such as foundations.

The following are examples of compositions of cosmetics which are examples other than lotion and have good feeling in use, skin irritation and antiseptic properties.

Example 5: Shampoo Coconut oil fatty acid amidopropyl betaine solution (30% aqueous solution) 18.0 N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine solution (30% aqueous solution) 15.0 Polyoxyethylene ( 3EO) Disodium lauryl sulfosuccinate (32% aqueous solution) 12.0 Palm oil fatty acid diethanolamide 4.0 Ethanol 3.0 1,2-Pentanediol 3.0 Glycerin 2.0 p-Hydroxycinnamic acid 0 Polyoxyethylene (60EO) hydrogenated castor oil 1.0 O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethylcellulose 0.1 Lavender oil 0.2 Ethylenediaminetetraacetic acid tetrasodium salt 0.1 Citric acid or sodium hydroxide (adjusted to pH 5.5) To) qs Purified water Balance (wt%)

Example 6 Hair Tonic Ethanol 40.0 1,2-Pentanediol 2.0 p-Hydroxycinnamic Acid 1.0 Polyoxyethylene (40EO) Hydrogenated Castor Oil 0.5 L-Menthol 05 Lavender oil 0.05 DL-α-tocopherol acetate 0.05 Ammonia water (adjust to pH 5.5) Appropriate amount Purified water Remaining amount (% by weight)

Example 7: Facial Cleanser Potassium N-coconut fatty acid acyl-L-glycine 35.0 Ethylene glycol distearate 2.0 Glycerin 20.0 1,3-butylene glycol 5.0 p-Hydroxycinnamic acid 0 Sorbit solution (70% aqueous solution) 20.0 Citric acid (adjust to pH 6.0) Appropriate amount Perfume 0.1 Purified water Remaining amount (% by weight)

Example 8: Emulsion Xanthan gum 0.05 Glycerin 6.00 Methyl parahydroxybenzoate 0.15 1,2-Pentanediol 2.00 Carboxyvinyl polymer 0.15 1,3-butylene glycol 5.00 Ethanol 3. 00 (Adipic acid / 2-ethylhexanoic acid / stearic acid) glyceryl oligoester 2.00 Glyceryl tri-2-ethylhexanoate 2.00 Shea butter 1.00 Squalane 3.00 Cetanol 0.30 Tetra-2- Ascorbyl hexyldecanoate 1.00 Vitamin E 0.02 Hydrogenated soybean phospholipid 0.20 Polyglyceryl monomyristate 0.30 Polyglyceryl monolaurate 0.40 L-arginine (adjust to pH 6.0) Appropriate amount p-hydroxycinnamic acid 1 .00 Fragrance 0.05 Purified water balance (% by weight)

Example 9: Emollient cream Glycerin 5.00 Trimethylglycine 1.00 Ethanol 5.00 Dipropylene glycol 10.00 1,2-Pentanediol 5.00 Xanthan gum 0.15 Carboxyvinyl polymer 0.16 Methyl polysiloxane 2.00 Stearic acid 3.00 Cetostearyl alcohol 1.50 Shea butter 1.00 Isotridecyl isononanoate 2.00 Glyceryl tri-2-ethylhexanoate 4.00 Glycerin fatty acid ester 3.00 Polyglyceryl diisostearate 0.50 Monolauric acid Polyglyceryl 0.50 Ascorbyl tetra-2-hexyldecanoate 1.00 2-Amino-2-methyl-1-propanol (adjust to pH 5.5) qs p-hydroxycinnamic acid 0 Perfume 0.05 Purified water Balance (wt%)

Example 10: Sunscreen lotion shaking type Alumina silica-treated fine particle titanium oxide 4.00 Alumina silica-treated fine particle titanium oxide 4.00 Zinc oxide 3.00 Sericite 3.00 3-methyl-1,3-butane Diol 15.00 1,3-butylene glycol 10.00 1,2-pentanediol 2.00 isotridecyl isononanoate 2.00 methylpolysiloxane 1.00 p-hydroxycinnamic acid 3.00 2-amino-2-methyl- 1-propanol (adjust to aqueous phase pH 5.5) suitable amount Perfume 0.05 purified water remaining (wt%)

[0050]

As described above, the present invention contains the predetermined components (A) and (B) as essential components,
Because it was a cosmetic adjusted to H value, without adding preservatives,
Alternatively, even when the amount is smaller than usual, there is an advantage that there is no disadvantage in safety and feeling of use of the cosmetic and that the cosmetic has high antibacterial properties.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification Symbol FI Theme Court ゛ (Reference) A61K 7/42 A61K 7/42 7/48 7/48 7/50 7/50 (72) Inventor Yuji Shibayama 3-13-8 Higashinakamoto, Higashinaka-ku, Osaka Toyo Beauty Corporation F-term (reference) 4C083 AA122 AB032 AB082 AB212 AB242 AB432 AC022 AC072 AC102 AC112 AC122 AC132 AC242 AC302 AC311 AC312 AC352 AC392 AC422 AC432 AC482 AC532 AC542 AC582 AC642 AC662 AC712792 AD092 AD152 AD282 AD352 AD532 AD572 AD642 AD662 BB44 BB48 CC04 CC05 CC19 CC23 CC37 CC38 DD23 DD31 EE06 EE10 EE17 EE22

Claims (4)

[Claims] 1. A cosmetic comprising the following components (A) and (B) as essential components and adjusted to a pH of 3.5 to 7.0. (A) p-Hydroxycinnamic acid or a salt thereof or a component used in combination (B) Lower monohydric alcohol or polyhydric alcohol or a component used in combination 2. The lower monohydric alcohol is a monohydric alcohol having 2 to 4 carbon atoms, and the polyhydric alcohol is a polyhydric alcohol having 2 to 6 carbon atoms and 2 to 3 oxygen atoms.
The cosmetic described. 3. The cosmetic according to claim 1, wherein the salt of p-hydroxycinnamic acid is an alkali metal salt, ammonium salt or amine salt of 4-hydroxycinnamic acid. 4. The cosmetic according to claim 1, wherein the component (A) is 0.01 to 20% by weight.