CN108498382A

CN108498382A - A kind of moisturizing conveys nano-composition and its preparation method and application altogether

Info

Publication number: CN108498382A
Application number: CN201810690238.XA
Authority: CN
Inventors: 刘卫; 沈慧慧; 吴培诚; 闻庆; 陈家铃
Original assignee: Wuhan Bai Si Kay Biotechnology Co Ltd
Current assignee: Wuhan Bai Si Kay Biotechnology Co Ltd
Priority date: 2018-06-28
Filing date: 2018-06-28
Publication date: 2018-09-07

Abstract

The present invention provides a kind of moisturizings to convey nano-composition and its preparation method and application altogether, belongs to cosmetic technical field, and the moisturizing conveys the component that nano-composition includes following mass percentage altogether：0.1%~10% physiological lipid, 0.2%~10% emollient, 0.5%~25% hygroscopic agent, 0.1%~6% large biological molecule combined with water, 1%~20% liquid fat, 10%~50% emulsifier, 5%~30% assistant for emulsifying agent, the water of 0.01%~1% preservative and surplus；The grain size that the moisturizing conveys nano-composition altogether is 10~500nm.The present invention contains the different a variety of active ingredients of moisturizing mechanism in same nano-carrier, realizes transdermal total conveying, the collaboration moisture-keeping function of multiple target point multimachine moisturizing active constituent, has both skin moisture-keeping, stratum corneum barrier repairs double effects.

Description

A kind of moisturizing conveys nano-composition and its preparation method and application altogether

Technical field

The present invention relates to cosmetic technical fields more particularly to a kind of moisturizing to convey nano-composition and preparation method thereof altogether And application.

Background technology

With the growth at people's age, the moisture of skin is gradually lost in, and causes skin metabolism abnormal and aging, wrinkle occurs A series of skin problems of line and color spot etc..Therefore, skin moisture-keeping is the basis of skin texture gloss exquisiteness lubrication, is also skin The index prevented or slow down aging mostly important.

A kind of excellent moisturizing class cosmetics can not only increase epidermis water content, moreover it is possible to repair impaired skin barrier work( Can, mitigate dry skin, furfur allows rough skin to become smooth, soft.Different moisturizing active constituent, in skin Moisturizing mechanism is different.Currently used skin moisturizing ingredients can be divided into hygroscopic agent, sealer, emollient, the biology combined with water Macromolecular.The moisturizing of the present invention convey altogether active constituent in nano-composition except emollient, hygroscopic agent, is combined with water it is biological greatly Further include physiological lipid outside molecule, four class moisturizer are natural moisture preserving agent.

Physiological lipid is lipoid between the outermost corneocyte of human skin, and epidermal cell is helped closely to connect It closes, playing prevents moisture from distributing and having to outside stimulus the important function of safeguard function, is to maintain eubolism, keep skin water Divide important component.But with the variation of age or skin, physiological lipid synthesis amount can be reduced, and skin just will appear dry, quick Sense and aging.Ceramide, cholesterol, free fatty are the most basic constituent of physiological lipid, wherein ceramide Account for 50%.Percutaneous water loss (TEWL) reflects evaporation capacity of the moisture from skin surface, is the important symbol of skin barrier function. Ceramide amount is insufficient, and TEWL values increase, and skin barrier is repaired after supplementing ceramide, and TEWL values reduce.

There is a major class natural biological macromolecular that there is water-wet behavior, Free water can be incorporated in the three-dimensional netted knot that it is formed In structure, Free water is made to become to be not easy Evapotranspiration mistake in conjunction with water.Hyaluronic acid widely exists in the connective tissue of organism, With fabulous moisture-keeping function, it is known as ideal natural moisturizing factor in the world；Polyglutamic acid sodium, poly (sodium aspartate) are new It was found that natural moisture preserving agent, be native biopolymer polypeptide protein, have good biocompatibility, degradable, water absorbing capacity Power, due to containing a large amount of free carboxies in molecule, has larger hydrophily, can improve skin by force and the features such as nontoxic edibility The moisturizing power of skin deep layer, and the water balance inside and outside skin will not be destroyed.

Emollient can fill the gap between spongiocyte, so as to improve skin quality, increase the softness and smooth degree of skin, White pond flower seed oil, castor oil, jojoba seed oil, Queensland nut seed oil, wheat-germ oil, shea butter etc. are more normal for moisturizer Vegetative grease does not stimulate mildly, and stability is high, has effects that moist moisturizing, tightening skin, softening fat.

The mechanism of action of hygroscopic agent is to absorb moisture from corium and external environment, is stored in cuticula.Pyrrolidones Carboxylic acid sodium is the main component of natural moisturizing factor in cuticula, and hygroscopicity is strong far beyond panthenol, sorbierite etc., and with long-term Moisture retention；Allantoin can directly act on keratin, the property with unique keratin-dissolving, increase and promote cuticula hydration energy Power；Trehalose, tremella polysaccharides, avenabeta glucosan are a kind of novel polysaccharide moisturizer, have long-term efficient moisture-retention performance, give The feeling of skin emolliency.

Although moisturizing active constituent type is various, conventional moisturizing creme still has many problems.Keratoderma point The endogenous lipid for exogenous lipid and the sebaceous gland lipid secretion secreted is oily matter, and therefore, liposoluble substance is than water-soluble Property substance skin degree of absorption it is high, water-soluble active ingredient skin permeability is poor.And moisturizing active component is mostly water solubility, Lead to conventional water soluble moisturizing class skin care item utilization rate very little.Secondly, ceramide can strengthen skin barrier function, but it is height Crystal material, solubility is low, water dispersible is poor, and easily crystallization is precipitated in placement process, commercially available ceramide State of cosmetics Mostly common creme, active constituent additive amount is low, skin permeability is poor, hold-up is low.

In order to which the application and skin that solve the problems, such as skin care item active constituent absorb, modern age, some chemists were by medicine and pharmacology one A little theoretical and experiment leads the carrier system sustained release theory and embedding techniques that are initially applied to medicine and pharmacology applied to personal care articles Domain, the effect of property, the stability for improving product, extension shelf life, improvement product appearance to enhance product.Nano-carrier develops It is very fast, good application is obtained in the multiple fields of cosmetics, market prospects are boundless.

Be presently used for moisturizing nanometer package carrier report it is less, and mostly effect it is single, the present invention by moisturizing mechanism not With active material such as physiological lipid, the large biological molecule combined with water, emollient, hygroscopic agent, liquid fat etc. contain in In same nano-composition carrier, realize multiple target point multimachine moisturizing active constituent transdermal total conveying, be effectively increased activity at Transit dose point in skin and hold-up, and can be sustained in skin and controlled release, reach collaboration, long-acting moisture-keeping efficacy, and energy Skin barrier is repaired, skin barrier function is enhanced.The moisturizing conveys that nano-composition Transdermal absorption is good, and the residence time is long altogether, peace Quan Xinggao, drugloading rate is high, is easily added in cosmetic base.At present do not have also with physiological lipid, emollient, hygroscopic agent, The four class moisturizer of large biological molecule combined with water is that the composite Nano composition product of effective moisturizing active constituent is reported.

Invention content

The purpose of the present invention is to provide a kind of moisturizings to convey nano-composition and preparation method thereof altogether, and the composition will protect The different a variety of active ingredients of wet mechanism contains in same nano-carrier, realizes the saturating of multiple target point multimachine moisturizing active constituent Skin conveys, cooperates with moisture-keeping function altogether, has both skin moisture-keeping, stratum corneum barrier repairs double effects.

In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：

The present invention provides a kind of moisturizings to convey nano-composition altogether, includes the component of following mass percentage：0.1% ~10% physiological lipid, 0.2%~10% emollient, 0.5%~25% hygroscopic agent, 0.1%~6% biology combined with water Macromolecular, 1%~20% liquid fat, 10%~50% emulsifier, 5%~30% assistant for emulsifying agent, 0.01%~1% preservative With the water of surplus.

Preferably, the physiological lipid is Cer EOS type, Cer NS type, Cer NP type, Cer NP A One or more of type, Cer NP Type B and Cer AP type；The emollient be white pond flower seed oil, castor oil, flash One or more of bar seed oil, Queensland nut seed oil, wheat-germ oil and shea butter；The hygroscopic agent is pyrrolidones carboxylic One or more of sour sodium, panthenol, sorbierite, allantoin, trehalose, tremella polysaccharides and avenabeta glucosan；Described and water In conjunction with large biological molecule be hyaluronic acid, polyglutamic acid sodium or poly (sodium aspartate).

Preferably, the liquid fat is Miglyol 812N, isopropyl myristate, medium chain triglyceride, palm fibre Palmitic acid isopropyl propionate, Gelucire 44/14, polyethylene glycol tristerin, two pungent capric acid propylene glycol esters, linoleic acid Glyceride, Labraso, diethyl sebacate, isononyl isononanoate, Sefsol 218, triacetic acid One or more of glyceride and squalene.

Preferably, the emulsifier is polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxy Ethylene castor oil, Crodaret, polyoxyethylene fatty acid ester, fatty alcohol polyoxyethylene ether, sorbierite lauric acid One or more of ester, ceteareth and cocoyl glucoside.

Preferably, the assistant for emulsifying agent is that diethylene glycol monoethyl ether, ethoxydiglycol oleate, polyglycereol -6 are different One or more of stearate, octyl dodecanol, propylene glycol, dipropylene glycol, glycerine and 1,3 butylene glycol.

Preferably, the preservative is hexylene glycol, pentanediol, Phenoxyethanol, Sensiva SC50, paraben esters, chlorobenzene In sweet ether, parahydroxyacet-ophenone, decoyl hydroximic acid, the smooth caprylate of sorb, glycerol caprylate, lauroyl arginine ethyl ester hydrochloric acid It is one or more of.

Preferably, which is characterized in that the grain size that the moisturizing conveys nano-composition altogether is 10nm~500nm.

The moisturizing that the present invention provides a kind of as described in said program conveys the preparation method of nano-composition altogether, including with Lower step：

(1) liquid fat, emulsifier, part assistant for emulsifying agent, physiological lipid and emollient are mixed, stirring is until completely Dissolving, obtains oil phase；

(2) it after the large biological molecule combined with water and surplus assistant for emulsifying agent being mixed dispersion, mixes, stirs with hygroscopic agent and water It mixes up to being completely dissolved, obtains water phase；

(3) preservative is added after mixing the oil phase that step (1) obtains with the water phase that step (2) obtains, carries out shearing breast Change is handled, and obtains micrometre level dispersoid；

(4) micrometre level dispersoid for obtaining step (3) carries out high-pressure homogeneous processing, obtains moisturizing and conveys nanometer combination altogether Object；

The mass percentage ratio of part assistant for emulsifying agent and surplus assistant for emulsifying agent in step 2) is (1% in the step 1) ~20%)：(1%~10%)；

There is no time sequencing restriction between the step (1) and step (2).

Preferably, the temperature that oil phase dissolves in the step (1) is 50 DEG C~75 DEG C；

The temperature of aqueous phase dissolved is 50 DEG C~75 DEG C in the step (2)；

The rotating speed that emulsification pretreatment is handled in the step (3) is 5000rpm~10000rpm；The emulsification pretreatment processing Time is 1min~10min.

The pressure of step (4) the mesohigh homogenization is 200bar~1800bar, and cycle-index is 1~10 time.

The moisturizing that the present invention provides a kind of as described in said program conveys nano-composition in skin moisture-keeping, cutin screen altogether Barrier repairs the application in beautifying health cosmetics, and treats chronic dry dermatoses, idiocrasy and contact skin preparing Application in scorching drug.

Beneficial effects of the present invention：

(1) Nano medication targeting vector preparation technique is applied, by physiological lipid, emollient, hygroscopic agent, is combined with water The moisture-keeping efficacy active constituents of four class different mechanisms of large biological molecule be carried in same nano-composition, realize a variety of moisturizings The transdermal total conveying of the moisturizing active constituent of mechanism multiple target point, and can be sustained in skin and controlled release, solve water soluble ingredient The disadvantages such as Transdermal absorption is poor, skin hold-up is low, and physiological lipid solubility is poor, skin care item additive amount is low, bioavilability is low, Moisturizing active constituent can effectively penetrate skin, and be detained for a long time in skin, reach excellent instant moisturizing and long-acting moisturizing Effect, this external enwergy enhance skin barrier function, improve skin itself hydratability.

(2) it is safe to convey nano-composition altogether for the moisturizing, and mild non-stimulated, drugloading rate is big, and water dispersible is good, is easy to It is added in cosmetic base.

(3) accelerated storage test the result shows that, moisturizing provided by the invention convey altogether nano-composition 4 DEG C, 45 DEG C, 10 After DEG C ultraviolet irradiation (illuminance 4000lux), room temperature respectively place 3 months, character and grain size, particle diameter distribution PDI are not shown The variation of work property, illustrates that nano-composition stability is good.Moisture-keeping efficacy evaluation test the result shows that, nano-composition creme ratio is the same as dense Instant moisturizing and the long-acting moistening effect for spending the common creme of active constituent are good, after 4 weeks, use the skin of nano-composition creme Sample TEWL is substantially reduced, and illustrates that moisturizing conveys that nano-composition functional component Transdermal absorption is good altogether, has excellent instant guarantor Wet, long-acting moisturizing, skin barrier repair effect.Skin irritation test is the result shows that moisturizing provided by the invention conveys nanometer altogether Composition is mildly nonirritant to skin.

Description of the drawings

Fig. 1 is that the moisturizing that the embodiment of the present invention 15 obtains conveys the compound creme of nano-composition and with concentration active constituent altogether Common creme is changed using rear moisture content of skin for 24 hours；

Fig. 2 is that the moisturizing that the embodiment of the present invention 15 obtains conveys the compound creme of nano-composition and with concentration active constituent altogether Common creme uses the reduction rate of 4 weeks percutaneous water loss TEWL；

Fig. 3 is that the moisturizing that the embodiment of the present invention 15 obtains conveys the compound creme of nano-composition and with concentration active constituent altogether Common creme uses 4 weeks skin change of moisture content.

Specific implementation mode

In the present invention, the mass percentage of physiological lipid is preferably 0.5%~8% in the composition, more preferably It is 1%~6%；The physiological lipid is preferably Cer EOS type, Cer NS type, Cer NP type, Cer NP A One or more of type, Cer NP Type B and Cer AP type；More preferably Cer NS type, Cer NP type, god Through one or more of amide 3B types and Cer AP type；The physiological lipid is preferably 1~2 kind, when a kind of selection When physiological lipid, more preferably Cer NS type or Cer AP type, when selecting 2 kinds of physiological lipids, more preferably Cer NS type and Cer NP type.In the present invention, the mass percentage ratio of each ingredient in physiological lipid is not limited System.

In the present invention, the mass percentage of emollient is preferably 0.5%~8% in the composition, more preferably 1%~6%；The emollient is preferably white pond flower seed oil, castor oil, jojoba seed oil, Queensland nut seed oil, wheat-germ oil One or more of with shea butter；More preferably white pond flower seed oil, jojoba seed oil, Queensland nut seed oil and wheat embryo One or more of oil；The emollient is preferably 1~2 kind, when selecting a kind of emollient, more preferably Bai Chihua seeds Oil or jojoba seed oil, when selecting 2 kinds of emollients, more preferably jojoba seed oil and wheat-germ oil.In the present invention, to profit There is no limit for the mass percentage ratio of each ingredient in skin agent.

In the present invention, the mass percentage of hygroscopic agent is preferably 2%~20% in the composition, more preferably 5%~15%；The hygroscopic agent be preferably pyrrolidone sodium carboxylate, panthenol, sorbierite, allantoin, trehalose, tremella polysaccharides and One or more of avenabeta glucosan；More preferably pyrrolidone sodium carboxylate, allantoin, trehalose, tremella polysaccharides and swallow One or more of wheat beta glucan；The hygroscopic agent is preferably 1~2 kind, when selecting a kind of hygroscopic agent, more preferably Pyrrolidone sodium carboxylate, trehalose or tremella polysaccharides, when selecting 2 kinds of hygroscopic agents, more preferably allantoin and oat β-Portugal are poly- Sugar.In the present invention, to the mass percentage ratio of each ingredient in hygroscopic agent there is no limit.

In the present invention, the mass percentage of the large biological molecule combined with water is preferably 0.5%~4.0%, More preferably 1.0%~3.0%；The large biological molecule combined with water is preferably hyaluronic acid, polyglutamic acid sodium or poly- day Winter propylhomoserin sodium.

In the present invention, it includes the fluid oil that mass percentage is 1%~20% that the moisturizing conveys nano-composition altogether Fat, preferably 2%~18%, more preferably 3%~15%.In the present invention, the liquid fat is preferably that caprylic capric is sweet Oily three esters, isopropyl myristate, medium chain triglyceride, isopropyl palmitate, Gelucire 44/14, polyethylene glycol Tristerin, two pungent capric acid propylene glycol esters, glyceryl linoleate, Labraso, decanedioic acid diethyl One or more of ester, isononyl isononanoate, Sefsol 218, glyceryl triacetate and squalene；More preferably meat Isopropyl myristate, isopropyl palmitate, Gelucire 44/14, Miglyol 812N, medium chain triglyceride One or more of with isononyl isononanoate；The liquid fat is preferably 1~2 kind, when selecting a kind of liquid fat, More preferably isopropyl myristate, isopropyl palmitate or medium chain triglyceride, when selecting 2 kinds of liquid fats, more preferably For Miglyol 812N and squalene or glyceryl triacetate and isononyl isononanoate.In the present invention, to liquid fat In each ingredient mass percentage ratio there is no limit.

In the present invention, it includes the emulsification that mass percentage is 10%~50% that the moisturizing conveys nano-composition altogether Agent, preferably 15%~40%, more preferably 20%~30%.In the present invention, the emulsifier is preferably that polyoxyethylene loses Water Span, sorbitan fatty acid ester, Emulsifier EL-60, Crodaret, polyoxy second One in alkene aliphatic ester, fatty alcohol polyoxyethylene ether, sorbitan laurate, ceteareth and cocoyl glucoside Kind is several；More preferably polyoxyethylene sorbitan fatty acid ester, Crodaret, polyoxyethylene fatty acid One or more of ester, sorbitan laurate and ceteareth；The emulsifier is preferably 2~3 kinds, works as selection When 2 kinds of emulsifiers, the more preferably mixture of polyoxyethylene sorbitan fatty acid ester and Crodaret, mountain The mixture or Crodaret of pears alcohol laurate and ceteareth and polyoxyethylene fatty acid ester Mixture.In the present invention, to the mass percentage ratio of each ingredient in emulsifier, there is no limit.

In the present invention, it include mass percentage is 5%~30% to help emulsification that the moisturizing conveys nano-composition altogether Agent, preferably 10%~25%, more preferably 15%~20%.In the present invention, the assistant for emulsifying agent is preferably diethylene glycol Single ethylether, ethoxydiglycol oleate, -6 isostearate of polyglycereol, octyl dodecanol, propylene glycol, dipropylene glycol, One or more of glycerine and 1,3 butylene glycol；More preferably diethylene glycol monoethyl ether, -6 isostearate of polyglycereol, pungent One or more of base lauryl alcohol, propylene glycol, dipropylene glycol, glycerine and 1,3 butylene glycol；The assistant for emulsifying agent is preferably 3~ 4 kinds, when selecting 3 kinds of assistant for emulsifying agents, more preferably diethylene glycol monoethyl ether and octyl dodecanol and propylene glycol, 1,3- fourths Glycol and diethylene glycol monoethyl ether and glycerine, dipropylene glycol and -6 isostearate of polyglycereol and 1,3 butylene glycol. In the present invention, to the mass percentage ratio of each ingredient in assistant for emulsifying agent there is no limit.

In the present invention, the moisturizing convey altogether nano-composition include mass percentage be 0.01%~1% preservative, Preferably 0.05%~0.8%, more preferably 0.1%~0.5%.In the present invention, the preservative is preferably hexylene glycol, penta Glycol, Phenoxyethanol, Sensiva SC50, paraben esters, Chlorphenesin, parahydroxyacet-ophenone, decoyl hydroximic acid, sorb are smooth pungent One or more of acid esters, glycerol caprylate and lauroyl arginine ethyl ester hydrochloric acid；More preferably hexylene glycol, pentanediol, benzene Oxyethanol, Sensiva SC50, paraben esters, parahydroxyacet-ophenone, decoyl hydroximic acid and one kind in the smooth caprylate of sorb or It is several；The preservative is preferably 1~2 kind, when selecting 2 kinds of preservatives, more preferably hexylene glycol and parahydroxyacet-ophenone, Pentanediol and decoyl hydroximic acid, Phenoxyethanol and Sensiva SC50 and hexylene glycol and the smooth caprylate of sorb.In the present invention, To the mass percentage ratio of each ingredient in preservative there is no limit.

Moisturizing provided by the invention conveys the water that nano-composition includes surplus altogether, and the water is preferably purified water.

Moisturizing provided by the invention conveys the grain size of nano-composition for 10~500nm, preferably 15~300nm, more altogether Preferably 20~200nm.

The present invention provides the preparation methods that the moisturizing described in said program conveys nano-composition altogether, including walk as follows Suddenly：

In the present invention, liquid fat, emulsifier, part assistant for emulsifying agent, physiological lipid, emollient are mixed, stirring Until being completely dissolved, oil phase is obtained；The temperature of the dissolving is preferably 50 DEG C~75 DEG C, more preferably 55 DEG C~70 DEG C；It is described The time of dissolving is preferably 10~30min, more preferably 11~20min.In the present invention, use of water is preferred for the course of dissolution Bath dissolves by heating.

In the present invention, the large biological molecule combined with water and surplus assistant for emulsifying agent are mixed after being uniformly dispersed, with moisture absorption Agent, water mixing, stirring obtain water phase up to being completely dissolved；The solution temperature is preferably 50 DEG C~75 DEG C, more preferably 55 DEG C~70 DEG C；The time of the dissolving is preferably 10~30min, more preferably 10~20min.In the present invention, the dissolving It is preferable to use water-bath heating for dissolving for process.

In the present invention, the mass percentage ratio of the part assistant for emulsifying agent and surplus assistant for emulsifying agent be (1%~ 20%)：(1%~10%), preferably (5%~15%)：(1%~5%).

In the present invention, preservative is added after obtained oil phase being mixed with obtained water phase, carries out emulsification pretreatment processing, Obtain micrometre level dispersoid；The oil phase and the mixing temperature of water phase are preferably 50 DEG C~75 DEG C, more preferably 55 DEG C~70 DEG C. The rotating speed of the emulsification pretreatment processing is preferably 5000rpm~10000rpm, more preferably 6000rpm~9000rpm, most preferably For 7000rpm~8000rpm；The time of the emulsification pretreatment processing is preferably 1min~10min, and more preferably 3min~ 9min, most preferably 5min~7min.

Mixed in the present invention, it is preferred to which oil phase is added drop-wise in water phase, the speed of the dropwise addition be preferably 1~5 drop/ Second, more preferably 2~3 drops/sec, the present invention is preferably added dropwise under agitation, and the rate of the stirring is preferably 500r/ Min~800r/min, more preferably 600r/min~700r/min.

In the present invention, after obtaining micrometre level dispersoid, high-pressure homogeneous processing is carried out to get moisturizing to micrometre level dispersoid Nano-composition is conveyed altogether；The pressure of the high-pressure homogeneous processing is preferably 200bar~1800bar, and more preferably 400bar~ 1400bar, most preferably 600bar~1200bar；The cycle-index of the high-pressure homogeneous processing is preferably 1~10 time, more excellent It is selected as 2~8 times, most preferably 3~6 times；The temperature of the high-pressure homogeneous processing is preferably 50 DEG C~75 DEG C, more preferably 55 DEG C ~70 DEG C.

In the present invention, the high-pressure homogeneous processing is it is also an option that high-speed micro-jet processing；At the high-speed micro-jet The pressure of reason is preferably 10000~15000psi, more preferably 11000~13000psi；The high-speed micro-jet processing follows Ring number is preferably 1~10 time, more preferably 2~6 times.

In the present invention, the preparation process of the oil phase and water phase does not have the limitation of time sequencing.

Nano-composition is conveyed altogether the present invention provides a kind of moisturizing repairs beauty and health care in skin moisture-keeping, stratum corneum barrier Application in cosmetic, and preparing the application in treating chronic dry dermatoses, idiocrasy and contact dermatitis drug.

Moisturizing provided by the invention convey altogether nano-composition be added in cosmetics can play adjust skin barrier work( Can, improve moisture content of skin the purpose of, and be total to conveying nano-composition in active constituent can effectively penetrate skin surface and Epidermis middle and high concentration is enriched with and is detained for a long time, realizes the conveying of skin multiple target point, the sustained release of nano-composition moisturizing active constituent And controlled release.Moisturizing provided by the invention convey altogether mass percentage of the nano-composition in cosmetics be preferably 1%~ 30%, more preferably 5%~20%.

Moisturizing provided by the invention conveys nano-composition to chronic dry dermatoses, idiocrasy and contact dermatitis altogether There is auxiliary treatment, drug effect can be improved applied to external medicine preparation.Heretofore described chronic dry dermatoses Including psoriasis and ichthyosis.

Moisturizing provided by the invention conveys nano-composition in treating chronic drying property external use medicine for treating dermatosis object preparation altogether Mass percentage be preferably 1%~40%, more preferably 5%~30%.

Nano-composition is conveyed altogether with reference to embodiment to moisturizing provided by the invention to be described in detail, but not They can be interpreted as limiting the scope of the present invention.

Embodiment 1

By 15.0% Gelucire 44/14,20.0% fatty alcohol polyoxyethylene ether, 20.0% cocoyl glucose Glycosides, 2.0% octyl dodecanol, 8.0% Cer NP Type B, 0.2% wheat-germ oil are stirred in the case where temperature is 70 DEG C of water bath conditions Dissolving is mixed, oil phase is obtained, it is spare；

3.0% hyaluronic acid is added in 3.0%1,3- butanediols, it is made to be uniformly dispersed, 6.0% allantoin of addition, 22.8% water, the stirring and dissolving in the case where temperature is 70 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 70 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.05% pentanediol and 0.05% decoyl hydroximic acid is added, High speed shearing emulsification 9min under the conditions of 7000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 800bar, recycles 6 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 100.5nm that can obtain the nano-composition grain size.

Embodiment 2

By 5.0% isopropyl palmitate, 10.0% sorbitan laurate, 5.0% ceteareth, 5.0% 2 Ethylene glycol monomethyl ether, 10.0% glycerine, 0.5% Cer NS type, 2.0% castor oil are in the case where temperature is 55 DEG C of water bath conditions Stirring and dissolving obtains oil phase, spare；

6.0% hyaluronic acid is added in 10.0%1,3- butanediols, it is made to be uniformly dispersed, 2.0% panthenol, 44.5% is added Water, the stirring and dissolving in the case where temperature is 55 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 55 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.5% hexylene glycol and the smooth caprylate of 0.5% sorb is added, High speed shearing emulsification 3min under the conditions of 6000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1800bar, recycles 2 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 15.0nm that can obtain the nano-composition grain size.

Embodiment 3

By 2.0% Miglyol 812N, 10.0% Crodaret, 10.0% polyoxyethylene fatty acid Ester, -6 isostearate of 5.0% polyglycereol, 1.0% Cer NP type, 5.0% jojoba seed oil are 60 DEG C of water-bath items in temperature Stirring and dissolving under part obtains oil phase, spare；

4.0% poly (sodium aspartate) is added in 5.0% dipropylene glycol, 5.0%1,3- butanediols, so that it is uniformly dispersed, adds Enter 0.5% sorbierite, 52.5% water, the stirring and dissolving in the case where temperature is 60 DEG C of water bath conditions obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 60 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 800rpm during adding, and after the completion of mixing, 0.05% paraben esters are added, high under the conditions of 5000rpm Fast emulsification pretreatment 10min, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 200bar, recycles 10 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 300.0nm that can obtain the nano-composition grain size.

Embodiment 4

By 3.0% medium chain triglyceride, 20.0% sorbitan fatty acid ester, 30.0% Emulsifier EL-60, 5.0% ethoxydiglycol oleate, 1.5% Cer NP A types, 6.0% Queensland nut seed oil are 65 DEG C of water-baths in temperature Under the conditions of stirring and dissolving, obtain oil phase, it is spare；

2.0% polyglutamic acid sodium is added in 5.0% propylene glycol, it is made to be uniformly dispersed, 5.0% trehalose, 22.5% is added Water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 4 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 700rpm during adding, and after the completion of mixing, 0.4% hexylene glycol and 0.4% parahydroxyacet-ophenone is added, High speed shearing emulsification 5min under the conditions of 9000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 400bar, recycles 8 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 10.0nm that can obtain the nano-composition grain size.

Embodiment 5

By 11.5% glyceryl triacetate, 7.5% isononyl isononanoate, 8.0% sorbitan fatty acid ester, 12.0% Crodaret, 10.0% diethylene glycol monoethyl ether, 8.0% glycerine, 4.5% Cer NP Type B, 6.0% Australia Continent nut seed oil stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtains oil phase, spare；

2.0% hyaluronic acid is added in 8.0%1,3- butanediols, it is made to be uniformly dispersed, 0.8% sorbierite, 5.0% is added Trehalose, 16.7% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.7% Chlorphenesin is added, high speed under the conditions of 6000rpm Emulsification pretreatment 9min, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1000bar, recycles 3 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 120.5nm that can obtain the nano-composition grain size.

Embodiment 6

By 18.0% polyethylene glycol tristerin, 20.0% polyoxyethylene sorbitan fatty acid ester, 10.0% Sorbitan laurate, 10.0% diethylene glycol monoethyl ether, 6.0% Cer AP type, 0.5% shea butter are in temperature Stirring and dissolving under 75 DEG C of water bath conditions, obtains oil phase, spare；

0.2% polyglutamic acid sodium is added in 10.0% dipropylene glycol, it is made to be uniformly dispersed, 15.0% tremella polysaccharides of addition, 10.3% water, the stirring and dissolving in the case where temperature is 75 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 75 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.45% Phenoxyethanol is added and 0.05% ethylhexyl is sweet Oil, high speed shearing emulsification 7min, is made micrometre level dispersoid under the conditions of 8000rpm；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1200bar, recycles 1 time, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 200.0nm that can obtain the nano-composition grain size.

Embodiment 7

By 20.0% glyceryl linoleate, 10.0% polyoxyethylene fatty acid ester, 5.0% ceteareth, 8.0% - 6 isostearate of polyglycereol, 5.0% Cer NS type, 5.0% Cer NP type, 1.0% jojoba seed oil are in temperature Stirring and dissolving under 70 DEG C of water bath conditions, obtains oil phase, spare；

0.1% polyglutamic acid sodium is added in 5.0% propylene glycol, it is made to be uniformly dispersed, 20.0% avenabeta glucosan of addition, 20.9% water, the stirring and dissolving in the case where temperature is 70 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 70 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 800rpm during adding, and after the completion of mixing, 0.3% glycerol caprylate and 0.3% pentanediol is added, High speed shearing emulsification 6min under the conditions of 7000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1000bar, recycles 5 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 500.0nm that can obtain the nano-composition grain size.

Embodiment 8

By 8.0% Sefsol 218,10.0% sorbitan fatty acid ester, 5.0% polyoxyethylene fatty acid ester, 5.0% ethoxydiglycol oleate, 2.0% Cer NS type, 1.0% shea butter are 65 DEG C of water bath conditions in temperature Lower stirring and dissolving, obtains oil phase, spare；

0.5% poly (sodium aspartate) is added in 5.0% propylene glycol, it is made to be uniformly dispersed, 5.0% allantoin, 2.0% is added Trehalose, 56.5% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 500rpm during adding, and after the completion of mixing, 0.5% lauroyl arginine ethyl ester hydrochloric acid is added, High speed shearing emulsification 5min under the conditions of 8000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 900bar, recycles 4 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 60.8nm that can obtain the nano-composition grain size.

Embodiment 9

By 6.8% glyceryl triacetate, 6.0% isononyl isononanoate, 12.0% fatty alcohol polyoxyethylene ether, 8.0% whale Wax stereth, 5.0% ethoxydiglycol oleate, 5.0% octyl dodecanol, 2.5% Cer NP type, 4.5% Shea butter, 1.0% the wheat-germ oil stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain oil phase, spare；

1.5% polyglutamic acid sodium is added in 5.0% propylene glycol, it is made to be uniformly dispersed, 0.5% 2-pyrrolidone-5-carboxylic acid is added Sodium, 12.0% trehalose, 30.2% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 700rpm during adding, and after the completion of mixing, 0.5% hexylene glycol and 0.5% decoyl hydroximic acid is added, High speed shearing emulsification 6min under the conditions of 8000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 600bar, recycles 4 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 300.8nm that can obtain the nano-composition grain size.

Embodiment 10

By 6.0% diethyl sebacate, 8.0% polyoxyethylene sorbitan fatty acid ester, 15.0% sorbierite bay Acid esters, 10.0% octyl dodecanol, 1.5% Cer NP type, 2.0% jojoba seed oil are in the case where temperature is 65 DEG C of water bath conditions Stirring and dissolving obtains oil phase, spare；

0.5% polyglutamic acid sodium is added in 5.0% propylene glycol, it is made to be uniformly dispersed, 1.0% 2-pyrrolidone-5-carboxylic acid is added Sodium, 10.0% trehalose, 41.0% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.3% pentanediol and 0.3% decoyl hydroximic acid is added, High speed shearing emulsification 5min under the conditions of 9000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1100bar, recycles 4 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 72.3nm that can obtain the nano-composition grain size.

Embodiment 11

By 7.5% Labraso, 15.0% sorbitan fatty acid ester, 15.0% polyoxyethylene Rilanit special, 8.0% diethylene glycol monoethyl ether, 2.0% Cer NP Type B, 3.0% wheat-germ oil are 65 in temperature Stirring and dissolving under DEG C water bath condition, obtains oil phase, spare；

1.5% polyglutamic acid sodium is added in 10.0%1,3- butanediols, it is made to be uniformly dispersed, 15.0% trehalose of addition, 23.0% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.3% pentanediol and the smooth caprylate of 0.5% sorb is added, High speed shearing emulsification 6min under the conditions of 7000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 600bar, recycles 3 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 64.5nm that can obtain the nano-composition grain size.

Embodiment 12

By 12.0% isononyl isononanoate, 15.5% Emulsifier EL-60,15.5% ceteareth, 10.0% Diethylene glycol monoethyl ether, 5.0% Cer AP type, 4.0% Queensland nut seed oil are stirred in the case where temperature is 65 DEG C of water bath conditions Dissolving, obtains oil phase, spare；

2.0% hyaluronic acid is added in 5.0% dipropylene glycol, it is made to be uniformly dispersed, 7.0% tremella polysaccharides of addition, 24.0% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtains water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 500rpm during adding, and after the completion of mixing, 0.4% Phenoxyethanol and 0.4% Sensiva SC50 is added, High speed shearing emulsification 8min, is made micrometre level dispersoid under the conditions of 8000rpm；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1300bar, recycles 5 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 50.2nm that can obtain the nano-composition grain size.

Embodiment 13

By 13.8% glyceryl triacetate, 8.0% Emulsifier EL-60,15.0% sorbitan laurate, 8.0% second Oxygroup diethylene glycol oleate, 4.0% Cer NP A types, 6.0% jojoba seed oil are stirred in the case where temperature is 60 DEG C of water bath conditions Dissolving is mixed, oil phase is obtained, it is spare；

2.5% polyglutamic acid sodium is added in 6.5% propylene glycol, it is made to be uniformly dispersed, 0.8% allantoin, 7.5% swallow is added Wheat beta glucan, 27.9% water, the stirring and dissolving in the case where temperature is 60 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 60 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.4% hexylene glycol and the smooth caprylate of 0.4% sorb is added, High speed shearing emulsification 5min under the conditions of 9000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 800bar, recycles 3 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 75.5nm that can obtain the nano-composition grain size.

Embodiment 14

8.6% squalene, 12.0% Crodaret, 18.0% cocoyl glucoside, 12.0% are gathered sweet Oily -6 isostearates, 3.5% Cer NS type, 3.5% jojoba seed oil, 2.0% white pond flower seed oil are 60 DEG C of water in temperature Stirring and dissolving under the conditions of bath obtains oil phase, spare；

1.8% poly (sodium aspartate) is added in 10.0%1,3- butanediols, it is made to be uniformly dispersed, 15.0% pyrrolidines is added Keto carboxylic acid sodium, 13.6% water, the stirring and dissolving in the case where temperature is 60 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 60 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 650rpm during adding, and after the completion of mixing, 0.6% glycerol caprylate is added, high under the conditions of 8000rpm Fast emulsification pretreatment 5min, is made micrometre level dispersoid；

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 48.8nm that can obtain the nano-composition grain size.

Embodiment 15

By 8.5% Miglyol 812N, 5.0% squalene, 15.0% polyoxyethylene sorbitan fatty acid ester, 10.0% polyoxyethylene fatty acid ester, 12.0% octyl dodecanol, 5.5% Cer AP type, 3.5% jojoba seed oil are in temperature Degree is stirring and dissolving under 60 DEG C of water bath conditions, obtains oil phase, spare；

2.8% polyglutamic acid sodium is added in 5.0% propylene glycol, it is made to be uniformly dispersed, 0.8% allantoin, 5.5% general is added Alcohol, 26.4% water, the stirring and dissolving in the case where temperature is 60 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 3 drops/sec of speed in water phase under 60 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.6% lauroyl arginine ethyl ester hydrochloric acid is added, High speed shearing emulsification 5min under the conditions of 8000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 700bar, recycles 5 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 150.8nm that can obtain the nano-composition grain size.

Embodiment 16

By 15.0% isopropyl myristate, 12.0% cocoyl glucoside, 12.0% Crodaret, 15.0% glycerine, 3.5% Cer NS type, 3.8% the castor oil stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain oil Phase, it is spare；

1.5% polyglutamic acid sodium is added in 8.0% dipropylene glycol, it is made to be uniformly dispersed, 1.0% allantoin, 6.0% is added Trehalose, 22.2% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 650rpm during adding, and after the completion of mixing, 0.6% paraben esters are added, high speed under the conditions of 7000rpm Emulsification pretreatment 8min, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 900bar, recycles 6 times, obtains moisturizing Nano-composition is conveyed altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 220.8nm that can obtain the nano-composition grain size.

Embodiment 17

By 1.0% isopropyl myristate, 5.0% polyoxyethylene sorbitan fatty acid ester, 5.0% polyoxyethylene hydrogen Change castor oil, 10.0% diethylene glycol monoethyl ether, 10.0% octyl dodecanol, 0.1% Cer EOS type, 10.0% white pond Flower seed oil stirring and dissolving in the case where temperature is 50 DEG C of water bath conditions, obtains oil phase, spare；

1.0% polyglutamic acid sodium is added in 10.0% propylene glycol, it is made to be uniformly dispersed, 25.0% 2-pyrrolidone-5-carboxylic acid is added Sodium, 22.9% water, the stirring and dissolving in the case where temperature is 50 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 1 drop/sec of speed in water phase under 50 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 500rpm during adding, and after the completion of mixing, 0.01% Chlorphenesin is added, high under the conditions of 10000rpm Fast emulsification pretreatment 1min, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 1400bar, recycles 3 times, is protected It is wet to convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 20.0nm that can obtain the nano-composition grain size.

Embodiment 18

By 7.5% 2 pungent capric acid propylene glycol ester, 8.0% fatty alcohol polyoxyethylene ether, 10.0% cocoyl glucoside, 10.0% glycerine, 0.5% Cer AP type, 6.0% jojoba seed oil, 2.0% wheat-germ oil are 65 DEG C of water-bath items in temperature Stirring and dissolving under part obtains oil phase, spare；

0.5% polyglutamic acid sodium is added in 10.0%1,3- butanediols, it is made to be uniformly dispersed, 2.5% allantoin of addition, 2.0% avenabeta glucosan, 41.0% water, the stirring and dissolving in the case where temperature is 65 DEG C of water bath conditions, obtain water phase, spare；

After obtaining oil phase and water phase, oil phase is added dropwise to 2 drops/sec of speed in water phase under 65 DEG C of water bath conditions, is dripped Control stir speed (S.S.) is 600rpm during adding, and after the completion of mixing, 0.4% hexylene glycol and 0.4% parahydroxyacet-ophenone is added, High speed shearing emulsification 6min under the conditions of 7000rpm, is made micrometre level dispersoid；

Micrometre level dispersoid is subjected to high-pressure homogeneous processing under conditions of pressure is 800bar, recycles 4 times, obtains moisturizing Nano-composition is conveyed altogether.Herein, moisturizing can be equally obtained using high-speed micro-jet technology convey nano-composition altogether.

The grain size for conveying nano-composition altogether to moisturizing is detected, and it is 85.5nm that can obtain the nano-composition grain size.

Embodiment 19

Moisturizing obtained by embodiment 15~18 is conveyed nano-composition altogether to be placed in closed container, room temperature, 4 DEG C, 45 DEG C, respectively place 3 months under the conditions of 10 DEG C of ultraviolet irradiations (illuminance 4000lux), check sample in the front and back each condition of storage Under character, grain size of test sample under the conditions of storage is front and back each, sample is diluted with purified water when test, and mass fraction is 10%, experimental result is as shown in table 1.

1 embodiment of table, 15~18 moisturizing conveys nano-composition stability test result altogether

Stability test the result shows that：Moisturizing provided by the invention conveys nano-composition soilless sticking, lamination, grain altogether Diameter meets application request between 10nm~500nm.Sample is in room temperature, 4 DEG C, 45 DEG C, 10 DEG C of ultraviolet irradiation (illumination Degree 4000lux) under the conditions of respectively place 3 months after do not occur reunion lamination yet, and conspicuousness variation does not occur for grain size, still So meet practical application request, especially still relatively stablize in the case of activity component concentration height, does not find crystallization precipitation phenomenon, Active substance leaks, and therefore, it is with good stability that moisturizing provided by the invention conveys nano-composition altogether.

Comparative example 1

Common moisturiser is prepared according to conventional creme preparation method：By 0.55% Cer AP, 0.35% Jojoba seed Oil, 6.0% Miglyol 812N, 3.0% cetostearyl alcohol, 2.0% stereth -2,2.0% stereth - 21,1.0% glycerin monostearate heats melting in 75 DEG C of water-baths, obtains oil phase；By 0.28% polyglutamic acid sodium, 0.08% Allantoin, 0.55% panthenol, 5.0% glycerine, 5.0% propylene glycol, 0.15% carbomer and 73.39% purified water are in 75 DEG C of water-baths Middle dissolving, obtains water phase；Oil phase is added dropwise to water phase to be stirred, 3min is emulsified in 10000rpm rotating speed down cuts, is added 0.15% triethanolamine continues to shear 2min, cooling, and 0.5% Phenoxyethanol is added, and it is 0.55% to stir evenly to get content Cer AP, 0.35% jojoba seed oil, 0.28% polyglutamic acid sodium, 0.08% allantoin, the common creme of 0.55% panthenol.

Comparative example 2

It is consistent described in specific method and above-mentioned technical proposal by the formula and method preparation blank creme in comparative example 1, This is repeated no more.

Comparative example 3

Blank creme in comparative example 2 is conveyed into nano-composition according to quality percentage altogether with moisturizing prepared by embodiment 15 Content is than 9:1 is compounded, and it is 0.55% Cer AP, 0.35% jojoba seed oil, 0.28% polyglutamic acid to obtain content The compound creme of nano-composition of sodium, 0.08% allantoin, 0.55% panthenol.

Embodiment 20

Moisturizing obtained by embodiment 15~18 is conveyed into nano-composition sample altogether, respectively with the blank in comparative example 2 Creme is according to mass percentage than 3:7 are compounded, and skin irritation test is carried out：

Healthy rabbits 30, weight (2.0 ± 0.2) kg are taken to be randomly divided into 5 groups, every group of animal 6 for 24 hours will before experiment Rabbit skin of back both sides unhairing checks whether skin of unhairing is injured after unhairing for 24 hours, and compromised skin is unfit to do skin irritation examination It tests.The compound creme 3 times that the moisturizing obtained using embodiment 15~18 conveys nano-composition preparation altogether is smeared daily, it is continuous to apply It smears 7 days, while smearing blank creme (not giving any drug) and being compareed, observe test result, test result is listed in table 2 In.

The moisturizing prepared using embodiment 15~18, which is can be seen that, according to the test result in table 2 conveys nanometer combination altogether Compound creme and blank creme prepared by object is applied to after a rabbit skin without congested, red and swollen phenomenon, is illustrated provided by the invention Moisturizing conveys nano-composition altogether does not have irritation to skin.

The creme and blank group skin irritation of 2 embodiment of table, 15~18 sample preparation observe result

"+" rabbit dermohemia, redness；" ++ " indicates that congested, red and swollen phenomenon still exists, but has increase trend；"-" indicates Without congested, red and swollen phenomenon.

Embodiment 21

Take comparative example 1, comparative example 2, common creme, blank creme and the compound creme of nano-composition made from comparative example 3 Skin moisture-keeping efficacy assessments test is carried out, test equipment is the skin moisture content measuring instrument CM825 of CK companies of Germany production.

Choose 25 skin healths, without volunteer between 20~35 years old of cosmetic allergic contact dermatitis history, age as subject, Select the left and right inboard arm of subject away from being experiment position at palm base portion 5cm, test area is 5 × 5cm², smear respectively etc. The comparative example 1 of amount, comparative example 2, common creme, blank creme and the compound creme of nano-composition made from comparative example 3, experiment Before, subject uniformly cleans both hands inner forearm, constant-temperature constant-humidity environment (20 DEG C ± 2 DEG C of temperature, relative humidity 50% ± 10%) sit quietly 30min in, then test subject's test area blank value and using creme 0.5h, 1h, 2h, 4h, 6h, 8h, The water content of skin after for 24 hours, measures parallel determination 5 times, is averaged every time.The result drafting pattern 1 that will be obtained.

Comparative example 1, comparative example 2, common creme, blank creme made from comparative example 3 are can be seen that according to the result in Fig. 1 It is almost the same with the moisturizing trend of the compound creme of nano-composition, but moisturizing conveys the instant guarantor of the compound creme of nano-composition altogether Wet effect and it is long when moistening effect be superior to the common creme of same concentration active constituent, show that moisturizing provided by the invention conveys altogether Active constituent energy fast skin penetration surface layer in nano-composition, and effective concentration can be maintained in the long period, it realizes The skin targeting conveying of skin care activity ingredient.

Embodiment 22

Take comparative example 1, comparative example 2, common creme, blank creme and the compound creme of nano-composition made from comparative example 3 Skin moisture-keeping efficacy assessments test is carried out, test equipment is the skin water loss tester TM300 of CK companies of Germany production.

Choose 25 skin healths, without volunteer between 20~35 years old of cosmetic allergic contact dermatitis history, age as subject, Select the left and right inboard arm of subject away from being experiment position at palm base portion 5cm, test area is 5 × 5cm², before experiment, by Examination person uniformly cleans both hands inner forearm, quiet in constant-temperature constant-humidity environment (20 DEG C ± 2 DEG C of temperature, relative humidity 50% ± 10%) 30min is sat, the blank value of subject's test area is tested.Then phase is smeared in same test zone sooner or later daily within 4 weeks Common creme, blank creme and the compound creme of nano-composition made from the comparative example 1, comparative example 2, comparative example 3 of equivalent are answered, 1st day, 3 days, 5 days, 10 days, 15 days, 20 days, 28 days test skin water loss rates, before test, subject is in constant temperature and humidity Sit quietly 30mim in environment (20 DEG C ± 2 DEG C of temperature, relative humidity 50% ± 10%), measures parallel determination 5 times every time, is averaged Value.The result drafting pattern 2 that will be obtained.

Percutaneous water loss (TEWL) reflects evaporation capacity of the moisture from skin surface, is the important mark of skin barrier function Will.The pathological characteristic of drying property skin is that skin barrier is destroyed, and ceramide amount is insufficient, and TEWL values increase, supplement nerve Skin barrier is repaired after amide, and TEWL values reduce.As shown in Figure 2, nanometer is conveyed altogether in the moisturizing prepared using comparative example 3 After 10 days, percutaneous water loss rate reduces rapidly the compound creme of composition, divides bleed rate to reduce through the severe edema due to hypofunction of the spleen using after 28 days 20%, illustrate that skin barrier is repaired, ceramide measures supplement in skin, shows that moisturizing altogether conveys nanometer combination Ceramide in object can effectively penetrate skin surface and is enriched in skin histology.And common creme effect prepared by comparative example 1 Fruit is only slightly better than blank creme, this is because ceramide is high crystalline substance, solubility is low, the neural acyl in common creme Easily crystallization is precipitated amine in placement process, and skin permeability is poor.The moisturizing of the present invention conveys nano-composition altogether effectively to repair Skin barrier enhances epidermal barrier function.

Embodiment 23

Choose 25 skin healths, without volunteer between 20~35 years old of cosmetic allergic contact dermatitis history, age as subject, Select the left and right inboard arm of subject away from being experiment position at palm base portion 5cm, test area is 5 × 5cm², before experiment, by Examination person uniformly cleans both hands inner forearm, quiet in constant-temperature constant-humidity environment (20 DEG C ± 2 DEG C of temperature, relative humidity 50% ± 10%) 30min is sat, the blank value of subject's test area is tested.Then phase is smeared in same test zone sooner or later daily within 4 weeks Common creme, blank creme and the compound creme of nano-composition made from the comparative example 1, comparative example 2, comparative example 3 of equivalent are answered, 1st day, 3 days, 5 days, 10 days, 15 days, 20 days, 28 days test moisture content of skin, before test, subject is in constant-temperature constant-humidity environment Sit quietly 30mim in (20 DEG C ± 2 DEG C of temperature, relative humidity 50% ± 10%), measures parallel determination 5 times every time, is averaged.It will Obtained result drafting pattern 3.

From the figure 3, it may be seen that moisturizing prepared by comparative example 3 conveys the compound creme of nano-composition and is carried to skin hydration ability altogether Height is substantially better than common creme and blank creme prepared by comparative example 1 and comparative example 2, and after using 28 days, nano-composition is multiple The sample skin water content for closing creme processing improves 40%, and the content of ceramide improves in epidermis, cuticula moisture holding capacity Enhancing, skin restore rapidly moisturizing and barrier function.Show that moisturizing provided by the invention conveys the nerve in nano-composition altogether Amide can effectively penetrate skin surface, and the compound creme transdermal effect of nano-composition is substantially better than common creme, while moisturizing is total Conveying nano-composition can effectively improve skin hydration ability.

As seen from the above embodiment, moisturizing provided by the invention conveys that nano-composition stability is good, drugloading rate is big, skin altogether Skin permeability is good, the residence time is long, mild non-stimulated, and there is excellent instant moisturizing, long-acting moisturizing, skin barrier to repair work( Effect, can improve skin itself hydratability.The moisturizing conveys that nano-composition is safe, and water dispersible is good altogether, is easy to add Into cosmetic base.

The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims

1. a kind of moisturizing conveys nano-composition altogether, include the component of following mass percentage：0.1%~10% physiological fat Matter, 0.2%~10% emollient, 0.5%~25% hygroscopic agent, 0.1%~6% large biological molecule combined with water, 1%~ 20% liquid fat, 10%~50% emulsifier, 5%~30% assistant for emulsifying agent, the water of 0.01%~1% preservative and surplus.

2. moisturizing according to claim 1 conveys nano-composition altogether, which is characterized in that the physiological lipid is nerve One in 1 type of amide, Cer NS type, Cer NP type, Cer NP A types, Cer NP Type B and Cer AP type Kind is several；The emollient is white pond flower seed oil, castor oil, jojoba seed oil, Queensland nut seed oil, wheat-germ oil and breast One or more of wooden fruit oil；The hygroscopic agent is pyrrolidone sodium carboxylate, panthenol, sorbierite, allantoin, trehalose, silver One or more of fungus polysaccharides and avenabeta glucosan；The large biological molecule combined with water is hyaluronic acid, polyglutamic Sour sodium or poly (sodium aspartate).

3. moisturizing according to claim 1 conveys nano-composition altogether, which is characterized in that the liquid fat is the sad last of the ten Heavenly stems Acid glycerol three ester, isopropyl myristate, medium chain triglyceride, isopropyl palmitate, Gelucire 44/14, poly- second Glycol tristerin, two pungent capric acid propylene glycol esters, glyceryl linoleate, Labraso, decanedioic acid One or more of diethylester, isononyl isononanoate, Sefsol 218, glyceryl triacetate and squalene.

4. moisturizing according to claim 1 conveys nano-composition altogether, which is characterized in that the emulsifier is polyoxyethylene Sorbitan fatty acid ester, sorbitan fatty acid ester, Emulsifier EL-60, Crodaret, polyoxy In ethylene aliphatic ester, fatty alcohol polyoxyethylene ether, sorbitan laurate, ceteareth and cocoyl glucoside It is one or more of.

5. moisturizing according to claim 1 conveys nano-composition altogether, which is characterized in that the assistant for emulsifying agent is diethyl two Alcohol list ethylether, ethoxydiglycol oleate, -6 isostearate of polyglycereol, octyl dodecanol, propylene glycol, dipropyl two One or more of alcohol, glycerine and 1,3 butylene glycol.

6. moisturizing according to claim 1 conveys nano-composition altogether, which is characterized in that the preservative be hexylene glycol, Pentanediol, Phenoxyethanol, Sensiva SC50, paraben esters, Chlorphenesin, parahydroxyacet-ophenone, decoyl hydroximic acid, sorb are smooth One or more of caprylate, glycerol caprylate, lauroyl arginine ethyl ester hydrochloric acid.

7. the moisturizing according to claim 1~6 any one conveys nano-composition altogether, which is characterized in that the moisturizing The grain size of conveying nano-composition is 10nm~500nm altogether.

8. the moisturizing described in claim 1~6 any one conveys the preparation method of nano-composition altogether, include the following steps：

(1) liquid fat, emulsifier, part assistant for emulsifying agent, physiological lipid and emollient are mixed, stirring is until completely molten Solution, obtains oil phase；

(2) it after the large biological molecule combined with water and surplus assistant for emulsifying agent being mixed dispersion, is mixed with hygroscopic agent and water, stirring is straight To being completely dissolved, water phase is obtained；

(3) preservative is added after mixing the oil phase that step (1) obtains with the water phase that step (2) obtains, carries out at emulsification pretreatment Reason, obtains micrometre level dispersoid；

(4) micrometre level dispersoid for obtaining step (3) carries out high-pressure homogeneous processing, obtains moisturizing and conveys nano-composition altogether；

In the step 1) in part assistant for emulsifying agent and step 2) the mass percentage ratio of surplus assistant for emulsifying agent be (1%~ 20%)：(1%~10%)；

There is no time sequencing restriction between the step (1) and step (2).

9. preparation method according to claim 8, which is characterized in that the temperature that oil phase dissolves in the step (1) is 50 DEG C~75 DEG C；

The rotating speed that emulsification pretreatment is handled in the step (3) is 5000rpm~10000rpm；The time of the emulsification pretreatment processing For 1min~10min.

10. the moisturizing described in claim 1-7 any one conveys nano-composition or claim 8-9 any one institute altogether The moisturizing that the preparation method stated is prepared conveys application of the nano-composition in beautifying health cosmetics altogether, and is preparing Treat the application in chronic dry dermatoses, idiocrasy and contact dermatitis drug.