CN109806177A - A kind of high-efficiency moisturizing composition - Google Patents

A kind of high-efficiency moisturizing composition Download PDF

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Publication number
CN109806177A
CN109806177A CN201910216766.6A CN201910216766A CN109806177A CN 109806177 A CN109806177 A CN 109806177A CN 201910216766 A CN201910216766 A CN 201910216766A CN 109806177 A CN109806177 A CN 109806177A
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CN
China
Prior art keywords
lipid
moisturizing composition
saualane
efficiency moisturizing
efficiency
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Pending
Application number
CN201910216766.6A
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Chinese (zh)
Inventor
谢静红
严泽民
王天翔
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Huida Biomedicine (suzhou) Co Ltd
Dermaceutical Products Inc
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Huida Biomedicine (suzhou) Co Ltd
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Priority to CN201910216766.6A priority Critical patent/CN109806177A/en
Publication of CN109806177A publication Critical patent/CN109806177A/en
Pending legal-status Critical Current

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Abstract

The invention discloses a kind of high-efficiency moisturizing composition, including saualane, liquid monoesters and lipid, the content of the high-efficiency moisturizing composition each component are as follows: by percentage to the quality, saualane 50-95%, liquid monoesters 3-30%, lipid 0.1-20%.Through the above way, high-efficiency moisturizing composition of the invention, it is a kind of bionical substance of vernix caseosa, its component and ratio are similar with human skin lipid, skin can be helped to rebuild barrier function, transdermal dehydration is reduced, be different from the moisturizings approach such as glycerol, grease, fundamentally realize skin water profit, cosmetics can be further used as, skin nursing, personal nursing, the composition in pharmaceutical formulation carry out using.

Description

A kind of high-efficiency moisturizing composition
Technical field
The present invention relates to household chemicals technical field of compositions, more particularly to a kind of high-efficiency moisturizing composition.
Background technique
Vernix caseosa is a kind of one layer of natural protective film for being covered on fetus an d neonate skin surface, by wax ester, sterol, spiny dogfish The free lipid such as alkene, ceramide, cholesterol, triglycerides and cell component composition.According to known to present people, vernix caseosa is the mankind Exclusive, although other animals have a similar structure, such as the periphery film of rodent, the lanolin of sheep and vernix caseosa have Similar function, but be not reported in these substances containing cell component.The ingredient of vernix caseosa and skin lipid composition at Seemingly, the time that in addition vernix caseosa is formed is gestation last three months for classification, close with the cuticula formation time, therefore, it is considered that using tire Rouge can protect the skin of cuticle loss, accelerate skin barrier reparation.Exactly because the excellent performance of vernix caseosa, therefore, vernix caseosa Bionical substance is very by the market demand.
Summary of the invention
The invention mainly solves the technical problem of providing a kind of high-efficiency moisturizing compositions, can help the function of skin barrier It rebuilds, realizes moisturizing from inside to outside.
In order to solve the above technical problems, one technical scheme adopted by the invention is that: a kind of high-efficiency moisturizing composition is provided, Including saualane, liquid monoesters and lipid, the content of the high-efficiency moisturizing composition each component are as follows: by percentage to the quality, angle Shark alkane 50-95%, liquid monoesters 3-30%, lipid 0.1-20%.
In a preferred embodiment of the present invention, the high-efficiency moisturizing composition is by saualane, liquid monoesters and lipid group At the content of the high-efficiency moisturizing composition each component are as follows: by percentage to the quality, saualane 50-95%, liquid monoesters 3- 30%, lipid 0.1-20%.
In a preferred embodiment of the present invention, the source of the saualane is that animal, plant or fermentation obtain.
In a preferred embodiment of the present invention, the source of the saualane is that fermentation obtains.
In a preferred embodiment of the present invention, the source of the liquid monoesters is the fat for being R- (COOH) n by formula What acid was reacted with alcohol, wherein R is the aryl of the alkyl of C2-C45, C2-C45, and the alkyl is direct-connected or branch saturation Or unsaturated alkyl, the aryl be one or more phenyl with substituent group, the substituent group be linear saturation alkyl, Straight chain unsaturated alkyl, branch saturated alkyl or branch unsaturated alkyl, n are more than or equal to 1, and the alcohol is that the degree of polymerization is 2-8's Alcohols or polyglycereol.
In a preferred embodiment of the present invention, the liquid monoesters are polyglycereol isostearate.
In a preferred embodiment of the present invention, the lipid is fatty acid, glycerolipid, glycerophosphatide class, sphingolipid One of class, sterol lipid, pregnenolone lipid, glycolipid class, poly vinyl or a variety of mixtures.
In a preferred embodiment of the present invention, the lipid be caprylic/capric triglyceride, cholesterol, ceramide, One of lecithin, oleic acid, lanonol or a variety of mixtures.
A kind of bionical substance of vernix caseosa the beneficial effects of the present invention are: high-efficiency moisturizing composition of the invention, component and Ratio is similar with human skin lipid, and skin can be helped to rebuild barrier function, transdermal dehydration is reduced, be different from glycerol, grease etc. Moisturizing approach fundamentally realizes skin water profit, can be further used as cosmetics, skin nursing, personal nursing, in pharmaceutical formulation Composition carry out using.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's all other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.
Embodiment one:
A kind of high-efficiency moisturizing composition is provided, by saualane, jojoba oil, lecithin, cholesterine, ceramideComposition.Institute State the content of high-efficiency moisturizing composition each component are as follows: by percentage to the quality, saualane 70.5%, jojoba oil 20%, lecithin 3%, cholesterine 6%, ceramide 0.5%。
The preparation method of the bionical composition, including step are as follows: (1) saualane, jojoba oil are heated to 95 DEG C; (2) ceramide is added, stirring and dissolving is uniform;(3) lecithin, cholesterine is added, stirring and dissolving is uniform;(4) 40 are cooled to ℃。
Embodiment two:
A kind of high-efficiency moisturizing composition is provided, it is solid by saualane, polyglycereol isostearate, caprylic/capric triglyceride, gallbladder Alcohol, lecithin, ceramide II, glycosyl sphingolipid, cholesterol sulfate composition.The content of the high-efficiency moisturizing composition each component Are as follows: by percentage to the quality, saualane 60.8%, polyglycereol isostearate 20%, caprylic/capric triglyceride 7%, gallbladder are solid Alcohol 6%, lecithin 3%, ceramide II 0.5%, glycosyl sphingolipid 2.4%, cholesterol sulfate 0.3%.
The preparation method of the high-efficiency moisturizing composition, including step are as follows: (1) saualane is heated to 95 DEG C;(2) one by one Rest materials are added, stirring and dissolving is uniform;(3) 40 DEG C are cooled to.
Effect experiment: the permeable dehydration test experiments of skin
Equipment: it is tested using Delfin VapoMeter moisture of skin tester.
Health volunteer 10, the age 20 ~ 30 years old, average out to 26.5 years old.Left arm uses efficient guarantor described in embodiment two Wet composition, right arm use saualane.Region on probation delimited in subject's inboard arm first, initial value is tested, then distinguishes Sample is tried out in this two pieces of regions, skin transdermal dehydration is measured when 28 days on probation, test result see the table below.
Before on probation After 28 days
Embodiment two 9.59 8.72
Saualane 9.60 9.15
The transdermal dehydration of skin all makes moderate progress after the composition and saualane using embodiment two, and embodiment two improves journey It spends bigger than saualane.
Embodiment three:
A kind of moisturizing emulsion is provided, is to obtain high-efficiency moisturizing composition of the present invention in conjunction with other auxiliary materials, specifically Component and content are as follows: by percentage to the quality, water 77.55%, glycerol 6.00%, dipotassium glycyrrhizinate 0.10%, fragrant fresh ketone Symsave H 0.50%, butanediol 3.00%, Hydrolite 6 0.50%, xanthan gum 0.15%, caprylic/capric triglyceride 3.00%, monoglyceride 0.80%, cetostearyl alcohol 1.50%, high-efficiency moisturizing composition 5.00%, stearic acid described in embodiment two 62 Pellets 1.50% of glyceride citrate Axol C, ammonium acryloyldime-thyltaurate/VP copolymer 0.40%.
The preparation method of the moisturizing emulsion, step include: (1) weighed in beaker water, glycerol, dipotassium glycyrrhizinate, Symsave H, butanediol, Hydrolite 6, xanthan gum, are heated with stirring to 85 DEG C;(2) weighed in another beaker octanoic acid/ Triglyceride DDD, monoglyceride, cetostearyl alcohol, 62 Pellets of Axol C, two moisture-keeping composition of embodiment, agitating and heating To 85 DEG C;(3) step 2 material is added in step 1 material under high speed homogenization, acryloyldimethyl ox is added in homogeneous after five minutes Ichthyodin/VP copolymer, again high speed homogenization 5 minutes;(4) stirring is cooled to room temperature.
High-efficiency moisturizing composition of the present invention is the bionical composition of baby's vernix caseosa, and ingredient and cutin are at grouping At similar, by balancing and the lipid of reconstructed skin forms and distribution, skin barrier reparation is helped, and then promote skin itself Moisture-retaining capacity reaches moisturizing purpose.
All content squalene in the skin lipid and organ of human body, this is a kind of ingredient that human body itself can generate, health Content about 12% or so in cuticula, its secretory volume reduces with advancing age, influences skin health.Saualane is squalene Hydrogenated products, and sebum ingredient it is similar it, it is easier to incorporate skin, reduce due to squalene missing that bring skin is asked Topic.
It include saualane, liquid monoesters and lipid in composition of the invention, the saualane in composition can be used as imitative The carrier application of raw composition.Lipid in composition is the lipid of structure same or similar with Stratum corneum lipids, can be faster Broken skin skin is incorporated, the lipid composition of balance and reconstructed skin realizes moisturizing.
Lipid cannot dissolve well in saualane, liquid monoesters need to be used as cosolvent, to acyl neural in saualane Amine, cholesterol, sterol ester, phosphatide etc. have extraordinary solubilization.Experiment discovery polyglycereol isostearate solubilizing effect It is especially surprising.Only three kinds of substances are just able to achieve the effect of efficient moisture-retention to composition of the present invention, moreover it is possible to other substance groups It closes and uses.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks Domain is included within the scope of the present invention.

Claims (8)

1. a kind of high-efficiency moisturizing composition, which is characterized in that including saualane, liquid monoesters and lipid, the efficient moisture-retention group Close the content of object each component are as follows: by percentage to the quality, saualane 50-95%, liquid monoesters 3-30%, lipid 0.1-20%.
2. high-efficiency moisturizing composition according to claim 1, which is characterized in that the high-efficiency moisturizing composition is by spiny dogfish Alkane, liquid monoesters and lipid composition, the content of the high-efficiency moisturizing composition each component are as follows: by percentage to the quality, saualane 50-95%, liquid monoesters 3-30%, lipid 0.1-20%.
3. high-efficiency moisturizing composition according to claim 1 or 2, which is characterized in that the source of the saualane be animal, Plant or fermentation obtain.
4. high-efficiency moisturizing composition according to claim 3, which is characterized in that the source of the saualane is to ferment It arrives.
5. high-efficiency moisturizing composition according to claim 1 or 2, which is characterized in that serve as reasons in the source of the liquid monoesters Formula is what the fatty acid of R- (COOH) n was reacted with alcohol, and wherein R is the aryl of the alkyl of C2-C45, C2-C45, the alkane Base is direct-connected or branch saturated or unsaturated alkyl, and the aryl is one or more phenyl with substituent group, described Substituent group is linear saturation alkyl, straight chain unsaturated alkyl, branch saturated alkyl or branch unsaturated alkyl, and n is more than or equal to 1, The alcohol is the alcohols or polyglycereol that the degree of polymerization is 2-8.
6. high-efficiency moisturizing composition according to claim 5, which is characterized in that the liquid monoesters are the different tristearin of polyglycereol Acid esters.
7. high-efficiency moisturizing composition according to claim 1 or 2, which is characterized in that the lipid is fatty acid, glycerol One of lipid, glycerophosphatide class, sphingolipid, sterol lipid, pregnenolone lipid, glycolipid class, poly vinyl are a variety of Mixture.
8. high-efficiency moisturizing composition according to claim 7, which is characterized in that the lipid is caprylic/capric glycerol three One of ester, cholesterol, ceramide, lecithin, oleic acid, lanonol or a variety of mixtures.
CN201910216766.6A 2019-03-21 2019-03-21 A kind of high-efficiency moisturizing composition Pending CN109806177A (en)

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Publication number Priority date Publication date Assignee Title
CN110101618A (en) * 2019-05-29 2019-08-09 尚赫(天津)科技开发有限公司 Using the moisture-keeping composition of 4XMoisLock quadruple molecular layer water lock technology
CN112245315A (en) * 2020-10-14 2021-01-22 广州环亚化妆品科技有限公司 Ceramide facial mask with moisturizing and repairing effects and preparation method thereof
CN113018221A (en) * 2021-03-03 2021-06-25 优牌智能科技(上海)有限公司 Lasting moisturizing lotion and preparation process thereof
CN113616545A (en) * 2021-09-23 2021-11-09 浙江初云品牌管理有限公司 Plant bionic skin lipid film and preparation method thereof
CN116747340A (en) * 2023-08-21 2023-09-15 露乐健康科技股份有限公司 Bionic fetal fat composition, paper diaper, preparation method and application of paper diaper

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CN107669522A (en) * 2017-11-14 2018-02-09 北京工商大学 A kind of method that the bionical skin care compositions suitable for youth of both sexes is prepared based on skin lipid group
CN108498382A (en) * 2018-06-28 2018-09-07 武汉百思凯瑞生物科技有限公司 A kind of moisturizing conveys nano-composition and its preparation method and application altogether

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN110101618A (en) * 2019-05-29 2019-08-09 尚赫(天津)科技开发有限公司 Using the moisture-keeping composition of 4XMoisLock quadruple molecular layer water lock technology
CN112245315A (en) * 2020-10-14 2021-01-22 广州环亚化妆品科技有限公司 Ceramide facial mask with moisturizing and repairing effects and preparation method thereof
CN113018221A (en) * 2021-03-03 2021-06-25 优牌智能科技(上海)有限公司 Lasting moisturizing lotion and preparation process thereof
CN113616545A (en) * 2021-09-23 2021-11-09 浙江初云品牌管理有限公司 Plant bionic skin lipid film and preparation method thereof
CN116747340A (en) * 2023-08-21 2023-09-15 露乐健康科技股份有限公司 Bionic fetal fat composition, paper diaper, preparation method and application of paper diaper
CN116747340B (en) * 2023-08-21 2023-11-24 露乐健康科技股份有限公司 Bionic fetal fat composition, paper diaper, preparation method and application of paper diaper

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