CN109966167A - A kind of lip treatment composition and preparation method thereof - Google Patents
A kind of lip treatment composition and preparation method thereof Download PDFInfo
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- CN109966167A CN109966167A CN201910167948.9A CN201910167948A CN109966167A CN 109966167 A CN109966167 A CN 109966167A CN 201910167948 A CN201910167948 A CN 201910167948A CN 109966167 A CN109966167 A CN 109966167A
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- treatment composition
- mixed ester
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- lip
- wax
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 150000002148 esters Chemical class 0.000 claims abstract description 56
- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 claims abstract description 46
- CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 claims abstract description 46
- XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 claims abstract description 46
- FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 claims abstract description 46
- BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 claims abstract description 46
- LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 claims abstract description 46
- CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 claims abstract description 46
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 claims abstract description 46
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 claims abstract description 46
- 229940058690 lanosterol Drugs 0.000 claims abstract description 46
- 239000002253 acid Substances 0.000 claims abstract description 44
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 42
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 21
- 239000008158 vegetable oil Substances 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 239000001993 wax Substances 0.000 claims description 21
- 239000003963 antioxidant agent Substances 0.000 claims description 12
- 230000003078 antioxidant effect Effects 0.000 claims description 12
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 11
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 11
- 229940057910 shea butter Drugs 0.000 claims description 10
- 235000013871 bee wax Nutrition 0.000 claims description 8
- 239000012166 beeswax Substances 0.000 claims description 8
- 239000004200 microcrystalline wax Substances 0.000 claims description 8
- 239000004203 carnauba wax Substances 0.000 claims description 7
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 5
- 235000010384 tocopherol Nutrition 0.000 claims description 5
- 229960001295 tocopherol Drugs 0.000 claims description 5
- 229930003799 tocopherol Natural products 0.000 claims description 5
- 239000011732 tocopherol Substances 0.000 claims description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 5
- 239000004250 tert-Butylhydroquinone Substances 0.000 claims description 4
- 235000019281 tert-butylhydroquinone Nutrition 0.000 claims description 4
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 3
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 3
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims description 3
- 229960005215 dichloroacetic acid Drugs 0.000 claims description 3
- 235000009566 rice Nutrition 0.000 claims description 3
- 239000003760 tallow Substances 0.000 claims description 3
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 239000010466 nut oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims 1
- 240000000912 Macadamia tetraphylla Species 0.000 claims 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 20
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 abstract description 3
- 206010013786 Dry skin Diseases 0.000 abstract description 3
- 230000037336 dry skin Effects 0.000 abstract description 3
- 210000002374 sebum Anatomy 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 230000004888 barrier function Effects 0.000 abstract description 2
- 230000000474 nursing effect Effects 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 235000006708 antioxidants Nutrition 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000003098 cholesteric effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 229940099259 vaseline Drugs 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 229930182558 Sterol Natural products 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000013065 commercial product Substances 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 238000004299 exfoliation Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 150000003432 sterols Chemical class 0.000 description 3
- 235000003702 sterols Nutrition 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229940044119 2-tert-butylhydroquinone Drugs 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000144217 Limnanthes alba Species 0.000 description 1
- 206010024552 Lip dry Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000019488 nut oil Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000037309 reepithelialization Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of lip treatment composition and preparation method thereof, lip treatment composition includes following effective component by weight: C10-30 acid cholesterine/50-80 parts of lanosterol mixed ester；1-40 parts of vegetable oil；5-25 parts of wax；The preparation method of lip treatment composition includes: mixing step: wax being dissolved by heating, vegetable oil is then added and mixes, at least 30min is kept the temperature after being heated to 75-90 DEG C, obtains pre-composition；Addition mixed ester step: C10-30 acid cholesterine/lanosterol mixed ester is added in pre-composition and mixes, obtains lip treatment composition；C10-30 acid cholesterine/lanosterol mixed ester containing a large amount, its chemical structure is similar with the sebum of skin, ability with stronger affine water, the cuticula of not sticky human skin is formed on the skin, the barrier action of the water content and skin of skin is adjusted, it is very valuable to the nursing of dry skin.
Description
Technical field
The present invention relates to a kind of lip treatment compositions and preparation method thereof, belong to skin caring ingredient technical field.
Background technique
Lip skin color is ruddy, smooth and obvious, but does not have subcutaneous fat, will not voluntarily secrete moisture with grease, than
The delicate sensitivity of other skin of human body；It is highly susceptible to the influence of external environment, such as computer, mobile phone radiation, dry, ultraviolet light
Infringement, living environment pollution and the increase at itself age, work it is tired, can all cause lip dry, crack, relaxation, secretly
It is heavy, the problems such as wrinkle.
Lip care product major function be make the lasting moisturizing of lip skin, while releive maintenance lip skin and prevention lip
The bad phenomenons such as portion's dry skin, decortication, cracking.The type of lip care product is more and more, and function is also gradually diversified.However city
It is existing on field that there is the lip gloss for moistening moisturizing substantially not have repair function to lip, for having had inflammation, decortication
Crack, burn, swelling, itch, exfoliation, mild pain the problems such as lip skin, existing lip care product effect is unobvious
And have certain side effect, be applied on lip for a long time, especially diet when a part product enter in vivo, be used for a long time pair
Body generates certain influence.
Summary of the invention
For overcome the deficiencies in the prior art, the first purpose of this invention is to provide a kind of lip treatment composition, contains
C10-30 acid cholesterine/lanosterol mixed ester of a large amount, chemical structure is similar with the sebum of skin, has stronger affine
The ability of water, forms the cuticula of not sticky human skin on the skin, and the decortication of maintenance lip cracks, burns, swelling, scabies
Itch, exfoliation, the inflammation such as mild pain can play deeply preserving moisture and nourish, desalinate cheilogramma, prevent lip cracking or peeling from falling
Skin and can quickly heal because of chap etc. wound or slight crack etc. caused by reasons.
Second object of the present invention is to provide a kind of preparation method of above-mentioned lip treatment composition.
Realize that the first purpose of this invention can reach by adopting the following technical scheme that: a kind of lip treatment composition, packet
Include following effective component by weight:
C10-30 acid cholesterine/50-80 parts of lanosterol mixed ester；
1-40 parts of vegetable oil；
5-25 parts of wax.
Further, C10-30 acid cholesterine/lanosterol mixed ester includes the first C10-30 acid cholesterine/lanosterol
Mixed ester and the 2nd C10-30 acid cholesterine/lanosterol mixed ester；First C10-30 acid cholesterine/lanosterol mixed ester
Slip point is 37.3 DEG C；2nd C10-30 acid cholesterine/lanosterol mixed ester slip point is 12 DEG C.
Further, the first C10-30 acid cholesterine/lanosterol mixed ester parts by weight are 40-60 parts；2nd C10-
The parts by weight of 30 sour cholesterine/lanosterol mixed esters are 10-20 parts.
Further, vegetable oil includes at least one of shea butter, olive oil, macadimia nut oil and pond flower seed oil.
Further, vegetable oil includes 1-15 parts and 1-25 parts of pond flower seed oil of shea butter.
Further, wax include in Brazil wax, candelila wax, beeswax, haze tallow, rice wax, ceresine and microwax extremely
Few one kind.
Further, wax includes 4-6 parts of candelila wax；3-8 parts of beeswax；1-3 parts and microwax 2-5 parts of Brazil wax.
Further, lip treatment composition further includes antioxidant；Antioxidant includes butylated hydroxy anisole, dibutyl hydroxyl
At least one of base toluene, tert-butyl hydroquinone and tocopherol.
Realize that second object of the present invention can reach by adopting the following technical scheme that: a kind of lip care as described above
The preparation method of composition, comprising:
Mixing step: wax is dissolved by heating, and vegetable oil is then added and mixes, keeps the temperature at least after being heated to 75-90 DEG C
30min obtains pre-composition；
Addition mixed ester step: C10-30 acid cholesterine/lanosterol mixed ester is added in pre-composition and mixes, obtains
Lip treatment composition.
Further, preparation method further includes addition antioxidant step: after addition mixed ester step, being cooled to 60-
66 DEG C, antioxidant is added and mixes, obtains lip treatment composition.
Signified lip treatment composition of the invention, form include but is not limited to solid-state, gel state, newborn state, liquid etc..
Compared with prior art, the beneficial effects of the present invention are:
1, lip treatment composition of the invention, C10-30 acid cholesterine/lanosterol mixed ester containing a large amount, chemistry knot
Structure is similar with the sebum of skin, and the ability with stronger affine water forms the cuticula of not sticky human skin on the skin,
The barrier action of the water content and skin of skin is adjusted, it is very valuable to the nursing of dry skin, and for by breakage
Skin, the decortication of maintenance lip cracks, burns, swelling, itch, exfoliation, the inflammation such as mild pain, can play depth guarantor
It is wet nourish, desalinate cheilogramma, prevent lip crack or peeling scaling and can quickly heal because of chap etc. caused by reasons wound or
The effects of slight crack；
2, lip treatment composition good permeability of the invention, can quickly be absorbed by the skin, and it is moist and high to not only act as deep layer
Moisture-keeping function is imitated, the skin problem being effective against under the gentle solution environmental pressure of skin aging problem improves lip local microcirculation,
Eubolism is restored, enables the more plentiful smooth, sharp outline of lips and water profit red tender；
3, lip treatment composition of the invention does not add artificial synthesized pigment, essence and preservative, is effectively reduced to lip
The stimulation and influence of portion's skin not will cause the discomfort of lip skin, and mild, non-stimulated, and all kinds of skin quality crowds is suitble to make
With.
Detailed description of the invention
Fig. 1 is the corresponding broken line diagram of mean skin water content；
Fig. 2 is the corresponding broken line diagram of mean skin water loss amount；
Fig. 3 is the lip picture for repairing skin of lip measure of merit subject damage；
Fig. 4-5 is to use the lip picture after embodiment 11 weeks, 2 weeks；
Fig. 6-7 is to use the lip picture after vaseline 1 week, 2 weeks.
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the present invention:
Each active ingredient raw materials can be bought from chemical industry or medical market in lip treatment composition, including but not limited to following
Producer.
A kind of lip treatment composition, including following effective component by weight:
First C10-30 acid cholesterine/lanosterol mixed ester slip point is 37.3 DEG C；2nd C10-30 acid cholesteric
Alcohol/lanosterol mixed ester slip point is 12 DEG C, mixed using C10-30 acid cholesterine/lanosterol of different slip points
It closes ester to be mixed in a certain ratio, is conducive to the molding of lip treatment composition.
First C10-30 acid cholesterine/lanosterol mixed ester is purchased from the Super Sterol Liquid- of Croda company
SO- (JP), the 2nd C10-30 acid cholesterine/lanosterol mixed ester are purchased from the Super Sterol ester- of Croda company
SO- (JP), shea butter are purchased from the Lipex shea of AAK group, and pond flower seed oil is purchased from the Meadowfoam of Elementis company
Seed Oil。
C10-30 acid cholesterine/lanosterol mixed ester, has been certified and has been present in human skin angle in lip treatment composition
Ingredient in the lipid and hair cell membrane of matter layer is a kind of pure natural nontoxic non-stimulated ingredient, is a kind of skin condition, repairs
Shield and moisturizer, structure is similar with lipid structure in skin itself cuticula, due to its bio-compatibility and its complicated group
At make it become a kind of very special natural skin softening agent.It is the mixture of one kind of multiple esters, mainly by branch
Fatty acid, cholesterine and corresponding sterols composition, are easily absorbed by the body, can not only prevent season cracking, moreover it is possible to further
The natural elasticity for restoring and keeping skin has effects that the moist of deep layer, can promote reepithelialization, assign skin-nourishing
Effect can provide a series of therapeutic effect to skin.
Wax includes at least one of Brazil wax, candelila wax, beeswax, haze tallow, rice wax, ceresine and microwax；It is anti-
Oxidant includes at least one of butylated hydroxy anisole, dibutyl hydroxy toluene, tert-butyl hydroquinone and tocopherol.
The preparation method of above-mentioned lip treatment composition, comprising:
Sterilisation step: it is that 80-100 DEG C of aqua sterilisa cleans the instruments Appliances including reaction kettle with temperature, then uses
75vt% ethanol for disinfection rinses, cold wind drying；
Mixing step: wax being added in reaction kettle and is dissolved by heating, and shea butter and pond flower seed oil is then added and mixes, adds
Heat obtains pre-composition at least 30min is kept the temperature after 75-90 DEG C；
It adds mixed ester step: the first C10-30 acid cholesterine/lanosterol mixed ester and second being added in pre-composition
C10-30 acid cholesterine/lanosterol mixed ester simultaneously mixes；
Add antioxidant step: after addition mixed ester step, being cooled to 60-66 DEG C, antioxidant is added and mixes, obtains
Lip treatment composition.
Embodiment 1-3:
It is a kind ofPasteLip treatment composition, including following effective component as shown in Table 1 by weight:
The Parts by Ingredients of 1 embodiment 1-3 of table
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| First C10-30 acid cholesterine/lanosterol mixed ester | 41 | 45 | 50 |
| 2nd C10-30 acid cholesterine/lanosterol mixed ester | 19 | 15 | 11 |
| Shea butter | 5 | 10 | 10 |
| Pond flower seed oil | 19.8 | 12.2 | 15 |
| Candelila wax | 4.5 | 5.5 | 5 |
| Beeswax | 5 | 6 | 4.5 |
| Brazil wax | 2.5 | 2 | 3 |
| Microwax | 3 | 4 | 3 |
| Tocopherol | 0.2 | 0.3 | 0.5 |
First C10-30 acid cholesterine/lanosterol mixed ester slip point is 37.3 DEG C；2nd C10-30 acid cholesteric
Alcohol/lanosterol mixed ester slip point is 12 DEG C.
The preparation method of above-mentioned lip treatment composition, comprising:
Sterilisation step: it is that 80-100 DEG C of aqua sterilisa cleans the instruments Appliances including reaction kettle with temperature, then uses
75vt% ethanol for disinfection rinses, cold wind drying；
Mixing step: candelila wax, beeswax, Brazil wax and microwax are added in reaction kettle and dissolved by heating, then
Shea butter and pond flower seed oil is added and mixes, at least 30min is kept the temperature after being heated to 75-90 DEG C, obtains pre-composition；
It adds mixed ester step: the first C10-30 acid cholesterine/lanosterol mixed ester and second being added in pre-composition
C10-30 acid cholesterine/lanosterol mixed ester simultaneously mixes；
Add antioxidant step: after addition mixed ester step, being cooled to 60-66 DEG C, tocopherol is added and mixes, is protected
Lip composition.
Embodiment 4-6:
It is a kind ofEssence liquidLip treatment composition, including following effective component as shown in Table 2 by weight:
The Parts by Ingredients of 2 embodiment 4-6 of table
| Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| First C10-30 acid cholesterine/lanosterol mixed ester | 41 | 45 | 50 |
| 2nd C10-30 acid cholesterine/lanosterol mixed ester | 19 | 15 | 11 |
| Shea butter | 12.5 | 10 | 10 |
| Pond flower seed oil | 12.47 | 16.97 | 17.97 |
| Beeswax | 15 | 13 | 12 |
| Tert-butyl hydroquinone | 0.03 | 0.03 | 0.03 |
First C10-30 acid cholesterine/lanosterol mixed ester slip point is 37.3 DEG C；2nd C10-30 acid cholesteric
Alcohol/lanosterol mixed ester slip point is 12 DEG C.
The preparation method is the same as that of Example 1-3 by embodiment 4-6.
Embodiment 7-9:
It is a kind ofGel stateLip treatment composition, including following effective component as shown in Table 3 by weight:
The Parts by Ingredients of 3 embodiment 7-9 of table
| Embodiment 7 | Embodiment 8 | Embodiment 9 | |
| First C10-30 acid cholesterine/lanosterol mixed ester | 41 | 45 | 55 |
| 2nd C10-30 acid cholesterine/lanosterol mixed ester | 15 | 19 | 11 |
| Shea butter | 14 | 10 | 14 |
| Pond flower seed oil | 14.97 | 10.97 | 10.97 |
| Microwax | 10 | 10 | 7 |
| Beeswax | 5 | 4 | 2 |
| Tert-butyl hydroquinone | 0.03 | 0.03 | 0.03 |
First C10-30 acid cholesterine/lanosterol mixed ester slip point is 37.3 DEG C；2nd C10-30 acid cholesteric
Alcohol/lanosterol mixed ester slip point is 12 DEG C.
The preparation method is the same as that of Example 1-3 by embodiment 7-9.
Performance detection:
1, moisture-keeping efficacy test is done in the product made to above-described embodiment 1-9 and commercial product respectively, test method: with
Machine chooses skin health, 30 subjects of no skin disease and allergies, and chooses the flexion of upper limb lateral areas proper area of subject
For test section.Skin is used by clear water cleaning, then naturally dry 15min after uniformly being wiped with alcohol in tested region before test
Moisture measurer (825 skinanalysis apparatus of CM) and water loss measuring appliance (
TM300 moisture content of skin (blank value) and skin water loss amount (blank value) before not smearing sample) are measured.Before subject
Two kinds of samples of 30mg are uniformly coated on the inside of arm in the range of 3cm × 3cm respectively, after being uniformly applied to absorption.Use moisture of skin
After measurer and water loss measuring appliance measure smearing 30min respectively, after 1h, after 2h, after 3h, after 4h, after 5h, after 6h, 7h
Afterwards, the moisture content of skin after 8h and water loss amount compare the mean skin water content at two sample each time points, as a result chart
Shown in lattice 4 and Fig. 1, mean skin water loss amount, as a result as shown in table 5 and Fig. 2:
The mean skin water content of 4 embodiment 1-9 of table
The mean skin water loss amount of 5 embodiment 1-9 of table
The results show that applying the mean skin water content after embodiment 1-9 is slightly above the mean skin after smearing commercial product
Moisture content value, the mean skin water loss amount after smearing embodiment 1-9 are slightly below the mean skin water after smearing commercial product
Vector is shunted, in embodiment, the moisturizing effect of embodiment 1-3 is best.
2, skin of lip measure of merit is repaired:
Test sample: embodiment 1
Control: vaseline
Test method: 0.03- is coated respectively within the scope of the lip of the established dry and cracked wound of subject sooner or later daily
The sample of 0.06g and control, after substantially uniformity is applied to absorption.Before sample is smeared in observation respectively, after 1 week, dry and cracked wound after 2 weeks
Repairing effect.
Fig. 3 is using the lip degree of impairment picture before product, and Fig. 4-5 is respectively after smearing embodiment 11 weeks, after 2 weeks
The case where improve picture, Fig. 6-7 is respectively that the situation after smearing vaseline 1 week, after 2 weeks improves picture.The results show that using real
Dry and cracked wound after applying example 12 weeks obviously improves, and synchronizes and do not become using the dry and cracked wound of vaseline alternate embodiment 1
Change, illustrates that the lip repair product of ester containing lanosterol has the effect for repairing dry and cracked wound.
For those skilled in the art, it can make other each according to the above description of the technical scheme and ideas
Kind is corresponding to be changed and deforms, and all these change and deform the protection model that all should belong to the claims in the present invention
Within enclosing.
Claims (10)
1. a kind of lip treatment composition, which is characterized in that including following effective component by weight:
C10-30 acid cholesterine/50-80 parts of lanosterol mixed ester；
1-40 parts of vegetable oil；
5-25 parts of wax.
2. lip treatment composition as described in claim 1, which is characterized in that the C10-30 acid cholesterine/lanosterol mixing
Ester includes the first C10-30 acid cholesterine/lanosterol mixed ester and the 2nd C10-30 acid cholesterine/lanosterol mixed ester；Institute
Stating the first C10-30 acid cholesterine/lanosterol mixed ester slip point is 37.3 DEG C；The 2nd C10-30 acid cholesterine/
The slip point of lanosterol mixed ester is 12 DEG C.
3. lip treatment composition as claimed in claim 2, which is characterized in that the first C10-30 acid cholesterine/lanosterol
The parts by weight of mixed ester are 40-60 parts；The parts by weight of the 2nd C10-30 acid cholesterine/lanosterol mixed ester are 10-20
Part.
4. lip treatment composition as described in claim 1, which is characterized in that the vegetable oil includes shea butter, olive oil, Australia
At least one of continent macadamia nut oil and pond flower seed oil.
5. lip treatment composition as described in claim 1, which is characterized in that the vegetable oil includes 1-15 parts of shea butter and pond
1-25 parts of flower seed oil.
6. lip treatment composition as described in claim 1, which is characterized in that the wax includes Brazil wax, candelila wax, bee
At least one of wax, haze tallow, rice wax, ceresine and microwax.
7. lip treatment composition as described in claim 1, which is characterized in that the wax includes 4-6 parts of candelila wax；Beeswax 3-8
Part；1-3 parts and microwax 2-5 parts of Brazil wax.
8. lip treatment composition as described in claim 1, which is characterized in that the lip treatment composition further includes antioxidant；Institute
Stating antioxidant includes at least one in butylated hydroxy anisole, dibutyl hydroxy toluene, tert-butyl hydroquinone and tocopherol
Kind.
9. a kind of preparation method of lip treatment composition as described in claim 1, characterized by comprising:
Mixing step: wax is dissolved by heating, and vegetable oil is then added and mixes, at least 30min is kept the temperature after being heated to 75-90 DEG C,
Obtain pre-composition；
Addition mixed ester step: C10-30 acid cholesterine/lanosterol mixed ester is added in pre-composition and mixes, obtains lip care
Composition.
10. the preparation method of lip treatment composition as claimed in claim 9, which is characterized in that preparation method further includes addition
Antioxidant step: after addition mixed ester step, being cooled to 60-66 DEG C, and antioxidant is added and mixes, and obtains lip care combination
Object.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111821212A (en) * | 2020-08-17 | 2020-10-27 | 齐鲁工业大学 | Food-grade lipstick and preparation method thereof |
| CN114028268A (en) * | 2021-10-21 | 2022-02-11 | 曼秀雷敦(中国)药业有限公司 | Natural plant component lip balm and preparation method thereof |
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| US20130142745A1 (en) * | 2010-09-13 | 2013-06-06 | Chanel Parfums Beaute | Cosmetic composition for lip make-up |
| CN104352361A (en) * | 2014-11-20 | 2015-02-18 | 广州神采化妆品有限公司 | Variable-colour transparent lipstick and preparation method thereof |
| CN106137795A (en) * | 2016-08-15 | 2016-11-23 | 广州澳希亚实业有限公司 | Composition for inhibiting sweating of lip balm and repairing lip injury |
| CN106902027A (en) * | 2017-02-17 | 2017-06-30 | 曼秀雷敦(中国)药业有限公司 | A kind of lip care product of high content shea butter and preparation method thereof |
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| US20130142745A1 (en) * | 2010-09-13 | 2013-06-06 | Chanel Parfums Beaute | Cosmetic composition for lip make-up |
| CN104352361A (en) * | 2014-11-20 | 2015-02-18 | 广州神采化妆品有限公司 | Variable-colour transparent lipstick and preparation method thereof |
| CN106137795A (en) * | 2016-08-15 | 2016-11-23 | 广州澳希亚实业有限公司 | Composition for inhibiting sweating of lip balm and repairing lip injury |
| CN106902027A (en) * | 2017-02-17 | 2017-06-30 | 曼秀雷敦(中国)药业有限公司 | A kind of lip care product of high content shea butter and preparation method thereof |
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| CN111821212A (en) * | 2020-08-17 | 2020-10-27 | 齐鲁工业大学 | Food-grade lipstick and preparation method thereof |
| CN111821212B (en) * | 2020-08-17 | 2022-12-13 | 齐鲁工业大学 | Food-grade lipstick and preparation method thereof |
| CN114028268A (en) * | 2021-10-21 | 2022-02-11 | 曼秀雷敦(中国)药业有限公司 | Natural plant component lip balm and preparation method thereof |
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