CN109223664A - A kind of skin cream and preparation method preventing and treating eczema, bite by mosquitos - Google Patents
A kind of skin cream and preparation method preventing and treating eczema, bite by mosquitos Download PDFInfo
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- CN109223664A CN109223664A CN201811440850.8A CN201811440850A CN109223664A CN 109223664 A CN109223664 A CN 109223664A CN 201811440850 A CN201811440850 A CN 201811440850A CN 109223664 A CN109223664 A CN 109223664A
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- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 24
- 239000002884 skin cream Substances 0.000 title claims abstract description 23
- 208000010668 atopic eczema Diseases 0.000 title claims abstract description 22
- 241000256113 Culicidae Species 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000002994 raw material Substances 0.000 claims abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 244000021150 Orbignya martiana Species 0.000 claims abstract description 12
- 235000014643 Orbignya martiana Nutrition 0.000 claims abstract description 11
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 11
- 230000002265 prevention Effects 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- 235000019198 oils Nutrition 0.000 claims description 19
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 16
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 12
- 235000013399 edible fruits Nutrition 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 235000021314 Palmitic acid Nutrition 0.000 claims description 8
- 229940036350 bisabolol Drugs 0.000 claims description 8
- 150000001720 carbohydrates Chemical class 0.000 claims description 8
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 7
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 7
- 229930182478 glucoside Natural products 0.000 claims description 7
- 150000008131 glucosides Chemical class 0.000 claims description 7
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 7
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 7
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 7
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 7
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 7
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 6
- 229930064664 L-arginine Natural products 0.000 claims description 6
- 235000014852 L-arginine Nutrition 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 229940100460 peg-100 stearate Drugs 0.000 claims description 6
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 5
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 5
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 5
- 229960001631 carbomer Drugs 0.000 claims description 5
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000000155 melt Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 206010013786 Dry skin Diseases 0.000 abstract description 7
- 230000037336 dry skin Effects 0.000 abstract description 7
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 230000006378 damage Effects 0.000 abstract description 4
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 3
- 239000003908 antipruritic agent Substances 0.000 abstract description 3
- 239000000686 essence Substances 0.000 abstract description 3
- 208000014674 injury Diseases 0.000 abstract description 3
- 239000000049 pigment Substances 0.000 abstract description 3
- 239000003755 preservative agent Substances 0.000 abstract description 3
- 230000002335 preservative effect Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 17
- 239000003921 oil Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 10
- 239000000047 product Substances 0.000 description 8
- 235000014633 carbohydrates Nutrition 0.000 description 6
- -1 dimethyl siloxane Chemical class 0.000 description 4
- 241000255925 Diptera Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 206010033474 Pain of skin Diseases 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- 239000010480 babassu oil Substances 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000077 insect repellent Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010012444 Dermatitis diaper Diseases 0.000 description 1
- 208000003105 Diaper Rash Diseases 0.000 description 1
- 206010014198 Eczema infantile Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 241001448624 Miliaria Species 0.000 description 1
- 244000270834 Myristica fragrans Species 0.000 description 1
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- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
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- 206010042496 Sunburn Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000705931 Zelkova schneideriana Species 0.000 description 1
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- 206010000496 acne Diseases 0.000 description 1
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- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000001138 artemisia absinthium Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
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- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000013310 margarine Nutrition 0.000 description 1
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- 239000005017 polysaccharide Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of prevention and treatment eczema, the skin cream of bite by mosquitos, it is related to daily chemical product technical field, the skin cream is by A group raw material, B group raw material, C group raw material, D group raw material and E group raw material composition, the raw material that this skin cream uses is naturally organic, without essence, pigment, preservative etc., it does not stimulate mildly, suitable for adult and baby, and it is acted synergistically according to plurality of raw materials, it can effectively releive and treat eczema, dry skin, the red wind wind of baby, have effects that antipruritic disappear is wrapped to bite by mosquitos, there is good spreadability using Babassu seed oil simultaneously, it prevents from causing secondary injury to skin when treatment.
Description
Technical field:
The present invention relates to daily chemical product technical fields, and in particular to a kind of moisturizing for preventing and treating eczema, bite by mosquitos
Frost and preparation method.
Background technique:
Skin is the maximum organ of human body, plays a part of protecting human body not by outside stimulus or injury, however for the summer
When autumn, exposed skin, including arm, leg, neck etc. are subject to biting to mosquito, can make after scratching repeatedly
Cracked skin, infection, and since summer and autumn are the seasonal variations phase, phenomena such as skin is easy to appear itch, season cracking and eczema,
So that the skin sup sorrow of people, or even directly affect daily life.
Currently, with advances in technology with development, also occur on the market many prevention bite by mosquitos, treatment bite by mosquitos and
The product of eczema, such as floral water, zicao soft plaster are treated, but most of these products are product only with single effect, for
It is then very rare that prevention and treatment eczema, the skin cream of bite by mosquitos can be had both, and most of existing product chemistry closes
At, containing essence, pigment, preservative etc., it is irritating to the skin effect, is not suitable for the skin that baby is delicate, sensitive, so that
Existing product limitation is big, and in order to solve the above-mentioned technical problem, spy proposes a kind of new technical solution.
Summary of the invention:
In place of overcoming above-mentioned the shortcomings of the prior art, and provide a kind of prevention and treatment
Eczema, the skin cream of bite by mosquitos and preparation method.
The technical solution adopted by the present invention are as follows: it is a kind of prevent and treat eczema, bite by mosquitos skin cream, the skin cream by
A group raw material, B group raw material, C group raw material, D group raw material and E group raw material composition.
The A group raw material by cetostearyl alcohol, cetearyl glucoside, dimethyl silicone polymer, glycerol stearate,
PEG-100 stearate, saualane, bitter oily seeds of trees oil, Babassu seed oil and the auspicious palmitic acid fruit oil composition of hair, B group raw material is by glycerol, life
Object carbohydrate gum -1, carbomer, Sodium Hyaluronate, EDETATE SODIUM and pure water composition, C group raw material are made of L-arginine, D group raw material
It is made of-bisabolol and Folium Artemisiae Argyi extractive liquid, E group raw material is made of 1,2- pentanediol and Sensiva SC50.
The parts by weight of the A group feed components are cetostearyl alcohol 1-3 parts, 1-3 parts of cetearyl glucoside, gather
1-3 parts of dimethyl siloxane, 0.5-1.5 parts of glycerol stearate, 0.5-1.5 parts of PEG-100 stearate, 3-10 parts of saualane,
0.1-0.5 parts of bitter 1-5 parts of seeds of trees oil of oil, 1-5 parts of Babassu seed oil and hair auspicious palmitic acid fruit oil, the weight of the B group feed components
Measure part be glycerol 1-10 part, biology -11.5-5 parts of carbohydrate gum, 0.05-0.25 parts of carbomer, 0.25-0.75 parts of Sodium Hyaluronate,
0.25-0.75 parts of EDETATE SODIUM and pure water surplus, the parts by weight of the C group feed components are L-arginine 0.09-0.27
Part, the parts by weight of the D group raw material components are -0.08-0.2 parts of bisabolol, 0.5-2 parts of Folium Artemisiae Argyi extractive liquid, the E
The parts by weight of group raw material components are 1-3 parts of 1,2- pentanediol and 0.25-0.75 parts of Sensiva SC50.
A kind of prevention and treatment eczema, the preparation method of bite by mosquitos skin cream, the preparation method the following steps are included:
(1) component A is sequentially added in emulsifying device oil cauldron, is heated to 75-85 degree to whole components and melts completely, obtains
Mixture A.
(2) items in component B are sequentially added in emulsifying device kettle, is heated with stirring to 80-90 degree, homogeneous 3-5 minutes,
Continue stirring heat preservation, obtains mixed liquid B.
(3) mixture A and mixed liquid B are pumped into emulsion pot, homogeneous 3-5 minutes, are stirred evenly, kept the temperature 30 minutes, obtain
To mixture C.
(4) when mixture C being cooled to 70 degree, component C is added, homogeneous 2-3 minutes, carries out vacuum pumping, continues to stir
It mixes to substantially uniformity, obtains mixture D.
(5) mixture D is continued into stirring and is cooled to 4 degree hereinafter, to add component D and component E every, stirred evenly, examine
Test discharging.
The raw material of this skin cream is with the following functions:
1, South America Amazon tropic rain forest area, fruit of the Babassu seed oil extract from Babassu Babassu seed oil: are originated from
Core is rich in fatty acid, has antibacterial, inhibits microorganism and other effects, Babassu is widely used in food, margarine and sugar
In fruit.A series of triglycerides that Babassu seed oil is made of saturation and unsaturated fatty acid.Containing lauric acid 43%, nutmeg
Acid 13%, balanced ratio imparts its low-down fusing point (25 DEG C), has flexibility, emollient, high osmosis.Also it is rich in
There are glycoside, the nutriments such as vitamin.Compared to other vegetable fat (coconut oil, mango butter etc.), babassu oil does not glue
It is greasy, it not will increase skin and the burden of hair.Babassu oil have extraordinary spreadability, be capable of providing it is more soft, it is lighter
Skin sense.Especially suitable for eczema, the skin of drying, inflammation.
2, bitter oily seeds of trees oil: it is commonly called as An Deluoba oil.It is that Brazilian CEME (Central Medicines) filters out emphasis and grinds
One of medicinal plant studied carefully, for treating infectious dermatitis, moderate corium abscess ulcer, healing of wound and bringing down a fever；There is lemon
Bitter principle class, triterpene isoreactivity ingredient, inflammation-resisting itch-stopping prevent and treat infantile eczema, diaper rash；Calm skin and desalination color
Spot, inhibition and improvement fat granule；There is mosquito repellent function, can effectively prevent and treat bite by mosquitos；It is mainly used in reparation, treatment swashs
In the products such as plain dependence facial dermatitis, acne-removing inflammation-diminishing, baby's hip pad mosquito repellent.
3, the auspicious palmitic acid fruit oil of hair: it is commonly called as cloth Ritchie fruit oil, essential fatty acid and beta carotene rich in, are generally acknowledged
The highest natural materials of content beta-carotene；Visible light and ultraviolet light are absorbed, it is potent anti-oxidant, it can be used as solar filter
Alleviate dry skin and damage, treatment burn and sunburn, improves rubefaction phenomenon；Help skin cell regeneration and rehydrated work
With increasing elasticity of skin by protection collagen；Permeability is splendid, repairs impaired skin, reduces microgroove and wrinkle.
Biological carbohydrate gum -1: the polysaccharide from microbial fermentation, can counter infrared ray radiation, adjust skin temperature, be ideal
Skin reservoir, can lasting replenishing water and preserving moisture, it is rapid osmotic, mild non-stimulated.
4, Folium Artemisiae Argyi extractive liquid: natural wormwood source, mild antibiotic anti-inflammatory, Quick itch stopping are dispelled miliaria.
5 ,-bisabolol: extracting from Brazilian zelkova schneideriana, and natural organic, it is distinguished that antiallergic repairs effect.
The beneficial effects of the present invention are: the raw material that this skin cream uses is naturally organic, essence, pigment, preservative etc. are free of,
It does not stimulate mildly, is suitable for adult and baby, and act synergistically according to plurality of raw materials, can effectively releive and treat eczema, skin
Skin is dry, the red wind wind of baby, has effects that antipruritic disappear is wrapped to bite by mosquitos, while having good paving using Babassu seed oil
Malleability prevents from causing secondary injury to skin when treatment.
Specific embodiment:
Invention is further explained in conjunction with specific embodiments:
Embodiment one
The parts by weight of A group feed components are 1 part of cetostearyl alcohol, 1 part of cetearyl glucoside, gather in the skin cream
Oily 1 part of the seeds of trees oil of 1 part of dimethyl siloxane, 0.5 part of glycerol stearate, 0.5 part of PEG-100 stearate, 3 parts of saualane, hardship,
1 part of Babassu seed oil and mao auspicious palmitic acid fruit are 0.1 part oily, and the parts by weight of B group feed components are 1 part of glycerol, biological carbohydrate gum -11.5
Part, 0.05 part of carbomer, 0.25 part of Sodium Hyaluronate, 0.25 part of EDETATE SODIUM and pure water surplus, the weight of C group feed components
Part is 0.09 part of L-arginine, and the parts by weight of D group raw material components are -0.08 part of bisabolol, 0.5 part of Folium Artemisiae Argyi extractive liquid, E group
The parts by weight of raw material components are 1 part of 1,2- pentanediol and 0.25 part of Sensiva SC50；
Embodiment two
The parts by weight of A group feed components are 2 parts of cetostearyl alcohol, 2 parts of cetearyl glucoside, gather in the skin cream
2 parts of dimethyl siloxane, 1 part of glycerol stearate, 1 part of PEG-100 stearate, 5 parts of saualane, the bitter oily seeds of trees oily 3 parts, Ba Ba
3 parts of perilla oil and mao auspicious palmitic acid fruit are 0.3 part oily, and the parts by weight of B group feed components are 5 parts of glycerol, biological -13 parts of carbohydrate gum, card wave
0.01 part of nurse, 0.5 part of Sodium Hyaluronate, 0.5 part of EDETATE SODIUM and pure water surplus, the parts by weight of C group feed components are L- essence
0.18 part of propylhomoserin, the parts by weight of D group raw material components are -0.1 part of bisabolol, 1 part of Folium Artemisiae Argyi extractive liquid, the weight of E group raw material components
Measuring part is 2 parts of 1,2- pentanediol and 0.5 part of Sensiva SC50；
Embodiment three
The parts by weight of A group feed components are 3 parts of cetostearyl alcohol, 3 parts of cetearyl glucoside, gather in the skin cream
3 parts of dimethyl siloxane, 1.5 parts of glycerol stearate, 1.5 parts of PEG-100 stearate, 10 parts of saualane, bitter oily seeds of trees oil 5
Part, 5 parts of Babassu seed oil and mao auspicious palmitic acid fruit are 0.5 part oily, and the parts by weight of B group feed components are 10 parts of glycerol, biological carbohydrate gum -15
Part, 0.25 part of carbomer, 0.75 part of Sodium Hyaluronate, 0.75 part of EDETATE SODIUM and pure water surplus, the weight of C group feed components
Part is 0.27 part of L-arginine, and the parts by weight of D group raw material components are -0.2 part of bisabolol, 2 parts of Folium Artemisiae Argyi extractive liquid, E group raw material
The parts by weight of component are 3 parts of 1,2- pentanediol and 0.75 part of Sensiva SC50.
Three above embodiment is all made of following methods and is prepared:
(1) component A is sequentially added in emulsifying device oil cauldron, is heated to 75-85 degree to whole components and melts completely, obtains
Mixture A.
(2) items in component B are sequentially added in emulsifying device kettle, is heated with stirring to 80-90 degree, homogeneous 3-5 minutes,
Continue stirring heat preservation, obtains mixed liquid B.
(3) mixture A and mixed liquid B are pumped into emulsion pot, homogeneous 3-5 minutes, are stirred evenly, kept the temperature 30 minutes, obtain
To mixture C.
(4) when mixture C being cooled to 70 degree, component C is added, homogeneous 2-3 minutes, carries out vacuum pumping, continues to stir
It mixes to substantially uniformity, obtains mixture D.
(5) mixture D is continued into stirring and is cooled to 4 degree hereinafter, to add component D and component E every, stirred evenly, examine
Test discharging.
Physical and chemical index measurement
Using effect experiment:
Test one: this research is continuously tried out two months by 50 volunteers, is stung to a kind of prevention and treatment eczema, mosquito
The effect for stinging skin cream is investigated, test item standards of grading are as follows: very satisfied 5 points, is satisfied with 4 points, general 3 points, is unsatisfied with 2
Point, very dissatisfied 1 point.Wherein common group is common skin cream.
| Test item | Embodiment one | Embodiment two | Embodiment three | Common group |
| Eczema | 4.8 | 4.9 | 4.7 | 1.0 |
| Bite by mosquitos | 4.7 | 4.7 | 5.0 | 1.0 |
| Dry skin | 4.9 | 4.9 | 4.8 | 4.5 |
| Viscosity | 4.8 | 5.0 | 4.9 | 3.0 |
Test two: this research is continuously tried out two months by 50 volunteers, is stung to a kind of prevention and treatment eczema, mosquito
The effect for stinging skin cream is investigated, test item standards of grading are as follows: very satisfied 5 points, is satisfied with 4 points, general 3 points, is unsatisfied with 2
Point, very dissatisfied 1 point.Wherein common group is common antipruritic cream.
| Test item | Embodiment one | Embodiment two | Embodiment three | Common group |
| Eczema | 4.9 | 5.0 | 4.7 | 3.7 |
| Bite by mosquitos | 5.0 | 4.8 | 4.9 | 4.3 |
| Dry skin | 4.8 | 4.9 | 4.9 | 1.0 |
| Viscosity | 4.9 | 5.0 | 4.9 | 3.8 |
Test three:
By product release made of embodiment one, embodiment two and embodiment three in Guangdong Market, test product is to baby children
The effect of youngster's skin nursing is investigated, as a result as follows:
Dry skin: 99% effectively, can hold after improving the phenomenon that having dry skin, not cause allergic reaction.
The red wind wind of baby: 98% effectively, can the red wind wind of rapid recovery baby.
Bite by mosquitos: 98% effectively, and baby does not cry and scream, and does not scratch at mosquito bite.
In conclusion of the invention its can not only prevent and treat eczema, bite by mosquitos, dry skin, it is easily spread, and
Using it is safe, mildly do not stimulate.
For those skilled in the art, it is various corresponding that other can be made according to above technical scheme and design
Change and deformation, and all these change and modification all should belong within the scope of protection of the claims of the present invention.
Claims (4)
1. a kind of skin cream for preventing and treating eczema, bite by mosquitos, it is characterised in that: the skin cream is former by A group raw material, B group
Material, C group raw material, D group raw material and E group raw material composition.
2. a kind of skin cream for preventing and treating eczema, bite by mosquitos according to claim 1, it is characterised in that: described
A group raw material it is stearic by cetostearyl alcohol, cetearyl glucoside, dimethyl silicone polymer, glycerol stearate, PEG-100
Acid esters, saualane, bitter oily seeds of trees oil, Babassu seed oil and the auspicious palmitic acid fruit oil composition of hair, B group raw material is by glycerol, biological carbohydrate gum -1, card
Wave nurse, Sodium Hyaluronate, EDETATE SODIUM and pure water composition, C group raw material are made of L-arginine, and D group raw material is by-bisabolol
And Folium Artemisiae Argyi extractive liquid composition, E group raw material are made of 1,2- pentanediol and Sensiva SC50.
3. a kind of skin cream for preventing and treating eczema, bite by mosquitos according to claim 1, it is characterised in that: described
A group feed components parts by weight be cetostearyl alcohol 1-3 parts, 1-3 parts of cetearyl glucoside, dimethyl silicone polymer
1-3 parts, 0.5-1.5 parts of glycerol stearate, 0.5-1.5 parts of PEG-100 stearate, 3-10 parts of saualane, bitter oily seeds of trees oil 1-5
0.1-0.5 parts of part, 1-5 parts of Babassu seed oil and hair auspicious palmitic acid fruit oil, the parts by weight of the B group feed components are glycerol 1-10
Part, biological -11.5-5 parts of carbohydrate gum, 0.05-0.25 parts of carbomer, 0.25-0.75 parts of Sodium Hyaluronate, EDETATE SODIUM 0.25-
0.75 part and pure water surplus, the parts by weight of the C group feed components are L-arginine 0.09-0.27 parts, and the D group is former
The parts by weight for expecting component are -0.08-0.2 parts of bisabolol, 0.5-2 parts of Folium Artemisiae Argyi extractive liquid, the weight of the E group raw material components
Measuring part is 1-3 parts of 1,2- pentanediol and 0.25-0.75 parts of Sensiva SC50.
4. a kind of prevention and treatment eczema, the preparation method of bite by mosquitos skin cream, it is characterised in that: the preparation method include with
Lower step:
(1) component A is sequentially added in emulsifying device oil cauldron, is heated to 75-85 degree to whole components and melts completely, is mixed
Object A.
(2) items in component B are sequentially added in emulsifying device kettle, is heated with stirring to 80-90 degree, homogeneous 3-5 minutes, continues
Stirring heat preservation, obtains mixed liquid B.
(3) mixture A and mixed liquid B are pumped into emulsion pot, homogeneous 3-5 minutes, are stirred evenly, kept the temperature 30 minutes, mixed
Close object C.
(4) when mixture C being cooled to 70 degree, component C is added, homogeneous 2-3 minutes, carries out vacuum pumping, continues stirring extremely
Substantially uniformity obtains mixture D.
(5) mixture D is continued into stirring and is cooled to 45 degree hereinafter, to add component D and component E every, stirred evenly, verify
Material.
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| CN112640922A (en) * | 2020-12-24 | 2021-04-13 | 乐比(广州)健康产业有限公司 | Mosquito-repellent composition and preparation method and application thereof |
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Address after: 510000 room 318, Jiada Kechuang, No. 6, Yongjia Road, Jiahe street, Baiyun District, Guangzhou, Guangdong Applicant after: GUANGZHOU HEAN CHEMICAL Co.,Ltd. Address before: 510000 room 736, No. 1630, Jichang Road, Baiyun District, Guangzhou, Guangdong Applicant before: GUANGZHOU HEAN CHEMICAL Co.,Ltd. |
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Application publication date: 20190118 |