CN111374924A

CN111374924A - Baby wheat fresh extract raw pulp hip-protecting cream and preparation method thereof

Info

Publication number: CN111374924A
Application number: CN202010189999.4A
Authority: CN
Inventors: 罗成东; 孙永; 潘美红; 徐小建
Original assignee: Guangdong Kangaroo Mommy Biotechnology Co ltd
Current assignee: Guangdong Kangaroo Mommy Biotechnology Co ltd
Priority date: 2020-03-18
Filing date: 2020-03-18
Publication date: 2020-07-07

Abstract

The invention provides a baby wheat fresh extract raw stock hip-protecting cream and a preparation method thereof. The hip-protecting cream comprises: wheat germ extract, skin conditioner, oil, emulsifier, thickener, humectant and chelating agent; the skin conditioning agent comprises: bisabolol, wheat ceramide, phenytoin, antiallergic composition, Defushi, Terminalia catappa fruit extract and hydrolyzed wheat protein. The baby wheat fresh extract protoplasm hip-protecting cream is safe, mild and non-irritating, is free of mineral oil petrolatum, essence and preservative, has high-efficiency and allergy-relieving components, improves the barrier capability of baby skin, adjusts the colony balance of the baby skin, enhances the anti-inflammatory and anti-irritation capability of the skin, and has obvious effects of improving baby diaper rash, red rash and skin pruritus.

Description

Baby wheat fresh extract raw pulp hip-protecting cream and preparation method thereof

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a baby wheat fresh extract raw stock hip-protecting cream and a preparation method thereof.

Background

The skin of the infant is very delicate and moist, the stratum corneum is thin and fragile, and the skin can be damaged by any touch or slight stimulation. In modern society, infants of 0-18 months cannot clearly know when the infants need to excrete, so most parents can select paper diapers for their children, but the air permeability of most paper diapers cannot be completely ventilated, even some paper diapers are rough, the paper diapers are used for a long time, and the residual of excrement and urine can cause the moisture and sultry of the buttocks of the infants for a long time, so that the germs can be easily propagated on the surface of the skin in large quantities, the original skin microecology of the skin of the infants can be broken, the skin flora of the infants is unbalanced, and the skin inflammation is induced, wherein one of the most common skin diseases of the infants is diaper rash, commonly called as 'red butt thigh'.

Most of the existing baby hip-care cream products are added with high-content zinc oxide as a bacteriostatic agent, but the zinc oxide content is too high, so that the product is weak in alkalinity and high in irritation, and the formula stability is poor and the skin feeling is rough. Moreover, most of the existing baby hip-protecting cream products comprise synthetic grease, mineral oil and petrolatum, essence, preservative, emulsifier, humectant, thickener, antibacterial agent and the like. The skin care product has the effects that the zinc oxide is used for inhibiting bacteria, and meanwhile, a layer of protective film is formed on the surface of the skin by using mineral oil petrolatum, silicone oil and the like, so that the entering of some microorganisms such as bacteria and the like is blocked, partial residual excrement and urine are prevented from directly contacting the skin, the secondary infection is avoided, the effect of relieving the red buttocks is achieved, and the improvement and repair effects on the damaged skin with the symptoms of the red buttocks are not obvious.

CN110721150A discloses a baby hip cream and its preparation method, the baby hip cream comprises the following components: deionized water, grease, an antibacterial agent, a skin conditioner and an auxiliary agent; the skin conditioner comprises one or more of allantoin, bisabolol, hydroxyphenylpropionamide benzoic acid, lactobacillus fermentation product, cerevisiae Fermentum extract, yeast fermentation product filtrate or herba Polygoni Hydropiperis extract. The hip cream focuses on skin micro-ecology, adjusts imbalance of skin flora of infants from three dimensions of physics, chemistry and biology, and thoroughly solves the problem of 'red butt' of infants.

CN108703934A discloses an infant special hip cream, which comprises a component A and a component B, wherein the component A comprises the following components in parts by weight: 25-30 parts of vaseline, 20-30 parts of white mineral oil, 2-6 parts of candelilla wax, 5-15 parts of plukenetia xylostella palm seed fat, 1-3 parts of emulsifier, 0.1-0.5 part of antiseptic antibacterial agent, 0.05-0.1 part of menthoxy propylene glycol, 0.1-0.5 part of antioxidant and 5-15 parts of emollient, wherein the component B comprises the following components in parts by weight: 5-15 parts of glycerin and 5-15 parts of a skin conditioner. A protective film is formed on the surface of the skin through the candelilla wax, the malus lucidus fruit palm seed fat, the vaseline and the white mineral oil, and the health of the skin of the infant is guaranteed. .

Therefore, there is a need to develop a hip-protecting cream which is mild, non-irritant, capable of adjusting the colony balance of the skin of the infant, effectively improving and repairing the symptoms of 'red buttocks' of the infant, and bringing safer, more moisturizing and more effective protection to the infant

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide the baby wheat fresh extract protoplasm hip-protecting cream and the preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides a baby wheat fresh extract raw pulp hip-protecting cream, which is characterized by comprising the following components in parts by weight: wheat germ extract, skin conditioner, oil, emulsifier, thickener, humectant and chelating agent;

the skin conditioning agent comprises: bisabolol, wheat ceramide, phentermine, antiallergic composition (DEFENSIS), Defusel, Terminalia faba (TERMINALIA FERDINANDIANA) fruit extract, and hydrolyzed wheat protein.

According to the invention, the wheat germ extract, the skin conditioner and the oil are added into the baby wheat fresh extract protoplasm hip-protecting cream, the components are matched with each other, the synergistic effect is realized, the skin micro-ecology is focused, the unbalance of baby skin flora is adjusted from three dimensions of physics, chemistry and biology, the safety, the mildness and the no stimulation are realized, the bacterial infection can be effectively isolated, the stimulation of the outside to the skin is reduced, the balance of the baby skin surface flora is adjusted, the barrier capability of the baby skin is improved, the symptom of the baby 'red butt' is effectively improved, and the stability is good.

In the invention, the wheat germ extract is a glycerin solvent of the wheat (TRITICUM VULGARE) germ extract and also serves as a main skin conditioner, the wheat germ extract supplements natural nutrient components such as amino acid, mineral substances and oligosaccharide to the skin to help the skin to rebuild the structure, and the wheat germ extract can stimulate cell proliferation; thanks to the proteins, amino acids and sugars contained in the aqueous wheat solution, a barrier is formed on the skin, which protects the epidermis of the skin from external aggressions.

In the present invention, the skin conditioning agent comprises: bisabolol, wheat ceramide, phenytoin, antiallergic composition, Defushi, Terminalia catappa fruit extract and hydrolyzed wheat protein. The skin conditioner has the advantages that the components are matched with each other, the skin conditioner has a synergistic effect, can improve the barrier capability of the skin of the baby, adjust the colony balance of the skin of the baby, enhance the anti-inflammatory and anti-irritation capability of the skin, and has obvious effects on improving diaper rash, red rash and skin itch of the baby.

Wherein, the bisabolol and the xinmin shu (the ingredients of the xinmin shu comprise the bisabolol and the ginger (Zingiber officinale) root extract) are matched with each other to achieve synergistic effect, so that the bisabolol and the xinmin shu have excellent anti-inflammatory and bacteriostatic effects, can effectively relieve the stimulation of the outside to the skin, and can increase the anti-irritation and anti-inflammatory capabilities of the skin. Wheat ceramide, which is composed of glycolipid and glycosphingolipid, is derived from wheat grain extract, can reduce skin moisture loss, strengthen skin barrier by supplementing ceramide, which is intercellular colloid, rebuild dermis barrier by stimulating synthesis of collagenase inhibitor TIMP-1, strengthen dermis structure, and protect skin from oxidation pressure. The Defu lotion consists of hexyldecanol, bisabolol, cetyl N-palmitoyl hydroxyproline, stearic acid and rape (brassicacamphestris) sterol, has a structure similar to that of natural ceramide 2, can effectively improve the softness of the skin and enhance the barrier function of the skin, and also has a certain anti-inflammatory effect.

Preferably, the hip-care cream comprises the following components in percentage by mass: 5-25% of grease, 1-10% of skin conditioner, 0.5-5.0% of emulsifier, 0.5-2.5% of thickener, 8-25% of humectant and the balance of wheat germ extract.

In the present invention, the amount of the oil or fat added is 5 to 25%, for example, 5%, 6%, 7%, 8%, 9%, 10%, 12%, 14%, 16%, 18%, 20%, 21%, 23%, 25% or the like, based on 100% by mass of the total hip care cream.

In the present invention, the skin conditioner may be added in an amount of 1 to 10%, for example, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc., based on 100% by mass of the total hip care cream.

In the present invention, the amount of the emulsifier added is 0.5 to 5.0%, for example, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5.0%, etc., based on 100% by mass of the total hip care cream.

In the present invention, the thickener may be added in an amount of 0.5 to 2.5%, for example, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.1%, 2.3%, 2.5% or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the moisturizer added is 8 to 25%, for example, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25% or the like, based on 100% by mass of the total hip care cream.

Preferably, the skin conditioning agent comprises the following components in percentage by mass based on 100% of the total mass of the hip protecting cream: 0.05-0.3% of bisabolol, 0.001-0.5% of wheat ceramide, 0.05-0.3% of phenix, 0.5-3.0% of anti-allergy composition (DEFENSIL), 0.001-0.5% of Dekoujin, 0.01-0.5% of Terminalia faba fruit extract and 0.01-1.0% of hydrolyzed wheat protein.

In the present invention, the bisabolol may be added in an amount of 0.05 to 0.3%, for example, 0.05%, 0.06%, 0.08%, 0.1%, 0.12%, 0.14%, 0.16%, 0.18%, 0.2%, 0.22%, 0.24%, 0.26%, 0.28%, 0.3%, or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the wheat ceramide added may be 0.001 to 0.5%, for example, 0.001%, 0.005%, 0.01%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the soothing agent added is 0.05 to 0.3%, for example, 0.05%, 0.06%, 0.08%, 0.1%, 0.12%, 0.14%, 0.16%, 0.18%, 0.2%, 0.22%, 0.24%, 0.26%, 0.28%, 0.3% or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the desensitizing composition (DEFENSIL) added is 0.5 to 3.0%, for example, 0.5%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, 3.0%, or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the skin conditioner added is 0.001 to 0.5%, for example, 0.001%, 0.005%, 0.01%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5% or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the terminalia faba fruit extract added is 0.01 to 0.5%, for example, 0.01%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5% or the like, based on 100% by mass of the total hip care cream.

In the present invention, the amount of the hydrolyzed wheat protein added may be 0.01 to 1.0%, for example, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% or the like, based on 100% by mass of the total hip care cream.

Preferably, the anti-sensitivity composition comprises: sunflower seed oil unsaponifiable matter, extract of flowers/leaves/vines of the plant, echium oil, octyldodecanol and tocopherol. The antiallergic composition is DEFENSIS, which is composed of seed oil unsaponifiable matter of sunflower (Helianthus ANNUUS), flower/leaf/vine extract of Ardisia japonica (Cardiospermum halicaceum), seed oil of Echium PLANTAGINEUM (Echium planginanum), octyldodecanol and tocopherol, and is effective in reducing skin reaction to external irritation and relieving skin allergy. Wherein the extract of flowers/leaves/stems of Ardisia japonica (Cardiospermum halicaceum) contains phytosterols capable of reducing inflammation and allergic reaction to achieve skin soothing effect, wherein the extract of flowers/leaves/stems of Ardisia japonica is selected from any one or a combination of at least two of the extracts of flowers, leaves and stems of Ardisia japonica; echium planicatum (Echium planginanum) seed oil can reduce inflammation process, protect and strengthen skin barrier by inhibiting 5-lipoxygenase; the unsaponifiable sunflower (Helianthus ANNUUS) seed oil is an effective skin care active ingredient and can strengthen the skin barrier.

Preferably, the skin conditioner further comprises a plant composition.

Preferably, the plant composition is added in an amount of 0.02 to 0.08%, for example, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, etc., based on 100% by mass of the total hip care cream.

Preferably, the plant composition comprises: citrus extract, neroli extract, freesia extract, and magnolia extract. The plant composition is an antichidine plant composition, and comprises Citrus RETICULATA (Citrus RETICULATA) extract, Citrus AURANTIUM (Citrus AURANTIUM Amara) flower extract, herba Xanthii (FREESIA REFRACTA) extract, and flos Magnoliae (Magnolia DENUDATA) flower extract. The citrus extract has strong broad-spectrum antibacterial property, has the effect of eliminating various free radicals, and has the proliferation effect on epidermal fibroblasts. The extract of Citrus aurantium has antioxidant, antiinflammatory, and antibacterial effects, and can promote cell regeneration and enhance cell activity. The litsea cubeba extract has sufficient moisture to the skin and enhances the moisture retention and water locking functions. The Magnolia extract has effect in inhibiting common dermatophytes. The antioxidant plant composition components are synergistically matched with other components in the skin conditioner, so that the infant skin colony balance is further adjusted, and the anti-inflammatory and anti-irritation capability of the skin is enhanced.

Preferably, panthenol is further included in the skin conditioning agent.

The amount of panthenol added is preferably 0.1 to 1.0%, for example, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, or the like, based on 100% by mass of the total hip care cream.

Preferably, the skin conditioning agent further comprises urea.

Preferably, the urea is added in an amount of 2.0 to 5.0%, for example, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, 3.0%, 3.2%, 3.4%, 3.6%, 3.8%, 4.0%, 4.2%, 4.4%, 4.6%, 4.8%, 5.0%, etc., based on 100% by mass of the hip care cream.

Preferably, the oil or fat comprises any one of caprylic/capric triglyceride, shea butter, cetyl ethylhexanoate, coconut oil or dimethicone or a combination of at least two thereof. The skin is moistened with oils and fats such as coconut (Cocos NUCIFERA) oil and Butyrospermum PARKII (Butyripermum PARKII) fat.

Preferably, the emulsifier comprises cetyl dimethicone and/or sorbitan sesquioleate.

Preferably, the thickening agent comprises beeswax and/or magnesium sulphate.

Preferably, the beeswax is beeswax N467. (the beeswax N467 component comprises hydrogenated rapeseed oil, hydrogenated coconut oil, microcrystalline wax, synthetic wax, and octyldodecanol.)

Preferably, the humectant comprises any one or a combination of at least two of glycerol, propylene glycol or 1, 2-hexanediol.

Preferably, the hip-care cream also comprises an antibacterial agent.

Preferably, the antimicrobial agent is added in an amount of 2.0 to 6.0%, for example, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, 3.0%, 3.2%, 3.4%, 3.6%, 3.8%, 4.0%, 4.2%, 4.4%, 4.6%, 4.8%, 5.0%, 5.5%, 6.0%, etc., based on 100% by mass of the total hip care cream.

Preferably, the antimicrobial agent is zinc oxide; the antibacterial effect is achieved from physical dimension, the antibacterial component is an effective antibacterial component, and is used together with a skin conditioner without adding an additional preservative, so that the growth of microorganisms in a formula can be inhibited, and meanwhile, the antibacterial and skin-conditioning agent has the effects of partial bacteriostasis, drying and convergence on the bracts.

Preferably, the hip-care cream further comprises an antioxidant.

Preferably, the antioxidant is added in an amount of 0.1 to 2.0%, for example, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, etc., based on 100% by mass of the total hip care cream.

Preferably, the antioxidant comprises tocopherol and/or p-hydroxyacetophenone.

Preferably, the hip-care cream further comprises a chelating agent.

Preferably, the chelating agent is added in an amount of 0.03 to 0.1%, for example, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, etc., based on 100% by mass of the total hip care cream.

Preferably, the chelating agent is disodium EDTA.

Preferably, the hip-care cream comprises the following components in percentage by mass: caprylic/capric triglyceride 2.0-8.0%, shea butter 0.5-4.0%, cetyl ethyl hexanoate 2.0-8.0%, coconut oil 1.0-5.0%, polydimethylsiloxane 1.0-3.0%, bisabolol 0.05-0.3%, wheat ceramide 0.001-0.5%, phenytoin 0.05-0.3%, antiallergic composition 0.5-3.0%, dermatan 0.001-0.5%, Terminalia faba fruit extract 0.01-0.5%, hydrolyzed wheat protein 0.01-1.0%, plant composition 0.02-0.08%, panthenol 0.1-1.0%, urea 2.0-5.0%, cetyl/PEG-10/1 polydimethylsiloxane 1.0-3.0%, sorbitan sesquioleate 0.5-1.5%, beeswax 4670.5-1.5%, magnesium sulfate 0.5-1.5%, glycerol 0.8-18.0%, 18.8-18% >, and other adjuvants, 3.0-8.0% of propylene glycol, 0.4-1.5% of 1, 2-hexanediol, 2.0-6.0% of zinc oxide, 0.1-1.0% of tocopherol, 0.001-0.5% of p-hydroxyacetophenone, 0.03-0.1% of EDTA disodium and the balance of wheat germ extract.

In a second aspect, the present invention provides a preparation method of the baby wheat fresh extract raw pulp hip-protecting cream according to the first aspect, wherein the preparation method of the hip-protecting cream comprises the following steps:

(1) mixing oil, an emulsifier and a thickener to obtain an oil phase mixed solution; mixing wheat germ extract and humectant with water phase to obtain water phase mixture;

(2) adding the water phase mixed solution obtained in the step (1) into the oil phase mixed solution, and mixing and stirring to obtain emulsion;

(3) and (3) adding a skin conditioner into the emulsion obtained in the step (2), mixing, homogenizing, and defoaming in vacuum to obtain the baby wheat fresh extract protoplasm hip-protecting cream.

Preferably, the temperature of the oil phase mixture is 80-85 ℃, for example, 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃ and the like.

Preferably, in step (1), the oil phase is mixed for 10-20min, such as 10min, 11min, 12min, 13min, 14min, 15min, 16min, 17min, 18min, 19min, 20min, etc.

Preferably, in the step (1), the temperature of the aqueous phase mixing is 85 to 90 ℃, for example, 85 ℃, 86 ℃, 87 ℃, 88 ℃, 89 ℃, 90 ℃ and the like,

preferably, in step (1), the time for mixing the oil phase is 10-15min, for example, 10min, 11min, 12min, 13min, 14min, 15min, etc.

Preferably, in the step (2), the temperature of the mixing and stirring is 80 to 82 ℃, for example, 80 ℃, 81 ℃, 82 ℃ and the like can be used.

Preferably, in step (3), the temperature for mixing with the skin conditioner is 60 ℃ or less, for example, 10 ℃, 15 ℃, 20 ℃, 25 ℃, 30 ℃, 35 ℃, 40 ℃, 45 ℃, 50 ℃, 55 ℃, 60 ℃, preferably 45 ℃ or less.

Preferably, in step (3), the homogenization time is 30-60s, such as 30s, 35s, 40s, 45s, 50s, 55s, 60s, and the like.

Preferably, the preparation method of the hip-care cream comprises the following steps:

(1) stirring and mixing oil, emulsifier, thickener, antioxidant and antibacterial agent at 80-85 deg.C for 10-20min to obtain oil phase mixed solution; mixing wheat germ extract, humectant and chelating agent at 85-90 deg.C under stirring for 10-15min to obtain water phase mixed solution;

(2) adding the water phase mixed solution obtained in the step (1) into the oil phase mixed solution, and mixing and stirring at 80-82 ℃ to obtain emulsion;

(3) and (3) cooling the emulsion obtained in the step (2) to below 45 ℃, adding a skin conditioner, mixing, homogenizing for 30-60s, and defoaming in vacuum to obtain the baby wheat fresh extract protoplasm hip-protecting cream.

Compared with the prior art, the invention has the following beneficial effects:

the baby wheat fresh extract protoplasm hip-protecting cream is safe, mild and non-irritating, is free of mineral oil petrolatum, essence and preservatives, has efficient and allergy-relieving components, improves the barrier capability of baby skin, adjusts the colony balance of the baby skin, enhances the anti-inflammatory and anti-irritation capability of the skin, and has obvious effects of improving baby diaper rash, red rash and skin pruritus.

Detailed Description

The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.

The components in the following examples were obtained from the following manufacturers: wheat germ extract (Australian origin), wheat ceramide (DE-As), Jasmine (DE-As), DEFENSIL anti-allergy composition (DE-As), Defushi (DE-As), Fadens Terminalia seed fruit extract (Australian origin), hydrolyzed wheat protein (DE-As), ANTIOXIDISE plant composition (Guangzhou vast), caprylic/capric triglyceride (Olean), cetyl PEG/PPG-10/1 polydimethylsiloxane (Olean), and other materials are commercially available.

Example 1

The embodiment provides a baby wheat fresh extract raw pulp hip-protecting cream which comprises the following components in percentage by mass:

the preparation method of the hip-care cream provided by the embodiment comprises the following steps:

(1) stirring and mixing the grease, the emulsifier, the thickener, the antioxidant and the antibacterial agent for 15min at 82 ℃ to obtain an oil phase mixed solution; mixing wheat germ extract, humectant and chelating agent at 87 deg.C under stirring for 12min to obtain water phase mixed solution;

(2) adding the water phase mixed solution obtained in the step (1) into the oil phase mixed solution, and mixing and stirring at 81 ℃ to obtain emulsion;

(3) and (3) cooling the emulsion obtained in the step (2) to 35 ℃, adding a skin conditioner, mixing, homogenizing for 40s, and performing vacuum defoaming to obtain the infant wheat fresh extract protoplasm hip-protecting cream.

Example 2

(1) stirring and mixing the grease, the emulsifier, the thickener, the antioxidant and the antibacterial agent at 85 ℃ for 20min to obtain an oil phase mixed solution; mixing wheat germ extract, humectant and chelating agent at 90 deg.C under stirring for 10min to obtain water phase mixed solution;

(2) adding the water phase mixed solution obtained in the step (1) into the oil phase mixed solution, and mixing and stirring at 80 ℃ to obtain emulsion;

(3) and (3) cooling the emulsion obtained in the step (2) to 45 ℃, adding a skin conditioner, mixing, homogenizing for 60s, and performing vacuum defoaming to obtain the infant wheat fresh extract raw stock hip-protecting cream.

Example 3

(1) stirring and mixing the grease, the emulsifier, the thickener, the antioxidant and the antibacterial agent at 80 ℃ for 10min to obtain an oil phase mixed solution; mixing wheat germ extract, humectant and chelating agent at 95 deg.C under stirring for 15min to obtain water phase mixed solution;

(2) adding the water phase mixed solution obtained in the step (1) into the oil phase mixed solution, and mixing and stirring at 82 ℃ to obtain emulsion;

(3) and (3) cooling the emulsion obtained in the step (2) to 25 ℃, adding a skin conditioner, mixing, homogenizing for 30s, and performing vacuum defoaming to obtain the infant wheat fresh extract raw stock hip-protecting cream.

Example 4

The embodiment provides a baby wheat fresh extract protoplasm hip-protecting cream which is different from the embodiment 1 only in that no antibacterial agent zinc oxide is added, the contents of other components except for a wheat germ extract are the same as those in the embodiment 1, the wheat germ extract is supplemented to 100%, and the preparation method is the same as that in the embodiment 1.

Example 5

The embodiment provides a baby wheat fresh extract protoplasm hip-protecting cream, which is different from the embodiment 1 only in that the anti-bodiise plant composition is not added into the skin conditioner, the contents of other components except for the wheat germ extract are the same as the embodiment 1, the wheat germ extract is supplemented to 100 percent, and the preparation method is the same as the embodiment 1.

Example 6

The embodiment provides a baby wheat fresh extract protoplasm hip-protecting cream which is different from the embodiment 1 only in that panthenol is not added into a skin conditioner, the contents of other components except for a wheat germ extract are the same as that in the embodiment 1, the wheat germ extract is supplemented to 100%, and the preparation method is the same as that in the embodiment 1.

Example 7

The embodiment provides a baby wheat fresh extract protoplasm hip-protecting cream which is different from the embodiment 1 only in that urea is not added into a skin conditioner, the content of other components except for a wheat germ extract is the same as that in the embodiment 1, the wheat germ extract is supplemented to 100%, and the preparation method is the same as that in the embodiment 1.

Example 8

The embodiment provides a baby wheat fresh extract raw stock hip-protecting cream which is different from the cream in the embodiment 1 only in that the fat is not added with shea butter, the content of coconut oil is increased to 5.0 percent, and the content of other components and the preparation method are the same as the embodiment 1.

Comparative example 1

This comparative example provides a baby wheat fresh extract raw stock hip-care cream, which differs from example 1 only in that no bisabolol is added to the skin conditioner, the ceramide content of wheat is increased to 0.12%, the phenytoin content is increased to 0.18%, the DEFENSIS anti-allergy composition content is increased to 2.02%, the dermatan content is increased to 0.12%, the Terminalia faba fruit extract content is increased to 0.04%, the hydrolyzed wheat protein content is increased to 0.03%, the ANTIOXIDISE plant composition content is increased to 0.06%, the panthenol content is increased to 0.52%, the urea content is increased to 3.02%, and the other component contents and preparation methods are the same as example 1.

Comparative example 2

This comparative example provides a baby wheat fresh extract raw stock hip-care cream, which differs from example 1 only in that no wheat ceramide is added to the skin conditioner, the bisabolol content is increased to 0.21%, the phenytoin content is increased to 0.16%, the defenseil anti-allergy composition content is increased to 2.01%, the dermaphyllum content is increased to 0.11%, the terminalia faba fruit extract content is increased to 0.02%, the hydrolyzed wheat protein content is increased to 0.02%, the antioxidie plant composition content is increased to 0.05%, the panthenol content is increased to 0.52%, the urea content is increased to 3.01%, and the other component contents and preparation method are the same as example 1.

Comparative example 3

The comparative example provides a baby wheat fresh extract raw stock hip-protecting cream, which is different from the cream in the example 1 only in that the skin conditioner is not added with indomethacin, the content of bisabolol is increased to 0.255%, the content of wheat ceramide is increased to 0.115%, the content of DEFENSIS anti-allergy composition is increased to 2.015%, the content of Dekochia scoparia is increased to 0.115%, the content of Terminalia faba fruit extract is increased to 0.025%, the content of hydrolyzed wheat protein is increased to 0.025%, the content of ANTIOXIDISE plant composition is increased to 0.055%, the content of panthenol is increased to 0.515%, the content of urea is increased to 3.015%, and the content of other components and the preparation method are the same as the example 1.

Comparative example 4

This comparative example provides a baby wheat fresh extract raw stock hip-care cream, which differs from example 1 only in that no DEFENSIL antiallergic composition is added to the skin conditioner, the bisabolol content is increased to 0.4%, the wheat ceramide content is increased to 0.5%, the phenytoin content is increased to 0.35%, the Dekochia scoparia content is increased to 0.3%, the Terminalia faba fruit extract content is increased to 0.21%, the hydrolyzed wheat protein content is increased to 0.21%, the ANTIOXIDISE plant composition content is increased to 0.24%, the panthenol content is increased to 0.7%, the urea content is increased to 3.2%, and the other components and preparation method are the same as example 1.

Comparative example 5

This comparative example provides a baby wheat fresh extract raw stock hip-care cream, which differs from example 1 only in that no dermabrasion is added to the skin conditioner, the bisabolol content is increased to 0.21%, the wheat ceramide content is increased to 0.12%, the phenytoin content is increased to 0.16%, the defensesil antiallergic composition content is increased to 2.01%, the terminalia faba fruit extract content is increased to 0.02%, the hydrolyzed wheat protein content is increased to 0.02%, the antioxidie plant composition content is increased to 0.05%, the panthenol content is increased to 0.51%, the urea content is increased to 3.01%, and the other components are contained and prepared in the same manner as in example 1.

Comparative example 6

The comparative example provides a baby wheat fresh extract protoplasm hip-protecting cream, which is different from the cream in example 1 only in that the skin conditioner is not added with the terminalia catappa fruit extract, the content of other components except the wheat germ extract is the same as that in example 1, the wheat germ extract is supplemented to 100 percent, and the preparation method is the same as that in example 1.

Comparative example 7

The comparative example provides a baby wheat fresh extract protoplasm hip-protecting cream, which is different from the example 1 only in that hydrolyzed wheat protein is not added into a skin conditioner, the contents of other components except for a wheat germ extract are the same as the example 1, the wheat germ extract is supplemented to 100 percent, and the preparation method is the same as the example 1.

Test example 1

Patch test

Randomly selecting 30 children of 2-5 years old, wherein the children comprise 12 boys and 18 girls, and the test substances are infant wheat fresh extract raw stock hip-protecting cream prepared in examples 1-8 and infant wheat fresh extract raw stock hip-protecting cream prepared in comparative examples 1-8. The negative control was a blank control. In the closed spot test method, about 0.02g of the test substance is coated in a spot device, an external medical adhesive tape is pasted on the bent side of the forearm of the testee, the test substance is removed within 24h, the skin reaction is observed within 0.5h, 24h and 48h of the spot test respectively, the skin reaction grading standard in the cosmetic hygiene specification (2015 edition) is shown in table 1, and the test result is shown in table 2.

TABLE 1

Grade	Symbol	Identification criteria
			0	-	Negative reaction: has no irritation and erythema
1	±	And (3) suspicious reaction: mild erythema
			2	+	Weak positive reaction: erythema
3	++	Strong positive reaction: erythema, papules, blisters
			4	+++	Extremely strong positive reaction: severe edema and blisters

TABLE 2

The skin patch test results in table 2 show that the baby wheat fresh extract raw stock hip-protecting cream disclosed by the invention is 0-level reaction, namely no irritation and no erythema, and compared with examples 1-8, the effects are slightly reduced because the wheat germ extract and the skin conditioner are matched with each other, so that the synergy is realized, the skin irritation can be further relieved, and the skin tolerance is enhanced. The lack of either component proved to be insufficient for the desired regulation. Meanwhile, the components in the composition and the cosmetics provided by the invention are safe, mild and non-irritant. The hip-protecting cream provided by the invention is scientific and reasonable in compatibility, can obviously reduce toxic and side effects and irritation after synergistic interaction, and can be proved to cause no adverse reaction on children skin.

Test example 2

Stability test

The test substance is the baby wheat fresh extract raw stock hip-protecting cream prepared in the examples 1-8, the baby wheat fresh extract raw stock hip-protecting cream prepared in the examples is sampled according to the national standard of GBT34857-2017, the samples are packaged in a transparent cosmetic bottle and a test sample bottle, the transparent cosmetic bottle and the test sample bottle are respectively placed under the experimental conditions of-18 ℃, 25 ℃, 45 ℃ and 48 ℃, the continuous test of the appearance, the fragrance, the pH value, the viscosity and other items is carried out for 30 days, and the phenomena of bad phenomena such as bleeding, layering, separation, precipitation, discoloration, peculiar smell, demulsification and the like are observed. Specific test results are shown in table 3.

TABLE 3

The above test results show that: examples the infant wheat fresh extract raw stock hip cream prepared in examples 1-8 is a milky cream which is uniform, free of particles, good in stability, natural and light in smell, and good in stability, and can pass high and low temperature stability experiments, and the above adverse phenomena are not generated.

Test example 3

Histamine stimulation test

The experimental principle is as follows: histamine is produced from histidine under the action of a decarboxylase. Histamine is contained in large quantities in many tissues, particularly in mast cells of the skin, lung and intestinal mucosa. The hip cream is tested for its ability to alleviate inflammatory and allergic reactions by simulating the histamine irritation relief test, which releases histamine when tissue is damaged or inflammatory and allergic reactions occur.

The testing method comprises the steps of selecting 20 adults with skin health ages of 20-30 years and half of men and women, ensuring that the adults do not use any skin care product within 24 hours, cleaning arms, naturally airing, selecting a 2 × 2cm area at the front part of a wrist, coating 0.05mL of 5mg/mL histamine solution, completely absorbing, standing for 10min, coating the infant wheat fresh extract raw stock hip protection cream obtained in the embodiment of the invention on the left-hand testing part, coating the infant wheat fresh extract raw stock hip protection cream obtained in the comparative example on the right-hand testing part, observing and recording skin conditions under different times, wherein the skin state results are shown in a table 4, and the itching feeling is shown in a table 5:

scratchiness scoring standard: no itch: 0, mild itching: 1 point, general itching: score 2, comparative pruritus: score 3, intense itching: and 4, dividing.

TABLE 4

TABLE 5

As can be seen from the test data in tables 4 and 5, the baby wheat fresh extract raw stock hip-protecting cream prepared in examples 1 to 8 of the present invention can effectively alleviate skin itch, improve skin problems such as erythema and blisters, and has an excellent anti-histamine effect. The invention fully shows that the baby wheat fresh extract protoplasm hip-protecting cream has high-efficiency and allergy-relieving components, the components are mutually matched and synergized, the barrier capability of the skin of a baby can be improved, the colony balance of the skin of the baby is adjusted, the anti-inflammatory and anti-irritation capability of the skin is enhanced, and the baby wheat fresh extract protoplasm hip-protecting cream has obvious effects on improving diaper rash, red rash and skin itch of the baby.

Test example 4

Product efficacy testing

80 babies with diaper rash and the similar lightness and weight degrees and the ages of 0-2 are divided into 16 groups, 5 babies in each group are not smeared with any nursing product and medicine on the affected part within 24 hours, the fresh extracted infant wheat raw stock hip pad cream prepared in the examples 1-8 and the fresh extracted infant wheat raw stock hip pad cream prepared in the comparative examples 1-8 are respectively used, the affected part is smeared with the hip pad cream for 3 times every day, meanwhile, the diaper is replaced for 3 times every day, and the skin recovery condition of the babies is respectively observed by baby guardians.

Grading standard: health: score 0, erythema, sporadic papules: 0.1-1.0 points, erythema, small amounts of papules and blisters: 1.1-2.0 points, erythema, copious papules and blisters: 2.1-3.0, erythema, pustule, erosion: 3.0-4.0 min. The scoring data was averaged.

The specific test results are shown in table 6:

TABLE 6

As can be seen from the test data in table 6, the baby wheat fresh extract raw stock hip-care cream product prepared in the embodiments 1 to 8 of the present invention has excellent effects of alleviating and repairing baby diaper rash, and is fast in alleviating speed, good in effect, stable and not easy to relapse. While the hip cream products provided in comparative examples 1 to 8 had a slow rate of relief and poor results when any of the ingredients in the skin conditioner was determined, had some erythema, small amounts of pimples and blisters after 15 days of use, and were prone to the repeated appearance of erythema, pimples and blisters initially. The invention fully shows that the baby wheat fresh extract protoplasm hip-protecting cream has high-efficiency and allergy-relieving components, the components are mutually matched and synergized, the barrier capability of the skin of a baby can be improved, the colony balance of the skin of the baby is adjusted, the anti-inflammatory and anti-irritation capability of the skin is enhanced, and the baby wheat fresh extract protoplasm hip-protecting cream has obvious effects on improving diaper rash, red rash and skin itch of the baby.

The applicant states that the invention is described by the above examples to describe baby wheat fresh extract raw stock hip-protecting cream and the preparation method thereof, but the invention is not limited to the above examples, that is, the invention is not meant to be implemented only by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

Claims

1. The utility model provides a baby wheat fresh extract primary pulp hip-care cream which is characterized in that the hip-care cream comprises: wheat germ extract, skin conditioner, oil, emulsifier, thickener, humectant and chelating agent;

the skin conditioning agent comprises: bisabolol, wheat ceramide, phenytoin, antiallergic composition, Defushi, Terminalia catappa fruit extract and hydrolyzed wheat protein.

2. The infant wheat fresh extract raw stock hip-care cream as claimed in claim 1, wherein the hip-care cream comprises the following components in percentage by mass: 5-25% of grease, 1-10% of skin conditioner, 0.5-5.0% of emulsifier, 0.5-2.5% of thickener, 8-25% of humectant and the balance of wheat germ extract.

3. The baby wheat fresh extract protoplasm hip-protecting cream according to claim 1 or 2, characterized in that the skin conditioner comprises, based on 100% of the total mass of the hip-protecting cream: 0.05-0.3% of bisabolol, 0.001-0.5% of wheat ceramide, 0.05-0.3% of phenix, 0.5-3.0% of anti-allergy composition, 0.001-0.5% of dermaphyllum chinense, 0.01-0.5% of terminalia faba fruit extract and 0.01-1.0% of hydrolyzed wheat protein.

4. The infant wheat fresh extract stock hip cream according to any one of claims 1 to 3, wherein the anti-allergy composition comprises: sunflower seed oil unsaponifiable matter, extract of flowers/leaves/vines of the plant, echium oil, octyldodecanol and tocopherol;

preferably, the skin conditioner further comprises a plant composition;

preferably, the addition amount of the plant composition is 0.02-0.08% based on 100% of the total mass of the hip-care cream;

preferably, the plant composition comprises: citrus extract, neroli extract, freesia extract and magnolia extract;

preferably, panthenol is further included in the skin conditioning agent;

preferably, the addition amount of the panthenol is 0.1-1.0% based on 100% of the total mass of the hip care cream;

preferably, the skin conditioning agent further comprises urea;

preferably, the addition amount of the urea is 2.0-5.0% based on 100% of the total mass of the hip-care cream.

5. The infant wheat fresh extract puree hip cream according to any one of claims 1-4, wherein the oil comprises any one or a combination of at least two of caprylic/capric triglyceride, shea butter, cetyl ethylhexanoate, coconut oil, or dimethicone;

preferably, the emulsifier comprises cetyl dimethicone and/or sorbitan sesquioleate;

preferably, the thickening agent comprises beeswax and/or magnesium sulphate;

preferably, the beeswax is beeswax N467;

6. The baby wheat fresh extract protoplasm hip-care cream according to any one of claims 1 to 5, further comprising an antibacterial agent;

preferably, the addition amount of the antibacterial agent is 2.0-6.0% based on 100% of the total mass of the hip-protecting cream;

preferably, the antimicrobial agent is zinc oxide;

preferably, the hip-care cream further comprises an antioxidant;

preferably, the addition amount of the antioxidant is 0.1-2.0% based on 100% of the total mass of the hip-care cream;

preferably, the antioxidant comprises tocopherol and/or p-hydroxyacetophenone;

preferably, the hip-care cream also comprises an anti-chelating agent;

preferably, the addition amount of the chelating agent is 0.03-0.1% based on 100% of the total mass of the hip-care cream;

preferably, the chelating agent is disodium EDTA.

7. The baby wheat fresh extract protoplasm hip-care cream according to any one of claims 1 to 6, which comprises the following components in percentage by mass: caprylic/capric triglyceride 2.0-8.0%, shea butter 0.5-4.0%, cetyl ethyl hexanoate 2.0-8.0%, coconut oil 1.0-5.0%, polydimethylsiloxane 1.0-3.0%, bisabolol 0.05-0.3%, wheat ceramide 0.001-0.5%, phenytoin 0.05-0.3%, antiallergic composition 0.5-3.0%, dermatan 0.001-0.5%, Terminalia faba fruit extract 0.01-0.5%, hydrolyzed wheat protein 0.01-1.0%, plant composition 0.02-0.08%, panthenol 0.1-1.0%, urea 2.0-5.0%, cetyl/PEG-10/1 polydimethylsiloxane 1.0-3.0%, sorbitan sesquioleate 0.5-1.5%, beeswax 4670.5-1.5%, magnesium sulfate 0.5-1.5%, glycerol 0.8-18.0%, 18.8-18% >, and other adjuvants, 3.0-8.0% of propylene glycol, 0.4-1.5% of 1, 2-hexanediol, 2.0-6.0% of zinc oxide, 0.1-1.0% of tocopherol, 0.001-0.5% of p-hydroxyacetophenone, 0.03-0.1% of EDTA disodium and the balance of wheat germ extract.

8. The preparation method of the infant wheat fresh extract protoplasm hip-protecting cream according to any one of claims 1 to 7, wherein the preparation method of the hip-protecting cream comprises the following steps:

9. The method for preparing the oil-phase mixture of claim 8, wherein the temperature for mixing the oil phase in step (1) is 80-85 ℃;

preferably, in the step (1), the oil phase is mixed for 10-20 min;

preferably, in the step (1), the temperature for mixing the water phase is 85-90 ℃;

preferably, in the step (1), the oil phase is mixed for 10-15 min;

preferably, in the step (2), the temperature of the mixing and stirring is 80-82 ℃;

preferably, in the step (3), the temperature for mixing with the skin conditioner is below 60 ℃, preferably below 45 ℃;

preferably, in the step (3), the homogenization time is 30-60 s.

10. The method for preparing the hip care cream according to claim 9, wherein the method for preparing the hip care cream comprises the following steps:

(1) stirring and mixing the grease, the emulsifier and the thickener at 80-85 ℃ for 10-20min to obtain an oil phase mixed solution; mixing wheat germ extract, humectant and chelating agent at 85-90 deg.C under stirring for 10-15min to obtain water phase mixed solution;

(3) and (3) cooling the emulsion obtained in the step (2) to below 45 ℃, adding a skin conditioner, an antioxidant and an antibacterial agent, mixing, homogenizing for 30-60s, and performing vacuum defoaming to obtain the infant wheat fresh extract protoplasm hip-protecting cream.