CN112870223A - Infant hip-protecting composition - Google Patents

Abstract

The present invention relates to an infant hip care composition, in particular to an infant hip care composition comprising zinc oxide and D-panthenol.

Description

Infant hip-protecting composition

Technical Field

The present invention relates to an infant hip care composition, in particular to an infant hip care composition comprising zinc oxide and D-panthenol.

Background

The red buttocks of infants are also called diaper rash or diaper rash medically. Diaper rash occurs due to a number of factors: the skin cuticle of the infant is thin, and the endothelium contains more water and chloride and is easy to be allergic; the natural sebum protective film of the skin is damaged by stimulation such as frequent milk overflow, urine, paper diaper friction and the like; the hip skin is moist for a long time, the diaper is not breathable when being worn, and a large amount of germs are easy to breed on the surface of the skin when the diaper is used for a long time; the hip skin is often contacted with some cleaning solutions, the original beneficial flora balance of the skin of the baby is broken, and the protective effect of the skin mucosa is damaged due to flora disorder.

The baby hip-protecting cream in the prior art generally comprises chemical grease, talcum powder, essence, preservative and emulsifier, and has the effects of forming a protective film on the surface of skin and relieving the phenomenon of red buttocks, but has no functions of relieving and repairing damaged skin with the symptom of diaper rash.

For example;

1. high zinc oxide content pharmaceutical ointment: more specifically, the ointment is prepared by a water-free or basically water-free formula process, and vaseline is used as a main dispersing agent. Although the waterproof effect is good, the following defects exist: greasy, very difficult to clean after smearing; the paste is not stored at high temperature, and once the paste is liquefied at the storage temperature higher than the melting point of vaseline, suspended zinc oxide in the formula can be slowly precipitated and layered to cause quality problems, so the paste can be stored and transported only at room temperature; the water-soluble high-efficiency bacteriostatic agent (such as various salts of poly aminopropyl biguanide, poly hexamethylene biguanide, chlorhexidine, and the like) can not be added, and the bacteriostatic function can not be provided; the skin of the water-deficient chap cannot be supplemented with water.

Typical marketed products include:

the zinc oxide ointment (OTC medicine) is sold in the market by a plurality of families in China, and the formula is as follows: 15% zinc oxide, the balance of vaseline (and liquid paraffin);

② compound cod-liver oil zinc oxide ointment (OTC medicine) -sold in the market by a plurality of families in China, the formula is: 20% of zinc oxide, and the balance of cod liver oil 8%, nitrofural 0.1%, vaseline, lanolin, talcum powder and liquid paraffin;

③ Qiangsheng (J & J) purple Desitin hip-protecting ointment, the formula comprises 40 percent of zinc oxide, and the balance of vaseline, cod liver oil, sheep oil, talcum powder, glycerol, sorbitan sesquioleate, beeswax, tocopheryl acetate and essence.

Fourthly, baby's hip-protecting cream with the formula as follows: petrolatum, mineral oil, zinc oxide, paraffin, stearyl glycyrrhetinate, and polymethylsiloxane.

Fifthly, the flatus repairing ointment for the baby is prepared from the following components in parts by weight: petrolatum, zinc oxide, Indian vine seed fat, cassava starch, glycerol behenate, polyglycerol-6-octastearate, stearyl glycyrrhetinate, sunflower seed oil and tocopherol (vitamin E).

CN101507693B discloses a method for preparing a baby diaper cream, wherein the formula comprises 6-8% of zinc oxide, 47-51% of castor oil, 30-34% of sunflower seed oil, 6-8% of honey and 5.8-6.2% of auxiliary materials. The auxiliary materials comprise 1.8-2.2% of beta-sitosterol, 0.8-1.2% of marigold, 0.8-1.2% of linseed oil and 0.8-1.2% of soybean oil.

Seventhly, CN110302121A discloses a baby hip-protecting ointment and a preparation method thereof, and the formula is as follows: 60-90 parts of petrolatum, 5-15 parts of liquid paraffin, 3-8 parts of zinc oxide, 2-10 parts of microcrystalline wax, 2-10 parts of camellia seed oil, 1-5 parts of evening primrose oil, 0.1-1 part of antioxidant, 0.1-1 part of bisabolol, 0.01-1 part of olive fruit extract and 0.01-1 part of water.

2. Water-in-oil type hip cream: due to technical limitation, the high-content zinc oxide particles easily cause demulsification of a water-in-oil system under a heating or freeze-thawing state, so that only a zinc oxide formula without zinc oxide or with a low content is adopted, the using amount of the zinc oxide is hardly higher than 14.5%, and the astringency and anti-inflammation effects of the low-content zinc oxide are relatively poor; in addition, the formula and the process of the hip cream added with zinc oxide and D-panthenol are not reported in documents and disclosed in patents.

Typical marketed products include:

(1) the formula of the baby diaper cream (water-in-oil) contains water, mineral oil, 13% of zinc oxide, petrolatum, synthetic beeswax, polydimethylsiloxane, sorbitan sesquioleate, microcrystalline wax, PEG 30-dipolyhydroxystearate, magnesium sulfate, phenoxyethanol, 1, 2-hexanediol, octyl glycol, tocopheryl acetate, potassium hydroxide, glycerol, aloe vera leaf extract and tropolone.

(2) CN103690451B discloses a W/O hip cream for babies and children and a preparation method thereof, wherein the W/O hip cream comprises a component A, a component B and a component C, wherein the component A comprises 12-20% of grease, 3-5% of an emulsifier and 0.05-0.1% of an antioxidant in percentage by weight of the total weight of the hip cream; the component B comprises 65-80% of deionized water, 0.05-0.15% of allantoin, 3-5% of humectant and 0.5-0.8% of stabilizer by weight percentage; the component C comprises 0.3-0.8% of cortex moutan extract, 0.05-0.2% of rutin extract and 0.1-0.3% of sodium pyrrolidone carboxylate in percentage by weight of the total weight of the hip cream. The formulation does not contain zinc oxide.

(3) CN105997718B discloses a baby hip-care cream and a preparation method thereof, the formula is as follows: 6-10% of ethylhexyl palmitate, 0.8-2% of cetearyl alcohol, 0.3-0.8% of soybean oil, 2-6% of polydimethylsiloxane, 0.5-0.9% of stabilizer, 8-20% of humectant, 0.5-3% of surfactant, 0.1-0.3% of antioxidant, 2-6.5% of emulsifier, 0.5-2% of thickener, 0.05-0.5% of preservative, 0.8-2% of zinc oxide, 0.05-0.2% of bisabolol, 0.3-0.7% of lithospermum extract, 0.3-0.7% of argania spinosa kernel extract, 0.01-0.2% of essence, 0.1-0.5% of allantoin, 0.05-0.2% of disodium EDTA and 50-70% of water; the stabilizer is ethylhexyl isononanoate. Wherein the thickening agent is selected from sodium acrylate/sodium acryloyldimethyl taurate copolymer, is an anionic copolymer, and cannot be compatible with high-efficiency cationic polymer biguanide or guanidine bacteriostatic agent (various salts of polyaminopropyl biguanide, polyhexamethylene biguanide, chlorhexidine, and the like).

(4) CN104906553B discloses a water-in-oil infant hip cream and a preparation method thereof, and the formula is as follows: : deionized water, glycerol, diethylhexyl maleate, zinc oxide, butanediol, shea butter, 1, 2-pentanediol, tridecyl alcohol trimellitate, polydimethylsiloxane, cetyl PEG/PPG-10/1 polydimethylsiloxane, sodium lactate, C18-38 alcohol hydroxystearyl stearate, sorbitan sesquioleate, prinsepia utilis oil, bisabolol, ginger root extract, purslane extract, sodium hyaluronate, allantoin, tocopheryl acetate, polyhydroxystearic acid, dimethiconol, magnesium sulfate, and disodium EDTA.

(5) The hip cream on the market only contains D-panthenol (for example, the hip cream containing 4% of D-panthenol in German schba) has good coating feeling, but cannot prevent the skin of the baby from being polluted by excrement and germs at the same time. Has no astringent and anti-inflammatory effects of zinc oxide, and has relatively slow effect.

3. Oil-in-water type cream: although the oil-in-water type cream has good coating feeling, the cream cannot prevent water after being coated, so that the pollution of feces to the skin of a baby cannot be prevented and isolated, and the oil-in-water type cream is not suitable for the hip protection function in practice. In addition, the simple thickening emulsifier (various copolymers synthesized by acrylamide, acrylic acid or sodium salt, N-vinyl pyrrolidone and/or acryloyl dimethyl taurate and used for thickening and emulsifying) commonly used in the formula is an anionic polymer and is incompatible with cationic biguanide or guanidine (various salts of polyaminopropyl biguanide, polyhexamethylene biguanide, chlorhexidine and the like) disinfectants, and the formula cannot be added with the low-toxicity high-efficiency bacteriostatic agent, so the application is limited.

Disclosure of Invention

The invention relates to an infant hip care composition, which is characterized by comprising zinc oxide and D-panthenol which are anti-inflammatory and repair active ingredients.

Preferably, the composition of the present invention further comprises a complex emulsifier consisting of polyglyceryl-3-diisostearate, polyethylene glycol 30-dipolyhydroxystearate and squalane, the ratio between them being not strictly defined.

Preferably, the composition of the present invention further comprises a bacteriostatic agent selected from biguanides or cationic polymers of guanidines and/or phenoxyethanol.

Preferably, the composition is a water-in-oil composition, wherein the oil phase contains zinc oxide, the composite emulsifier, the bacteriostatic agent and common oil phase auxiliary materials, and the water phase contains D-panthenol, the bacteriostatic agent and common water phase auxiliary materials.

Preferably, the composition of the invention comprises in the oil phase:

white vaseline, a composite emulsifier, vitamin E acetate, phenoxyethanol, magnesium stearate and zinc oxide;

the composition comprises, in an aqueous phase:

d-panthenol, citric acid, allantoin, glycerol, polyhexamethylene biguanide (20%), water.

The infant hip care compositions of the present invention may be prepared according to conventional methods for preparing compositions in the art.

Detailed Description

The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.

Example 1

Oil phase:

10% of white vaseline, 5% of compound emulsifier, 0.2% of vitamin E acetate, 0.5% of phenoxyethanol, 0.5% of magnesium stearate and 15% of zinc oxide;

water phase:

1% of D-panthenol, 0.02% of citric acid, 0.1% of allantoin, 0.5% of glycerol, 0.1% of polyhexamethylene biguanide (20%) and 50% of water.

Example 2

Oil phase:

14% of white vaseline, 6% of compound emulsifier, 0.4% of vitamin E acetate, 0.5% of phenoxyethanol, 0.5% of magnesium stearate and 16.5% of zinc oxide;

water phase:

2% of D-panthenol, 0.02% of citric acid, 0.3% of allantoin, 0.5% of glycerol, 0.2% of polyhexamethylene biguanide (20%) and 55% of water.

Example 3

Oil phase:

18% of white vaseline, 7% of compound emulsifier, 0.6% of vitamin E acetate, 0.5% of phenoxyethanol, 0.5% of magnesium stearate and 18% of zinc oxide;

water phase:

3% of D-panthenol, 0.02% of citric acid, 0.5% of allantoin, 0.5% of glycerol, 0.3% of polyhexamethylene biguanide (20%) and 60% of water.

The following experiments show that the infant hip care composition has remarkable effects on red buttocks (red buttocks) of infants, has remarkable curative effects on miliaria, and has remarkable curative effects on eczema, pruritus, chap of dry skin and skin scratch.

(I) Experimental method

1 Effect observation on application of diaper rash (red buttocks)

1.1 data and methods

1.1.1 general data

In 40 cases, all the data are from newborn babies of baby diapers customers (consumers). The 40 newborns were randomized into 20 treatment groups and 20 control groups. Wherein the treatment group had 12 newborn males and 8 females; the age distribution is 1 month to 10 months, the average age is 5.2 months, the average weight is 10.3 kilograms, and the growth and development conditions are good. The age distribution of 10 newborn male and 10 newborn female in the control group is also 1 month to 10 months, the average age distribution is 5.3 months, the average body weight is 10.8 kg, and the growth condition is good. The general data difference between the two groups of neonates was not statistically significant and was comparable.

1.1.2 intervention methods

Two groups of neonates wear the same series of paper diapers (BBU free breathing paper diapers) of the same brand, the paper diapers are replaced for 1 time every 3 hours conventionally, and the replacement times can be increased properly when the stool and urine are too much. After the paper diaper is replaced each time, the BBU cotton soft towel is used for scrubbing the buttocks and drying and comfortable nursing of the buttocks are well performed. On the basis, the treatment group applies the infant hip-protecting cream produced by the method to the buttocks, and the infant hip-protecting cream is applied for 1 time after the diaper is replaced every time, and the dosage is about 1 g. The control group was treated with the same treatment group except that the infant hip cream was not used.

1.2 evaluation criteria for Red hip degree

Mild: bright red erythema with clear edge at diaper contact part

Medium: papules and blisters may appear on the erythema with little seepage on the surface

And (3) severe degree: erosion can occur, for example, pustules or abrasions can occur due to bacterial infection

Both groups of neonates evaluated the incidence of red hips two months after engaging in the activity.

1.3 data

The incidence of red buttocks in the two groups of newborns was compared and is shown in table 1.

Table 1: two groups of newborn red buttock incidence cases (%)

Group of	Number of examples	Is free of	Mild degree of	Of moderate degree	Severe degree	Incidence rate
							Treatment group	20	17(85)	2(10)	1(5)	0(0)	3(15)
Control group	20	8(40)	7(35)	4(20)	1(5)	12(60)

1.4 results

As can be seen from Table 1, the red hip incidence rate of the treated group is only 15% and is obviously lower than 60% of that of the control group through the observation of the red hip application effect of the infants for two months. In addition, the treatment group was also significantly less red than the control group. The prevention effect of the treatment group on the red hip is obviously better than that of the control group.

2 Observation of the application Effect of miliaria

2.1 data and methods

2.1.1 data

In 20 cases, all the data are from volunteers with rash. Among them, 8 men and 12 women. 6 cases above 18 years old, 14 cases below 18 years old, 6 cases between 1 month and 3 years old, 5 cases between 6 years old and 12 years old. The physical condition is good.

2.1.2 intervention methods

Applying a small amount of the composition to the affected part, and gently kneading for a moment; the medicine is taken three times a day, and is taken 5-8 times a day for patients with serious disease or chronic inflammation. The effect was observed after one week of use.

2.2 data

The usage of the patient with rash is shown in Table 2.

Table 2: sublingular disease patient condition (%)

Number of examples	Without effect	The effect is obvious	Recovery method	Incidence rate
					20	1(5)	5(25)	14(70)	19(95)

2.3 results

As can be seen from Table 2, after one week of application to the miliaria of the volunteers, 14 cases of treatment are cured, the cure rate is 70%, 5 cases of significant effect are achieved, and 25% of treatment effect is achieved, so that the composition has a significant effect on the patients with the miliaria.

Observation of the effects of eczema, itching, dry skin, chapping and scratching

3.1 data and methods

3.1.1 data

The data in this group were obtained from 20 volunteers. All the people are adults and have good physical condition.

3.1.2 intervention methods

Applying a small amount of the composition to the affected part, and gently kneading for a moment; the medicine is taken three times a day, and is taken 5-8 times a day for patients with serious disease or chronic inflammation. The effect was observed after one week of use.

3.2 data

Eczema, pruritus, dry and chapped skin, and skin scratch, see table 3.

Table 3: eczema, pruritus, chap of dry skin, and skin scratch patient use case (%)

Number of examples	Without effect	The effect is obvious	Recovery method	Incidence rate
					20	1(5)	6(30)	13(65)	19(95)

3.3 results

As can be seen from Table 3, after one week of application to the sudoriferous eruptions of patients, 13 cases are cured, the cure rate is 65%, 6 cases with obvious effect reach 30%, and the composition has obvious effect on patients with eczema, pruritus, dry skin, chap and skin scratch.

(II) conclusion

Experiments show that the water-in-oil type infant hip pad composition has remarkable nursing and rehabilitation effects on infant hip redness and miliaria, and also has certain nursing and rehabilitation effects on chapping, pruritus, eczema and skin scratch of adults due to dry skin.

The above-described infant hip care composition is described for infants, and is also applicable to hip care for incontinent persons and elderly persons.

It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All the obvious contents of the technical scheme of the invention are all within the protection scope of the invention.

Claims (5)

1. An infant hip care composition characterized in that it comprises zinc oxide and D-panthenol as anti-inflammatory and restorative active ingredients.

2. The composition according to claim 1, characterized in that it further comprises a complex emulsifier consisting of polyglycerol-3-diisostearate, polyethylene glycol 30-dipolyhydroxystearate and squalane.

3. The composition according to claim 1, characterized in that it further comprises a bacteriostatic agent selected from biguanides or cationic polymers of guanidines and/or phenoxyethanol.

4. A composition according to any one of claims 1 to 3, characterized in that the composition is a water-in-oil composition, wherein the oil phase comprises zinc oxide, the complex emulsifier of claim 2, the bacteriostatic agent of claim 3 and customary oil phase excipients, and the aqueous phase comprises D-panthenol, the bacteriostatic agent of claim 3 and customary aqueous phase excipients.

5. Composition according to claim 4, characterized in that it comprises, in the oil phase:

white vaseline, the composite emulsifier, vitamin E acetate, phenoxyethanol, magnesium stearate and zinc oxide;

the composition comprises, in an aqueous phase:

d-panthenol, citric acid, allantoin, glycerol, polyhexamethylene biguanide (20%), water.