CN105997718A - Infant hip care cream and preparation method thereof - Google Patents
Infant hip care cream and preparation method thereof Download PDFInfo
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- CN105997718A CN105997718A CN201610537302.1A CN201610537302A CN105997718A CN 105997718 A CN105997718 A CN 105997718A CN 201610537302 A CN201610537302 A CN 201610537302A CN 105997718 A CN105997718 A CN 105997718A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention belongs to the field of skin care products and particularly relates to infant hip care cream and a preparation method thereof. The infant hip care cream is prepared from, by mass, ethylhexyl palmitate, cetostearyl alcohol, soybean oil, polydimethylsiloxane, a stabilizer, a moisturizing agent, a surface active agent, an antioxidant, an emulsifier, a thickener, a preservative, zinc oxide, bisabolol, a radix arnebiae extract, an argania spinosa extract, essence, allantoin, EDTA disodium salt and water. The infant hip care cream is safe and non-irritant, can effectively isolate bacterial infection and keep skin white, tender and smooth and meanwhile has excellent high and low temperature stability.
Description
Technical field
The invention belongs to skin care field, be specifically related to a kind of baby's diaper ointment and preparation method thereof.
Background technology
The red hip of baby are medically also known as " diaper rash " or " diaper rash ".Occur diaper rash because of
Element also has a lot: baby's keratodermatitis is thin, and endothelium is aqueous and chloride is more, easy allergy；Often overflow
Milk, urine, diaper friction etc. stimulate, and destroy the sebum protecting film that skin is natural；When skin of buttock is long
Between moist, wear airtight and life-time service diaper, easily cause pathogenic bacteria at skin surface amount reproduction；Buttocks
Portion's skin, often in contact with some cleaning solutions, breaks baby's skin original profitable strain balance, and Flora Disturbance is led
The protective effect causing skin mucosa is destroyed.
Existing baby's diaper ointment is typically by chemicals oils and fats, Pulvis Talci, essence, preservative, emulsifying agent
Composition, its effect is to form protecting film, the appearance of " red hip " phenomenon of releiving at skin surface, but it is to
The effect that the damaged skin of " diaper rash " symptom is not releived and repaired occurs.
Chinese patent application 201210473764.3 discloses a kind of infant hip protection gel, by following percent mass
The raw material of ratio is made: propylene glycol 4-6%, Radix Arnebiae (Radix Lithospermi) extract 3-5%, Acacia farnesiana Willd. berry extract 3-5%,
EDETATE SODIUM 0.04-0.06%, carbomer sodium 0.4-0.6%, Melaleuca alternifolia leaf oil 0.01-0.03%,
Bis(hydroxymethyl)imidazolidinyl urea 0.3-0.5%, remaining is deionized water.This invention infant hip protection gel has
There are moist moisturizing, the effect of sensitive skin of releiving, can effectively prevent baby buttocks pachylosis, cracking, especially
Its damaged skin being suitable for " diaper rash " symptom occurred, baby uses safe, non-stimulated.But this baby
The stability of hip protection gel is undesirable.
Summary of the invention
In order to solve technical problem present in prior art, the present invention provides a kind of baby's hip pad
Cream and preparation method thereof, it is safe and non-stimulating, can be effectively isolated antibacterial and infect, and keeps skin delicate bright and clean,
There is the high/low temperature stability of excellence simultaneously.
The invention provides a kind of baby's diaper ointment, including the component of following mass percent: Palmic acid second
The own ester of base 6～10%, cetearyl alcohol 0.8～2%, soybean oil 0.3～0.8%, polydimethylsiloxane 2～6%,
Stabilizer 0.5-0.9%, wetting agent 8～20%, surfactant 0.5～3%, antioxidant 0.1～0.3%,
Emulsifying agent 2～6.5%, thickening agent 0.5～2%, preservative 0.05～0.5%, zinc oxide 0.8～2%, opopanax
Alcohol 0.05～0.2%, Radix Arnebiae extract 0.3～0.7%, thorn A Gan tree core extract 0.3～0.7%, essence
0.01～0.2%, allantoin 0.1-0.5%, EDETATE SODIUM 0.05-0.2% and water 50～70%.
Preferably, described baby's diaper ointment includes the component of following mass percent: ethylhexyl palmitate
10%, cetearyl alcohol 1%, soybean oil 0.3%, polydimethylsiloxane 6%, stabilizer 0.9%, guarantor
Humectant 15%, surfactant 0.5%, antioxidant 0.3%, emulsifying agent 5%, thickening agent 0.5%, anti-
Rotten agent 0.5%, zinc oxide 0.8%, bisabolol 0.05%, Radix Arnebiae extract 0.3%, thorn A Gan tree core carry
Take thing 0.3%, essence 0.1%, allantoin 0.3%, EDETATE SODIUM 0.05% and water 50%.
Preferably, described baby's diaper ointment includes the component of following mass percent: ethylhexyl palmitate
6%, cetearyl alcohol 0.8%, soybean oil 0.5%, polydimethylsiloxane 2%, stabilizer 0.5%, guarantor
Humectant 8%, surfactant 1%, antioxidant 0.2%, emulsifying agent 2%, thickening agent 1%, preservative
0.2%, zinc oxide 1%, bisabolol 0.1%, Radix Arnebiae extract 0.5%, thorn A Gan tree core extract 0.4%,
Essence 0.01%, allantoin 0.1%, EDETATE SODIUM 0.1% and water 60%.
Preferably, described baby's diaper ointment includes the component of following mass percent: ethylhexyl palmitate
8%, cetearyl alcohol 2%, soybean oil 0.8%, polydimethylsiloxane 4%, stabilizer 0.7%, moisturizing
Agent 20%, surfactant 3%, antioxidant 0.1%, emulsifying agent 6.5%, thickening agent 2%, preservative
0.05%, zinc oxide 2%, bisabolol 0.2%, Radix Arnebiae extract 0.7%, thorn A Gan tree core extract 0.7%,
Essence 0.2%, allantoin 0.5%, EDETATE SODIUM 0.2% and water 50%.
Preferably, described wetting agent is selected from glycerol and/or propylene glycol.
Preferably, described wetting agent by glycerol and propylene glycol by 1:(0.3～1) weight ratio form.
Preferably, described antioxidant is tocopherol acetas.
Preferably, described emulsifying agent is selected from PEG-100 stearate, glyceryl stearate, stearic acid and three
The combination of one or more in ethanolamine.
Preferably, described emulsifying agent is by PEG-100 stearate, glyceryl stearate, stearic acid and three second
Hydramine presses 1:(0.5～1): (1～4): the weight ratio composition of (0.05～2).
Preferably, described preservative is selected from methyl hydroxybenzoate and/or phenyl phenol.
Preferably, described preservative is pressed (0.05～0.2) by methyl hydroxybenzoate and phenyl phenol: the weight of (0.05～0.2)
Amount is than composition.
Preferably, described stabilizer is different n-nonanoic acid Octyl Nitrite.
Preferably, described thickening agent is selected from sodium acrylate/sodium acryloyldimethyl taurate copolymers and/or Huang
Virgin rubber.
Preferably, described thickening agent is by sodium acrylate/sodium acryloyldimethyl taurate copolymers and xanthan gum
By (0.5～0.9): the weight ratio composition of (0.3～0.5).
Preferably, described surfactant by cetearyl glucoside and lauryl alcohol phosphate ester potassium by 1:
The weight ratio composition of (0.8～1).
Correspondingly, present invention also offers a kind of method preparing above-mentioned baby's diaper ointment, including following step
Rapid:
A) zinc oxide, ethylhexyl palmitate, soybean oil, antioxidant and bisabolol are taken in colloid mill
Upper grinding 3-5 time, crosses 180 mesh sieves, obtains material I, standby；
B) cetearyl alcohol, surfactant, emulsifying agent, polydimethylsiloxane and stabilizer are added
In oil phase pot, it is heated to 80～85 DEG C, stirring, until being completely dissolved, obtain material II, standby；
C) water, wetting agent, thickening agent, allantoin and EDETATE SODIUM are added in main cooker, homogenizing 3～5min,
It is allowed to be uniformly dispersed, is heated to 80-85 DEG C while stirring, be incubated 10 minutes；
D) by material II suction main cooker, homogenizing 4～8min, continuously add material I, homogenizing 3～5min,
Evacuation, insulation 15～30min after be cooled to 45 DEG C, add Radix Arnebiae extract, thorn A Gan tree core extract,
Preservative and essence, stirring is to mix homogeneously；
E) sampling Detection, filters discharging after the assay was approved.
In the present invention zinc oxide can the most waterproof, isolation, restrain skin, and extend effective antibacterial time；
Radix Arnebiae extract and bisabolol have hemostasis, antiinflammatory, restrain, moisten and promote the effect such as skin regeneration；Thorn
A Gan tree core extract has effect of moisturizing, nourishing and calmness to skin, and zinc oxide can be brought
Skin stimulates and effectively alleviates；Ethylhexyl palmitate, improves the permeability of effective ingredient；Add steady
Determine agent and surfactant, solve the technical problem that unguentum easily separates out at low temperature, improve the steady of diaper ointment
Qualitative；Utilize soybean oil and polydimethylsiloxane to form protecting film at skin surface, reduce zinc oxide to baby
The stimulation of youngster's skin；Xanthan gum and the compounding of sodium acrylate/sodium acryloyldimethyl taurate copolymers is selected to make
With, make diaper ointment be prone to be coated with exhibition and the viscosity of diaper ointment can be kept, after smearing, be difficult to trickling.The present invention
Can gentle effective isolation antibacterial injury, keep skin bright and clean, there is good antiinflammatory, Shu Minzuo simultaneously
With, gentle can moisten moisturizing, alleviate and stimulate, improve skin resistance, safely and effectively treat baby diaper
Rash, has stability high, the advantage that permeability is high simultaneously.
Compared with prior art, baby's diaper ointment of the present invention has the advantage that
The present invention is safe and non-stimulating, it is possible to gentle effective isolation antibacterial injury, keeps skin bright and clean, simultaneously
There is good antiinflammatory, Shu Min effect；Improving significantly infant diaper rash tool, it has excellence
High/low temperature stability, be suitable to widely popularize application.
Detailed description of the invention:
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not to this
Bright restriction, those skilled in the art are according to the basic thought of the present invention, and various modifications may be made or improves,
But without departing from the basic thought of the present invention, the most within the scope of the present invention.
In the present invention, each composition derives from commercial, and such as Radix Arnebiae extract, to be purchased from Guangzhou tender tea leaves luxuriant growth fine chemistry industry limited
Company, article No. is PW1312CH0228；Ci A dry tree core extract is purchased from chemyunion, and article No. is
CN072-0518。
Described in the embodiment of the present invention 1～3, baby's diaper ointment constituent and consumption thereof are as shown in table 1 below
Baby's diaper ointment formula described in table 1 embodiment 1～3
The preparation method of baby's diaper ointment described in the embodiment of the present invention 1～3:
A) zinc oxide, ethylhexyl palmitate, soybean oil, antioxidant and bisabolol are taken in colloid mill
Upper grinding 4 times, crosses 180 mesh sieves, obtains material I, standby；
B) cetearyl alcohol, surfactant, emulsifying agent, polydimethylsiloxane and stabilizer are added
In oil phase pot, it is heated to 80 DEG C, stirring, until being completely dissolved, obtain material II, standby；
C) water, wetting agent, thickening agent, allantoin and EDETATE SODIUM are added in main cooker, homogenizing 5min,
It is allowed to be uniformly dispersed, is heated to 80 DEG C while stirring, be incubated 10 minutes；
D) by material II suction main cooker, homogenizing 6min, continuously add material I, homogenizing 5min, take out
Vacuum, is cooled to 45 DEG C after insulation 20min, adds Radix Arnebiae extract, thorn A Gan tree core extract, prevents
Rotten agent and essence, stirring is to mix homogeneously；
E) sampling Detection, filters discharging after the assay was approved.
Comparative example 1, a kind of baby's diaper ointment
Thickening agent is sodium acrylate/sodium acryloyldimethyl taurate copolymers, and remaining component and consumption thereof are such as
Embodiment 1.
Preparation method is with reference to preparation method of the present invention.
Comparative example 1 is with the difference of embodiment 1, eliminates xanthan gum, adds sodium acrylate/propylene
The consumption of acyl dimethyltaurine sodium copolymer.
Comparative example 2, a kind of baby's diaper ointment
Remove different n-nonanoic acid Octyl Nitrite, remaining component and consumption thereof such as embodiment 1.
Preparation method is with reference to preparation method of the present invention.
Comparative example 2 is with the difference of embodiment 1, eliminates stabilizer different n-nonanoic acid Octyl Nitrite.
Test example one, stability test
By embodiment 1～3 and comparative example 1～2 diaper ointment successively at-15 DEG C, 5 DEG C, transfer for 40 DEG C and 49 DEG C
Putting 30 days, 60 days and 90 days, investigate its high/low temperature stability, test result is as shown in table 2.
Table 2 test result
As shown in Table 2, embodiment 1～3 diaper ointment high/low temperature excellent in stability, at-15 DEG C, 5 DEG C, 40 DEG C
Place 30 days at 49 DEG C, without layering, precipitation phenomenon after 60 days and 90 days；Comparative example 1 low-temperature stabilization
Property poor, place after 90 days at-15 DEG C and have precipitation phenomenon；Comparative example 2 high-temperature stability is undesirable,
Precipitation phenomenon is had after placing 90 days at 49 DEG C.
Test example two, security test
1. acute skin irritation test
1.1 tested materials: diaper ointment described in the embodiment of the present invention 3.
1.2 animal subjects: regular grade rabbit 4, male and female half and half, body weight 1.86-1.94kg.Tested by Hubei Province
Animal Research Center provides, to Health survey before given the test agent 3 days, Pass Test requirement.
1.3 test method
Test sets diaper ointment group and matched group, and comparison does not deals with, and uses consubstantiality left and right sides self-contrast method,
Totally 4 rabbit, diaper ointment group administered dose: 0.5g/ rabbit.Before test, family's rabbit back spinal column both sides are used by 24h
Battery powered shaver carries out cropping, the left and right each 3cm × 3cm of unhairing scope.Go through before to given the test agent
The skin of unhairing whether damaged because of unhairing, has the skin of damage to test.Tested rabbit is fixed,
Take that 0.5g diaper ointment is applied on the right side of a rabbit back on the most plucked skin, application area is 2.5cm × 2.5cm,
Smear every day once, smear 14 days continuously；Answer cropping before smearing every time.Depilation district, left side does not process work certainly
Body compares.From the beginning of second day, remove residual given the test agent with warm water, smear observed result after 1 hour,
Mark by " cosmetics health specification " (version in 2007) skin wound repair standards of grading.
1.4 results: it is observed that animal shows without systemic toxicity profiles, the local skin that tested material is smeared without erythema and
Edema etc. show, and test result is as shown in table 3.
Table 3 test result
As shown in Table 3, the diaper ointment that the present invention provides is non-stimulated to rabbit repeatedly skin irritation.
Test three, efficacy test
1.1 tested materials: the embodiment of the present invention 1～3 diaper ointment；Shellfish parent's board diaper ointment (shellfish parent mother and baby's articles for use (on
Sea) company limited, article No. IAI49,35g/ prop up)
1.2 test objects: meet baby napkin dermatitis diagnostic criteria, i.e. show as diaper cover pudendum,
Buttocks, medial thigh skin occur that erythema, pimple sometimes can be accompanied dipping, erosion, be oozed out, clear-cut margin,
Age infant between 0-2 year, studies first 1 month and did not used wetting agent in skin lesion district, be not administered orally
Glucocorticoid is crossed in antihistaminic and non-external, and the guardian of experimenter must assure that before assessment
24 hours period, must not skin lesion district use various basic products, must not use hip pad dew, white, newborn
Liquid and glucocorticoid etc..
1.3 method of testings: use multicenter, comparative study random, open, complete case load 80 example, often
Organize 20 examples, be coated with by the embodiment of the present invention 1～3 and matched group diaper ointment, twice daily, respectively at the 3rd day,
Within 7 days, 14 days, carry out efficacy assessment.
1.4 evaluation criterias: 0 point: without skin lesion；1 point: slight, have well-defined scarlet speckle, without vesicle,
Pimple；2 points: moderate, there is well-defined scarlet speckle, with Mild edema, a little vesicle and pimple,
Without rotten to the corn and infection；3 points: severe, there is well-defined scarlet speckle, with Severe edema, large stretch of vesicle
And pimple, and have erosion and pustule, but without skin lesion at skin wrinkle.
1.5 results are as shown in table 4.
Table 4 test result
| Group | Before using | 3 days | 7 days | 14 days |
| Embodiment 1 group | 2.678 | 1.523 | 0.936 | 0.239 |
| Embodiment 2 groups | 2.580 | 1.603 | 1.025 | 0.307 |
| Embodiment 3 groups | 2.314 | 1.721 | 1.104 | 0.423 |
| Matched group | 2.132 | 1.923 | 1.532 | 1.089 |
From upper table 4, the embodiment of the present invention 1～3 diaper ointment is notable to the improvement result of baby napkin dermatitis
Being better than matched group, it has the isolation of excellence, the antibacterial and effect of antiinflammatory alleviation.
Claims (10)
1. baby's diaper ointment, it is characterised in that include the component of following mass percent: Palmic acid
Octyl Nitrite 6～10%, cetearyl alcohol 0.8～2%, soybean oil 0.3～0.8%, polydimethylsiloxane 2～6%,
Stabilizer 0.5-0.9%, wetting agent 8～20%, surfactant 0.5～3%, antioxidant 0.1～0.3%,
Emulsifying agent 2～6.5%, thickening agent 0.5～2%, preservative 0.05～0.5%, zinc oxide 0.8～2%, opopanax
Alcohol 0.05～0.2%, Radix Arnebiae extract 0.3～0.7%, thorn A Gan tree core extract 0.3～0.7%, essence
0.01～0.2%, allantoin 0.1-0.5%, EDETATE SODIUM 0.05-0.2% and water 50～70%.
2. baby's diaper ointment as claimed in claim 1, it is characterised in that include following mass percent
Component: ethylhexyl palmitate 10%, cetearyl alcohol 1%, soybean oil 0.3%, polydimethylsiloxanes
Alkane 6%, stabilizer 0.9%, wetting agent 15%, surfactant 0.5%, antioxidant 0.3%, emulsifying
Agent 5%, thickening agent 0.5%, preservative 0.5%, zinc oxide 0.8%, bisabolol 0.05%, Radix Arnebiae (Radix Lithospermi) carry
Take thing 0.3%, thorn A Gan tree core extract 0.3%, essence 0.1%, allantoin 0.3%, EDETATE SODIUM
0.05% and water 50%.
3. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described wetting agent is selected from
Glycerol and/or propylene glycol.
4. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described antioxidant is
Tocopherol acetas.
5. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described emulsifying agent is selected from
One or more in PEG-100 stearate, glyceryl stearate, stearic acid and triethanolamine.
6. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described preservative is selected from
Methyl hydroxybenzoate and/or phenyl phenol.
7. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described stabilizer is different
N-nonanoic acid Octyl Nitrite.
8. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described thickening agent is selected from
Sodium acrylate/sodium acryloyldimethyl taurate copolymers and/or xanthan gum.
9. baby's diaper ointment as claimed in claim 1 or 2, it is characterised in that described surfactant
By cetearyl glucoside and lauryl alcohol phosphate ester potassium by 1:(0.8～1) weight ratio form.
10. one kind prepare as arbitrary in claim 1～9 as described in the method for baby's diaper ointment, it is characterised in that
Comprise the following steps:
A) zinc oxide, ethylhexyl palmitate, soybean oil, antioxidant and bisabolol are taken in colloid mill
Upper grinding 3-5 time, crosses 180 mesh sieves, obtains material I, standby；
B) cetearyl alcohol, surfactant, emulsifying agent, polydimethylsiloxane and stabilizer are added
In oil phase pot, it is heated to 80～85 DEG C, stirring, until being completely dissolved, obtain material II, standby；
C) water, wetting agent, thickening agent, allantoin and EDETATE SODIUM are added in main cooker, homogenizing 3～5min,
It is allowed to be uniformly dispersed, is heated to 80-85 DEG C while stirring, be incubated 10 minutes；
D) by material II suction main cooker, homogenizing 4～8min, continuously add material I, homogenizing 3～5min,
Evacuation, insulation 15～30min after be cooled to 45 DEG C, add Radix Arnebiae extract, thorn A Gan tree core extract,
Preservative and essence, stirring is to mix homogeneously；
E) sampling Detection, filters discharging after the assay was approved.
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| CN201610537302.1A CN105997718B (en) | 2016-07-08 | 2016-07-08 | A kind of baby's diaper ointment and preparation method thereof |
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727009A (en) * | 2017-01-03 | 2017-05-31 | 广州科玛生物科技股份有限公司 | A kind of baby moistens moisturiser and preparation method thereof again |
| CN107019659A (en) * | 2017-04-27 | 2017-08-08 | 福建春辉生物工程有限公司 | Baby's diaper ointment |
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| CN110638727A (en) * | 2019-11-14 | 2020-01-03 | 广州一一生物技术有限公司 | Infant hip-protecting composition and preparation method and application thereof |
| CN110652477A (en) * | 2019-08-15 | 2020-01-07 | 广州欧盛化妆品有限公司 | Infant repair cream |
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| WO2024059530A1 (en) * | 2022-09-15 | 2024-03-21 | The Procter & Gamble Company | Absorbent article comprising a fragrance and an odor control composition |
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| CN106727009A (en) * | 2017-01-03 | 2017-05-31 | 广州科玛生物科技股份有限公司 | A kind of baby moistens moisturiser and preparation method thereof again |
| CN107019659A (en) * | 2017-04-27 | 2017-08-08 | 福建春辉生物工程有限公司 | Baby's diaper ointment |
| CN107661362A (en) * | 2017-09-12 | 2018-02-06 | 广州暨南生物医药研究开发基地有限公司 | A kind of red hip nursing ointment and preparation method thereof |
| CN108403546A (en) * | 2018-04-15 | 2018-08-17 | 啵噜噜（广州）婴儿用品科技有限公司 | It is a kind of to provide special care to cream suitable for infant |
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| CN109010144A (en) * | 2018-10-17 | 2018-12-18 | 北京爸爸的选择科技有限公司 | A kind of baby's maintenance cream and preparation method thereof |
| CN109276470A (en) * | 2018-11-09 | 2019-01-29 | 贝亲母婴用品（上海）有限公司 | A kind of wind wind reparation ointment for baby |
| CN109431905A (en) * | 2018-12-25 | 2019-03-08 | 广州市络捷生物科技有限公司 | A kind of Radix Arnebiae extract and its preparation method and application |
| CN109431905B (en) * | 2018-12-25 | 2022-03-29 | 广州市络捷生物科技有限公司 | Lithospermum extract and preparation method and application thereof |
| CN109771338A (en) * | 2019-03-12 | 2019-05-21 | 广州健朗医用科技有限公司 | A kind of infant's diaper ointment and its preparation process |
| CN110652477A (en) * | 2019-08-15 | 2020-01-07 | 广州欧盛化妆品有限公司 | Infant repair cream |
| CN110638727A (en) * | 2019-11-14 | 2020-01-03 | 广州一一生物技术有限公司 | Infant hip-protecting composition and preparation method and application thereof |
| CN110638727B (en) * | 2019-11-14 | 2022-06-14 | 广州一一生物技术有限公司 | Infant hip-protecting composition and preparation method and application thereof |
| CN111374924A (en) * | 2020-03-18 | 2020-07-07 | 广东袋鼠妈妈生物科技有限公司 | Baby wheat fresh extract raw pulp hip-protecting cream and preparation method thereof |
| CN111437234A (en) * | 2020-05-13 | 2020-07-24 | 杭州米友圈科技有限公司 | Baby hip protection cream |
| CN111870564A (en) * | 2020-08-13 | 2020-11-03 | 广州贝玛生物科技有限公司 | Compound lithospermum ointment for infants and preparation method thereof |
| CN113925827A (en) * | 2021-10-13 | 2022-01-14 | 振德医疗用品股份有限公司 | Incontinence nursing ointment and preparation method thereof |
| WO2024059530A1 (en) * | 2022-09-15 | 2024-03-21 | The Procter & Gamble Company | Absorbent article comprising a fragrance and an odor control composition |
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