CN113925827A - Incontinence nursing ointment and preparation method thereof - Google Patents
Incontinence nursing ointment and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
The invention discloses an incontinence nursing ointment and a preparation method thereof. The incontinence nursing ointment has good waterproof isolation performance, can form a protective layer at the smearing position to isolate external irritants, plays a role of physical barrier, can resist repeated scouring, and has excellent anti-dipping capacity; contains emollient, can fill the gap of the cuticle fragment, can form a layer of oil film barrier at the smearing position, can reduce the friction between the skin and the urine-proof pad, the diaper and the clothes, and reduce the skin damage of the incontinence patient; the incontinence nursing ointment has the advantages of air permeability, water resistance, isolation, excellent anti-impregnation performance and convenient use, and is used for clinically relieving skin irritation of incontinence patients caused by moisture, urine and/or excrement.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and relates to a nursing ointment, in particular to an incontinence nursing ointment which has the advantages of air permeability, waterproof isolation, excellent anti-dipping property, convenient use and capability of clinically relieving skin irritation of an incontinence patient caused by moisture, urine and/or excrement and a preparation method thereof.
Background
The total number of patients affected by incontinence worldwide has currently exceeded 2 million people, with 65 years old being the major incontinent population. In recent years, the degree of aging of the population has been increasing, and the aged 65 years and older is increasing. The enormous and rapidly growing population of the elderly provides a large potential consumer segment for the development of the adult incontinence product market. Meanwhile, with the gradual improvement of the consumption concept of domestic incontinence people, the functional requirements of adult incontinence products caused by operations, fertility or long-distance transportation are increasing.
In the aspect of western medicines, no external medicine which is used for treating and protecting early and middle-stage incontinent dermatitis and has simple and convenient use and obvious effect is available at present. Incontinent dermatitis can occur in clinic, community and family care, and is especially common for elderly patients and long-term bedridden patients without mobility. The skin of healthy people has pH value of 4-6 and is acidic. The pH plays an important acidic outer membrane role in the skin barrier. This acidic outer membrane helps regulate resident bacteria (skin microorganisms) on the skin and also ensures optimal stratum corneum binding barrier function. Incontinence Associated Dermatitis (IAD) is prone to occur when the local stratum corneum barrier function is impaired when the skin pH increases due to frequent bowel and urine irritation. Secondary infection can be caused when the patient is serious, so that the pain of the patient is brought, the hospitalization time is prolonged, the waste of medical resources is caused, and the unnecessary nursing workload is increased.
The current way of care for incontinence sufferers is generally to use a diaper pad or a disposable urine isolation pad to be laid under the buttocks of the sufferer after the affected part of the incontinence is cleaned and dried, or wear an incontinence diaper on the sufferer.
The main defects are as follows: (1) when a patient is found to be incontinent by medical staff or family members, the skin of the patient is often soaked by the excrement of the patient for a period of time, and although the urine isolation pad and the urine pad have certain absorbability, the contacted skin is also in a moist environment after the excrement is absorbed, and the moisture cannot be effectively isolated. (2) Prolonged contact rubbing of the incontinence patient's skin against underwear, urine pads or diapers can cause damage to the skin.
Disclosure of Invention
In order to solve the problems, the invention provides an incontinence care ointment which has the advantages of air permeability, waterproof isolation, excellent anti-impregnation property and convenient use and is used for clinically relieving skin irritation of incontinence patients caused by moisture, urine and/or excrement.
The invention also provides a preparation method of the incontinence nursing ointment.
In order to achieve the purpose, the invention adopts the following technical scheme:
an incontinence nursing ointment comprises the following components in parts by weight: 4-8 parts of glycerol, 3-7 parts of butanediol, 2-5 parts of caprylic/capric triglyceride, 1-4 parts of hydrogenated polyisobutene, 1-4 parts of ethylhexyl palmitate, 8-12 parts of a humectant, 10-15 parts of a softening agent, 2-3 parts of a film forming agent, 1-3 parts of an emulsifier, 0.5-1.0 part of a preservative and 33-68 parts of water.
In the technical scheme, the hydrogenated polyisobutene is added to the formula and has the functions of film forming, a softening agent and a viscosity control agent, and the formula has 3 functional functions simultaneously; the ethylhexyl palmitate is used as a softening agent and a solvent and has the function of a solvent; the components with the waterproof and isolating functions are film forming substances in the formula and substances with the functions of film forming and skin moistening in the oil phase; the anti-dipping component is a substance which has the functions of film forming and skin moistening in a film forming substance and an oil phase in the formula.
The incontinence nursing ointment has good waterproof isolation performance, can form a protective layer at the smearing position to isolate external irritants, plays a role of a physical barrier, can resist repeated scouring, and has excellent anti-dipping capacity.
Most preferably, the incontinence care ointment consists of the following components in parts by weight: 6 parts of glycerol, 5 parts of butanediol, 4 parts of caprylic/capric triglyceride, 3 parts of hydrogenated polyisobutene, 2 parts of ethylhexyl palmitate, 9 parts of a humectant, 11 parts of a softening agent, 2.5 parts of a film forming agent, 2 parts of an emulsifier, 0.5 part of a preservative and 55 parts of water.
In a preferred embodiment of the present invention, the humectant is one or more of propylene glycol, hexylene glycol, β -glucan, polyethylene glycol 200 or sodium hyaluronate.
Most preferably, the humectant is a combination of ethylene glycol, beta-glucan and sodium hyaluronate.
As a preferred embodiment of the present invention, the emollient is one or more of isopropyl myristate, cetyl palmitate, butyl stearate, caprylic capric triglyceride or cyclopentadimethylsiloxane.
Most preferably, the emollient is a combination of cetyl palmitate, caprylic capric triglyceride and cyclopentadimethylsiloxane.
In a preferred embodiment of the present invention, the film-forming agent is one or more of trimethylsiloxysilicate, polyvinylpyrrolidone/hexadecene copolymer, acrylic resin, or dimethylsiloxane copolymer.
Most preferably, the film former is a combination of trimethylsiloxysilyl silicate (TMS803), an acrylic resin and a dimethylsiloxane copolymer (KP 545).
As a preferred embodiment of the present invention, the emulsifier is one or more of cetyl PEGPPG-10/1 polydimethylsiloxane, PEG-30 dipolyhydroxystearate, sorbitan sesquioleate, polyglycerol-3 polyricinoleate or polyglycerol-3 ricinoleate.
Most preferably, the emulsifier is a combination of cetyl PEGPPG-10/1 dimethicone and PEG-30 dipolyhydroxystearate.
As a preferred embodiment of the invention, the preservative is one or more of p-hydroxyacetophenone, 1, 2-glutaraldehyde or 1, 2-octanediol.
Most preferably, the preservative is p-hydroxyacetophenone
The preparation method of the incontinence nursing ointment comprises the following steps:
1) weighing glycerol, butanediol, humectant and water according to the formula ratio, adding into a water phase pot, stirring and heating, and keeping the temperature for later use;
2) weighing caprylic capric triglyceride, hydrogenated polyisobutene, ethylhexyl palmitate, a softening agent, a film forming agent, an emulsifier and a preservative according to the formula ratio, adding into an oil phase pot, stirring and heating, and keeping the temperature for later use;
3) adding the materials in the oil phase pot in the step 2) into an emulsifying pot, maintaining the temperature of the materials, adding the materials in the water phase pot in the step 1), homogenizing and stirring, and homogenizing and emulsifying;
4) and 3) cooling and filling after emulsification is finished.
In a preferred embodiment of the present invention, in step 1) and step 2), the conditions of stirring and heating are as follows: the stirring speed is 10-50r/min, and the temperature is 70-85 ℃.
As a preferable scheme of the invention, in the step 3), the rotation speed of the homogenizing and stirring is 100-2800r/min, and the emulsifying time is 8-10 min.
In a preferred embodiment of the present invention, in step 4), the temperature is cooled to 30 to 40 ℃.
Compared with the prior art, the invention has the following beneficial effects:
1) the incontinence nursing ointment has good waterproof isolation performance, can form a protective layer at the smearing position to isolate external irritants, plays a role of physical barrier, can resist repeated scouring, and has excellent anti-dipping capacity;
2) the incontinence nursing ointment contains the emollient, can fill the gaps of the cuticle fragments, can form a layer of oil film barrier at the smearing position, can reduce the friction between the skin and the urine isolation pad, the diaper and clothes, and can reduce the skin damage of an incontinence patient;
3) the incontinence nursing ointment contains moisturizing substances, and can increase skin moisture;
4) the protective layer formed at the position where the incontinence nursing ointment paste is applied has good air permeability;
5) the incontinence nursing ointment has the advantages of air permeability, water resistance, isolation, excellent anti-impregnation performance and convenient use, and is used for clinically relieving skin irritation of incontinence patients caused by moisture, urine and/or excrement.
Drawings
FIG. 1 is a top view of the water-resistant barrier effect of the incontinence care ointment of the invention.
FIG. 2 is a top view of the anti-maceration properties of the incontinence care ointment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
This example provides an incontinence care ointment having the specific formulation shown in Table 1.
The preparation method of the incontinence nursing ointment comprises the following steps:
1) weighing the water phase materials according to the weight parts, adding the water phase materials into a water phase pot, stirring at 45r/min, heating to 75 ℃, and preserving heat for later use;
2) weighing the oil phase materials according to the weight parts, adding the oil phase materials into an oil phase pot, stirring at 45r/min, heating to 75 ℃, and preserving heat for later use;
3) pumping the materials in the oil phase pot into an emulsifying pot, maintaining the temperature of the materials at 75 ℃, pumping the materials in the water phase pot into the emulsifying pot, starting homogenizing and stirring at the rotation speed of 1500r/min, and homogenizing and emulsifying for 8 min;
4) and (3) closing homogenizing and stirring after homogenizing and emulsifying, slowly cooling to 38 ℃, and filling to obtain the incontinence nursing ointment.
TABLE 1 formulation
Example 2
This example provides an incontinence care ointment having the specific formulation shown in Table 2.
The preparation method of the incontinence nursing ointment comprises the following steps:
1) weighing the water phase materials according to the weight parts, adding the water phase materials into a water phase pot, stirring and heating to 78 ℃ at 15r/min, and preserving heat for later use;
2) weighing the oil phase materials according to the weight parts, adding the oil phase materials into an oil phase pot, stirring and heating to 78 ℃ at 35r/min, and preserving heat for later use;
3) pumping the materials in the oil phase pot into an emulsifying pot, maintaining the temperature of the materials at 78 ℃, pumping the materials in the water phase pot into the emulsifying pot, starting homogenizing and stirring at the rotation speed of 1000r/min, and homogenizing and emulsifying for 8 min;
4) and (3) closing homogenizing and stirring after homogenizing and emulsifying, slowly cooling to 35 ℃, and filling to obtain the incontinence nursing ointment.
TABLE 2 formulation
Example 3
This example provides an incontinence care ointment having the specific formulation shown in Table 3.
The preparation method of the incontinence nursing ointment comprises the following steps:
1) weighing the water phase materials according to the weight parts, adding the water phase materials into a water phase pot, stirring and heating to 80 ℃ at 25r/min, and preserving heat for later use;
2) weighing the oil phase materials according to the weight parts, adding the oil phase materials into an oil phase pot, stirring and heating to 80 ℃ at 40r/min, and preserving heat for later use;
3) pumping the materials in the oil phase pot into an emulsifying pot, maintaining the temperature of the materials at 80 ℃, pumping the materials in the water phase pot into the emulsifying pot, starting homogenizing and stirring at the rotation speed of 750r/min, and homogenizing and emulsifying for 10 min;
4) and (3) closing homogenizing and stirring after homogenizing and emulsifying, slowly cooling to 35 ℃, and filling to obtain the incontinence nursing ointment.
TABLE 3 formulation
Efficacy evaluation of incontinence Care ointment
Test of waterproof isolation Performance
And (3) isolation test: 12 pieces of filter paper were taken and divided into 4 groups of 3 replicates each. Marking a circle with the diameter of 5cm at the center of the filter paper, correspondingly coating 0.1g of the paste in the circle, not coating the circle as a blank control group, padding water-absorbing non-woven fabrics on each pad below a filter paper piece, standing for 5min after coating to ensure that the filter paper in the circle is soaked by the paste, respectively dripping 0.5ml of test solution (1L of physiological saline and 2ml of Coomassie brilliant blue) in the circle, observing and recording the permeation time of the dyeing solution, taking the non-flowable dyeing solution on the filter paper piece as a time node, recording the required permeation time, and calculating the average value of each group, wherein the results are shown in a figure 1 and a table 4.
In fig. 1, blank groups, example 1, example 2, and example 3 are shown from left to right.
TABLE 4 waterproof isolation Performance test results
Moisture permeability test
8 pieces of filter paper were taken and divided into 4 groups of 2 replicates each. Fixing filter paper on moisture permeability detection device (inner diameter 6cm), coating 0.11 above paste on corresponding filter paper sheet, not coating as blank control group, placing the device in oven at 37 deg.C for 6h, calculating the difference before and after device test to obtain moisture permeability, and the result is shown in Table 5.
TABLE 5 moisture vapor transmission Performance test results
Resistance to impregnation test
4 1000ml beakers were prepared, 1L of physiological saline in each beaker, and then 1ml of Coomassie Brilliant blue stain was added to each beaker. Taking 4 filter paper sheets, marking, correspondingly coating 1g of the paste on the front and back sides of the filter paper sheets, not coating the filter paper sheets as a blank control group, standing for 5min after coating to ensure that the whole filter paper is soaked by the paste, respectively putting the filter paper sheets into a beaker for soaking for 6h, taking out the filter paper sheets, flatly paving the taken-out filter paper sheets, slightly wiping off the paste on the surfaces of the filter paper sheets by using a water-absorbing non-woven fabric, and comparing the color depth among the filter paper sheets, wherein the result is shown in figure 2, and in figure 2, the blank group, the embodiment 1, the embodiment 2 and the embodiment 3 are sequentially arranged from left to right.
Referring to fig. 2, the test results are: the blank was fully impregnated, example 2 was partially impregnated, and examples 1 and 3 were slightly impregnated.
Scouring resistance test
Taking 4 testers, marking 4 square frames of 2.5cm x 5cm on the arm of each tester, marking, coating 0.05g of the paste in 4 frames, taking an uncoated group as a blank control, standing for 5min after coating, spraying the test area for 3 times by using a sprayer filled with water, and observing whether round water beads are formed in each test area. After observation, the water on the skin is slightly absorbed by the water-absorbing non-woven fabric sheet, the water-absorbing non-woven fabric sheet soaked by the normal saline is used for continuously cleaning the test area on the arm in a light pressing mode for 7 times, after the cleaning, the test area is sprayed for 3 times, and whether the test area has round water drops or not is observed. The above steps were repeated for a number of cycles until no beads appeared after spraying, and the final number of cycles for each test zone was recorded, the results are shown in table 6.
TABLE 6 results of the impact resistance test
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that the foregoing and other changes, omissions and deviations in the form and detail thereof may be made without departing from the scope of this invention. Those skilled in the art can make various changes, modifications and equivalent arrangements, which are equivalent to the embodiments of the present invention, without departing from the spirit and scope of the present invention, and which may be made by utilizing the techniques disclosed above; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (10)
1. An incontinence nursing ointment is characterized by comprising the following components in parts by weight: 4-8 parts of glycerol, 3-7 parts of butanediol, 2-5 parts of caprylic/capric triglyceride, 1-4 parts of hydrogenated polyisobutene, 1-4 parts of ethylhexyl palmitate, 8-12 parts of a humectant, 10-15 parts of a softening agent, 2-3 parts of a film forming agent, 1-3 parts of an emulsifier, 0.5-1.0 part of a preservative and 33-68 parts of water.
2. The incontinence care ointment of claim 1 wherein the humectant is one or more of propylene glycol, hexylene glycol, β -glucan, polyethylene glycol 200 or sodium hyaluronate.
3. An incontinence care ointment as claimed in claim 1, wherein the emollient is one or more of isopropyl myristate, cetyl palmitate, butyl stearate, caprylic capric triglyceride or cyclopenta dimethyl silicone.
4. An incontinence care ointment as claimed in claim 1, wherein the film former is one or more of trimethylsiloxysilicate, polyvinylpyrrolidone/hexadecene copolymer, acrylic resin or dimethylsiloxane copolymer.
5. An incontinence care ointment as claimed in claim 1, wherein the emulsifier is one or more of cetyl peggppg-10/1 dimethicone, PEG-30 dipolyhydroxystearate, sorbitan sesquioleate, polyglycerol-3 polyricinoleate or polyglycerol-3 ricinoleate.
6. An incontinence care ointment as claimed in claim 1, characterised in that the preservative is one or more of p-hydroxyacetophenone, 1, 2-glutaraldehyde or 1, 2-octanediol.
7. A process for the preparation of an incontinence care ointment as claimed in any of claims 1 to 6, characterized in that the preparation process comprises the following steps:
1) weighing glycerol, butanediol, humectant and water according to the formula ratio, adding into a water phase pot, stirring and heating, and keeping the temperature for later use;
2) weighing caprylic capric triglyceride, hydrogenated polyisobutene, ethylhexyl palmitate, a softening agent, a film forming agent, an emulsifier and a preservative according to the formula ratio, adding into an oil phase pot, stirring and heating, and keeping the temperature for later use;
3) adding the materials in the oil phase pot in the step 2) into an emulsifying pot, maintaining the temperature of the materials, adding the materials in the water phase pot in the step 1), homogenizing and stirring, and homogenizing and emulsifying;
4) and 3) cooling and filling after emulsification is finished.
8. The method for preparing an incontinence-care ointment as claimed in claim 7, wherein the conditions of stirring and heating in step 1) and step 2) are as follows: the stirring speed is 10-50r/min, and the temperature is 70-85 ℃.
9. The method as claimed in claim 7, wherein the rotation speed of the homogenizing and stirring in step 3) is 100-.
10. The process for preparing an incontinence care ointment as claimed in claim 7, wherein, in step 4), cooling is carried out to a temperature of 30 to 40 ℃.
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2021
- 2021-10-13 CN CN202111192422.XA patent/CN113925827A/en active Pending
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| CN112245347A (en) * | 2020-10-09 | 2021-01-22 | 名臣健康用品股份有限公司 | Hip-protecting composition for preventing and treating diaper rash and preparation method thereof |
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