CN105997718B - A kind of baby's diaper ointment and preparation method thereof - Google Patents
A kind of baby's diaper ointment and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention belongs to skincare product fields, more particularly to a kind of baby's diaper ointment and preparation method thereof, the component including following mass percent: ethylhexyl palmitate, cetostearyl alcohol, soybean oil, dimethyl silicone polymer, stabilizer, moisturizer, surfactant, antioxidant, emulsifier, thickener, preservative, zinc oxide, bisabolol, Radix Arnebiae extract, thorn A Gan tree benevolence extract, essence, allantoin, EDETATE SODIUM and water.Its is safe and non-stimulating, can be effectively isolated bacterium infection, keeps skin delicate bright and clean, while having excellent height temperature stability.
Description
Technical field
The invention belongs to skin care fields, and in particular to a kind of baby's diaper ointment and preparation method thereof.
Background technique
The red hip of baby are medically also known as " diaper rash " or " diaper rash ".The factor that diaper rash occurs also has very
More: baby's keratoderma is thin, and endothelium is aqueous and chloride is more, is easy allergy；Often excessive milk, urine, paper diaper friction etc.
Stimulation, destroys the natural sebum protective film of skin；Skin of buttock is moist for a long time, wears airtight and long-time service paper urine
Trousers easily cause germ in skin surface mass propagation；It is original to break baby's skin often in contact with some cleaning solutions for buttocks skin
Profitable strain balance, Flora Disturbance cause the protective effect of skin and mucosa to be destroyed.
Existing baby's diaper ointment is generally made of chemicals grease, talcum powder, essence, preservative, emulsifier, effect
Be skin surface formed protective film, the appearance for " red hip " phenomenon of releiving, but its to have already appeared " diaper rash " symptom by
The effect that damage skin is not releived and repaired.
Chinese patent application 201210473764.3 discloses a kind of infant hip protection gel, by the original of following mass percent
Material is made: propylene glycol 4-6%, Asian puccoon root extract 3-5%, Acacia berry extract 3-5%, EDETATE SODIUM 0.04-0.06%,
Carbomer sodium 0.4-0.6%, Melaleuca alternifolia leaf oil 0.01-0.03%, Bis(hydroxymethyl)imidazolidinyl urea 0.3-0.5%,
Remaining is deionized water.The invention infant hip protection gel has the function of moist moisturizing, sensitive skin of releiving, and can effectively prevent baby
Youngster's skin of buttock is coarse, cracks, and is especially suitable for having already appeared the damaged skin of " diaper rash " symptom, baby uses safe, stingless
Swash.But the stability of the infant hip protection gel is undesirable.
Summary of the invention
It is of the invention to provide a kind of baby's diaper ointment and its preparation in order to solve the technical problems existing in the prior art
Method, it is safe and non-stimulating, it can be effectively isolated bacterium infection, keep skin delicate bright and clean, while having excellent high/low temperature steady
It is qualitative.
The present invention provides a kind of baby's diaper ointment, the component including following mass percent: ethylhexyl palmitate 6~
10%, cetostearyl alcohol 0.8~2%, soybean oil 0.3~0.8%, dimethyl silicone polymer 2~6%, stabilizer 0.5-
0.9%, moisturizer 8~20%, surfactant 0.5~3%, antioxidant 0.1~0.3%, emulsifier 2~6.5%, thickening
Agent 0.5~2%, preservative 0.05~0.5%, zinc oxide 0.8~2%, bisabolol 0.05~0.2%, Radix Arnebiae extract 0.3
~0.7%, A Gan tree benevolence extract 0.3~0.7%, essence 0.01~0.2%, allantoin 0.1-0.5%, EDETATE SODIUM are pierced
0.05-0.2% and water 50~70%.
Preferably, baby's diaper ointment includes the component of following mass percent: ethylhexyl palmitate 10%, spermaceti
Stearyl alcohol 1%, soybean oil 0.3%, dimethyl silicone polymer 6%, stabilizer 0.9%, moisturizer 15%, surfactant
0.5%, antioxidant 0.3%, emulsifier 5%, thickener 0.5%, preservative 0.5%, zinc oxide 0.8%, bisabolol
0.05%, Radix Arnebiae extract 0.3%, thorn A Gan tree benevolence extract 0.3%, essence 0.1%, allantoin 0.3%, EDETATE SODIUM
0.05% and water 50%.
Preferably, baby's diaper ointment includes the component of following mass percent: ethylhexyl palmitate 6%, spermaceti
Stearyl alcohol 0.8%, soybean oil 0.5%, dimethyl silicone polymer 2%, stabilizer 0.5%, moisturizer 8%, surfactant
1%, antioxidant 0.2%, emulsifier 2%, thickener 1%, preservative 0.2%, zinc oxide 1%, bisabolol 0.1%, purple
Careless extract 0.5%, thorn A Gan tree benevolence extract 0.4%, essence 0.01%, allantoin 0.1%, EDETATE SODIUM 0.1% and
Water 60%.
Preferably, baby's diaper ointment includes the component of following mass percent: ethylhexyl palmitate 8%, spermaceti
Stearyl alcohol 2%, soybean oil 0.8%, dimethyl silicone polymer 4%, stabilizer 0.7%, moisturizer 20%, surfactant 3%,
Antioxidant 0.1%, emulsifier 6.5%, thickener 2%, preservative 0.05%, zinc oxide 2%, bisabolol 0.2%, Asian puccoon
Extract 0.7%, thorn A Gan tree benevolence extract 0.7%, essence 0.2%, allantoin 0.5%, EDETATE SODIUM 0.2% and water
50%.
Preferably, the moisturizer is selected from glycerol and/or propylene glycol.
Preferably, the moisturizer is by glycerol and propylene glycol by 1:(0.3~1) weight ratio form.
Preferably, the antioxidant is tocopherol acetate.
Preferably, the emulsifier is in PEG-100 stearate, stearine, stearic acid and triethanolamine
One or more of combinations.
Preferably, the emulsifier presses 1 by PEG-100 stearate, stearine, stearic acid and triethanolamine:
(0.5~1): (1~4): the weight ratio composition of (0.05~2).
Preferably, the preservative is selected from methyl hydroxybenzoate and/or phenoxetol.
Preferably, the preservative presses (0.05~0.2) by methyl hydroxybenzoate and phenoxetol: the weight of (0.05~0.2)
Amount is than composition.
Preferably, the stabilizer is isononanoic acid ethylhexyl.
Preferably, the thickener is selected from sodium acrylate/sodium acryloyldimethyl taurate copolymers and/or xanthan gum.
Preferably, the thickener presses (0.5 by sodium acrylate/sodium acryloyldimethyl taurate copolymers and xanthan gum
~0.9): the weight ratio composition of (0.3~0.5).
Preferably, the surfactant presses 1:(0.8~1 by cetearyl glucoside and laurel alcohol ether phosphate potassium)
Weight ratio composition.
Correspondingly, the present invention also provides a kind of methods for preparing above-mentioned baby's diaper ointment, comprising the following steps:
A) take zinc oxide, ethylhexyl palmitate, soybean oil, antioxidant and bisabolol in grinding 3-5 on colloid mill
It is secondary, 180 meshes are crossed, material I is obtained, it is spare；
B) cetostearyl alcohol, surfactant, emulsifier, dimethyl silicone polymer and stabilizer are added in oily phase pot,
80~85 DEG C are heated to, stirring obtains material II until being completely dissolved, spare；
C) water, moisturizer, thickener, allantoin and EDETATE SODIUM are added in main cooker, 3~5min of homogeneous is allowed to disperse
Uniformly, it is heated to 80-85 DEG C while stirring, keeps the temperature 10 minutes；
D) material II is pumped into main cooker, 4~8min of homogeneous continuously adds material I, and 3~5min of homogeneous is vacuumized, and protects
It is cooled to 45 DEG C after 15~30min of temperature, Radix Arnebiae extract, thorn A Gan tree benevolence extract, preservative and essence is added, stirring is extremely
It is uniformly mixed；
E) sampling Detection, after the assay was approved filtering and discharging.
In the present invention zinc oxide can effectively waterproof, isolation, restrain skin, and extend effective antibacterial time；Asian puccoon is extracted
Object and bisabolol have hemostasis, anti-inflammatory, convergence, moist promotion skin regeneration and other effects；The dry tree benevolence extract of Ci A is to skin
Have effects that moisturizing, nourishing and calmness, and zinc oxide bring skin can be stimulated and be effectively relieved；Palm acid ethyl
Own ester improves the permeability of effective component；Stabilizer and surfactant is added, solves the skill that paste is easily precipitated in low temperature
Art problem improves the stability of diaper ointment；Protective film is formed in skin surface using soybean oil and dimethyl silicone polymer, is subtracted
Few stimulation of the zinc oxide to infant skin；Xanthan gum and sodium acrylate/sodium acryloyldimethyl taurate copolymers is selected to answer
With use, so that diaper ointment is easy to apply the viscosity for opening up and being able to maintain diaper ointment, be not easy to trickle after smearing.The present invention can be mild
Effective isolation bacterium injury, keeps skin bright and clean, while having good anti-inflammatory, Shu Min effect, can mildly moisten moisturizing,
Alleviate stimulation, improve skin resistance, safely and effectively treat infant diaper rash, while having that stability is high, high excellent of permeability
Point.
Compared with prior art, baby's diaper ointment of the invention has the advantage that
The present invention is safe and non-stimulating, and bacterium injury mildly can effectively be isolated, keep skin bright and clean, while having good
Anti-inflammatory, Shu Min effect；It improves significantly to infant diaper rash tool, with excellent height temperature stability, is suitable for
Widely popularize application.
Specific embodiment:
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
In the present invention respectively composition derive from it is commercially available, if Radix Arnebiae extract is purchased from Guangzhou Ming Hui Fine Chemical Co., Ltd,
Article No. is PW1312CH0228；The dry tree benevolence extract of Ci A is purchased from chemyunion, article No. CN072-0518.
The baby's diaper ointment constituent of the embodiment of the present invention 1~3 and its dosage are as shown in table 1 below
Baby's hip pad paste formulation described in 1 Examples 1 to 3 of table
The preparation method of the baby's diaper ointment of the embodiment of the present invention 1~3:
A) take zinc oxide, ethylhexyl palmitate, soybean oil, antioxidant and bisabolol in grinding 4 times on colloid mill,
180 meshes are crossed, material I is obtained, it is spare；
B) cetostearyl alcohol, surfactant, emulsifier, dimethyl silicone polymer and stabilizer are added in oily phase pot,
80 DEG C are heated to, stirring obtains material II until being completely dissolved, spare；
C) water, moisturizer, thickener, allantoin and EDETATE SODIUM are added in main cooker, homogeneous 5min, it is equal is allowed to dispersion
It is even, it is heated to 80 DEG C while stirring, keeps the temperature 10 minutes；
D) material II is pumped into main cooker, homogeneous 6min continuously adds material I, and homogeneous 5min is vacuumized, and keeps the temperature 20min
After be cooled to 45 DEG C, be added Radix Arnebiae extract, thorn A Gan tree benevolence extract, preservative and essence, stirring is to uniformly mixed；
E) sampling Detection, after the assay was approved filtering and discharging.
Comparative example 1, a kind of baby's diaper ointment
Thickener is sodium acrylate/sodium acryloyldimethyl taurate copolymers, remaining component and its dosage such as embodiment
1。
Preparation method refers to preparation method of the present invention.
Comparative example 1 the difference from embodiment 1 is that, eliminate xanthan gum, increase sodium acrylate/acryloyldimethyl ox
The dosage of sodium sulfonate copolymers.
Comparative example 2, a kind of baby's diaper ointment
Remove isononanoic acid ethylhexyl, remaining component and its dosage such as embodiment 1.
Preparation method refers to preparation method of the present invention.
Comparative example 2 the difference from embodiment 1 is that, eliminate stabilizer isononanoic acid ethylhexyl.
Test example one, stability test
Examples 1 to 3 and 1~2 diaper ointment of comparative example are successively placed 30 days at -15 DEG C, 5 DEG C, 40 DEG C and 49 DEG C,
60 days and 90 days, its height temperature stability is investigated, test result is as shown in table 2.
2 test result of table
As shown in Table 2, Examples 1 to 3 diaper ointment high/low temperature excellent in stability is transferred at -15 DEG C, 5 DEG C, 40 DEG C and 49 DEG C
Without layering, precipitation phenomenon after setting 30 days, 60 days and 90 days；1 low-temperature stability of comparative example is poor, after placing 90 days at -15 DEG C
There is precipitation phenomenon；2 high-temperature stability of comparative example is undesirable, has precipitation phenomenon after placing 90 days at 49 DEG C.
Test example two, security test
1. acute skin irritation test
1.1 tested materials: diaper ointment described in the embodiment of the present invention 3.
1.2 animal subjects: regular grade rabbit 4, half male and half female, weight 1.86-1.94kg.It is ground by Hubei Province's experimental animal
Study carefully center offer, to Health survey 3 days before given the test agent, Pass Test was required.
1.3 test method
Test sets diaper ointment group and control group, and control is not dealt with, using androgynous left and right sides self-contrast method, totally 4 families
Rabbit, diaper ointment group administered dose: 0.5g/ rabbit.Cropping is carried out with battery powered shaver to family's rabbit back backbone two sides for 24 hours before test, is gone
The left and right each 3cm × 3cm of hair range.It is going through whether skin of unhairing is damaged because of unhairing before to given the test agent, is haveing damage
Skin should not be tested.Tested rabbit is fixed, 0.5g diaper ointment is taken to be applied on the right side of a rabbit back plucked skin
Upper, application area is 2.5cm × 2.5cm, is smeared daily once, continuous to smear 14 days；Cropping is answered before smearing every time.Left side depilation
Area, which is not handled, makees own control.Since second day, residual given the test agent is removed with warm water, observation is as a result, press after smearing 1 hour
The scoring of " cosmetics health specification " (version in 2007) skin wound repair standards of grading.
1.4 results: it is observed that animal shows without systemic toxicity profiles, the local skin that tested material is smeared is without erythema and oedema etc.
Performance, test result are as shown in table 3.
3 test result of table
As shown in Table 3, diaper ointment provided by the invention is non-stimulated to the multiple skin irritation of rabbit.
Test three, efficacy test
1.1 tested materials: 1~3 diaper ointment of the embodiment of the present invention；(shellfish parent mother and baby articles (Shanghai) are limited for shellfish parent's board diaper ointment
Company, article No. IAI49,35g/ branch)
1.2 test objects: meeting baby napkin dermatitis diagnostic criteria, that is, shows as vulva, the buttocks, thigh of diaper covering
Erythema, papule occurs in inside skin sometimes can be with dipping, erosion, exudation, clear-cut margin, and infant of the age between 0-2 years old is ground
Study carefully and moisturizer was not used in skin lesion area within first 1 month, did not took orally antihistamine and not outer used glucocorticoid, and by
The guardian of examination person must assure that during 24 hours before assessment, must not use various basic products in skin lesion area, must not
Use hip pad dew, frost, lotion and glucocorticoid etc..
1.3 test methods: using multicenter, random, open comparative study, completing case load 80, and every group 20, Tu Yong
The embodiment of the present invention 1~3 and control group diaper ointment, twice daily, respectively at the 3rd day, 7 days, 14 days progress efficacy assessments.
1.4 evaluation criterias: 0 point: without skin lesion；1 point: it is slight, there are the scarlet spot of clear-cut margin, no blister, papule；2 points: in
Degree, there is the scarlet spot of clear-cut margin, with Mild edema, a little blister and papule, no rotten to the corn and infection；3 points: severe has side
The clear scarlet spot of edge with Severe edema, large stretch of blister and papule, and has rotten to the corn and warts, but without skin lesion at skin wrinkle.
1.5 the results are shown in Table 4.
4 test result of table
| Group | Before use | 3 days | 7 days | 14 days |
| Example 1 group | 2.678 | 1.523 | 0.936 | 0.239 |
| 2 groups of embodiment | 2.580 | 1.603 | 1.025 | 0.307 |
| 3 groups of embodiment | 2.314 | 1.721 | 1.104 | 0.423 |
| Control group | 2.132 | 1.923 | 1.532 | 1.089 |
By upper table 4 it is found that 1~3 diaper ointment of the embodiment of the present invention is significantly better than pair the improvement result of baby napkin dermatitis
According to group, have the function of that excellent isolation, antibacterial and anti-inflammatory are alleviated.
Claims (9)
1. a kind of baby's diaper ointment, which is characterized in that the component including following mass percent: ethylhexyl palmitate 6~
10%, cetostearyl alcohol 0.8~2%, soybean oil 0.3~0.8%, dimethyl silicone polymer 2~6%, stabilizer 0.5-
0.9%, moisturizer 8~20%, surfactant 0.5~3%, antioxidant 0.1~0.3%, emulsifier 2~6.5%, thickening
Agent 0.5~2%, preservative 0.05~0.5%, zinc oxide 0.8~2%, bisabolol 0.05~0.2%, Radix Arnebiae extract 0.3
~0.7%, A Gan tree benevolence extract 0.3~0.7%, essence 0.01~0.2%, allantoin 0.1-0.5%, EDETATE SODIUM are pierced
0.05-0.2% and water 50~70%；The stabilizer is isononanoic acid ethylhexyl.
2. baby's diaper ointment as described in claim 1, which is characterized in that the component including following mass percent: palmitinic acid
Ethylhexyl 10%, cetostearyl alcohol 1%, soybean oil 0.3%, dimethyl silicone polymer 6%, stabilizer 0.9%, moisturizer
15%, surfactant 0.5%, antioxidant 0.3%, emulsifier 5%, thickener 0.5%, preservative 0.5%, zinc oxide
0.8%, bisabolol 0.05%, Radix Arnebiae extract 0.3%, thorn A Gan tree benevolence extract 0.3%, essence 0.1%, allantoin
0.3%, EDETATE SODIUM 0.05% and water 50%.
3. baby's diaper ointment as claimed in claim 1 or 2, which is characterized in that the moisturizer is selected from glycerol and/or the third two
Alcohol.
4. baby's diaper ointment as claimed in claim 1 or 2, which is characterized in that the antioxidant is tocopherol acetate.
5. baby's diaper ointment as claimed in claim 1 or 2, which is characterized in that the emulsifier is selected from PEG-100 stearic acid
One or more of ester, stearine, stearic acid and triethanolamine.
6. baby's diaper ointment as claimed in claim 1 or 2, which is characterized in that the preservative is selected from methyl hydroxybenzoate and/or benzene
Ethoxy-ethanol.
7. baby's diaper ointment as claimed in claim 1 or 2, which is characterized in that the thickener is selected from sodium acrylate/acryloyl
Dimethyltaurine sodium copolymer and/or xanthan gum.
8. baby's diaper ointment as claimed in claim 1 or 2, which is characterized in that the surfactant is by cetearyl Portugal
Glucosides and laurel alcohol ether phosphate potassium press 1:(0.8~1) weight ratio composition.
9. a kind of method for preparing baby's diaper ointment as described in claim 1~8 is any, which is characterized in that including following step
It is rapid:
A) take zinc oxide, ethylhexyl palmitate, soybean oil, antioxidant and bisabolol in grinding 3-5 times on colloid mill, mistake
180 meshes obtain material I, spare；
B) cetostearyl alcohol, surfactant, emulsifier, dimethyl silicone polymer and stabilizer are added in oily phase pot, heating
To 80~85 DEG C, stirring obtains material II until being completely dissolved, spare；
C) water, moisturizer, thickener, allantoin and EDETATE SODIUM are added in main cooker, 3~5min of homogeneous is allowed to be uniformly dispersed,
It is heated to 80-85 DEG C while stirring, keeps the temperature 10 minutes；
D) material II is pumped into main cooker, 4~8min of homogeneous continuously adds material I, and 3~5min of homogeneous is vacuumized, heat preservation 15
It is cooled to 45 DEG C after~30min, Radix Arnebiae extract, thorn A Gan tree benevolence extract, preservative and essence, stirring to mixing is added
Uniformly；
E) sampling Detection, after the assay was approved filtering and discharging.
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