CN104490747A - Radiation-resistant and photo-protective composition with total-effect defense function and preparation method thereof - Google Patents
Radiation-resistant and photo-protective composition with total-effect defense function and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a radiation-resistant and photo-protective composition with a total-effect defense function and a preparation method thereof. Main components including carboxymethyl glucosan, an extract of spirulina platensis and melittin are combined with plant extraction essences including lithospermum extracting solution and marigold extracting solution, the composition has the double effects of resisting radiation and photoprotection. For radiation, the product is used for effectively alleviating radiation hazards and can be further used for repairing and improving the radiation immunity of a human body in other time. The product disclosed by the invention is good in safety and free of toxic and side effects, and can be used for a long time.
Description
Technical field
The present invention relates to the composition and method of making the same with radioprotective, light protection full effect defense function.
Background technology
Gang of a lot of office always has a question: why not exposed to the weather, skin also can be worse and worse, how to maintain the tired state that skin protection is all difficult to adjust skin? white collars face toward computer more than at least 8 hours every day, and computer radiate directly can cause the disorder of hormonal system, the irregular of skin metabolism.Computer is magnetic, and can build up some dusts and unclean air, and these all can have influence on the quality of skin self, the degree of aging of aggravation skin.So how resist injury?
Life, the work of modern all be unable to do without electrical equipment, especially stay in the white collar of office's working all day, are in for a long time in the electromagnetic radiation environment of the generations such as computer, mobile phone, air-conditioning.Because this radiation be cannot see, can not touch, but inseparable with people's daily life, therefore it is " stealthy killer " person.
Human body is an electric conductor, an inherently biological light current magnetic field, although electromagnetic radiation is colourless, tasteless, invisible, without track, but it can penetrate the many materials comprising human body, for office work crowd, face is exposed in air, contact electromagnetic radiation is inevitable, the heat effect of electromagnetic radiation, non-thermal effect and accumulative effect integrate, and make skin of face exposed for a long time insensitive gradually, produce a large amount of endogenous free radicals, cause lipid peroxidation, cause primary cellular defect, cause xerosis cutis, dark yellow, had a strong impact on skin health.Electromagnetic radiation has become the fourth-largest pollution threatening human health after atmospheric pollution, water pollutions and noise pollution, the scytitis caused by computer and widely using of mobile phone be also current Dermatology, pharmaceutical science and cosmetic science faced by new problem.
Except electromagnetic radiation, the light radiation that computer screen sends also is one of arch-criminal causing scytitis.The light that computer screen sends mainly contains ultraviolet, infrared ray and visible ray.After skin is subject to ultraviolet irradiation, Skin Cell can be caused to injure, produce inflammation.The penetration power of the heat radiation that infrared ray causes to skin exceedes ultraviolet, and 25% ~ 65% of its amount of radiation can arrive epidermis and corium, and 8% ~ 17% can arrive subcutaneous tissue.Infrared ray makes skin temperature raise by thermoradiation efficiency, telangiectasis, congested, increases transepidermal water evaporation etc., directly causes harmful effect to skin.In addition, newest research results shows, visible ray also essence causes dull-looking skin or blackening.For needing the long-term people in the face of computer work, because the electromagnetic radiation of computer, computer screen electromagnetic radiation are to the ionization of air, the adsorption of computer screen to dust in air and the light radiation of computer screen, these radiation sources all damaging of always carving skin.
In recent years, although many chemosynthesis materials have been widely used in radioprotective research, often due to its cytotoxicity or genetoxic, still difficulty has been committed to practical application.Therefore find the attention that natural radioprotective material has caused scholar in the industry, this material should not only have significant antiradiation effect, does not have genetoxic simultaneously, therefore in practical application, have tempting prospect.
At present, most people all uses the method for sun screen to prevent skin radiation by being exposed to outer position in face or other.UV absorbent and ultraviolet light screener is added in sun screen, isolation ultraviolet and radiation protection can be played to a certain extent, but it has certain stimulation to skin, easy blocking pore, remove ornaments and formal dress cumbersome, long-term makeup removing also can not cause the damage of skin only, increases the weight of scytitis.And most commercial sunscreen and sun screen do not provide sufficient visible ray, infrared protection.Need badly in this area and also provide visible ray, infrared ray, radiation proof compositions except ultraviolet protection, for skin sets up a set of perfect system of defense.
Product of the present invention has not only done homework in radioprotective, using Sensor Chip CM 5, spirulina extract, melittin as main component, make full use of the radiation-resistant feature of its high-performance, more combine oligopeptide-1, plant extraction elite (shikonin extract, Flos Tagetis Erectae extracting solution), promote skin defence broad-spectrum light radiation and photoaging repair function, reach the effect of economic benefits and social benefits unification.Product of the present invention uses when in the face of radiation (comprising electromagnetic radiation and light radiation) effectively can alleviate radiation hazradial bundle, uses and can also carry out the radiation immunity power repairing or improve human body self, accomplished radioprotective anywhere or anytime in all the other time.It can make need not the reset protection of armor of people enjoy modern civilization, calm in the face of multiple radiation, is the healthy generous gift of portion of dedicating IT personage, white collar clan, online friend, contact radiation crowd to.
Summary of the invention
The object of the present invention is to provide and a kind of there is the skin care compositions that radioprotective and light protect effect, play the stop to light radiation, electromagnetic radiation, protection and repair.
The technical solution used in the present invention is:
There is the compositions of radioprotective, light protection full effect defense function, composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 6.0-10.0%,
B phase materials:
C phase materials:
D phase materials:
A phase materials:
Deionized water surplus
Glycerol 6.5-8.8%,
B phase materials:
C phase materials:
D phase materials:
Oligopeptide-1 0.02-0.05%,
Phenoxyethanol 0.5-1.0%,
Melittin 0.01-0.05%.
Preferably, said composition is composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 7.0%,
B phase materials:
C phase materials:
D phase materials:
Oligopeptide-1 0.04%,
Phenoxyethanol 0.7%,
Melittin 0.02%.
Preferably, said composition is composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 7.5%,
B phase materials:
C phase materials:
D phase materials:
Oligopeptide-1 0.04%,
Phenoxyethanol 0.6%,
Melittin 0.02%.
Above-mentioned have radioprotective, the full preparation method of imitating the compositions of defense function of light protection, comprises the steps:
1) each component material is weighed by weight percentage;
2), after A phase materials being mixed, add in aqueous phase pot, be heated to 80 DEG C-85 DEG C, constant temperature sterilizing 30 minutes;
3) B phase materials is added in oil phase pot, be heated with stirring to 70 DEG C-75 DEG C, insulation dissolving 20 minutes;
4) under-0.08MPa vacuum stirring state, the material of 1/4-1/2 in aqueous phase pot is evacuated in emulsifying pot, then material whole in oil phase pot is evacuated in emulsifying pot, stir, then leftover materials in aqueous phase pot are evacuated in emulsifying pot, 75 DEG C-78 DEG C homogenizing 3-5 minute;
5) in pot to be emulsified, temperature of charge is cooled to 40 DEG C-45 DEG C, adds C phase materials, stirs;
6) in pot to be emulsified, temperature of charge is cooled to 28 DEG C-32 DEG C, adds D phase materials, discharging after stirring.
Preferably, step 2) in, constant temperature sterilizing 25-35 minute.
Preferably, step 4) in, stir under lower than-0.08MPa vacuum condition.
The invention has the beneficial effects as follows:
The present composition is using Sensor Chip CM 5, spirulina extract, melittin as main component; make full use of the radiation-resistant feature of its high-performance; and in conjunction with shikonin extract, Flos Tagetis Erectae extracting solution plant extraction elite, oligopeptide-1; promote skin defence broad-spectrum light radiation and photoaging repair function, reach the effect of radioprotective and the unification of light protection economic benefits and social benefits.Product of the present invention uses when in the face of radiation (comprising electromagnetic radiation and light radiation), effectively can alleviate radiation hazradial bundle, uses also can carry out the radiation immunity power repairing or improve human body self in all the other time.Product Safety of the present invention is good, has no side effect, can life-time service.
Detailed description of the invention
The present composition mainly comprises following active component: Sensor Chip CM 5, shikonin extract, spirulina extract, Flos Tagetis Erectae extracting solution, Ectoin, melittin, oligopeptide-1.
Sensor Chip CM 5: Sensor Chip CM 5 is that yeast β-1,3-D-glucosan is prepared by derivatization modification, soluble in water, can be compatible with most of cosmetic composition, has good dispersibility, stable in properties.Sensor Chip CM 5 comes from natural raw material, avirulence, nonirritant, and it has following biological activity: high-efficient anti-radiation, uvioresistant, provides skin to resist the tolerance of environmental stimuli; There is film property, skin can be helped to keep moisture, have moisture-keeping efficacy concurrently; Antioxidation, scavenging free radicals, significantly reduce wrinkle of skin, improves skin elasticity; Promote body reparation, wound healing.Sensor Chip CM 5 makes an addition in cosmetic/skin care compositions, can promote compositions radioprotective and after-sun restorative, improves the moisture retention of skin and the smoothness that compacts.
Shikonin extract: be rich in the compositions such as Radix Arnebiae (Radix Lithospermi) Soviet Union, iso-alkannin in shikonin extract, structure belongs to naphthoquinone class.This extracting solution can infiltrate in skin, and have effects such as promoting skin regeneration, Cress, Glycerin, shikonin has been widely used in medicine, cosmetics and printing and dyeing industry as natural pigment.Research finds, the natural material being rich in naphthoquinone can provide the broad-spectrum light of enhancing to protect in visible-range.Inventor in the composition composite enter shikonin extract, to provide efficient visible ray safeguard function.
Spirulina extract: to be that a kind of ancient protokaryon is thread put oxygen cyanophyceae to spirulina (Spirulina) is also the maximum economic microalgae of Present Global exploitation scale.Spirulina has superpower ionizing radiation-resistant ability, and spirulina polysaccharide can significantly improve the physiologically active of other biological opposing ionizing radiation such as Semen Viciae fabae and mice simultaneously.Spirulina metabolism amplitude reduces, and bioavailability is high, and side effect is relatively little.
Ectoin (Ectoin): skin has from the protection belonged to and repairs mechanism; in external pressure; such as UV radiation or heat are with under other physical chemistry pressure; the Skin Cell of human body can produce heat shock protein (HSP; the important tool of cytoprotective and reparation Denatured protein), help wrecking of the Skin Cell defence ambient pressure factor.When defense function start faster, it is better that these press factors just can be dealt with by cell.In order to reach effect of actively antagonism infrared radiation, the present invention by add in the composition Ectoin (
ectoin) accelerate the startup of this defense function, thus excite natural protection ability and the self-repairing capability of skin cell, allow skin escape injury.
Flos Tagetis Erectae extracting solution: the carotenoid (phylloxanthin) be rich in Flos Tagetis Erectae extracting solution has splendid antioxidant activity; breath ultraviolet of can quenching penetrates epidermis, corium; visible ray penetrates into the free radical that deep dermis produces; reach the effect protecting and safeguard Skin Cell; and have and resist light radiation and photoaging repair, strengthen the ability of the inherent and external dual infringement of skin protection.
Melittin: Venenum apis can stimulate and conditioner body immunity function, strengthens the phagocytosis of macrophage, removes the free radical that radiation produces, and anti-lipid peroxidation reacts, thus alleviates radiation damage.Replace full Venenum apis not only to have preventive effect to radiation with melittin, and also have therapeutical effect, highly purified melittin can significantly improve antiradiation effect, and the molecule of melittin is little, and immunogenicity is low, not easily produces anaphylaxis.
Oligopeptide-1: recombinant human epidermal growth factor (rhEGF), epidermal growth factor has multiple important physiological function, reparation and the regeneration of cell can be promoted, can promote the growth of skin, cornea, mucosal tissue, the repair in trauma for the repair in trauma of skin, cornea tissue, ontogeny and internal organs all plays a very important role.All be widely used in the field such as clinical medicine, beauty and skin care.For the boundary that improves looks: repair damaged skin fast, and improve reparation, the nursing of skin: calm down eye wrinkle-removing, firm skin, the mean age of skin histology is reduced, skin care, strengthen skin elasticity: whitening and speckle dispelling, reduce the content of melanin and coloured corpuscle in Skin Cell, accelerate melanocyte metabolism to come off: sun-proof and reparation after shining, alleviate the injury of ultraviolet radiation to skin, reduce the black speck growth of skin after shining: anti-acne, remove cicatrix, shorten the wound healing time and reduce cicatrization, having good effect to preventing and nursing acne.
Below in conjunction with embodiment, set forth content of the present invention further.
Embodiment
Table 1 present composition formula (percentage by weight % amounts to 100%)
Prepare compositions 1 ~ 7 according to formula shown in table 1, preparation method is as follows:
1) each component material is weighed by weight percentage;
2), after A phase materials being mixed, add in aqueous phase pot, be heated to 80 DEG C-85 DEG C, constant temperature sterilizing 25-35 minute;
3) added in oil phase pot by B phase materials, be heated with stirring to 70 DEG C-75 DEG C, insulation is dissolved;
4) lower than under-0.08MPa vacuum stirring state, the material of 1/4-1/2 in aqueous phase pot is evacuated in emulsifying pot, then material whole in oil phase pot is evacuated in emulsifying pot, stir, then leftover materials in aqueous phase pot are evacuated in emulsifying pot, 70 DEG C-80 DEG C homogenizing 3-5 minute;
5) in pot to be emulsified, temperature of charge is cooled to 40-45 DEG C, adds C phase materials, stirs;
6) in pot to be emulsified, temperature of charge is cooled to 28 DEG C-32 DEG C, adds D phase materials, and discharging after stirring, to obtain final product.
Test example 1
Choose healthy volunteer 135 people, male 41 people, women 94 people, age 20-48 year, facial NAI, do not use hormone medicine, do not smear external preparation.Be divided into 9 groups at random, often organize 15 people.Matched group does not smear any skin-protection product, and experimental group 1 uses certain brand sunscreen cream commercially available, and experimental group 3-9 uses embodiment of the present invention compositions 1-7 respectively.At sun-drenched 10:00-12:00 in August, outdoor activity 2 hours.As a result, matched group 15 application on human skin all has shines red phenomenon, observes and all have tanned phenomenon after 24 hours; In experimental group 1, the skin of 13 people does not shine red phenomenon, and 2 people have solarization to a certain degree red, and observing 1 application on human skin after 24 hours has tanned phenomenon, and 1 people has anaphylaxis; In 90 people of experimental group 3-9,4 people have solarization to a certain degree red, and observing only 2 application on human skin after 24 hours has tanned phenomenon, all without anaphylaxis.The above results shows, the present composition has excellent sun-proof function.
Test example 2
Choose volunteer 100 people, 23-38 year, male 25 people, women 75 people, facial NAI, without acne, does not use hormone medicine, and every day is in the face of computer work 6-10 hour.Volunteer is divided at random blank group, a group, b group, c group totally 4 groups, a group uses compositions 5, b group to use compositions 6, c group use compositions 7.After cleaning face morning, after smearing large precious emulsion, smear the present composition; Blank group only smears large precious emulsion.Test period is 30 days, and duration of test keeps normal daily schedule and normal diet.After experiment terminates, observe each volunteer's face skin state, relative to blank group, a, b, c group all significantly improves dark yellow, a red situation of skin, shows that the present composition effectively can defend computer radiate.
Test example 3
Choose volunteer 20 people, be divided into 4 groups at random: blank group is left intact; 3 experimental grouies, spread upon on the skin in arm humerus region by appropriate compositions 4,6,7 respectively; Then, after using infrared lamp (125W) to irradiate arm humerus region 10min with the distance of 60cm respectively, use precision thermometer to measure tested skin temperature, measurement result is in table 2.
Front and back recipient site variations in temperature tested by table 2
| Before infrared radiation (DEG C) | After infrared radiation (DEG C) | |
| Blank group | 30.0 | 36.4 |
| Compositions 4 | 30.0 | 34.9 |
| Compositions 6 | 29.9 | 34.2 |
| Compositions 7 | 30.2 | 33.9 |
。
From table 2, when putting on skin by infrared ray, be coated with the skin temperature ascensional range of the present composition relatively lower than untreated skin.Visible, the infrared ray causing temperature to rise effectively is blocked, that is, the present composition has the effect resisting infrared radiation.
Claims (7)
1. there is the compositions of radioprotective, light protection full effect defense function, composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 6.0-10.0%,
B phase materials:
Butyrospermum Parkii Oil 1.0-3.0%,
Fructus oleae europaeae fruit oil 1.0-5.0%,
Stereth-21 0.5-3.5%,
Stereth-2 1.0-2.5%,
Cera Flava 1.0-4.0%,
Stearic acid 0.5-2.0%,
MBBT 2.0-8.0%,
Vitamin E 0.05-1.0%,
Polydimethylsiloxane 1.0-6.3%,
Cetyl dimethicone 1.0-4.9%,
C phase materials:
Hyaluronic acid 0.01-0.1%,
Folium Mori extract 1.0-3.0%,
Sensor Chip CM 5 1.0-8.0%,
Spirulina extract 4.0-6.0%,
Shikonin extract 1.0-3.0%,
Flos Tagetis Erectae extract 0.01-0.3%,
Ectoin 0.002-0.01%,
D phase materials:
Oligopeptide-1 0.02-0.05%,
Phenoxyethanol 0.5-1.0%,
Melittin 0.01-0.05%.
2. compositions according to claim 1, is characterized in that: composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 6.5-8.8%,
B phase materials:
Butyrospermum Parkii Oil 1.0-3.0%,
Fructus oleae europaeae fruit oil 2.5-5.0%,
Stereth-21 1.0-3.0%,
Stereth-2 1.0-2.0%,
Cera Flava 1.5-3.8%,
Stearic acid 1.0-2.0%,
MBBT 2.0-4.0%,
Vitamin E 0.3-0.8%,
Polydimethylsiloxane 1.6-4.5%,
Cetyl dimethicone 1.5-3.6%,
C phase materials:
Hyaluronic acid 0.04-0.08%,
Folium Mori extract 1.0-3.0%,
Sensor Chip CM 5 3.5-7.5%,
Spirulina extract 4.0-6.0%,
Shikonin extract 1.0-3.0%,
Flos Tagetis Erectae extract 0.08-0.25%,
Ectoin 0.003-0.08%,
D phase materials:
Oligopeptide-1 0.02-0.05%,
Phenoxyethanol 0.5-1.0%,
Melittin 0.01-0.05%.
3. compositions according to claim 1, is characterized in that: composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 7.0%,
B phase materials:
Butyrospermum Parkii Oil 2.5%,
Fructus oleae europaeae fruit oil 3.5%,
Stereth-21 2.5%,
Stereth-2 2.0%,
Cera Flava 2.0%,
Stearic acid 1.0-2.0%,
MBBT 3.5%,
Vitamin E 0.5%,
Polydimethylsiloxane 3.0%,
Cetyl dimethicone 3.0%,
C phase materials:
Hyaluronic acid 0.05%,
Folium Mori extract 2.0%,
Sensor Chip CM 5 5.0%,
Spirulina extract 4.5%,
Shikonin extract 2.5%,
Flos Tagetis Erectae extract 0.15%,
Ectoin 0.006%,
D phase materials:
Oligopeptide-1 0.04%,
Phenoxyethanol 0.7%,
Melittin 0.02%.
4. compositions according to claim 1, is characterized in that: composed of the following components by weight percentage:
A phase materials:
Deionized water surplus
Glycerol 7.5%,
B phase materials:
Butyrospermum Parkii Oil 2.0%,
Fructus oleae europaeae fruit oil 2.5%,
Stereth-21 2.0%,
Stereth-2 1.5%,
Cera Flava 3.5%,
Stearic acid 1.5%,
MBBT 3.0%,
Vitamin E 0.5%,
Polydimethylsiloxane 3.0%,
Cetyl dimethicone 3.0%,
C phase materials:
Hyaluronic acid 0.05%,
Folium Mori extract 2.5%,
Sensor Chip CM 5 4.0%,
Spirulina extract 5.0%,
Shikonin extract 2.0%,
Flos Tagetis Erectae extract 0.2%,
Ectoin 0.005%,
D phase materials:
Oligopeptide-1 0.04%,
Phenoxyethanol 0.6%,
Melittin 0.02%.
5. the preparation method of compositions with radioprotective, light protection full effect defense function described in claim 1-4 any one, comprises the steps:
Weigh each component material by weight percentage;
After A phase materials is mixed, add in aqueous phase pot, be heated to 80 DEG C-85 DEG C, constant temperature sterilizing 30 minutes;
B phase materials is added in oil phase pot, is heated with stirring to 70 DEG C-75 DEG C, insulation dissolving 20 minutes;
Under-0.08MPa vacuum stirring state, the material of 1/4-1/2 in aqueous phase pot is evacuated in emulsifying pot, then material whole in oil phase pot is evacuated in emulsifying pot, stir, then leftover materials in aqueous phase pot are evacuated in emulsifying pot, 75 DEG C-78 DEG C homogenizing 3-5 minute;
In pot to be emulsified, temperature of charge is cooled to 40 DEG C-45 DEG C, adds C phase materials, stirs;
In pot to be emulsified, temperature of charge is cooled to 28 DEG C-32 DEG C, adds D phase materials, discharging after stirring.
6. preparation method according to claim 5, is characterized in that: step 2) in, constant temperature sterilizing 25-35 minute.
7. preparation method according to claim 5, is characterized in that: in step 4), stirs under lower than-0.08MPa vacuum condition.
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| CN114525319A (en) * | 2022-03-11 | 2022-05-24 | 杭州优玛达生物科技有限公司 | Heat shock protein-ectoin composition and preparation method and application thereof |
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| CN106420445A (en) * | 2016-09-19 | 2017-02-22 | 广东丸美生物技术股份有限公司 | Skin care matrix with moisture preserving and oxidation resisting effects as well as preparation method and application of skin care matrix |
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| CN112870122A (en) * | 2021-01-29 | 2021-06-01 | 科丝美诗(中国)化妆品有限公司 | High-stability nano emulsion with light protection effect and preparation method thereof |
| CN112870122B (en) * | 2021-01-29 | 2023-04-07 | 科丝美诗(中国)化妆品有限公司 | High-stability nano emulsion with light protection effect and preparation method thereof |
| CN114525319A (en) * | 2022-03-11 | 2022-05-24 | 杭州优玛达生物科技有限公司 | Heat shock protein-ectoin composition and preparation method and application thereof |
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