CN109498543B

CN109498543B - Composition capable of adjusting skin microecological balance, application thereof, skin lotion containing composition and preparation method of skin lotion

Info

Publication number: CN109498543B
Application number: CN201910015398.9A
Authority: CN
Inventors: 张军; 詹结钫; 张艳红; 陈庆; 杨恒雪
Original assignee: Guangzhou Starriss Technology Co ltd
Current assignee: Guangzhou Starriss Technology Co ltd
Priority date: 2019-01-07
Filing date: 2019-01-07
Publication date: 2021-09-24
Anticipated expiration: 2039-01-07
Also published as: CN109498543A

Abstract

The invention provides a composition capable of adjusting skin microecological balance, application thereof, a skin lotion containing the composition and a preparation method of the skin lotion, and relates to the technical field of cosmetics. The composition capable of regulating the skin microecological balance mainly comprises a white ginseng mushroom extract, a probiotic metabolite and pearl oyster meat antioxidant peptides. The composition prepared by compounding the components has good anti-allergy, anti-inflammation and damaged cell repairing effects, and can increase the number of skin beneficial bacteria, inhibit the growth of harmful bacteria, and remove active oxygen free radicals on the surface of the skin, thereby helping to solve the skin problem caused by skin micro-ecological imbalance, enabling the skin to be smooth, bright and white, and keeping youth forever.

Description

Composition capable of adjusting skin microecological balance, application thereof, skin lotion containing composition and preparation method of skin lotion

Technical Field

The invention relates to the technical field of cosmetics, in particular to a composition capable of adjusting skin micro-ecological balance, application thereof, and a skin lotion containing the composition and a preparation method of the skin lotion.

Background

Skin aging is a phenomenon of skin aging caused by natural factors or non-natural factors. After birth, the skin tissue of a person is increasingly developed, the function of the person is gradually activated, and the person starts to degenerate when the person reaches a certain age, and the degeneration is usually carried out slowly and unconsciously by the person, is a continuous and gradual physiological process and directly influences the appearance and the function of the skin.

Under normal conditions, a large number of microorganisms exist on the surface of the skin, including bacteria, fungi, viruses, chlamydia, certain protozoa and the like, the microbial flora forms a microecological system similar to an ecosphere, and different strains are mutually dependent and restricted to form a unique ecological structure, namely the normal microbial flora of the skin. According to the research of skin microecology, the skin resident bacteria have the effect of occupying space and protecting, and are orderly planted on the skin like a biological barrier, so that the pathogenic bacteria and the foreign bacteria can not stand on the skin. However, long-term, repeated and excessive internal and external environmental stimulation acts on the skin, and when the compensation capacity of the skin is exceeded, the ecological balance of the skin is broken, so that various skin diseases are caused.

Most of the existing cosmetics on the market are designed artificially, although the effect is good, the cosmetics often contain various components harmful to human bodies, such as heavy metals, hormones and the like, the effects of the cosmetics are mostly limited to moisture retention, whitening and the like, and dependence and damage to the bodies can be caused after long-term use. In view of the above, it is necessary and urgent to develop a cosmetic capable of regulating the skin micro-ecological balance, regulating the skin condition, and helping to solve the skin problems caused by the skin micro-ecological imbalance.

In view of the above, the present invention is particularly proposed.

Disclosure of Invention

The composition is prepared by compounding a white ginseng fungus extract, a probiotic metabolite and pearl oyster meat antioxidant peptide, can increase the number of skin beneficial bacteria, inhibit the growth of harmful bacteria and remove active oxygen free radicals on the surface of skin while keeping moisture and resisting oxidation, and further helps to solve the problem of skin caused by skin microecological imbalance, so that the skin is smooth, bright and white and is kept youthful for a long time.

The second purpose of the present invention is to provide an application of the composition for regulating the skin micro-ecological balance, which can be widely applied in the preparation process of whitening cosmetics.

The third purpose of the invention is to provide the skin lotion which is further prepared from the composition capable of regulating the microecological balance of the skin and acceptable auxiliary agents in cosmetics.

The fourth purpose of the invention is to provide a preparation method of the skin lotion, which has simple processing technology, does not need complex processing steps in the preparation process and is suitable for large-scale production and preparation.

The invention provides a composition capable of adjusting skin microecological balance, which is mainly prepared from the following components in parts by weight: 20-30 parts of a white ginseng fungus extract, 5-10 parts of a probiotic metabolite and 5-10 parts of pearl oyster meat antioxidant peptides.

Further, the composition is mainly prepared from the following components in parts by weight: 22-28 parts of a white ginseng fungus extract, 8-10 parts of a probiotic metabolite and 8-10 parts of pearl oyster meat antioxidant peptide;

preferably, the composition is mainly prepared from the following components in parts by weight: 25 parts of a white ginseng fungus extract, 8 parts of a probiotic metabolite and 8 parts of pearl oyster meat antioxidant peptides.

Furthermore, the composition also comprises 2-6 parts of tocopherol acetate.

The invention provides an application of a composition capable of regulating the microecological balance of skin in preparing whitening cosmetics.

Further, the whitening cosmetic is one of a skin lotion, a facial cleanser, a skin lotion, a facial mask and essential oil.

The skin lotion provided by the invention comprises the composition capable of adjusting the microecological balance of the skin and an acceptable auxiliary agent in cosmetics;

preferably, the adjuvants include emollients, humectants, emulsifiers, emulsion stabilizers, thickeners, skin conditioning agents, preservatives and fragrances.

Further, the skin moistening lotion is mainly prepared from the following components in percentage by weight: 3-8% of the composition capable of adjusting the skin microecological balance, 7-25% of an emollient, 1-10% of a humectant, 1.5-4% of an emulsifier, 1-10% of an emulsion stabilizer, 0.5-1.5% of a thickener, 8-20% of a skin conditioner, 0-1% of a preservative, 0-1% of an aromatizer and the balance of deionized water, wherein the total amount is 100%;

preferably, the skin lotion is mainly prepared from the following components in percentage by weight: 4-6% of the composition capable of adjusting the skin microecological balance, 8-20% of an emollient, 1-5% of a humectant, 2-3.5% of an emulsifier, 1-5% of an emulsion stabilizer, 0-1% of a thickening agent, 10-17% of a skin conditioner, 0-1% of a preservative, 0-1% of an aromatizer and the balance of deionized water, wherein the total amount is 100%;

more preferably, the skin lotion is mainly prepared from the following components in percentage by weight: the composition capable of adjusting the microecological balance of the skin comprises 5% of the composition, 15% of an emollient, 3% of a humectant, 2% of an emulsifier, 2% of an emulsion stabilizer, 1% of a thickening agent, 15% of a skin conditioner, 1% of a preservative, 1% of an aromatizing agent and the balance of deionized water, and the total amount is 100%.

Further, the emollient is one or a mixture of more of silk oil, shea butter, spanish nut oil, isononyl isononanoate, silicone oil and tocopherol acetate;

the humectant is one or a mixture of more of glycerol, propylene glycol, 1, 2-butanediol, 1, 2-hexanediol and sorbitol;

the emulsifier is APG emulsifier or C12-20 alkyl glucoside;

the emulsion stabilizer is 16-18 alcohol;

the thickening agent is hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, or the mixture of sodium acrylate/acryloyl dimethyl taurate copolymer and isohexadecane, polysorbate-60, or the mixture of sodium acrylate/acryloyl dimethyl taurate copolymer, isohexadecane, polysorbate-80;

the skin conditioner is a lysate of a yeast fermentation product of the yeast schizolysis.

The invention provides a preparation method of skin lotion, which comprises the following steps:

firstly, preparing a humectant and water at 75-85 ℃ to obtain an aqueous phase solution, simultaneously mixing an emollient, an emulsifier, an emulsion stabilizer and a thickening agent to prepare an oil phase solution, then mixing the aqueous phase solution and the oil phase solution, homogenizing for 3-8 min, cooling to 35-45 ℃, adding a skin conditioner, a preservative and an aromatizing agent, and uniformly stirring to obtain the skin lotion.

Further, the preparation method further comprises the step of sterilizing the aqueous phase solution and the oil phase solution before mixing the aqueous phase solution and the oil phase solution;

preferably, the sterilization step is to heat the water phase solution and the oil phase solution to 80-90 ℃ and treat for 30-40 min.

Compared with the prior art, the invention has the beneficial effects that:

the composition capable of regulating the microecological balance of skin mainly comprises a white ginseng extract, a probiotic metabolite and pearl oyster meat antioxidant peptides. The white ginseng fungus extract is rich in Schizophyllan (SPG) and other components, has strong glucan activity, and has good anti-allergy, anti-inflammation and damaged cell repairing effects when being applied to a composition for regulating the ecological balance of skin; the metabolite of the probiotics has good moisturizing effect and can promote the metabolism of the skin, meanwhile, the metabolite of the probiotics contains a large amount of acidic substances, and harmful bacteria do not like the acidic environment, so that the growth of the harmful bacteria can be inhibited, and the metabolite of the probiotics also has the effects of removing acne cutin, reviving the skin and brightening the skin; the pearl oyster meat antioxidant peptide has very strong antioxidant activity, and can effectively remove active oxygen free radicals on the surface of skin, so that the skin activity is improved, and the skin aging is delayed. The composition prepared by compounding the white ginseng fungus extract, the probiotic metabolite and the pearl oyster meat antioxidant peptide can increase the number of skin beneficial bacteria, inhibit the growth of harmful bacteria and clear active oxygen free radicals on the surface of skin while resisting allergy, diminishing inflammation and repairing damaged cells, so that the skin problem caused by skin micro-ecological imbalance is solved, and the skin is smooth, bright and white and is kept youthful for a long time.

The composition capable of adjusting the microecological balance of the skin can be widely applied to the preparation process of whitening cosmetics.

The skin lotion provided by the invention comprises the composition capable of adjusting the skin micro-ecological balance and acceptable auxiliaries in cosmetics, and the skin lotion prepared from the components has the effects of moisturizing, resisting oxidation and the like, can also adjust the skin micro-ecological balance environment, increase the number of skin beneficial bacteria, inhibit the growth of harmful bacteria, further help solve the skin problem caused by skin micro-ecological imbalance, and enable the skin to be smooth, bright and white and keep youth for a long time.

The preparation method of the skin moisturizing emulsion comprises the steps of firstly preparing a humectant with water to obtain an aqueous phase solution, simultaneously mixing the emollient, an emulsifier, an emulsion stabilizer and a thickening agent to obtain an oil phase solution, then mixing the aqueous phase solution and the oil phase solution, homogenizing for 3-8 min, cooling to 35-45 ℃, adding a skin conditioner, a preservative and an aromatizing agent, and uniformly stirring to obtain the skin moisturizing emulsion. The preparation method has simple processing technology, does not need complex processing steps in the preparation process, and is suitable for large-scale production and preparation.

Detailed Description

In the present invention, all the embodiments and preferred methods mentioned herein can be combined with each other to form a new technical solution, if not specifically stated.

In the present invention, all the technical features mentioned herein and preferred features may be combined with each other to form a new technical solution, if not specifically stated.

In the present invention, the percentage (%) or parts means the weight percentage or parts by weight with respect to the composition, if not otherwise specified.

In the present invention, the components referred to or the preferred components thereof may be combined with each other to form a novel embodiment, if not specifically stated.

In the present invention, unless otherwise stated, the numerical range "a-b" represents a shorthand representation of any combination of real numbers between a and b, where a and b are both real numbers. For example, a numerical range of "6 to 22" means that all real numbers between "6 to 22" have been listed herein, and "6 to 22" is simply a shorthand representation of the combination of these values.

The "ranges" disclosed herein may have one or more lower limits and one or more upper limits, respectively, in the form of lower limits and upper limits.

In the present invention, unless otherwise specified, the individual reactions or operation steps may be performed sequentially or may be performed in sequence. Preferably, the reaction processes herein are carried out sequentially.

Unless otherwise defined, technical and scientific terms used herein have the same meaning as is familiar to those skilled in the art. In addition, any methods or materials similar or equivalent to those described herein can also be used in the present invention.

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

According to one aspect of the invention, the composition capable of regulating the microecological balance of skin is mainly prepared from the following components in parts by weight: 20-30 parts of a white ginseng fungus extract, 5-10 parts of a probiotic metabolite and 5-10 parts of pearl oyster meat antioxidant peptides.

The skin conditioning composition of the present invention has the following effects:

white ginseng fungus extract: the white ginseng fungus extract is extracted from Yunnan wild white ginseng fungus and is rich in Schizophyllan (SPG) and other components. In 1978, Baimukuv et al reported that a polysaccharide (SPG) extracted from a Schizophyllum commune culture solution in Basidiomycetes has the effects of promoting cellular immunity and inhibiting mouse sarcoma S-180, and has a certain curative effect on lung cancer, digestive tract cancer and chronic hepatitis. The extract of the white ginseng bacterium extract is rich in SPG, the effect of the conventional glucan is generally moisture preservation even if the conventional glucan is used in cosmetics, but the anti-allergy, anti-inflammation and damaged cell repair effects are not obvious, the white ginseng bacterium extract has the strongest biological activity of beta- (1-3) -D-glucan with the branching Degree (DB) of 0.2-0.33 degrees due to the unique triple helix structure (the beta-1, 3 glycosidic bond is used as a main chain, and each three glucose units have one glucose branch connected by the beta-1, 6 glycosidic bond) of the SPG. The SPG has a branching degree of 0.33, a molecular weight range of between active ranges, is soluble in water, and has anti-allergy, anti-inflammatory and damaged cell repairing effects when applied to a composition for regulating skin ecological balance. Meanwhile, the skin micro-ecological balance environment can be adjusted by matching with metabolites of the probiotics, the quantity of the beneficial bacteria in the skin is increased, and the growth of harmful bacteria is inhibited.

As a preferred embodiment, the extract of the white ginseng mushroom of the present invention is obtained by water extraction and alcohol precipitation or by water extraction and alcohol precipitation after alkali treatment, and the specific extraction method is described in detail in the 12 th stage of Shizhen national medicine published in 2001, and will not be described herein again.

Metabolites of probiotics: the metabolite of the probiotics is rich in polysaccharide, bacteriocin, lactic acid and other substances, has hydrophilicity and good moisturizing effect, and can promote the metabolism of the skin, so that the effect of lubricating the skin is achieved, meanwhile, a large amount of acidic substances exist in the metabolite of the probiotics, and harmful bacteria do not like an acidic environment, so that the growth of the harmful bacteria can be inhibited, and the metabolite of the probiotics also has the effects of removing acne cutin, and brightening the skin.

As a preferred embodiment, the probiotic metabolite of the present invention is a bifidobacterium metabolite. Preferably, the bifidobacterium is at least one or more of bifidobacterium bifidum, bifidobacterium adolescentis, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve and mixture thereof

Pearl oyster meat antioxidant peptide: the pearl oyster meat antioxidant peptide has very strong antioxidant activity and hydroxyl radical scavenging capacity, can effectively scavenge excessive active oxygen radicals in vivo, and protects normal structures and functions of cells and mitochondria. The pearl oyster meat antioxidant peptide is applied to the composition for regulating the ecological balance of the skin, so that the active oxygen free radicals on the surface of the skin can be effectively eliminated, the skin vitality is improved, and the skin aging is delayed.

The composition capable of regulating the microecological balance of skin mainly comprises a white ginseng extract, a probiotic metabolite and pearl oyster meat antioxidant peptides. The white ginseng fungus extract is rich in Schizophyllan (SPG) and other various components, has strong glucan activity, and has good anti-allergy, anti-inflammation and damaged cell repairing effects while being applied to the composition for regulating the ecological balance of skin and having the effects of moisture preservation and oxidation resistance; the metabolite of the probiotics has good moisturizing effect and can promote the metabolism of the skin, meanwhile, the metabolite of the probiotics contains a large amount of acidic substances, and harmful bacteria do not like the acidic environment, so that the growth of the harmful bacteria can be inhibited, and the metabolite of the probiotics also has the effects of removing acne cutin, reviving the skin and brightening the skin; the pearl oyster meat antioxidant peptide has very strong antioxidant activity, and can effectively remove active oxygen free radicals on the surface of skin, so that the skin activity is improved, and the skin aging is delayed. The composition prepared by compounding the white ginseng fungus extract, the probiotic metabolite and the pearl oyster meat antioxidant peptide can increase the number of skin beneficial bacteria, inhibit the growth of harmful bacteria and clear active oxygen free radicals on the surface of skin while resisting allergy, diminishing inflammation and repairing damaged cells, so that the skin problem caused by skin micro-ecological imbalance is solved, and the skin is smooth, bright and white and is kept youthful for a long time.

As a preferred embodiment, typical but non-limiting preferred embodiments of the above white ginseng fungus extract are: 20 parts, 22 parts, 25 parts, 28 parts and 30 parts; typical but non-limiting preferred embodiments of the above probiotic metabolites are: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts; typical but non-limiting preferred embodiments of the above-mentioned pearl oyster meat antioxidant peptides are: 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts.

In a preferred embodiment of the present invention, the composition is mainly prepared from the following components in parts by weight: 22-28 parts of a white ginseng fungus extract, 8-10 parts of a probiotic metabolite and 8-10 parts of pearl oyster meat antioxidant peptide;

In the invention, the medicine effect of the composition capable of regulating the skin microecological balance is further optimized by further adjusting and optimizing the dosage proportion of each component raw material in the composition capable of regulating the skin microecological balance.

In the above preferred embodiment, the composition further comprises 2-6 parts of tocopherol acetate.

In a preferred embodiment, the composition further comprises 2-6 parts of tocopherol acetate. Tocophyryl Acetate (also called vitamin E Acetate) is a compound generated by esterification of tocopherol (or vitamin E) and acetic acid, and the tocopherol Acetate is a skin regulator and an antioxidant.

As a preferred embodiment, typical but non-limiting preferred embodiments of the above mentioned tocopheryl acetate are: 2 parts, 3 parts, 4 parts, 5 parts and 6 parts.

According to one aspect of the invention, the application of a composition capable of regulating the microecological balance of skin in preparing a whitening cosmetic is provided.

In a preferred embodiment of the present invention, the whitening cosmetic is one of a skin lotion, a facial cleanser, a skin lotion, a mask, and an essential oil.

According to one aspect of the invention, the skin lotion comprises the composition capable of regulating the skin microecological balance and auxiliary agents acceptable in cosmetics;

In a preferred embodiment of the invention, the skin lotion is mainly prepared from the following components in percentage by weight: 3-8% of the composition capable of adjusting the skin microecological balance, 7-25% of an emollient, 1-10% of a humectant, 1.5-4% of an emulsifier, 1-10% of an emulsion stabilizer, 0.5-1.5% of a thickener, 8-20% of a skin conditioner, 0-1% of a preservative, 0-1% of an aromatizer and the balance of deionized water, wherein the total amount is 100%;

In the invention, the effect of regulating the skin micro-ecological environment balance of the skin moisturizing cream is further optimized by further adjusting and optimizing the dosage proportion of the raw materials of each component.

In a preferred embodiment of the invention, the emollient is one or a mixture of silk oil, shea butter, spanish nut oil, isononyl isononanoate, silicone oil and tocopherol acetate;

the emulsifier is APG emulsifier or C12-20 alkyl glucoside;

the emulsion stabilizer is 16-18 alcohol;

the skin conditioner is a lysate of a yeast fermentation product of the yeast schizolysis. The CAS number for the binary fission yeast fermentation product lysate is 96507-89-0. The lysate of the yeast fermentation product of the bifidus is cultured, inactivated and decomposed by bifidobacterium to obtain metabolites, cytoplasmic fragments, cell wall components and polysaccharide complexes. The lysate of the yeast fermentation product has strong immunosuppressive activity and can promote DNA repair, effectively protect skin and avoid damage caused by ultraviolet rays, and meanwhile, the lysate of the yeast fermentation product can also generate small molecules which comprise vitamin B groups, minerals, amino acids and the like and are beneficial to skin care, so that the yeast essence is high-quality yeast essence for skin care. According to the invention, the lysate of the yeast dehiscence yeast fermentation product is added into the skin lotion as a skin conditioner, so that the anti-immunosuppression activity of the skin lotion can be effectively improved, and the skin can be effectively protected.

The antiseptic raw material is one or a mixture of more than two of Zanthoxylum piperitum, Pulsatilla chinensis Benth, Usnea barbata, glyceryl caprylate, caprylyl hydroxamic acid, hexyl ethyl glycerol, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, 1, 3-butanediol, p-hydroxyacetophenone, a herba Menthae extract and epsilon-polylysine;

the aromatizing agent is one of rose hydrosol or peony hydrosol.

According to one aspect of the present invention, a method for preparing a skin lotion, the method comprising the steps of:

In a preferred embodiment of the present invention, the preparation method further comprises the step of sterilizing the aqueous phase solution and the oil phase solution before mixing them;

The technical solution of the present invention will be further described with reference to examples and comparative examples.

Example 1

The skin lotion is prepared from the following components in percentage by weight: 3% of composition capable of adjusting skin microecological balance, 7% of silk oil, 1% of propylene glycol, 1.5% of APG emulsifier, 1% of 16-18 alcohol, 0.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 8% of lysate of yeast fermentation product of bifida, 1% of octyl glycol, 1% of rose hydrosol and the balance of deionized water, wherein the total amount is 100%;

the composition capable of adjusting the microecological balance of the skin is mainly prepared from the following components in parts by weight: 20 parts of a white ginseng fungus extract, 5 parts of a probiotic metabolite and 5 parts of pearl oyster meat antioxidant peptides.

The preparation method of the skin lotion comprises the following steps:

firstly, preparing a humectant and water at 75 ℃ to obtain an aqueous phase solution, simultaneously mixing an emollient, an emulsifier, an emulsion stabilizer and a thickening agent to obtain an oil phase solution, respectively heating the prepared aqueous phase solution and oil phase solution to 80 ℃, sterilizing for 30min, then mixing and homogenizing the aqueous phase solution and the oil phase solution for 3min, then cooling to 35 ℃, adding a skin conditioner, a preservative and an aromatizing agent, and uniformly stirring to obtain the skin lotion.

Example 2

The skin lotion is prepared from the following components in percentage by weight: 8% of composition capable of adjusting skin microecological balance, 25% of silicone oil, 10% of sorbitol, 4% of APG emulsifier, 10% of 16-18 alcohol, 1.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 20% of schizosaccharomyces cerevisiae fermentation product lysate, 1% of peppermint extract, 1% of peony hydrosol and the balance of deionized water, wherein the total amount is 100%;

the composition capable of adjusting the microecological balance of the skin is mainly prepared from the following components in parts by weight: 30 parts of white ginseng fungus extract, 10 parts of probiotic metabolite and 10 parts of pearl oyster meat antioxidant peptide.

The preparation method of the skin lotion comprises the following steps:

firstly, preparing a humectant and water at 85 ℃ to obtain an aqueous phase solution, simultaneously mixing an emollient, an emulsifier, an emulsion stabilizer and a thickening agent to obtain an oil phase solution, respectively heating the prepared aqueous phase solution and oil phase solution to 90 ℃, sterilizing for 40min, then mixing and homogenizing the aqueous phase solution and the oil phase solution for 8min, then cooling to 45 ℃, adding a skin conditioner, a preservative and an aromatizing agent, and uniformly stirring to obtain the skin lotion.

Example 3

The skin lotion is prepared from the following components in percentage by weight: composition capable of regulating skin microecological balance 5%, C12-20 alkyl glucoside 2%, 16-18 alcohol 1%, silk oil 3%, shea butter 2%, isononyl isononanoate 3%, Spanish nut oil 4%, silicone oil 2%, glycerin 5%, sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-600.8%, p-hydroxyacetophenone 0.5%, hexanediol 0.5%, schizosaccharomyces cerevisiae fermentation product lysate 5%, peony hydrosol 0.02%, and balance deionized water, totaling 100%;

the composition capable of adjusting the microecological balance of the skin is mainly prepared from the following components in parts by weight: 22 parts of white ginseng fungus extract, 6 parts of probiotic metabolite, 6 parts of pearl oyster meat antioxidant peptide and 2 parts of tocopherol acetate.

The preparation method of the skin lotion comprises the following steps:

firstly, preparing a humectant and water at 80 ℃ to obtain an aqueous phase solution, simultaneously mixing an emollient, an emulsifier, an emulsion stabilizer and a thickening agent to obtain an oil phase solution, respectively heating the prepared aqueous phase solution and the oil phase solution to 85 ℃, carrying out sterilization treatment for 35min, then mixing and homogenizing the aqueous phase solution and the oil phase solution for 5min, then cooling to 40 ℃, adding a skin conditioner, a preservative and an aromatizing agent, and uniformly stirring to obtain the skin lotion.

Example 4

The skin lotion is prepared from the following components in percentage by weight: composition capable of regulating the microecological balance of the skin 5%, C12-20 alkyl glucoside 2%, 16-18 alcohol 1%, tocopherol acetate 3%, shea butter 2%, isononyl isononanoate 3%, Spanish nut oil 4%, silicone oil 2%, propylene glycol 5%, sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-600.8%, p-hydroxyacetophenone 0.5%, hexanediol 0.5%, yeast schizolysis product 3%, peony hydrosol 0.02%, and the balance of deionized water, totaling 100%;

the composition capable of adjusting the microecological balance of the skin is mainly prepared from the following components in parts by weight: 28 parts of white ginseng fungus extract, 10 parts of probiotic metabolite, 10 parts of pearl oyster meat antioxidant peptide and 5 parts of tocopherol acetate.

The method for preparing the skin lotion of this example is the same as that of example 3.

Example 5

The skin lotion is prepared from the following components in percentage by weight: composition capable of regulating the microecological balance of the skin by 5%, C12-20 alkyl glucoside 2%, 16-18 alcohol 2%, silk oil 3%, shea butter 2%, isononyl isononanoate 3%, Spanish nut oil 2%, silicone oil 2%, glycerin 5%, sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-800.8%, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 0.3%, p-hydroxyacetophenone 0.5%, hexanediol 0.5%, yeast dileakage fermentation product lysate 5%, peony hydrosol 0.02%, and the balance of deionized water, the total being 100%;

the composition capable of adjusting the microecological balance of the skin is mainly prepared from the following components in parts by weight: 25 parts of white ginseng fungus extract, 8 parts of probiotic metabolite, 8 parts of pearl oyster meat antioxidant peptide and 3 parts of tocopherol acetate.

Comparative example 1

This comparative example is the same as example 5 except that the emollient cream component does not contain isononyl isononanoate, spanish nut oil and silicone oil.

Comparative example 2

This comparative example is the same as example 5 except that the emollient milk component does not contain 16-18 alcohol.

Comparative example 3

This comparative example is the same as example 5 except that the emollient milk component does not include glycerin.

Comparative example 4

This comparative example is the same as example 5 except that 1% of the C12-20 alkyl glucoside is present in the emollient milk component.

Comparative example 5

This comparative example is the same as example 5 except that the amount of sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-80 in the emollient milk component was 2%.

Experimental example 1

In order to show that the skin lotion prepared by the invention has a stable formula system, the inventors have tested the stability of the skin lotions prepared in examples 1-5 and comparative examples 1-5, and the results are shown in table 1:

table 1: stability detection results of skin moisturizing creams prepared in embodiments 1-5 and comparative examples 1-5 of the invention

The above table shows that the skin lotion prepared in the embodiments 1 to 5 of the present invention has good stability after standing for 90 days and under high temperature and low temperature environments, and the lotion is clear and not turbid, and does not have any precipitation, separation, oil bleeding, and other phenomena.

The comparative example 1 does not contain the isononyl isononanoate, the Spanish nut oil, the silicone oil and other emollients, the emollients are only the silk oil and the shea butter, account for only 5% of the content of the emollient cream of the invention, and are not within the component content of the emollient of the invention, and the emollient cream prepared by the method has poorer high-temperature stability compared with the emollient cream prepared by the invention of the examples 1 to 5, and the phenomenon of turbidity and dullness of the cream appears after being placed for 24 hours at the temperature of 45 ℃.

Compared with the skin-moistening emulsion prepared in the embodiment 1-5, the skin-moistening emulsion prepared in the comparative example 2 does not contain an emulsion stabilizer, has poor stability after standing for 90 days and under high-temperature and low-temperature environments, and has the phenomena of emulsion turbidity and layered precipitation in the stability detection process.

In comparative example 3, glycerin is not included, the humectant is only hexanediol, the content of the humectant in the skin emulsion is only 0.5%, and the content of the humectant is not within the content of the components of the humectant, so that the skin emulsion prepared by the method is poorer in stability after standing for 90 days and under high temperature conditions, and slight precipitation and oil floating phenomena of the skin emulsion are generated compared with examples 1-5.

Compared with the skin-moistening cream prepared by the embodiment 1-5, the skin-moistening cream prepared by the method has poor stability after standing for 90 days and under high-temperature and low-temperature environments, and has the phenomena of emulsion turbidity and layered precipitation in the stability detection process.

In the comparative example 5, the content of the sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-80 is 2%, the content of the thickener is higher than the component content of the thickener, and compared with the skin-moistening emulsion prepared in the examples 1-5, the skin-moistening emulsion prepared by the method is poor in stability after standing for 90 days and under a high-temperature condition, and the emulsion is turbid and has no luster.

The analysis shows that the skin lotion is a stable formula system formed by scientific and reasonable compatibility, has good stability after standing for 90 days and under the environment of high temperature and low temperature, and has the advantages of clear emulsion, no turbidity, no precipitation, delamination, oil bleeding and the like. Compared with the comparative examples 1-5, the skin lotion prepared by the formula system of the invention has poor stability.

Experimental example 2

In order to show that the formula system of the skin lotion prepared by the invention has good moisturizing and moisturizing performances, the inventors have tested the moisturizing performances of the skin lotions prepared in examples 1 to 5 and comparative examples 1 to 5, and the results are shown in table 2:

the test method comprises the following steps: the female volunteers used the forehead as the test part during the test, and a fixed area with the size of 2 square centimeters is drawn on the forehead of the face as the test area. Moisture content of the skin was measured on the forehead skin of 5 female consumers between 18 and 50 years of age in each group using a Corneometer CM820 skin Moisture meter in an indoor environment at 20 c and 50% relative humidity, and the results were expressed by a set Moisture Measurement Value (MMV) to evaluate the moisturizing performance of the emulsion of the present invention.

Wherein: MMV 1-MMV value of skin before applying essence lotion,

MMV 2-skin MMV value within 1 minute after application of serum,

MMV 3-skin MMV value 1 hour after applying essence lotion.

The water supplement rate is MMV2/MMV1 multiplied by 100 percent;

moisture retention rate is MMV3/MMV2 multiplied by 100%;

table 2: moisturizing performance detection results of moisturizing creams prepared in embodiments 1-5 and comparative examples 1-5 of the invention

From the above table, it can be seen that the moisturizing creams prepared in the embodiments 1 to 5 of the present invention all have a good moisturizing effect, and the moisturizing rates of the moisturizing creams are all above 80%, particularly the moisturizing rate of the moisturizing cream prepared in the embodiment 5 is as high as 87%, and the effect of each embodiment is optimal. In contrast to the skin moisturizing creams prepared in the comparative examples 1 to 5 without the formula system, the skin moisturizing creams have the moisture retention performance of below 80%, which far cannot achieve the moisture retention effect of the examples 1 to 5.

Example 6

This example is the same as example 5 except that tocopherol acetate is not included in the composition for regulating the skin microecological balance.

Comparative example 6

This example is the same as example 5 except that the emollient milk components do not include a composition that can adjust the microecological balance of the skin.

Comparative example 7

This example is the same as example 5 except that the composition for regulating the skin microecological balance does not include the extract of white ginseng fungus.

Comparative example 8

This example is the same as example 5 except that the composition for regulating the skin microecological balance comprises 15 parts of the extract of white ginseng mushroom.

Comparative example 9

This example is the same as example 5 except that the white ginseng fungus extract is replaced with tremella polysaccharide in the composition for regulating the microecological balance of skin.

Comparative example 10

This example is the same as example 5 except that the composition for regulating the microecological balance of skin comprises 3 parts of the probiotic metabolite.

Comparative example 11

This example is the same as example 5 except that the composition for regulating the skin microecological balance does not include the meat antioxidant peptide.

Experimental example 3

In order to show that the skin moisturizing milk prepared by the invention has the effect of regulating the skin micro-ecological balance, namely has the effects of promoting the proliferation of beneficial bacteria (staphylococcus epidermidis and bifidobacterium adolescentis) and inhibiting the proliferation of harmful bacteria (staphylococcus aureus and escherichia coli), laboratory tests are carried out on the skin moisturizing milk prepared in the examples 1-6 and the comparative examples 6-11, and the results are shown in table 3:

the experimental method comprises the following steps: inoculating Staphylococcus epidermidis, Bifidobacterium adolescentis, Staphylococcus aureus and Escherichia coli with glass culture dish and conventional culture medium at an amount of 1 × 10⁵Subsequently, a layer of skin lotion was applied to the inoculated surface, and the colony number was measured after 24 hours.

Table 3: the moisturizing creams prepared in examples 1-6 and comparative examples 6-11 have proliferation and inhibition effects on various bacterial strains.

The above table shows that the skin moisturizing cream prepared in the embodiments 1-5 can effectively promote the proliferation of staphylococcus epidermidis and bifidobacterium adolescentis which are normal flora on skin, has an inhibiting effect on staphylococcus aureus and escherichia coli which are pathogenic bacteria on skin, and has a positive effect on enhancing skin micro-ecology. And the comparative example 6 does not contain the skin moisturizing cream prepared from the composition capable of regulating the skin micro-ecological balance, has no proliferation effect on staphylococcus epidermidis and bifidobacterium adolescentis, has no inhibition effect on staphylococcus aureus and escherichia coli, can not achieve the micro-ecological balance of the skin after being used by a human body, and is easy to cause the symptoms of skin discomfort.

While the skin lotion prepared by the embodiment 6 without containing the tocopherol acetate has poor proliferation effect on staphylococcus epidermidis and bifidobacterium adolescentis compared with the skin lotions prepared by the embodiments 1-5, which shows that the tocopherol acetate is used as an antioxidant and plays a certain role in promoting the growth of beneficial bacteria in the invention.

The comparative example 7 does not include the white ginseng mushroom extract and the comparative example 8 does not include the skin lotion with the content of the white ginseng mushroom extract lower than the component content of the skin lotion, compared with the skin lotion prepared in the examples 1-5, the skin lotion has poor proliferation effects on staphylococcus epidermidis and bifidobacterium adolescentis and poor inhibition effects on staphylococcus aureus and escherichia coli, and the result shows that the white ginseng mushroom extract has high glucan activity, and after the white ginseng mushroom extract and the probiotic metabolite are combined, the skin microecological balance environment can be adjusted, the number of skin beneficial bacteria can be increased, and the growth of harmful bacteria can be inhibited.

In a comparative example 9, compared with the skin lotion prepared in examples 1 to 5, the skin lotion prepared by using tremella polysaccharide instead of the white ginseng extract has a relatively poor proliferation effect on staphylococcus epidermidis and bifidobacterium adolescentis and a relatively poor inhibition effect on staphylococcus aureus and escherichia coli, which indicates that the white ginseng extract used in the invention is rich in various components such as Schizophyllan (SPG), and the like, has relatively strong biological activity of glucan compared with common polysaccharide, and the white ginseng extract applied to the components of the invention has a relatively good effect of increasing the number of beneficial bacteria in skin and inhibiting the growth of harmful bacteria.

Comparative example 10 the probiotic metabolite was 3 parts, and the skin lotion prepared with the probiotic metabolite content lower than the component content of the present invention was also less effective than the skin lotions prepared in examples 1 to 5, and the technical effects of the present invention could not be achieved.

The skin lotion prepared in the comparative example 11 without the pearl oyster meat antioxidant peptides has a slightly poor proliferation effect on staphylococcus epidermidis and bifidobacterium adolescentis and a slightly poor inhibition effect on staphylococcus aureus and escherichia coli compared with the skin lotions prepared in the examples 1 to 5, which shows that the pearl oyster meat antioxidant peptides have a good free radical scavenging effect, are beneficial to maintaining the micro-ecological balance of skin, increase the number of beneficial bacteria in the skin and inhibit the growth of harmful bacteria.

The skin moistening cream prepared by the invention has the effects of moisturizing and resisting oxidation, and meanwhile, the quantity of beneficial bacteria in the skin can be increased, the growth of harmful bacteria can be inhibited, and the active oxygen free radicals on the surface of the skin can be eliminated, so that the skin moistening cream helps to solve the skin problem caused by the micro-ecological imbalance of the skin, and is smooth, bright and white, and can keep youth forever.

Experimental example 4

Currently, 90 facial acne volunteers (30 men and 60 women among the age of 18-25 years) are selected by adopting a poll method, the facial acne volunteers are divided into 9 groups, 10 people in each group are respectively detected by using the skin moisturizing creams prepared in the embodiments 5 and 6 and the comparative examples 6-11 of the invention, the control group adopts a commercially available correction aloe acne removing cream, the skin moisturizing cream is used once every day after cleaning the face in the morning and at night and is continuously used for 30 days, and the results are shown in table 4:

the using effect is comprehensively scored by 10 dermatologists according to the condition of facial skin of volunteers for respectively regulating skin, nourishing and brightening skin, and finally, the evaluation result is obtained by averaging. The scoring standard adopts a score of 5, the score of 5 has obvious effect, the score of 3-4 has better effect, the score of 2-3 has common effect, the score of 0-1 has no obvious effect, and the score of 0 has no effect.

Table 4: results of civil investigations

Group of	Skin conditioning	Nourishing effect	Skin lightening effect
				Example 5	4.2	4	4.1
Example 6	4.1	4.3	3.9
				Comparative example 6	2.3	2.4	1.9
Comparative example 7	2.9	3.1	3.2
				Comparative example 8	2.7	2.9	2.6
Comparative example 9	3.4	3.2	3.3
				Comparative example 10	3.1	2.7	2.8
Comparative example 11	3.9	3.5	3.7
				Control group	2.6	3.1	3.2

As can be seen from the above table, the skin of the skin cream prepared in examples 5 and 6 improves to different degrees, so that the skin cream can effectively improve the skin of the acne patients, repair damaged cells, promote metabolism, and help the damaged skin to heal, and the using effect of the skin cream is obviously better than that of the volunteers who use the commercial correction aloe acne-removing cream for experiments in the control group.

In addition, the inventor also performed irritation and allergic tests on the skin cream prepared in examples 1 to 5, wherein the skin cream prepared in examples 1 to 5 was applied to the area without skin cut by clipping the hair on the back of a white mouse, and the results of the experiments were compared with the areas without skin cut by applying the skin cream prepared in examples 1 to 5.

In conclusion, the composition capable of regulating the skin microecological balance mainly comprises the white ginseng mushroom extract, the probiotic metabolite and the pearl oyster meat antioxidant peptide. The composition prepared by compounding the components has the effects of moisturizing and resisting oxidation, and can increase the number of skin beneficial bacteria, inhibit the growth of harmful bacteria, and remove active oxygen radicals on the surface of the skin, so that the composition helps to solve the skin problem caused by skin microecological imbalance, and the skin is smooth, bright and white and is kept youthful forever.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. The skin lotion is prepared from the following components in percentage by weight: 3% of composition capable of adjusting skin microecological balance, 7% of silk oil, 1% of propylene glycol, 1.5% of APG emulsifier, 1% of 16-18 alcohol, 0.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 8% of lysate of yeast fermentation product of bifida, 1% of octyl glycol, 1% of rose hydrosol and the balance of deionized water, wherein the total amount is 100%; the composition capable of adjusting the microecological balance of the skin is prepared from the following components in parts by weight: 20 parts of a white ginseng fungus extract, 5 parts of a probiotic metabolite and 5 parts of pearl oyster meat antioxidant peptides.

2. The skin lotion is prepared from the following components in percentage by weight: 8% of composition capable of adjusting skin microecological balance, 25% of silicone oil, 10% of sorbitol, 4% of APG emulsifier, 10% of 16-18 alcohol, 1.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 20% of schizosaccharomyces cerevisiae fermentation product lysate, 1% of peppermint extract, 1% of peony hydrosol and the balance of deionized water, wherein the total amount is 100%; the composition capable of adjusting the microecological balance of the skin is prepared from the following components in parts by weight: 30 parts of white ginseng fungus extract, 10 parts of probiotic metabolite and 10 parts of pearl oyster meat antioxidant peptide.

3. The skin lotion is prepared from the following components in percentage by weight: composition capable of regulating skin microecological balance 5%, C12-20 alkyl glucoside 2%, 16-18 alcohol 1%, silk oil 3%, shea butter 2%, isononyl isononanoate 3%, Spanish nut oil 4%, silicone oil 2%, glycerin 5%, sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-600.8%, p-hydroxyacetophenone 0.5%, hexanediol 0.5%, schizosaccharomyces cerevisiae fermentation product lysate 5%, peony hydrosol 0.02%, and balance deionized water, totaling 100%; the composition capable of adjusting the microecological balance of the skin is prepared from the following components in parts by weight: 22 parts of white ginseng fungus extract, 6 parts of probiotic metabolite, 6 parts of pearl oyster meat antioxidant peptide and 2 parts of tocopherol acetate.

4. The skin lotion is prepared from the following components in percentage by weight: composition capable of regulating the microecological balance of skin 5%, C12-20 alkyl glucoside 2%, 16-18 alcohol 1%, tocopherol acetate 3%, shea butter 2%, isononyl isononanoate 3%, Spanish nut oil 4%, silicone oil 2%, propylene glycol 5%, sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-600.8%, p-hydroxyacetophenone 0.5%, hexanediol 0.5%, yeast bifidus fermentation product lysate 3%, peony hydrosol 0.02%, and the balance of deionized water, totaling 100%; the composition capable of adjusting the microecological balance of the skin is prepared from the following components in parts by weight: 28 parts of white ginseng fungus extract, 10 parts of probiotic metabolite, 10 parts of pearl oyster meat antioxidant peptide and 5 parts of tocopherol acetate.

5. The skin lotion is prepared from the following components in percentage by weight: composition capable of regulating the microecological balance of the skin by 5%, C12-20 alkyl glucoside 2%, 16-18 alcohol 2%, silk oil 3%, shea butter 2%, isononyl isononanoate 3%, Spanish nut oil 2%, silicone oil 2%, glycerin 5%, sodium acrylate/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate-800.8%, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 0.3%, p-hydroxyacetophenone 0.5%, hexanediol 0.5%, yeast dileakage fermentation product lysate 5%, peony hydrosol 0.02%, and the balance of deionized water, the total being 100%; the composition capable of adjusting the microecological balance of the skin is prepared from the following components in parts by weight: 25 parts of white ginseng fungus extract, 8 parts of probiotic metabolite, 8 parts of pearl oyster meat antioxidant peptide and 3 parts of tocopherol acetate.