CN117323271B - Acne-removing composition, and preparation method and application thereof - Google Patents
Acne-removing composition, and preparation method and application thereof Download PDFInfo
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- CN117323271B CN117323271B CN202311633573.3A CN202311633573A CN117323271B CN 117323271 B CN117323271 B CN 117323271B CN 202311633573 A CN202311633573 A CN 202311633573A CN 117323271 B CN117323271 B CN 117323271B
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- acne
- celery seed
- amino acid
- removing composition
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Abstract
The invention discloses an acne-removing composition, a preparation method and application thereof, and belongs to the technical field of cosmetics, wherein the acne-removing composition comprises the following components in parts by mass: 1-4 parts of an amino acid surfactant, 1.5-3 parts of celery seed extract and 0.5-2 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate; the amino acid surfactant comprises the following components in parts by mass: 58-64 parts of hydrogenated starch hydrolysate, 23-27 parts of taurine, 4-8 parts of lysine hydrochloride, 1-5 parts of threonine and 4-8 parts of water. The composition provided by the invention has low temperature and low stimulation, can effectively inhibit sebum secretion, inhibit lipase activity, effectively inhibit acne bacillus, improve skin microecology, avoid excessive keratinization of a pilosebaceous duct, eliminate follicular angular embolism, and reduce and inhibit acne formation.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, and a preparation method and application thereof.
Background
Acne is one of the most common skin problems, commonly known as "acne", a chronic inflammatory skin disease affecting sebaceous glands, and is mainly manifested by acne, pimples, pustules, nodules, cysts and the like. The acne is well developed in adolescent population, is closely related to vigorous sebum secretion of teenagers and oily skin, and in addition, the androgen induces abnormal secretion of sebaceous glands, abnormal keratosis of hair follicle sebaceous ducts, proliferation of propionibacterium acnes, immune inflammatory reaction and other factors are closely related to the occurrence of acne.
The common active substances for acne removal include retinoic acid, benzoyl peroxide, antibiotics, salicylic acid, prednisone and dexamethasone. However, salicylic acid, prednisone and dexamethasone have strong side effects and high cost, and retinoic acid can increase the photosensitivity of skin and cause the skin to reddish; benzoyl peroxide has certain irritation, and individual patients can have reactions such as redness, desquamation and the like; antibiotics can cause bacterial drug resistance, and the using course of the antibiotics cannot be too long.
CN115501124a discloses a scalp care composition, a preparation method thereof and a scalp care agent, wherein each 100 parts of the scalp care composition comprises 1-5 parts of a multi-amino acid conditioner and 1-46 parts of a moisturizing and soothing component; wherein, according to the mass percent of the multi-element amino acid conditioner, the multi-element amino acid conditioner comprises 4-8wt% of water, 58-7wt% of hydrogenated starch hydrolysate, 23-27wt% of taurine, 4-8wt% of lysine hydrochloride and 1-5wt% of threonine, and the multi-element amino acid conditioner further can bring soft and smooth feeling to hair, can not accumulate after long-term use, has excellent skin-friendly property, has high moisturizing, quick absorption and excellent skin-feel experience, is very mild, can make scalp skin have luster and has high moisturizing effect, but does not disclose how the multi-element amino acid conditioner has an effect on acne removal.
CN116370512a discloses a celery seed extract, its preparation method and application in uric acid reduction, which comprises preparing curcumin into alkaline solution, preparing polyglycolic acid into acidic solution, mixing the two solutions to prepare modified alcohol, mixing choline chloride and the modified alcohol to obtain mixed liquid, adding 3-diethylaminophenol and urotropine injection into water, adding (S) -2-chloro-1- (2, 4-dichlorophenyl) ethanol and the mixed liquid, reacting at high temperature, washing, centrifuging, and freeze drying to obtain the extraction auxiliary agent. The celery seed extract is prepared by carrying out enzymolysis on celery seed powder by adopting enzyme, adding an extraction auxiliary agent to obtain filter residues and filtrate, carrying out reflux extraction on the filter residues by adopting ethyl acetate, extracting by adopting an ethanol water solution under an alkaline environment, eluting the filtrate by adopting macroporous resin and the ethanol water solution, concentrating and drying, and does not disclose what effect the prepared celery seed extract has in acne removal.
In view of this, the present application is presented.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an acne removing composition, a preparation method and application thereof, wherein the composition has an excellent acne removing effect.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
an acne removing composition comprises the following components in parts by mass: 1-4 parts of an amino acid surfactant, 1.5-3 parts of celery seed extract and 0.5-2 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate;
the amino acid surfactant comprises the following components in parts by mass: 58-64 parts of hydrogenated starch hydrolysate, 23-27 parts of taurine, 4-8 parts of lysine hydrochloride, 1-5 parts of threonine and 4-8 parts of water.
As a preferred embodiment of the present invention, the acne-removing composition comprises the following components in parts by mass: 2-3.5 parts of amino acid surfactant, 1.2-2.5 parts of celery seed extract and 1.3-1.5 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate.
As a preferred embodiment of the present invention, the preparation method of the celery seed extract comprises:
adding the celery seed powder and the compound enzyme into water, carrying out enzymolysis and filtering;
separating the filtrate with macroporous adsorbent resin, and drying to obtain celery seed extract;
the complex enzyme comprises pectase, beta-amylase and beta-glucanase.
As a preferred embodiment of the invention, the mass ratio of the celery seed powder to the pectase to the beta-amylase to the beta-glucanase to the water is 1: (0.01 to 0.03): (0.005-0.02): (0.005-0.02): (4-10).
As a preferred embodiment of the invention, the enzymolysis temperature is 45-55 ℃ and the enzymolysis time is 2-5 h.
As a preferred embodiment of the present invention, the filtrate is separated by passing through a macroporous adsorbent resin column, concretely:
and (3) regulating the pH of the filtrate to 5.8-6.5, passing through macroporous adsorption resin at a flow rate of 0.5-2 BV/h, washing with water at a flow rate of 1-2 BV/h, washing with 60-85 wt% ethanol solution at a flow rate of 1-2 BV, and collecting ethanol solution eluent.
As a preferred embodiment of the present invention, the macroporous adsorbent resin is a styrene type polar copolymer.
As a preferred embodiment of the present invention, the present invention further comprises the following components in parts by mass: 0.05-0.2 part of sodium hyaluronate, 0.1-0.3 part of chitosan, 0.1-0.4 part of thickener, 0.2-0.6 part of beta-glucan, 0.3-0.8 part of tocopheryl acetate, 0.4-1 part of betaine, 0.5-1 part of bisabolol, 2-5 parts of 1, 2-pentanediol, 4-10 parts of glycerin and 70-85 parts of water.
As a preferred embodiment of the present invention, the thickener comprises at least one of xanthan gum, hydrolyzed small nuclear fungus gum, hydroxyethyl cellulose, carrageenan, rose bean gum, guar gum, carboxymethyl cellulose, sodium polyacrylate, and acrylic acid (ester) cross-linked polymer.
The invention also provides a preparation method of the acne-removing composition, which comprises the following steps: adding sodium hyaluronate, thickener, chitosan amine, amino acid surfactant, 1, 2-pentanediol and glycerol into water, stirring, adding the rest materials, and stirring to obtain acne removing composition.
The invention also provides application of the acne-removing composition in preparation of cosmetics.
As a preferred embodiment of the present invention, the cosmetic is in the form of an aqueous solution, an emulsion, a cream, a gel, a mask or an essence.
The invention has the beneficial effects that: the composition disclosed by the invention has an excellent acne removing effect, is mild and low in stimulation, can effectively inhibit sebum secretion, inhibit lipase activity, effectively inhibit acne bacillus, improve skin microecology, avoid excessive keratinization of a pilosebaceous duct, eliminate hair follicle angular embolism, reduce and inhibit acne formation, simultaneously can relieve skin sensitivity, repair skin barriers, enhance skin tolerance, adjust skin secreted grease content, avoid skin accumulation pore blockage, effectively moisten and tighten skin, promote cell metabolism and prevent cell aging, repair damaged horny layer lipid barriers and increase skin resistance, and has a wide application prospect.
Detailed Description
For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
In the present application, the technical features described in an open manner include a closed technical scheme composed of the listed features, and also include an open technical scheme including the listed features.
In the present application, reference is made to numerical intervals, where the numerical intervals are considered to be continuous unless specifically stated, and include the minimum and maximum values of the range, and each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range description features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to include any and all subranges subsumed therein.
In the present application, the specific dispersing and stirring treatment method is not particularly limited.
The raw materials or instruments for the components used in each example and comparative example of the present invention were all commercially available raw materials or instruments unless otherwise specified, and the raw materials for the components used in each parallel experiment were all the same.
The embodiment of the application provides an acne-removing composition, which comprises the following components in parts by mass: 1-4 parts of an amino acid surfactant, 1.5-3 parts of celery seed extract and 0.5-2 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate;
the amino acid surfactant comprises the following components in parts by mass: 58-64 parts of hydrogenated starch hydrolysate, 23-27 parts of taurine, 4-8 parts of lysine hydrochloride, 1-5 parts of threonine and 4-8 parts of water.
The composition has the advantages of being mild and low in stimulation, capable of effectively inhibiting sebum secretion, inhibiting lipase activity, effectively inhibiting acne bacillus, improving skin microecology, avoiding excessive keratinization of a sebaceous gland duct, eliminating hair follicle angular embolism, reducing and inhibiting acne, simultaneously relieving skin sensitivity, repairing skin barriers, enhancing skin tolerance pores, adjusting skin secreted grease content, avoiding skin accumulation and blockage, effectively moistening and tightening skin, promoting cell metabolism and preventing cell aging, repairing damaged stratum corneum lipid barriers, and increasing skin resistance.
The amino acid surfactant has the advantages of mild and low stimulation, can effectively purify skin, inhibit sebum secretion, inhibit lipase activity, has excellent oil control effect, can effectively inhibit acne bacillus, improve microecology of skin, has good compatibility in a formula system, can promote balanced adsorption of grease, improves adsorption rate, can form liquid crystal phase through skin horny layer, prevents the horny layer from being converted into solid crystal phase, avoids excessive keratinization of a hair follicle sebaceous duct, eliminates hair follicle angular embolism, reduces and inhibits formation of acne, and further realizes excellent acne removing effect.
In the present invention, the preparation method of the amino acid surfactant is not limited, and the amino acid surfactant can be prepared by uniformly mixing the raw materials.
Wherein the representative amino acid surfactant is BAFEORII ® ULA 25 P0, which comprises the following components in parts by mass: 60 parts of hydrogenated starch hydrolysate, 25 parts of taurine, 6.5 parts of lysine hydrochloride, 2.5 parts of threonine and 6 parts of water.
The Leuconostoc mesenteroides/radix Raphani (RAPCANUS SATIVUS) root fermentation product filtrate has excellent anti-sensitization, anti-inflammatory and antibacterial effects, can effectively quench acne bacillus, inhibit other bacteria and fungi, balance skin microecology, quickly eliminate acnes, relieve skin sensitization degree, repair skin barrier, enhance skin tolerance, adjust the grease content secreted by skin, avoid skin accumulation pore blockage, and effectively moisten and tighten skin.
Among them, a representative Leuconostoc/radish (RAHANUS SATIVUS) root fermentation product filtrate is Synsil (Cynoguard ™ PF 1) in U.S. .
The celery seed extract has excellent functions of astringing and refining pores, has excellent antioxidant and anti-inflammatory effects, can promote cell metabolism, prevent cell aging, repair damaged stratum corneum lipid barrier and increase skin resistance, has excellent antibacterial effects, and can effectively inhibit acne bacillus.
The inventor of the invention discovers that when the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate are combined in parts by mass, the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate have a synergistic effect in the acne removal aspect, and all components interact and promote each other, so that an excellent acne removal effect is achieved.
The inventor researches the consumption of each raw material, if the consumption of the raw materials is too small or the total consumption of the raw materials is too small, the synergistic effect is not obvious, and if the consumption of the raw materials is too large or the total consumption of the raw materials is too large, antagonism can be generated, and further the acne removing effect can be reduced, so that the raw materials have ideal synergistic effect when the raw materials are in the scope of the invention.
In one embodiment, the acne-removing composition comprises the following components in parts by mass: 2-3.5 parts of amino acid surfactant, 1.2-2.5 parts of celery seed extract and 1.3-1.5 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate. Particularly, when the dosage of the raw materials is within the range, the synergistic effect is better and obvious, and the acne removing effect is better.
In one embodiment, the preparation method of the celery seed extract comprises the following steps:
adding the celery seed powder and the compound enzyme into water, carrying out enzymolysis and filtering;
separating the filtrate with macroporous adsorbent resin, and drying to obtain celery seed extract;
the complex enzyme comprises pectase, beta-amylase and beta-glucanase.
According to the invention, through enzymolysis of celery seed powder and then macroporous adsorption resin treatment, components with acne removal, oil control and oxidation resistance in celery seeds can be fully extracted, and the celery seed extract has excellent functions of astringing and refining pores, has excellent oxidation resistance and inflammation resistance, can promote cell metabolism and prevent cell aging, repair damaged horny layer lipid barrier and increase skin resistance, and simultaneously has excellent antibacterial effect, and can effectively inhibit acne bacillus.
The inventor of the invention researches and discovers that celery seed extracts obtained by different enzyme extraction show different effects, and the invention adopts pectinase, beta-amylase and beta-glucanase to combine endo enzyme and exo enzyme, so that celery seeds can be fully extracted, further celery seed extracts with excellent acne removing effect can be obtained, and other enzymes are adopted, so that the acne removing effect is reduced.
In one embodiment, the particle size of the celery seed powder is 100-400 meshes, and the celery seed powder is obtained by pulverizing celery seeds.
In one embodiment, the mass ratio of the celery seed powder to the pectase to the beta-amylase to the beta-glucanase to the water is 1: (0.01 to 0.03): (0.005-0.02): (0.005-0.02): (4-10).
In one embodiment, the enzymolysis temperature is 45-55 ℃ and the enzymolysis time is 2-5 h.
In one embodiment, the filtrate is separated by a macroporous adsorption resin column, specifically:
and (3) regulating the pH of the filtrate to 5.8-6.5, passing through macroporous adsorption resin at a flow rate of 0.5-2 BV/h, washing with water at a flow rate of 1-2 BV/h, washing with 60-85 wt% ethanol solution at a flow rate of 1-2 BV, and collecting ethanol solution eluent.
In one embodiment, the macroporous adsorbent resin is a styrene-type polar interpolymer.
In one embodiment, the representative styrene type polar copolymer is AB-8 macroporous adsorbent resin, S-8 macroporous adsorbent resin, and preferably S-8 macroporous adsorbent resin.
In one embodiment, the preparation method of the celery seed extract comprises the following steps:
crushing celery seeds to obtain celery seed powder;
adding the celery seed powder and the compound enzyme into water, carrying out enzymolysis and filtering;
and (3) regulating the pH of the filtrate to 5.8-6.5, passing through macroporous adsorption resin at a flow rate of 0.5-2 BV/h, washing with water at a flow rate of 1-2 BV/h, washing with 60-85 wt% ethanol solution at a flow rate of 1-2 BV, collecting ethanol solution eluent, and drying to obtain the celery seed extract.
When the macroporous resin is adsorbed, the resin column is a resin column conventional in the field, and the diameter-to-height ratio of the resin column is 1: 7-9.
In one embodiment, the composition further comprises the following components in parts by mass: 0.05-0.2 part of sodium hyaluronate, 0.1-0.3 part of chitosan, 0.1-0.4 part of thickener, 0.2-0.6 part of beta-glucan, 0.3-0.8 part of tocopheryl acetate, 0.4-1 part of betaine, 0.5-1 part of bisabolol, 2-5 parts of 1, 2-pentanediol, 4-10 parts of glycerin and 70-85 parts of water.
The sodium hyaluronate HAs certain anti-inflammatory and antioxidant effects, and HA can promote the repair of damaged skin by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen free radicals, and the source of the sodium hyaluronate is not limited, and Hua Xifu Ruida low molecular weight sodium hyaluronate (10 kDa-1 MDa) is preferably adopted.
The betaine is a natural moisture absorption factor, is a vitamin with a bioactive form, is very important for protein formation, DNA repair and enzyme activity, has excellent osmotic pressure regulation effect and stability, has strong moisture absorption, can provide a large amount of moisture for skin, and enables the skin to be smooth and moist all the time.
The chitosan amine has excellent transdermal absorbability, can improve the hydration of skin, promote the synthesis and secretion of hyaluronic acid by skin keratinocytes and fibroblasts, and can also be combined with lectin-like glycoprotein on keratin to interfere the combination and adhesion of the keratinocytes, thereby promoting the normal exfoliation of aged horny layer, promoting the metabolism of skin, achieving the effect of refining pores, simultaneously reducing local pigmentation, lightening skin color spots, relieving the phenomena of darkening skin color and uneven skin color caused by ultraviolet rays, and effectively homogenizing skin color.
The special structure can better hold the absorbed water and achieve the effect of water locking.
The tocopheryl acetate is a vitamin E derivative, has excellent antioxidant and anti-aging effects, has good moisturizing and anti-aging effects on skin, and can soften the touch of the skin and keep the moisture of the skin.
Wherein, the bisabolol has the functions of anti-inflammatory, antibacterial, soothing and calming skin, and meanwhile, the bisabolol also has a certain bactericidal function, so that the skin can be effectively protected from daily tension, and the healing process of the skin is accelerated.
Wherein, the 1, 2-pentanediol and the glycerol have excellent moisturizing effect and film forming effect, and the 1, 2-pentanediol and the glycerol have better permeation promoting effect.
In one embodiment, the thickener comprises at least one of xanthan gum, hydrolyzed small-core gum, hydroxyethyl cellulose, carrageenan, rose bean gum, guar gum, carboxymethyl cellulose, sodium polyacrylate, and acrylic acid (ester) cross-linked polymer.
The invention also provides a preparation method of the acne-removing composition, which comprises the following steps: adding sodium hyaluronate, thickener, chitosan amine, amino acid surfactant, 1, 2-pentanediol and glycerol into water, stirring, adding the rest materials, and stirring to obtain acne removing composition.
The invention also provides application of the acne-removing composition in preparation of cosmetics.
In one embodiment, the cosmetic is in the form of an aqueous solution, an emulsion, a cream, a gel, a mask or an essence.
In one embodiment, the acne-removing composition comprises 0.1-10% by mass of the cosmetic.
In one embodiment, the cosmetic further comprises an adjuvant acceptable in the cosmetic field.
In one embodiment, the cosmetically acceptable adjuvants include, but are not limited to, at least one of moisturizers, emollients, emulsifiers, preservatives, antioxidants, pH modifiers, penetration enhancers, liposomes, chelators, surfactants, fragrances, pigments.
In one embodiment, suitable humectants include, but are not limited to, at least one of propylene glycol, hexylene glycol, dipropylene glycol, polyethylene glycol, xylitol, diglycerol, maltose, D-mannitol, dipropylene glycol, polypropylene glycol, erythritol, sorbitol, mannitol, xylitol, glucose, lactose, mannose, maltose, inositol, sorbitol, sorbitan, trehalose, starch hydrolyzing sugars.
In one embodiment, suitable emollients include, but are not limited to, at least one of squalane, isododecane, isohexadecane, shea butter, polydimethylsiloxane, tetraisostearate, cyclopentadimethicone, diisostearyl malate, dicetyl stearyl dimer linoleate, caprylic/capric triglyceride, hexyl laurate, polyglycerol 2-diisostearate, hydrogenated polyisobutene, pentaerythritol, caprylic capric triglyceride, octyldodecanol, dioctyl carbonate, macadamia nut oil, jojoba oil, lanolin, white oil, almond oil, olive oil, jojoba oil, castor oil, isononyl isononanoate, dioctyl adipate, octyl stearate, hexyl laurate, cocoa caprylate, caprate.
In one embodiment, suitable emulsifiers include, but are not limited to, at least one of PEG-30 soy sterol, polyglycerol-10 stearate, polyglycerol-10 laurate, polyglycerol-10 myristate, polyglycerol-5 trioleate, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PPG-13-decyl tetradecyl polyether-24, nonylphenol polyether-12, sclero-polyether-2, sclero-polyether-21, hydrogenated lecithin.
In one embodiment, suitable antioxidants include, but are not limited to, carotenoids, ascorbic acid, ascorbyl palmitate, magnesium ascorbyl phosphate, resveratrol, triethyl citrate, arbutin, superoxide dismutase, sodium metabisulfite, and combinations thereof.
In one embodiment, suitable pH adjusting agents include, but are not limited to, arginine, triethanolamine, citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, and combinations thereof.
In one embodiment, suitable colorants include, but are not limited to, white, black, yellow, blue, green, pink, red, orange, violet, indigo, brown, and the like colors, and combinations thereof.
In one embodiment, suitable preservatives include, but are not limited to, butyl paraben, diazolidinyl urea, ethyl paraben, isobutyl paraben, methyl paraben, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, and combinations thereof.
The following examples are provided to facilitate an understanding of the present invention. These examples are not provided to limit the scope of the claims.
Example 1
An acne removing composition comprises the following components in parts by mass: 3 parts of amino acid surfactant, 1.6 parts of celery seed extract, 1.4 parts of leuconostoc/radish root fermentation product filtrate (Cytoguard ™ PF1, the same applies hereinafter), 0.1 part of sodium hyaluronate, 0.2 part of chitosan, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerin, and 82.3 parts of water.
The amino acid surfactant comprises the following components in parts by mass: 60 parts of hydrogenated starch hydrolysate, 25 parts of taurine, 6.5 parts of lysine hydrochloride, 2.5 parts of threonine and 6 parts of water.
The preparation method of the celery seed extract comprises the following steps:
pulverizing celery seeds to 200 meshes to obtain celery seed powder;
adding celery seed powder, pectase, beta-amylase and beta-glucanase into water, performing enzymolysis for 2 hours at 50 ℃, and filtering; the mass ratio of the celery seed powder to the pectase to the beta-amylase to the beta-glucanase to the water is 1:0.02:0.01:0.01:8, 8;
and regulating the pH of the filtrate to 6.2, passing through S-8 macroporous adsorption resin at a flow rate of 1BV/h, eluting at a speed of 1.5BV/h, washing with water of 1.5BV, washing with 80wt% ethanol solution of 1.5BV, collecting ethanol solution eluent, and drying to obtain the celery seed extract.
The preparation method of the acne-removing composition comprises the following steps: adding sodium hyaluronate, hydrolyzed sclerotium rolfsii, chitosan, amino acid surfactant, 1, 2-pentanediol, glycerol and water, stirring, adding the rest materials, and stirring to obtain acne removing composition.
Example 2
Example 2 differs from example 1 in that the amount of the amino acid surfactant, celery seed extract, and Leuconostoc/radish root fermentation product filtrate of example 2 used as raw materials was different from example 1, and the other were the same.
An acne removing composition comprises the following components in parts by mass: 4 parts of amino acid surfactant, 1.5 parts of celery seed extract, 0.5 part of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerin and 82.3 parts of water.
Example 3
Example 3 differs from example 1 in that the amount of the amino acid surfactant, celery seed extract, and Leuconostoc/radish root fermentation product filtrate of example 3 used as raw materials is different from example 1, and the other are the same.
An acne removing composition comprises the following components in parts by mass: 1 part of amino acid surfactant, 3 parts of celery seed extract, 2 parts of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 82.3 parts of water.
Example 4
Example 4 differs from example 1 in that the amount of the amino acid surfactant, celery seed extract, and Leuconostoc/radish root fermentation product filtrate of example 4 used as raw materials is different from example 1, and the other are the same.
An acne removing composition comprises the following components in parts by mass: 2 parts of amino acid surfactant, 2.5 parts of celery seed extract, 1.5 parts of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerin and 82.3 parts of water.
Example 5
Example 5 differs from example 1 in that the amount of the amino acid surfactant, celery seed extract, and Leuconostoc/radish root fermentation product filtrate of example 5 used as raw materials is different from example 1, and the other are the same.
An acne removing composition comprises the following components in parts by mass: 3.5 parts of amino acid surfactant, 1.2 parts of celery seed extract, 1.3 parts of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 82.3 parts of water.
Example 6
Example 6 differs from example 1 in that the preparation method of celery seed is different from example 1, all the other things being equal.
The preparation method of the celery seed extract comprises the following steps:
pulverizing celery seeds to 200 meshes to obtain celery seed powder;
adding celery seed powder, pectase, beta-amylase and beta-glucanase into water, performing enzymolysis for 2 hours at 50 ℃, and filtering; the mass ratio of the celery seed powder to the pectase to the beta-amylase to the beta-glucanase to the water is 1:0.02:0.01:0.01:8, 8;
and regulating the pH of the filtrate to 6.2, passing through AB-8 macroporous adsorption resin at a flow rate of 1BV/h, eluting at a flow rate of 1.5BV/h, washing with water of 1.5BV, washing with 80wt% ethanol solution of 1.5BV, collecting ethanol solution eluent, and drying to obtain the celery seed extract.
Example 7
Example 7 differs from example 1 in that the preparation method of celery seed is different from example 1, all the other things being equal.
The preparation method of the celery seed extract comprises the following steps:
pulverizing celery seeds to 200 meshes to obtain celery seed powder;
adding celery seed powder, pectase, beta-amylase and beta-glucanase into water, performing enzymolysis for 2 hours at 50 ℃, and filtering; the mass ratio of the celery seed powder to the pectase to the beta-amylase to the beta-glucanase to the water is 1:0.025:0.015:0.005:10;
and regulating the pH of the filtrate to 6.2, passing through AB-8 macroporous adsorption resin at a flow rate of 1BV/h, eluting at a flow rate of 1.5BV/h, washing with water of 1.5BV, washing with 80wt% ethanol solution of 1.5BV, collecting ethanol solution eluent, and drying to obtain the celery seed extract.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain an amino acid surfactant, and all other things are the same.
An acne removing composition comprises the following components in parts by mass: 1.6 parts of celery seed extract, 1.4 parts of leuconostoc/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium gum, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 85.3 parts of water.
Comparative example 2
Comparative example 2 is different from example 1 in that comparative example 2 does not contain celery seed extract, and all other things are the same.
An acne removing composition comprises the following components in parts by mass: 3 parts of amino acid surfactant, 1.4 parts of leuconostoc/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium gum, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 83.9 parts of water.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain Leuconostoc/radish root fermentation product filtrate, all other things being equal.
An acne removing composition comprises the following components in parts by mass: 3 parts of amino acid surfactant, 1.6 parts of celery seed extract, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 83.7 parts of water.
Comparative example 4
Comparative example 4 differs from example 1 in that comparative example 4 does not contain an amino acid surfactant (the total amount of amino acid surfactant, celery seed extract, leuconostoc/radish root fermentation product filtrate remains unchanged), all other things being equal.
An acne removing composition comprises the following components in parts by mass: 3.1 parts of celery seed extract, 2.9 parts of leuconostoc/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium gum, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 82.3 parts of water.
Comparative example 5
Comparative example 5 differs from example 1 in that comparative example 5 does not contain celery seed extract (amino acid surfactant, celery seed extract, leuconostoc mesenteroides/radish root fermentation product filtrate total amount remains unchanged), all other things being equal.
An acne removing composition comprises the following components in parts by mass: 3.8 parts of amino acid surfactant, 2.2 parts of leuconostoc/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium gum, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 82.3 parts of water.
Comparative example 6
Comparative example 6 differs from example 1 in that comparative example 6 does not contain Leuconostoc/radix Raphani fermentation product filtrate (amino acid surfactant, celery seed extract, leuconostoc/radix Raphani fermentation product filtrate total amount remains unchanged), all other things being equal.
An acne removing composition comprises the following components in parts by mass: 3.7 parts of amino acid surfactant, 2.3 parts of celery seed extract, 0.1 part of sodium hyaluronate, 0.2 part of chitosan, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 82.3 parts of water.
Comparative example 7
Comparative example 7 differs from example 1 in that the amino acid surfactant, celery seed extract, leuconostoc mesenteroides/radish root fermentation product filtrate amount of comparative example 7 is different from example 1, and the other are the same.
An acne removing composition comprises the following components in parts by mass: 5 parts of amino acid surfactant, 0.7 part of celery seed extract, 0.3 part of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerin and 82.3 parts of water.
Comparative example 8
Comparative example 8 differs from example 1 in that the amino acid surfactant, celery seed extract, leuconostoc mesenteroides/radish root fermentation product filtrate amount of comparative example 8 is different from example 1, and the other are the same.
An acne removing composition comprises the following components in parts by mass: 0.5 part of amino acid surfactant, 1.2 parts of celery seed extract, 4.3 parts of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.1 part of sodium hyaluronate, 0.2 part of chitosan amine, 0.2 part of hydrolyzed sclerotium rolfsii, 0.3 part of beta-glucan, 0.5 part of tocopheryl acetate, 0.6 part of betaine, 0.8 part of bisabolol, 3 parts of 1, 2-pentanediol, 6 parts of glycerol and 82.3 parts of water.
Comparative example 9
Comparative example 9 is different from example 1 in that the preparation method of the celery seed extract of comparative example 9 is different from example 1, and the other are the same.
The preparation method of the celery seed extract comprises the following steps:
pulverizing celery seeds to 200 meshes to obtain celery seed powder;
adding semen Apii powder, pectase, flavourzyme and alkaline protease into water, performing enzymolysis at 50deg.C for 2 hr, and filtering; the mass ratio of the celery seed powder to the pectase to the flavourzyme to the alkaline protease to the water is 1:0.02:0.01:0.01:8, 8;
and regulating the pH of the filtrate to 6.2, passing through S-8 macroporous adsorption resin at a flow rate of 1BV/h, eluting at a speed of 1.5BV/h, washing with water of 1.5BV, washing with 80wt% ethanol solution of 1.5BV, collecting ethanol solution eluent, and drying to obtain the celery seed extract.
Test case
Test example 1
5 alpha-reductase (5 alpha-reduction) inhibition test: 5α -reductase (5α -reductase) is a membrane protease dependent on reduced coenzyme ii (NADPH), an important androgen metabolizing enzyme in skin, capable of irreversibly converting Testosterone (Testosterone, T) into Dihydrotestosterone (DHT), DHT is the most active androgen, capable of inducing excessive secretion of grease from sebaceous glands, and reducing DHT levels by inhibiting 5α -reductase activity is effective in alleviating excessive secretion of grease from sebaceous glands, and the test results are shown in table 1.
1. The main reagent comprises: 5α -reductase (university of Guangdong medical science), finasteride (microphone), testosterone (Beijing Walker), reduced coenzyme II tetrasodium salt (NADPH, microphone).
2. The main equipment comprises: an enzyme-labeled instrument (BioTek, synergyLX), a water-proof constant temperature incubator (Shanghai-Heng, 9050), and a high-speed desk-top refrigerated centrifuge (Hunan Xiang instrument, H1850R).
3. The testing method comprises the following steps: 5 alpha-reductase inhibition assay
(1) Sample tube: adding 1mL of sample stock solution, 1mL of enzyme solution, 1mL of ADPH solution and 1mL of testosterone solution into a test tube, gently shaking, taking 200 mu L of 96-well ELISA plate by a pipette, placing each sample in three parallel, detecting by an ELISA meter, and measuring absorbance at 340nm to obtain a first measurement value A Sample 0 . After the sample is incubated for 20 minutes at 37 ℃, the sample is put into an enzyme-labeled instrument for detection, and the absorbance at 340nm is measured to be a second measurement value A Sample 20 。
(2) Enzyme tube: adding 1mLPBS solution, 1mL enzyme solution, 1mLNADPH solution and 1mL testosterone solution into a test tube, gently shaking, taking 200uL 96-well ELISA plate with a pipette, placing each sample in three parallel, detecting with an ELISA meter, and measuring absorbance at 340nm to obtain first measurement value A Enzyme 0 . After the sample is incubated for 20 minutes at 37 ℃, the sample is put into an enzyme-labeled instrument for detection, and the absorbance at 340nm is measured to be a second measurement value A Enzyme 20 The method comprises the steps of carrying out a first treatment on the surface of the Blank tests were also performed and the above test was repeated 3 times and averaged.
5α -reductase inhibition rate = 100% [1- (a) Sample 0 -A Sample 20 ）/（A Enzyme 0 -A Enzyme 20 ）。
Test example 2
Acne bacillus inhibition rate: the antibacterial performance of the examples and comparative examples of the present invention was measured by referring to GB15979-2002 "Disposable sanitary products Standard for sanitary products" appendix C4 "antibacterial performance test method for dissolution antibacterial products", and the test results are shown in Table 1.
(1) Preparation of bacterial suspension: washing Propionibacterium acnes 24h culture with 0.03mol/L phosphate buffer to obtain 10 5 CFU/mL bacterial suspension.
(2) 0.5g of test samples (samples of examples and comparative examples respectively) are respectively taken, 0.1mL of the bacterial suspension is added for uniform coating and mixing, timing is started, 9mL of 0.03mol/L phosphate buffer solution is added after 20min for full mixing, 3 dilutions are taken, 1mL of the solutions are respectively taken and placed in two parallel plates, and then the corresponding culture medium is added for culturing for 24 hours under anaerobic conditions at 36+/-1 ℃ for colony counting. The above test was repeated 3 times, averaged, and a blank control group was set.
Acnes inhibition = (a-B)/a×100%, a being the average recovered colonies of the control samples and B being the average recovered colonies of the test samples.
Test example 3
Human body experiment:
(1) 80 volunteers were selected and all volunteers were randomly divided into 16 groups of 5 persons each, each group of volunteers being tested with the compositions of examples and comparative examples, respectively.
Inclusion volunteer criteria were: the age of 20-30 years, the face has obvious acnes and pimples, and hormone medicines and immunosuppressants are not used in the last month; the test site is not currently available to other clinical trials within about 30 days; can be matched with a tester well; all contents of the informed consent form can be read and understood, and the informed consent form is voluntarily signed; during the test, it was agreed that no cosmetics, drugs and health products having an influence on the results were used.
Exclusion criteria: those with open wounds or erosive surfaces; highly allergic constitution; those with history of cosmetic allergy; female pregnant, lactating or intended to be pregnant during testing; has severe barycenter, liver and kidney function injury and severe hypoimmunity; patients with mental diseases and severe endocrine diseases and patients with oral contraceptives; clinical testers or other testers taking medicines within 30 days, or those who have medicines with systematic effects on test results within nearly 1 week; cosmetic products that may have an effect on the test results for oral and topical use within 2 weeks; researchers consider it unsuitable for participating in this test.
Abort and exit criteria: smearing the tested sample or performing a return visit record according to the requirement in the test period; during use, suffering from serious diseases or suffering from serious adverse reactions.
The testing method comprises the following steps: the volunteers used the above composition on the whole face for 14 days after cleansing the face daily in the morning and evening.
Skin oil contents of volunteers were measured on days 0 and 14 of the test samples, respectively, using a skin oil content tester Sebumeter manufactured by the company Courage+Khazaka (CK) of Germany, and the average value was taken three times each time, and the change rate of skin oil was calculated, and the measurement results are shown in Table 1.
Rate of change of skin oil= (D14-D10)/d0×100%, D14 is skin oil content on day 14, and D0 is skin oil content on day 0.
TABLE 1
As can be seen from table 1, the acne-removing composition of the present invention has excellent acne-removing effect.
As can be seen from comparative examples 1 to 7, example 1 is the best embodiment of the present invention, and has the best acne removing effect.
Comparative examples 1-5 show that by controlling the amounts of amino acid surfactant, celery seed extract, leuconostoc mesenteroides/radish root fermentation product filtrate: 2-3.5 parts of an amino acid surfactant, 1.2-2.5 parts of celery seed extract and 1.3-1.5 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate; further improving the acne removing effect.
As can be seen from comparative examples 1 and 1-6, the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate have remarkable synergistic effect in removing acnes, and the combination of the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate remarkably improves the acne removing effect, and if any one of the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate is absent, the effect is remarkably reduced.
As can be seen from comparative examples 1 and 7 to 8, the acne-removing effect is further improved by controlling the amounts of the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate within the range of the present invention, and if the amounts of the amino acid surfactant, the celery seed extract and the leuconostoc mesenteroides/radish root fermentation product filtrate deviate from the range of the present invention, the acne-removing effect of the present invention is significantly reduced, which means that the synergistic effect is more remarkable under the amounts defined by the present invention.
Comparative example 1 and comparative example 9 show that the celery seed extract prepared by the method can remarkably improve the acne removing effect.
Test example 4
Stability test: the examples and comparative examples were subjected to stability test, heat resistance test, which is to stand at 45 ℃ for one month, and appearance, color and smell thereof were observed; the cold resistance test is to stand for one month at the temperature of-18 ℃ and observe the appearance, color and smell; the thermal cycle performance test was carried out by storing at 45℃and normal temperature and-18℃for 24 hours, and circulating 3 times, and observing the appearance, color and smell. The test results are shown in Table 2.
TABLE 2
As can be seen from table 2, the acne-removing composition of the present invention has excellent stability.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made to the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (8)
1. The acne-removing composition is characterized by comprising the following components in parts by mass: 1-4 parts of amino acid surfactant, 1.5-3 parts of celery seed extract, 0.5-2 parts of leuconostoc mesenteroides/radish root fermentation product filtrate, 0.05-0.2 part of sodium hyaluronate, 0.1-0.3 part of chitosan, 0.1-0.4 part of thickener, 0.2-0.6 part of beta-glucan, 0.3-0.8 part of tocopheryl acetate, 0.4-1 part of betaine, 0.5-1 part of bisabolol, 2-5 parts of 1, 2-pentanediol, 4-10 parts of glycerin and 70-85 parts of water;
the amino acid surfactant comprises the following components in parts by mass: 58-64 parts of hydrogenated starch hydrolysate, 23-27 parts of taurine, 4-8 parts of lysine hydrochloride, 1-5 parts of threonine and 4-8 parts of water;
the preparation method of the celery seed extract comprises the following steps:
adding the celery seed powder and the compound enzyme into water, carrying out enzymolysis and filtering;
separating the filtrate with macroporous adsorbent resin, and drying to obtain celery seed extract;
the complex enzyme comprises pectase, beta-amylase and beta-glucanase;
separating the filtrate by a macroporous adsorption resin column, specifically:
adjusting the pH of the filtrate to 5.8-6.5, passing through macroporous adsorption resin at a flow rate of 0.5-2 BV/h, washing with water at a flow rate of 1-2 BV/h and washing with 60-85 wt% ethanol solution at a flow rate of 1-2 BV, and collecting ethanol solution eluent;
the macroporous adsorption resin is a styrene type polar copolymer.
2. The acne-removing composition according to claim 1, comprising the following components in parts by mass: 2-3.5 parts of amino acid surfactant, 1.2-2.5 parts of celery seed extract and 1.3-1.5 parts of Leuconostoc mesenteroides/radish root fermentation product filtrate.
3. The acne-removing composition according to claim 1, wherein the mass ratio of celery seed powder, pectase, beta-amylase, beta-glucanase and water is 1: (0.01 to 0.03): (0.005-0.02): (0.005-0.02): (4-10).
4. The acne-removing composition according to claim 1, wherein the enzymolysis temperature is 45-55 ℃ and the enzymolysis time is 2-5 h.
5. The acne-removing composition according to claim 1, wherein the thickener comprises at least one of xanthan gum, hydrolyzed sclerotium gum, hydroxyethyl cellulose, carrageenan, rose bean gum, guar gum, carboxymethyl cellulose, sodium polyacrylate, and cross-linked polymer of acrylic acid (ester).
6. The method for preparing the acne-removing composition according to any one of claims 1 to 5, which is characterized by comprising the following steps: adding sodium hyaluronate, thickener, chitosan amine, amino acid surfactant, 1, 2-pentanediol and glycerol into water, stirring, adding the rest materials, and stirring to obtain acne removing composition.
7. Use of the acne-removing composition according to any one of claims 1 to 5 in the preparation of cosmetics.
8. The use according to claim 7, wherein the cosmetic is in the form of an aqueous solution, an emulsion, a cream, a gel or a mask.
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